Search Images Maps Play YouTube News Gmail Drive More »
Sign in
Screen reader users: click this link for accessible mode. Accessible mode has the same essential features but works better with your reader.

Patents

  1. Advanced Patent Search
Publication numberUS3807400 A
Publication typeGrant
Publication dateApr 30, 1974
Filing dateJun 26, 1972
Priority dateJul 17, 1971
Also published asCA999202A1
Publication numberUS 3807400 A, US 3807400A, US-A-3807400, US3807400 A, US3807400A
InventorsCocozza S
Original AssigneeIsf Spa
Export CitationBiBTeX, EndNote, RefMan
External Links: USPTO, USPTO Assignment, Espacenet
Inhaling device for medicinal powder compositions
US 3807400 A
Abstract
This invention is concerned with some improvements in the inhaling devices with whirling chamber, devices that may be considered in their essential operation per se known and are intended to disperse the contents of a capsule filled with a powder medicinal composition.
Images(1)
Previous page
Next page
Claims  available in
Description  (OCR text may contain errors)

United States Patent [1 1 Cocozza Apr. 30, 1974 INHALING DEVICE FOR MEDICINAL POWDER COMPOSITIONS [75] Inventor: Salvatore Cocozza, Milano, Italy [73] Assignee: I. S. F. S.p.A., Milano, Italy [22] Filed: June 26, 1972 [21] Appl. No.: 266,243

[30] Foreign Application Priority Data July 17, 1971 Italy 26971/71 [52] US. Cl 128/266, 128/206, 128/208 [51] Int. Cl A6lm 13/00 [58] Field of Search 128/266, 206, 208, 272;

[56] References Cited UNITED STATES PATENTS 2,573,918 11/1958 McCuiston 128/206 3,507,277 4/1970 Altounyan et a1. 128/208 3,518,992 7/1970 Altounyan et a1. 128/208 3,635,219 1/1972 Altounyan et al. 128/266 3,669,113 6/1972 Altounyan et a1. 128/266 FOREIGN PATENTS OR APPLICATIONS 208,211 12/1967 U.S.S.R 128/266 Primary ExaminerAldrich F. Medbery Attorney, Agent, or Firm--Eric H. Waters [57] ABSTRACT This invention is concerned with some improvements in the inhaling devices with whirling chamber, devices that may be considered in their essential operation per se known and are intended to disperse the contents of a capsule filled with a powder medicinal composition,

'number of piercing operations to both piercing devices.

2 Claims, 7 Drawing Figures INHALING DEVICE FOR MEDICINAL POWDER COMPOSITIONS FIELD OF THE INVENTION The present invention relates to improvements in or modifications of inhaling devices for'medicinal powder compositions in capsule form.

SUMMARY OF THE INVENTION It is an object of the present invention to provide an inhaling device of economical construction, of high efficiency which is able to be used by any category of patients and for any kind of powder compositions contained in capsules.

It is a further object of the present invention to provide a compact inhaling device of substantially reduced overall dimension as compared with known devices for use with medicinal powder composition capsule form.

According to the present invention, there is provided an inhaling device for medicinal powder compositions provided in capsule form comprising, in combination, a disc-shaped lower member provided with a cavity in which the said capsule is to be located, which cavity is formed in an upwardly extending platform of said member, and at least one piercing member for said capsule, which piercing member is resiliently biased away from said capsule and projects from said platform, an upper member formed with a number of tangential passages, said upper member providing a lower edge to provide a cam which is able to reciprocate said piercing member against the action of a spring in order to pierce said capsule, the upper member being provided with a telescopically extendable mouthpiece, whirling chamher being defined in the region of the extended mouthpiece.

BRIEF DESCRIPTION OF THE DRAWINGS The invention will be further illustrated, by way of example, with reference to the accompanying drawings, in which: I

FIG. 1 is a side view of an inhaling device in accordance with the invention in its inactive or retracted position;

FIG. 2 is a side view of an inhaling device in accordance with the invention in it active or operative position;

FIG. 3 is a top plan view of the inhaling device shown in FIGS. 1 and 2;

FIG. 4 is a radial partial sectional view of the inhaling device of the invention;

FIGS. 5 and 6, on the same scale as FIG. 1, are respectively the bottom view and the top view of the upper and lower component forming the upper member of the inhaling device in accordance with the invenber 31 which is formed with an upwardly extending platform, wherein a cavity 40 is provided for receiving a capsule 45 filled with a suitable medicinal powder composition. The lower member 31 also contains the piercing device which is housed in the said platform as will be explained in more detail hereinafter.

"ll'teupper member comprising two components 1 and 2, together with the lower member 31 forms a mixing chamber W for the contents of the pierced capsule, which are subjected to a whirling action therein.

The central top portion of the upper member 1 has supported therein a plurality of telescopically movable integral sleeve members, which upon being extended outwardly, form the mixing chamber W.

The component 2 is formed with trapezoidally profiled ribs 4 which define therebetween tangential passages 61 (see FIG. 6), and the component 1 (see FIG.

which extend in the assembled position into the said tangential passages or gaps 61. Component 1 is provided with a set of pins 3 (see FIGS. 4 and 5 which c0- operate with, and on the same transverse side of, the gaps formed by the tangential passage 61, whereby the two components 1 and 2 are precisely positioned with one another in the assembled position. Secure connection of the two components 1 and 2 is effected by the provision of suitable adhesive means at 29.

In operation, the mouthpiece of the inhaling device of the invention is telescopically extendable by means of sleeve members 12, 13 and 14. The member 12 is formed with outlet openings 52 for the powder to be inhaled. A net of plastics material is adhesively connected to the lower end of the mouthpiece 12 and operates as'a screen 53, preventing the capsule debris passing to the mouthpiece l2.

The component 2 is formed with a peripheral downwardly projecting skirt the inside surface of which is provided with inwardly extending profiled projections 50 which act as cams with profiled recesses 69 for actuating the piercing device P, both represented in dotted lines inFIG. 7. The piercing device will be hereinafter illustrated with reference to FIGS. 4 and 7. A piercing needle 8 for the capsule is'housed in a radial recess 40 of the plat-' form of the lower member 31 and is urged away from the capsule by means of a spring 9. The needle terminates with a push-button 10 which co-operates with the cams 50 and recesses 69, and the said push-button 10 may be held in its maximum radially extending position by a ring 51 which is frictionally mounted around the platform of the lower member 31.

A plurality of knurled portions 57 may be provided in the lower member 31 of the inhaling device 30 to facilitate grasping of the device by a user.

In order to obtain two diametrally opposed perforations in the capsule 45, two diametrally opposed piercing devices P are provided.

Operation of the inhaling device of the invention is as follows:

After having separated the lower member 31 from the upper member (comprising components 1 and 2) the capsule is placed in the cavity 40 provided in the upwardly extending platform of the lower member 31 thereafter the lower member 31 is frictionally secured to the upper member, by the reaction of the said springs 9 against the said skirt. Upon relative rotational movement between the upper and lower members, the cams and recesses 69 cause a number of reciprocations of the needle 8 and, therefore a number of piercing operations of the capsule in diametrally opposed positions is effected. The patient, with the mouthpiece already telescopically extended causes, by aspiration, a displacement and movement of the capsule into the extended mixing or whirling chamber and, therefore, the medicinal powder composition is dispersed into the said chamber and is finally inhaled into the patients mouth. It can be seen that the powder composition traverses, prior to inhalation by the patient, the filter screen 53 and the openings 52 moulded in the central telescopic member 12.

The preceding description makes it evident that the mentioned objects of the invention have been fully attained. In the light of the disclosure changes and modifications within the true spirit and scope of the invention will occur to others, and accordingly it is not desired that the scope of the invention be restricted except as is required by the appended claims.

What I claim is:

1. An inhaling device for medicinal powder compositions provided in capsule form comprising, in combination: a disc shaped lower platform member provided with a cavity in which the said capsule is to be located, and at least one piercing member for said capsule projecting from the said platform, a spring for biasing the piercing member from said capsule and projecting it from said platform, an upper member, formed with a number of tangential passages extending from the outside to the interior thereof said upper member having a recess providing a peripheral cam shaped wall portion for actuating said piercing member against the action of a spring in order to pierce said capsule, the upper member being provided with an outwardly telescopically extendable sleeve means, including a mouth engaging portion, which when extended defines a whirling chamber for said capsule and its medicinal powder contents.

2. An inhaling device as claimed in claim 1, in which the upper member comprises an upper and a lower component, connected together by adhesive means and together defining the tangential passages, the upper component including a plurality of pins uniformly and radially spaced in like manner as the tangential passages and of the same size thereof, whereupon, in the assembled position, the pins co-operate with the tangential passages so that the mutual disposition of both components is exactly located before adhesively securing the two components together.

Patent Citations
Cited PatentFiling datePublication dateApplicantTitle
US2573918 *Nov 5, 1949Nov 6, 1951Vick Chemical CompanyDevice for dispensing medicaments
US3507277 *Sep 15, 1967Apr 21, 1970Fisons Pharmaceuticals LtdInhalation device
US3518992 *Sep 13, 1967Jul 7, 1970Fisons Pharmaceuticals LtdOral inhaler with spring biased,cam driven piercing device
US3635219 *Jun 4, 1969Jan 18, 1972Fisons Pharmaceuticals LtdInhalation device
US3669113 *Jun 18, 1969Jun 13, 1972England Eunice Cockburn HowellInhalation device
SU208211A * Title not available
Referenced by
Citing PatentFiling datePublication dateApplicantTitle
US3858583 *Jan 28, 1974Jan 7, 1975Allen & Hanburys LtdMedicament inhalation device
US3870046 *Apr 22, 1974Mar 11, 1975Miles LabInsufflator
US3938516 *Jan 13, 1975Feb 17, 1976Syntex Puerto Rico, Inc.Inhalation device
US3948264 *May 21, 1975Apr 6, 1976Mead Johnson & CompanyInhalation device
US3964483 *Jan 13, 1975Jun 22, 1976Syntex Puerto Rico, Inc.Inhalation device
US3973566 *Jan 13, 1975Aug 10, 1976Syntex Puerto Rico Inc.Inhalation device
US3991761 *Oct 21, 1974Nov 16, 1976Salvatore CocozzaInhaler for powdered medicaments
US4014336 *Nov 20, 1975Mar 29, 1977Syntex Puerto Rico, Inc.Inhalation device
US4069819 *Aug 5, 1976Jan 24, 1978Societa Farmaceutici S.P.A.Inhalation device
US4095596 *Nov 26, 1976Jun 20, 1978Smithkline CorporationNasal inhaler
US4155359 *May 23, 1977May 22, 1979Antoni ZagorskiAir filtering mask
US4249526 *Apr 12, 1979Feb 10, 1981Fisons LimitedInhalation device
US4884565 *Jul 27, 1988Dec 5, 1989Miat S.P.A.Insufflator for the administration of drugs in the form of a powder pre-dosed into opercola
US5161524 *Aug 2, 1991Nov 10, 1992Glaxo Inc.Dosage inhalator with air flow velocity regulating means
US5207217 *Jun 28, 1991May 4, 1993Promo Pack SaMultiple single-dose inhaler for medicaments in powder form
US5331953 *Mar 2, 1990Jul 26, 1994Aktiebolaget DracoDevice in connection with an inhaler
US5388572 *Oct 26, 1993Feb 14, 1995Tenax Corporation (A Connecticut Corp.)Dry powder medicament inhalator having an inhalation-activated piston to aerosolize dose and deliver same
US5388573 *Dec 2, 1993Feb 14, 1995Tenax CorporationDry powder inhalator medicament carrier
US5460173 *Mar 25, 1994Oct 24, 1995Tenax CorporationDry powder inhaler medicament carrier
US5522383 *Jun 14, 1991Jun 4, 1996Rhone-Poulenc Rorer Ltd.Powder inhaler having capsule holding structure and anti-static walls
US5669378 *Dec 21, 1995Sep 23, 1997Pera; IvoInhaling device
US5676130 *Mar 18, 1996Oct 14, 1997Boehringer Ingelheim Gmbh, Inc.Separator for powdered inhalers
US5692496 *Aug 1, 1996Dec 2, 1997Innovative Devices, LlcDry powder medicament inhalator having an inhalation-activated flow diverting means for triggering delivery of medicament
US5823183 *Mar 25, 1997Oct 20, 1998Innovative DevicesDry powder medicament inhalator having an inhalation-activated flow diverting means for triggering delivery of medicament
US5988163 *May 11, 1998Nov 23, 1999Innovative DevicesDry powder medicament inhalator having an inhalation-activated flow diverting means for triggering delivery of delivery of medicament
US6048857 *Jan 20, 1998Apr 11, 2000Ellinwood, Jr.; Everett H.Trifluorobenzodiazepine
US6142146 *Jun 12, 1998Nov 7, 2000Microdose Technologies, Inc.Inhalation device
US6152130 *Jun 12, 1998Nov 28, 2000Microdose Technologies, Inc.Inhalation device with acoustic control
US6209538 *Mar 17, 1998Apr 3, 2001Robert A. CasperDry powder medicament inhalator having an inhalation-activated flow diverting means for triggering delivery of medicament
US6237591Nov 2, 1998May 29, 2001Dura Pharmaceuticals, Inc.Turbine dry powder inhaler
US6550477Jan 27, 2000Apr 22, 2003Innovative Devices, LlcDry powder medicament inhalator having an inhalation-activated flow diverting means for triggering delivery of medicament
US6561186Nov 27, 2001May 13, 2003Innovative DevicesDry powder medicament inhalator having an inhalation-activated flow diverting means for triggering delivery of medicament
US6672304Mar 24, 2000Jan 6, 2004Innovative Devices, LlcInhalation actuated device for use with metered dose inhalers (MDIs)
US6729324Feb 11, 2002May 4, 2004Innovative Devices, Llc.Inhalation actuated device for use with metered dose inhalers (MDIs)
US6792945 *Dec 13, 2001Sep 21, 2004Glaxo Group LimitedHandles large number of discrete unit powder doses in blister packs; small size
US6948494May 10, 2000Sep 27, 2005Innovative Devices, Llc.improved entrainment/deep deposition into lungs; for treatment of asthma
US7040316 *Mar 3, 2004May 9, 2006Becton, Dickinson And CompanyMedicament inhalation delivery devices and methods for using the same
US7080644Jun 25, 2001Jul 25, 2006Microdose Technologies, Inc.Packaging and delivery of pharmaceuticals and drugs
US7225808Jul 14, 2004Jun 5, 2007Glaxo Group LimitedInhalation device
US7270127Sep 3, 2002Sep 18, 2007Becton, Dickinson And CompanyMedicament respiratory delivery device
US7284553Dec 4, 2003Oct 23, 2007Boehringer Ingelheim Pharma Gmbh & Co. KgPowder inhaler comprising a chamber for a capsule for taking up a non-returnable capsule being filled with an active ingredient
US7318434Feb 17, 2005Jan 15, 2008Microdose Technologies, Inc.Synthetic jet based medicament delivery method and apparatus
US7318436Oct 25, 2004Jan 15, 2008Innovative Devices, LlcMedicament container with same side airflow inlet and outlet and method of use
US7334577Mar 1, 2006Feb 26, 2008Microdose Technologies, Inc.Synthetic jet based medicament delivery method and apparatus
US7389775Feb 7, 2005Jun 24, 2008Glaxo Group LimitedInhalation device
US7779837Dec 6, 2007Aug 24, 2010Microdose Therapeutx, Inc.Synthetic jet based medicament delivery method and apparatus
US7810495Jun 19, 2006Oct 12, 2010Microdose Therapeutx, Inc.Packaging and delivery of pharmaceuticals and drugs
US7870856Apr 10, 2007Jan 18, 2011Boehringer Ingelheim International GmbhInhaler
US7950390Aug 25, 2009May 31, 2011Microdose Therapeutx, Inc.Packaging and delivery of pharmaceuticals and drugs
US8006695Nov 10, 2005Aug 30, 2011Cipla LimitedInhaler
US8298575Jan 8, 2008Oct 30, 2012Boehringer Ingelheim Pharma Gmbh & Co. Kgconsist of water-insoluble hydrophobic synthetic materials which do not significantly affect the pharmaceutical quality of the contents themselves, but improve usability of filled capsules with regard to function, longevity, and/or the geographic location of their use
US8322338May 7, 2010Dec 4, 2012Microdose Therapeutx, Inc.Synthetic jet based medicament delivery method and apparatus
US8357696Jan 28, 2010Jan 22, 2013Mpex Pharmaceuticals, Inc.Aerosolized fluoroquinolones and uses thereof
US8371294Feb 25, 2009Feb 12, 2013Microdose Therapeutx, Inc.Method and apparatus for driving a transducer of an inhalation device
US8397717Oct 20, 2006Mar 19, 2013Boehringer Ingelheim International GmbhInhaler with mouthpiece having a microbiological protective function
US8439033Oct 6, 2008May 14, 2013Microdose Therapeutx, Inc.Inhalation device
US8474452Feb 23, 2005Jul 2, 2013Microdose Therapeutx, Inc.Directional flow sensor inhaler
US8522775 *Jun 15, 2007Sep 3, 2013Cipla LimitedDry powder inhaler
US8524734Oct 22, 2009Sep 3, 2013Mpex Pharmaceuticals, Inc.Aerosolized fluoroquinolones and uses thereof
US8524735Oct 22, 2009Sep 3, 2013Mpex Pharmaceuticals, Inc.Aerosolized fluoroquinolones and uses thereof
US8546423Oct 22, 2009Oct 1, 2013Mpex Pharmaceuticals, Inc.Aerosolized fluoroquinolones and uses thereof
US8561609Dec 7, 2011Oct 22, 2013Respira Therapeutics, Inc.Dry powder inhaler
US8573202Aug 17, 2010Nov 5, 2013Microdose Therapeutx, Inc.Packaging and delivery of pharmaceuticals and drugs
US8629139Oct 6, 2009Jan 14, 2014Mpex Pharmaceuticals, Inc.Topical use of Levofloxacin for reducing lung inflammation
US8651104May 11, 2012Feb 18, 2014Respira Therapeutics, Inc.Bead-containing dry powder inhaler
US8662076Jan 6, 2006Mar 4, 2014Boehringer Ingelheim Pharma Gmbh & Co. KgTwo-part capsule with pre-closure for housing pharmaceutical preparations for powder inhalers
US8748488Mar 14, 2013Jun 10, 2014Microdose Therapeutx, Inc.Methods and compositions for administration of oxybutynin
US8763606May 21, 2010Jul 1, 2014Microdose Therapeutx, Inc.Rotary cassette system for dry powder inhaler
US8815838Oct 6, 2009Aug 26, 2014David C. GriffithAerosol fluoroquinolone formulations for improved pharmacokinetics
US20090320838 *Jun 15, 2007Dec 31, 2009Cipla LimitedDry powder inhaler
CN101815552BJul 31, 2008Mar 6, 2013贝林格尔.英格海姆国际有限公司吸入器
EP0041783A1 *May 18, 1981Dec 16, 1981FISONS plcInhalation device for powdered medicaments
EP1204437A1 *Jun 12, 2000May 15, 2002Thayer Medical CorporationCollapsible, disposable mdi spacer and method
EP1941868A2Feb 26, 2001Jul 9, 2008PharmaKodex LimitedImprovements in or relating to the delivery of oral drugs
EP2020249A1 *Aug 1, 2007Feb 4, 2009Boehringer Ingelheim Pharma GmbH & Co. KGInhalator
EP2357015A2Apr 4, 2007Aug 17, 2011MicroDose Therapeutx, Inc.Variable dose inhalation device
EP2594272A2May 18, 2006May 22, 2013Mpex Pharmaceuticals, Inc.Aerosolized fluoroquinolones and uses thereof
WO1999064095A2Jun 14, 1999Dec 16, 1999Microdose Technologies IncMetering, packaging and delivery of pharmaceuticals and drugs
WO2001062342A1 *Feb 23, 2001Aug 30, 2001Irm Technologies Pty LtdNasal filter and sampler
WO2005081833A2Feb 17, 2005Sep 9, 2005Microdose Technologies IncSynthetic jet based medicament delivery method and apparatus
WO2006051300A1 *Nov 10, 2005May 18, 2006Cipla LtdInhaler
WO2007107160A1Mar 21, 2007Sep 27, 2007Bang & Olufsen Medicom AsInhaler flow channel
WO2009016238A2 *Jul 31, 2008Feb 5, 2009Boehringer Ingelhelheim InternInhaler
WO2009139732A1 *May 15, 2009Nov 19, 2009Bilgic MahmutDry powder inhaler
Classifications
U.S. Classification128/203.15
International ClassificationA61M, A61M15/00, A61J7/00, A61M13/00
Cooperative ClassificationA61M2015/0033, A61M15/0028, A61M2202/064
European ClassificationA61M15/00C