|Publication number||US3802430 A|
|Publication date||Apr 9, 1974|
|Filing date||Jun 30, 1972|
|Priority date||Jun 30, 1972|
|Publication number||US 3802430 A, US 3802430A, US-A-3802430, US3802430 A, US3802430A|
|Inventors||Arnold L, Schwebel P|
|Original Assignee||Arnold L, Schwebel P|
|Export Citation||BiBTeX, EndNote, RefMan|
|Patent Citations (7), Referenced by (155), Classifications (9)|
|External Links: USPTO, USPTO Assignment, Espacenet|
United States Patent [191. Schwebel et al.
1 DISPOSABLE PYROTECHNICALLY POWEREDINJECTOR  Inventors: Paul R. Schwebel, 13141 Oxnard St., Apt. 20, Van Nuys, Calif. 91401; Leonard G. Arnold, 17057 Adlon Rd., Encino, Calif. 91316  Filed: June 30, 1972  Appl. No.: 268,102
 US. Cl. 128/173 H  Int. Cl A61m 5/30  Field of Search ...128/173 H, 218 D, 218 F, 128/218 M, DIG. 11, DIG. 12,184, 215;
 References Cited UNITED STATES PATENTS 3,308,818 3/1967 Rutkowski 102/92 3,335,722 8/1967 Lowry et al 128/173 H 1 Apr.9,1974
2,322,245 Lockhart 128/173 n 2,322,244 6/1943 Lockhart 128/218 F 2,514,401 7/1950 Liljegren 102/8 2,575,071 11/1951 Rockwell 29/1 B 2,669,230 2/1954 Smoot 123/173 H Primary Examiner-Richard A. Gaudet Assistant Examiner-Henry .l. Recla Attorney, Agent, or Firm-Robert Louis Finkel 5 7] ABSTRACT A disposable pyrotechnically powered injector comprising a barrel formed to receive an ampule, an ampule having a plug at one end and an orifice at the other and containing a selected medicament, a plunger activated gas generating pyrotechnic charge, and a gas operated piston positioned in the barrel and adapted to drive the plug within the ampule and thereby discharge the medicament under high pressure through the orifice.
4 Claims, 5 Drawing Figures 17 42 I2 I I6 22 DISPOSABLE PYROTECHNICALLY POWERED INJECTOR SUMMARY OF THE INVENTION The subject invention relates generally to disposable needleless injectors and, more particularly, to a pyrotechnically powered hypodermic injector adapted to inject any desired medicament from a pre-packaged ampule through the skin in a fine, high pressure stream.
Copen 2,687,728; Morando 3,115,133; Lowry, et al.
3,335,722; and Clark 3,527,212. The advantages claimed for such devices are too well known to require reiteration. l 1
The prior art teaches the storage of a'propellant gas, such as CO under pressure in a cartridge or in a cavity formed in the injector body. The fluid medicament is usually stored in an ampule, which may be inserted into the'injector, or in a cavity in the injector itself. Various means are provided to puncture the pressure vessel and release the storedgas. The gas either acts on a piston or mixes with the medicament to drive the fluid through a small orifice which creates the injected high velocity stream. In one prior art device the propulsive gas is pre-mixed with the medicament. Lowry, et al. U.S. Pat. No. 3,335,722 utilizes conventional explosive cartridges to propel a specially designed plunger in a re'useable injector; however, as it points'out, direct explosive action has heretofore been considered unsuitable for hypodermic injectors.
The subject invention utilizes a single-shot preloaded pyrotechnic charge or deflagrant to propet a pistonactuated high velocity fluid injection system. The gasproducing deflagrant is activated by a primer, which in turn. is ignited by a firing pin having a manually released spring-operated trigger mechanism. A-frangible retaining member secures the firing pin in place to protect against accidental premature discharge.
The barrel of the injector is adapted to receive a prepackaged ampule containing the desired medicament. Theampule is provided with aninternal plug at the end received by the barrel of the injector and with one or more orifices in its other end.
When the triggering mechanism is activated the gas generated by the pyrotechnic charge drives a piston positioned in the mouth of the barrel against the plug,
forcing the latter into the ampule and discharging the medicament with sufficient velocity to pierce the skin. Means are provided within the barrel to prevent the propulsive gas from entering the ampule and contamihating the medicament, and to impede the release of this gas into the atmosphere. In a preferred embodiment of the invention, these results are achieved by mountingthe piston at the end of expansible bellows adapted to receive and contain the propulsive gas generated by the pyrotechnic charge.
From the foregoing brief summary it will be understood that-one of the principal objects of the subject invention is the provision of a needleless hypodermic injector of simple construction which may be easily and inexpensively produced so as to be economically disposable after use. Another object is the provision of a compact, lightweight and durable injector which may be conveniently packed for transportation and storage under the widest possible range of conditions. Still another object is the provision of a needleless hypodermic injector in which the propulsive force is furnished by gas generated by a pyrotechnic charge at the time of use, thereby eliminating the need for the more conventional specially constructed heavy-duty gas storage vessels of the prior art injectors.
The invention has for another object the inclusion in a gas operated hypodermic injector of means to preclude the possibility of contamination of the injected medicament by the propulsive gas and to avoid the possibility of injecting the gas itself under the skin. I
The design and construction of the actuating mechanism of the invention provide positive protection against both accidental discharge and misfiring.
Finally, the injector the subject invention is particularly well adapted to permit the standardization of packaging for substantially all known injectible medicaments.
Further objects and advantages will become apparent to the reader upon consideration of the followingdetailed description of several preferred embodiments of the subject invention as illustrated in the accompanying drawing in which:
DESCRIPTION OF THE DRAWING FIG. 1 is a side sectional view of a preferred embodiment of the subject invention prior to discharge;
FIG. 2 is a similar view of the embodiment illustrated in FIG. 1 at the time of discharge;
FIG. 3 is a front end view of the embodiment illustrated in FIG. 1;
FIG. 4 is a partially cut away side view of a modified form of the subject invention; and
FIG. 5 is a partially cut away view of another modified form of the invention.
Wherever practicable a single numeral is used for the same or functionally similar features in the several figures.
DETAILED DESCRIPTION Referring to the preferred embodiment depicted in FIGS. 1 and 2, the disposable needleless pyrotechnically powered hypodermic injector consists essentially of a cylindrical casing 11 having a hollow barrel 12 with an annular sleeve 13 at its end adapted to receive an ampule 14 containing a selected liquid medicament l5. Casing l1, ampule l4 and the various other components of the injector hereinafter described may be formed of any metal or plastic material having suitable strength, rigidity, resilience and chemical resistance. Cooperating means such as detents l6 and spiral grooves 17 may be provided to secure ampule 14 releasably to the end of barrel 12.
One end of ampule 14 is seated by means of a plug 18, and the other end is provided with passages 19 terminating in orifices 21. While a single discharge passage and orifice will suffice, it has been determined that a plurality of outlets covering a small area of skin are more effective and result in less pain and trauma to the patient. The optimum configuration is presently be lieved to be five passages having their orifices arranged as illustrated in FIG. 3. The end of ampule 14 is rounded outwardly and the central region 22 surround-- ing orifices 21 is recessed. A removeable protective cap 23 is sterilized and slipped over the end of ampule 14 to serve as a seal for passages 19 and a cover for the end of the ampule itself.
At the rear end of barrel 12 casing 11 is provided with an encapsulated pyrotechnic propellant charge 25, such as AM584 manufactured by the Bermite Division of Tasker Industries, having a uniform, progressive rate of burning over the required impulse period of l30250 milliseconds. A primer 26 is positioned to ignite pyrotechnic charge 25 when primer 26 is activated by firing pin 27 located in axial passage 28 within casing 11.
Firing pin 27 is mounted on the face of a disc 29 preferably of a frangible plastic having an annular rim 31 extending radially outwardly therefrom. The rim 31 of disc 29 is retained in an annular recess 32'formed in the inner wall of passage 28 by means of anend cap 32.
A plunger 36 is inserted into the bore of end cap 32 so that its shank 38 abuts the rear face of disc 29 and its head 39 extends outwardly of end cap 32. Resilient expansion means such as spring 41 exert in expansive force between head 39 of plunger 36 and the rear face of disc 29.
One end of expansive bellows 42 is sealed around the encapsulated pyrotechnic propellant 25 and adapted to receive all of the gases produced by charge 25 within its chamber 43. The opposite end of bellows 42 is sealed by piston 44. Piston 44 is adapted to butt against the rear face of plug 18 when ampule 14 is secured to the end of barrel 12.
In operation, with ampule 14 in place on barrel l2 protective cap 23 is removed and discarded and the tip of ampule 14 is pressed lightly against the skin 45 of the person to be injected.
Sufficient force is applied to head 39 of plunger 36 in the direction of disc 29 torupture annular rim 31 and thereby release disc 29. Under the combined influence of the manual force exerted on plunger 36 and the resilient force exerted by spring 41, firing pin 27 is thrust into primer 26, igniting the latter and thereby igniting pyrotechnic charge 25. The rapidly expanding gas generated by charge 25 quickly fills chamber 43 within bellows 42 and drives piston 44, and plug 18 before it, into ampule 14. Preferably the front face of plug 18 is shaped to conform with the front wall of the medicament containing chamber withinampule 14. Bellows 42 is adapted to permit piston 44 todrive plug 18 the full length of the chamber within ampule 14 and against the front wall of this chamber, thereby insuring that all of the medicament within this chamber is discharged through passages 19 and orifices 21 in a fine stream with a sufficiently high velocity to pierce the skin 45.
By selectively varying the quantity and strength of propellant charge 25, the expansive characteristics of bellows 42, the resiliency and frictional properties of piston 44 and plug 18, the dimensions of barrel l2 and ampule l4, and the number, size and design of passages 19 and orifices 21, the dosage, depth of penetration and various other injection perameters can readily be established at the time of manufacture.
The embodiment of the invention illustrated in FIG. 4 is substantially identical with that of FIG. 1, except that the former does not employ expansible bellows 42 to contain the gas produced by propellant charge 25.
Instead, an annular groove or manifold 51 is provided in the inner wall of barrel 12. Manifold 51 is ported to the atmosphere through a duct 52 terminating in a metering orifice 53 in the outer wall of casing 11. An 0- ring 54 is seated in an annular recess in the inner wall of the barrel 12 between manifold 51 and the end of barrel 12.
Piston 44 is of a length such that its rear end extends rearwardly of manifold 51 when it comes to rest after driving plug 18 the entire length of the chamber within ampule 14. In this configuration the O-ring prevents any of the propulsive gas generated by charge 25 from by-passing piston 44 and contaminating the medicament 15 within ampule 14, and manifold 51, duct 52 and metering orifice 53 insure that any gas trapped between piston 44 and the inner wall of barrel 12 will be discharged slowly into the atmosphere.
The embodiment of FIG. 5 is similar to that of FIG. 4, except that the former utilizes a packing gland 61 within a discharge port 62 in the wall of barrel 12 to bleed the propellant gas generated by charge 25 after it has imparted its thrust impulse to piston 44.
With each of the three embodiments, once the contents of ampule 14 have been discharged the entire injector is intended to be discarded.
With the foregoing in mind, what I claim as my invention is? 1. A disposable deflagratory powered injector comprising:
a hollow barrel having an expansible bellows chamber therein and an annular sleeve at one end adapted to receive an ampule;
an ampule slidably inserted into said sleeve, said ampule having a plug at one end and an orifice at the other end and containing a selected medicament;
an encapsulated gas-generating deflagratory charge positioned at the end of the barrel remote from said sleeve in direct and unobstructed communication with said bellows chamber and discharging all of the gas generated thereby under pressure into the adjacent end of said bellows;
a gas-operated piston carried by and forming a seal at the end of said bellows chamberremote from said charge, said piston engaging and driving the plug slidably within the ampule under the influence of the gas generated by said charge, and thereby discharging the medicament contained therein through the orifice under high pressure;
a primer effectively connected to the charge to ignite said charge when activated; and
a firing mechanism mounted in the end of the barrel containing said charge to activate said primer.
2. The deflagratory powered injector of claim 1 wherein said firing mechanism includes:
a firing pin positioned in the barrel adjacent the primer;
resilient means urging said firing pin against the primer with sufficient force to activate said primer;
releasable restraining means positioned between the barrel and the firing pin restraining said firing pin; and releasing means carried by the barrel and extending outwardly thereof for releasing said restraining means.
3. The deflagratory powered injector of claim 2 ture said frangible member. wherein: 4. The deflagratory powered injector of claim 3 said restraining means includes a recess in the inner wall of the barrel and a frangible member formed on said firing pin extending into said recess; and said releasing means includes a plunger mounted for P and the firing P axial movement in the barrel and adapted to rupwherein said resilient means is a spring carried by the 5 plunger and exerting expansive force between said
|Cited Patent||Filing date||Publication date||Applicant||Title|
|US2322244 *||Mar 18, 1940||Jun 22, 1943||Lockhart Marshall L||Hypodermic injector|
|US2322245 *||Apr 26, 1941||Jun 22, 1943||Marshall L Lockhart||Ypodermic injector and method of use thereof|
|US2514401 *||Aug 17, 1942||Jul 11, 1950||Us Sec War||Land mine|
|US2575071 *||Feb 27, 1948||Nov 13, 1951||Rockwell Gaynor O||Explosive-operated device|
|US2669230 *||Jul 30, 1947||Feb 16, 1954||Becton Dickinson Co||Injection apparatus|
|US3308818 *||Jul 24, 1964||Mar 14, 1967||Rutkowski Eugene V||Injection cartridge|
|US3335722 *||Nov 1, 1963||Aug 15, 1967||Olin Mathieson||Hypodermic device|
|Citing Patent||Filing date||Publication date||Applicant||Title|
|US4124024 *||Mar 3, 1977||Nov 7, 1978||Schwebel Paul R||Disposable hypodermic injection ampule|
|US5074843 *||Nov 3, 1989||Dec 24, 1991||Tino Dalto||Device for subcutaneous injection without a needle|
|US5312335 *||Jun 13, 1991||May 17, 1994||Bioject Inc.||Needleless hypodermic injection device|
|US5371015 *||Jan 9, 1991||Dec 6, 1994||Cornell Research Foundation, Inc.||Apparatus for transporting substances into living cells and tissues|
|US5478744 *||Aug 12, 1994||Dec 26, 1995||Cornell Research Foundation, Inc.||Method for transporting substances into living cells and tissues and apparatus therefor|
|US5480381 *||Aug 21, 1992||Jan 2, 1996||Weston Medical Limited||Needle-less injector|
|US5503627 *||May 9, 1994||Apr 2, 1996||Bioject, Inc.||Ampule for needleless injection|
|US5503628 *||Mar 15, 1995||Apr 2, 1996||Jettek, Inc.||Patient-fillable hypodermic jet injector|
|US5891086 *||Jul 27, 1994||Apr 6, 1999||Weston Medical Limited||Needle-less injector|
|US5993412 *||May 19, 1997||Nov 30, 1999||Bioject, Inc.||Injection apparatus|
|US6258062 *||Feb 25, 1999||Jul 10, 2001||Joseph M. Thielen||Enclosed container power supply for a needleless injector|
|US6270473||Mar 15, 1996||Aug 7, 2001||Jettek, Inc.||Hypodermic jet injector and disposable ampule|
|US6537245 *||Oct 6, 2000||Mar 25, 2003||Crossject Company||Needleless syringe with a friction activated pyrotechnic initiator|
|US6595956 *||Mar 23, 1999||Jul 22, 2003||Joseph Gross||Drug delivery device|
|US6610028 *||Jun 30, 2000||Aug 26, 2003||Crossject||Needless syringe provided with a piezoelectric triggering system|
|US6616627||Jan 5, 2001||Sep 9, 2003||Biovalve Technologies, Inc.||Injection device|
|US6666843||Oct 23, 2000||Dec 23, 2003||Crossject||Needleless syringe with temporarily retained thrusting means|
|US6689092 *||Mar 2, 2001||Feb 10, 2004||Boehringer International Gmbh||Needle-less injector of miniature type|
|US6758829||Mar 27, 2001||Jul 6, 2004||Crossject||Needleless syringe functioning with a double-composition pyrotechnic charge|
|US6932789||Jul 14, 2003||Aug 23, 2005||Boehringer Ingelheim International Gmbh||Needle-less injector of miniature type|
|US6942645 *||Feb 23, 2001||Sep 13, 2005||Crossject||Needleless syringe with two injection speed levels|
|US6951070||May 23, 2001||Oct 4, 2005||Piexon Ag||Defense device, preferably self-defense device and storage unit used therein|
|US6960184||Jun 18, 2002||Nov 1, 2005||Biovalve Technologies, Inc.||Injection devices|
|US6986754 *||Mar 19, 2002||Jan 17, 2006||Roche Diagnostics Gmbh||Needleless hypodermic injection system, application device and medication cartridge therefor|
|US7150409||Nov 30, 2001||Dec 19, 2006||Biovalve Technologies, Inc.||Injection systems|
|US7261702 *||Jun 30, 2000||Aug 28, 2007||Crossject||Needleless syringe operating with an impact wave generator through a wall|
|US7316090||Aug 23, 2005||Jan 8, 2008||Piexon Ag||Defense device, preferably self-defense device and storage unit used therein|
|US7320677||Oct 19, 2001||Jan 22, 2008||Société de Commercialisation des Produits de la Recherche Appliquée - Socpra Sciences et Génie, S.E.C.||Needleless syringe for the delivery of therapeutic agents|
|US7357780||May 24, 2004||Apr 15, 2008||Crossject||Needleless syringe functioning with a double-composition pyrotechnic charge|
|US7384413||Jun 13, 2003||Jun 10, 2008||Elan Pharma International Limited||Drug delivery device|
|US7455655 *||Mar 18, 2004||Nov 25, 2008||Crossject||Needleless injection device comprising means for regulating the gas pressure level in the combustion chamber|
|US7500960 *||Mar 18, 2004||Mar 10, 2009||Crossject||Needleless injection device comprising a pyrotechnic cartridge, and method of assembling such a device|
|US7513885 *||May 20, 2004||Apr 7, 2009||Crossject||Needleless syringe with membrane isolating a multiple duct injector|
|US7717874||May 28, 2004||May 18, 2010||Bioject, Inc.||Needle-free injection system|
|US7736344||Nov 22, 2006||Jun 15, 2010||Medtronic Minimed, Inc.||Infusion medium delivery device and method with drive device for driving plunger in reservoir|
|US7740607||Feb 22, 2005||Jun 22, 2010||Valeritas, Inc.||Modular units for use in an injection device|
|US7744589||Jun 7, 2007||Jun 29, 2010||Medtronic Minimed, Inc.||Infusion medium delivery device and method with drive device for driving plunger in reservoir|
|US7806867||Sep 8, 2003||Oct 5, 2010||Valeritas, Inc.||Injection device|
|US7814871||Oct 14, 2002||Oct 19, 2010||Team Holdings Limited||Self-priming portable device|
|US7854720||Nov 23, 2009||Dec 21, 2010||Bioject, Inc.||Needle-free injection system|
|US7905868||Oct 27, 2006||Mar 15, 2011||Medtronic Minimed, Inc.||Infusion medium delivery device and method with drive device for driving plunger in reservoir|
|US7931614 *||Nov 30, 2001||Apr 26, 2011||Valeritas, Inc.||Injection systems|
|US7958662||Nov 17, 2008||Jun 14, 2011||O.F. Mossberg & Sons, Inc.||Conditional activation of a cartridge|
|US7959715||Apr 29, 2008||Jun 14, 2011||Medtronic Minimed, Inc.||Systems and methods allowing for reservoir air bubble management|
|US7963954||Apr 22, 2008||Jun 21, 2011||Medtronic Minimed, Inc.||Automated filling systems and methods|
|US7998117||May 15, 2008||Aug 16, 2011||Elan Pharma International Limited||Drug delivery device|
|US8025658||Mar 25, 2009||Sep 27, 2011||Medtronic Minimed, Inc.||Adhesive patch systems and methods|
|US8083716||Dec 26, 2007||Dec 27, 2011||Medtronic Minimed, Inc.||Systems and methods allowing for reservoir air bubble management|
|US8096076||Dec 8, 2010||Jan 17, 2012||Taser International, Inc.||Systems and methods for a covered deployment unit for electronic weaponry|
|US8171850||Nov 17, 2008||May 8, 2012||Taser International, Inc.||Conditional activation of a cartridge|
|US8172929||May 27, 2011||May 8, 2012||Medtronic Minimed, Inc.||Systems and methods allowing for reservoir air bubble management|
|US8277415 *||Nov 22, 2006||Oct 2, 2012||Medtronic Minimed, Inc.||Infusion medium delivery device and method with drive device for driving plunger in reservoir|
|US8323250||Feb 7, 2008||Dec 4, 2012||Medtronic Minimed, Inc.||Adhesive patch systems and methods|
|US8361027||Jul 15, 2011||Jan 29, 2013||Alkermes Pharma Ireland Limited||Drug delivery device|
|US8361028||Jul 15, 2011||Jan 29, 2013||Alkermes Pharma Ireland Limited||Drug delivery device|
|US8434528||Apr 29, 2008||May 7, 2013||Medtronic Minimed, Inc.||Systems and methods for reservoir filling|
|US8444607||Oct 8, 2008||May 21, 2013||Medtronic Minimed, Inc.||Infusion medium delivery device and method with drive device for driving plunger in reservoir|
|US8484876||Mar 8, 2011||Jul 16, 2013||O.F. Mossberg & Sons, Inc.||Firearms for launching electrified projectiles|
|US8500681||Mar 21, 2011||Aug 6, 2013||Valeritas, Inc.||Injection systems|
|US8512288||Sep 1, 2006||Aug 20, 2013||Medtronic Minimed, Inc.||Infusion medium delivery device and method with drive device for driving plunger in reservoir|
|US8529553||Jul 2, 2009||Sep 10, 2013||Medtronic Minimed, Inc.||Infusion medium delivery device and method with drive device for driving plunger in reservoir|
|US8591457||Aug 10, 2005||Nov 26, 2013||Alza Corporation||Method for making a needle-free jet injection drug delivery device|
|US8597243||Apr 8, 2008||Dec 3, 2013||Medtronic Minimed, Inc.||Systems and methods allowing for reservoir air bubble management|
|US8597270||Jun 17, 2011||Dec 3, 2013||Medtronic Minimed, Inc.||Automated filling systems and methods|
|US8613725||Apr 8, 2011||Dec 24, 2013||Medtronic Minimed, Inc.||Reservoir systems and methods|
|US8821442 *||Aug 17, 2009||Sep 2, 2014||Roche Diagnostics Operations, Inc.||Infusion system|
|US8998881||Aug 10, 2005||Apr 7, 2015||Alza Corporation||Method for delivering drugs to tissue under microjet propulsion|
|US9089641||Aug 7, 2013||Jul 28, 2015||Medtronic Minimed, Inc.||Automated filling systems and methods|
|US9132231||Sep 14, 2012||Sep 15, 2015||Alkermes Pharma Ireland Limited||Drug delivery device|
|US9199030||Aug 20, 2013||Dec 1, 2015||Medtronic Minimed, Inc.||Infusion medium delivery device and method with drive device for driving plunger in reservoir|
|US9205191||Aug 7, 2013||Dec 8, 2015||Medtronic Minimed, Inc.||Automated filling systems and methods|
|US9522225||Mar 25, 2009||Dec 20, 2016||Medtronic Minimed, Inc.||Adhesive patch systems and methods|
|US20020151842 *||Nov 30, 2001||Oct 17, 2002||Gonnelli Robert R.||Injection systems|
|US20020156418 *||Nov 30, 2001||Oct 24, 2002||Gonnelli Robert R.||Injection systems|
|US20020161329 *||Nov 30, 2001||Oct 31, 2002||Gonnelli Robert R.||Injection systems|
|US20020169412 *||Mar 19, 2002||Nov 14, 2002||Hans-Peter Haar||Needleless hypodermic injection system, application device and medication cartridge therefor|
|US20030014006 *||Feb 23, 2001||Jan 16, 2003||Patrick Alexandre||Needleless syringe with two injection speed levels|
|US20030149397 *||Nov 30, 2001||Aug 7, 2003||Gonnelli Robert R.||Injection systems|
|US20030236498 *||Jun 13, 2003||Dec 25, 2003||Joseph Gross||Device for measuring volume of drug|
|US20040015126 *||Jul 14, 2003||Jan 22, 2004||Bernd Zierenberg||Needle-less injector of miniature type|
|US20040020946 *||May 23, 2001||Feb 5, 2004||Raphael Fleischhauer||Defense device, preferably self-defense device and storage unit used therein|
|US20040024350 *||Oct 19, 2001||Feb 5, 2004||Martin Brouillette||Needleless syringe for the subcutaneous delivery of therapeutic agents|
|US20040162517 *||Nov 24, 2003||Aug 19, 2004||Otto Furst||Needleless hydpodermic injection device with non-electric ignition means|
|US20040215137 *||May 20, 2004||Oct 28, 2004||Crossject||Needleless syringe with membrane isolating a multiple duct injector|
|US20040220525 *||Sep 8, 2003||Nov 4, 2004||Willis John P||Injection device|
|US20040249339 *||Jun 18, 2002||Dec 9, 2004||Biovalve Technologies, Inc.||Injection devices|
|US20050000711 *||Oct 14, 2002||Jan 6, 2005||Hurlstone Christopher John||Self-priming portable device|
|US20050010167 *||May 24, 2004||Jan 13, 2005||Crossject||Needleless syringe functioning with a double-composition pyrotechnic charge|
|US20050081419 *||Oct 15, 2002||Apr 21, 2005||Raphael Fleischhauer||Hand-held firing device comprising several cartridges|
|US20050145647 *||Jan 21, 2003||Jul 7, 2005||Jochen Neutz||Self-defence module and use thereof|
|US20050154350 *||Feb 22, 2005||Jul 14, 2005||Biovalve Technologies, Inc.||Injection devices|
|US20050267403 *||May 28, 2004||Dec 1, 2005||Sergio Landau||Needle-free injection system|
|US20060010745 *||Aug 23, 2005||Jan 19, 2006||Raphael Fleischhauer||Defense device, preferably self-defense device and storage unit used theein|
|US20060089595 *||Mar 18, 2004||Apr 27, 2006||Crossject||Needleless injection device comprising means for regulating the gas pressure level in the combustion chamber|
|US20060116631 *||Jun 22, 2005||Jun 1, 2006||Jim Fukushima||Needleless injector|
|US20060247573 *||Mar 18, 2004||Nov 2, 2006||Crossject||Needleless injection device comprising a pyrotechnic cartridge|
|US20070006506 *||Jul 8, 2005||Jan 11, 2007||Mey-Chu Lan||Liquid filling bullet for physical protection|
|US20070052139 *||Aug 10, 2005||Mar 8, 2007||Gilbert Scott J||Method for making a needle-free jet injection drug delivery device|
|US20070055199 *||Aug 10, 2005||Mar 8, 2007||Gilbert Scott J||Drug delivery device for buccal and aural applications and other areas of the body difficult to access|
|US20070055200 *||Aug 10, 2005||Mar 8, 2007||Gilbert Scott J||Needle-free jet injection drug delivery device|
|US20070214993 *||Jan 31, 2006||Sep 20, 2007||Milan Cerovic||Systems and methods for deploying electrodes for electronic weaponry|
|US20080051711 *||Nov 22, 2006||Feb 28, 2008||Medtronic Minimed, Inc.||Infusion medium delivery device and method with drive device for driving plunger in reservoir|
|US20080051727 *||Sep 1, 2006||Feb 28, 2008||Medtronic Minimed, Inc.||Infusion medium delivery device and method with drive device for driving plunger in reservoir|
|US20080077081 *||Jun 7, 2007||Mar 27, 2008||Medtronic Minimed, Inc.||Infusion medium delivery device and method with drive device for driving plunger in reservoir|
|US20080097326 *||Oct 27, 2006||Apr 24, 2008||Medtronic Minimed, Inc.||Infusion medium delivery device and method with drive device for driving plunger in reservoir|
|US20080097381 *||Nov 22, 2006||Apr 24, 2008||Medtronic Minimed, Inc.||Infusion medium delivery device and method with drive device for driving plunger in reservoir|
|US20080214997 *||Mar 6, 2008||Sep 4, 2008||Crossject||Needleless syringe functioning with a double-composition pyrotechnic charge|
|US20080215005 *||May 15, 2008||Sep 4, 2008||Joseph Gross||Drug delivery device|
|US20080269680 *||Apr 29, 2008||Oct 30, 2008||Medtronic Minimed, Inc.||Systems and methods for reservoir filling|
|US20080269681 *||Dec 26, 2007||Oct 30, 2008||Medtronic Minimed, Inc.||Systems and methods allowing for reservoir air bubble management|
|US20080269687 *||Feb 7, 2008||Oct 30, 2008||Medtronic Minimed, Inc.||Adhesive Patch Systems and Methods|
|US20080269713 *||Apr 22, 2008||Oct 30, 2008||Medtronic Minimed, Inc.||Automated filling systems and methods|
|US20090036870 *||Oct 8, 2008||Feb 5, 2009||Medtronic Minimed, Inc.||Infusion medium delivery device and method with drive device for driving plunger in reservoir|
|US20090198191 *||Mar 25, 2009||Aug 6, 2009||Medtronic Minimed, Inc.||Adhesive patch systems and methods|
|US20090270811 *||Jul 2, 2009||Oct 29, 2009||Medtronic Minimed, Inc.||Infusion medium delivery device and method with drive device for driving plunger in reservoir|
|US20100069831 *||Nov 23, 2009||Mar 18, 2010||Bioject Inc.||Needle-free injection system|
|US20100211011 *||Aug 17, 2009||Aug 19, 2010||Hans-Peter Haar||Infusion system|
|US20110172634 *||Mar 21, 2011||Jul 14, 2011||Valeritas, Inc.||Injection systems|
|US20110203151 *||Mar 8, 2011||Aug 25, 2011||Mossberg Alan I||Firearms for launching electrified projectiles|
|US20110230834 *||May 27, 2011||Sep 22, 2011||Medtronic Minimed, Inc.||Systems and methods allowing for reservoir air bubble management|
|US20130237916 *||Mar 12, 2013||Sep 12, 2013||Unitract Syringe Pty Ltd||Fill-finish cartridges for sterile fluid pathway assemblies and drug delivery devices incorporating fill-finish cartridges|
|CN1911466B *||Aug 10, 2006||Jan 14, 2015||阿尔扎公司||Method for delivering drugs to tissue under microjet propulsion|
|CN101797411A *||Mar 18, 2010||Aug 11, 2010||傅雅芬||Air-pressure type needleless injector power head|
|CN101797411B||Mar 18, 2010||Dec 7, 2011||傅雅芬||一种气压式无针注射器动力头|
|CN102921073A *||Nov 2, 2012||Feb 13, 2013||江苏丞宇米特医疗科技有限公司||Syringe-needle-free rapid syringe for different medicinal liquids|
|DE10057931A1 *||Nov 22, 2000||Aug 29, 2002||Peter Lell||Surgical instrument uses gas pressure produced by combustion of an explosive substance to drive a needle, in particular, in the form of a trocar into a human or animal body|
|DE10057931B4 *||Nov 22, 2000||Nov 8, 2007||Lell, Peter, Dr.-Ing.||Pyrotechnisch betriebenes chirurgisches Instrument (Pyronadel)|
|DE19701494A1 *||Jan 17, 1997||Jul 23, 1998||Boehringer Mannheim Gmbh||Transdermales Injektionssystem|
|DE19820172A1 *||Apr 29, 1998||Jan 27, 2005||Wolfgang Wagner||Injection arrangement for inserting a diagnostic carrier or medicament beneath a patient's skin has a compressed gas source and a valve closure for controlling the release of the gas that is used to inject a substance|
|DE29507987U1 *||May 15, 1995||Sep 19, 1996||Ferton Holding||Ejektionsgerät zur Hochdruckejektion einer Flüssigkeit|
|EP0197625A1 *||Jan 23, 1986||Oct 15, 1986||Bioject, Inc.||Hypodermic injection apparatus|
|EP0367677A1 *||Nov 3, 1989||May 9, 1990||Tino Dalto||Device for subcutaneous needle-less injection|
|EP0409674A1 *||Jun 14, 1990||Jan 23, 1991||PASTEUR MERIEUX SERUMS ET VACCINS, Société Anonyme :||Injection device without needle for doses contained in cartridges and cartridges for use in such a device|
|EP0754068A1||Apr 6, 1995||Jan 22, 1997||Defarges Alain Moreau||Needleless jet injection device|
|EP1158263A1||May 26, 2000||Nov 28, 2001||Piexon AG||Container for a fluid which is dispersible in the free air and self defence device comprising such a container|
|EP1752174A1 *||Aug 9, 2006||Feb 14, 2007||Alza Corporation||Needle-free jet injection drug delivery device|
|WO1990004989A1 *||Nov 3, 1989||May 17, 1990||Tino Dalto||Sub-cutaneous injection device without a needle|
|WO1990015633A1 *||Jun 14, 1990||Dec 27, 1990||Pasteur Merieux Serums Et Vaccins||Method for perfecting an apparatus for giving injections without a needle, the dose for which is contained within a cartridge, and the cartridges used therein|
|WO1992008508A1 *||Nov 11, 1991||May 29, 1992||Sy-Quest International Limited||Needleless hypodermic jet injector device|
|WO1999044658A1 *||Mar 3, 1999||Sep 10, 1999||Tino Dalto||Device for hypodermic injection without needle of a medicine in liquid form|
|WO2000050107A1 *||Feb 15, 2000||Aug 31, 2000||Drasler William J||Enclosed container power supply for a needleless injector|
|WO2001005452A1 *||Jun 30, 2000||Jan 25, 2001||Snpe||Needleless syringe provided with a piezoelectric triggering system|
|WO2001032243A1 *||Oct 23, 2000||May 10, 2001||Crossject||Needleless syringe with temporarily retained thrusting means|
|WO2001051109A1 *||Jan 4, 2001||Jul 19, 2001||Biovalve Technologies, Inc.||Injection device|
|WO2001078810A1 *||Mar 27, 2001||Oct 25, 2001||Crossject||Needleless syringe functioning with a double-composition pyrotechnic charge|
|WO2001089612A1||May 21, 2001||Nov 29, 2001||Team Holdings (Uk) Limited||Portable device for delivering medicaments and the like|
|WO2001090674A1||May 23, 2001||Nov 29, 2001||Piexon Ag||Defense device, preferably self-defense device and storage unit used therein|
|WO2003033058A1 *||Oct 14, 2002||Apr 24, 2003||Team Holdings (Uk) Limited||Self-priming portable device|
|WO2004050136A2 *||Nov 26, 2003||Jun 17, 2004||F. Hoffmann-La Roche Ag||Needleless hypodermic injection device with non-electric ignition means|
|WO2004050136A3 *||Nov 26, 2003||Aug 5, 2004||Roche Diagnostics Gmbh||Needleless hypodermic injection device with non-electric ignition means|
|WO2005118033A3 *||May 20, 2005||May 18, 2006||Ryan R Beylund||Needle-free injection system|
|WO2007149514A2 *||Jun 19, 2007||Dec 27, 2007||Corium International, Inc.||Methods, devices, and kits for microjet drug delivery|
|WO2007149514A3 *||Jun 19, 2007||Mar 20, 2008||Corium Int Inc||Methods, devices, and kits for microjet drug delivery|
|WO2008006249A1 *||Jul 7, 2006||Jan 17, 2008||Sichuan Nanshan Power Actuated Fastening System Co., Ltd||A liquid injection unit|
|WO2017140974A1 *||Feb 13, 2017||Aug 24, 2017||Crossject||Needle-less injector device having a curved membrane|
|International Classification||A61M5/20, A61M5/30, A61M5/31, A61M5/303|
|Cooperative Classification||A61M2005/3104, A61M5/2046, A61M5/30|