|Publication number||US3811426 A|
|Publication date||May 21, 1974|
|Filing date||May 21, 1973|
|Priority date||May 21, 1973|
|Publication number||US 3811426 A, US 3811426A, US-A-3811426, US3811426 A, US3811426A|
|Inventors||Culver G, Riemath W|
|Original Assignee||Atomic Energy Commission|
|Export Citation||BiBTeX, EndNote, RefMan|
|Patent Citations (6), Referenced by (107), Classifications (7)|
|External Links: USPTO, USPTO Assignment, Espacenet|
United States Patent [191 Culver et al.
[ METHOD AND APPARATUS FOR THE lN-VESSEL RADIATION TREATMENT OF BLOOD  Inventors: Gordon G. Culver, Klamath Falls, Oreg.; William F. Riemath, Pasco, Wash.
 Assignee: The United States of America as represented by the United States Atomic Energy Commission, Washington, DC.
 Filed: May 21, 1973  Appl. No.: 362,613
 U.S. Cl. ..-128/l.2, 250/493  Int. Cl A6ln 5/10  Field of Search l28/l.l, 1.2, 2 A, 260,
[5 6] References Cited UNITED STATES PATENTS 1,823,239 9/1931 Cervi 128/12 1,954,868 4/1934 Failla et al. 128/12 2,153,889 4/1939 Hames l28/1.l 2,405,026 7/1946 Feoer et a1 250/493 2,546,759 3/1951 Lee et al 128/260 3,505,991 4/1970 Hellerstein et al l28/l.l
[111 3,811,426 [451 May21, 1974 Primary Examiner-William E. Kamm Attorney, Agent, or Firm-John A. Horan; Arthur A. Churm; Robert J. Fisher 5 7] ABSTRACT An apparatus and a corresponding method for the invivo radio-therapy of blood by irradiation of the blood within the blood vessel. The device includes a wire which has a straight section and small oppositely facing loops at each of its two ends. An active radioisotope-layer is deposited over the center portion of the straight section of the wire and this radioisotopelayer is sealingly covered with a coating-layer to prevent any leaking of the radioisotope into the blood. The wire is adapted for surgical implantation diagonally transverse a blood vessel in a manner so that the active radioisotope-layer lies fullywithin the blood vessel, while the end of the wire projects such that the two loops lie fully exterior to the blood vessel. Following the depositing of the radioisotope-layer and the coating-layer on the wire and sterilization of the wire, the device is surgically implanted diagonally transverse the blood vessel and is anchored in place with respect to the blood vessel by suturing through the loops.
7 Claims, 1 Drawing Figure METHOD AND APPARATUS FOR THE IN-VESSEL RADIATION TREATMENT OF BLOOD CONTRACTUAL ORIGIN OF THE INVENTION The invention described herein was made in the course of, or under, a contact with the UNITED STATES ATOMIC ENERGY COMMISSION.
BACKGROUND OF THE INVENTION The present invention relates to radiotherapy and radiation treatment of blood and is particularly concerned with the in-vivo radiation treatment of blood. Specifically, the present invention is concerned with the radiation treatment of blood within the blood vessel. Still more particularly, the present invention relates to a method and a device for implantating a radiation source within the blood vessel which reduces the amount of shielding required and hence the complexity of the device and simplifies surgical procedure.
Radiotherapy including radiation treatment of blood as a potential cure or control of various diseases is well known in the art, radiotherapy being extensively used in the treatment of various forms of cancer. In particular, radiotherapy as a treatment for the control of leukemia has been studied and undertaken in the past.
Suppression oflymphocyte levels in circulating blood following irradiation of the total body with low doses of ionizing radiation is well known. It has been demonstrated that irradiation of blood in an exterior loop (extracorporeal irradiation of blood) suppresses lymphocyte levels without damage to other body tissues. It has consequently been shown that extracorporeal irradiation of blood is an effective adjunct or alternative to drug therapy for treating some forms of leukemia.
Immune reactions initiated by lymphocytes are usually the ultimate reason for failure oforgan transplants. Current methods of suppressing these immune reactions include use of drug therapy, antilymphocyte antibodies, and irradiation. Typically, more than one of these approaches is used since there are problems associated with each.
Acceptance times of skin allografts have been extended by extracorporeal irradiation of blood and this technique has been evaluated for its applicability for immunosuppression-relative to renal allografts. Significant reduction in early rejection eposodes and a significantly higher frequency of six-month renal graft survival has been reported for extracorporeal irradiation of blood-treated groups.
Most treatments of both experimental animals and humans have been accomplished by shunting blood through large fixed equipment such as cobalt-60, cesium- I 37 or X-ray sources, thereby necessitating specialized facilities. With the relatively long treatment regimes required, this severely limits the numbers of patients who can receive treatment and requires the inconvenience and expense of hospitalization. A small, inexpensive. portable irradiator is needed for the above reasons and also to permit chronic exposures of patients prior to and subsequent to kidney transplants.
A small implantable irradiator which would permit direct in-vivo irradiation of the blood is also desirable. One such portable irradiator consists of a small tube of shielding material coated on the inside with a radioactive isotope which is further coated to prevent leakage into the blood system. Small sections of an artery or vein are surgically removed and this tube inserted in substitution therefor, the insertion being accomplished by suturing the blood vessel to small fiber tubes located on each end of the device. These devices then serve as a small section of the blood vessel.
Alternatives to these devices are desirable as the surgical procedures involved in inserting them as a substitution for a section of a blood vessel are complex arid these devices require shielding to prevent the undesirable radiation of surrounding tissues.
Therefore, it is an object of the present invention to provide a methodand an apparatus for radiotherapy of blood.
It is a'further object of the present invention to provide a method and apparatus for in-vivo irradiation of blood. I
An additional object of the present invention is to provide a method and apparatus for the irradiation treatment of blood within'the blood vessel itself.
Another object of the present invention is to provide a device which is less complex and requires less or no shielding and which can be implanted by simplified surgical procedures. I 7
Other objects and advantages of the present invention will become apparent upon readingthe following description and with particular reference to the specific embodiment described hereinbelow.
' and apparatus is provided for in-vivo radiotherapy of blood by irradiation of the blood within a blood vessel.
A layer from an active radioisotope is deposited on the center portion of a wire which includes a straight section and small oppositely facing loops at each of its two ends. A coating-layer is deposited over the active radioisotope-layer to sealingly cover the radioisotope and prevent leaking of the radioisotope into the blood. Following sterilization of the device, the device is implanted in a blood vessel by surgically inserting the wire diagonally transverse a blood vessel in a manner such that the active layer lies fully within the blood vessel while the ends project such that the two loops lie fully exterior to the blood vessel. The device is anchored in place with respect to the blood vessel by suturing to the blood vessel through the loops at the end of the wire.
BRIEF DESCRIPTION OF THE DRAWINGS' An understanding of the features and operation of the present invention can be obtained from a reading of the following description and with reference to the drawing which is a sectional view through a blood vessel showing the device partially in section implanted in accordance with the present invention.
DETAILED DESCRIPTION OF THE INVENTION Referring now to the drawing, there is shown a device in accordance with the-present invention implanted layer 18. A coating-layer coats the central portion of the straight section 12 and sealingly covers the radioisotope-layer 18 so as to prevent any leaking of the radioisotope from the device into the bloodstream.
The device is shown as implanted in a blood vessel 22. The device is adapted for implantation diagonally transverse blood vessel 22 and is implanted in a manner such that active layer 18 lies fully within blood vessel 22, i.e., active layer 18 lies within the interior 24 of the blood vessel 22 between the walls thereof. The device is further implanted such that the loops l4 and 16 at the two ends of the straight section 12 lie fully outside and exterior to the blood vessel 22. The device is anchored in place with respect to the blood vessel such as by sutures 26 and 28 through loops l4 and 16, respectively. The device is anchored in order to prevent the undesirable loss of the device in the body and to prevent undesirable movement relative to the blood vessel 22. i The active radioisotope-layer 18 can be deposited on the center portion of the wire in any manner known and practicedin the art including, amo'ngothers, elec-- troplating from a solution containing the radioisotope. Similarly, the coating-layer can be deposited over the active radioisotope-layer in various manners well known in the art including, among others, vacuum sputtering of a metal. Following depositing of the coating-layer and prior to implantation, the device must be sterilized, sterilization by gamma irradiation being one of the many possible methods which can be employed, The device is then implanted in a blood vessel by surgically inserting the device so as to lie diagonally transverse the blood vessel, as described hereinabove. While various means of surgical implantation can be used, two examples of surgical methods which have been found particularly adaptable to the present device are insertion through the blood vessel in a hypodermic needle followed by withdrawal of the hypodermic needle,
' leaving the device in place, and insertion of the device across theblood vessel through two surgical incisions in the wall of the blood vessel, the incisions being made on opposite sides of the blood vessel and diagonally spaced so as to accommodate the device diagonally thereacross. lf the'device is implanted by the latter method wherein incisions are made in the blood vessel wall, the sutures used to close the surgical incisions in the blood vessel can also be employed to anchor the device in place with respect to the blood vessel by making the sutures through the loops on the respective two ends of the straight section.
This device offers versatility in that the choice of the radioisotope to be used can be made based upon the desired intensity of radiation and the desired energy of radiation. Since the coating-layer can be made very thin as by vacuum sputtering a metal, it is possible to use either alpha emitters or beta emitters for the radioisotope. Since the device is inserted directly into the bloodstream and is surrounded by blood, extensive radiation shielding is not required, as the radiation emitted will be absorbed by the blood itself with no damage to surrounding tissues. This device permits surgical implantation by means of much simpler surgical procedures and is therefore far less traumatic than other known implantation procedures.
DESCRIPTION OF PARTICULAR EMBODIMENT While the invention is hereinafter described in connection with a particular specific embodiment, it will be understood that it is not intended to limit the invention to only that specific embodiment, but it is intended to cover all alternatives, modifications and equivalents as maybe included within the spirit and scope of the inventionas defined by the appended claims.
A device was constructed and implanted in accordance with the present invention. The device was formed of a Type 302 stainless steel spring wire 0.010 inch in diameter and just over 2 inches long. The wire was formed with opposing 0.040-inch-diameter loops at each end, the centers of the loops being 2 inches apart.
The wire was ultrasonically'cleaned in approximately 10 percent solution of Delex a commercial detergent and ultrasonically rinsed in distilled water twice, followed by a tripple rinse in reagent-grade acetone, and I used in the past for production of standard samples of,
other radioactive actinides,
The electroplating cell was filled with approximately 10 cc of dimethyl sulfoxide. A D-C power supply. was
connected to a platinum anode and the irradiator wire serving as a cathode with small alligator clips. A magnetic stirrer was adjusted to rotate the stirring bar such as to give good mixing without causing a noticeable vortex in the liquid. micrograms of dried "PuO was dissolved in 25 microliters of 6 N nitric acid and transferred to the cell. The power supply was adjusted so as to apply 3.5 volts across the cell and adjusted so that the current flow through the cell was 0. l milliamp. The current was applied and continued for 20 minutes. in order to prevent redissolution of some of the PuO,, the liquid was decanted with a syringe to below the level of the wire before reducing the voltage.
While the current, voltage and electrode spacing are probably not critical and are interdependent as in any cell, in order toobtain very smooth deposits, itis important to adjust the current flow and stirring speed to prevent the formation of bubbles on the wire. 0n previous attempts using higher voltage and current, a few bubbles were produced on the wire, resulting in deposits which appeared thicker to the naked eye and were black. On microscopic examination, these deposits were found to be rough with high peaks and with the appearance of a sponge. On such a deposit, a containment layer thick enough to assure a nonsmearable de- M time, the alpha radiation level from the wire was mea-' sured using a yellow face Juno" and a reading of approximately 60 rads per hour uncorrected as read on the Juno was obtained.
Sputter deposition of each coating or containment layer was done in two steps in a MRC Model 8620 RF sputtering systemlocated in a glove box. The'active wire was mounted on a simple holding fixture consisting of two support wires silver-brazed to a 5-inch stainless steel disk and bent to support the wires l/4 inch above the disk. It was necessary to open the chamber and to turn the wire over to sputter the containment on the reverse side. The chamber was evacuated to 3 X Torr before back-filling to 4.5 millitorr of argon. The first platinum containment layer of approximately 7,500 A was sputter-deposited at a power of 250 watts on a S-inch-diameter target, zero bias, 800 volts RF peak to peak. The 7,500 A estimate is based on deposition rates for platinum previously established at 3.22 microns per hour at 500 watts by metallographic techniques. The chamber was vented to argon, opened, the wire turned over, and pumped down and platinum sputtered on the other side. 7
After the first complete containment layer had been sputtered on, the wire was removed to an open-faced hood and smearability and activity checked. After a light rub on the wire, a Q-tip counted 200-300 disintegrations per minute. Alpha activity on the yellow face Juno had dropped to 25 rads per hour uncorrected. The wire was then carefully rubbed with tweezer tips which had been wrapped with optical lens paper in order to knock off any high peaks of plutonium oxide.
The wire was then placed back in a sputtering chamber and approximately 3,500 A of platinum was deposited using the same sputtering conditions as for the first containment layer. After sputtering, the wire was smeared with Q-tips and facial tissue and only background count was noted, which is less than 25 disintegrations per minute. The alpha activity as read on the yellow face .luno was 12.5 rads per hour on one side and rads per hour on the other side.
An alpha-energy analysis was run on the completed device. using a 400-channel alpha-energy analyzer. The results showed the absence of any alphas having the 5.5 MeV energy characteristic of Pu which was convincing evidence that the activity is contained until such time that the platinum containment is either damaged through handling or eroded away by the blood flow. A peak was located at about 4.82 MeV and calculation of the thickness ofthe containment layer based on the energy analysis indicated a thickness in reasonable agreement with that projected from the deposition rate data.
Following sterilization with 400,000 rads of gamma radiation, the device was implanted in a beagle dog. In the present case. insertion was accomplished, while the dog was anesthetized as for any surgery, by passing a long steel needle obliquely through the artery and drawing the irradiator device through the needle by means of a suture thread and suturing. through the loops of the device at both ends, to the wall of the blood vessel following removal of the steel needle. With this technique. there is little disturbance of the blood vessel. Radiographs taken subsequent to implantation showed thewire continuing in place. The other surgical procedure contemplated for use with the present device will be to dissect. the descending aorta, make two small slits on opposite sides of the blood vessel and 2 inches diagonally apart, insert the wire and anchor it with sutures also used to close the slits. This procedure is much simplified over the previously used method of removing a part of the aorta and suturing in its place a multilayered tube with woven fiber ends.
Two of the devices were implanted in dogs. The first device was nonradioactive and'was implanted to develop techniques and to check thrombic effects of the wire itself. The device with the radioactive layer was subsequently imp'lanted. After days, there was no gross evidence of thrombic effect in either animal but total absence of clotting can be confirmed only after the animal is sacrificed. While Pu was used as the source in the present instance, it is possible that because of the very short range of alpha particles and the difficulty of detecting any leakage, should a leakage subsequently develop, it is possible that beta emitters will prove to be preferable as the active radioisotope. A beta emitter would provide a radiation which is suffi' ciently penetrating to give a sufficiently high dose rate to the blood and yet is not so penetrating that it would be damaging to surrounding tissue. Use of more penetrating beta radiation would also have the advantage that a thicker containment layer could be used, insuring its integrity and containment of the radioisotope without reducing the radiation level to unacceptably low values. 1
The embodiments of the invention in which an exclusive property or privilege is claimed'are defined as follows:
1. An in-vivo radioisotope blood irradiator for invessel radiation treatment of blood comprising: a wire including a straight section and a small oppositely facing loop at each of the two ends thereof; an active radioisotope-layer deposited over the center portion of said straight section of the wire; and a coating-layer sealingly covering said active radioisotope-layer; said wire adapted for implantation diagonally transverse a blood vessel in a manner so that said active layer lies fully within said vessel and said ends project such that said two loops lie fully exterior to said vessel.
2. The blood irradiator of claim 1 further comprising suture means associated with each of said loops for anchoring said wire with respect to said blood vessel.
3. The blood irradiator of claim 1 wherein said wire is stainless steel spring wire about 0.01 inch in diameter and slightly in excess of 2 inches in length, said loops are about 0.04 inch in diameter, the centers of said two loops are about 2 inches apart, and the active radioisotope-layer is deposited over the center 1 inch of said wire.
4. The blood irradiator of claim 3 wherein said active 4 radioisotope-layer comprises PuO and said coatinglayer comprises platinum.
5. A method for in-vivo radiotherapy of blood by irradiation of the blood within a blood vessel comprising:
a. depositing a layer of an active radioisotope on the center portion of a wire which includes a straight section and a small oppositely facing loop at each of the two ends thereof;
b. depositing a coating-layer over said active radioisotope-layer so as to sealingly cover said radioisotope;
c. sterilizing said wire; and
d. implanting said wire in said blood vessel by surgically inserting the wire diagonally transverse said blood vessel in a manner so that said active layer lies fully within said vessel and said ends project 3,81 1,426 7 8 such that said two loops lie fully exterior to said is deposited on the center portion of 21 Stainless steel vessel s wire by electroplating from a solution containing 6. The method of claim further comprising: suturmpuo and a thinvcoafin- 4a er of lafinum is de os ing through said loops to anchors'aid wire with respect 2 g Y P P to id bl d vesseL 5 ited over said PuO by vacuum sputtering.
7. The method of claim 5 wherein a layer of "F'u0
|Cited Patent||Filing date||Publication date||Applicant||Title|
|US1823239 *||Jan 16, 1926||Sep 15, 1931||Radium Emanation Corp||Emanation seed|
|US1954868 *||Dec 18, 1929||Apr 17, 1934||Ernest Rose John||Method and means for treatment by radiations|
|US2153889 *||Jul 20, 1937||Apr 11, 1939||J A Deknatel & Son Inc||Suture|
|US2405026 *||Dec 14, 1943||Jul 30, 1946||Canadian Radium & Uranium Corp||Alpha-ray emission device and method of making the same|
|US2546759 *||Dec 15, 1945||Mar 27, 1951||Alexander William M||Subcutaneous medication|
|US3505991 *||Feb 13, 1968||Apr 14, 1970||Us Air Force||Intracorporeal vascular prosthetic blood irradiator|
|Citing Patent||Filing date||Publication date||Applicant||Title|
|US3927325 *||Jul 10, 1974||Dec 16, 1975||Us Energy||Tissue irradiator|
|US4976680 *||Oct 7, 1988||Dec 11, 1990||Hayman Michael H||Apparatus for in situ radiotherapy|
|US5030195 *||Jun 5, 1989||Jul 9, 1991||Nardi George L||Radioactive seed patch for prophylactic therapy|
|US5059166 *||Dec 11, 1989||Oct 22, 1991||Medical Innovative Technologies R & D Limited Partnership||Intra-arterial stent with the capability to inhibit intimal hyperplasia|
|US5503613 *||Jan 21, 1994||Apr 2, 1996||The Trustees Of Columbia University In The City Of New York||Apparatus and method to reduce restenosis after arterial intervention|
|US5683345 *||Oct 27, 1994||Nov 4, 1997||Novoste Corporation||Method and apparatus for treating a desired area in the vascular system of a patient|
|US5707332 *||Nov 30, 1995||Jan 13, 1998||The Trustees Of Columbia University In The City Of New York||Apparatus and method to reduce restenosis after arterial intervention|
|US5713828 *||Nov 27, 1995||Feb 3, 1998||International Brachytherapy S.A||Hollow-tube brachytherapy device|
|US5728042 *||Dec 29, 1995||Mar 17, 1998||Schneider (Europe) A.G.||Medical appliance for ionizing radiation treatment having radiopaque markers|
|US5840008 *||Nov 13, 1995||Nov 24, 1998||Localmed, Inc.||Radiation emitting sleeve catheter and methods|
|US5863284 *||Aug 20, 1996||Jan 26, 1999||Localmed, Inc.||Devices and methods for radiation treatment of an internal body organ|
|US5882290 *||Feb 29, 1996||Mar 16, 1999||Scimed Life Systems, Inc.||Intravascular radiation delivery system|
|US5899882 *||Apr 4, 1996||May 4, 1999||Novoste Corporation||Catheter apparatus for radiation treatment of a desired area in the vascular system of a patient|
|US6019718 *||May 30, 1997||Feb 1, 2000||Scimed Life Systems, Inc.||Apparatus for intravascular radioactive treatment|
|US6045495 *||Jul 25, 1996||Apr 4, 2000||The Trustees Fo Columbia University In The City Of New York||Apparatus and method to treat a disease process in a luminal structure|
|US6059713 *||Mar 5, 1998||May 9, 2000||Scimed Life Systems, Inc.||Catheter system having tubular radiation source with movable guide wire|
|US6059812 *||Mar 6, 1998||May 9, 2000||Schneider (Usa) Inc.||Self-expanding medical device for centering radioactive treatment sources in body vessels|
|US6071227 *||Jan 27, 1997||Jun 6, 2000||Schneider (Europe) A.G.||Medical appliances for the treatment of blood vessels by means of ionizing radiation|
|US6074338 *||Jun 28, 1994||Jun 13, 2000||Schneider (Europe) A.G.||Medical appliances for the treatment of blood vessels by means of ionizing radiation|
|US6086942 *||May 27, 1998||Jul 11, 2000||International Brachytherapy S.A.||Fluid-jet deposition of radioactive material for brachytherapy devices|
|US6099454 *||Mar 6, 1997||Aug 8, 2000||Scimed Life Systems, Inc.||Perfusion balloon and radioactive wire delivery system|
|US6110097 *||Mar 6, 1997||Aug 29, 2000||Scimed Life Systems, Inc.||Perfusion balloon catheter with radioactive source|
|US6117065 *||Jun 24, 1998||Sep 12, 2000||Scimed Life Systems, Inc.||Perfusion balloon catheter with radioactive source|
|US6120533 *||Nov 13, 1998||Sep 19, 2000||Isostent, Inc.||Stent delivery system for a radioisotope stent|
|US6146322 *||Oct 30, 1996||Nov 14, 2000||Schneider (Europe) Ag||Irradiating filament and method of making same|
|US6163947 *||Jul 31, 1997||Dec 26, 2000||International Brachytherapy S.A.||Method of making a hollow-tube brachytherapy device|
|US6175760 *||Feb 17, 1998||Jan 16, 2001||University Of Iowa Research Foundation||Lesion localizer for nuclear medicine|
|US6203485||Oct 7, 1999||Mar 20, 2001||Scimed Life Systems, Inc.||Low attenuation guide wire for intravascular radiation delivery|
|US6217503||Sep 26, 1996||Apr 17, 2001||The Trustees Of Columbia University In The City Of New York||Apparatus and method to treat a disease process in a luminal structure|
|US6231494||Nov 17, 1997||May 15, 2001||Schneider (Europe) A.G.||Medical device with radiation source|
|US6234951||Jan 10, 1997||May 22, 2001||Scimed Life Systems, Inc.||Intravascular radiation delivery system|
|US6254552 *||Oct 1, 1998||Jul 3, 2001||E.I. Du Pont De Nemours And Company||Intra-coronary radiation devices containing Ce-144 or Ru-106|
|US6258019||Sep 8, 1999||Jul 10, 2001||Scimed Life Systems, Inc.||Catheter for intraluminal treatment of a vessel segment with ionizing radiation|
|US6264596||Nov 3, 1997||Jul 24, 2001||Meadox Medicals, Inc.||In-situ radioactive medical device|
|US6264599 *||Aug 10, 1999||Jul 24, 2001||Syntheon, Llc||Radioactive therapeutic seeds having fixation structure|
|US6267775||Mar 6, 2000||Jul 31, 2001||Schneider (Usa) Inc.||Self-expanding medical device for centering radioactive treatment sources in body vessels|
|US6302865||Mar 13, 2000||Oct 16, 2001||Scimed Life Systems, Inc.||Intravascular guidewire with perfusion lumen|
|US6306074||May 4, 1999||Oct 23, 2001||Novoste Corporation||Method and apparatus for radiation treatment of a desired area in the vascular system of a patient|
|US6347443||Dec 22, 2000||Feb 19, 2002||International Brachytherapy S.A.||Method of making a hollow-tube precursor brachytherapy device|
|US6352501||Sep 23, 1999||Mar 5, 2002||Scimed Life Systems, Inc.||Adjustable radiation source|
|US6398708||Oct 28, 1998||Jun 4, 2002||Scimed Life Systems, Inc.||Perfusion balloon and radioactive wire delivery system|
|US6398709||Oct 19, 1999||Jun 4, 2002||Scimed Life Systems, Inc.||Elongated member for intravascular delivery of radiation|
|US6413203||Sep 16, 1998||Jul 2, 2002||Scimed Life Systems, Inc.||Method and apparatus for positioning radioactive fluids within a body lumen|
|US6416457||Mar 9, 2000||Jul 9, 2002||Scimed Life Systems, Inc.||System and method for intravascular ionizing tandem radiation therapy|
|US6422989||Nov 5, 1999||Jul 23, 2002||Scimed Life Systems, Inc.||Method for intravascular radioactive treatment|
|US6461433||Jul 5, 2000||Oct 8, 2002||International Brachytherapy, S.A.||Fluid-jet deposition of radioactive material|
|US6475644||Aug 31, 1999||Nov 5, 2002||Radiovascular Systems, L.L.C.||Radioactive coating solutions methods, and substrates|
|US6514191||Jan 25, 2000||Feb 4, 2003||Schneider (Europe) A.G.||Medical appliances for the treatment of blood vessels by means of ionizing radiation|
|US6551278 *||Nov 10, 2000||Apr 22, 2003||Scimed Life Systems, Inc.||Miniature x-ray catheter with retractable needles or suction means for positioning at a desired site|
|US6582352||Jan 2, 2001||Jun 24, 2003||Schneider (Europe) A.G.||Medical appliance for treatment by ionizing radiation|
|US6582353||Jul 18, 2000||Jun 24, 2003||Scimed Life Systems, Inc.||Intravascular radiation delivery system|
|US6599230||Mar 14, 2001||Jul 29, 2003||Scimed Life Systems, Inc.||Intravascular radiation delivery system|
|US6616629||Jun 14, 1999||Sep 9, 2003||Schneider (Europe) A.G.||Medical appliance with centering balloon|
|US6638205||Nov 17, 2000||Oct 28, 2003||Mds (Canada) Inc.||Radioactive medical device for radiation therapy|
|US6652441||Apr 17, 2001||Nov 25, 2003||The Trustees Of Columbia University In The City Of New York||Apparatus and method to treat a disease process in a luminal structure|
|US6676590||Dec 8, 1997||Jan 13, 2004||Scimed Life Systems, Inc.||Catheter system having tubular radiation source|
|US6706014||Feb 14, 2003||Mar 16, 2004||Scimed Life Systems, Inc.||Miniature x-ray unit|
|US6752752||Feb 14, 2003||Jun 22, 2004||Scimed Life Systems, Inc.||Multi-source x-ray catheter|
|US6910999||Feb 6, 2003||Jun 28, 2005||Scimed Life Systems, Inc.||Miniature x-ray unit|
|US6999559||Feb 14, 2003||Feb 14, 2006||Scimed Life Systems, Inc.||Heat sink for miniature x-ray unit|
|US7066872||Apr 11, 2003||Jun 27, 2006||Best Vascular, Inc.||Method and apparatus for treating a desired area in the vascular system of a patient|
|US7074291||Jun 4, 2002||Jul 11, 2006||Worldwide Medical Technologies, L.L.C.||Delivery system and method for interstitial radiation therapy using strands constructed with extruded strand housings|
|US7083567 *||Feb 10, 2004||Aug 1, 2006||Michel E. Mawad||Retrievable, shielded radiotherapy implant|
|US7094198||Jun 4, 2002||Aug 22, 2006||Worldwide Medical Technologies, Llc||Delivery system and method for interstitial radiation therapy using seed elements with ends having one of projections and indentations|
|US7160238||Dec 21, 1999||Jan 9, 2007||Best Vascular, Inc.||Method and apparatus for treating a desired area in the vascular system of a patient|
|US7211039||Apr 24, 2006||May 1, 2007||Worldwide Medical Technologies Llc||Strand with end plug|
|US7407477||Mar 27, 2007||Aug 5, 2008||Worldwide Medical Technologies Llc||Strand with end plug|
|US7736293||Jul 22, 2005||Jun 15, 2010||Biocompatibles Uk Limited||Implants for use in brachytherapy and other radiation therapy that resist migration and rotation|
|US7736294||Oct 28, 2005||Jun 15, 2010||Biocompatibles Uk Limited||Delivery system and method for interstitial radiation therapy using seed strands with custom end spacing|
|US7736295||Nov 15, 2005||Jun 15, 2010||Biocompatibles Uk Limited||Delivery system and method for interstitial radiation therapy using custom end spacing|
|US7778701 *||Nov 17, 2005||Aug 17, 2010||Cordia Corporation||Proton generating catheters and methods for their use in enhancing fluid flow through a vascular site occupied by a calcified vascular occlusion|
|US7874974||Oct 28, 2005||Jan 25, 2011||Biocompatibles Uk Limited||Delivery system and method for interstitial radiation therapy|
|US7874976||Sep 7, 2006||Jan 25, 2011||Biocompatibles Uk Limited||Echogenic strands and spacers therein|
|US7878964||Sep 7, 2006||Feb 1, 2011||Biocompatibles Uk Limited||Echogenic spacers and strands|
|US7901345||Jul 1, 2010||Mar 8, 2011||Boston Scientific Scimed, Inc||Miniature X-ray unit|
|US7942803||Jan 21, 2010||May 17, 2011||Biocompatibles Uk Limited||Delivery system and method for interstitial radiation therapy|
|US7972261||Jul 20, 2006||Jul 5, 2011||Biocompatibles Uk Limited||Devices to resist migration and rotation of implants used in brachytherapy and other radiation therapy|
|US7985172||Apr 27, 2007||Jul 26, 2011||Biocompatibles Uk Limited||After-loader devices and kits|
|US7988611||Nov 3, 2006||Aug 2, 2011||Biocompatibles Uk Limited||After-loader for positioning implants for needle delivery in brachytherapy and other radiation therapy|
|US8021291||Jan 21, 2009||Sep 20, 2011||Biocompatibles Uk Limited||Markers for use in brachytherapy and other radiation therapy that resist migration and rotation|
|US8066627||Jun 16, 2006||Nov 29, 2011||Biocompatibles Uk Limited||Delivery system and method for interstitial radiation therapy using strands constructed with extruded strand housings|
|US8114007||Dec 15, 2008||Feb 14, 2012||Biocompatibles Uk Limited||Implants for use in brachytherapy and other radiation therapy that resist migration and rotation|
|US8187159||Feb 26, 2009||May 29, 2012||Biocompatibles, UK||Therapeutic member including a rail used in brachytherapy and other radiation therapy|
|US8192345||Jan 21, 2009||Jun 5, 2012||Biocompatibles, UK||Cartridge for use with brachytherapy applicator|
|US8470294||Jun 25, 2010||Jun 25, 2013||Microspherix Llc||Flexible and/or elastic brachytherapy seed or strand|
|US8790235||Aug 7, 2009||Jul 29, 2014||Eckert & Ziegler Debig S.A.||Devices to resist migration and rotation of implants used in brachytherapy and other radiation therapy|
|US8795146||May 4, 2010||Aug 5, 2014||Eckert & Ziegler Bebig S.A.||Implants including spacers for use in brachytherapy and other radiation therapy that resist migration and rotation|
|US8821835||Jun 13, 2013||Sep 2, 2014||Microspherix Llc||Flexible and/or elastic brachytherapy seed or strand|
|US20030084988 *||Jun 4, 2002||May 8, 2003||Terwilliger Richard A.||Delivery system and method for interstitial radiation therapy using strands constructed with extruded strand housings|
|US20030092958 *||Jun 4, 2002||May 15, 2003||Terwilliger Richard A.||Delivery system and method for interstitial radiation therapy using seed elements with ends having one of projections and indentations|
|US20030147501 *||Feb 14, 2003||Aug 7, 2003||Geitz Kurt Alfred Edward||Heat sink for miniature x-ray unit|
|US20040158116 *||Feb 10, 2004||Aug 12, 2004||Mawad Michel E.||Retrievable, shielded radiotherapy implant|
|US20050080314 *||Oct 9, 2003||Apr 14, 2005||Terwilliger Richard A.||Shielded transport for multiple brachytheapy implants with integrated measuring and cutting board|
|US20060069298 *||Oct 28, 2005||Mar 30, 2006||World Wide Medical Technologies, Llc||Delivery system and method for interstitial radiation therapy|
|US20060074270 *||Oct 28, 2005||Apr 6, 2006||World Wide Medical Technologies, Llc||Delivery system and method for interstitial radiation therapy using seed strands with custom end spacing|
|US20060089520 *||Nov 15, 2005||Apr 27, 2006||Terwilliger Richard A||Delivery system and method for interstitial radiation therapy using custom end spacing|
|US20060155241 *||Nov 17, 2005||Jul 13, 2006||Constantz Brent R||Proton generating catheters and methods for their use in enhancing fluid flow through a vascular site occupied by a calcified vascular occlusion|
|US20060235365 *||Jun 16, 2006||Oct 19, 2006||World Wide Medical Technologies, Llc|
|US20060264688 *||Apr 24, 2006||Nov 23, 2006||World Wide Medical Technologies, Llc||Strand with end plug|
|US20070191669 *||Mar 27, 2007||Aug 16, 2007||Worldwide Medical Technologies Llc||Strand with end plug|
|US20080269540 *||Apr 25, 2008||Oct 30, 2008||Worldwide Medical Technologies Llc||Seed cartridge adaptor and methods for use therewith|
|US20090099402 *||Dec 15, 2008||Apr 16, 2009||Biocompatibles Uk Limited||Implants for use in brachytherapy and other radiation therapy that resist migration and rotation|
|US20090124846 *||Jan 21, 2009||May 14, 2009||Biocompatibles Uk Limited||Anchor seed cartridge for use with brachytherapy applicator|
|US20090149692 *||Feb 18, 2009||Jun 11, 2009||Biocompatibles Uk Limited||Implants for use in brachytherapy and other radiation therapy that resist migration and rotation|
|EP0593136A1 *||Dec 11, 1990||Apr 20, 1994||Robert E. Fischell||Device for the prevention of arterial restenosis|
|EP1208874A1||Nov 17, 2000||May 29, 2002||MDS Nordion Inc.||Radioactive medical device for radiation therapy|
|WO1990003827A1 *||Oct 5, 1989||Apr 19, 1990||Michael H Hayman||Apparatus for in situ radiotherapy|
|U.S. Classification||600/3, 250/493.1|
|International Classification||A61M36/00, A61N5/10|
|Cooperative Classification||A61N2005/1019, A61N5/1002|