|Publication number||US3850161 A|
|Publication date||Nov 26, 1974|
|Filing date||Apr 9, 1973|
|Priority date||Apr 9, 1973|
|Publication number||US 3850161 A, US 3850161A, US-A-3850161, US3850161 A, US3850161A|
|Original Assignee||Liss S|
|Export Citation||BiBTeX, EndNote, RefMan|
|Patent Citations (6), Non-Patent Citations (1), Referenced by (220), Classifications (7)|
|External Links: USPTO, USPTO Assignment, Espacenet|
United States Patent [1 1 Liss [ Nov. 26, 1974 METHOD AND APPARATUS FOR MONITORING AND COUNTERACTING EXCESS BRAIN ELECTRICAL ENERGY TO PREVENT EPILEPTIC SEIZURES AND THE LIKE  Inventor: Saul Liss, 555 E. 27th St., Paterson,
 Filed: Apr. 9, 1973  Appl. No.: 348,864
 US. Cl 128/2.1 R, 128/419 S, 128/422  Int. Cl. A61b 5/04, A61n 1/00  Field of Search 128/2.l R, 2.1 B, 2.1 P,
l28/2.1 Z, 2.06 D, 419 R, 419 S, 422, l C, 410
 References Cited UNITED STATES PATENTS 3,032,029 5/1962 Cunningham l28/2.l R 3,495,596 2/1970 Condict l28/l C 3,510,765 5/1970 Baessler A 128/2.06 A 3,513,834 5/1970 Suzuki et al. .1 l28/2.l 8 3,587,563 6/1971 Ragsdale......... 128/206 A 3,699,970 10/1972 Brindey et a1 128/419 R OTHER PUBLICATIONS John Osmundson, Matador with Radio Stops Wired Bull New York Times Newspaper, pg. 1 8!. 20,
Primary Examiner Richard A. Gaudet Assistant ExaminerLee S. Cohen Attorney, Agent, or FirmRalph R. Roberts  ABSTRACT This invention pertains to a biomedical detecting and control apparatus wherein electrical signals in the brain of mammals are continuously monitored by electrodes implanted in certain critical places in the brain wherein excess electrical energy is manifest during epileptic seizure conditions as well as during psychic storms of some types of mental illness. Such signals are processed via electrical systems of various circuits for inversion, comparison, vector analog addition, filtering, modulation, level set, safety level limits and self test to provide a controlled signal output which automatically reduces or eliminates the excess electrical energy at the point of detection. The points of detection and control may be, but do not have to be, the same spots on the brain. The probes may be near the surface of the brain or deep set in the brain depending upon the area affected. In addition to the method, there is described an electronic device which is contemplated to be housed in a small housing outside the body of the mammal and connected through wire conductors connected to the electrodes at the point of detection and at the other end of the conductors to outlet connectors in the housing providing the point of control.
10 Claims, 3 Drawing Figures 2 26, i 34 7 F1 1 44 i INVERTING I COMPA -x F i i ELECTRONICS g (Ft-x); E 1 MODULATOR SAFETY ADDITION CIRCUIT F'LTER a LEVEL ser 42 emu, AMPLIFIER 22 BRAIN common I I ELECTRODE I i OUTPUT 'I3 R F28 C 46 1 I I I4 0 /I6 l 7 I REFERENC BATTERY I0 LEVEL POWER s51- av SUPPLY OSCILLATOR oocron *H 54 5s 62/)! SELF rssr CIRCUIT WITH :ZZ' H CONTROL LOW LIMIT PATENTEDHUVEBISM 3 5 sum 2 BF 2 TYPICAL POIN T OF DETECTION TYPICAL PomT 6 OF CONTROL METHOD AND APPARATUS FOR MONITORING AND COUNTERACTING EXCESS BRAIN ELECTRICAL ENERGY TO PREVENT EPILEPTIC SEIZURES AND THE LIKE BACKGROUND OF THE INVENTION 1. Field of the Invention With reference to the classification of art as established in the US. Patent Office the present invention pertains to art found in the Class entitled, Surgery (Class 128) and the subclass of pulsating and alternating electric circuits (subclass 421).
2. Description of the Prior Art Many patents are directed toward analysis of and conditions causing mental illness. These studies of mammal brains and the resulting behaviors have confirmed that electrical impulses within the brain cause predicted results in parts of the body associated with specific areas of the brain. Among these patents are US. Pat. No. 3,495,596 to CONDICT as issued on Feb. 17, 1970; U.S. Pat. No. 2,368,207 to EATON as issued on Jan. 30, 1945 and US. Pat. No. 2,473,378 to LIB ERSON as issued on June 14, 1949.
As a result of these studies of mammals, including humans, it has been found that there are certain types of epilepsy and psychic diseases (mental illness) wherein an aura condition exists prior to the happening of an epileptic or psychic storm. During that period of time it has been found that the level of electrical activity rises by a magnitude of 5 to times the normal 10 millivolt level typically found in the average human brain. The frequency of the brain signals change from 5 to 8 herz down to one-half to one herz. During this storm period in particular areas of the brain, the pattern of electrical activity or irregularity can spread to other various spots and areas of the brain much in the way worn electrical insulation may give way to excess electrical potential causing an electrical discharge either locally or in large areas depending on the specific characteristics of insulation and voltage application. Just as electrical systems of extreme precision are protected and controlled by regulators, filters, fuses, etc. so also is it a purpose of this device to counteract automatically any excess electrical energy in the brain at the spots being monitored and detected.
Cases have been reported wherein olfactory senses have been utilized to overcome the aura effect and by this means prevent the consequential seizure. This has produced a belief that, at least in some cases, the electrical energy in the brain indicated by such reaction can be duplicated under controlled conditions and can be used to control a brain center other than at the place at which the excessive aberrant energy is resent. Hence, the method and present. of this invention contemplates conditions where implanted electrodes for detection and control may be placed in selected parts of the brain not directly involved with the excessive pattern.
Temporal lobe epilepsy is a typical disease where it is believed to be necessary to provide deep implanted electrodes; first of all to detect the electrical presence of the aberrant energy and second of all to counteract locally this excessive aberrant energy. The method and apparatus of this invention is intended to provide the detection means and the electrical signals necessary to counteract and restrain these excesses.
SUMMARY OF THE INVENTION This invention may be summarized at least in part with reference to its objects. It is an object of this invention to provide both the method and the means of monitoring the brain of a mammal by means of permanently inserted electrodes in selected critical areas of the brain. By connecting these electrodes to a monitoring device, safety limits for brain signal outputs can be evaluated and upon indications of excess outputs counteracting signals can be fed to the brain to prevent aberrant activity as produced in certain mental illness conditions and epilepsy seizures.
In addition to the above summary the following disclosure is detailed to insure adequacy and aid in understanding of the invention. This disclosure, however, is not intended to prejudice that purpose of a patent which is to cover each new inventive concept therein no matter how it may later be disguised by variations,
in form or additions of further improvements. For this reason there has been chosen a specific circuit diagram showing a means of employing the signals within a brain of a mammal and by monitoring and counteracting excessive energy showing a preferred means for preventing these excesses. This specific embodiment has been chosen for the purposes of illustration and description as shown in the accompanying drawings wherein:
BRIEF DESCRIPTION OF THE DRAWINGS FIG. 3 represents a diagram showing the attachment of and the support of the apparatus to and by a human.
In the following description and in the claims various details will be identified by specific names for convenience, these names, however, are intended to be generic in their application. Corresponding reference characters refer to like members throughout the three figures of the drawings.
The drawings accompanying, and forming part of, this specification disclose certain details for the purpose of explanation of the broader aspects of the invention, but it should be understood that details may be modified without departure from the concept of the invention and that the invention may be incorporated in other structural forms than shown.
PRINCIPLE OF OPERATION AS, SEEN IN THE ASSOCIATED BLCXIK DIAGRAM In the skull or head 10 of the mammal a common electrode 12 is placed into the frontal bone or other zero level activity point from which to detect levels of normal and abnormal electrical energy created in the brain. This electrode is connected by a conductor 13 to an electronic circuit.
The second detecting electrode 14 is placed into one of the critical brain areas such as the eleptogenic lesion portions of the skull 10, while a third electrode 16 is placed into a control point of the brain. This may be in the same area as the detecting electrode or a different area of the brain.
Signals from electrode 14 are fed through a conductor 20 to an inverting electronic device 22 which changes the electrical phase of the detected signal in preparation for use by a comparison circuit 24. The signal from the inverter 22 is fed to the comparison circuit through a conductor 26.
A reference voltage level R, which typically may be about millivolts in the case of a human, is set by the doctor in charge who has determined by appropriate tests the level of voltage in the brain beyond which the patient to which the device is affixed needs a countermotive force brought to action to quell the ensuing anticipated storm. This reference voltage after the level has been established is set and then is fed to the comparison circuit 24 through a conductor 28.
The comparison and analog addition circuit 24 will perform a vector addition so that the resultant R-X should be a quantity negative in phase to that of the original detected value X from electrode 14. The resultant is such that X+( R-X) equals the value R, the normal set level. However, it may be found that the point of control as compared to the point of detection may be scale factors apart. When this occurs a level set amplifier provides compensation for such a condition.
Between the output from comparison circuit 24 which is fed to amplifier 30 is a filter 32 which receives the outputKR-X) from circuit 24 as fed through conductor 34. This filter 32 is used to prevent the electronics of the brain analysis from interfering with other electrical functions such as heart beat and respiration. An oscillator 40 is adapted to generate a high frequency signal which signal is used as a carrier for the feedback information being communicated to the brain point of control.
Since the synaptic chains (in the brain) have the manifestation of semiconductors in that they act as diode detectors as in a radio circuit the information provided to the snyaptic circuits is oriented in such a manner that the normal operation of the nervous system will now detect the control data at minimum energy level to accomplish the needed reduction of the brain energy at the localized areas and provide an elimination of the excess electrical energy in the brain.
Signals from the modulator 30 are sent through conductor 42 to a safety limit circuit 44 which provides standby passive and active networks which act as a limiting fuse to insure and prevent any excessive energy from the said electrical apparatus to be fed to the brain to cause or affect the brain or other nervous system. Signals from the circuit44 to electrode 16 is carried by conductor 46. A battery power supply 50 energizes the circuit and because of the serious nature of this control device and what a deficiency in energization would cause preferably includes a self test circuit with a low limit control 54 and an alarm 56 for extra protection.
Referring next to FIG. 3, there is depicted the normal arrangement and mounting of the apparatus on the patient. The electrodes 12, I4 and 16 are implanted in the brain in the skull 10 of the patient 60 to be treated and controlled. Conductors 13, 20 and 46 carry the signals and controlling voltage to the electronic circuits carried in a small case 62. The components carried by the case are enclosed in phantom outline in FIG. 1. Except for the-battery power which is contemplated to be a small battery, the circuits providing the inverter 22, the
comparison and analog addition 24, filter 32, modulator 30, safety circuit 44, oscillator 40 and self test circuit 54 are all contemplated to be solid state minaturized as much as possible. The reference voltage set is usually an adjustable resistor located within the case and set by key means to prevent an accidental change. It is contemplated that the case 62 when used externally is less than the size of a package of cigarettes. With integrated circuitry the case 62 may be made even smaller for implanting under the skin of the patient 60.
USE AND OPERATION Automatic feedback control is the essence of this invention in that this control receives signals indicating aberrant energy from the brain, analyses it electronically as necessary and with a proper safety and power supply means then feeds electric energy back into the brain in opposition to the original aberrant level so that the net resultant voltage, current and/or electrical field in localized areas on the brain is maintained at no level greater than that experienced during normal behavior. The electronicfeedback device of this invention is applied not only to those types of epilepsy where aura is electrically seen prior to an actual seizure (typified by some types of Grand Mal and Temporal Lobe Epilepsy) but also is applied to some types of mental illness where psychic storms occur providing electrical activity in the brain similar to that of epilepsy but having as its manifestations psychic storms instead of physiological seizures.
The means of detecting and controlling the voltage level of the brain is through the use of implanted electrodes 12, 14 and 16. The reason for employing implanted electrodes as compared to surface electrodes is to provide the exact point of application in the brain where either the point of detection or the point of control can be found without having the electrical path through the skull either deterioriate the signal in terms of the detection signal due to the impedance of the fluids, tissue, skull bone and other media between such point of detection and an external point. Similarly, a control signal for feedback data, if applied externally, would require a larger electrical signal to produce a comparable control. Typical electrical voltages repre sented in medical research studies reveal that when monitored internally a normal brain pattern signal can reach 10 millivolts while the same signal monitored outside the skull produces a level of approximately 10 microvolts.
The aura condition of an epileptic seizure can in fact increase the electrical activity a factor of 10 times to a level 100 millivolts (when monitored internally). Hence, for a corrective signal to be applied in opposition to such an aberrant level, a minus millivolts level would be internally applied whereas approximately minus 90 volts would be externally applied; a quantity which could be dangerous. Therefore, in the present invention internal electrodes are to be used so that the voltage control will be at low levels which is safe.
The concept of automatic feedback has been used in the field of servo technology for many years. The uniqueness of the present invention is the application of automatic feedback theory and devices wherein the electrical energy of a mammal such as a'human is considered part of a servo loop in the automatic feedback.
The normalizing of this current flow provides a resultant improvement in the mammals performance where without such feedback control afflictions such as epilepsy and mental illness prevent the normal behavior of that particular mammal and the resulting deterioration caused by the affliction.
The employment of this system requires implanted electrodes, transdermal wires and external electronics. It is noted that just as history with heart pacemakers has shown that totally implanted devices can be made practical, so also is it anticipated that this device with sufiicient experience and history will be implanted with the application of electronic miniaturization. The miniature electronic detection and control device of this invention will be capable of being totally implanted thus eliminating transdermal wire with the inherent possibility of damage and failure of the system.
In use, detected signal from electrode 14 is carried by conductor 20 to an inverting circuit 22 where the signal is reversed in polarity (minus the reference voltage level) in order to be added to the aberrant brain electrical level during the epileptic or psychic storms. This causes the brain voltage to be reduced to that of the reference level. This action is similar to that of adding several voltages together in an analog computer at a summing junction where the resultant electrical levels are the algebraic sum of all voltages added at that point. This, of course, takes into consideration the sign or phase of the voltages being added.
The common or ground electrode 12 is used as a reference point against which the electrical levels at the point of detection, the point of control and all other computing reference and safety electrical levels is judged and conditioned.
The inverted signal X from circuit 22 is carried by conductor 26 to the comparison and analog addition circuit 24. Also to electronic circuit 24 is fed signal R which is carried by conductor 28 and is the reference voltage level set by the doctor. Another signal is the brain signal from the common electrode 12 which is fed to this comparison circuit. Direct current power to operate the electronic circuitry is derived from the power supply 50 which has its own related safety and self-test circuitry 54 which when used as a permanently installed unit includes a low limit alarm 56 which indicates when a malfunction or voltage loss occurs.
The comparison and analog addition circuitry 24 receives the inverted signal X from conductor 26 and combines this algebraically with signal R carried by conductor 28 so that the electrical quantity R-X is produced as a raw signal yet to be conditioned for use as the ultimate feedback signal. This raw signal is fed by conductor 34 to the filter 32 which removes all frequency components which could effect vital functions such as respiration and heart action. The frequency band usable for these functions is approximately 5 to 40 herz. The signal entering the modulation and level set amplifier 30 is the electrical quantity R-X limited within the frequencies of F to F2 (approximately 5 to herz).
The oscillator 40 and modulator level set amplifier 30 are both operated from the same battery power supply 50, noted above.
The oscillator generates a high frequency carrier signal wherein there is created a selected frequency having a range from 40,000 herz to 1 million herz. The need to use a high frequency carrier is so as to utilize 6 the lowest voltage possible in the carrier electrical signals and also to utilize the inherent electrical phenomenon manifest in the synapsis of the brain. Since the electrical nerve pathways in the body are-really c0mposed of synapsis which react to provide electrical energy transfer similar to the semiconductor devices called diodes the operator of the device is able to forecast the utilization of these synaptic pathways as diode detectors. This means that the diode characteristic which is used in radio circuits to separate the audio information from the high frequency carrier signal is like the present circuit of this invention where it is planned to use the conditioned feedback signal to detect and provide for brain control utilizing the brain synapsis. The brain synapsis is emloyed to demodulate the correct data from the high frequency carrier which by itself is not seen by the rest of the body. The level set amplifier, 30 is set by the doctor so that the particular mammal being treated has the determined electrical levels set to compensate for the particular levels required to stablize the brain activity of that mammal. If the control signal is fed back into the same area from which the electrode received signals are set, the voltage is likely to be at unity value with respect to the originating signal. However, when it is necessary to apply the control signal at a point of control which is different from the point of detection by the electrodes it will be required to use a ratio scale to increase or decrease the control signal experimentally to determine that signal level necessary at the point of control which is required to quell or stabilize the detected aberrant energy in the brain.
The modulator 30 receives the high frequency signal generated by the oscillator 40 and impinges on the signal the envelope of frequencies entering the modulator and level set amplifier 30. These frequencies include the electrical signal quantity R-X filtered from F1 to F2 by filter 32 which modulates in amplitude the high frequency signal. The resulting conditioned electrical signal is sent by conductor 42 to the safety limit circuit 44.
This safety limit circuit 44 provides additional electrical safeguards to prevent either momentary or long term pulses or continuous electrical signals from developing to a level which will be injurious to the mammal involved. As the time constant of energy of the physiological mammal is in terms of milliseconds and the electrical condition and functioning of the control circuit is in terms of microseconds, the electronic circuit acts at a rate which is responsive and available to assist the physiological needs of the mammal.
Self-test circuit 54 is designed to assure the mammal, when human, to which this device is connected that the electronic circuit is in an operative condition ready for activiation without any jeopardy of the operation arising from low battery voltage.
It is anticipated, as above noted, that the initial electronics and power source (battery and control safety circuits) will occupy a volume less than a pack of standard cigarettes and be externally carried on the user. With the use of micro electronics it is further anticipated that this size can ultimately be further reduced and the electronics and power source be mounted beneath the skin surface of the user in the form of a small wafer.
Terms such as left," right, up, down," bottom," top, front, back, in, out and the like are applicable to the embodiment shown and described in conjunction with the drawings. These terms are merely for the purpose of description and do not necessarily apply to the position in which the apparatus for monitoring and counteracting excess brain energy may be constructed or used.
While this particular embodiment of the apparatus and method of use has been shown and described it is to be'understood the invention is not limited thereto since modifications may be made within the scope of the accompanying claims and protection is sought to the broadest extent the prior art allows.
What is claimed is:
1. Apparatus for monitoring, analyzing and when required counteracting excess brain electrical energy of a patient to prevent epileptic seizures and the like, said apparatus including: (a) three electrodes adapted to be implanted in the brain being monitored, each electrode connected through conductors to a constantly ener gized and connected electronic circuit, said electrodes including a first implantable electrode adapted to be placed in a zero activity point of the brain, the electrical output from this first electrode detecting the levels of normal and abnormal electrical energy and feeding this output as a signal to the electronics circuit portion of the apparatus, a second implantable electrode adapted to be placed in a typical point of detection area of the brain, the output from this electrode sent as a signal from this area to the electronic circuit, and a third implantable electrode adapted to be placed in a typical point of control of the same brain, this electrode receiving countermotive forces from the electronic circuit when said circuit so determines; (b) an electronic means and an amplifier means in said electronic circuit, said electronic means receiving the output of the implantable second electrode and inverting this output after which the resulting electrical signal is fed to said amplifier means of the electronic circuit, said amplifier means providing a comparison and addition means to incoming signals; (c) a conductor connected to the first electrode, said conductor being connected to said amplifier means and carrying the electrical energy level of the zero activity portion of the brain to the amplifier which analyzes and compares this energy level in rela tion to previously established normal; (d) means for sending a reference voltage to the amplifier comparison and addition circuit, this reference voltage established and set by the operator in accordance to previously determined electrical thresholds of the brain of the patient in which the electrodes are to be implanted, this reference voltage being compared by and in said amplifier circuit and where necessary a vector addition is made by this amplifier circuit to add voltage to the inverted received voltage; (e) a circuit means in the electronic circuit for receiving and monitoring the signal from the comparison and addition circuit means and when this signal exceeds a set level amplifies this signal a determined amount; (f) a circuit means providing both passive and active electronic network means for receiving the monitored and amplified signal indicative of excess energy outputs from the second electrode and within predetermined maximum limits provides a countermotive force which is sent through a conductor to the third electrode which force quells this storm in the brain, and (g) a power means connected to the electrical circuit to supply a constantly on" power necessary to energize the electrical circuit to normal operating levels.
2. Apparatus for monitoring and counteracting excess brain electrical energy as in claim 1 in which the power means is a battery whose energy level is monitored by a self .test circuit means and there is additionally circuit means connected to said power means providing a limit control and an alarm which is actuated when the voltage drops below that set by the limit control.
3. Apparatus for monitoring and counteracting excess brain electrical energy as in claim 2 in which there is provided an oscillator which generates a high frequency signal connected to the circuit means for receiving and monitoring the signal from the comparison and addition circuit, this high frequency signal being used as a carrier for a feedback signal when such a signal is sent to the third electrode.
4. Apparatus for monitoring and counteracting excess brain electrical energy as in claim 3 in which the electronic circuit includes a filter connected between said comparison and analog addition means and said circuit means for receiving and monitoring the signal from the comparison and analog addition means which receives the signal output from electronic circuit means providing the comparison and analog addition function and filters the electronic flow to prevent this flow from interfering with other electrical brain functions such as heart beat and respiration, said filtered signal being conducted and fed to the circuit means for receiving and monitoring the signal from the comparison and addition circuit means.
5. Apparatus for monitoring and counteracting excess brain electrical energy as in claim 4 in which the electrodes are adapted to be permanently implanted and the electronics and battery therefore are encased so as to provide a small size unit which may be easily carried on and by the body of the one being monitored.
6. A method for monitoring and counteracting excess brain electrical energy to prevent epileptic seizures which includes the steps of: (a) implanting three electrodes in the brain of the mammal being monitored, the first electrode being placed in a zero activity point of the brain and from this electrode feeding its electrical output to a constantly energized and connected electronic circuit, the second electrode being placed in a typical point of detection area of the brain and a third electrode being placed in a typical point of control of the same brain; (b) connecting the electronic circuit to the second electrode by a conductor and inverting electronically the output of the brain from this second electrode and feeding the resulting inverted signal to an electronic means in said circuit to provide a comparison and addition means to incoming signals; (0) connecting a conductor to the first electrode which carries the electrical energy level of the zero activity in the brain, this electrical energy being fed to the comparison circuit for analysis of the energy in relation to a normal energy level; (cl) setting by the one in charge of the apparatus a reference voltage control level, this reference voltage being fed to the electronic means providing the comparison, said means performing vector addition when necessary; (e) feeding the output signal current of the addition means to a level set amplifier portion of the electronic circuit, which, when necessary, amplifies this current signal; (f) sending the signal cess brain electrical energy as in claim 6 in which the step of providing the power means is a battery whose energy level is monitored by a self-test circuit having a low voltage limit control and an alarm.
8. The method for monitoring and counteracting excess brain electrical energy as in claim 7 which includes the further step of connecting an oscillator which generates a high frequency signal so as to feed said oscillating signal to the level set amplifier portion of the electronic circuit with this high frequency signal'providing a carrier for the feedback signal to the third electrode.
9. The method for monitoring and counteracting excess brain electrical energy as in claim 8 which includes the step of providing a filter which receives the signal output from the electronic means providing the comparison and analog addition and filters the electronic current therefrom to prevent this current signal from interfering with other electrical brain functions such as the heart beat and respiration and feeding said filtered signal to the level set amplifier portion of the electronic circuit.
10. The method for monitoring and counteracting excess brain electrical energy as in claim 9 which includes permanently implanting the electrodes and further includes encasing the electronics and battery to provide a small unit which may be easily carried on the body of the one monitored.
|Cited Patent||Filing date||Publication date||Applicant||Title|
|US3032029 *||Jul 9, 1958||May 1, 1962||Thompson Ramo Wooldridge Inc||System controlling apparatus and method|
|US3495596 *||Mar 23, 1965||Feb 17, 1970||Medel Corp||Apparatus for and method of processing a bioelectrical signal|
|US3510765 *||Jul 31, 1967||May 5, 1970||Humetrics Corp||Method and apparatus for gating variably recurrent waveforms|
|US3513834 *||Nov 21, 1967||May 26, 1970||Hitachi Ltd||Anesthetic depth measuring system|
|US3587563 *||Jan 8, 1969||Jun 28, 1971||Us Army||Heartbeat monitor|
|US3699970 *||Jun 23, 1970||Oct 24, 1972||Nat Res Dev||Striate cortex stimulator|
|1||*||John Osmundson, Matador with Radio Stops Wired Bull New York Times Newspaper, pg. 1 & 20, 5 17 65.|
|Citing Patent||Filing date||Publication date||Applicant||Title|
|US3888260 *||Apr 26, 1974||Jun 10, 1975||Univ Johns Hopkins||Rechargeable demand inhibited cardiac pacer and tissue stimulator|
|US3993046 *||Nov 6, 1974||Nov 23, 1976||Heriberto Fernandez||Seizure suppression device|
|US4165750 *||Mar 9, 1978||Aug 28, 1979||Aleev Leonid S||Bioelectrically controlled electric stimulator of human muscles|
|US4230125 *||Jul 9, 1979||Oct 28, 1980||Schneider Daniel E||Method and apparatus for effecting the prospective forewarning diagnosis of sudden brain death and heart death and other brain-heart-body growth maladies such as schizophrenia and cancer and the like|
|US4440160 *||Jan 19, 1982||Apr 3, 1984||The Johns Hopkins University||Self-injurious behavior inhibiting system|
|US4524773 *||Aug 24, 1983||Jun 25, 1985||The John Hopkins University||Apparatus for inhibiting self-injurious behavior (SIB) in patients|
|US4554928 *||Sep 16, 1983||Nov 26, 1985||Webster Wilton W Jr||Electrophysiological switching unit|
|US4702254 *||Dec 30, 1985||Oct 27, 1987||Jacob Zabara||Neurocybernetic prosthesis|
|US4709700 *||Mar 11, 1985||Dec 1, 1987||Vaclav Hyrman||Electro convulsive therapy method|
|US4867164 *||Oct 26, 1987||Sep 19, 1989||Jacob Zabara||Neurocybernetic prosthesis|
|US4883057 *||Sep 9, 1986||Nov 28, 1989||Research Foundation, The City University Of New York||Cathodic electrochemical current arrangement with telemetric application|
|US5025807 *||Jan 25, 1989||Jun 25, 1991||Jacob Zabara||Neurocybernetic prosthesis|
|US5167229 *||Mar 24, 1986||Dec 1, 1992||Case Western Reserve University||Functional neuromuscular stimulation system|
|US5299569 *||May 3, 1991||Apr 5, 1994||Cyberonics, Inc.||Treatment of neuropsychiatric disorders by nerve stimulation|
|US5311876 *||Nov 18, 1992||May 17, 1994||The Johns Hopkins University||Automatic detection of seizures using electroencephalographic signals|
|US5349962 *||Nov 30, 1993||Sep 27, 1994||University Of Washington||Method and apparatus for detecting epileptic seizures|
|US5443710 *||Nov 18, 1992||Aug 22, 1995||Research Foundation, The City University Of New York||Microelectrodes and their use in a cathodic electrochemical current arrangement with telemetric application|
|US5522863 *||Aug 19, 1994||Jun 4, 1996||The United States Of America As Represented By The Secretary Of The Navy||Pulsating behavior monitoring and modification system for neural networks|
|US5559498 *||Dec 30, 1994||Sep 24, 1996||Innotek Inc.||Combination confinement and remote training system|
|US5609617 *||Feb 21, 1995||Mar 11, 1997||C. Norman Shealy||Method for enhancement of dehydroepiandrosterone|
|US5683422 *||Apr 25, 1996||Nov 4, 1997||Medtronic, Inc.||Method and apparatus for treating neurodegenerative disorders by electrical brain stimulation|
|US5690681 *||Mar 29, 1996||Nov 25, 1997||Purdue Research Foundation||Method and apparatus using vagal stimulation for control of ventricular rate during atrial fibrillation|
|US5700282 *||Oct 13, 1995||Dec 23, 1997||Zabara; Jacob||Heart rhythm stabilization using a neurocybernetic prosthesis|
|US5707396 *||Apr 25, 1996||Jan 13, 1998||Institute National De La Sante De La Recherche Medicale (Inserm)||Method of arresting degeneration of the substantia nigra by high frequency stimulation of subthalamic nucleus|
|US5713922 *||Apr 25, 1996||Feb 3, 1998||Medtronic, Inc.||Techniques for adjusting the locus of excitation of neural tissue in the spinal cord or brain|
|US5713923 *||May 13, 1996||Feb 3, 1998||Medtronic, Inc.||Techniques for treating epilepsy by brain stimulation and drug infusion|
|US5716377 *||Apr 25, 1996||Feb 10, 1998||Medtronic, Inc.||Method of treating movement disorders by brain stimulation|
|US5743854 *||Mar 29, 1994||Apr 28, 1998||The Regents Of The University Of California||Method and apparatus for inducing and localizing epileptiform activity|
|US5752979 *||Nov 1, 1996||May 19, 1998||Medtronic, Inc.||Method of controlling epilepsy by brain stimulation|
|US5792186 *||Apr 30, 1997||Aug 11, 1998||Medtronic, Inc.||Method and apparatus for treating neurodegenerative disorders by electrical brain stimulation|
|US5797965 *||Mar 26, 1997||Aug 25, 1998||The United States Of America As Represented By The Secretary Of The Navy||Suppression of epileptiform activity|
|US5800474 *||Nov 1, 1996||Sep 1, 1998||Medtronic, Inc.||Method of controlling epilepsy by brain stimulation|
|US5814092 *||May 8, 1997||Sep 29, 1998||Medtronic Inc.||Neural stimulation techniques with feedback|
|US5833709 *||Apr 30, 1997||Nov 10, 1998||Medtronic, Inc.||Method of treating movement disorders by brain stimulation|
|US5913882 *||Jun 5, 1998||Jun 22, 1999||Medtronic Inc.||Neural stimulation techniques with feedback|
|US5916239 *||Nov 24, 1997||Jun 29, 1999||Purdue Research Foundation||Method and apparatus using vagal stimulation for control of ventricular rate during atrial fibrillation|
|US5938689 *||May 1, 1998||Aug 17, 1999||Neuropace, Inc.||Electrode configuration for a brain neuropacemaker|
|US5954758 *||Jan 20, 1998||Sep 21, 1999||Case Western Reserve University||Functional neuromuscular stimulation system|
|US5975085 *||May 1, 1997||Nov 2, 1999||Medtronic, Inc.||Method of treating schizophrenia by brain stimulation and drug infusion|
|US5995868 *||Jan 6, 1997||Nov 30, 1999||University Of Kansas||System for the prediction, rapid detection, warning, prevention, or control of changes in activity states in the brain of a subject|
|US6006124 *||May 1, 1998||Dec 21, 1999||Neuropace, Inc.||Means and method for the placement of brain electrodes|
|US6018682 *||Apr 30, 1998||Jan 25, 2000||Medtronic, Inc.||Implantable seizure warning system|
|US6023642 *||May 8, 1997||Feb 8, 2000||Biogenics Ii, Llc||Compact transcutaneous electrical nerve stimulator|
|US6026328 *||Jan 20, 1998||Feb 15, 2000||Case Western Reserve University||Functional neuromuscular stimulation system with shielded percutaneous interface|
|US6066163 *||Feb 2, 1996||May 23, 2000||John; Michael Sasha||Adaptive brain stimulation method and system|
|US6128537 *||May 1, 1997||Oct 3, 2000||Medtronic, Inc||Techniques for treating anxiety by brain stimulation and drug infusion|
|US6161044 *||Nov 23, 1998||Dec 12, 2000||Synaptic Corporation||Method and apparatus for treating chronic pain syndromes, tremor, dementia and related disorders and for inducing electroanesthesia using high frequency, high intensity transcutaneous electrical nerve stimulation|
|US6161045 *||Jun 1, 1999||Dec 12, 2000||Neuropace, Inc.||Method for determining stimulation parameters for the treatment of epileptic seizures|
|US6163725 *||Jan 20, 1998||Dec 19, 2000||Case Western Reserve University||Functional neuromuscular stimulation system|
|US6227203||Sep 9, 1998||May 8, 2001||Medtronic, Inc.||Techniques for controlling abnormal involuntary movements by brain stimulation and drug infusion|
|US6230049 *||Aug 13, 1999||May 8, 2001||Neuro Pace, Inc.||Integrated system for EEG monitoring and electrical stimulation with a multiplicity of electrodes|
|US6263237||Feb 14, 2000||Jul 17, 2001||Medtronic, Inc.||Techniques for treating anxiety disorders by brain stimulation and drug infusion|
|US6304775||Sep 22, 1999||Oct 16, 2001||Leonidas D. Iasemidis||Seizure warning and prediction|
|US6354299||Jun 30, 2000||Mar 12, 2002||Neuropace, Inc.||Implantable device for patient communication|
|US6366813||Jun 25, 1999||Apr 2, 2002||Dilorenzo Daniel J.||Apparatus and method for closed-loop intracranical stimulation for optimal control of neurological disease|
|US6374140 *||Apr 30, 1998||Apr 16, 2002||Medtronic, Inc.||Method and apparatus for treating seizure disorders by stimulating the olfactory senses|
|US6459936 *||Aug 17, 2001||Oct 1, 2002||Neuropace, Inc.||Methods for responsively treating neurological disorders|
|US6463328 *||Jan 10, 2000||Oct 8, 2002||Michael Sasha John||Adaptive brain stimulation method and system|
|US6549804||Jun 10, 1999||Apr 15, 2003||University Of Kansas||System for the prediction, rapid detection, warning, prevention or control of changes in activity states in the brain of a subject|
|US6594524||Dec 12, 2000||Jul 15, 2003||The Trustees Of The University Of Pennsylvania||Adaptive method and apparatus for forecasting and controlling neurological disturbances under a multi-level control|
|US6606521||Jul 9, 2001||Aug 12, 2003||Neuropace, Inc.||Implantable medical lead|
|US6647296 *||Aug 17, 2001||Nov 11, 2003||Neuropace, Inc.||Implantable apparatus for treating neurological disorders|
|US6658287||Aug 24, 1999||Dec 2, 2003||Georgia Tech Research Corporation||Method and apparatus for predicting the onset of seizures based on features derived from signals indicative of brain activity|
|US6665562||Dec 6, 2000||Dec 16, 2003||George Mason University||Adaptive electric field modulation of neural systems|
|US6678548||Oct 20, 2000||Jan 13, 2004||The Trustees Of The University Of Pennsylvania||Unified probabilistic framework for predicting and detecting seizure onsets in the brain and multitherapeutic device|
|US6718210||Oct 23, 2000||Apr 6, 2004||Case Western Reserve University||Functional neuromuscular stimulation system|
|US6725086||Nov 20, 2001||Apr 20, 2004||Draeger Medical Systems, Inc.||Method and system for monitoring sedation, paralysis and neural-integrity|
|US6819956||Nov 11, 2001||Nov 16, 2004||Dilorenzo Daniel J.||Optimal method and apparatus for neural modulation for the treatment of neurological disease, particularly movement disorders|
|US6845271||May 3, 2002||Jan 18, 2005||Neurocontrol Corporation||Treatment of shoulder dysfunction using a percutaneous intramuscular stimulation system|
|US6873872||Oct 11, 2002||Mar 29, 2005||George Mason University||Adaptive electric field modulation of neural systems|
|US6988006||Sep 20, 2002||Jan 17, 2006||Medtronic, Inc.||Technique for adjusting the locus of excitation of electrically excitable tissue|
|US7003352||May 2, 2003||Feb 21, 2006||Advanced Bionics Corporation||Treatment of epilepsy by brain stimulation|
|US7013177||Jul 3, 2002||Mar 14, 2006||Advanced Bionics Corporation||Treatment of pain by brain stimulation|
|US7079977||Oct 15, 2003||Jul 18, 2006||Medtronic, Inc.||Synchronization and calibration of clocks for a medical device and calibrated clock|
|US7146211||Oct 15, 2003||Dec 5, 2006||Medtronic, Inc.||Signal quality monitoring and control for a medical device system|
|US7146218||Feb 4, 2003||Dec 5, 2006||The Trustees Of The University Of Pennsylvania||Adaptive method and apparatus for forecasting and controlling neurological disturbances under a multi-level control|
|US7149572||Oct 15, 2003||Dec 12, 2006||Medtronic, Inc.||Phase shifting of neurological signals in a medical device system|
|US7203548||Jun 20, 2002||Apr 10, 2007||Advanced Bionics Corporation||Cavernous nerve stimulation via unidirectional propagation of action potentials|
|US7209787||Nov 20, 2003||Apr 24, 2007||Bioneuronics Corporation||Apparatus and method for closed-loop intracranial stimulation for optimal control of neurological disease|
|US7212851||Oct 24, 2002||May 1, 2007||Brown University Research Foundation||Microstructured arrays for cortex interaction and related methods of manufacture and use|
|US7231254||Jul 12, 2004||Jun 12, 2007||Bioneuronics Corporation||Closed-loop feedback-driven neuromodulation|
|US7242983||Oct 15, 2003||Jul 10, 2007||Medtronic, Inc.||Channel-selective blanking for a medical device system|
|US7242984||Jan 6, 2004||Jul 10, 2007||Neurovista Corporation||Apparatus and method for closed-loop intracranial stimulation for optimal control of neurological disease|
|US7277758||Apr 5, 2004||Oct 2, 2007||Neurovista Corporation||Methods and systems for predicting future symptomatology in a patient suffering from a neurological or psychiatric disorder|
|US7280867||Oct 15, 2003||Oct 9, 2007||Medtronic, Inc.||Clustering of recorded patient neurological activity to determine length of a neurological event|
|US7280870||Jun 4, 2003||Oct 9, 2007||Brown University Research Foundation||Optically-connected implants and related systems and methods of use|
|US7282030||Oct 15, 2003||Oct 16, 2007||Medtronic, Inc.||Timed delay for redelivery of treatment therapy for a medical device system|
|US7292890 *||Jun 20, 2002||Nov 6, 2007||Advanced Bionics Corporation||Vagus nerve stimulation via unidirectional propagation of action potentials|
|US7299096||Dec 9, 2003||Nov 20, 2007||Northstar Neuroscience, Inc.||System and method for treating Parkinson's Disease and other movement disorders|
|US7321837||Feb 15, 2006||Jan 22, 2008||Medtronic, Inc.||Synchronization and calibration of clocks for a medical device and calibrated clock|
|US7324851||Jun 1, 2004||Jan 29, 2008||Neurovista Corporation||Closed-loop feedback-driven neuromodulation|
|US7333851||Sep 12, 2003||Feb 19, 2008||The Trustees Of The University Of Pennsylvania||Unified probabilistic framework for predicting and detecting seizure onsets in the brain and multitherapeutic device|
|US7353064||Feb 19, 2004||Apr 1, 2008||Northstar Neuroscience, Inc.||Systems and methods for enhancing or optimizing neural stimulation therapy for treating symptoms of movement disorders and/or other neurologic dysfunction|
|US7392079||Mar 16, 2006||Jun 24, 2008||Brown University Research Foundation||Neurological signal decoding|
|US7403820||May 25, 2005||Jul 22, 2008||Neurovista Corporation||Closed-loop feedback-driven neuromodulation|
|US7437196||Jul 18, 2006||Oct 14, 2008||Northstar Neuroscience, Inc.||Systems and methods for selecting stimulation sites and applying treatment, including treatment of symptoms of Parkinson's disease, other movement disorders, and/or drug side effects|
|US7483747||Jul 15, 2005||Jan 27, 2009||Northstar Neuroscience, Inc.||Systems and methods for enhancing or affecting neural stimulation efficiency and/or efficacy|
|US7565199||Dec 9, 2003||Jul 21, 2009||Advanced Neuromodulation Systems, Inc.||Methods for treating and/or collecting information regarding neurological disorders, including language disorders|
|US7565200||Nov 12, 2004||Jul 21, 2009||Advanced Neuromodulation Systems, Inc.||Systems and methods for selecting stimulation sites and applying treatment, including treatment of symptoms of Parkinson's disease, other movement disorders, and/or drug side effects|
|US7601116||May 16, 2006||Oct 13, 2009||Neuropace, Inc.||Low frequency magnetic neurostimulator for the treatment of neurological disorders|
|US7616998||Jul 9, 2004||Nov 10, 2009||Medtronic, Inc.||Electrical stimulation of structures within the brain|
|US7623928||May 2, 2007||Nov 24, 2009||Neurovista Corporation||Controlling a subject's susceptibility to a seizure|
|US7624293||Feb 15, 2006||Nov 24, 2009||Medtronic, Inc.||Synchronization and calibration of clocks for a medical device and calibrated clock|
|US7627383||Mar 15, 2005||Dec 1, 2009||Boston Scientific Neuromodulation Corporation||Implantable stimulator|
|US7630757||Aug 1, 2002||Dec 8, 2009||Flint Hills Scientific Llc||System for the prediction, rapid detection, warning, prevention, or control of changes in activity states in the brain of a subject|
|US7647097||Dec 20, 2004||Jan 12, 2010||Braingate Co., Llc||Transcutaneous implant|
|US7657318||Nov 14, 2005||Feb 2, 2010||Medtronic, Inc.||Technique for adjusting the locus of excitation of electrically excitable tissue|
|US7660631||Apr 22, 2005||Feb 9, 2010||Boston Scientific Neuromodulation Corporation||Methods and systems for electrical and/or drug stimulation as a therapy for erectile dysfunction|
|US7676263||Mar 9, 2010||Neurovista Corporation||Minimally invasive system for selecting patient-specific therapy parameters|
|US7684866||Aug 2, 2004||Mar 23, 2010||Advanced Neuromodulation Systems, Inc.||Apparatus and methods for applying neural stimulation to a patient|
|US7689289||Mar 22, 2006||Mar 30, 2010||Medtronic, Inc.||Technique for adjusting the locus of excitation of electrically excitable tissue with paired pulses|
|US7715919||Oct 15, 2003||May 11, 2010||Medtronic, Inc.||Control of treatment therapy during start-up and during operation of a medical device system|
|US7729758||Nov 30, 2005||Jun 1, 2010||Boston Scientific Neuromodulation Corporation||Magnetically coupled microstimulators|
|US7747325||Sep 28, 2005||Jun 29, 2010||Neurovista Corporation||Systems and methods for monitoring a patient's neurological disease state|
|US7751877||Nov 19, 2004||Jul 6, 2010||Braingate Co., Llc||Neural interface system with embedded id|
|US7756584||Sep 27, 2002||Jul 13, 2010||Advanced Neuromodulation Systems, Inc.||Methods and apparatus for effectuating a lasting change in a neural-function of a patient|
|US7783362||Nov 6, 2007||Aug 24, 2010||Boston Scientific Neuromodulation Corporation||Vagus nerve stimulation via unidirectional propagation of action potentials|
|US7801600||May 26, 2005||Sep 21, 2010||Boston Scientific Neuromodulation Corporation||Controlling charge flow in the electrical stimulation of tissue|
|US7801602||Mar 24, 2006||Sep 21, 2010||Boston Scientific Neuromodulation Corporation||Controlling stimulation parameters of implanted tissue stimulators|
|US7803148||Jun 7, 2007||Sep 28, 2010||Neurosystec Corporation||Flow-induced delivery from a drug mass|
|US7831305||Oct 15, 2002||Nov 9, 2010||Advanced Neuromodulation Systems, Inc.||Neural stimulation system and method responsive to collateral neural activity|
|US7853329||Dec 29, 2006||Dec 14, 2010||Neurovista Corporation||Monitoring efficacy of neural modulation therapy|
|US7860570||Jun 20, 2002||Dec 28, 2010||Boston Scientific Neuromodulation Corporation||Implantable microstimulators and methods for unidirectional propagation of action potentials|
|US7865243||Jan 24, 2006||Jan 4, 2011||Boston Scientific Neuromodulation Corporation||Device and therapy for erectile dysfunction and other sexual dysfunction|
|US7877136||Sep 28, 2007||Jan 25, 2011||Boston Scientific Neuromodulation Corporation||Enhancement of neural signal transmission through damaged neural tissue via hyperpolarizing electrical stimulation current|
|US7881780||Dec 30, 2005||Feb 1, 2011||Braingate Co., Llc||Biological interface system with thresholded configuration|
|US7890177||Jan 24, 2006||Feb 15, 2011||Boston Scientific Neuromodulation Corporation||Device and therapy for erectile dysfunction and other sexual dysfunction|
|US7899539||Sep 28, 2006||Mar 1, 2011||Boston Scientific Neuromodulation Corporation||Cavernous nerve stimulation via unidirectional propagation of action potentials|
|US7901368||Dec 29, 2005||Mar 8, 2011||Braingate Co., Llc||Neurally controlled patient ambulation system|
|US7917206||Nov 7, 2006||Mar 29, 2011||Medtronic, Inc.||Signal quality monitoring and control for a medical device system|
|US7930035||May 2, 2007||Apr 19, 2011||Neurovista Corporation||Providing output indicative of subject's disease state|
|US7933646||Aug 13, 2007||Apr 26, 2011||Medtronic, Inc.||Clustering of recorded patient neurological activity to determine length of a neurological event|
|US7966073 *||May 16, 2006||Jun 21, 2011||Neuropace, Inc.||Differential neurostimulation therapy driven by physiological therapy|
|US7970722||Nov 9, 2009||Jun 28, 2011||Aloft Media, Llc||System, method and computer program product for a collaborative decision platform|
|US7974696||Jul 23, 2005||Jul 5, 2011||Dilorenzo Biomedical, Llc||Closed-loop autonomic neuromodulation for optimal control of neurological and metabolic disease|
|US7976465||Oct 17, 2006||Jul 12, 2011||Medtronic, Inc||Phase shifting of neurological signals in a medical device system|
|US7983762||Dec 3, 2008||Jul 19, 2011||Advanced Neuromodulation Systems, Inc.||Systems and methods for enhancing or affecting neural stimulation efficiency and/or efficacy|
|US7991461||Dec 23, 2005||Aug 2, 2011||Braingate Co., Llc||Patient training routine for biological interface system|
|US8005777||Jul 27, 2010||Aug 23, 2011||Aloft Media, Llc||System, method and computer program product for a collaborative decision platform|
|US8036736||Mar 21, 2008||Oct 11, 2011||Neuro Vista Corporation||Implantable systems and methods for identifying a contra-ictal condition in a subject|
|US8060194||Dec 30, 2005||Nov 15, 2011||Braingate Co., Llc||Biological interface system with automated configuration|
|US8065011||Aug 31, 2006||Nov 22, 2011||The Trustees Of The University Of Pennsylvania||Adaptive method and apparatus for forecasting and controlling neurological disturbances under a multi-level control|
|US8065012||Aug 6, 2007||Nov 22, 2011||Advanced Neuromodulation Systems, Inc.||Methods and apparatus for effectuating a lasting change in a neural-function of a patient|
|US8073546||Jul 12, 2010||Dec 6, 2011||Advanced Neuromodulation Systems, Inc.||Methods and apparatus for effectuating a lasting change in a neural-function of a patient|
|US8086294||Aug 13, 2007||Dec 27, 2011||The Trustees Of The University Of Pennsylvania||Unified probabilistic framework for predicting and detecting seizure onsets in the brain and multitherapeutic device|
|US8095209||Dec 27, 2005||Jan 10, 2012||Braingate Co., Llc||Biological interface system with gated control signal|
|US8160988||Jul 27, 2010||Apr 17, 2012||Aloft Media, Llc||System, method and computer program product for a collaborative decision platform|
|US8187181||Oct 15, 2003||May 29, 2012||Medtronic, Inc.||Scoring of sensed neurological signals for use with a medical device system|
|US8224452||May 17, 2011||Jul 17, 2012||Neuropace Inc.||Differential neurostimulation therapy driven by physiological therapy|
|US8249713||Nov 5, 2007||Aug 21, 2012||Spr Therapeutics, Llc||Treatment of shoulder dysfunction using a percutaneous intramuscular stimulation system|
|US8295934||Nov 14, 2006||Oct 23, 2012||Neurovista Corporation||Systems and methods of reducing artifact in neurological stimulation systems|
|US8298176||Jul 19, 2010||Oct 30, 2012||Neurosystec Corporation||Flow-induced delivery from a drug mass|
|US8326431||Apr 28, 2006||Dec 4, 2012||Medtronic, Inc.||Implantable medical device for the concurrent treatment of a plurality of neurological disorders and method therefore|
|US8423145||Jun 14, 2012||Apr 16, 2013||Neuropace, Inc.||Differential neurostimulation therapy driven by physiological therapy|
|US8433415||Apr 18, 2012||Apr 30, 2013||The Trustees Of Dartmouth College||Apparatus and method for modulating neurochemical levels in the brain|
|US8467879||Oct 14, 2005||Jun 18, 2013||Boston Scientific Neuromodulation Corporation||Treatment of pain by brain stimulation|
|US8473060||Dec 30, 2009||Jun 25, 2013||The Trustees Of Dartmouth College||Apparatus and method for modulating neurochemical levels in the brain|
|US8543199||Sep 2, 2011||Sep 24, 2013||Cyberonics, Inc.||Implantable systems and methods for identifying a contra-ictal condition in a subject|
|US8543214||Oct 15, 2003||Sep 24, 2013||Medtronic, Inc.||Configuring and testing treatment therapy parameters for a medical device system|
|US8548604||Dec 6, 2010||Oct 1, 2013||Boston Scientific Neuromodulation Corporation||Implantable microstimulators and methods for unidirectional propagation of action potentials|
|US8560041||Oct 3, 2005||Oct 15, 2013||Braingate Co., Llc||Biological interface system|
|US8560075||Oct 13, 2009||Oct 15, 2013||Alejandro Covalin||Apparatus and method for the treatment of headache|
|US8579786||Oct 15, 2003||Nov 12, 2013||Medtronic, Inc.||Screening techniques for management of a nervous system disorder|
|US8588933||Jan 11, 2010||Nov 19, 2013||Cyberonics, Inc.||Medical lead termination sleeve for implantable medical devices|
|US8594798||Oct 15, 2003||Nov 26, 2013||Medtronic, Inc.||Multi-modal operation of a medical device system|
|US8606361||Jul 8, 2011||Dec 10, 2013||Advanced Neuromodulation Systems, Inc.||Systems and methods for enhancing or affecting neural stimulation efficiency and/or efficacy|
|US8626302||Aug 3, 2009||Jan 7, 2014||Spr Therapeutics, Llc||Systems and methods to place one or more leads in muscle for providing electrical stimulation to treat pain|
|US8712547||Feb 28, 2011||Apr 29, 2014||Boston Scientific Neuromodulation Corporation||Cavernous nerve stimulation via unidirectional propagation of action potentials|
|US8725243||Dec 28, 2005||May 13, 2014||Cyberonics, Inc.||Methods and systems for recommending an appropriate pharmacological treatment to a patient for managing epilepsy and other neurological disorders|
|US8738136||Aug 13, 2007||May 27, 2014||Medtronic, Inc.||Clustering of recorded patient neurological activity to determine length of a neurological event|
|US8762065||Jun 22, 2005||Jun 24, 2014||Cyberonics, Inc.||Closed-loop feedback-driven neuromodulation|
|US8781597||May 5, 2010||Jul 15, 2014||Cyberonics, Inc.||Systems for monitoring a patient's neurological disease state|
|US8786624||Jun 2, 2010||Jul 22, 2014||Cyberonics, Inc.||Processing for multi-channel signals|
|US8812096||Dec 30, 2005||Aug 19, 2014||Braingate Co., Llc||Biological interface system with patient training apparatus|
|US8849390||Dec 29, 2009||Sep 30, 2014||Cyberonics, Inc.||Processing for multi-channel signals|
|US8855775||Oct 23, 2012||Oct 7, 2014||Cyberonics, Inc.||Systems and methods of reducing artifact in neurological stimulation systems|
|US8868172||Dec 28, 2005||Oct 21, 2014||Cyberonics, Inc.||Methods and systems for recommending an appropriate action to a patient for managing epilepsy and other neurological disorders|
|US8929991||Apr 19, 2007||Jan 6, 2015||Advanced Neuromodulation Systems, Inc.||Methods for establishing parameters for neural stimulation, including via performance of working memory tasks, and associated kits|
|US8934980||Mar 4, 2013||Jan 13, 2015||Neuropace, Inc.||Differential neurostimulation therapy driven by physiological therapy|
|US9008780 *||Jun 14, 2012||Apr 14, 2015||Case Western Reserve University||Methods and associated neural prosthetic devices for bridging brain areas to improve function|
|US9033861||Aug 27, 2009||May 19, 2015||Neuropace, Inc.||Low frequency neurostimulator for the treatment of neurological disorders|
|US9042988||Nov 17, 2005||May 26, 2015||Cyberonics, Inc.||Closed-loop vagus nerve stimulation|
|US9044188||May 12, 2014||Jun 2, 2015||Cyberonics, Inc.||Methods and systems for managing epilepsy and other neurological disorders|
|US9050469 *||Nov 24, 2004||Jun 9, 2015||Flint Hills Scientific, Llc||Method and system for logging quantitative seizure information and assessing efficacy of therapy using cardiac signals|
|US9072832||Apr 25, 2014||Jul 7, 2015||Medtronic, Inc.||Clustering of recorded patient neurological activity to determine length of a neurological event|
|US20010051819 *||Aug 17, 2001||Dec 13, 2001||Fischell Robert E.||Implantable apparatus for treating neurological disorders|
|US20040073273 *||Oct 6, 2003||Apr 15, 2004||Gluckman Bruce J.||Adaptive electric field modulation of neural systems|
|US20040082875 *||Oct 24, 2002||Apr 29, 2004||Brown University Research Foundation||Microstructured arrays for cortex interaction and related methods of manufacture and use|
|US20040133120 *||Oct 15, 2003||Jul 8, 2004||Medtronic, Inc.||Phase shifting of neurological signals in a medical device system|
|US20040133248 *||Oct 15, 2003||Jul 8, 2004||Medtronic, Inc.||Channel-selective blanking for a medical device system|
|US20040138517 *||Oct 15, 2003||Jul 15, 2004||Medtronic, Inc.||Multi-modal operation of a medical device system|
|US20040138518 *||Oct 15, 2003||Jul 15, 2004||Medtronic, Inc.||Medical device system with relaying module for treatment of nervous system disorders|
|US20040138536 *||Oct 15, 2003||Jul 15, 2004||Medtronic, Inc.||Clustering of recorded patient neurological activity to determine length of a neurological event|
|US20040138580 *||Oct 15, 2003||Jul 15, 2004||Medtronic, Inc.||Signal quality monitoring and control for a medical device system|
|US20040138647 *||Oct 15, 2003||Jul 15, 2004||Medtronic, Inc.||Cycle mode providing redundant back-up to ensure termination of treatment therapy in a medical device system|
|US20040152958 *||Oct 15, 2003||Aug 5, 2004||Medtronic, Inc.||Timed delay for redelivery of treatment therapy for a medical device system|
|US20040153129 *||Jul 22, 2003||Aug 5, 2004||Neuropace, Inc.||System and method for controlling neurological disorders with spatially separated detection and therapy locations|
|US20040153436 *||Oct 15, 2003||Aug 5, 2004||Pope Cameron A.||Automated information management system and methods|
|US20040158119 *||Oct 15, 2003||Aug 12, 2004||Medtronic, Inc.||Screening techniques for management of a nervous system disorder|
|US20040236387 *||Jun 14, 2004||Nov 25, 2004||Neurocontrol Corporation||Treatment of shoulder dysfunction using a percutaneous intramuscular stimulation system|
|US20040249422 *||Feb 19, 2004||Dec 9, 2004||Gliner Bradford Evan||Systems and methods for enhancing or optimizing neural stimulation therapy for treating symptoms of movement disorders and/or other neurologic dysfunction|
|US20050049650 *||Jul 9, 2004||Mar 3, 2005||Medtronic, Inc.||Method for treating obsessive-compulsive disorder with electrical stimulation of the brain internal capsule|
|US20050113744 *||Nov 21, 2003||May 26, 2005||Cyberkinetics, Inc.||Agent delivery systems and related methods under control of biological electrical signals|
|US20050113886 *||Nov 23, 2004||May 26, 2005||Fischell David R.||Implantable medical system with long range telemetry|
|US20050197590 *||Aug 1, 2002||Sep 8, 2005||Ivan Osorio||System for the prediction, rapid detection, warning, prevention, or control of changes in activity states in the brain of a subject|
|US20050203366 *||Mar 12, 2004||Sep 15, 2005||Donoghue John P.||Neurological event monitoring and therapy systems and related methods|
|US20050209652 *||Apr 22, 2005||Sep 22, 2005||Whitehurst Todd K||Methods and systems for electrical and/or drug stimulation as a therapy for erectile dysfunction|
|US20050267597 *||Nov 19, 2004||Dec 1, 2005||Flaherty J Christopher||Neural interface system with embedded id|
|US20050273890 *||Aug 2, 2005||Dec 8, 2005||Flaherty J C||Neural interface system and method for neural control of multiple devices|
|US20130090706 *||Apr 11, 2013||Randolph J. Nudo||Methods and associated neural prosthetic devices for bridging brain areas to improve function|
|EP0911061A2||Oct 26, 1998||Apr 28, 1999||Neuropace, Inc.||System for the treatment of neurological disorders|
|EP1554011A2 *||Oct 15, 2003||Jul 20, 2005||Northstar Neuroscience, Inc.||Neural stimulation system and method responsive to collateral neural activity|
|WO1985001213A1 *||Sep 11, 1984||Mar 28, 1985||Jacob Zabara||Neurocybernetic prosthesis|
|WO1985001214A1 *||Sep 14, 1984||Mar 28, 1985||Wilton W Webster Jr||Electrophysiological switching unit|
|WO1986002567A1 *||Oct 18, 1985||May 9, 1986||Zion Foundation||Method and apparatus for delivering a prescriptive electrical signal|
|WO1995015117A1 *||Jun 22, 1994||Jun 8, 1995||Univ Washington||Method and apparatus for detecting epileptic seizures|
|WO2002038031A2 *||Oct 30, 2000||May 16, 2002||Neuropace Inc||System and method for determining stimulation parameters for the treatment of epileptic seizures|
|WO2004023983A2 *||Sep 12, 2003||Mar 25, 2004||Univ Michigan||Noninvasive nonlinear systems and methods for predicting seizure|
|WO2004043536A1||Nov 12, 2002||May 27, 2004||Neuropace Inc||System for adaptive brain stimulation|
|WO2006044793A2 *||Oct 17, 2005||Apr 27, 2006||Univ Louisiana Tech Foundation||Medical devices for the detection, prevention and/or treatment of neurological disorders, and methods related thereto|
|U.S. Classification||600/544, 607/45, 607/68, 607/63|