|Publication number||US3831606 A|
|Publication date||Aug 27, 1974|
|Filing date||Oct 24, 1973|
|Priority date||Feb 19, 1971|
|Publication number||US 3831606 A, US 3831606A, US-A-3831606, US3831606 A, US3831606A|
|Original Assignee||Alza Corp|
|Export Citation||BiBTeX, EndNote, RefMan|
|Patent Citations (15), Referenced by (106), Classifications (6)|
|External Links: USPTO, USPTO Assignment, Espacenet|
United States Patent [191 amani 1 1 AUTO INHALER  Filed: Oct. 24, 1973  Appl. No.: 409,243
Related 1.1.8. Application Data  Continuation of Ser. No. 117,015, Feb. 19, 1971,
 11.8. CI 128/266, 128/208, 222/193  Int. Cl. A61m 15/08, A61m 13/00  Field of Search 128/266, 265, 173 R, 185, 128/188, 195, 196, 198201, 205, 206, 208, 142.3; 222/193; 46/10, 68
 References Cited UNITED STATES PATENTS 1,272,283 7/1918 Madden 222/193 1,526,096 2/1925 Sims 128/266 1,864,188 6/1932 Deutsch 128/173 R 2,147,435 2/1939 Gehrcke 128/266 2,163,185 6/1939 Belstrup 46/68 2,483,148 9/1949 Nicolle 222/193 2,693,805 11/1954 Taplin et a1 128/266 3,378,005 4/1968 Smith, Jr 128/188 3,535,707 10/1970 Greenlee l28/143.3 3,696,973 10/1972 Cottell 222/193 FOREIGN PATENTS OR APPLICATIONS 2,023,891 ll/l970 Germany 128/266 Primary Examiner-Richard A. Gaudet Assistant Examiner-.1. C. McGowan Attorney, Agent, or Firm-Thomas E. Ciotti; Edward L. Mandell; Paul L. Sabatine ABSTRACT An improved device and process for the oral inhalation of medicaments in finely divided form is disclosed. The device has a hollow elongate housing having one end adapted for insertion into the oral or nasal cavity of a user, this end having at least one air passageway therein. There is at least one other air passageway near the other end of the housing. A propeller attached to a medicament container is rotatably mounted in the housing. Piercing members are provided for perforating the medicament container. There is also a self-contained power source for rotating the propeller and the medicament container to dispense the medicament in a positive pressure airstream. Optionally, the device contains an atomizer rotatably mounted in the housing intermediate the medicament container and the medicament dispensing end of the device.
4 Claims, 3 Drawing Figures PATENTED 35831 @606 INVENTOR NALINKANT C. DAMANI AUTO INHALER This is a continuation; of application Ser. No. 117,015, filed Feb. 19, 1971, now abandoned.
BACKGROUND OF THE INVENTION This invention relates to the administration of drugs to a patient via inhalation through the oral and/or nasal passages, and more especially to a device which propels a uniform dosage of finely divided medicament into the lungs through the aforementioned passages.
In the past, administration of medicaments for the alleviation of ailments of the lungs has been carried out using plastic squeeze bottles or aerosol cans to deliver drugs through the oral and/or nasal cavities. Devices of this type have not been entirely satisfactory because they do not allow the user to properly control the medicament concentration or dosage. Furthermore, significant problems arise as a result of the variation in particle size of the medicament spray delivered from these devices. Thus, it is not always possible with these devices to dispense a medicament in the form of very fine and uniform particle size or mist which can be readily inhaled by the user. Sonic generators have proven to be the only truly effective devices for accomplishing complete control of both medicament dosage and particle size; however, these are extremely large and can be used only in a hospital, doctors office, clinic, etc. There have also been attempts to provide smaller, pocket-sized inhalation devices which may be used in any location to supply the necessary medication. Many of these personal sized devices are based upon aerosol principles (see for example, U.S. Pat. Nos. 3,183,907, 3,456,645, and 3,456,646 and of necessity suffer from the aforementioned disadvantages associated with aerosolized atomizers. Most recent endeavors in the area of pocket size atomizers are exemplified by U.S. Pat. Nos. 3,507,277 and 3,518,992 wherein the medicament is placed in the inhaler in capsulized form, made of gelatin or other material, and thereafter the capsule is perforated in situ to render the medicament available immediately prior to its contemplated use. The user then inhales through the device which causes an internally contained propeller, well as the punctured capsule, to rotate thereby dispensing the medicament from the device and into the oral or nasal passages ofthe user. While these latter type of devices may solve the heretofore mentioned medicament dosage and particle size problems, they too are rendered not wholly effective because typically those people having ailments necessitating the subject medication, as for example asthmatic patients, cannot efficiently draw air through their oral or nasal passages, and, as a result, they often cannot administer to themselves the entire medicament dosage. In fact, those persons most in need of the drug are those who are least able to draw air, and hence medicament. through the device.
SUMMARY OF THE INVENTION Accordingly, it is a primary object of this invention to provide an inhalation device which is capable of dispensing a precise quantity of medicament in extremely uniform particle size to any patient regardless of his ability to inhale.
Another object of this invention is to provide an improved inhalation device which can deliver in uniform particle size a medicament in either liquid, microencapsulated, or dry power form without the use of Freon or similar aerosolizing material.
In attaining the objects of this invention, one feature resides in a device for the oral inhalation of medicaments in finely divided form which comprises a hollow elongate housing having one end adapted for insertion into the oral or nasal cavity of a user. The end soadapted is provided with at least one air passageway therein, and there is provided at least one other air passageway near the other end of the housing. Inside the housing there is rotatably mounted a propeller means, and attached thereto is a mounting means for receiving a container of medicament. The device also contains one or more piercing members for perforating the container while it is contained in the aforementioned mounting means, such piercing members typically being spring-biased or loaded. The device is particu- Iarly characterized by a self-contained power source for operating the propeller means via external manual manipulation by the user. One such power source comprises an electric motor, battery and external switch combination, while an alternative embodiment includes a threaded plunger arrangement. In a further embodiment the device contains an atomizing means rotatably mounted inside the housing intermediate the medicament container mounting means and the housing end adapted for insertion into the oral or nasal cavity of a user. This atomizer is employed when the medicament is present in other than dry particulate form. In a typical embodiment, the spring-loaded piercing members include exteriorly located push button means attached thereto allowing the user to press the piercing members into the medicament container.
BRIEF DESCRIPTION OF THE DRAWINGS FIG. 1 is a cross-sectional view of an oral inhalation device according to this invention wherein the power source is an electric motor;
FIG. 2 is a cross-sectional view of another embodiment of the present invention wherein a plunger is employed as the power source; and
FIG. 3 is a view along the line 3-3 in FIG. 2 illustrating an atomizer disc which may optionally be included in the devices of this invention.
DETAILED DESCRIPTION OF THE INVENTION In one embodiment in accordance with this invention, as illustrated in FIG. 1, an oral inhalation device 10 is comprised of a rigid, hollow cylindrical housing 12 having its upper end adapted for insertion into the oral or nasal cavity of a user. Located in the upper end wall are a plurality of passageways 14 communicating with the inside of the housing and allowing free passage of air and medicament therethrough. Near the lower endof the housing 12 are located another series of similar passageways 16 providing for the ingress of air into the inhalation device. Propeller 18 is rotatably mounted on shaft 19 inside of housing 12. Immediately above propeller l8 and likewise connected to shaft 19 is a cup-like mounting means 20 for receiving a con-. tainer of medicament such as capsule 22. This entire assembly comprised of mounting means 20, propeller l8 and shaft 19 is driven by a small battery powered electric motor 24 secured to housing 12 immediately beneath the indicated assembly. A battery 26, typically size N or smaller, is also contained within housing 12 and is connected to motor 24 through conductors 28 and 29. Selective operation of motor 24 is achieved through operation of push button 30 located on the ex terior of housing 12 adjacent to battery 26.
In the sidewall portions of housing 12 immediately adjacent medicament container mounting means are located two spring-loaded piercing members 31 and 32 by means of which the user may pierce the medicament container 22, while in its supporting member 20. immediately prior to desired use of the device. The piercing members are conveniently actuated by the push button members 33 and 34 connected thereto on the external side of housing 12; however, other actuating means may also be employed for this purpose. For purposes of illustration, one assembly is shown in the non-piercing posit-ion whereas the other assembly is shown with the tip of piercing member 31 having pierced capsule 22. Preferably, the perforating ends of piercing members 31 and 32 are sharpened with a plane face at an acute angle, and furthermore, the acute angled plane face desirably faces away from propeller 18. Actuation of the piercing members advantageously provides one or more holes, suitably of about 0.6 to 0.65 mm. in diameter, in the capsule wall. It will of course be appreciated that any other suitable medicament container piercing assembly may be employed in the device of this invention, for example, one such as that disclosed in U.S. Pat. No. 3,518,992.
Medicament containing capsule 22 can be a standard capsule of gelatin or other material having'the medicament contained therein in either dry powder, microencapsulated, or liquid form. After piercing of the capsule walls has taken place, medicament will be forced out of the capsule into the positive pressure air stream created by propeller 18 as a result of the forces created by the rotational movement of the capsule itself.
When the medicament in capsule 22 is in liquid form, and in certain other instances, it is desired to further employ an atomizing disc 36 between the medicament container mounting means 20 and the medicament dispensing end of the device. The atomizing disc 36 is secured to shaft 17 and the resultant assembly is likewise secured to inverted cup-like member 21 which may be removably engaged over cup-like mounting member 20 which receives and holes the medicament capsule 22. Thus, inverted cup-like member 21 rotates together with mounting means 20, and as a result, atomizing disc 36 is likewise caused to rotate. For support and stabilization, shaft 17 loosely engages with bearing member 15 contained in housing 12. Inverted cup-like member 21 advantageously is of a cage-like configuration having only a few relatively narrow support members (preferably having no two support members lying on any one diameter across member 21) thereby providing openings 23 around substantially the entire circumference of member 21 to facilitate easy entrance by piercing members 31 and 32.
A planar view of atomizer disc 36 is illustrated in FIG. 3. The disc contains a plurality of apertures 37 uniformly distributed thereover, the same being for the purpose of assuring substantially uniform medicament particle size when capsule 22 contains medicament in the form of a liquid or any other form which is likely to agglomerate.
Referring now to FIG. 2, there is illustrated an alternative embodiment of the oral inhalation device of the invention. The portion of the device extending from propeller 18 to the medicament dispensing end of the device is essentially identical to the corresponding portion of the device illustrated in FIG. 1. In FIG. 2, a spring-loaded plunger assembly is employed as the power source in lieu of the battery operated electric motor illustrated in FIG. 1. The plunger assembly consists of plunger 40 slidably mounted in sleeve 42 at the lower end wall of housing 12. Plunger 40 is biased downwardly by spring 43 and retained in the device by cooperation of flange 44 with sleeve 42. Near the upper end of plunger 40 are located a plurality of ball bearings 45 which are freely rotatable and cooperate with threads 46 contained on the lower portion of shaft 19. Thus, when plunger 40 is depressed into housing 12, ball bearings 45 travel upwardly in threads 46 causing rotation of shaft 19 and hence propeller 18, medicament container support 20 and optionally atomizing disc 36. It will be appreciated that suitable gearing linkages may be incorporated into the plunger assembly to selectively vary the amount of rotation generated by each depression of plunger 40.
In operation, the two sections of housing 12 are separated and a container of medicament, such as a capsule, is placed into support 20. At this time, the atomizer disc assembly may be inserted or removed as desired. The housing is again closed, and the device may now be carried by the user for an indefinite period of time without deterioration or loss of medicament. When the administration of medicament is required, the user depresses push-buttons 33 and 34 to puncture the capsule in situ, and thereafter places the dispensing end of the device into his oral or nasal cavity, whereupon medicament may then be dispensed by either activation of electric motor 24 via push button 30 or depression of plunger 40.
The drug present in capsule 22 may be either a single or multiple dosage. For a single dosage, the device is constructed so that all of the medicament is delivered with a single push of the plunger 40 or depression of switch 30. In the case of a multiple dosage containing capsule, the device may be designed to administer only a single dose on each push of plunger 40 or timed depression of button 30. Repetition of this action similarly delivers the second and subsequent doses of the medicament. The embodiment illustrated in FIG. 2 is especially suited for such a modification.
Thus, the invention provides an oral inhalation device suitable for the administration of exact dosages of medicaments in finely divided form for the alleviation of ailments of the bronchial tract and of the lungs. The device may also be used for the administration of medicaments having systemic action, for example, it may be used for the administration of an antidote to poisonous substances. The device provides a simple method of carrying medicaments which require rapid or emergency usage, and moreover the device assures that a uniform dosage of such a medicament is administered regardless of the users ability to properly inhale.
While the invention has been described and illustrated with reference to certain preferred embodiments thereof, those skilled in the art will appreciate that various modifications, changes, omissions and substitutions can be made without departing from the spirit of the invention. It is intended, therefore, that the invention be limited only by the scope of the following claims.
What is claimed is:
l. A device for the dispensing of medicament in finely divided form for oral or nasal inhalation which comprises a rigid hollow elongate cylindrical housing having one end adapted for insertion into the oral or nasal cavity of a user, said one end having at least one air outlet passageway therein and there being at least one air inlet passageway near the other end of said housing; shaft means rotatably mounted axially within said housing; airstream generator means in the form of a propeller attached to said shaft; mounting means for receiving a container of medicament attached to said shaft downstream of said propeller; means for perforating holes in said container while said container is in said mounting means; power rotating means contained within said housing and attached to said shaft means for rotating said shaft means, for rotating said propeller means to direct an airstream around said container to said air outlet passageway, and for rotating said mounting means and container to rotationally force medicament out of said container through said holes into said airstream; and atomizing means mounted on said shaft for rotation at a fixed longitudinal position in said housing intermediate the medicament container mounting means and the housing end adapted for insertion into the oral or nasal cavity of a user.
2. A process of dispensing medicament in finely divided form for oral or nasal inhalation which comprises: providing a rigid hollow elongate cylindrical housing having one end adapted for insertion into the oral or nasal cavity of a user; forming at least one air outlet passageway in said end of said housing; forming at least one air inlet passageway near the other end of said housing; rotatably mounting a shaft axially within said housing; attaching a propeller to said shaft; mounting a medicament container in said housing attached to said shaft; mounting an atomizing means on said shaft in said housing intermediate the medicament container and the housing end adapted for insertion into the oral or nasal cavity of a user; perforating said container while the same is mounted in said housing; and power rotating said shaft to drive said propeller such that a positive pressure airstream is created from said air inlet passageway to said air outlet passageway, said powered rotation of said shaft further rotating said container to rotationally force medicament out of said container through said holes into said airstream whereby a dosage of medicament is dispensed for inhalation.
3. The process of claim 2 wherein said power rotating step comprises driving said shaft with a self-contained, batterypowered electric motor.
4-. The process of claim 2 wherein said power rotating step comprises driving said shaft by movement of a plunger assembly.
|Cited Patent||Filing date||Publication date||Applicant||Title|
|US1272283 *||Feb 7, 1918||Jul 9, 1918||Jeremiah M Madden||Insect-destroyer.|
|US1526096 *||Jun 7, 1924||Feb 10, 1925||Eugene Sims Carl||Powder ejector|
|US1864188 *||Jun 25, 1928||Jun 21, 1932||Electric Sprayit Company||Spraying device|
|US2147435 *||May 24, 1935||Feb 14, 1939||Ernst Gehrcke||Apparatus and method for improving the air|
|US2163185 *||May 18, 1935||Jun 20, 1939||Vilhelm Belstrup Frederik||Whirligig|
|US2483148 *||Aug 27, 1945||Sep 27, 1949||Charles Nicolle||Apparatus for the distribution of pulverulent products|
|US2693805 *||Nov 26, 1949||Nov 9, 1954||Bryan Frederick A||Apparatus for administering therapeutic agents|
|US3378005 *||Jan 14, 1965||Apr 16, 1968||Raymond M. Smith Jr.||Anesthetic apparatus|
|US3535707 *||Mar 3, 1969||Oct 27, 1970||Trison Corp||Welding helmet and the like|
|US3696973 *||Dec 9, 1969||Oct 10, 1972||Cottell Eric Charles||Hand-held air compressor and liquid spray device|
|DE498874C *||Aug 17, 1929||May 31, 1930||Philipp Sachs||Spielflugzeug, bei dem der Propeller dadurch in Umdrehung versetzt wird, dass eine mit Gewinde Versehene Stange durch ein mit dem Propeller fest verbundenes Gewinde hindurchgefuehrt wird|
|DE2023891A1 *||May 15, 1970||Nov 19, 1970||Fisons Pharmaceuticals Ltd||Vorrichtung zur oralen Inhalation eines pulverfoermigen Medikamentes|
|DK114218B *||Title not available|
|FR1389559A *||Title not available|
|PL34867A *||Title not available|
|Citing Patent||Filing date||Publication date||Applicant||Title|
|US3888253 *||Jun 7, 1974||Jun 10, 1975||Beecham Group Ltd||Device for administration of medicines|
|US3921637 *||Jul 22, 1974||Nov 25, 1975||Bespak Industries Ltd||Inhaler for powdered medicament|
|US3931914 *||Jun 3, 1974||Jan 13, 1976||Max Kabushiki Kaisha||Powder ejector|
|US3949751 *||Aug 26, 1974||Apr 13, 1976||Fisons Limited||Method and device for dispensing medicament to the body|
|US3971377 *||Jul 21, 1975||Jul 27, 1976||Alza Corporation||Medicament dispensing process for inhalation therapy|
|US4147166 *||May 2, 1977||Apr 3, 1979||American Cyanamid Company||Oral inhalator powder dispenser|
|US4524769 *||Jun 17, 1982||Jun 25, 1985||Aktiebolaget Draco||Dosage inhalator|
|US4534345 *||Jun 30, 1982||Aug 13, 1985||Aktiebolaget Draco||Dosage inhalator|
|US5327883 *||May 20, 1991||Jul 12, 1994||Dura Pharmaceuticals, Inc.||Apparatus for aerosolizing powdered medicine and process and using|
|US5577497 *||Oct 14, 1993||Nov 26, 1996||Dura Pharmaceuticals, Inc.||Dry powder inhaler|
|US5642727 *||Jul 25, 1995||Jul 1, 1997||David Sarnoff Research Center, Inc.||Inhaler apparatus using a tribo-electric charging technique|
|US5669973 *||Jun 6, 1995||Sep 23, 1997||David Sarnoff Research Center, Inc.||Apparatus for electrostatically depositing and retaining materials upon a substrate|
|US5714007 *||Jun 6, 1995||Feb 3, 1998||David Sarnoff Research Center, Inc.||Apparatus for electrostatically depositing a medicament powder upon predefined regions of a substrate|
|US5857456 *||Jun 10, 1996||Jan 12, 1999||Sarnoff Corporation||Inhaler apparatus with an electronic means for enhanced release of dry powders|
|US5871010 *||Jun 10, 1996||Feb 16, 1999||Sarnoff Corporation||Inhaler apparatus with modified surfaces for enhanced release of dry powders|
|US6006747 *||Mar 20, 1997||Dec 28, 1999||Dura Pharmaceuticals, Inc.||Dry powder inhaler|
|US6007630 *||Jun 6, 1996||Dec 28, 1999||David Sarnoff Research Center Inc.||Method and apparatus for electrostatically depositing a medicament powder upon predefined regions of a substrate|
|US6055980 *||Jul 22, 1998||May 2, 2000||Dura Pharmaceuticals, Inc.||Dry powder inhaler|
|US6074688 *||Oct 18, 1996||Jun 13, 2000||Delsys Pharmaceautical Corporation||Method for electrostatically depositing a medicament powder upon predefined regions of a substrate|
|US6102036 *||Jul 30, 1998||Aug 15, 2000||Smoke-Stop||Breath activated inhaler|
|US6116237 *||Apr 24, 1997||Sep 12, 2000||Dura Pharmaceuticals, Inc.||Methods of dry powder inhalation|
|US6142146 *||Jun 12, 1998||Nov 7, 2000||Microdose Technologies, Inc.||Inhalation device|
|US6149774 *||Jun 10, 1998||Nov 21, 2000||Delsys Pharmaceutical Corporation||AC waveforms biasing for bead manipulating chucks|
|US6152130 *||Jun 12, 1998||Nov 28, 2000||Microdose Technologies, Inc.||Inhalation device with acoustic control|
|US6237591||Nov 2, 1998||May 29, 2001||Dura Pharmaceuticals, Inc.||Turbine dry powder inhaler|
|US6319541||Dec 30, 1999||Nov 20, 2001||Delsys Pharmaceutical Corporation||Method and apparatus for electrostatically depositing a medicament powder upon predefined regions of a substrate|
|US6475351||Jan 30, 2001||Nov 5, 2002||Delsys Pharmaceutical Corporation||AC waveforms biasing for bead manipulating chucks|
|US6591833||Feb 13, 2001||Jul 15, 2003||Delsys Pharmaceutical Corp.||Inhaler apparatus with modified surfaces for enhanced release of dry powders|
|US6637430||Jun 16, 2000||Oct 28, 2003||Ponwell Enterprises Limited||Respiratory delivery system with power/medicament recharge assembly|
|US6802313||Oct 23, 2001||Oct 12, 2004||Sarnoff Corporation||Method and apparatus for electrostatically depositing a medicament powder upon predefined regions of a substrate|
|US6923979||Apr 27, 1999||Aug 2, 2005||Microdose Technologies, Inc.||Method for depositing particles onto a substrate using an alternating electric field|
|US6983748||Oct 26, 2001||Jan 10, 2006||Orion Corporation||Dry powder inhaler|
|US7080644||Jun 25, 2001||Jul 25, 2006||Microdose Technologies, Inc.||Packaging and delivery of pharmaceuticals and drugs|
|US7090830||Nov 20, 2003||Aug 15, 2006||Alexza Pharmaceuticals, Inc.||Drug condensation aerosols and kits|
|US7318434||Feb 17, 2005||Jan 15, 2008||Microdose Technologies, Inc.||Synthetic jet based medicament delivery method and apparatus|
|US7334577||Mar 1, 2006||Feb 26, 2008||Microdose Technologies, Inc.||Synthetic jet based medicament delivery method and apparatus|
|US7458374||May 13, 2002||Dec 2, 2008||Alexza Pharmaceuticals, Inc.||Method and apparatus for vaporizing a compound|
|US7537009||May 13, 2002||May 26, 2009||Alexza Pharmaceuticals, Inc.||Method of forming an aerosol for inhalation delivery|
|US7540286||Jun 3, 2004||Jun 2, 2009||Alexza Pharmaceuticals, Inc.||Multiple dose condensation aerosol devices and methods of forming condensation aerosols|
|US7581540||Aug 12, 2004||Sep 1, 2009||Alexza Pharmaceuticals, Inc.||Aerosol drug delivery device incorporating percussively activated heat packages|
|US7585493||Aug 4, 2003||Sep 8, 2009||Alexza Pharmaceuticals, Inc.||Thin-film drug delivery article and method of use|
|US7632533||Jul 19, 2007||Dec 15, 2009||Microdose Therapeutx, Inc.||Method and apparatus for producing uniform small portions of fine powders and articles thereof|
|US7645442||Aug 4, 2003||Jan 12, 2010||Alexza Pharmaceuticals, Inc.||Rapid-heating drug delivery article and method of use|
|US7766013||Aug 3, 2010||Alexza Pharmaceuticals, Inc.||Aerosol generating method and device|
|US7779837||Dec 6, 2007||Aug 24, 2010||Microdose Therapeutx, Inc.||Synthetic jet based medicament delivery method and apparatus|
|US7784459 *||Sep 11, 2008||Aug 31, 2010||Robert Abrams||Semi-automatic emergency medication dose nebulizer|
|US7810495||Jun 19, 2006||Oct 12, 2010||Microdose Therapeutx, Inc.||Packaging and delivery of pharmaceuticals and drugs|
|US7814902||Jan 26, 2009||Oct 19, 2010||Robert Abrams||Semi-automatic emergency medication dose nebulizer|
|US7834295||Sep 16, 2008||Nov 16, 2010||Alexza Pharmaceuticals, Inc.||Printable igniters|
|US7836885||Jul 3, 2008||Nov 23, 2010||Robert Abrams||Semi-automatic emergency medication dose nebulizer|
|US7913688||May 20, 2003||Mar 29, 2011||Alexza Pharmaceuticals, Inc.||Inhalation device for producing a drug aerosol|
|US7942147||May 17, 2011||Alexza Pharmaceuticals, Inc.||Aerosol forming device for use in inhalation therapy|
|US7950390||Aug 25, 2009||May 31, 2011||Microdose Therapeutx, Inc.||Packaging and delivery of pharmaceuticals and drugs|
|US7981401||Feb 2, 2007||Jul 19, 2011||Alexza Pharmaceuticals, Inc.||Diuretic aerosols and methods of making and using them|
|US7987846||Nov 21, 2008||Aug 2, 2011||Alexza Pharmaceuticals, Inc.||Method and apparatus for vaporizing a compound|
|US8015969||Apr 13, 2010||Sep 13, 2011||Robert Abrams||Semi-automatic emergency medication dose nebulizer|
|US8074644||Dec 13, 2011||Alexza Pharmaceuticals, Inc.||Method of forming an aerosol for inhalation delivery|
|US8235037||Aug 7, 2012||Alexza Pharmaceuticals, Inc.||Drug condensation aerosols and kits|
|US8291902||Jun 30, 2011||Oct 23, 2012||Robert Abrams||Enhanced semi-automatic emergency medication dose nebulizer|
|US8322338||May 7, 2010||Dec 4, 2012||Microdose Therapeutx, Inc.||Synthetic jet based medicament delivery method and apparatus|
|US8333197||Dec 18, 2012||Alexza Pharmaceuticals, Inc.||Multiple dose condensation aerosol devices and methods of forming condensation aerosols|
|US8371294||Feb 25, 2009||Feb 12, 2013||Microdose Therapeutx, Inc.||Method and apparatus for driving a transducer of an inhalation device|
|US8387612||Jun 16, 2009||Mar 5, 2013||Alexza Pharmaceuticals, Inc.||Self-contained heating unit and drug-supply unit employing same|
|US8439033||Oct 6, 2008||May 14, 2013||Microdose Therapeutx, Inc.||Inhalation device|
|US8474452||Feb 23, 2005||Jul 2, 2013||Microdose Therapeutx, Inc.||Directional flow sensor inhaler|
|US8550070||Jun 20, 2002||Oct 8, 2013||Orion Corporation||Powder inhaler|
|US8573202||Aug 17, 2010||Nov 5, 2013||Microdose Therapeutx, Inc.||Packaging and delivery of pharmaceuticals and drugs|
|US8748488||Mar 14, 2013||Jun 10, 2014||Microdose Therapeutx, Inc.||Methods and compositions for administration of oxybutynin|
|US8763606||May 21, 2010||Jul 1, 2014||Microdose Therapeutx, Inc.||Rotary cassette system for dry powder inhaler|
|US8955512||Mar 27, 2013||Feb 17, 2015||Alexza Pharmaceuticals, Inc.||Method of forming an aerosol for inhalation delivery|
|US8985101||Mar 15, 2013||Mar 24, 2015||Microdose Therapeutx, Inc.||Method and device for clamping a blister within a dry powder inhaler|
|US8991387||Mar 4, 2013||Mar 31, 2015||Alexza Pharmaceuticals, Inc.||Self-contained heating unit and drug-supply unit employing same|
|US8991390||Jan 5, 2011||Mar 31, 2015||Microdose Therapeutx, Inc.||Inhalation device and method|
|US9119777||Dec 27, 2012||Sep 1, 2015||Microdose Therapeutx, Inc.||Methods and compositions for administration of oxybutynin|
|US9132246||Apr 9, 2013||Sep 15, 2015||Microdose Therapeutx, Inc.||Inhalation device|
|US9162031||Jun 7, 2013||Oct 20, 2015||Microdose Therapeutx, Inc.||Directional flow sensor inhaler|
|US9180263||Jun 30, 2010||Nov 10, 2015||Microdose Therapeutx, Inc.||Laboratory animal pulmonary dosing device|
|US20030056789 *||Sep 10, 2002||Mar 27, 2003||Omron Corporation||Module of drug particle separator and inhaler provided with same|
|US20040069303 *||Oct 26, 2001||Apr 15, 2004||David Brown||Dry powder inhaler|
|US20050005933 *||Jun 20, 2002||Jan 13, 2005||Kari Seppala||Powder inhaler|
|US20050048003 *||Oct 8, 2004||Mar 3, 2005||Unisia Jecs Corporation||Inhalant medicator|
|US20050158366 *||Mar 16, 2005||Jul 21, 2005||Richard Fotland||Method and apparatus for producing uniform small portions of fine powders and articles thereof|
|US20050172962 *||Feb 3, 2005||Aug 11, 2005||Microdose Technologies, Inc.||Blister pack for use with an inhalation device|
|US20050183725 *||Feb 23, 2005||Aug 25, 2005||Microdose Technologies, Inc.||Directional flow sensor inhaler|
|US20060174869 *||Mar 1, 2006||Aug 10, 2006||Gumaste Anand V||Synthetic jet based medicament delivery method and apparatus|
|US20060237011 *||Jun 19, 2006||Oct 26, 2006||Gumaste Anand V||Packaging and delivery of pharmaceuticals and drugs|
|US20070240712 *||Apr 4, 2007||Oct 18, 2007||Scott Fleming||Variable dose inhalation device|
|US20080014365 *||Jul 19, 2007||Jan 17, 2008||Richard Fotland||Method and apparatus for producing uniform small portions of fine powders and articles thereof|
|US20080163610 *||Jan 5, 2007||Jul 10, 2008||Matthew Thomas Baird||Method and system for regenerating exhaust system filtering and catalyst components using variable high engine idle|
|US20080196717 *||Sep 8, 2005||Aug 21, 2008||Glaxosmithkline Pharmaceuticals S.A.||Powder Inhaler|
|US20090000619 *||Sep 8, 2005||Jan 1, 2009||Glaxosmithkline Pharmaceuticals S.A.||Powder Inhaler, System for Opening and Emptying Capsules|
|US20090071469 *||Sep 11, 2008||Mar 19, 2009||Robert Abrams||Semi-automatic emergency medication dose nebulizer|
|US20090071470 *||Sep 18, 2007||Mar 19, 2009||Robert Abrams||Emergency medication dose nebulizer|
|US20090071473 *||Jul 3, 2008||Mar 19, 2009||Robert Abrams||Semi-automatic emergency medication dose nebulizer|
|US20090090361 *||Oct 6, 2008||Apr 9, 2009||Anand Gumaste||Inhalation device|
|US20090151716 *||Feb 24, 2009||Jun 18, 2009||Robert Abrams||Semi-automatic emergency medication dose nebulizer|
|CN101884821A *||Jun 25, 2010||Nov 17, 2010||天津港保税区佳辰国际贸易有限公司||Anion salt chest|
|EP1941868A2||Feb 26, 2001||Jul 9, 2008||PharmaKodex Limited||Improvements in or relating to the delivery of oral drugs|
|EP2357015A2||Apr 4, 2007||Aug 17, 2011||MicroDose Therapeutx, Inc.||Variable dose inhalation device|
|EP2362796A1 *||Jan 30, 2011||Sep 7, 2011||Aespira Ltd.||Dry powder inhaler|
|WO1994008552A2 *||Oct 12, 1993||Apr 28, 1994||Dura Pharma Inc||Dry powder inhaler|
|WO1998041265A1 *||Mar 16, 1998||Sep 24, 1998||Dura Pharma Inc||Dry powder inhaler|
|WO1999064095A2||Jun 14, 1999||Dec 16, 1999||Microdose Technologies Inc||Metering, packaging and delivery of pharmaceuticals and drugs|
|WO2005081833A2||Feb 17, 2005||Sep 9, 2005||Microdose Technologies Inc||Synthetic jet based medicament delivery method and apparatus|
|WO2007107160A1||Mar 21, 2007||Sep 27, 2007||Bang & Olufsen Medicom As||Inhaler flow channel|
|WO2015143012A1||Mar 18, 2015||Sep 24, 2015||Infinity Pharmaceuticals, Inc.||Heterocyclic compounds for use in the treatment of pi3k-gamma mediated disorders|
|Cooperative Classification||A61M2015/0033, A61M15/0028, A61M2202/064|