|Publication number||US3830239 A|
|Publication date||Aug 20, 1974|
|Filing date||Sep 12, 1972|
|Priority date||Sep 12, 1972|
|Also published as||CA989633A, CA989633A1, DE2345771A1, DE2345771C2|
|Publication number||US 3830239 A, US 3830239A, US-A-3830239, US3830239 A, US3830239A|
|Inventors||Andera J, Stumpf J|
|Original Assignee||Frigitronics Of Conn Inc|
|Export Citation||BiBTeX, EndNote, RefMan|
|Patent Citations (7), Referenced by (97), Classifications (8), Legal Events (8)|
|External Links: USPTO, USPTO Assignment, Espacenet|
Stumpf et a].
[ CRYOSURGICAL DEVICE  Inventors: Joseph G. Stumpf, Fairfield; Joseph F. Andera, Trumbull, both of Conn.
 Assignee: Frigitronics 01 Conn., 1nc., Shelton,
 Filed: Sept. 12, 1972 ] Appl. No.: 288,363
 U.S. Cl l28/303.1, 62/293, 62/294  Int. Cl A61b 17/36  Field of Search 62/293, 294; 128/303.l; 222/81  References Cited UNITED STATES PATENTS 1,617,066 2/1927 Lush 222/81 1,897,723 2/1933 Free 62/294 3,190,081 6/1965 Pytryga l28/303.1 UX 3,434,477 3/1969 Thomas, Jr. 128/303.1 3,524,446 8/1970 Crump 128/303.l 3,575,176 4/1971 Crump 128/3031 3,618,610 11/1971 Hannant 128/303.1
11] 3,830,239 Aug. 20, 1974 Primary Examiner-Channing L. Pace Attorney, Agent, or Firm-Buckles and Bramblett [5 7 ABSTRACT The foregoing abstract is not to be taken either as a complete exposition or as a limitation of the present invention. In order to understand the full nature and extent of the technical disclosure of this application, reference must be had to the following detailed description and the accompanying drawings as well as to the claims.
12 Claims, 4 Drawing Figures CRYOSURGICAL DEVICE BACKGROUND OF THE INVENTION This invention pertains to a cryosurgical device employing a low boiling temperature liquid refrigerant. More particularly, it relates to such a device which is self-contained, disposable, and of small size rendering it particularly useful for the cryoextraction of cata racts.
A number of cryosurgical devices have been known to the prior art which are self-contained units and which customarily employ a low boiling refrigerant, such as Freon. Examples of such devices will be found in the following U.S. Pat. Nos.:
2,645,097 Posch 3,343,544 Dunn et al.
3,524,446 Crump et al.
3,529,131 Kanbar et al.
3,575,176 Crump et al.
All of the foregoing are characterized by being selfcontained units which enclose a container of pressurized, low boiling temperature, liquid refrigerant. The refrigerant is selectively released from the container into a separate boiler tip. Boiling of the refrigerant reduces the temperature of the tip which is thereupon used for the surgical procedure. One such surgical procedure is adhesion to a cataractous lens for its removal in cataract surgery. Another type of prior art device is disclosed in U.S. Pat. No. 3,270,744 of Katz et al. That device, however, is not normally in a ready condition. It is always vented and accordingly must be separately filled with liquid nitrogen for each use.
It is an object of the present invention to provide a cryosurgical device which is disposable and of small size. Other objects are to provide such a device which is maintained ready for use over long periods of time; which may be simply and quickly actuated when desired; and which does not require transport of liquid refrigerant from its normal container to a separate boiling chamber.
The manner in which the foregoing objects are achieved will be apparent from the following description and appended claims.
SUMMARY OF THE INVENTION In accordance with the present invention there is provided a self-contained, disposable, cryosurgical device incorporating an elongated, sealed container having a first end terminating in a heat conductive tip, and a second end. A liquefied refrigerant partially fills the container and is normally maintained therein at superatmospheric pressure. An insulating housing substantially encloses the container and exposes at least a portion of the tip. Means are provided for selectively venting the container to atmosphere to boil the refrigerant and cool the tip.
BRIEF DESCRIPTION OF THE DRAWING FIG. 1 is a perspective view of a cryosurgical apparatus in accordance with this invention;
FIG. 2 is an enlarged vertical cross section of the apparatus of FIG. 1;
FIG. 3 is a-further enlarged cross section of the operating mechanism of the device of FIG. 2; and
FIG. 4 is a view similar to FIG. 3 illustrating an alternative operating mechanism.
DESCRIPTION OF THE PREFERRED EMBODIMENT With particular reference to FIGS. 1 and 2, there is illustrated a cryosurgical device in accordance with this invention which has the same size and shape as a conventional ballpoint pen. It comprises a housing 10 comprising an upper housing 10a, a central barrel 10b, and a tip housing 10c. The housing is preferably formed of a material having poor heat conductance, such as nylon, polypropylene, an acrylic, or other suitable material. Upper housing 1.0a is closed at its upper end but defines a crylindrical guideway 12 and small vents 13. The inside of barrel 10b has a substantially cylindrical surface 14. The tip housing 10c has an internal tapering surface 16 terminating in a cylindrical passage 18.
Mounted within the housing 10 is a refrigerant container 20. As will be seen from FIG. 3, the upper end of container 20 defines a circular shoulder 22 defining a central opening 24. A cup shaped cap 26 is crimped over the shoulder 22 and defines a central opening 28. Sealed between the upper end of the container 20 and the cap 26 is a rubber diaphragm 30. The tapered lower end of container 20 terminates at a solid, rod-like tip 32 at a matching conical portion 34 of the tip. The tip portions 32, 34 are fabricated from a suitable heat conductive material. -It is important to note that container 20 is secured within the housing 10 by contact made only at the cap 26 and at the tip portion 34. The remainder of the container is displaced from the housing 10 to provide a dead air insulating space 36.
Mounted in the guideway 12 of upper housing 10a is an actuating plunger 38 upon which is mounted a hollow needle 44 aligned with the opening 28 in cap 26. A small vent hole 46 is drilled in the side of the hollow needle 44. Contained within upper housing is a plug 47 of felt or other porous, fibrous, or blotter-like material. The plug 47 defines a passage 49 for needle 44.
The device of this invention is supplied to the surgeon with the container 28 partially filled with a suitable liquid refrigerant 51, such as Freon 12 or Freon 500. For cataract surgery the apparatus is normally used in an upright position, such as illustrated in FIG. 2. In this position there is a vapor space in the upper region of the container 20. The sealing action of diaphragm 30 causes the vapor and liquid refrigerant to be maintained under pressure at room temperature. When employing Freon 12, this pressure is approximately psig while, when employing Freon 500, the pressure is approximately psig.
When the surgeon wishes to activate the device, he simply depresses the actuating plunger 38. This causes the needle 44 to pierce the diaphragm 30. The vaporized refrigerant then passes into needle 44 and through vent hole 46, plug 47, and vents 13 to atmosphere. Reduction of the pressure within container 20 to atmosphere causes the remaining liquid refrigerant to immediately begin boiling and the entire volume of liquid refrigerant drops to its boiling temperature. For Freon 12 this is -21F, for Freon 500 it is 28F. This causes heat to be rapidly extracted from the tip 32, reducing its temperature and permitting it to be employed for the preferred surgical operation. For a device of the described size, the tip temperature remains at this lower value for approximately 4 minutes, a time amply sufficient to perform the usual cryoextraction. After use, the instrument is simply discarded.
The function of the plug 47 is to soak up any liquid refrigerant while allowing gaseous refrigerant to pass. Several conditions may cause liquid to be present in the upper housing including: the container being too full; violent boiling of the liquid; sloshing of the liquid due to motion of the surgeons hand; or activation while in other than a vertical position.
An alternative embodiment of the invention is illustrated in FIG. 4. In this embodiment, the needle and diaphragm are replaced by a conventional valve. In the illustration of FIG. 4, parts similar to those previously described have been given identical numerals but with a prime attached. In this embodiment, the puncturable diaphragm is replaced by a valving diaphragm 50 which has an outer annular flange 52 which is engaged by the crimped cap 54 to retain it in place. The valve diaphragm has an enlarged central portion 56 which seals the container by contacting the central opening 58 in the cap. A sidewardly positioned vent 60 in the diaphragm is normally closed by engagement with the cap. The hollow needle is replaced by a reduced diameter stem 62 on the end of a plunger 64. Downward movement of the plunger depresses the central portion 56 of the diaphragm permitting the vapor to exhaust through vent 60 and opening 58 to atmosphere. In the version illustrated in FIG. 4, the plunger 64 is retained in the open valve position by means of a detent 66 which overrides an internal shoulder 68 in the housing. This construction could be modified by making plunger 64 retractable, such as the button on a ballpoint pen. The valve could then be closed to permit defrosting during a surgical procedure.
It is believed that the many advantages of this invention will now be apparent to those skilled in the art. It will be particularly apparent that no transfer of the refrigerant is required in order to effectuate the desired cooling. As a result, the device is much smaller and of simpler construction than devices known to the prior art. It will also be apparent that a number of variations and modifications may be made in this invention without departing from its spirit and scope. Accordingly, the foregoing description is to be construed as illustrative only, rather than limiting. This invention is limited only by the scope of the following claims.
1. A self-contained, disposable cryosurgical device which comprises: an elongated, sealed container having a first end terminating in an integral heat conductive applicator tip, and a second end; a liquefied refrigerant partially filling said container to define a vapor space therein and normally maintained at super atmospheric pressure, said liquid being in direct physical contact with said tip; an insulating housing substantially enclosing said container but exposing at least a portion of said tip; and means at said second end for selectively venting the vapor space of said container to atmosphere to boil said refrigerant and cool said container and tip.
2. The device of claim 1 wherein said venting means comprises a porous member for passage of refrigerant therethrough.
3. The device of claim ll wherein said venting means comprises a needle actuatable to puncture the second end of said container.
4. The device of claim 3 wherein said needle is secured to an actuating plunger supported in said housing.
5. The device of claim 4 wherein said venting means comprises a porous member surrounding said needle.
6. The device of claim 1 wherein the second end of said container comprises an elastomeric diaphragm.
7. The device of claim 6 wherein said venting means comprises a needle actuatable to puncture said diaphragm.
8. The device of claim 7 wherein said needle is secured to an actuating plunger supported in said housmg.
9. The device of claim 1 wherein the second end of said container comprises a valve and said venting means comprises a valve actuator.
10. The device of claim 9 wherein said valve actuator comprises a plunger supported in said housing.
11. The device of claim 10 wherein said valve comprises an elastomeric diaphragm normally sealing said second end but movable to an open position by said plunger.
12. The device of claim 11 wherein said plunger includes means for retaining said diaphragm in its open position.
|Cited Patent||Filing date||Publication date||Applicant||Title|
|US1617066 *||Nov 3, 1925||Feb 8, 1927||Lush Studley Woolcott||Means for decanting liquids from metal containers|
|US1897723 *||Apr 29, 1927||Feb 14, 1933||Free Walter H||Refrigerating device|
|US3190081 *||Jul 26, 1963||Jun 22, 1965||Sulfrian Cryogenics Inc||Cryogenic applicator with probe means|
|US3434477 *||Nov 23, 1966||Mar 25, 1969||Univ Northwestern||Surgical instrument|
|US3524446 *||May 31, 1968||Aug 18, 1970||Frigitronics Of Conn Inc||Disposable cryosurgical instrument|
|US3575176 *||Oct 21, 1968||Apr 20, 1971||Frigitronics Of Conn Inc||Rechargeable cryosurgical instrument|
|US3618610 *||Apr 22, 1970||Nov 9, 1971||Kidde & Co Walter||Cryogenic surgical apparatus|
|Citing Patent||Filing date||Publication date||Applicant||Title|
|US4602628 *||Jan 17, 1985||Jul 29, 1986||Allen Jr Robert E||Cryogenic extractor and filler|
|US4735063 *||Apr 13, 1987||Apr 5, 1988||Superior Marketing Research Corp.||Self-contained cooling device|
|US5042261 *||Jan 30, 1990||Aug 27, 1991||Cornwell Corporation||Tissue freezing process|
|US6039730 *||Jun 24, 1996||Mar 21, 2000||Allegheny-Singer Research Institute||Method and apparatus for cryosurgery|
|US6161543 *||Oct 15, 1997||Dec 19, 2000||Epicor, Inc.||Methods of epicardial ablation for creating a lesion around the pulmonary veins|
|US7083620||Jul 17, 2003||Aug 1, 2006||Medtronic, Inc.||Electrosurgical hemostat|
|US7094235||Jan 13, 2004||Aug 22, 2006||Medtronic, Inc.||Method and apparatus for tissue ablation|
|US7118566||Feb 3, 2003||Oct 10, 2006||Medtronic, Inc.||Device and method for needle-less interstitial injection of fluid for ablation of cardiac tissue|
|US7128740||Apr 2, 2003||Oct 31, 2006||Jacobs Clemens J||Method for interrupting conduction paths within the heart|
|US7156845||Sep 16, 2005||Jan 2, 2007||Medtronic, Inc.||Method and apparatus for creating a bi-polar virtual electrode used for the ablation of tissue|
|US7166105||Sep 20, 2005||Jan 23, 2007||Medtronic, Inc.||Pen-type electrosurgical instrument|
|US7169144||Oct 31, 2003||Jan 30, 2007||Medtronic, Inc.||Apparatus and method for creating, maintaining, and controlling a virtual electrode used for the ablation of tissue|
|US7247155||May 18, 2004||Jul 24, 2007||Medtronic, Inc.||Apparatus and method for creating, maintaining, and controlling a virtual electrode used for the ablation of tissue|
|US7250048||Aug 20, 2004||Jul 31, 2007||Medtronic, Inc.||Ablation system and method of use|
|US7250051||Apr 26, 2006||Jul 31, 2007||Medtronic, Inc.||Method and apparatus for tissue ablation|
|US7294143||Feb 3, 2003||Nov 13, 2007||Medtronic, Inc.||Device and method for ablation of cardiac tissue|
|US7309325||Jun 28, 2005||Dec 18, 2007||Medtronic, Inc.||Helical needle apparatus for creating a virtual electrode used for the ablation of tissue|
|US7347858||Oct 14, 2003||Mar 25, 2008||Medtronic, Inc.||Method and system for treatment of atrial tachyarrhythmias|
|US7364578||Dec 3, 2004||Apr 29, 2008||Medtronic, Inc.||System and method of performing an electrosurgical procedure|
|US7367972||Sep 9, 2003||May 6, 2008||Medtronic, Inc.||Ablation system|
|US7422588||Dec 7, 2006||Sep 9, 2008||Medtronic, Inc.||Pen-type electrosurgical instrument|
|US7435250||Feb 18, 2005||Oct 14, 2008||Medtronic, Inc.||Method and apparatus for tissue ablation|
|US7470272||Jun 30, 2004||Dec 30, 2008||Medtronic, Inc.||Device and method for ablating tissue|
|US7497857||Apr 29, 2003||Mar 3, 2009||Medtronic, Inc.||Endocardial dispersive electrode for use with a monopolar RF ablation pen|
|US7507235||May 28, 2002||Mar 24, 2009||Medtronic, Inc.||Method and system for organ positioning and stabilization|
|US7513891 *||Jul 15, 2005||Apr 7, 2009||Disetronic Licensing Ag||Temperature-sensitive cannula|
|US7566334||Jun 2, 2005||Jul 28, 2009||Medtronic, Inc.||Ablation device with jaws|
|US7615015||Nov 10, 2009||Medtronic, Inc.||Focused ultrasound ablation devices having selectively actuatable emitting elements and methods of using the same|
|US7628780||Dec 8, 2009||Medtronic, Inc.||Devices and methods for interstitial injection of biologic agents into tissue|
|US7678108||Jun 2, 2005||Mar 16, 2010||Medtronic, Inc.||Loop ablation apparatus and method|
|US7678111||Mar 16, 2010||Medtronic, Inc.||Device and method for ablating tissue|
|US7699805||Nov 30, 2007||Apr 20, 2010||Medtronic, Inc.||Helical coil apparatus for ablation of tissue|
|US7706882||May 13, 2005||Apr 27, 2010||Medtronic, Inc.||Methods of using high intensity focused ultrasound to form an ablated tissue area|
|US7706894||Apr 26, 2005||Apr 27, 2010||Medtronic, Inc.||Heart wall ablation/mapping catheter and method|
|US7740623||Jun 23, 2005||Jun 22, 2010||Medtronic, Inc.||Devices and methods for interstitial injection of biologic agents into tissue|
|US7744562||Oct 10, 2006||Jun 29, 2010||Medtronics, Inc.||Devices and methods for interstitial injection of biologic agents into tissue|
|US7758576||Jul 20, 2010||Medtronic, Inc.||Clamping ablation tool and method|
|US7758580||Jul 20, 2010||Medtronic, Inc.||Compound bipolar ablation device and method|
|US7794460||Sep 14, 2010||Medtronic, Inc.||Method of ablating tissue|
|US7818039||Oct 19, 2010||Medtronic, Inc.||Suction stabilized epicardial ablation devices|
|US7824399||Feb 16, 2006||Nov 2, 2010||Medtronic, Inc.||Ablation system and method of use|
|US7871409||Feb 2, 2009||Jan 18, 2011||Medtronic, Inc.||Endocardial dispersive electrode for use with a monopolar RF ablation pen|
|US7875028||Jan 25, 2011||Medtronic, Inc.||Ablation device with jaws|
|US7959626||Jun 14, 2011||Medtronic, Inc.||Transmural ablation systems and methods|
|US7963963||Jun 21, 2011||Medtronic, Inc.||Electrosurgical hemostat|
|US7967816||Jun 28, 2011||Medtronic, Inc.||Fluid-assisted electrosurgical instrument with shapeable electrode|
|US7975703||Aug 31, 2006||Jul 12, 2011||Medtronic, Inc.||Device and method for needle-less interstitial injection of fluid for ablation of cardiac tissue|
|US7998137||Apr 12, 2010||Aug 16, 2011||Myoscience, Inc.||Subdermal cryogenic remodeling of muscles, nerves, connective tissue, and/or adipose tissue (fat)|
|US8162933||Mar 3, 2004||Apr 24, 2012||Medtronic, Inc.||Vibration sensitive ablation device and method|
|US8162941||Apr 24, 2012||Medtronic, Inc.||Ablation device with jaws|
|US8172837||May 8, 2012||Medtronic, Inc.||Clamping ablation tool and method|
|US8221402||Jul 17, 2012||Medtronic, Inc.||Method for guiding a medical device|
|US8221415||Jul 17, 2012||Medtronic, Inc.||Method and apparatus for tissue ablation|
|US8262649||Jul 27, 2007||Sep 11, 2012||Medtronic, Inc.||Method and apparatus for tissue ablation|
|US8273072||Sep 25, 2012||Medtronic, Inc.||Devices and methods for interstitial injection of biologic agents into tissue|
|US8298216||Nov 14, 2008||Oct 30, 2012||Myoscience, Inc.||Pain management using cryogenic remodeling|
|US8333764||May 12, 2004||Dec 18, 2012||Medtronic, Inc.||Device and method for determining tissue thickness and creating cardiac ablation lesions|
|US8409185||Apr 2, 2013||Myoscience, Inc.||Replaceable and/or easily removable needle systems for dermal and transdermal cryogenic remodeling|
|US8409219||Apr 2, 2013||Medtronic, Inc.||Method and system for placement of electrical lead inside heart|
|US8414573||Oct 11, 2006||Apr 9, 2013||Medtronic, Inc.||Device and method for ablation of cardiac tissue|
|US8512337||Aug 20, 2004||Aug 20, 2013||Medtronic, Inc.||Method and system for treatment of atrial tachyarrhythmias|
|US8568409||Oct 31, 2007||Oct 29, 2013||Medtronic Advanced Energy Llc||Fluid-assisted medical devices, systems and methods|
|US8623010||Jun 9, 2009||Jan 7, 2014||Medtronic, Inc.||Cardiac mapping instrument with shapeable electrode|
|US8632533||Feb 23, 2010||Jan 21, 2014||Medtronic Advanced Energy Llc||Fluid-assisted electrosurgical device|
|US8663245||Apr 19, 2007||Mar 4, 2014||Medtronic, Inc.||Device for occlusion of a left atrial appendage|
|US8706260||Oct 27, 2011||Apr 22, 2014||Medtronic, Inc.||Heart wall ablation/mapping catheter and method|
|US8715275||Sep 13, 2012||May 6, 2014||Myoscience, Inc.||Pain management using cryogenic remodeling|
|US8801707||Aug 14, 2012||Aug 12, 2014||Medtronic, Inc.||Method and devices for treating atrial fibrillation by mass ablation|
|US8821488||May 13, 2009||Sep 2, 2014||Medtronic, Inc.||Tissue lesion evaluation|
|US8906012||Jun 30, 2010||Dec 9, 2014||Medtronic Advanced Energy Llc||Electrosurgical devices with wire electrode|
|US8926635||Oct 2, 2009||Jan 6, 2015||Medtronic, Inc.||Methods and devices for occlusion of an atrial appendage|
|US9017318||Jan 22, 2013||Apr 28, 2015||Myoscience, Inc.||Cryogenic probe system and method|
|US9066712||Dec 22, 2009||Jun 30, 2015||Myoscience, Inc.||Integrated cryosurgical system with refrigerant and electrical power source|
|US9072498||Nov 17, 2010||Jul 7, 2015||Myoscience, Inc.||Subdermal cryogenic remodeling of muscles, nerves, connective tissue, and/or adipose tissue (fat)|
|US9101346||Sep 30, 2013||Aug 11, 2015||Myoscience, Inc.||Pain management using cryogenic remodeling|
|US9113855||Mar 5, 2013||Aug 25, 2015||Myoscience, Inc.||Replaceable and/or easily removable needle systems for dermal and transdermal cryogenic remodeling|
|US9113896||Dec 28, 2007||Aug 25, 2015||Medtronic, Inc.||Method and apparatus for creating a bi-polar virtual electrode used for the ablation of tissue|
|US9155584||Jan 14, 2013||Oct 13, 2015||Myoscience, Inc.||Cryogenic probe filtration system|
|US9227088||May 3, 2010||Jan 5, 2016||Medtronic, Inc.||Methods of using high intensity focused ultrasound to form an ablated tissue area containing a plurality of lesions|
|US9241753||Jan 14, 2013||Jan 26, 2016||Myoscience, Inc.||Skin protection for subdermal cryogenic remodeling for cosmetic and other treatments|
|US9254162||Dec 21, 2006||Feb 9, 2016||Myoscience, Inc.||Dermal and transdermal cryogenic microprobe systems|
|US9295512||Sep 12, 2013||Mar 29, 2016||Myoscience, Inc.||Methods and devices for pain management|
|US9314290||Jan 14, 2013||Apr 19, 2016||Myoscience, Inc.||Cryogenic needle with freeze zone regulation|
|US9333027 *||Oct 3, 2013||May 10, 2016||Medtronic Advanced Energy Llc||Method of producing an electrosurgical device|
|US20060030824 *||Jul 15, 2005||Feb 9, 2006||Marcel Hunn||Temperature-sensitive cannula|
|US20080015562 *||Jul 20, 2007||Jan 17, 2008||Medtronic, Inc.||Transmural ablation systems and methods|
|US20080027419 *||Jul 25, 2007||Jan 31, 2008||Ams Research Corporation||Cryoprobe with Integral Agent Delivery Device|
|US20080091194 *||Nov 30, 2007||Apr 17, 2008||Mulier Peter M||Helical coil apparatus for ablation of tissue|
|US20080154254 *||Dec 21, 2006||Jun 26, 2008||Myoscience, Inc.||Dermal and Transdermal Cryogenic Microprobe Systems and Methods|
|US20080200910 *||Feb 16, 2007||Aug 21, 2008||Myoscience, Inc.||Replaceable and/or Easily Removable Needle Systems for Dermal and Transdermal Cryogenic Remodeling|
|US20080221561 *||Jul 17, 2006||Sep 11, 2008||Jorg Geiger||Spray Device for Dispensing a Cooling Fluid|
|US20090248001 *||Nov 14, 2008||Oct 1, 2009||Myoscience, Inc.||Pain management using cryogenic remodeling|
|US20090270857 *||Oct 29, 2009||Christian Steven C||Ablation Device with Jaws|
|US20100145361 *||Oct 2, 2009||Jun 10, 2010||Francischelli David E||Methods and Devices for Occlusion of an Atrial Appendage|
|US20100198207 *||Apr 12, 2010||Aug 5, 2010||Myoscience, Inc.||Subdermal cryogenic remodeling of muscles, nerves, connective tissue, and/or adipose tissue (fat)|
|US20140026395 *||Oct 3, 2013||Jan 30, 2014||Medtronic Advanced Energy Llc||Fluid-assisted electrosurgical devices, and methods of manufacture thereof|
|WO1997049344A1 *||Jun 20, 1997||Dec 31, 1997||Allegheny-Singer Research Institute||Method and apparatus for cryosurgery|
|U.S. Classification||606/25, 62/293, 62/294|
|International Classification||A61B18/00, A61F9/007, A61B18/02|
|Mar 11, 1992||AS||Assignment|
Owner name: COOPERVISION, INC. A NY CORPORATION, NEW YORK
Free format text: NUNC PRO TUNC ASSIGNMENT;ASSIGNOR:FRIGI ACQUISITION, INC., A CORPORATION OF DE;REEL/FRAME:006047/0568
Owner name: FRIGI ACQUISITION, INC., CONNECTICUT
Free format text: NUNC PRO TUNC ASSIGNMENT;ASSIGNOR:COOPERVISION, INC. A CORP. OF NEW YORK;REEL/FRAME:006047/0578
Effective date: 19911004
|Mar 11, 1992||AS27||Nunc pro tunc assignment|
Free format text: FRIGI ACQUISITION, INC. A DE CORP. 770 RIVER ROAD SHELTON, CONNECTICUT 06484 * COOPERVISION, INC. ACORP. OF NEW YORK : 19911004
|Jul 16, 1990||AS||Assignment|
Owner name: FRIGITRONICS OF CONN., INC.
Free format text: RELEASED BY SECURED PARTY;ASSIGNOR:BANK OF NEW YORK COMMERCIAL CORPORATION, THE;REEL/FRAME:005395/0050
Effective date: 19900612
|Mar 28, 1990||AS||Assignment|
Owner name: FRIGI ACQUISITION, INC., 3145 PORTER DRIVE, PALO A
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|May 20, 1988||AS06||Security interest|
Owner name: BANK OF NEW YORK COMMERCIAL CORPORATION, THE, 530
Owner name: FRIGITRONICS OF CONNECTICUT, INC.,
Effective date: 19870724
|May 20, 1988||AS02||Assignment of assignor's interest|
Owner name: FRIGITRONICS INC., A DE CORPORATION
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|May 20, 1988||AS||Assignment|
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Free format text: SECURITY INTEREST;ASSIGNOR:FRIGITRONICS OF CONNECTICUT, INC.,;REEL/FRAME:004935/0800
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|Oct 26, 1987||AS||Assignment|
Owner name: FRIGITRONICS, INC., A CORP. OF DE
Free format text: MERGER;ASSIGNORS:FRIGITRONICS, INC., A CORP. OF CT.;FRIGITRONICS OF CONN., INC., A CORP. OF CT;REEL/FRAME:004858/0780;SIGNING DATES FROM 19680314 TO 19861208