|Publication number||US3805767 A|
|Publication date||Apr 23, 1974|
|Filing date||Feb 26, 1973|
|Priority date||Feb 26, 1973|
|Also published as||CA1046372A, CA1046372A1, DE2407652A1, DE2407652B2|
|Publication number||US 3805767 A, US 3805767A, US-A-3805767, US3805767 A, US3805767A|
|Original Assignee||Erb Rene|
|Export Citation||BiBTeX, EndNote, RefMan|
|Patent Citations (6), Referenced by (156), Classifications (8), Legal Events (3)|
|External Links: USPTO, USPTO Assignment, Espacenet|
United States Patent [191 Erb [1111 3,805,767 [451 Apr. 23, 1974 22 Filed:
[ METHOD AND APPARATUS FOR NON-SURGICAL, REVERSIBLE STERILIZATION OF FEMALES [76'1" liiviitdif Robert Allan Erb, PO. Box 86,
Valley Forge, Pa. 19481 4 Feb. 26, 1973  Appl. No.: 335,816
 U.S. Cl....' 128/1 R, 128/130, 128/303 R  Int. Cl A6lb 19/00  Field of Search 128/1 R, 2 R, 130, 303 R  References Cited UNITED STATES PATENTS 3.042.030 7/1962 Read ....'.1.2s/130x Cook et a1. 128/2 R Primary ExaminerDa1ton Truluck Attorney, Agent, or Firm-Edward J. Sites  ABSTRACT A method and apparatus is provided for non-surgical reversible sterilization of females. In the method of this invention an apparatus to which a removable tip is attached is inserted into the uterus. The tip is, aligned with the uterine end of the oviduct. A curable elastomeric composition is injected, through an aperture in the tip, into the oviduct in an amount sufficient to fill the portion of the oviduct adjacent to the uterus. The elastomeric composition is allowed to solidify and adhere to the above noted tip. The apparatus is then removed with the tip being ejected from the apparatus so as to remain adhered to the resulting oviduct block. The above procedure is repeated. for the opposite oviduct. The resulting oviduct blocks prevent the passage of ovum from the ovaries to the uterus and sperm from entering'the oviduct thereby preventing conception. The oviduct blocks if desired can be removed non-surgically by utilizing an apparatus whichgrips the tip portion of the oviduct block and extracts the entire oviduct block from the oviduct.
9 Claims, 5 Drawing Figures PATENTEDAPRB 1974 SHEET 1 [1F 2 METHOD AND APPARATUS FOR NON-SURGICAL, REVERSIBLE STERILIZATION OF FEMALES The invention described herein was reduced to practice in the course of work under a grant oraward from the Department of Health, Education and Welfare.
BACKGROUND OF THE INVENTION 1. Field of the Invention This invention is concerned with a method and apparatus for non-surgical, reversible sterilization of females.
2. Description of the Prior Art One of the more pressing problems which is encountered in the World today is that of over population. The problem of over population which has been a substantial problem for a considerable period of time in certain highly populated areas, such as Asia and the Indian Sub-Continent is now becoming a problem in less populated areas of the World such as Europe and the Americas. Over population results in such long range problems as pollution, famine and even war.
Birth control has been relied on as the principal means to control over-population. In the field of birth control the prevention of conception is considerably more acceptable for controlling population growth than abortion. However, the methods heretofore suggested for contraception have had certain inherent problems which limited the applicability and effectiveness,
The ideal contraception method should be 100 percent effective in preventing conception; should not rely on willpower; should not interfere with the satisfaction of sexual relationships, and should be low in cost taking into consideration the effective life of the contraceptive method. In addition the contraceptive method must not have any harmful psychological side effects. An extremely important feature of an ideal contraceptive method especially for family planning is that it be reversible so that it will be possible to have additional children if desired.
The most common methods of contraception which are currently employed on a mass scale each have certain inherent deficiencies which limit their usefulness. The use of such techniques and devices such as rhythm, withdrawal, condoms and diaphragms and vaginal foams all have been found to be highly unreliable. The more recently promoted methods such as intrauterine devices and use of contraceptive pills likewise have certain defects which limit their effectiveness. The intrauterine devices cannot be utilized by all females and there is some indication that they cause irritation and discomfort and are often rejected by females. The contraceptive pill cannot be utilized by many females due to incompatability with their normal hormone balance. Furthermore, the use of the pill has been found to increase the risks of certain carcigenic conditions.
There are currently two methods in wide use which are generally considered to be effective contraceptive methods. These are oviduct ligation for females and vasectomy for males In both these methods the ducts from the reproductive organs are severed and accordingly the contraceptive technique if properly performed and there is no natural regeneration are 100% effective. However, both methods have the defect that it is difficult, if not impossible, to reverse the procedure so as to restore the normal reproductive capacity.
It has been well established by gynecologists that a primary cause ofinfertility in females is blockage of the oviducts from the ovary to the uterus. The ovum when discharged from the ovaries is absorbed by the body and is prevented from coming in contact with the sperm and accordingly conception does occur. Females having this natural condition normally do not even realize it exists and do not suffer any adverse side effect besides being infertile. Having been made aware of this natural condition those skilled in the art have suggested artificial blocking of the oviduct to impart sterility.
It was reported by Corfman et al. in Obstetrices and Gynecology Vol. 27 No.6 pages 880-883 (June 1966) that various substances could be injected transcervically into the oviducts.
Hefnawi et al. Amr. J. Obst and Gynec, Vol. 99, No. 3 pages 421-427 (Oct. 1, 1967) reported attempts to block the oviducts by the injecting of medical grade elastomeric materials in the uncured state into the ovi ducts and allowing the material to solidify in the oviducts. The elastomeric material was thinned prior to injection so as to have a relatively fluid mixture for injection. The reported results obtained with rabbits was quite unsatisfactory. The incidence of pregnancy'after insertion of the oviduct blocks was quite high. Effective sterilization was only achieved if the plug was placed in I the medial portion of the oviduct. To remove the plug it was necessary to conduct laparotomy'. A further problem which was reported was the tendency for the plug to migrate from the oviduct into either the uterine cavity or even more dangerously into the peritoneal cavity. 7
Rakshit reported in the Calcutta Med J 65, No. 3. (Mar., 1968) attempts to use various materials to block the oviducts to prevent conception. It was suggested to use a plastic material of a nature which solidifies after being mixed with a catalyst to form the oviduct blocks. Rakshit specifically taught however that because of high viscosity the silicone rubbers could not be injected transvaginally and laparotomies were conducted to inject the material directly into the uterus. The material was then allowed to flow into the oviducts. It was suggested in this article by Rakshit that it may be possible to introduce a plastic material transcervically into the uterus and then to allow it to flow in the oviducts. Using this method however the resulting oviduct blocks would have to be removed surgically to reestablish fertility.
Rakshit further reported in Human Sterilization edited by Ralph Rechart (l97l) pages 213-221 the technique of attempting to form oviduct blocks by inserting a cannula directly into the uterus through the cervix and filling the uterus witha curable liquid silicone plastic. The injected silicone plastic was allowed to flow into the oviducts and cure in place to form the desired oviduct blocks. The excess material was then removed from the uterus. The reported results were not promising. On tests reported on 14 women there were nine satisfactory blockages, three doubtful cases and two negative cases. Further, in orderto remove the oviduct blocks it was necessary to conduct a laparotorny.
SUMMARY OF THE INVENTION In accordance with this invention a method and apparatus is provided to form oviduct blocks which prevent conception when in place and can be nonsurgically removed if desires. The apparatus is inserted through the cervical os into the uterus. The tip on the apparatus is then aligned with the uterine end of the oviduct. A mixture of a fluid elastomeric material and a catalyst for polymerizing the elastomeric mixture is injected through an aperture in the tip into the oviduct. The elastomeric material is allowed to solidify and to adhere to the tip. The tip is released so that it remains with the injected elastomeric material to form the oviduct block of this invention. The apparatus is then removed. The oviduct block can be removed nonsurgically by inserting an instrument into the uterus through the cervix which grips the tip of the oviduct block and then withdrawing the oviduct block which restores normal fertility.
BRIEF DESCRIPTION OF THE DRAWING FIG. 1 is an illustration in partial cross-section of an apparatus especially adopted for use in the method of this invention.
FIG. 2 is an illustration in partial cross-section of a uterus, the cervix and a portion of the vagina. The uterus is illustrated with an oviduct block insert in one of the oviduct and the terminal end of the apparatus of FIG. 1 positioned for insertion of an oviduct block into the opposite oviduct.
FIG. 3 is an enlarged illustration taken in partial cross-section of the terminal end of the apparatus of FIG. 1.
FIG. 4 is an illustration in cross-section of the terminal end of the apparatus of FIG. 3 shown with fluid uncured elastomeric material shown in the internal feed tube.
FIG. 5 is an illustration shown in cross-section showing the separation of the tip from the apparatus of FIG. 1.
DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS In the method of this invention an oviduct block is formed in situ in the oviduct. The oviduct block is most preferable formed from a medical inert plastic which has approximately the same modulus of elasticity as the oviduct. The selection of material having the proper modulus of elasticity appears to both' prevent cxplusion of the oviduct block and substantially eliminates any physical discomfort. The materials which have been found most useful in the method of this invention are the commercially available medical grade silicone elastomers. The uncured silicone elastomer in the fluid state is blended with a catalyst for solidifying the elastomer and a dilution fluid to control the viscosity during injection and also to control the modulus of elasticity of the cured solidified material. It is preferable to also include a radiopaque material in the mixture to facilitate the placement of the oviduct block and to facilitate removal of the oviduct block if desires.
A tip is molded from an inert plastic material to which the injected elastomeric material will adhere on solidification. In this regard it should be noted that silicone-rubber is ideally suited for this purpose when a silicone elastomer is used for formation of the oviduct block. I
As shown in the drawing the portion of the tip 10 which will be in contact with uterine end of the oviduct 12 has a spherical configuration. The tip 10 has an aperture 14 which extends throughout the entire length of the tip 14. In addition the tip as illustrated has a-series of annular piston rings 16 molded into the interior portion surface of the aperture 14. The tip 10 further includes a loop 18 which is preferably a thread of a material which is inert in uterine fluids, such as nylon.
The apparatus 20 shown in FIG. 1 is specifically designed for use in the method of this invention. The apparatus 20 includes a tubular extension 22, a dispensing apparatus 24, and a control handle 26 for both operating the dispensing means and positioning the tip 10 on the end of the tubular extension 22.
The tubular extension 22 has a rigid section which is adjacent to the control handle 26. The opposite terminal end portion 28 on which the tip 10 is secured is flexible. One end of each control wire 30, 32 is attached to the end portion of the flexible section 28. The control wires 30, 32 are connected at their opposite ends to a pair of separately controlled drums 34 (only one drum is shown) mounted on the control hand 26. By adjustment of the drums 34 to either to collect or release the wires 30, 32 the position of the tip 10 can be adjusted and bent in a curved configuration shown in FIG. 2.
At the flexible terminal end 28 a metal connector 36 'is provided which has annular piston ring 38 which mates with the piston rings 16 on the tip 10. The metal connector '36 further has defined in it a constricted area having a sharp cut off portion 40.
A tube 42 extends from the dispensing means 24, through the tubular extension 22 to the aperture 14 in the tip 10.
The dispensing means 24 consists of a mixing syringe 44 in which the plunger 46 is adapted to provide mixing of a fluid elastermeric material, a catalyst and other additive as may be required. The syringe 44 is mounted on top of the control handle 26 with the plunger 46 in contact with a rack 48 and a pivotal mounted pawl 50. The pawl 50 is connected to a trigger 52. Squeezing the trigger 52 causes the plunger 46 to be advanced within the syringe 46 and material within thesyringe 44 to be dispensed through the tube 42 to the tip 10.
In the method of this invention the tip 10 is inserted over the end of the flexible portion 28 of the tubular extension. The tip 10 being premolded of asilicone rubher is somewhat elastic and deforms somewhat until the piston ring 16 of the tip of 10 engages and locks with the mating piston rings 38.
The tubular extension 20 with tip 10 installed is inserted into the vagina 54, through the cervical os 56 into the uterine cavity 58. Then, preferably using flouroscopic techniques, the tip 10 is aligned with the uterine end of one of the oviducts 12. It should be noted that because of the shape of the uterine cavity 58 thetip can be guided blindly in the proper position. The relative position of the flexible end 28 is controlled by adjustment of the drums 34.
Once the tip 10 is in position the fluid mixture of the elastomer, catalyst and other additives are injected through the tube 42 to the tip 10 by operation of the trigger 52 as noted above. The uncured fluid elastomeric mixture 60 flows through the aperture 14 in the tip 10 and then into the oviduct 12. A sufficient amount of the mixture is injected to fill approximately one third or more of the length of the oviduct 12. Some of the material will flow back around the tip 10 so that the surface of the tip 10 will conform to the shape of the uterine end of the oviduct 12 as shown in the tip 10 as modified 62 which is shown in FIG. 5.
stripped from the terminal end as shown in phantom in FIG. 5.
The procedure noted above is repeated for the opposite oviduct to complete the sterilization procedure.
The solidified oviduct blocks each has a configuration which conforms to the interior of the oviduct in which it is cast, thus effectively preventing conception.
The oviduct block can remain in place until it is desired to remove it. The use of a material having approximately the same modulus of elasticity as the oviducts assists in maintaining the oviduct blocks 64 in position. The natural convolution of the oviduct likewise results in stabilization of the oviduct blocks 64. The tip 10 serves a most important function of preventing the oviduct block 64 from migrating into the intraperitoneal cavity, a problem that was a serious and relatively common problem with othersimilar prior art technique.
As noted above the oviduct block is inserted nonsurgically. The method is relatively simple to learn by those skilled in the medical art. The time required is likewise quite short with a skilled person being able to block both oviducts in about 15 to 30 minutes.
As noted above the oviduct block can be removed nonsurgically if desired. An instrument of the type shown in FIG. 1 is used for this purpose. The tip 10 is replaced with a hooked member which is adapted to engage the loop 18. Once the loop 18 is engaged the oviduct block 64 is withdrawn. It is also possible to use a pronged member to grip the tip and then pull out the oviduct block.
Both the insertion and removal of the oviduct block 64 are relatively painless. However a local anesthetic can be used if desired.
The effectiveness of the contraception method of this invention was found to be excellent. On rabbit tests it was found that the method is 100% effective if the oviduct blocks are properly placed. In further rabbit tests it was found that after the oviduct blocks were removed that fertility was restored. There was no indication of explusion of the oviduct blocks either in the uterine cavity or in the int'raperitoneal cavity. Histologic examv, ination and scanning election microscopic examination have not indicated that there is any adverse reaction to the tissue of the oviducts.
The apparatus of this invention has been described in preferred embodiment. It should be appreciated that the various modifications can be made. to the apparatus without departing from'the scope of this invention. For
example, the control handle 26 has been provided to sisting of the trigger 52, rack 48 and pawl 50, could likewise be removed and the syringe operated manually. Furthermore, the configuration of the tip 10 can be modified to a different shape such as a conical configuration of other suitable shapes and still be satisfactory for use in this invention. These and other modifications which would be obvious to those skilled in the art are included within the scope of the subjoined claims.
I claim: 1. The method of forming non-surgically removable oviduct block in a female comprising the step of a. providing a shaped tip member having an aperture defined therein; said tip memlber having a configuration such as to fit in substantial sealing contact adjacent to the uterine end of the oviduct of said female, and having a size larger than the lumen of said oviduct; said tip member being formed from a given cured elastomeric material b. positioning said tip member within the uterine cavity of said female adjacent to the uterine end of said oviduct with the aperture of said tip member being in axial alignment with the lumen of said oviduct c. injecting through the aperture of said tip member into the lumen of said oviduct a mixture of a fluid self curing elastomeric material which will solidify in said oviduct and adhere to said tip member, said elastomeric material being injected into said oviduct in an amount sufficient to block the passage of ovum through said oviduct to the uterine cavity d. and thereafter allowing said uncured elastomeric material to cure to a solidified mass while in contact with said tip member whereby an oviduct block is formed wherein the tip member remains within the uterine cavity where it can be gripped by mechanical means to remove the oviduct block non-surgically.
2. The method according to claim 1 wherein said tip member further includes a loop member whereby said loop member can be gripped to non-surgically remove said oviduct block.
3. The method according to claim 1 wherein said selfcuring elastomeric material is a self-curing silicone elastomer. y
4. The method according to claim 1 wherein said selfcuring elastomeric material when solidified has a modulus of elasticity substantially the same as said oviduct.
5. The apparatus for forming the oviduct block according to claim 1, said apparatus comprising: a tubular means of a length sufficient to extend from vagina area of said female to the uterine ends of said oviducts and having a diameter sufficiently small to pass through the cervix of said female; said tubular means having first and second terminal ends; said first terminal end having an apertured tip member detachably connected thereto and also means for releaseably holding and ejecting said tip member, said tubular member including means for positioning said first terminal end with said tip member thereon adjacent the uterine end of said oviduct, and said tubular member further including means for transmission of said self curing elastomeric material from a point adjacent to the second terminal end toand through said aperture in said 'tip member secured to the first terminal end.
6. The apparatus of claim 5 in which the first terminal end portion is flexible. 1
7. The apparatus according to claim 5 in which the position of the first terminal end is controlled by means operable from the second terminal end.
from said slideable member.
9. The apparatus according to claim 5 wherein the dispensing means is a syringe having a barrel and a plunger and wherein the plunger is advanceable within the barrel by a rack and paw] drive operated from the second terminal end.
|Cited Patent||Filing date||Publication date||Applicant||Title|
|US3042030 *||Nov 25, 1958||Jul 3, 1962||Read Thane||Spherical type insert plug for body passageway and tool therefor|
|US3182662 *||Jul 25, 1962||May 11, 1965||Shirodkar Vithal N||Plastic prosthesis useful in gynaecological surgery|
|US3422813 *||Jun 21, 1965||Jan 21, 1969||Dow Corning||Method for sterilization of males|
|US3648683 *||Jun 29, 1970||Mar 14, 1972||Brodie Nathan||Reversible intra-vas device|
|US3680542 *||May 11, 1970||Aug 1, 1972||Cimber Hugo S||Device for occlusion of an oviduct|
|US3707146 *||Mar 7, 1967||Dec 26, 1972||Prod Res & Chem Corp||Means to inject a plastic into a cavity to produce a replica thereof|
|Citing Patent||Filing date||Publication date||Applicant||Title|
|US3871374 *||Sep 6, 1973||Mar 18, 1975||Population Res Inc||Dispensing instrument|
|US3875939 *||Jan 31, 1974||Apr 8, 1975||Population Res Inc||Single stroke dispensing method|
|US3918431 *||Jan 11, 1974||Nov 11, 1975||Sinnreich Manfred||Fallopian tube obturating device|
|US3948259 *||Mar 15, 1974||Apr 6, 1976||Population Research Incorporated||Dispensing instrument|
|US3972331 *||Jan 24, 1975||Aug 3, 1976||Population Research Incorporated||Dispensing catheter|
|US4245623 *||Jun 6, 1978||Jan 20, 1981||Erb Robert A||Method and apparatus for the hysteroscopic non-surgical sterilization of females|
|US4271845 *||Jul 2, 1979||Jun 9, 1981||Kabushiki Kaisha Medos Kenkyusho||Device for bending a medical instrument inserted into the body cavity|
|US4273131 *||Jun 18, 1979||Jun 16, 1981||Auburn Enterprises, Inc.||Surgical stylet|
|US4363318 *||Jul 30, 1981||Dec 14, 1982||University Patents, Inc.||Custom valved cervical cap|
|US4365632 *||Dec 12, 1979||Dec 28, 1982||Kortum William M||Method and apparatus for inducing immunological and resistant response in mammary glands|
|US4446578 *||Mar 8, 1982||May 8, 1984||Perkins Ezra C||Joint treatment|
|US4601698 *||Sep 17, 1984||Jul 22, 1986||Moulding Jr Thomas S||Method of and instrument for injecting a fluid into a uterine cavity and for dispersing the fluid into the fallopian tubes|
|US4637818 *||Nov 18, 1985||Jan 20, 1987||Johnson Richard K||Apparatus for producing sterility in female animals|
|US4700701 *||Oct 23, 1985||Oct 20, 1987||Montaldi David H||Sterilization method and apparatus|
|US4805618 *||Apr 11, 1988||Feb 21, 1989||Olympus Optical Co., Ltd.||Oviduct closing apparatus|
|US5217466 *||Apr 19, 1991||Jun 8, 1993||Hasson Harrith M||Guide for facilitating the performance of internal surgery|
|US5342394 *||Nov 20, 1992||Aug 30, 1994||Olympus Optical Co., Ltd.||Apparatus for blocking a vein branch and method of blocking a vein branch|
|US5368598 *||Jun 7, 1993||Nov 29, 1994||Hasson; Harrith M.||Method of manipulating an uterus using a bendable manipulator|
|US5555896 *||Sep 22, 1995||Sep 17, 1996||Cimber; Hugo||Intrauterine contraceptive device|
|US5795353 *||Nov 2, 1996||Aug 18, 1998||Advanced Bio Surfaces, Inc.||Joint resurfacing system|
|US5954715 *||Apr 20, 1998||Sep 21, 1999||Adiana, Inc.||Method and apparatus for tubal occlusion|
|US6068626 *||Aug 10, 1999||May 30, 2000||Adiana, Inc.||Method and apparatus for tubal occlusion|
|US6145505 *||May 28, 1999||Nov 14, 2000||Conceptus, Inc.||Electrically affixed transcervical fallopian tube occlusion devices|
|US6176240||Jun 7, 1995||Jan 23, 2001||Conceptus, Inc.||Contraceptive transcervical fallopian tube occlusion devices and their delivery|
|US6346102||May 26, 2000||Feb 12, 2002||Adiana, Inc.||Method and apparatus for tubal occlusion|
|US6526979||Jun 12, 2000||Mar 4, 2003||Conceptus, Inc.||Contraceptive transcervical fallopian tube occlusion devices and methods|
|US6634361||Jun 1, 1999||Oct 21, 2003||Conceptus, Inc.||Contraceptive transcervical fallopian tube occlusion devices and methods|
|US6679266||Mar 28, 2002||Jan 20, 2004||Conceptus, Inc.||Contraceptive transcervical fallopian tube occlusion devices and their delivery|
|US6684884||Jul 23, 2001||Feb 3, 2004||Conceptus, Inc.||Contraceptive transcervical fallopian tube occlusion devices and methods|
|US6705323||Jun 8, 1998||Mar 16, 2004||Conceptus, Inc.||Contraceptive transcervical fallopian tube occlusion devices and methods|
|US6709667||Aug 22, 2000||Mar 23, 2004||Conceptus, Inc.||Deployment actuation system for intrafallopian contraception|
|US6712810||Mar 16, 2001||Mar 30, 2004||Adiana, Inc.||Method and apparatus for tubal occlusion|
|US6726682||Feb 12, 2002||Apr 27, 2004||Adiana, Inc.||Method and apparatus for tubal occlusion|
|US6763833||Aug 22, 2000||Jul 20, 2004||Conceptus, Inc.||Insertion/deployment catheter system for intrafallopian contraception|
|US6871650 *||Jun 12, 2000||Mar 29, 2005||Conceptus, Inc.||Contraceptive transcervical fallopian tube occlusion devices and their delivery|
|US7001431||Feb 13, 2003||Feb 21, 2006||Disc Dynamics, Inc.||Intervertebral disc prosthesis|
|US7077865||Feb 13, 2003||Jul 18, 2006||Disc Dynamics, Inc.||Method of making an intervertebral disc prosthesis|
|US7220259||Apr 26, 2004||May 22, 2007||Adiana, Inc.||Method and apparatus for tubal occlusion|
|US7237552||Jul 15, 2004||Jul 3, 2007||Conceptus, Inc.||Insertion/deployment catheter system for intrafallopian contraception|
|US7428904||May 14, 2004||Sep 30, 2008||Alien Technology Corporation||Contraceptive transcervical fallopian tube occlusion devices and their delivery|
|US7506650||Feb 23, 2004||Mar 24, 2009||Conceptus, Inc.||Deployment actuation system for intrafallopian contraception|
|US7582085||Aug 24, 2004||Sep 1, 2009||Cytyc Corporation||Catheter placement detection system and operator interface|
|US7591268||Jun 15, 2005||Sep 22, 2009||Conceptus, Inc.||Deployment actuation system for intrafallopian contraception|
|US7621276||Aug 23, 2007||Nov 24, 2009||Yale University||Intrauterine fallopian tube occlusion device|
|US7669601||Feb 15, 2006||Mar 2, 2010||Tal Michael G||Intrauterine fallopian tube occlusion device and method for use|
|US7686020||Aug 31, 2006||Mar 30, 2010||Conceptus, Inc.||Contraceptive transcervical fallopian tube occlusion devices and methods|
|US7713301||Mar 29, 2006||May 11, 2010||Disc Dynamics, Inc.||Intervertebral disc prosthesis|
|US7766965||Jun 30, 2006||Aug 3, 2010||Disc Dynamics, Inc.||Method of making an intervertebral disc prosthesis|
|US7771357||Jun 10, 2003||Aug 10, 2010||Vascular Control Systems, Inc.||Devices and methods for occlusion of the uterine arteries|
|US7842035||Mar 29, 2004||Nov 30, 2010||Cytyc Corporation||Method and apparatus for tubal occlusion|
|US7905880||May 22, 2007||Mar 15, 2011||Cytyc Corporation||Method and apparatus for tubal occlusion|
|US7921848||Aug 13, 2003||Apr 12, 2011||Conceptus, Inc.||Contraceptive transcervical fallopian tube occlusion devices and methods|
|US7934504||Jul 21, 2009||May 3, 2011||Conceptus, Inc.||Deployment actuation system for intrafallopian contraception|
|US7975697||May 11, 2006||Jul 12, 2011||Conceptus, Inc.||Methods and apparatus for occluding reproductive tracts to effect contraception|
|US8048086||Feb 24, 2005||Nov 1, 2011||Femasys Inc.||Methods and devices for conduit occlusion|
|US8048101||Sep 29, 2008||Nov 1, 2011||Femasys Inc.||Methods and devices for conduit occlusion|
|US8052669||Sep 29, 2008||Nov 8, 2011||Femasys Inc.||Methods and devices for delivery of compositions to conduits|
|US8066007||Jul 31, 2006||Nov 29, 2011||Conceptus, Inc.||Contraceptive transcervical fallopian tube occlusion devices and their delivery|
|US8079364||Mar 28, 2011||Dec 20, 2011||Conceptus, Inc.||Deployment actuation system for intrafallopian contraception|
|US8100129||Aug 28, 2007||Jan 24, 2012||Conceptus, Inc.||Methods and devices for occluding an ovarian pathway|
|US8171936||Oct 20, 2010||May 8, 2012||Conceptus, Inc.||Contraceptive transcervical fallopian tube occlusion devices and methods|
|US8181653||Jan 14, 2009||May 22, 2012||Yale University||Intrauterine fallopian tube occlusion device|
|US8217219||Dec 29, 2003||Jul 10, 2012||Kimberly-Clark Worldwide, Inc.||Anatomically conforming vaginal insert|
|US8226645||Oct 26, 2010||Jul 24, 2012||Cytyc Corporation||Apparatus for tubal occlusion|
|US8231619||Jan 22, 2010||Jul 31, 2012||Cytyc Corporation||Sterilization device and method|
|US8316853||Jul 17, 2009||Nov 27, 2012||Femasys Inc.||Method and devices for conduit occlusion|
|US8316854||Oct 31, 2011||Nov 27, 2012||Femasys Inc.||Methods and devices for conduit occlusion|
|US8324193||Oct 31, 2011||Dec 4, 2012||Femasys Inc.||Methods and devices for delivery of compositions to conduits|
|US8327852||Nov 11, 2011||Dec 11, 2012||Conceptus, Inc.||Occlusion devices and methods|
|US8336552||Oct 31, 2011||Dec 25, 2012||Femasys Inc.||Methods and devices for conduit occlusion|
|US8356599||Nov 11, 2011||Jan 22, 2013||Conceptus, Inc.||Occlusion devices and methods|
|US8381733||Nov 11, 2011||Feb 26, 2013||Conceptus, Inc.||Deployment actuation system|
|US8506543||Jun 11, 2012||Aug 13, 2013||Kimberly-Clark Worldwide, Inc.||Anatomically conforming vaginal insert|
|US8550085||Jun 30, 2011||Oct 8, 2013||Conceptus, Inc.||Methods and apparatus for occluding reproductive tracts to effect contraception|
|US8550086||May 4, 2010||Oct 8, 2013||Hologic, Inc.||Radiopaque implant|
|US8584679||Feb 8, 2012||Nov 19, 2013||Conceptus, Inc.||Deployment actuation system|
|US8613282||May 7, 2012||Dec 24, 2013||Conceptus, Inc.||Occlusion devices and methods|
|US8662081||Aug 16, 2010||Mar 4, 2014||Yale University||Intrauterine device|
|US8695604||May 10, 2012||Apr 15, 2014||Bayer Essure Inc.||Deployment actuation system|
|US8695606||Nov 24, 2012||Apr 15, 2014||Femasys Inc.||Methods and devices for conduit occlusion|
|US8702727||Nov 22, 2006||Apr 22, 2014||Hologic, Inc.||Delivery catheter with implant ejection mechanism|
|US8726905||Jan 20, 2012||May 20, 2014||Bayer Essure Inc.||Methods and devices for occluding an ovarian pathway|
|US8726906||Nov 25, 2012||May 20, 2014||Femasys Inc.||Methods and devices for conduit occlusion|
|US8733360||Aug 20, 2012||May 27, 2014||Bayer Essure Inc.||Occlusion devices and methods|
|US8733361||Nov 19, 2012||May 27, 2014||Bayer Essure Inc.||Occlusion devices and methods|
|US8851077||May 20, 2013||Oct 7, 2014||Hologic, Inc.||Methods and apparatus for occlusion of body lumens|
|US8984733||Oct 2, 2013||Mar 24, 2015||Artventive Medical Group, Inc.||Bodily lumen occlusion|
|US9016280||Apr 18, 2012||Apr 28, 2015||Yale University||Intrauterine fallopian tube occlusion device|
|US9017351||Jun 29, 2010||Apr 28, 2015||Artventive Medical Group, Inc.||Reducing flow through a tubular structure|
|US9034053||Nov 24, 2012||May 19, 2015||Femasys Inc.||Methods and devices for conduit occlusion|
|US9060773||Dec 16, 2011||Jun 23, 2015||Covidien Lp||Occlusive implant delivery devices and associated methods|
|US9095344||Mar 14, 2013||Aug 4, 2015||Artventive Medical Group, Inc.||Methods and apparatuses for blood vessel occlusion|
|US9107669||May 19, 2014||Aug 18, 2015||Artventive Medical Group, Inc.||Blood vessel occlusion|
|US9149277||Oct 18, 2010||Oct 6, 2015||Artventive Medical Group, Inc.||Expandable device delivery|
|US9180039||Nov 10, 2011||Nov 10, 2015||Yale University||Intrauterine device|
|US9220880||Nov 25, 2012||Dec 29, 2015||Femasys Inc.||Methods and devices for delivery of compositions to conduits|
|US9238127||Sep 19, 2013||Jan 19, 2016||Femasys Inc.||Methods and devices for delivering to conduit|
|US9247942||Feb 6, 2012||Feb 2, 2016||Artventive Medical Group, Inc.||Reversible tubal contraceptive device|
|US9308023||May 6, 2015||Apr 12, 2016||Femasys Inc.||Methods and devices for conduit occlusion|
|US9402762||Mar 31, 2014||Aug 2, 2016||Femasys Inc.||Methods and devices for conduit occlusion|
|US9451965||Apr 16, 2015||Sep 27, 2016||Artventive Medical Group, Inc.||Reducing flow through a tubular structure|
|US9492291||Mar 28, 2014||Nov 15, 2016||Kunovus Pty Ltd.||Systems, methods and apparatuses for formation and insertion of tissue prosthesis|
|US9492311||Aug 13, 2014||Nov 15, 2016||Yale University||Intrauterine device|
|US9510088||Jul 24, 2013||Nov 29, 2016||Yale University||Intrauterine device|
|US20030195628 *||Feb 13, 2003||Oct 16, 2003||Qi-Bin Bao||Method of making an intervertebral disc prosthesis|
|US20030220649 *||Feb 13, 2003||Nov 27, 2003||Qi-Bin Bao||Intervertebral disc prosthesis|
|US20040079377 *||Jun 20, 2003||Apr 29, 2004||Conceptus, Inc.||Contraceptive transcervical fallopian tube occlusion devices and methods|
|US20040127918 *||Aug 13, 2003||Jul 1, 2004||Conceptus, Inc.||Contraceptive transcervical fallopian tube occlusion devices and methods|
|US20040159324 *||Feb 12, 2004||Aug 19, 2004||Conceptus, Inc.||Contraceptive transcervical fallopian tube occlusion devices and their delivery|
|US20040163650 *||Feb 23, 2004||Aug 26, 2004||Conceptus, Inc.||Deployment actuation system for intrafallopian contraception|
|US20040163651 *||Feb 23, 2004||Aug 26, 2004||Conceptus, Inc.||Transcervical fallopian tube occlusion devices and their delivery|
|US20040204720 *||Apr 26, 2004||Oct 14, 2004||Adiana, Inc.||Method and apparatus for tubal occlusion|
|US20040206358 *||May 14, 2004||Oct 21, 2004||Conceptus, Inc., A California Corporation||Contraceptive transcervical fallopian tube occlusion devices and their delivery|
|US20040211429 *||May 14, 2004||Oct 28, 2004||Conceptus, Inc.||Contraceptive transcervical fallopian tube occlusion devices and their delivery|
|US20040255958 *||Mar 29, 2004||Dec 23, 2004||Adiana, Inc.||Method and apparatus for tubal occlusion|
|US20050033281 *||Aug 24, 2004||Feb 10, 2005||Adiana, Inc.||Catheter placement detection system and operator interface|
|US20050061329 *||Sep 18, 2003||Mar 24, 2005||Conceptus, Inc.||Catheter for intrafallopian contraceptive delivery|
|US20050148995 *||Dec 29, 2003||Jul 7, 2005||Kimberly-Clark Worldwide, Inc.||Anatomically conforming vaginal insert|
|US20050232961 *||Jun 15, 2005||Oct 20, 2005||Conceptus, Inc.||Deployment actuation system for intrafallopian contraception|
|US20060144406 *||Mar 2, 2006||Jul 6, 2006||Nikolchev Julian N||Contraceptive transcervical fallopian tube occlusion devices and methods|
|US20070000496 *||Aug 31, 2006||Jan 4, 2007||Nikolchev Julian N||Contraceptive transcervical fallopian tube occlusion devices and methods|
|US20070023534 *||Jul 24, 2006||Feb 1, 2007||Mingsheng Liu||Water-source heat pump control system and method|
|US20070038300 *||Mar 29, 2006||Feb 15, 2007||Disc Dynamics, Inc.||Intervertebral disc prosthesis|
|US20070044808 *||Jul 31, 2006||Mar 1, 2007||Conceptus, Inc., A California Corporation||Contraceptive transcervical fallopian tube occlusion devices and their delivery|
|US20070062542 *||Nov 20, 2006||Mar 22, 2007||Nikolchev Julian N||Contraceptive transcervical fallopian tube occlusion devices and methods|
|US20070144528 *||Feb 26, 2007||Jun 28, 2007||Julian Nikolchev||Contraceptive transcervical fallopian tube occlusion devices and their delivery|
|US20070215163 *||May 22, 2007||Sep 20, 2007||Adiana, Inc.||Method and Apparatus for Tubal Occlusion|
|US20070261699 *||May 11, 2006||Nov 15, 2007||Callister Jeffrey P||Methods and Apparatus for Occluding Reproductive Tracts to Effect Contraception|
|US20080047563 *||Aug 23, 2007||Feb 28, 2008||Tal Michael G||Intrauterine fallopian tube occlusion device|
|US20080178889 *||Feb 15, 2006||Jul 31, 2008||Tal Michael G||Intrauterine Fallopian Tube Occlusion Device and Method For Use|
|US20090036840 *||Sep 25, 2008||Feb 5, 2009||Cytyc Corporation||Atraumatic ball tip and side wall opening|
|US20090056722 *||Aug 28, 2007||Mar 5, 2009||Betsy Swann||Methods and devices for occluding an ovarian pathway|
|US20090125023 *||Nov 13, 2007||May 14, 2009||Cytyc Corporation||Electrosurgical Instrument|
|US20090178682 *||Jan 14, 2009||Jul 16, 2009||Tal Michael G||Intrauterine fallopian tube occlusion device|
|US20090277463 *||Jul 21, 2009||Nov 12, 2009||Conceptus, Inc., A California Corporation||Deployment Actuation System for Intrafallopian Contraception|
|US20100063360 *||Nov 28, 2006||Mar 11, 2010||Adiana, Inc.||Side-arm Port Introducer|
|US20100086492 *||Oct 3, 2008||Apr 8, 2010||Kathy Lee-Sepsick||Methods and devices for sonographic imaging|
|US20100094074 *||Oct 10, 2008||Apr 15, 2010||Hologic Inc.||Brachytherapy apparatus and methods employing expandable medical devices comprising fixation elements|
|US20110030696 *||Oct 20, 2010||Feb 10, 2011||Nikolchev Julian N||Contraceptive transcervical fallopian tube occlusion devices and methods|
|US20110125158 *||May 1, 2008||May 26, 2011||Ashish Dhar Diwan||Systems, methods and apparatuses for formation and insertion of tissue prostheses|
|US20110180073 *||Jan 22, 2010||Jul 28, 2011||David Callaghan||Sterilization Device and Method|
|EP0010812A1 *||Oct 26, 1979||May 14, 1980||Karel Johan Hendrik Verschoof||Contraceptive device|
|EP0891757A2 *||Jul 17, 1998||Jan 20, 1999||Gynecare, Inc.||Tubular fallopian sterilization device|
|EP0891757A3 *||Jul 17, 1998||Dec 22, 1999||Gynecare, Inc.||Tubular fallopian sterilization device|
|EP1366729A2 *||May 21, 1996||Dec 3, 2003||Conceptus, Inc.||Contraceptive transcervical fallopian tube occlusion devices having mechanical fallopian tube attachment|
|EP1366729A3 *||May 21, 1996||Dec 10, 2003||Conceptus, Inc.||Contraceptive transcervical fallopian tube occlusion devices having mechanical fallopian tube attachment|
|EP1541101A2||Sep 23, 1998||Jun 15, 2005||Conceptus, Inc.||Contraceptive transcervical fallopian tube occlusion devices|
|EP1561427A1||May 21, 1996||Aug 10, 2005||Conceptus, Inc.||Electrically expandable contraceptive transcervical fallopian tube occlusion devices having mechanical fallopian tube attachment|
|EP2260800A2||Sep 23, 1998||Dec 15, 2010||Conceptus, Inc.||Contraceptive transcervical fallopian tube occlusion devices|
|EP2904998A1 *||Apr 24, 2012||Aug 12, 2015||Urogyn B.V.||Occluding compound for a fallopian tube|
|WO1996040023A1 *||May 21, 1996||Dec 19, 1996||Conceptus, Inc.||Contraceptive transcervical fallopian tube occlusion devices and their delivery|
|WO1996040024A1 *||May 21, 1996||Dec 19, 1996||Conceptus, Inc.||Contraceptive transcervical fallopian tube occlusion devices having mechanical fallopian tube attachment|
|WO1998055046A1||Apr 20, 1998||Dec 10, 1998||Adiana, Inc.||Method and apparatus for tubal occlusion|
|WO1999015116A1||Sep 23, 1998||Apr 1, 1999||Conceptus, Inc.||Contraceptive transcervical fallopian tube occlusion devices and methods|
|WO2000033724A2 *||Nov 24, 1999||Jun 15, 2000||Hysterx, Inc.||Devices and methods for occlusion of the uterine arteries|
|WO2000033724A3 *||Nov 24, 1999||Aug 10, 2000||Hysterx Inc||Devices and methods for occlusion of the uterine arteries|
|U.S. Classification||128/831, 606/135, 128/840|
|International Classification||A61F6/00, A61B19/00, A61F6/22|
|Jul 1, 1987||AS02||Assignment of assignor's interest|
Owner name: CALSPAN CORPORATION, AN OH CORP.
Owner name: FRANKLIN INSTITUTE, 20TH STREET AND THE PARKWAY, P
Effective date: 19860604
|Jul 1, 1987||AS||Assignment|
Owner name: FRANKLIN INSTITUTE, 20TH STREET AND THE PARKWAY, P
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST.;ASSIGNOR:CALSPAN CORPORATION, AN OH CORP.;REEL/FRAME:004747/0260
Effective date: 19860604
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:CALSPAN CORPORATION, AN OH CORP.;REEL/FRAME:004747/0260
Owner name: FRANKLIN INSTITUTE, PENNSYLVANIA
|Mar 7, 1985||AS||Assignment|
Owner name: CALSPAN CORPORATION, 4455 GENESSE ST., BUFFALO, NY
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST.;ASSIGNOR:FRANKLIN INSTITUTE;REEL/FRAME:004379/0744
Effective date: 19850109