|Publication number||US3855638 A|
|Publication date||Dec 24, 1974|
|Filing date||May 16, 1973|
|Priority date||Jun 4, 1970|
|Also published as||CA962806A1, DE2127843A1|
|Publication number||US 3855638 A, US 3855638A, US-A-3855638, US3855638 A, US3855638A|
|Original Assignee||Ontario Research Foundation|
|Export Citation||BiBTeX, EndNote, RefMan|
|Patent Citations (3), Non-Patent Citations (1), Referenced by (464), Classifications (37) |
|External Links: USPTO, USPTO Assignment, Espacenet|
Surgical prosthetic device with porous metal coating
US 3855638 A
A novel surgical prosthetic device having many useful surgical applications comprises a composite structure. The composite consists of a solid metallic material substrate and a porous coating adhered to and extending at least partially over the surface of the substrate. The porous coating has certain critical characteristics, and the individual values depend on the end use to which the device is put. There are described a number of surgical and dental applications.
United States Patent 11 1 [111 3,855,638 Pilliar 1 Dec. 24, 1974  SURGICAL PROSTHETIC DEVICE WITH 3,314,420 4/1967 Smith et a1 128/92 C OU METAL COATING 3,605,123 9/1971 Hahn 3/1 Inventor: Robert M. Pilliar, Toronto, Ontario,
Canada Assignee: Ontario Research Foundation,
Sheridan Park, Ontario, Canada Filed: May 16, 1973 Appl. No; 360,954
Related US. Application Data Continuationin-part of Ser. No. 148,316, June 1, 1971, abandoned.
Foreign Application Priority Data June 4, 1970 Great Britain 27110/70 Feb. 4, 1971 Great Britain 3964/71 US. Cl. 3/1, 128/92 C, 128/334 R,
128/92 D, 32/10 A Int. Cl. A6lf 1/24 Field of Search. 3/1; 128/92 C, 92 BC, 92 CA,
128/334 R, 92 R, 92 D; 32/10 A; 117/71 M' References Cited UNITED STATES PATENTS Haboush 128/92 CA OTHER PUBLICATIONS Sintered Fiber Metal Composites as a Basis for Attachment of Implants to Bone by V. Galante et al., The Journal of Bone & Joint Surgery, Vol. 53-A, No. 1, January 1971, pages 1011l4.
Primary Examiner-Ronald L. Frinks Attorney, Agent, or Firm-Sim & McBurney  ABSTRACT A novel surgical prosthetic device having many useful surgical applications comprises a composite structure. The composite consists of a solid metallic material substrate and a porous coating adhered to and extending at least partially over the surface of the substrate. The porous coating has certain critical characteristics, and the individual values depend on the end use to which the device is put. There are described a number of surgical and dental applications.
10 Claims, 1 Drawing Figure SURGICAL PROSTHETIC DEVICE WITH POROUS METAL COATING REFERENCE TO RELATED APPLICATION This application is a continuation-in-part of application Ser. No. 148,316 filed June 1, 1971, now abandoned.
FIELD OF INVENTION This invention relates to surgical prosthetic devices.
BACKGROUND TO THE INVENTION The use of surgical prosthetic devices, otherwise known as implants, is well known in various surgical applications, such as reconstructive surgery, for example, in the replacement of hip joints or the like. These applications generally involve the use of an implant constructed of metal or alloy which substantially is not corroded or otherwise degraded by body fluids. These prior art implants, however, suffer from a number of defects.
Typically, in the setting of broken bones metal plates have been used which are secured to either side of the bone fracture. The plates are commonly secured to the bone by screws. While the plate in time becomes encapsulated in bone and body tissue, no bond is formed between the implant and the tissue. If one of the screws comes loose, the patient may have to undergo additional corrective surgery.
Suggestions have been made in the prior art to provide surgical prosthetic devices which are capable of permanent incorporation into the body, usually the bone with bonding between the implant and the tissues.
In one prior art suggestion, there is described a prosthetic device consisting of a metal substrate or base having a thin porous coating of metal overlying and bonded to the surface. The presence of the pores allows the soft or hard tissue to grow into the porous coating of the device and hence achieve incorporation into the body.
The only method of forming the coating which is described in this prior art suggestion is the technique of plasma or flame spraying onto the metal substrate. The result of this process is a densely adherent layer of the sprayed metal on the substrate metal with no porosity or practically no porosity at the interface between the coating and the substrate and with gradually increasing porosity, including increasing pore size and decreasing density, from the interface to the surface of the coating.
While this technique may be effective in providing a porous coating on a metal substrate, nevertheless the technique results in a very serious defect in the finished prosthetic device. In tests designed to show the ingrowth of tissue into the coated surface of the device a pin, having the coating thereon, after embedding in a bone for a period of time was subjected to a pull-out test. This pull-out test resulted in shearing at the interface between the coating and the base metal. This result indicates that the overall strength of the device is less than the bone. Quite clearly, the provision of a device weaker than the bone to which it is attached could result in failure of the device due to shearing at the interface with harmful and painful consequences for a patient who is treated using such a device.
This defect of this device is a direct result of its method of manufacture. Plasma spraying is a well known technique and generally is employed where it is desired to achieve a low porosity coating, often entirely pore free. Very thin plasma coatings therefore tend to be very dense and a progressive increase in pore size and decrease in density is a commonly-known result. If plasma spraying is continued eventually a uniform pore size of the coating is achieved, but the thickness of the coating required is at least ten thousands of an inch.
Another result of plasma or flame spraying is that a very hot molten mass impinges onto a relatively cold substrate surface causing the setting up of considerable interfacial thermal stresses which result in an inherent weakness which manifests itself in the interfacial shearing action observed in tests.
Another prior art suggestion involves the provision of a prosthetic device constructed of porous ceramic material. This material is structurally weak and attempts to overcome this defect involve filling the bulk of the device with resin material, leaving a porous surface area. Although the presence of the resin may increase the strength of the central portion of the device, the surface region remains weak. Further, the presence of resin material degradable by body fluids would lead to unsatisfactory use in the human body. In addition, the maximum pore size for the ceramic is indicated to be 50 microns, and much smaller sizes are preferredv If the .pore size were greater than 50 microns, then the structure would become too weak for effective use. A consequence of this pore size limitation will become apparent hereinafter in the discussion of the present invention SUMMARY OF INVENTION The surgical prosthetic device of the present invention has a unique construction which overcomes the weakness problems associated with the prior art devices, as disscused above. The surgical prosthetic device of the invention comprises a composite structure consisting of a solid metallic material substrate and a porous coating adhered to and extending at least partially over the surface of the substrate. The porous coating on the surface of the substrate has several parameters, described in detail below, which are essential to the provision of a satisfactory device free from the defects of the prior art devices.
The porous coating consists of a plurality of small discrete particles of metallic material bonded together at their points of contact with each other to define a plurality of connected interstitial pores in the coating. The particles are of the same metallic material as the metallic material from which the substrate is formed. It is essential that this be the case otherwise corrosion at the substrate-coating interface may occur due to a cell action with body fluids.
The metallic material from which the substrate and coating are formed is one which is not corroded or otherwise degraded by the body fluids of the patient. Examples of suitable materials include austenitic stainless steel, titanium, titanium alloys and cobalt alloys. The cobalt alloy VITALLIUM (Trademark) has been found to be especially useful.
BRIEF DESCRIPTION OF DRAWING The accompanying drawing is a photomicrograph of the surface structure of an implantin accordance with one embodiment of the invention after four months implantation in a dog femur.
DETAILED DESCRIPTION OF INVENTION In the surgical prosthetic device of the invention, the metal particles are bonded to one another and to the substrate in such a manner that particle-to-particle separation and particle-to-substrate separation would require a shear stress greater than the transverse shear stress required for bone fracture. Thus, in the present invention, the composite structure is stronger than bone and hence is free from the interfacial shearing encountered by the prior art and discussed in detail above and also is free from intracoating failure.
In the present invention, therefore, when tissue ingrowth and tissue ossification is complete, break away of the coated part of the prosthetic device will occur by a bone fracture rather than a fracture within the coating itself or at the coating-substrate interface.
Another essential parameter of the coating which assists in the provision of a superior product is the pore and pore size distribution through the depth of the coating. In the present invention. both the pore and pore size distribution are substantially uniform from the coating-substrate interface to the surface of the coating. This uniformity of pore and pore size distribu' tion through the coating results in a substantial uniformity of strength through the thickness of the coating and ensures ingrowth of tissue and its calcification through the entire thickness of the layer to the interface with the substrate.
These latter conditions are in contrast to the structure of the prior art where there is a progressive increase in pore size and porosity from the coatingsubstrate interface to the surface. The prior art therefore lacks uniformity of strength throughout the thickness of the layer and further does not allow the ingrowth of tissue through the whole depth of the layer, resulting in a less-satisfactory incorporation into the body.
It also is essential to control the interstitial pore size and the coating porosity within critical limits, although variations between the limits may be made depending on the individual requirements. The critical limits depend on the application to which the implant is to be put.
In order for the porous adherent coating to be able to sustain bone, or other hard tissue growth, it is essential that theinterstitial pore size exceed about 50 microns. Generally, the interstitial pore size is between about 50 and lOO microns, although larger pore sizes up to about 200 microns may be employed. Since the particles in the powder from which the coating is formed are not usually of uniform size, the pore sizes vary somewhat throughout the coating, although their distribution is substantially uniform.
Where the ingrowth of soft tissue only is to be sustained, the interstitial pore size may be less than 50 microns, down to about microns.
This finding of essential pore sizes for ingrowth of tissue contrasts markedly with one of the prior art suggestions mentioned above wherein the maximum pore size indicated is 50 microns, with the preferred range being considerably less. This prior art device therefore is capable only of sustaining ingrowth of soft tissue and in its preferred aspects is incapable of sustaining even soft tissue ingrowth. 7
Further, it is essential that the porosity of the surface coating not exceed about 40 percent and be at least about 10 percent. It is only be controlling the porosity within this range at the pore sizes recited above that it is possible to provide a surgical prosthetic device that has an overall strength greater than the shear strength of bone and at the same allow for ingrowth of tissue. At porosities below about 10 percent, there are insufficient pores in the surface to provide sufficient ingrowth whereby upon later calcification a strong mechanical fixation is achieved. At porosities above about 40 percent the overall mechanical strength falls below the required level. The pore size and porosity values are achieved by controlling the manner of formation of the coating and the particle size of the material used in the coating formation.
The depth of the porous coating on the surface of the substrate and the ratio of depth of coating to depth of substrate may vary over a wide range between essential limits. The lower limit of thickness is about I00 microns, which is the thickness of surface coating required to sustain bone tissue ingrowth with good mechanical interlocking in the pores, generally equivalent to about 2 to 3 monolayers of particles, while the upper limit of thickness is about 1,000 microns which is dictated by the strength considerations discussed above. Typically, a depth of about 500 microns is used on about a A1 inch round substrate, using from +325 to -1OO mesh particle coatings.
Referring now to the accompanying photomicrograph there is shown a 250 times magnification of an elongated substrate 10 of circular cross-section and a porous adherent coating 12. The substrate 10 and the coating 12 each are formed of VITALLIUM. The coating 12 is formed of from +325 to l0() mesh powder and a plurality of interconnected interstitial pores filled with bone tissue is provided. The pores and pore size distribution are substantially uniform through the depth of the coating 12.
A dogs femur 14 is situation adjacent the coating 12 and the ingrowth of bone tissue 16 can be seen. The growth of bone tissue is throughout the depth of the coating to the substrate surface. The ingrowth of the bone tissue was woven and lamullar together and had the architectural configuration of adult compact bone with osteone formation. Since the appearance of tissue elements may be deceptive by reflection under the optical microscope, further testing by way of electron microprobe scan analyses of the porous coating 12 was carried out. Probing from the bone 14 across the coating 12 to the substrate 10 showed the calcium and phosphorus contents of the tissue ingrowth 16 to be the same as that of the femur 14. These observations confirm that the coating 12 was not only penetrated by living tissue but it was sufficiently porous to allow the infiltration of bone growth.
The micrograph shows no untoward reaction of the bone tissue 16 to the metal of the coating 12. This observation is significant in view of the large surface area of metal exposed to possible reaction in an open pored structure.
The surgical prosthetic device of the invention has a number of uses. For example, the implant may be used to bridge the gap between bone ends caused by removal of a portion of the bone. The removal of the portion may be due to irreparable shattering, a cancerous growth or the like.
The implant, generally in the form of a cylindrical rod, is positioned within the bone ends. At least those areas of the implant in contact with and adjacent the bone ends are provided with the porous adherent coating. The presence of the porous adherent coating allows bone or hard tissue to grow into the surface of the implant, so that the implant is incorporated'into the bone and the implant thereby is secured to the bone ends.
The implant of the invention by the presence of the porous adherent coating allows bone or hard tissue to grow into the surface of the implant, so that the implant is incorporated into the bone and a much stronger joint is provided.
When the implant is used in this bridging role, in those areas between the bone ends, a porous adherent coating also may be provided on the surface of the implant, so that body (or soft) tissue may grow into the surface. Therefore, the implant is not only encapsulated in the body, but is incorporated into the bone and soft tissue of the patient. In this way, a very rigid structure is obtained.
The process of growth of bone tissue into the porous adherent coating takes some time and it is necessary to provide an initial affixing ofthe bone ends and the plate to position the implant for ingrowth of the bone tissue. In the case of bone setting, the implant, in the form of a plate, may be secured by screws, either side of the break. In the case where the implant is used as a bridge between bone ends, the implant, in the form of an elongated cylindrical rod, may be secured within the bone ends.
A further use of the surgical prosthetic device of the invention lies in artifical joints, for example, a hip prosthesis. When artifical joints are included in the body, it is necessary that they be affixed in the joint socket and this has been achieved using cements. In some joints, such as the hip joint, the stresses at certain positions are greater than at others and it may be desired to utilize adhesion achieved other than by the use of cements.
The artifical joints may be constructed in accordance with the present invention. The coating may be provided on the substrates, if desired, only at those positions where the joint will be subjected to high stress. As in the case of the bridging of bone, the bone tissue of the socket grows into the surface coating and thereby more tightly binds the prosthesis. Cement is used to position the prosthesis in the socket and cement may be employed additionally at the areas of the porous coating. The entire prosthesis may be formed as a composite and it has been found that the use of a cement, such as methyl methacrylate, together with the porous surface gives rise to a much enhanced adhesion of the prosthesis to the socket as compared to use ofa cement in the absence of a porous surface.
In this case, the increased surface area and morphology of the implant occasioned by the presence of the porous coating provides the enhanced adhesion. A further application of the implant of the invention is in a McIntosh arthroplasty of the knee.
An additional use of the implant of the invention is in the affixing of artificial limbs, etc. to amputees. In this embodiment, the implant, usually as an elongated rod, is secured in the bone of the stump. In the area of the implant adjacent the bone, an adherent porous coating is provided in accordance with this invention. The presence of the coating allows bone tissue to grow into the surface of the implant and rigidly secure the implant therein. The rod projects from the stump and after the implant is securely affixed to the bone, the artificial limb then may be secured to the projecting portion.
At least at the portion of the rod adjacent the body surface, the implant is provided with a porous surface. The soft body tissue at the surface of the stump, therefore, may grow into the surface of the implant at the point where it projects from the stump and thereby the surface of the skin is sealed to the implant. In the absence of the porous coating of the invention, such a seal does not form and infection of the stump may occur.
In common with the embodiments discussed above, certain parameters are necessary for the coating in the area of the fixture to the bone in order to sustain bone tissue growth into the coating and the discussion above with reference to the implant used in the setting of bone applies equally here. In particular, the pore size of the porous coating in at least the area of the implant adjacent the bone stump should exceed 50 microns.
The implant of the invention may be used in brain surgery, to replace bone removed from the cranium during a brain operation. The surgical prosthetic device of the invention in this embodiment assumes the form of a circular disc, or other shape, conforming in size to the hole formed in the skull, with a porous adherent coating formed around the peripheral areas where the device engages the skull bone. Bone tissue grows from the skull into the porous surface, and the disc thereby is incorporated into the skull.
The implant of the invention in the form of a staple may be used in the rejoining of tendon, muscle or other soft tissue to bone, for example, in a shoulder. The staple consists of a substrate and a coating, the coating being formed to sustain the growth of bone and soft tissue therein. The implant may be formed with different forms of coating, one area sustaining bone tissue growth and the other soft tissue growth. It is possible to employ a smaller interstitial pore size for soft tissue growth, as discussed above, down to about 20 microns, as compared to the pore size for bone tissue growth where an interstitial pore size exceeding about 50 microns is required.
Another area of use of the present invention is in dentistry. The implant may be anchored to the mandible and at the point of projection of the implant through the gingival, a porous coating is provided. Gum tissue grows into the coating and thereby seals the gum surface. In this way, the collection of foreign substances, causing infection, at the implant-gingival interface is prevented.
The area of the implant adjacent the mandible may be provided with a coating, in accordance with the present invention, in order to more securely anchor the implant to the jaw bone by bone tissue ingrowth.
The implant of the present invention also may be employed to provide a quick-release valve secured to the body surface of a patient for connecting internal parts of the body to external treatment devices. The implant generally consists of a ring of metal having a peripheral porous coating adjacent the areas of attachment to the patients body surface. Since the growth of body tissue into the surface takes time, temporary securement of the implant may be achieved in any desired manner, such as by the use of sutures.
' The ring is formed so that efficient connection between internal parts of the body and devices external of the body may be provided, the particular form depending on the end use.
It will be seen that a novel surgical prosthetic device is provided which has many useful surgical applications and which has many advantages over prior art methods. The enhanced strength of implant to bone or soft tissue provided by the porous adherent surface represents a significant advance in surgery.
The surgical prosthetic device of the invention may be formed in any convenient manner. For example, the porous coating may be formed by diffusion bonding of the particles and the surface. Typically, it is possible to provide a porous adherent coating having the desired characteristics by using metallic particles, such as VI- TALLlUM, having particle sizes from +325 to 100 mesh in this technique. It is not possible to use 325 mesh powder when bone tissue ingrowth and calcification is to be sustained since the interstitial pore sizes of coatings formed from such powder drop below 50 microns. implants including coatings formed from such 325 mesh powder are useful, however, where soft tissue ingrowth is to be sustained, provided that the interstitial pore size does not fall below microns.
One convenient powder metallurgy technique for forming the coating in the device of the present invention utilizes a slurry of metallic powder suspended in aqueous solution with organic binders. The slurry may be held in a mold around the area of the substrate to which it is desired to impart the porous coating. Alternatively, the slurry may be of a consistency to be selfsupporting on the surface.
The slurry is heated to remove the water and finally sintered in an inert or reducing atmosphere, such as hydrogen, to burn off the organic binder and fuse the particles together and to the substrate.
The particle size of the metallic powder and the conditions of formation of the porous coating are controlled to provide the desired interstitial pore size, porosity, strength and depth of coating. For a typical implant of the invention, employing a VlTALLlUM substrate, VlTALLlUM powder of from +325 to lOO mesh particle size requires to be heated at about 2,200F for at least 2 hours in a dry hydrogen atmosphere to provide a satisfactory product. Longer sintering times produces a stronger product.
A study of the effect of firing time on the properties of VITALLIUM powder coating (+325 mesh) at a firing temperature of about 2,200F has indicated a relationship between the density of the coating and the sintering time. The density is related to the porosity and the shear strength of the final coating, and the shear strength therefore varies with sintering time. The results are indicated in the following Table I:
(Average values for samples formed by coating and slurry methods.)
Under certain circumstances, it may be desired to machine the coating to a particular shape and this may be achieved by firing the coating to a strength at which the coating is machinable, machining the coating to the desired shape and then firing the machined coating to the final forms.
The coating may be formed in any other desired manner, for example, from the metallic powder. A depression may be formed in the surface of the substrate, free flowing metallic powder, in the absence of organic binder, may be poured into the depression and the powder tired to produce the coating.
In a typical two-stage operation, a VlTALLiUM coating may be fired at 2,l00 to 2, l 50F for about one hour to give the strength. The coating then is machined and fired again at about 2,200F for at least 2 hours, sometimes for as long as 8 hours, depending on the strength requirements of the final coating.
Where a slurry is used, the mold may be subjected to pressure during whole or part of the firing operation.
It is possible to provide the same pore size at two different positions of tissue ingrowth but in certain circumstances it may be desirable to provide two different types of coating on the same implant.
After formation of the composite structure, if desired, the porous surface may be treated with a variety of materials prior to implant in the body. These materials may include materials to promote the growth of hard or soft tissues or with antibiotics.
In the present invention, both the substrate and the powder are sintered to achieve diffusion bonding between the metal particles and between the metal particles and the substrate, and hence the thermal stresses encountered by the prior art by the use of flame spraying are avoided.
The product of the invention is superior to the prior art in terms of overall strength and ability to sustain satisfactory interlocking ingrowth of both bone and soft tissues.
EXAMPLES The invention is illustrated by the following Examples:
EXAMPLE 1 This example illustrates the formation of a surgical prosthetic device of the invention.
A VlTALLIUM rod of A inch diameter was degreased and cleaned. An aqueous VITALLIUM powder slurry consisting of 74 parts by weight of +325 mesh atomized VITALLlUM powder, 25 parts by weight of an aqueous solution of 1 percent methylcellulose, 1 part by weight of a 2 /2 percent aqueous solution of dioctyl sodium sulfosuccinate and 0.25 parts by weight of ammonium hydroxide was made up. This slurry was applied to the degreased and cleaned Vl- TALLIUM rod to a depth of 1/32 inch.
After drying, the coated rod was sintered at 2,200F in a dry hydrogen atmosphere of 99.99 percent purity for approximately two hours. The product was cooled in the hydrogen atmosphere. Examination of the product indicated that the spherical powder particles had fused at each contact point between themselves and the rod and an interior communicating substantially uniform pore structure with pore sizes ranging from 50 to micron was evident.
9 EXAMPLE n Cylindrical rods cut from the product of Example 1 were implanted into the tibia of adult mongrel dogs. Drill holes were made at right angles to the longitudinal inferior pole of the rods and the samples were mounted in the lnstron machine of Example H for compression testing. The flat undersurface of the acrylic provided an ideal base for conducting the push-out test, care having axes of the tibial shafts and the implants were intro- 5 been taken in embedding the metal 0 ensure that the duced so as to penetrate only the medial cortex, the Compressive forces would be pp directly along the inner portion of the implant being free in the medullary long axis of the cavity The effective area of Contact between the VI The results are reproduced in the following TALLlUM coating and the bone was relatively small, being equal to the cortical surface exposed by the drill- BLE 11] hole.
A push-out test designed to measure h f r VITALLIUM coating Bufied VITALLIUM Stainless SlcCl quired to dislodge the implant from the cortical bone +325 mesh P P P was carried out in the following way. An lnstron tester 1740 530 580 with a compression cell and specially designed adaptor 15 2180 5 15 595 was used to apply compressive loading directly to the 5138 2 :8 implant. The specimen of bone was held rigidly in a 00 610 vice with care being taken to ensure that the line of acof the loading force was directly Perpendicular to It will be seen from these results that the implants that of the imPlamed rods- In h Case, a compression formed in accordance with prior art methods may be load was apphed at a rate of Inches per mmute and dislodged from the acrylic with a force of 500'to 600 the force recorded graphically. The force required to psi. In contrast, with the implant of the present invendlslodge the Implant was taken as that requlred to P tion, the implant could not be dislodged at all; instead duce the first movement of the The force P the acrylic cement shattered, breaking through the line area in P- was Calculated, affording an P of the implant without movement of the metal rod. lt sion of the shear strength of the interface between the is apparent, therefore, that the porous Surface provides bone and the implant materiah a greatly increased surface area for fixation and me- The P force was tested on Various samples chanical interlocking, with consequentially increased after first inserting into the bone and then after four adhesive power. The Cement ddheres much more months implantation. Parallel studies were carried out Strongly to the porous surface and this f t has i using the rods having Poreus Coatings formed from erable practical application in providing greater stabilmesh VITALUUM P By Way of Compari ity for the components of a total hip prosthesis or Mcson, test results on smooth VITALLIUM rods also were lmosh arthroplasty f the knee obtained. The results are reproduced in the following M difi i are possible within the Scope f the Table vention.
TABLE II +325 mesh VlTALLlUM 325 mesh VITALLIUM No coating psi psi VITALLIUM rod psi 0 time 4 months 0 time 4 months 0 time 4 months 148 l520 49 850 2l0 220 164 1670 66 930 240 220 180 l69O 74 1060 270 300 230 1740 90 1060 300 330 278 1780 98 1140 315 340 It will be seen from the results of this Table ll that im- What I claim is: plants of the +325 mesh VITALLIUM coated specimens showed a markedly enhanced bonding character- A Surgical Prosthetic device Comprising p i i i h h force i d to di l d those b i i ite structure consisting of a solid metallic material subh range f 1 500 to 1,800 pounds per square i h strate and a porous coating of said metallic material ad- Th -325 h VITALUUM coated specimens l hered to and extending at least partially over the surb d d b h degree ofenhancement ffi ti face of said substrate to a thickness of about 100 mi- 350 to 1 i i d was l I complete crons to about l,O00 microns, said metallic material trast to these results obtained with products of the in being Substantially non-corrodable n ngr a le vention, the implants formed only of VITALLIUM rod by body fluids, exhibited little or no change in bonding characteristics Said porous coating Consisting of a plurality of small Over a four'month period discrete generally ball-shaped particles of said me- EXAMPLE m tallic material bonded together at their points of contact with each other and said substrate to define Rods of meta] were embedded polymethylmeth' a plurality of connected, interstitial pores uniacrylate cement. The metals involved were VlTAL- f l distributed throughout said Coating LIUM having a coating of +325 mesh VlTALLlUM 65 powder, formed as outlined in Example 1, buffed Vl- TALLIUM and stainless steel.
After 24 hours immersion, the specimens were trimmed so that there was no cement adherent to the said particles being of a size and being spaced from each other to establish an average interstitial pore size of from about 20 microns to about 200 microns substantially uniformly distributed throughout said coating and a coating porosity of between about and about 40 percent.
2. The device of claim 1 wherein said average interstitial pore size is from about 50 to about 200 microns.
3. The device of claim 1 wherein said average interstitial pore size is from about 50 to about 100 microns.
7. The device of claim 6 wherein said particle sizes are from +325 mesh to lOO mesh.
8. The device of claim 2 wherein said coating is impregnated with bone-binding cement.
9. The device of claim 7 wherein said coating is provided to a depth of about 500 microns.
10. The device of claim 1 wherein said solid substrate has two of said porous coatings of said metallic material adhered to and each extending partially over the surface of said substrate to said thickness, one of said porous coatings having an average interstitial pore size below about 50 microns for the ingrowth of soft tissue and the other of said porous coatings having an average interstitial pore size above about 50 microns for the in growth of hard tissue.
|Cited Patent||Filing date||Publication date||Applicant||Title|
|US2668531 *||Feb 15, 1952||Feb 9, 1954||Haboush Edward J||Prosthesis for hip joint|
|US3314420 *||Oct 23, 1961||Apr 18, 1967||Haeger Potteries Inc||Prosthetic parts and methods of making the same|
|US3605123 *||Apr 29, 1969||Sep 20, 1971||Melpar Inc||Bone implant|
|1|| *||Sintered Fiber Metal Composites as a Basis for Attachment of Implants to Bone by V. Galante et al., The Journal of Bone & Joint Surgery, Vol. 53 A, No. 1, January 1971, pages 101 114.|
|Citing Patent||Filing date||Publication date||Applicant||Title|
|US3971134 *||Jan 31, 1975||Jul 27, 1976||General Atomic Company||Carbon dental implant with artificial periodontal ligament|
|US4011602 *||Oct 6, 1975||Mar 15, 1977||Battelle Memorial Institute||Porous expandable device for attachment to bone tissue|
|US4051598 *||Apr 22, 1975||Oct 4, 1977||Meer Sneer||Dental implants|
|US4073999 *||May 9, 1975||Feb 14, 1978||Minnesota Mining And Manufacturing Company||Porous ceramic or metallic coatings and articles|
|US4101984 *||May 5, 1976||Jul 25, 1978||Macgregor David C||Cardiovascular prosthetic devices and implants with porous systems|
|US4156943 *||Aug 24, 1977||Jun 5, 1979||Collier John P||High-strength porous prosthetic device and process for making the same|
|US4186486 *||Nov 4, 1977||Feb 5, 1980||Maurice Gordon||Dental prosthesis|
|US4206516 *||Dec 7, 1977||Jun 10, 1980||Ontario Research Foundation||On coherent solid metal substrate|
|US4252525 *||Dec 17, 1979||Feb 24, 1981||Child Frank W||Dental implant|
|US4255820 *||Jul 24, 1979||Mar 17, 1981||Rothermel Joel E||Artificial ligaments|
|US4272855 *||May 10, 1979||Jun 16, 1981||Sulzer Brothers Limited||Anchoring surface for a bone implant|
|US4278091 *||Feb 1, 1980||Jul 14, 1981||Howmedica, Inc.||Soft tissue retainer for use with bone implants, especially bone staples|
|US4281669 *||Aug 15, 1977||Aug 4, 1981||Macgregor David C||Pacemaker electrode with porous system|
|US4291013 *||Oct 9, 1979||Sep 22, 1981||Merck Patent Gesellschaft Mit Beschrankter Haftung||Medicinally useful, shaped mass of collagen resorbable in the body|
|US4292694 *||Jun 25, 1980||Oct 6, 1981||Lord Corporation||Prosthesis anchoring means|
|US4292695 *||Jun 25, 1980||Oct 6, 1981||Lord Corporation||Prosthesis stem|
|US4309488 *||Jun 21, 1979||Jan 5, 1982||Battelle-Institut E.V.||Implantable bone replacement materials based on calcium phosphate ceramic material in a matrix and process for the production thereof|
|US4322398 *||Feb 21, 1979||Mar 30, 1982||Battelle Institut E.V.||Implantable drug depot and process for the production thereof|
|US4347234 *||Jun 15, 1981||Aug 31, 1982||Merck Patent Gesellschaft Mit Beschrankter Haftung||Medicinally useful, shaped mass of collagen resorbable in the body|
|US4351069 *||Dec 13, 1979||Sep 28, 1982||Union Carbide Corporation||Prosthetic devices having sintered thermoplastic coatings with a porosity gradient|
|US4355426 *||Nov 20, 1979||Oct 26, 1982||Macgregor David C||Porous flexible vascular graft|
|US4355428 *||Nov 5, 1979||Oct 26, 1982||S.A. Benoist Girard & Cie||Surgical prosthesis with grainy surface|
|US4374669 *||Nov 19, 1979||Feb 22, 1983||Mac Gregor David C||Forming porosity coating on metal substrate and heating|
|US4458366 *||Aug 6, 1982||Jul 10, 1984||Macgregor David C||Artificial implantable blood pump|
|US4479271 *||Oct 26, 1981||Oct 30, 1984||Zimmer, Inc.||Tibial component for a knee joint prosthesis|
|US4542539 *||Jan 31, 1984||Sep 24, 1985||Artech Corp.||Surgical implant having a graded porous coating|
|US4549319 *||Aug 3, 1982||Oct 29, 1985||United States Medical Corporation||Artificial joint fixation to bone|
|US4550448 *||Feb 18, 1985||Nov 5, 1985||Pfizer Hospital Products Group, Inc.||Bone prosthesis with porous coating|
|US4608052 *||Apr 25, 1984||Aug 26, 1986||Minnesota Mining And Manufacturing Company||Implant with attachment surface|
|US4612160 *||Apr 2, 1984||Sep 16, 1986||Dynamet, Inc.||Porous metal coating process and mold therefor|
|US4673409 *||Mar 27, 1986||Jun 16, 1987||Minnesota Mining And Manufacturing Company||Implant with attachment surface|
|US4722870 *||Jan 22, 1985||Feb 2, 1988||Interpore International||Metal-ceramic composite material useful for implant devices|
|US4743256 *||Jan 22, 1987||May 10, 1988||Brantigan John W||Surgical prosthetic implant facilitating vertebral interbody fusion and method|
|US4834756 *||Oct 15, 1985||May 30, 1989||Pfizer Hospital Products Group, Inc.||Bone prosthesis with porous coating|
|US4834757 *||Mar 28, 1988||May 30, 1989||Brantigan John W||Prosthetic implant|
|US4851008 *||Feb 1, 1988||Jul 25, 1989||Orthomet, Inc.||Bone implant prosthesis with substantially stress-free outer surface|
|US4865603 *||Feb 4, 1988||Sep 12, 1989||Joint Medical Products Corporation||Metallic prosthetic devices having micro-textured outer surfaces|
|US4878915 *||Jan 4, 1989||Nov 7, 1989||Brantigan John W||Surgical prosthetic implant facilitating vertebral interbody fusion|
|US4880429 *||Jul 20, 1987||Nov 14, 1989||Stone Kevin R||Porous wedge-shaped matrix of collagen fibers interspersed with glycosaminoglycan molecules; for implanting in knees|
|US4904260 *||Jul 25, 1988||Feb 27, 1990||Cedar Surgical, Inc.||Prosthetic disc containing therapeutic material|
|US4904265 *||Sep 9, 1988||Feb 27, 1990||Boehringer Mannheim Corporation||Cementless acetabular implant|
|US4934381 *||Mar 14, 1985||Jun 19, 1990||Macgregor David C||Coating allowing the ingrowth of tissue for stability; anticoagulants|
|US4938769 *||May 31, 1989||Jul 3, 1990||Shaw James A||Modular tibial prosthesis|
|US4997445 *||Dec 8, 1989||Mar 5, 1991||Zimmer, Inc.||Metal-backed prosthetic implant with enhanced bonding of polyethylene portion to metal base|
|US5004476 *||Oct 31, 1989||Apr 2, 1991||Tulane University||Porous coated total hip replacement system|
|US5007931 *||May 4, 1990||Apr 16, 1991||Boehringer Mannheim Corporation||Porous coated prosthesis|
|US5007934 *||Mar 2, 1989||Apr 16, 1991||Regen Corporation||Prosthetic meniscus|
|US5013324 *||Nov 28, 1988||May 7, 1991||Zimmer, Inc.||Prosthetic implant with wrapped porous surface|
|US5018285 *||Jan 16, 1990||May 28, 1991||Zimmer, Inc.||Method of constructing prosthetic implant with wrapped porous surface|
|US5032445 *||Apr 5, 1989||Jul 16, 1991||W. L. Gore & Associates||Methods and articles for treating periodontal disease and bone defects|
|US5035713 *||Feb 12, 1990||Jul 30, 1991||Orthopaedic Research Institute, Inc.||Surgical implants incorporating re-entrant material|
|US5047056 *||Feb 16, 1990||Sep 10, 1991||Pfizer, Inc.||Canine hip prosthesis|
|US5080671 *||Jul 31, 1989||Jan 14, 1992||Uri Oron||Method of treating a metal prosthetic device prior to surgical implantation to enhance bone growth relative thereto following implantation|
|US5080672 *||Oct 27, 1989||Jan 14, 1992||John Bellis||Method of applying a fully alloyed porous metallic coating to a surface of a metallic prosthesis component and product produced thereby|
|US5093179 *||May 7, 1991||Mar 3, 1992||Scantlebury Todd V||Polytetrafluoroethylene|
|US5098434 *||Nov 28, 1990||Mar 24, 1992||Boehringer Mannheim Corporation||Porous coated bone screw|
|US5108432 *||Jun 24, 1990||Apr 28, 1992||Pfizer Hospital Products Group, Inc.||Porous fixation surface|
|US5108435 *||Dec 19, 1990||Apr 28, 1992||Pfizer Hospital Products Group, Inc.||Cast bone ingrowth surface|
|US5108438 *||May 7, 1990||Apr 28, 1992||Regen Corporation||Scaffold for regrowth; dry, porous, volume matrix of biocompatible and bioresorbable fibers|
|US5116374 *||Sep 13, 1990||May 26, 1992||Regen Corporation||Prosthetic meniscus|
|US5158574 *||Nov 7, 1991||Oct 27, 1992||Regen Corporation||Prosthetic meniscus|
|US5192324 *||Jan 2, 1990||Mar 9, 1993||Howmedica Inc.||Bone prosthesis with porous coating|
|US5201766 *||Feb 28, 1991||Apr 13, 1993||Smith & Nephew Richards Inc.||Prosthetic device with porous matrix and method of manufacture|
|US5222983 *||Sep 13, 1991||Jun 29, 1993||Thera Patent Gmbh & Co.||Implantable prosthesis|
|US5258043 *||Dec 26, 1991||Nov 2, 1993||Regen Corporation||Method for making a prosthetic intervertebral disc|
|US5282863 *||Jul 24, 1992||Feb 1, 1994||Charles V. Burton||Flexible stabilization system for a vertebral column|
|US5306311 *||Dec 17, 1991||Apr 26, 1994||Regen Corporation||Prosthetic articular cartilage|
|US5344457 *||Feb 2, 1993||Sep 6, 1994||The University Of Toronto Innovations Foundation||For insertion into bone to connect a prosthesis|
|US5360452 *||Dec 6, 1993||Nov 1, 1994||Depuy Inc.||Enhanced fixation system for a prosthetic implant|
|US5368881 *||Jun 10, 1993||Nov 29, 1994||Depuy, Inc.||Prosthesis with highly convoluted surface|
|US5383931 *||Jan 3, 1992||Jan 24, 1995||Synthes (U.S.A.)||Resorbable implantable device for the reconstruction of the orbit of the human skull|
|US5387243 *||Nov 23, 1992||Feb 7, 1995||Zimmer, Inc.||Method for converting a cementable implant to a press fit implant|
|US5441537 *||Dec 4, 1992||Aug 15, 1995||Howmedica Inc.||Containing bonded spherical particles|
|US5480444 *||Jun 2, 1994||Jan 2, 1996||Incavo; Stephen J.||Hybrid tibial tray knee prosthesis|
|US5489306 *||Jan 3, 1995||Feb 6, 1996||Gorski; Jerrold M.||Graduated porosity implant for fibro-osseous integration|
|US5496372 *||Dec 1, 1993||Mar 5, 1996||Kyocera Corporation||Hard tissue prosthesis including porous thin metal sheets|
|US5522894 *||Mar 29, 1993||Jun 4, 1996||Draenert; Klaus||Bone replacement material made of absorbable beads|
|US5603338 *||May 20, 1996||Feb 18, 1997||Innovative Implants, Inc.||Grit blasting surface of titanium implant to roughen, etching with hydrofluoric acid to remove native oxide, etching with mixture of sulfuric and hydrochloric acids to produce uniformly roughened surface|
|US5607480 *||Nov 10, 1993||Mar 4, 1997||Implant Innovations, Inc.||Surgically implantable prosthetic devices|
|US5624463 *||Apr 25, 1994||Apr 29, 1997||Regen Biologics, Inc.||Prosthetic articular cartilage|
|US5639237 *||Jun 8, 1995||Jun 17, 1997||Fontenot; Mark G||Cylindrical rods; biocompatibility; indentations having concave surfaces coated with hydroxyapatite|
|US5645591 *||May 29, 1990||Jul 8, 1997||Stryker Corporation||Forming bone in shape of inplanted device|
|US5672284 *||Mar 1, 1996||Sep 30, 1997||Zimmer, Inc.||Method of making orthopaedic implant by welding|
|US5681353 *||May 27, 1994||Oct 28, 1997||Regen Biologics, Inc.||Insertion into joints|
|US5683471 *||Sep 12, 1995||Nov 4, 1997||Incavo; Stephen J.||Hybrid tibial tray knee prosthesis|
|US5702483 *||Nov 15, 1995||Dec 30, 1997||Kwong; Louis M.||Debris isolating prosthetic hip joint|
|US5732469 *||May 9, 1995||Mar 31, 1998||Kyocera Corporation||Prosthesis and a method of making the same|
|US5735902 *||Oct 23, 1996||Apr 7, 1998||Regen Biologics, Inc.||Comprising biocompatible resorbable biopolymeric fibers; bone surgery|
|US5735903 *||Jun 1, 1995||Apr 7, 1998||Li; Shu-Tung||Meniscal augmentation device|
|US5741253 *||Oct 29, 1992||Apr 21, 1998||Michelson; Gary Karlin||Method for inserting spinal implants|
|US5769781 *||Nov 13, 1995||Jun 23, 1998||Chappuis; James L.||Protector retractor|
|US5772661 *||Feb 27, 1995||Jun 30, 1998||Michelson; Gary Karlin||Methods and instrumentation for the surgical correction of human thoracic and lumbar spinal disease from the antero-lateral aspect of the spine|
|US5773789 *||May 23, 1996||Jun 30, 1998||Bristol-Myers Squibb Company||Using-laser beam welding|
|US5797909 *||Jun 7, 1995||Aug 25, 1998||Michelson; Gary Karlin||Apparatus for inserting spinal implants|
|US5816811 *||Sep 6, 1996||Oct 6, 1998||Implant Innovations, Inc.||Surgically implantable prosthetic devices|
|US5843172 *||Apr 15, 1997||Dec 1, 1998||Advanced Cardiovascular Systems, Inc.||Porous medicated stent|
|US5863201 *||Jan 3, 1997||Jan 26, 1999||Implant Innovations, Inc.||Infection-blocking dental implant|
|US5876453 *||Feb 27, 1996||Mar 2, 1999||Implant Innovations, Inc.||Implant surface preparation|
|US5876454 *||Jun 28, 1996||Mar 2, 1999||Universite De Montreal||Modified implant with bioactive conjugates on its surface for improved integration|
|US5885299 *||Mar 14, 1996||Mar 23, 1999||Surgical Dynamics, Inc.||Apparatus and method for implant insertion|
|US5961554 *||Dec 31, 1996||Oct 5, 1999||Janson; Frank S||Titanium or alloy|
|US5973222 *||Jan 16, 1998||Oct 26, 1999||Bristol-Myers Squibb Co.||Orthopedic implant having a porous metal pad|
|US5986169 *||Dec 31, 1997||Nov 16, 1999||Biorthex Inc.||Porous nickel-titanium alloy article|
|US5989027 *||Dec 8, 1995||Nov 23, 1999||Sulzer Calcitek Inc.||Dental implant having multiple textured surfaces|
|US6031148 *||Apr 2, 1993||Feb 29, 2000||W. L. Gore & Associates, Inc.||A multilayer medical article for the separation and regeneration of tissue|
|US6042610 *||Feb 24, 1998||Mar 28, 2000||Regen Biologics, Inc.||Meniscal augmentation device|
|US6049054 *||Aug 21, 1997||Apr 11, 2000||Bristol-Myers Squibb Company||Method of making an orthopaedic implant having a porous metal pad|
|US6095817 *||Feb 24, 1999||Aug 1, 2000||Sulzer Calcitek Inc.||Dental implant having multiple textured surfaces|
|US6096038 *||Jun 7, 1995||Aug 1, 2000||Michelson; Gary Karlin||Apparatus for inserting spinal implants|
|US6120502 *||May 27, 1994||Sep 19, 2000||Michelson; Gary Karlin||Apparatus and method for the delivery of electrical current for interbody spinal arthrodesis|
|US6123705 *||Oct 1, 1996||Sep 26, 2000||Sdgi Holdings, Inc.||Interbody spinal fusion implants|
|US6132674 *||Sep 15, 1998||Oct 17, 2000||Bristol-Myers Squibb Company||Porous surface for implants, spraying a water soluble binder solution, contacting porous layer and bonding binder layer on said implant;|
|US6149650 *||May 8, 1998||Nov 21, 2000||Michelson; Gary Karlin||Threaded spinal implant|
|US6193761 *||Sep 30, 1996||Feb 27, 2001||Depuy Orthopaedics, Inc.||Implantable prosthesis with metallic porous bead preforms applied during casting|
|US6209621||Jul 7, 1995||Apr 3, 2001||Depuy Orthopaedics, Inc.||Implantable prostheses with metallic porous bead preforms applied during casting and method of forming the same|
|US6210412||Jun 7, 1995||Apr 3, 2001||Gary Karlin Michelson||Method for inserting frusto-conical interbody spinal fusion implants|
|US6224595||Apr 20, 1998||May 1, 2001||Sofamor Danek Holdings, Inc.||Method for inserting a spinal implant|
|US6240616||Apr 15, 1997||Jun 5, 2001||Advanced Cardiovascular Systems, Inc.||Method of manufacturing a medicated porous metal prosthesis|
|US6261322||May 14, 1998||Jul 17, 2001||Hayes Medical, Inc.||Implant with composite coating|
|US6264656||May 8, 1998||Jul 24, 2001||Gary Karlin Michelson||Threaded spinal implant|
|US6270498||Jun 7, 1995||Aug 7, 2001||Gary Karlin Michelson||Apparatus for inserting spinal implants|
|US6405078||Aug 10, 1999||Jun 11, 2002||Biosense Webster, Inc.||Porous irrigated tip electrode catheter|
|US6419704||Oct 8, 1999||Jul 16, 2002||Bret Ferree||Artificial intervertebral disc replacement methods and apparatus|
|US6454804||Oct 16, 2000||Sep 24, 2002||Bret A. Ferree||Engineered tissue annulus fibrosis augmentation methods and apparatus|
|US6466818||Aug 10, 1999||Oct 15, 2002||Biosense Webster, Inc.||Porous irrigated tip electrode catheter|
|US6468308||Jun 25, 1998||Oct 22, 2002||Stryker Corporation||Synthetic bone matrix|
|US6491723||Mar 1, 1999||Dec 10, 2002||Implant Innovations, Inc.||Removing oxides from titanium implant by etching with hydrogen fluoride|
|US6520996||Jun 5, 2000||Feb 18, 2003||Depuy Acromed, Incorporated||Orthopedic implant|
|US6544472||Jun 14, 2000||Apr 8, 2003||Zimmer, Inc.||Method of making an orthopaedic implant having a porous surface|
|US6572654||Oct 4, 2000||Jun 3, 2003||Albert N. Santilli||Intervertebral spacer|
|US6585647||Jul 21, 1999||Jul 1, 2003||Alan A. Winder||Method and means for synthetic structural imaging and volume estimation of biological tissue organs|
|US6605089||Sep 23, 1999||Aug 12, 2003||Gary Karlin Michelson||Apparatus and method for the delivery of electrical current for interbody spinal arthrodesis|
|US6605117||Jun 15, 2001||Aug 12, 2003||Stryker Corporation||Synthetic bone matrix|
|US6648919||Jun 13, 2002||Nov 18, 2003||Bret A. Ferree||Treating spinal degeneration or herniation; incorporating fibrocytes and/or chondrocytes|
|US6648920||Jun 13, 2002||Nov 18, 2003||Bret A. Ferree||Harvested fibrocytes or annulus fibrosis related cells combined with extracellular matrix; restoring height|
|US6652591||Nov 20, 2001||Nov 25, 2003||Depuy Orthopaedics, Inc.||Prosthesis with feature aligned to trabeculae|
|US6652765||Feb 6, 2001||Nov 25, 2003||Implant Innovations, Inc.||Improving bone bonding; acid etch removal of native oxide layer from titanium device and roughening|
|US6652804||Apr 17, 1998||Nov 25, 2003||Gkn Sinter Metals Gmbh||Method for producing an openly porous sintered metal film|
|US6673075||Dec 3, 2001||Jan 6, 2004||Albert N. Santilli||Porous intervertebral spacer|
|US6702855 *||Jan 27, 2000||Mar 9, 2004||Institut Straumann Ag||Osteophilic implants|
|US6709462||Jan 11, 2002||Mar 23, 2004||Mayo Foundation For Medical Education And Research||Acetabular shell with screw access channels|
|US6723120||Sep 3, 2002||Apr 20, 2004||Advanced Cardiovascular Systems, Inc.||Medicated porous metal prosthesis|
|US6755863||Jun 13, 2002||Jun 29, 2004||Bret A. Ferree||Rotator cuff repair using engineered tissues|
|US6755866||Aug 20, 2002||Jun 29, 2004||Depuy Products, Inc.||Prosthetic stem with bearings|
|US6758849||Aug 18, 2000||Jul 6, 2004||Sdgi Holdings, Inc.||Interbody spinal fusion implants|
|US6770074||Nov 17, 2001||Aug 3, 2004||Gary Karlin Michelson||Apparatus for use in inserting spinal implants|
|US6793677||May 10, 2002||Sep 21, 2004||Bret A. Ferree||Preparation and spinal disc insertion of nucleus pulposus cells or tissue|
|US6797007 *||Mar 25, 1999||Sep 28, 2004||Ceramtec Ag Innovative Ceramic Engineering||Press fit connection between prosthesis components of joint prostheses|
|US6802867||Dec 20, 2002||Oct 12, 2004||Depuy Acromed, Inc.||Orthopedic implant|
|US6805898||Sep 28, 2000||Oct 19, 2004||Advanced Cardiovascular Systems, Inc.||Surface features of an implantable medical device|
|US6875213||Feb 21, 2003||Apr 5, 2005||Sdgi Holdings, Inc.||Method of inserting spinal implants with the use of imaging|
|US6908486||Jan 23, 2003||Jun 21, 2005||Mayo Foundation For Medical Education And Research||Modular acetabular anti-protrusio cage and porous ingrowth cup combination|
|US6923810||Jun 7, 1995||Aug 2, 2005||Gary Karlin Michelson||Frusto-conical interbody spinal fusion implants|
|US6932308||Oct 25, 2001||Aug 23, 2005||Exogen, Inc.||Transducer mounting assembly|
|US6945448 *||Jun 6, 2003||Sep 20, 2005||Zimmer Technology, Inc.||Method for attaching a porous metal layer to a metal substrate|
|US6949124||Sep 24, 2003||Sep 27, 2005||Depuy Products, Inc.||Prosthesis with feature aligned to trabeculae|
|US6969404||Apr 11, 2002||Nov 29, 2005||Ferree Bret A||Annulus fibrosis augmentation methods and apparatus|
|US6969474||Nov 5, 2003||Nov 29, 2005||Implant Innovations, Inc.||removing native titanium oxide layer from titanium bone implant,acid etching the oxide removed surface to form a uniform surface roughness, depositing a layer of hydroxyapatite on acid-etched surface|
|US7060100||Jul 16, 2004||Jun 13, 2006||Ferree Bret A||Artificial disc and joint replacements with modular cushioning components|
|US7074479 *||Mar 14, 2001||Jul 11, 2006||Ceramtec Ag Innovative Ceramic Engineering||Sintered shaped body, whose surface comprises a porous layer and a method for the production thereof|
|US7105030||Jul 9, 2001||Sep 12, 2006||Hayes Medical, Inc.||Implant with composite coating|
|US7108663||Dec 20, 2001||Sep 19, 2006||Exogen, Inc.||Method and apparatus for cartilage growth stimulation|
|US7169185||May 26, 2004||Jan 30, 2007||Impact Science And Technology, Inc.||Canine acetabular cup|
|US7169317||Jul 1, 2005||Jan 30, 2007||Implant Innovations, Inc.||Removing native titanium oxide layer from titanium bone implant, acid etching surface to form a uniform surface roughness, depositing a layer of hydroxyapatite on acid-etched surface; enhanced bonding|
|US7189262||Nov 25, 2003||Mar 13, 2007||Hayes Medical, Inc.||Bimetal tibial component construct for knee joint prosthesis|
|US7201774||Apr 4, 2003||Apr 10, 2007||Ferree Bret A||Artificial intervertebral disc replacements incorporating reinforced wall sections|
|US7201776||Nov 25, 2002||Apr 10, 2007||Ferree Bret A||Artificial intervertebral disc replacements with endplates|
|US7207991||Mar 18, 2002||Apr 24, 2007||Warsaw Orthopedic, Inc.||Method for the endoscopic correction of spinal disease|
|US7208222||Jul 23, 2004||Apr 24, 2007||Viasys Healthcare Inc.||Assembled non-random foams|
|US7211060||May 6, 1999||May 1, 2007||Exogen, Inc.||Ultrasound bandages|
|US7214246||Jun 24, 2005||May 8, 2007||Depuy Orthopaedics, Inc.||Prosthesis with feature aligned to trabeculae|
|US7241313 *||Aug 12, 2002||Jul 10, 2007||Stanmore Implants Worldwide Limited||Surgical implant|
|US7264622||Oct 24, 2003||Sep 4, 2007||Warsaw Orthopedic, Inc.||System for radial bone displacement|
|US7291149||Oct 4, 1999||Nov 6, 2007||Warsaw Orthopedic, Inc.||Method for inserting interbody spinal fusion implants|
|US7309359||Aug 21, 2003||Dec 18, 2007||Warsaw Orthopedic, Inc.||Allogenic/xenogenic implants and methods for augmenting or repairing intervertebral discs|
|US7326214||Aug 9, 2003||Feb 5, 2008||Warsaw Orthopedic, Inc.||Bone cutting device having a cutting edge with a non-extending center|
|US7329284||Sep 27, 2002||Feb 12, 2008||Depuy Products, Inc.||Concave resurfacing prosthesis|
|US7335314||Aug 4, 2004||Feb 26, 2008||Advanced Cardiovascular Systems Inc.||Method of making an implantable medical device|
|US7399303||Aug 20, 2002||Jul 15, 2008||Warsaw Orthopedic, Inc.||Bone cutting device and method for use thereof|
|US7410469||May 18, 2000||Aug 12, 2008||Exogen, Inc.||Apparatus and method for ultrasonically and electromagnetically treating tissue|
|US7429248||Aug 9, 2001||Sep 30, 2008||Exogen, Inc.||Method and apparatus for controlling acoustic modes in tissue healing applications|
|US7429249||Jun 14, 2000||Sep 30, 2008||Exogen, Inc.||Injecting a capsule comprising a piezoelectric sensor and an ultrasound contrast agent that acts as a wound healing agent when ultrasound is applied, impinging ultrasonic waves near the injury; acoustic intracellular microstreaming; bone injuries|
|US7431722||Jun 6, 2000||Oct 7, 2008||Warsaw Orthopedic, Inc.||Apparatus including a guard member having a passage with a non-circular cross section for providing protected access to the spine|
|US7435260||Jun 25, 2004||Oct 14, 2008||Ferree Bret A||Use of morphogenetic proteins to treat human disc disease|
|US7445640||Jan 10, 2006||Nov 4, 2008||Hayes Medical, Inc.||Implant with composite coating|
|US7452359||Jun 7, 1995||Nov 18, 2008||Warsaw Orthopedic, Inc.||Apparatus for inserting spinal implants|
|US7455672||Jul 31, 2003||Nov 25, 2008||Gary Karlin Michelson||Method for the delivery of electrical current to promote bone growth between adjacent bone masses|
|US7491205||Jun 7, 1995||Feb 17, 2009||Warsaw Orthopedic, Inc.||Instrumentation for the surgical correction of human thoracic and lumbar spinal disease from the lateral aspect of the spine|
|US7501073||Feb 2, 2004||Mar 10, 2009||Depuy Products, Inc.||Methods for producing metallic implants having roughened surfaces|
|US7513912||Mar 13, 2007||Apr 7, 2009||Hayes Medical, Inc.||Bimetal tibial component construct for knee joint prosthesis|
|US7527631||Mar 31, 2003||May 5, 2009||Depuy Products, Inc.||Arthroplasty sizing gauge|
|US7534254||Jun 7, 1995||May 19, 2009||Warsaw Orthopedic, Inc.||Threaded frusto-conical interbody spinal fusion implants|
|US7544208||May 2, 2005||Jun 9, 2009||Theken Spine, Llc||Adjustable corpectomy apparatus|
|US7547399||Jan 9, 2007||Jun 16, 2009||Biomet 3I, Llc||Implant surface preparation|
|US7550091||Feb 19, 2008||Jun 23, 2009||Biomet 3I, Llc||Implant surface preparation|
|US7569054||Nov 8, 2005||Aug 4, 2009||Warsaw Orthopedic, Inc.||Tubular member having a passage and opposed bone contacting extensions|
|US7597715||Feb 17, 2006||Oct 6, 2009||Biomet Manufacturing Corp.||Method and apparatus for use of porous implants|
|US7608105||Jul 20, 2005||Oct 27, 2009||Howmedica Osteonics Corp.||Methods of inserting conically-shaped fusion cages|
|US7628764||Aug 13, 2001||Dec 8, 2009||Exogen, Inc.||Ultrasonic treatment for wounds|
|US7635447||Feb 17, 2006||Dec 22, 2009||Biomet Manufacturing Corp.||removing the spacing agent by melting or sublimation a moldings which contains the mixture of metal/alloy powder and a spacing agent ammonium bicarbonate, to form a plurality of pores; promotes soft and hard tissue ingrowth|
|US7655162 *||Mar 2, 2006||Feb 2, 2010||Biomet Manufacturing Corp.||plasma spraying working surface (mandreal) with mixture of Al2o3 and TiO2 and/or Ti, as thickness builds up, the relative amount of aluminum oxide is decreased such that the composition is all Ti and TiO2, after desired thickness, the acetabular shell is extracted from mandreal; hip implant|
|US7686805||Jul 1, 2004||Mar 30, 2010||Warsaw Orthopedic, Inc.||Methods for distraction of a disc space|
|US7691148||Mar 19, 2005||Apr 6, 2010||Warsaw Orthopedic, Inc.||Frusto-conical spinal implant|
|US7699203||Nov 13, 2006||Apr 20, 2010||Warsaw Orthopedic, Inc.||Variable angle surgical staple inserter|
|US7699890||Jan 28, 2004||Apr 20, 2010||Advanced Cardiovascular Systems, Inc.||Medicated porous metal prosthesis and a method of making the same|
|US7713303||Apr 28, 2005||May 11, 2010||Warsaw Orthopedic, Inc.||Collagen-based materials and methods for augmenting intervertebral discs|
|US7713307 *||May 23, 2000||May 11, 2010||Nobel Biocare Ab (Publ.)||Layer arranged on implant for bone or tissue structure|
|US7722619||Apr 25, 2006||May 25, 2010||Warsaw Orthopedic, Inc.||Method of maintaining distraction of a spinal disc space|
|US7722735||Apr 6, 2007||May 25, 2010||C3 Materials Corp.||Microstructure applique and method for making same|
|US7731981||Jan 23, 2007||Jun 8, 2010||Warsaw Orthopedic, Inc.||surgical injection of dehydrated particles or a gel or suspension into the joint; mixtures may also include radiocontrast materials, analgesics, antibiotics, proteoglycans, growth factors, and other cells to promote healing and proper joint function|
|US7744627 *||Jun 17, 2003||Jun 29, 2010||Tyco Healthcare Group Lp||Annular support structures|
|US7744651||Jan 6, 2005||Jun 29, 2010||Warsaw Orthopedic, Inc||Compositions and methods for treating intervertebral discs with collagen-based materials|
|US7789841||Apr 24, 2002||Sep 7, 2010||Exogen, Inc.||Method and apparatus for connective tissue treatment|
|US7796791||Nov 7, 2003||Sep 14, 2010||Conformis, Inc.||Methods for determining meniscal size and shape and for devising treatment|
|US7799085||Apr 2, 2004||Sep 21, 2010||Depuy Products, Inc.||Modular implant system with fully porous coated sleeve|
|US7828800||May 18, 2009||Nov 9, 2010||Warsaw Orthopedic, Inc.||Threaded frusto-conical interbody spinal fusion implants|
|US7850452||Apr 27, 2005||Dec 14, 2010||Biomet 3I, Llc||Pre-stressed implant component and assembly|
|US7850738||Nov 15, 2004||Dec 14, 2010||Hayes Jr Daniel E E||Bimetal acetabular component construct for hip joint prosthesis|
|US7857987||Feb 13, 2008||Dec 28, 2010||Biomet 3I, Llc||Implant surface preparation|
|US7879042||Mar 5, 2004||Feb 1, 2011||Depuy Products, Inc.||Surface replacement extractor device and associated method|
|US7881768||Apr 24, 2007||Feb 1, 2011||The Board Of Trustees Of The Leland Stanford Junior University||Assessing the condition of a joint and devising treatment|
|US7883661||Sep 11, 2009||Feb 8, 2011||Biomet Manufacturing Corp.||removing spacing agent by melting or sublimation of a molding which contains the mixture of metal/alloy powder and a spacing agent ammonium bicarbonate, to form a plurality of pores; promotes soft and hard tissue ingrowth|
|US7887565||Feb 18, 2006||Feb 15, 2011||Warsaw Orthopedic, Inc.||Apparatus and method for sequential distraction|
|US7887593||Sep 18, 2003||Feb 15, 2011||Warsaw Orthopedic, Inc.||Method of implanting natural tissue within the vertebral disc nucleus space using a drawstring|
|US7892287||Sep 27, 2004||Feb 22, 2011||Depuy Products, Inc.||Glenoid augment and associated method|
|US7901462 *||Jun 23, 2005||Mar 8, 2011||Depuy Products, Inc.||Implants with textured surface and methods for producing the same|
|US7914530||Apr 25, 2006||Mar 29, 2011||Warsaw Orthopedic, Inc.||Tissue dilator and method for performing a spinal procedure|
|US7918382 *||Apr 18, 2005||Apr 5, 2011||Zimmer Technology, Inc.||Method for attaching a porous metal layer to a metal substrate|
|US7918876||Mar 24, 2004||Apr 5, 2011||Theken Spine, Llc||Spinal implant adjustment device|
|US7922769||Sep 27, 2004||Apr 12, 2011||Depuy Products, Inc.||Modular glenoid prosthesis and associated method|
|US7923068||Feb 12, 2008||Apr 12, 2011||Lotus Applied Technology, Llc||Fabrication of composite materials using atomic layer deposition|
|US7927335||Sep 27, 2004||Apr 19, 2011||Depuy Products, Inc.||Instrument for preparing an implant support surface and associated method|
|US7935116||Nov 25, 2008||May 3, 2011||Gary Karlin Michelson||Implant for the delivery of electrical current to promote bone growth between adjacent bone masses|
|US7935118||Jun 21, 2002||May 3, 2011||Depuy Products, Inc.||Prosthesis removal cutting guide, cutting tool and method|
|US7942933||Apr 3, 2010||May 17, 2011||Warsaw Orthopedic, Inc.||Frusto-conical spinal implant|
|US7981158||Jun 9, 2008||Jul 19, 2011||Conformis, Inc.||Patient selectable joint arthroplasty devices and surgical tools|
|US7993347||Jul 27, 2000||Aug 9, 2011||Warsaw Orthopedic, Inc.||Guard for use in performing human interbody spinal surgery|
|US7998523||Oct 12, 2006||Aug 16, 2011||Smith And Nephew Orthopaedics Ag||Open-pore biocompatible surface layer for an implant, methods of production and use|
|US8007529||Aug 1, 2008||Aug 30, 2011||Advanced Cardiovascular Systems, Inc.||Medicated porous metal prosthesis|
|US8021432||Oct 11, 2006||Sep 20, 2011||Biomet Manufacturing Corp.||Apparatus for use of porous implants|
|US8036729||Jan 22, 2004||Oct 11, 2011||The Board Of Trustees Of The Leland Stanford Junior University||Assessing the condition of a joint and devising treatment|
|US8052912||Oct 1, 2004||Nov 8, 2011||Advanced Cardiovascular Systems, Inc.||Temperature controlled crimping|
|US8057475||Nov 9, 2010||Nov 15, 2011||Warsaw Orthopedic, Inc.||Threaded interbody spinal fusion implant|
|US8062302||Jun 9, 2008||Nov 22, 2011||Conformis, Inc.||Surgical tools for arthroplasty|
|US8066705||Feb 21, 2003||Nov 29, 2011||Warsaw Orthopedic, Inc.||Instrumentation for the endoscopic correction of spinal disease|
|US8066708||Feb 6, 2007||Nov 29, 2011||Conformis, Inc.||Patient selectable joint arthroplasty devices and surgical tools|
|US8066770 *||Dec 20, 2007||Nov 29, 2011||Depuy Products, Inc.||Sintered coatings for implantable prostheses|
|US8066778||Feb 22, 2007||Nov 29, 2011||Biomet Manufacturing Corp.||Porous metal cup with cobalt bearing surface|
|US8070755||Mar 24, 2009||Dec 6, 2011||Depuy Products, Inc.||Joint arthroplasty kit and method|
|US8077950||Aug 10, 2010||Dec 13, 2011||Conformis, Inc.||Methods for determining meniscal size and shape and for devising treatment|
|US8083745||Mar 14, 2008||Dec 27, 2011||Conformis, Inc.||Surgical tools for arthroplasty|
|US8105327||Mar 5, 2004||Jan 31, 2012||Depuy Products, Inc.||Punch, implant and associated method|
|US8105330||Jun 9, 2008||Jan 31, 2012||Conformis, Inc.||Patient selectable joint arthroplasty devices and surgical tools|
|US8112142||Jun 27, 2007||Feb 7, 2012||The Board Of Trustees Of The Leland Stanford Junior University||Assessing the condition of a joint and devising treatment|
|US8114156 *||Mar 12, 2009||Feb 14, 2012||Edwin Burton Hatch||Flexibly compliant ceramic prosthetic meniscus for the replacement of damaged cartilage in orthopedic surgical repair or reconstruction of hip, knee, ankle, shoulder, elbow, wrist and other anatomical joints|
|US8118779||Jun 30, 2006||Feb 21, 2012||Warsaw Orthopedic, Inc.||Collagen delivery device|
|US8122582||Jan 28, 2009||Feb 28, 2012||Conformis, Inc.||Surgical tools facilitating increased accuracy, speed and simplicity in performing joint arthroplasty|
|US8123707||Jun 18, 2010||Feb 28, 2012||Exogen, Inc.||Method and apparatus for connective tissue treatment|
|US8123814||Jun 26, 2007||Feb 28, 2012||Biomet Manufacturing Corp.||Method and appartus for acetabular reconstruction|
|US8128703||Nov 17, 2009||Mar 6, 2012||Depuy Products, Inc.||Fixed-bearing knee prosthesis having interchangeable components|
|US8142510||Mar 17, 2008||Mar 27, 2012||Depuy Products, Inc.||Mobile bearing assembly having a non-planar interface|
|US8147557||Mar 30, 2007||Apr 3, 2012||Depuy Products, Inc.||Mobile bearing insert having offset dwell point|
|US8147558||Mar 17, 2008||Apr 3, 2012||Depuy Products, Inc.||Mobile bearing assembly having multiple articulation interfaces|
|US8152856||Mar 29, 2010||Apr 10, 2012||Nobel Biocare Ab (Publ.)||Layer arranged on implant for bone or tissue structure, such an implant, and a method for application of the layer|
|US8167954||Nov 4, 2008||May 1, 2012||Consensus Orthopedics, Inc.||Implant with composite coating|
|US8172897||Jun 28, 2004||May 8, 2012||Advanced Cardiovascular Systems, Inc.||Polymer and metal composite implantable medical devices|
|US8182541||Apr 9, 2009||May 22, 2012||Depuy Products, Inc.||Extended articulation orthopaedic implant|
|US8187335||Jun 30, 2008||May 29, 2012||Depuy Products, Inc.||Posterior stabilized orthopaedic knee prosthesis having controlled condylar curvature|
|US8191760||Feb 15, 2011||Jun 5, 2012||Zimmer Technology, Inc.||Method for attaching porous metal layer to a metal substrate|
|US8192498||Jun 30, 2008||Jun 5, 2012||Depuy Products, Inc.||Posterior cructiate-retaining orthopaedic knee prosthesis having controlled condylar curvature|
|US8197550||Sep 14, 2009||Jun 12, 2012||Biomet Manufacturing Corp.||Method and apparatus for use of porous implants|
|US8206387||Apr 21, 2011||Jun 26, 2012||Michelson Gary K||Interbody spinal implant inductively coupled to an external power supply|
|US8206451||Jun 30, 2008||Jun 26, 2012||Depuy Products, Inc.||Posterior stabilized orthopaedic prosthesis|
|US8211113||Jun 21, 2002||Jul 3, 2012||Depuy Products, Inc.||Prosthesis cutting guide, cutting tool and method|
|US8221499||Jan 25, 1999||Jul 17, 2012||Biomet 3I, Llc||Infection-blocking dental implant|
|US8226652||Nov 14, 2011||Jul 24, 2012||Warsaw Orthopedic, Inc.||Threaded frusto-conical spinal implants|
|US8231683||Dec 8, 2009||Jul 31, 2012||Depuy Products, Inc.||Shoulder prosthesis assembly having glenoid rim replacement structure|
|US8234097||Feb 24, 2010||Jul 31, 2012||Conformis, Inc.||Automated systems for manufacturing patient-specific orthopedic implants and instrumentation|
|US8236061||Jun 19, 2009||Aug 7, 2012||Depuy Products, Inc.||Orthopaedic knee prosthesis having controlled condylar curvature|
|US8241365||Dec 23, 2008||Aug 14, 2012||Depuy Products, Inc.||Shoulder prosthesis with vault-filling structure having bone-sparing configuration|
|US8251700||May 12, 2004||Aug 28, 2012||Biomet 3I, Llc||Surface treatment process for implants made of titanium alloy|
|US8251997||Nov 29, 2011||Aug 28, 2012||Warsaw Orthopedic, Inc.||Method for inserting an artificial implant between two adjacent vertebrae along a coronal plane|
|US8257391||Feb 7, 2011||Sep 4, 2012||Tyco Healthcare Group Lp||Annular support structures|
|US8265730||Jun 15, 2001||Sep 11, 2012||The Board Of Trustees Of The Leland Stanford Junior University||Assessing the condition of a joint and preventing damage|
|US8266780||Feb 27, 2008||Sep 18, 2012||Biomet Manufacturing Corp.||Method and apparatus for use of porous implants|
|US8277510||Oct 20, 2011||Oct 2, 2012||Kleiner Intellectual Property, Llc||Tools and methods for spinal fusion|
|US8282649||Oct 13, 2009||Oct 9, 2012||Depuy Products, Inc.||Extended articulation orthopaedic implant|
|US8292960||May 16, 2012||Oct 23, 2012||Kleiner Intellectual Property, Llc||Spinal fusion cage with removable planar elements|
|US8292967||Dec 5, 2005||Oct 23, 2012||Biomet Manufacturing Corp.||Method and apparatus for use of porous implants|
|US8306601||Aug 13, 2011||Nov 6, 2012||The Board Of Trustees Of The Leland Stanford Junior University||Assessing the condition of a joint and devising treatment|
|US8308809||Dec 1, 2008||Nov 13, 2012||Depuy International Limited||Method of implanting an implant including bone abrasion|
|US8323348 *||Feb 22, 2005||Dec 4, 2012||Taiyen Biotech Co., Ltd.||Bone implants|
|US8328874||Mar 17, 2008||Dec 11, 2012||Depuy Products, Inc.||Mobile bearing assembly|
|US8337501||May 10, 2010||Dec 25, 2012||Conformis, Inc.||Patient selectable joint arthroplasty devices and surgical tools|
|US8337507||Dec 22, 2008||Dec 25, 2012||Conformis, Inc.||Methods and compositions for articular repair|
|US8343218||Dec 22, 2008||Jan 1, 2013||Conformis, Inc.||Methods and compositions for articular repair|
|US8353909||Apr 25, 2006||Jan 15, 2013||Warsaw Orthopedic, Inc.||Surgical instrument for distracting a spinal disc space|
|US8361161 *||May 8, 2009||Jan 29, 2013||Fondel Finance B.V.||Kit and method for fixating a prosthesis or part thereof and/or filling osseous defects|
|US8361380||Feb 7, 2011||Jan 29, 2013||Biomet Manufacturing Corp.||Method for forming porous metal implants|
|US8366713||Mar 31, 2003||Feb 5, 2013||Depuy Products, Inc.||Arthroplasty instruments and associated method|
|US8366748||Dec 7, 2009||Feb 5, 2013||Kleiner Jeffrey||Apparatus and method of spinal implant and fusion|
|US8366771||May 10, 2010||Feb 5, 2013||Conformis, Inc.||Surgical tools facilitating increased accuracy, speed and simplicity in performing joint arthroplasty|
|US8369926||Jan 31, 2011||Feb 5, 2013||The Board Of Trustees Of The Leland Stanford Junior University||Assessing the condition of a joint and devising treatment|
|US8377129||Oct 27, 2009||Feb 19, 2013||Conformis, Inc.||Joint arthroplasty devices and surgical tools|
|US8383033||Oct 8, 2009||Feb 26, 2013||Biomet Manufacturing Corp.||Method of bonding porous metal to metal substrates|
|US8399619||Jun 30, 2006||Mar 19, 2013||Warsaw Orthopedic, Inc.||Injectable collagen material|
|US8409292||May 17, 2011||Apr 2, 2013||Warsaw Orthopedic, Inc.||Spinal fusion implant|
|US8439926||Mar 5, 2009||May 14, 2013||Conformis, Inc.||Patient selectable joint arthroplasty devices and surgical tools|
|US8444646||Apr 9, 2009||May 21, 2013||Depuy Products, Inc.||Bone preparation tool kit and associated method|
|US8460304||Oct 27, 2009||Jun 11, 2013||Conformis, Inc.||Joint arthroplasty devices and surgical tools|
|US8465548||Nov 24, 2010||Jun 18, 2013||DePuy Synthes Products, LLC||Modular glenoid prosthesis|
|US8475505||Aug 13, 2009||Jul 2, 2013||Smed-Ta/Td, Llc||Orthopaedic screws|
|US8475536||Jan 29, 2010||Jul 2, 2013||DePuy Synthes Products, LLC||Methods and devices for implants with improved cement adhesion|
|US8480750||Nov 24, 2010||Jul 9, 2013||DePuy Synthes Products, LLC||Modular glenoid prosthesis|
|US8480754||Feb 25, 2010||Jul 9, 2013||Conformis, Inc.||Patient-adapted and improved articular implants, designs and related guide tools|
|US8491596||Mar 9, 2009||Jul 23, 2013||Depuy Products, Inc.||Method for removal of bone|
|US8500740||Apr 16, 2010||Aug 6, 2013||Conformis, Inc.||Patient-specific joint arthroplasty devices for ligament repair|
|US8506645||Sep 20, 2010||Aug 13, 2013||Zimmer, Inc.||Tibial augments for use with knee joint prostheses|
|US8529630||Sep 24, 2012||Sep 10, 2013||Conformis, Inc.||Patient selectable joint arthroplasty devices and surgical tools|
|US8535385||Aug 8, 2011||Sep 17, 2013||Zimmer, Inc.||Prosthetic implant support structure|
|US8545506||Oct 30, 2009||Oct 1, 2013||DePuy Synthes Products, LLC||Cutting guide for use with an extended articulation orthopaedic implant|
|US8545507||May 2, 2011||Oct 1, 2013||DePuy Synthes Products, LLC||Prosthesis removal cutting guide, cutting tool and method|
|US8545569||Jan 5, 2004||Oct 1, 2013||Conformis, Inc.||Patient selectable knee arthroplasty devices|
|US8551099||May 10, 2010||Oct 8, 2013||Conformis, Inc.||Surgical tools for arthroplasty|
|US8551102||Sep 24, 2012||Oct 8, 2013||Conformis, Inc.||Joint arthroplasty devices and surgical tools|
|US8551103||Sep 24, 2012||Oct 8, 2013||Conformis, Inc.||Joint arthroplasty devices and surgical tools|
|US8551138||Aug 14, 2012||Oct 8, 2013||Covidien Lp||Annular support structures|
|US8551169||Sep 24, 2012||Oct 8, 2013||Conformis, Inc.||Joint arthroplasty devices and surgical tools|
|US8551181||Feb 27, 2012||Oct 8, 2013||Biomet Manufacturing, Llc||Method and apparatus for acetabular reconstruction|
|US8556906||Sep 24, 2012||Oct 15, 2013||Conformis, Inc.||Joint arthroplasty devices and surgical tools|
|US8556907||Sep 24, 2012||Oct 15, 2013||Conformis, Inc.||Joint arthroplasty devices and surgical tools|
|US8556980||Dec 17, 2010||Oct 15, 2013||DePuy Synthes Products, LLC||Glenoid augment and associated method|
|US8556983||Mar 9, 2011||Oct 15, 2013||Conformis, Inc.||Patient-adapted and improved orthopedic implants, designs and related tools|
|US8561278||Sep 24, 2012||Oct 22, 2013||Conformis, Inc.||Joint arthroplasty devices and surgical tools|
|US8562611||Sep 24, 2012||Oct 22, 2013||Conformis, Inc.||Joint arthroplasty devices and surgical tools|
|US8562618||Sep 24, 2012||Oct 22, 2013||Conformis, Inc.||Joint arthroplasty devices and surgical tools|
|US8568479||Sep 24, 2012||Oct 29, 2013||Conformis, Inc.||Joint arthroplasty devices and surgical tools|
|US8568480||Sep 24, 2012||Oct 29, 2013||Conformis, Inc.||Joint arthroplasty devices and surgical tools|
|US8585708||May 11, 2010||Nov 19, 2013||Conformis, Inc.||Patient selectable joint arthroplasty devices and surgical tools|
|US8586125||Sep 16, 2010||Nov 19, 2013||Advanced Cardiovascular Systems, Inc.||Thermal treatment of an implantable medical device|
|US8602290||Apr 22, 2011||Dec 10, 2013||Zimmer, Inc.||Method for bonding a tantalum structure to a cobalt-alloy substrate|
|US8608049||Oct 10, 2007||Dec 17, 2013||Zimmer, Inc.||Method for bonding a tantalum structure to a cobalt-alloy substrate|
|US8617172||Jul 20, 2012||Dec 31, 2013||Conformis, Inc.||Joint arthroplasty devices and surgical tools|
|US8617242||Feb 14, 2008||Dec 31, 2013||Conformis, Inc.||Implant device and method for manufacture|
|US8623026||Aug 10, 2011||Jan 7, 2014||Conformis, Inc.||Patient selectable joint arthroplasty devices and surgical tools incorporating anatomical relief|
|US8632600||Oct 14, 2010||Jan 21, 2014||Depuy (Ireland)||Prosthesis with modular extensions|
|US8632604 *||Oct 20, 2010||Jan 21, 2014||Depuy International Limited||Medical implant device|
|US8634617||Dec 6, 2011||Jan 21, 2014||Conformis, Inc.||Methods for determining meniscal size and shape and for devising treatment|
|US8641716||Jul 19, 2012||Feb 4, 2014||Conformis, Inc.||Joint arthroplasty devices and surgical tools|
|US8652154||Dec 28, 2006||Feb 18, 2014||Orthovita, Inc.||Non-resorbable implantable guides|
|US8657827||Nov 22, 2011||Feb 25, 2014||Conformis, Inc.||Surgical tools for arthroplasty|
|US8673015||Sep 21, 2009||Mar 18, 2014||DePuy Synthes Products, LLC||Concave resurfacing prosthesis|
|US8673018||Feb 1, 2011||Mar 18, 2014||AMx Tek LLC||Methods of using water-soluble inorganic compounds for implants|
|US8679118||Jul 23, 2012||Mar 25, 2014||Warsaw Orthopedic, Inc.||Spinal implants|
|US8682052||Mar 5, 2009||Mar 25, 2014||Conformis, Inc.||Implants for altering wear patterns of articular surfaces|
|US8685031||Jul 22, 2013||Apr 1, 2014||Spinal Surgical Strategies, Llc||Bone graft delivery system|
|US8690945||May 11, 2010||Apr 8, 2014||Conformis, Inc.||Patient selectable knee arthroplasty devices|
|US8696759||Apr 15, 2009||Apr 15, 2014||DePuy Synthes Products, LLC||Methods and devices for implants with calcium phosphate|
|US8702767||May 16, 2013||Apr 22, 2014||Smed-Ta/Td, Llc||Orthopaedic Screws|
|US8709088||Nov 22, 2013||Apr 29, 2014||Spinal Surgical Strategies, Llc||Fusion cage with combined biological delivery system|
|US8709089||May 3, 2010||Apr 29, 2014||Conformis, Inc.||Minimally invasive joint implant with 3-dimensional geometry matching the articular surfaces|
|US8715355||Oct 22, 2012||May 6, 2014||Nuvasive, Inc.||Spinal fusion cage with removable planar elements|
|US8715359||Oct 14, 2010||May 6, 2014||Depuy (Ireland)||Prosthesis for cemented fixation and method for making the prosthesis|
|US8727203||Sep 16, 2010||May 20, 2014||Howmedica Osteonics Corp.||Methods for manufacturing porous orthopaedic implants|
|US8728168||Nov 15, 2010||May 20, 2014||Zimmer, Inc.||Prosthetic implant support structure|
|US8734447||Jun 27, 2000||May 27, 2014||Warsaw Orthopedic, Inc.||Apparatus and method of inserting spinal implants|
|US8734522||Jun 20, 2012||May 27, 2014||Depuy (Ireland)||Posterior stabilized orthopaedic prosthesis|
|US8735773||Jun 10, 2011||May 27, 2014||Conformis, Inc.||Implant device and method for manufacture|
|US8758344||Aug 28, 2012||Jun 24, 2014||Warsaw Orthopedic, Inc.||Spinal implant and instruments|
|US8764836||Mar 18, 2011||Jul 1, 2014||Lieven de Wilde||Circular glenoid method for shoulder arthroplasty|
|US8764841||Mar 17, 2008||Jul 1, 2014||DePuy Synthes Products, LLC||Mobile bearing assembly having a closed track|
|US8768028||May 11, 2010||Jul 1, 2014||Conformis, Inc.||Methods and compositions for articular repair|
|US8771354||Oct 26, 2011||Jul 8, 2014||George J. Picha||Hard-tissue implant|
|US8771361 *||Sep 24, 2008||Jul 8, 2014||Nobel Biocare Services Ag||Arrangement for increasing the stress resistance of implants and one such implant|
|US8771365||Jun 23, 2010||Jul 8, 2014||Conformis, Inc.||Patient-adapted and improved orthopedic implants, designs, and related tools|
|US8784496||Jun 4, 2012||Jul 22, 2014||Depuy (Ireland)||Orthopaedic knee prosthesis having controlled condylar curvature|
|US8790350||Feb 18, 2011||Jul 29, 2014||DePuy Synthes Products, LLC||Instrument for preparing an implant support surface and associated method|
|US8795380||Jul 2, 2012||Aug 5, 2014||Depuy (Ireland)||Orthopaedic knee prosthesis having controlled condylar curvature|
|US8808303||Dec 19, 2011||Aug 19, 2014||Microport Orthopedics Holdings Inc.||Orthopedic surgical guide|
|US8808305||Oct 1, 2012||Aug 19, 2014||Jeffrey B. Kleiner||Spinal fusion cage system with inserter|
|US8814943||May 1, 2013||Aug 26, 2014||DePuy Synthes Products,LLC||Bone preparation tool kit and associated method|
|US8814978||Jan 10, 2013||Aug 26, 2014||Biomet Manufacturing, Llc||Method and apparatus for forming porous metal implants|
|US8828086||Jun 30, 2008||Sep 9, 2014||Depuy (Ireland)||Orthopaedic femoral component having controlled condylar curvature|
|US8834575||May 28, 2012||Sep 16, 2014||Depuy (Ireland)||Posterior stabilized orthopaedic knee prosthesis having controlled condylar curvature|
|US8858634||Nov 4, 2009||Oct 14, 2014||Mayo Foundation For Medical Education And Research||Soft tissue attachment device|
|US8862202||Sep 10, 2012||Oct 14, 2014||The Board Of Trustees Of The Leland Stanford Junior University||Assessing the condition of a joint and preventing damage|
|US8864826 *||Feb 25, 2011||Oct 21, 2014||Limacorporate Spa||Integrated prosthetic element|
|US8870882||Jan 30, 2013||Oct 28, 2014||Jeffrey KLEINER||Apparatus and method of spinal implant and fusion|
|US8871142||May 21, 2009||Oct 28, 2014||DePuy Synthes Products, LLC||Implants with roughened surfaces|
|US8882776||Aug 29, 2013||Nov 11, 2014||DePuy Synthes Products, LLC||Extended articulation orthopaedic implant|
|US8882847||Nov 24, 2004||Nov 11, 2014||Conformis, Inc.||Patient selectable knee joint arthroplasty devices|
|US8894717||Apr 9, 2010||Nov 25, 2014||Depuy International Limited||Surgical prostheses|
|US8900317||May 18, 2012||Dec 2, 2014||Zimmer, Inc.||Stabilizing prosthesis support structure|
|US8906028||Sep 20, 2010||Dec 9, 2014||Spinal Surgical Strategies, Llc||Bone graft delivery device and method of using the same|
|US8906107||Nov 11, 2011||Dec 9, 2014||Conformis, Inc.||Patient-adapted and improved orthopedic implants, designs and related tools|
|US8932363||Nov 7, 2003||Jan 13, 2015||Conformis, Inc.||Methods for determining meniscal size and shape and for devising treatment|
|US20050177162 *||Jan 21, 2005||Aug 11, 2005||Fondel Finance B.V.||Made of a biocompatible material such as titanium and are screwed into bone by fixing screws; sponge-like biocompatible material enclosed between the bone and the surface|
|US20090306673 *||May 8, 2009||Dec 10, 2009||Fondel Finance B.V.||Kit and method for fixating a prosthesis or part thereof and/or filling osseous defects|
|US20110008754 *||Jul 10, 2009||Jan 13, 2011||Bassett Jeffrey A||Patient-Specific Implants With Improved Osseointegration|
|US20120253468 *||Oct 20, 2010||Oct 4, 2012||Depuy International Limited||Medical implant device|
|US20130006354 *||Feb 25, 2011||Jan 3, 2013||Limacorporate Spa||Integrated prosthetic element|
|US20130013081 *||Sep 14, 2012||Jan 10, 2013||Astra Tech Ab||Nanosurface|
|USRE43282||Aug 19, 2008||Mar 27, 2012||The Board Of Trustees Of The Leland Stanford Junior University||Assessing the condition of a joint and devising treatment|
|DE2620631A1 *||May 10, 1976||Nov 11, 1976||David C Macgregor||Kardiovaskulaere prosthetische vorrichtungen und implantate mit poroesen systemen|
|DE3445731A1 *||Dec 14, 1984||Jun 19, 1986||Draenert Klaus||Material and use thereof|
|DE3918967A1 *||Jun 9, 1989||Dec 21, 1989||Haruyuki Kawahara||Rahmenloses und kernloses poroeses enossales implantat|
|DE102005052354A1 *||Nov 2, 2005||May 3, 2007||Plus Orthopedics Ag||Open-pore biocompatible surface layer for application to an implant comprises a coherent pore network and has a defined surface area|
|EP0075378A1 *||Apr 14, 1982||Mar 30, 1983||Crucible Materials Corporation||Prosthesis device and method of manufacture|
|EP0162604A1 *||Apr 25, 1985||Nov 27, 1985||Minnesota Mining And Manufacturing Company||Implant with attachment surface|
|EP0511686A2 *||Dec 16, 1985||Nov 4, 1992||DRAENERT, Klaus, Dr.med.||Artificial bone and method for making it|
|EP0875217A2 *||Apr 15, 1998||Nov 4, 1998||Advanced Cardiovascular Systems, Inc.||Method of manufacturing a medicated porous metal prosthesis|
|EP0875218A2 *||Apr 15, 1998||Nov 4, 1998||Advanced Cardiovascular Systems, Inc.||Porous medicated stent|
|EP1216668A2||Dec 14, 2001||Jun 26, 2002||Depuy Orthopaedics, Inc.||Prosthesis with feature aligned to trabeculae|
|EP1338256A1||Feb 26, 2003||Aug 27, 2003||DePuy Products, Inc.||Acetabular component with removable screw hole plugs|
|EP1449544A1 *||Feb 24, 2004||Aug 25, 2004||Depuy Products, Inc.||Metallic implants having roughened surfaces and methods for producing the same|
|EP1464305A2||Mar 31, 2004||Oct 6, 2004||Depuy Products, Inc.||Orthopaedic joint replacement prosthesis|
|EP1470802A1||Mar 30, 2004||Oct 27, 2004||Depuy Products, Inc.||Articulating surface replacement prosthesis|
|EP1488760A2||Nov 30, 1995||Dec 22, 2004||Implant Innovations, Inc.||Implant surface preparation|
|EP1527754A1 *||Apr 15, 1998||May 4, 2005||Advanced Cardiovascular Systems, Inc.||Porous medicated stent|
|EP1639966A1||Sep 21, 2005||Mar 29, 2006||DePuy Products, Inc.||Glenoid augment|
|EP1639967A1||Sep 21, 2005||Mar 29, 2006||DePuy Products, Inc.||Modular glenoid prosthesis|
|EP1711128A2 *||Jan 18, 2005||Oct 18, 2006||Osteobiologics, Inc.||Bone-tendon-bone implant|
|EP1958650A1 *||Dec 5, 2006||Aug 20, 2008||Mitsubishi Materials Corporation||Medical device and method of modifying the surface of medical device|
|EP1997524A1||Dec 29, 2007||Dec 3, 2008||DePuy Products, Inc.||Sintered coatings for implantable prosthesis|
|EP2008622A1||Jun 24, 2008||Dec 31, 2008||DePuy Products, Inc.||Osteogenic prostheses|
|EP2011903A2||Jul 5, 2008||Jan 7, 2009||DePuy Products, Inc.||Etching solution and method of its manufacturing as well as method of etching metal surfaces and microtextured implants made using such a method|
|EP2143823A2||Jun 29, 2009||Jan 13, 2010||DePuy Products, Inc.||Open-celled metal implants with roughened surfaces|
|EP2226408A1||Feb 11, 2010||Sep 8, 2010||DePuy Products, Inc.||Rough porous constructs|
|EP2241288A1||Apr 14, 2010||Oct 20, 2010||DePuy Products, Inc.||Surface textured titanium-containing articles|
|EP2251046A2||Apr 14, 2010||Nov 17, 2010||DePuy Products, Inc.||Nanotextured cobalt-chromium alloy articles|
|EP2292188A2||Nov 25, 2003||Mar 9, 2011||Conformis, Inc.||Patient selectable surgical tools|
|EP2292189A2||Nov 25, 2003||Mar 9, 2011||Conformis, Inc.||Patient selectable surgical tools|
|EP2316387A1||Oct 12, 2010||May 4, 2011||DePuy Products, Inc.||Cutting guide for use in a joint replacement procedure|
|EP2324799A2||Nov 22, 2005||May 25, 2011||Conformis, Inc.||Patient selectable knee joint arthroplasty devices|
|EP2335654A1||Nov 24, 2004||Jun 22, 2011||Conformis, Inc.||Patient selectable knee joint arthoplasty devices|
|EP2397110A1||Jun 24, 2004||Dec 21, 2011||BIEDERMANN MOTECH GmbH||Tissue integration design for seamless implant fixation|
|EP2623050A1||Jan 16, 2013||Aug 7, 2013||DePuy Products, Inc.||Instrument for use in shoulder arthroplasty|
|EP2649951A2||Feb 6, 2007||Oct 16, 2013||ConforMIS, Inc.||Patient selectable joint arthroplasty devices and surgical tools|
|EP2671520A2||Feb 6, 2007||Dec 11, 2013||ConforMIS, Inc.||Patient selectable joint arthroplasty devices and surgical tools|
|EP2671521A2||Feb 6, 2007||Dec 11, 2013||ConforMIS, Inc.||Patient selectable joint arthroplasty devices and surgical tools|
|EP2671522A2||Feb 6, 2007||Dec 11, 2013||ConforMIS, Inc.||Patient selectable joint arthroplasty devices and surgical tools|
|EP2710967A2||Feb 6, 2007||Mar 26, 2014||ConforMIS, Inc.||Patient selectable joint arthroplasty devices and surgical tools|
|WO1983000282A1 *||Jul 23, 1982||Feb 3, 1983||Battelle Development Corp||Production of porous coating on a prosthesis|
|WO1983002555A1 *||Jan 21, 1983||Aug 4, 1983||Us Medical Corp||Prosthesis fixation to bone|
|WO1986003667A1 *||Dec 16, 1985||Jul 3, 1986||Klaus Draenert||Occlusion device made of surgical material|
|WO1986003671A1 *||Dec 16, 1985||Jul 3, 1986||Klaus Draenert||Bone replacement material and utilization thereof|
|WO1989000413A1 *||Jul 20, 1988||Jan 26, 1989||Kevin R Stone||Prosthetic meniscus|
|WO1994028826A1 *||May 17, 1994||Dec 22, 1994||Depuy Inc||Prosthesis with highly convoluted surface|
|WO1995032623A1 *||May 23, 1995||Dec 7, 1995||Regen Biolog Inc||Meniscal augmentation device|
|WO1996016611A1||Nov 30, 1995||Jun 6, 1996||Implant Innovations Inc||Implant surface preparation|
|WO1997021393A1||Dec 8, 1995||Jun 19, 1997||Calcitek Inc||Dental implant having multiple tectured surfaces|
|WO1998048077A1 *||Feb 27, 1998||Oct 29, 1998||Hans Peter Buchkremer||Thin, fine pored metal layer|
|WO1999054524A1 *||Apr 17, 1998||Oct 28, 1999||Gkn Sinter Metals Filters Gmbh||Method for producing an openly porous sintered metal film|
|WO1999058167A1 *||Apr 16, 1999||Nov 18, 1999||Robert R Aharonov||Implant with composite coating|
|WO2002049548A1 *||Jan 15, 2001||Jun 27, 2002||Yuichi Higuchi||Indwelling instrument|
|WO2002092881A2 *||Apr 5, 2002||Nov 21, 2002||Gkn Sinter Metals Gmbh||Method for producing at least partially coated bodies with a coating consisting of a sinterable material|
|WO2003013396A1 *||Aug 12, 2002||Feb 20, 2003||Stanmore Implants Worldwide||Surgical implant|
|WO2004002544A1 *||May 27, 2003||Jan 8, 2004||Reto Lerf||Open-pored metal coating for joint replacement implants and method for production thereof|
|WO2007051519A2||Oct 12, 2006||May 10, 2007||Plus Orthopedics Ag||Open-cell biocompatible coating for an implant, method for the production thereof, and use thereof|
|WO2010122281A1 *||Apr 9, 2010||Oct 28, 2010||Depuy International Limited||Surgical prostheses|
|WO2011004217A1 *||Jul 7, 2009||Jan 13, 2011||Eurocoating S.P.A.||Process for depositing a coating on metal or non- metal items, and item obtained therefrom|
|WO2011004334A2 *||Jul 7, 2010||Jan 13, 2011||Eurocoating S.P.A.||Process and apparatus for depositing a coating on items, and item obtained from said process|
|WO2011048138A1||Oct 20, 2010||Apr 28, 2011||Depuy International Limited||A medical implant device|
|WO2012153092A1||Apr 18, 2012||Nov 15, 2012||Finsbury (Development) Ltd||A package|
| || |
|U.S. Classification||623/23.55, 433/173|
|International Classification||A61F2/36, A61F2/30, A61F2/28, A61L27/30, A61F2/32, A61K6/04, B22F7/00, A61F2/08, C23C24/08, A61F2/00|
|Cooperative Classification||A61F2310/00029, A61F2/36, A61F2250/0023, A61F2/32, A61F2310/00413, A61F2002/30011, A61F2/30767, B22F7/002, A61F2002/30769, A61F2310/00017, A61F2002/30968, A61F2/0811, A61F2/2875, A61F2310/00407, A61F2/30, A61L27/306, A61F2310/00023, C23C24/087, A61F2310/00401|
|European Classification||C23C24/08B2B, A61F2/36, B22F7/00B, A61F2/30L, A61L27/30R, A61F2/30|