|Publication number||US3858581 A|
|Publication date||Jan 7, 1975|
|Filing date||Jul 2, 1973|
|Priority date||Jul 2, 1973|
|Also published as||CA1041394A, CA1041394A1|
|Publication number||US 3858581 A, US 3858581A, US-A-3858581, US3858581 A, US3858581A|
|Original Assignee||Dean Kamen|
|Export Citation||BiBTeX, EndNote, RefMan|
|Patent Citations (5), Referenced by (164), Classifications (6), Legal Events (2)|
|External Links: USPTO, USPTO Assignment, Espacenet|
United States Patent 11 Kamen Jan. 7, 1975 MEDICATION INJECTION DEVICE Primary ExaminerDalton L. Truluck  Inventor: Dean Kamen, 99 Bulsar Rd., Attorney Agent or F'rm Bauer & Amer Rockville Centre, NY. 11570 221 Filed: July 2, 1973 AB TRACT [2l] Appl. No.: 375,955 A medication-administering device controlled for repetitive delivery, by intravenous injection or otherwise, of predetermined syringe volumes of said medi-  US. Cl. 128/218 A, l28/DIG. l cation at present time intervals, wherein the Syringe  hit. Cl A6lm 5/20 plunger medication injection Stroke is achieved using  Fleld of Search 128/2 218 R a powering motor, and the control exercised over the 128/218 214 214 236 mode of operation of the device is related to the rotational traverses of said motor. This minimizes non-  References C'ted uniform performance and other shortcomings which UNITED STAT S PA NTS characterize prior art medication injection devices in 2,602,446 7/1952 Glass etal. 128/218 A hich the performance of the powering motors are 2,627,270 2/1953 Glass l28/2l8 A vulnerable to variances due to varying line voltage, 3,091,239 5/1963 Moeller 128/214 F changing work loads (i.e. medication with different HObbS A viscosities) and the 3,701,345 10/1972 Heilman et al 128/2 R 5 Claims, 6 Drawing Figures MEDICATION INJECTION DEVICE The present invention relates to improvements in a medication injection device, and more particularly to an automatic medication-injecting or administering device readily capable of dispensing medication in accordance with any selected schedule of successive intervals of operation and non-operation of a syringedriving or powering motor.
Motor driven syringes for medication injection service are already known, being described and illustrated in U.S. Pat. Nos. 3,456,649 and 3,623,474, as well as in other patents. None of these prior art devices are readily capable of repetitive deliveries of selected volumes of medication, i.e., of delivering 2 ccs of a medication every 2 hours for an 8-hour period, thereby performing four such deliveries, or otherwise operating on a schedule requiring repetition. Instead, each such prior art device is limited in-service to a one-time delivery of a seclected volume of medication, during which a motor merely drives the syringe plunger entirely through a selected linear displacement causing exiting flow of the medication from the syringe barrel.
Moreover, any attempt to achieve repetitive performance from any of the aforesaid prior art devices would be extremely difficult because of the limited controls that they can accommodate. In the syringe device of U.S Pat. No. 3,456,649, for example, the mechanical components partake of linear movement during its operation and thus, to achieve repetitive service, there would be required limit switches or the like, adjustable in position along the path of said linear movement, to start and stop operation of the device as a function of engagement or physical contact that is established with these limit switches. This concept of control is expensive and complicated, and also vulnerable to malfunction in the event of failure to establish operating contact between a moving part and a control switch. This, in turn, could result in the delivery or administration of an overdose of medication, thereby endangering the patients health.
Broadly, it is an object of the present invention to provide an improved medication injection device overcoming the foregoing and other shortcomings of the prior art. Specifically, it is an object to provide a motor driven syringe for medication injection or other delivery to a patient which is readily capable of repetitive service, is characterized by uniform performance in each said repeated cycle, and has a high degree of reliability in achieving these performance requirements.
A medication injection device demonstrating objects and advantages of the present invention includes a motor operated in rotation and operatively arranged to cause linear displacement, and thus a medicationinjection stroke, in a syringe plunger, a pulse generating means effective to emit a pulse each rotational traverse of the motor during which said syringe plunger partakes of a known, uniform movement in its said stroke, and a pulse-counting means electrically connected to receive the transmission of each aforesaid pulse and operatively connected to cause the commencement of the operation of said syringe-driving motor and the continued operation thereof for the duration of the transmission thereto of a selected number of said pulses, whereby medication-dispensing service of said device is controlled as a function of the number of rotational traverses of said motor as counted by said pulse-counting means.
The above brief description, as well as further objects, features and advantages of the present invention, will be more fully appreciated by reference to the following detailed description of a presently preferred, but nonetheless illustrative embodiment in accordance with the present invention, when taken in conjunction with the accompanying drawings, wherein:
FIG. 1 is a perspective view of a medication injection device according to the present invention;
FIG. 2 is a plan view of the device illustrating further structural features thereof, and also illustrating how the volume of the medication to be dispensed is related to an operating parameter of the device, namely electrical pulses emitted during its operation;
FIG. 3 is a side elevational view, taken in longitudinal section, illustrating internal structural features;
FIG. 4 is an end elevational view, in section taken on line 4-4 of FIG. 3, illustrating structural features of a pulse generator used in the device hereof;
FIG. 5 is a partial plan view, in section taken on line 5-5 of FIG. 3, illustrating further structural features; and
FIG. 6 is a block diagram illustrating the electrical components used in controlling the operation of the mechanical components of the device hereof.
Reference is now made to the drawings, and in particular to FIGS. 1-3, which show the general organization of the mechanical parts of a medication injection device, generally designated 10, demonstrating objects and advantages of the present invention. As the name implies, the contemplated use of the device 10 is to achieve the intravenous injection of selected volumes of medication, dispensed from a syringe 12, according to a selected schedule. That is, there are many drugs which cannot be administered to a patient slowly and uniformly over a prolonged period, but rather must be administered within a prescribed comparatively short period, followed by a longer period, when it is not administered and the patients body has an opportunity to react to the administered drug. For example, there are certain blood anti-coagulants that are best administered frequently, but at intermittant intervals, in order to produce the desired effect on the blood. Device 10 can be most advantageously used for this purpose.
As will be described in detail herein, any selected volume of medication can be dispensed from the syringe 12 through tubing 15 having at its end, although not shown, a syringe needle or other implement connected for intravenous delivery of the medication into the patient. Moreover, as just noted, the time interval, during which a selected volume of the drug or medication, such as 1 cubic centimeter or cc", is to be delivered can be relatively short, e.g., in less than 1 minute, and the next administration of this same volume of medication can be arranged to occur in 2 hours, or after other such interval of time. Thus, assuming that syringe 12 is filled with 6 ccs of medication which has to be delivered I cc at a time every 2 hours, this is readily easy to achieve by proper setting of the controls of the device 10. Naturally, the values selected in the previous example can be modified, and the invention is no way intended to be limited thereto, since it can be just as easily arranged that 2 ccs of medication be administered every 6 hours, et cetera. The significance of the mode of operation of device 10 is that it is operational or effective to dispense medication in accordance with a selected schedule of successive intervals of operation and non-operation.
In the preferred form of device as illustrated in FIGS. 15, the same includes, as previously noted, a syringe 12 of the type having a plunger 14, the linear displacement of which dictates the amount of medication which is dispensed from the syringe chamber 12 through the tubing 15 to the patient. Arranged to cause linear displacement of the plunger 14 is an upstanding head 16 of a follower, generally designated 18, which, as best shown in FIG. 3, has a threaded member which is mounted, as at 20, on a lead screw 22 which is powered in rotation by a motor 24. That is, the motor 24 is operatively connected to power the lead screw 22 in rotation, said lead screw having threads 26 of of uniform pitch machined along its length and further being disposed substantially parallel .to the path of linear displacement of the plunger 14, in this instance being arranged below plunger 14 so that the pushing head 16 is readily adapted to be mounted on an upstanding rod 28 projected through a slot 30 in the top plate 32 of the device housing 34. An elastomeric closure 36 with a central slit 38 is appropriately mounted across the slot 30 to prevent dust or other contamination of the interior of the housing box 34.
Completing the construction of the follower 18, and as is well understood to prevent rotation thereof simultaneously with rotation of the lead screw 22, is a body element 40, the forward end of which is prevented from partaking of rotative movement by being projected, as at 42, through a bore or opening in a stationary depending mounting member 44 which also assists in supporting the previously noted motor 24. In operation, lead screw 22 is driven in rotation and the threaded member in meshing engagement therewith is therefore advanced along the length of the lead screw 22. Naturally, in one direction of rotation of lead screw 22 member 20 is advanced toward the motor 24, and in the opposite direction of rotation away from the motor 24. Head 16 has movements corresponding to the member 20, and one said direction of movement causes it, because of its pushing engagement as at 46 with the end of the plunger 14, to cause linear displacement of this plunger within the syringe barrel 12 which, in an obvious manner, results in the dispensing of medication in accordance with said linear displacement from the internal chamber of the syringe 12. To hold the syringe 12 against displacement while the plunger thereof is being operated by the follower head 16, a laterally extending lip 48, which normally functions as a finger grip, has a portion disposed in a holding recess 50 of a mounting plate 52 appropriately secured in place on the top plate 32. An L-shaped rod 54 functions as a clamp to hold the syringe barrel against the mounting plate 52 and, in turn, is held in place by a lock screw 56 which, upon threaded adjustment, engages the flattened surface 58 of the clamp 54.
Although the lead screw and follower drive arrangement has been used heretofore in producing linear displacement of a syringe plunger in automatic medication injection devices, in the device 10 hereof, the manner in which control is exercised over the operation of the lead screw and follower 22, 28, respectively, is unique and is not known in the prior art nor is it suggested therein. Specifically, this control consists of using the rotational traverses of the lead screw 22 as the measure of the duration that the powering motor 24 is operational. As a consequence, serious prior art shortcomings are overcome. For example, if the powering motor in a prior art device is permitted to operate for a selected interval of time, this still would result in non-uniform volumes of medication being dispensed since, during the selected interval of time of motor operation, there could be variations in the line voltage utilized to energize the motor 24. Also, the work load on the powering motor could be variable and this also would result in non-uniform volumes of medication being dispensed. Within any specified time interval, a prior art motor will cause the delivery of a greater volume of a less viscous medication than one with a greater viscosity, and thus to achieve uniform dispensing of medication with such a prior art device, it is necessary to make an adjustment in the control to account for the different viscosities of the medication being dispensed. Still further, after a prolonged period of use the bearings or other moving parts of a prior art device would experience wear that would in turn effect its operation during an interval of operation, and this variation in frictional resistance would also-result in nonuniform volumes of medication being dispensed. In sharp contrast to the foregoing, it is therefore one of the unique aspects of the device 10 hereof that the interval of operation of the powering motor 24 is related to the number of rotational traverses that occur in the lead screw 22, irrespective of the time that it takes to achieve these number of rotational traverses. Naturally, with each rotational traverse of the lead screw 22, member 20 is advanced a uniform amount dictated by the pitch of the uniform threads 26, and this uniform advancement of member 20 also occurs in the pushing head 16 and thus must, of necessity, also result in a uniform linear displacement in the syringe plunger 14.
At this point in the description, it is appropriate to indicate how the volume of medication to be dispensed during each application is related to the number of rotational traverses of the lead screw 22. As illustrated in FIG. 2, marked along one edge of the top plate 32, as along edge 60, is a scale, generally designated 62, which is laid out, starting from 0, in ascending numbers such that said numbers are located at distances from the starting point 0 which correspond to the distances of advancement that is produced by the uniform advance or thread pitch 26, that results from that number of rotational traverses in the lead screw 22. Thus, taking into account that with each rotational traverse of the lead screw 22, member 20 will move the pitch of each thread 26 thereon, it follows that the linear distance 64 will be achieved with 10 rotational traverses, and twice that distance with 20 rotational traverses, and so on. Further, assuming that it is desired to dispense 2 ccs of medication during each injection period, as clearly illustrated in FIG. 2, this will require approximately 27 rotational traverses since, by laying the syringe barrel l2 alongside the scale 62, a 2-cc volume as laid out on the barrel l2 spans the distance from the 0 point on the scale 62 to a point therealong, designated 65, which corresponds to point 27 of the scale. Assuming further that it is desired to dispense these 2 ccs of medication every 2 hours, there are two timing controls embodied in the device 10 which are appropriately set to provide the schedule of medication administration indicated. From what has already been described, it should be readily appreciated that medication is administered or delivered to the patient only during operation of the powering motor 24. The motoron timer, generally designated 66, includes, as best illustrated in FIG. 2, two control knobs or selectors 68 and 70, each being related to a circumferential display of numbers 72 from l to 10. In a manner which will be better understood subsequently, the 2 ccs of medication previously discussed which also, as previously discussed, is dispensed by 27 rotational traverses of the lead screw 22, as thus imposed on the mode of operation of the device by setting the selector 68 at numeral2 and selector 70 at numeral 7, the combined effect being a selection of 27 as the number of rotational traverses which will occur in the lead screw 22 during each interval of operation of the powering motor 24.
The other timing device, generally designated 74, is the one which controls or times the motor-off interval, this timer also including a selector 76 within a circumferential arrangement 78 of numbers from 1 to 10. In the example being used to illustrate the mode of operation of device 10, the interval of non-operation of the powering motor 24 is to be 2 hours between injections of the medication, and thus selector 76 is moved in proper relation to numeral 2 to provide this result. The manner in which this result is achieved will be explained subsequently.
Reference will now be had to FIGS. 4, 5, in conjunction with FIGS. l-3, to best explain how the operation of device 10 is controlled in accordance with the rotational traverses of the lead screw 22. Specifically, mounted on the end of the lead screw 22 remote from the powering motor 24 is a radially oriented striker 80 which is driven in rotation simultaneously with the lead screw 22. As illustrated best in FIG. 4, mounted adjacent the striker 80, and more particularly, in the path of the rotational traverse thereof, is a switch contact arm against which actual physical contact is made by the striker 80 during each rotational traverse. This physical contact or abuttment against the switch contact 82 results in actuation of the switch 84. More particularly, it will be understood that switch 84 is part of a pulse-generating circuit in that the actuation thereof is effective to complete this circuit and, in turn, cause the production and transmission of an electric pulse to a pulse-counting circuit which may be embodied on a printed circuit board 86 (see FIG. 3).
As will be explained in greater detail in connection with the circuit diagram of FIG. 6, the pulse-counting circuit 86 will be understood to be effective in causing the commencement of the operation of the powering motor 24 and in causing the continued operation thereof for the duration of the transmission to it of a selected number of said pulses, which in the example being discussed would amount to 27 pulses. This number of pulses or rotational traverses of the lead screw 22 will result, as already noted, in linear displacement of the syringe plunger 14 which will force out of the syringe barrel l2 2 ccs of medication.
On the 27th rotational traverse of the lead screw 22, the electrical control components of the device 10 are effective in causing three conditions of operation. The first is the resetting of the motor-on timer 66 at the 0 setting. The second is the termination of the operation of the powering motor 24. The third is the starting of the timing operation of the motor-off timer 74. As in the case of the motor-on timer 66, the timer 74 is also operated by the transmission to it of pulses and, in accordance with the example being discussed, will therefore receive whatever number of pulses generated, not by the rotation ofthe lead screw 22, but by an oscillator of some other source, but which corresponds to the passage of 2 hours of time, this being the time interval selected for non-operation of the motor 24.
At the expiration of this 2-hour time interval, the motor 24 will again commence its operation, and at that time striker 80, by virtue of actuating switch 84, will again cause a pulse-generating activity as a function of the rotational traverses of the lead screw 22 being powered in rotation by the motor 24. When 27 pulses are again transmitted or counted by the pulsecounting circuit 26, the operation of motor 24 which results in a medicine-injecting stroke in the syringe plunger 14 is again terminated. Ultimately, the final 2 ccs of medication is dispensed from the syringe barrel 12, thus requiring the refilling thereof. To signal this condition, and as best illustrated in FIG. 5, the follower body 40 has a laterally extending contact 88 which is arranged to actuate the limit switch 91 by physically abutting against the contact 92 thereof, thus indicating that the end of the medicine-injecting stroke 94 is reached.
In addition to the timing controls consisting of the motor-on timer 66 and motor-off timer 74, device 10 also includes a control which overrides these timing devices and which results in the injection of medicine, even if not in accordance with the selective schedule. This permits the injection of medicine or medication in emergency situations. The control itself includes an accessible push-button 96 which, when depressed, is electrically effective to immediately start operation of the powering motor 24, even if at that time the device 10 is under the control of the motor-off timer 74. Device 10 also includes an off-on master switch 98.
Also advantageously included as part of the controls for the device 10 is a visual signal in the form of a blinking light 100. Light 100 is energized by each pulse successively transmitted to the timers 66 and 78, and thus is effective in indicating operation of the device 10 dur ing both motor-on and motor-off intervals.
Completing the device 10, and as best illustrated in FIG. 3, is a safety device feature which disconnects the drive between the motor 24 and lead screw 22 in the event of successive buildup of pressure which is transmitted in a reverse direction through the tube 15 into the barrel chamber 12 and against the syringe plunger 14. This buildup of resistance pressure will of course be transmitted against the pushing head 16 and thus is manifested as a force tending to push lead screw 22 in a direction away from the motor 24. In response to this force, a clutch 136 of a shaft coupling 90 will break its driving connection between its driving and driven elements and thus result in discontinuation of the driving connection between the motor 24 and the lead screw 22. Clearance for this slight rearward movement of lead screw 22 is provided by compression of an internal spring 138 as a driving notch 140 in the end of the lead screw 22 moves relative to a driving pin 142. The notch and pin drive 140, 142 will be recognized as providing simultaneous driving rotation of the striker 80 as powering motor 24 drives lead screw 22 in rotation.
Reference is now made to FIG. 6 in which there is illustrated, in diagramatic form, an exemplary electronic circuit which will be understood to be laid out and otherwise appropriately embodied on the printed circuit board 86. Thecircuit of FIG. 6 will further be understood to function as the motor-on timer 66 and also as the motor-off timer 74, in both instances providing a timing function which utilizes and appropriately reacts to the transmission to it of an electronic pulse. In effect, this portion of the circuit of FIG. 6, generally designated 110, provides the pulse-counting service or function for the device 10 in the manner previously described. This function, in turn, could be powered by batteries or by line voltage. That is, the device 10 can be used in strapped position on the arm of the patient, in which instance it will be portable and operated by batteries (not shown). Alternatively, it can be used at bedside, in which instance it would be powered by an ordinary electrical source. Assuming the latter, the power fed into the unit operates an electric oscillator or pulse generator 112. This generator may be any one of several types, being generally a unit which reaches a selected peak voltage on a selected time basis and which emits a pulse. The output or pulse from the generator 112 is fed into the counting circuit 110. This counting circuit also could be any one of several socalled decade counting circuits readily available from major firms such as RCA or the like.
For present purposes, it is suffice to note that operation of a decade counter, such as that denominated First Pulse Counter and designaged 114 in FIG. 6, has 10 or more outputs identified by the numbering from to 10. The operation of the pulse counter 114 contemplates activation of each of these outputs in succession with each cycle of operation, and then a repeat of this cycle of operation. Accordingly, output 0 is first activated, then output 1, then output 2, et cetera. When output is activated, this completes an electrical connection to a second decade counter, designated Second Pulse Counter and identified by reference numeral 116, which experiences the same mode of operation just described in connection with counter 114. Meanwhile, the cycle of operation of counter 114 is repeated. In effect, therefore, it takes the completion of the succession of pulses through all of the 10 outputs of the first counter 114 to produce one pulse which is sent via conductor 118 to the succeeding counter 116. In this manner, any number of pulses can be counted, it being understood that any selected number of counters 114, 116 and the like can be electrically connected to each other so as to function as a timing device, the two units 114, 116 being used as the motor-on timer 66 to measure the interval of time during which the powering motor 24 of the injection device 10 is operative. Naturally, a greater number of these units would be used in cooperative relation to provide the motor-off timer 74.
Continuing with the illustrative example previously referred to, the selection of 27 pulses for the interval of operation of the powering motor 24 is thus achieved by arranging the selector 68 so that the wiper 120 thereof is electrically connected to output 2 of the second pulse counter 116 and that the selector 70, and more particularly the wiper 122 thereof, is electrically connected to the output 7 of the first pulse counter 114. While this may appear to be reversed, such arrangement provides for motor-on operation for an interval of 27 pulses. As already explained, to achieve energization of output 2 of the second pulse counter 116 requires the transmission to this counter of two pulses, each one of which, however, requires the energization or pulsing of all ten outputs of the first pulse counter 114, or in other words 20 pulses. Thus. when the first pulse counter 114 starts on its third successive cycle of counting operation and when output 7 is energized on the seventh transmitted pulse, this results in electrical connection to the two outputs 2 and 7 electrically connected to the selectors 68 and 70. This, in turn, completes a control circuit 124 which results in the transmission of a pulse to a motor-off switch 126 which results in termination of the powering operation of the motor 24. It also results in the transmission of a pulse via a conductor 128 to a starter circuit 131 for the motor-off timer 74 which results in the start in operation of this timer.
It will of course be understood that the wipers associated with the selectors 68 and 70 could have been rotated to make electrical connection with other outputs other than the specific outputs indicated. This is illustrated in FIG. 6 wherein the range of wiper location is diagramatically illustrated by the path of wiper movement 130.
It is also illustrated in FIG. 6 that pulse generator 112 also transmits a pulse via conductor 132 to a reset control circuit 134 which is effective to reset to 0 the motor-off timer 74 at the end of each interval of nonoperation of motor 24. This may be done in any number of ways. One way, for example, is to have the last pulse of this interval operate a flip-flop switch. Such switch is a standard part readily purchased in the open market from such firms as RCA and the like and operates, as generally noted, such that upon activation by said last pulse, it completes the circuit to the motor and at the same time resets the counting circuit at its original 0 setting. As a result, when the motor operation is terminated, the counting circuit 110 is in condition to start counting from 0 again.
It should be readily appreciated from the description of the mechanical components of the device 10 that the pulse generator 112 during the interval of operation of the motor 24, is controlled in its pulse-emitting function by the striker which, upon physical contact with the switch 84 during each rotational traverse of the lead screw 22, produces a pulse which is counted by the motor-on timer 66. However, during non-operation of the powering motor 24, the pulse generator 112 is operated as an oscillator and transmits pulses also to a counting circuit, such as 110, which performs the same function during non-operation of the motor as was performed during its operation. Since the time of nonoperation of the powering motor 24 is considerably longer than the typical interval required for administration of medication, the pulse-counting circuit will include more than just two pulse counters 114 and 116. But at least the first two counters of an enlarged arrangement thereof can be counters 114, 116 to avoid duplication.
The primary use of the device 10 is, of course, for administering a predetermined volume of medication on a timed schedule. However, it is not strictly limited to this use, but also may be operated by monitoring equipment separate and apart from the timing devices 66 and 74 described herein. In other words, assume a cardiac patient has monitoring equipment to indicate when he is in medical difficulty. Such monitoring equipment could be used to provide a pulse which starts the motor 24 in operation and which causes the injection of the predetermined volume of medication to counteract the condition sensed by the monitoring equipment as requiring said medication.
From the foregoing description, it should be readily appreciated that there has been described herein a unique medication injection device 10 which is capable of administering medication in accordance with a selected schedule of successive intervals of operation and non-operation of the powering motor 24. Moreover, these intervals are controlled as a function of each rotational traverse, rather than strictly on a manually timed basis, as is the practice in the prior art. Thus, the device 10 hereof is not vulnerable to variations which affect performance during any selected unit of time, such as variations in voltage, in viscosity of the medication being dispensed, variations in the frictional resistance within the motor itself, to mention just a few, and other such factors which adversely affect and produce nonuniformity in the functioning of devices of the class herein described.
A latitude of modification, change and substitution is intended in the foregoing disclosure, and in some instances some features of the invention will be employed without a corresponding use of other features. Accordingly, it is appropriate that the appended claims be con trued broadly and in a manner consistent with the spirit and scope of the invention herein.
What is claimed is:
l. A medication injection device comprising a syringe for dispensing medication in accordance with linear displacement of a plunger thereof, means secured to said syringe for connection to a patient for dispensing said medication to said patient, a rotatively mounted lead screw with threads of uniform pitch disposed in substantially parallel relation to the linear displacement path of said syringer plunger, pushing means mounted on said lead screw for advancement therealong in pushing engagement with said syringe plunger, a motor operatively arranged to power said lead screw in rotation to cause advancement of said pushing means and corresponding linear displacement of said syringe plunger, a radially oriented striker mounted on said lead screw, a pulse-emitting switch located adjacent said lead screw in the path of the rotational traverse of said striker so as to be engaged thereby to cause an emission of an electrical pulse during each rotation of said lead screw, and a pulse-counting means electrically connected to receive the transmission of each aforesaid pulse and operatively connected to permit the operation of said motor for the duration of the transmission thereto of a selected number of said ppulses, whereby medication is dispensed in accordance with the linear displacement of said syringe plunger as a function of the number of rotational traverses of said lead screw as counted by said pulsecounting means.
2. A medication injection device as defined in claim 1 including an additional timing means operatively connected to said motor to cause the commencement of the operation thereof after a selected interval of nonoperation, whereby said medication is dispensed by said device in accordance with a selected schedule of successive intervals of operation and non-operation of said motor.
3. A medication injection device as defined in claim 2 including a clutch interposed in the drive connection between said motor and said lead screw, and including means mounting said lead screw for selected limited linear movement for disengaging the same from said clutch to thereby terminate the powering rotation of said lead screw by said motor, whereby said dispensing of medication by said device is capable of being terminated in an emergency situation.
4. A medication injection device as defined in claim 2 wherein said additional timing means is of the type operated by pulses transmitted to it as is also said pulsecounting means, and further including a visual signaling device connected to be operated by each pulse being transmitted to said additional timing means and to said pulse-counting means, whereby the operation of said visual signal device is effective in indicating the working condition of said medication injection device.
5. A medication injection device as defined in claim 4 including a scale calibrating linear displacement of said syringe plunger with an ascending number of pulses produced during said rotational operation of said motor, whereby the volume of medication to be dispensed can be readily related to a selected number of pulses as counted by said pulse-counting means.
|Cited Patent||Filing date||Publication date||Applicant||Title|
|US2602446 *||Feb 27, 1950||Jul 8, 1952||Antonina S Glass||Automatic medical injection apparatus|
|US2627270 *||Feb 9, 1946||Feb 3, 1953||Antonina S Glass||Self-propelled automatic syringe|
|US3091239 *||Aug 25, 1959||May 28, 1963||Wilhelm Moeller||Apparatus for intravasal injection of gaseous and liquid media|
|US3631847 *||Mar 25, 1969||Jan 4, 1972||James C Hobbs||Method and apparatus for injecting fluid into the vascular system|
|US3701345 *||Sep 29, 1970||Oct 31, 1972||Medrad Inc||Angiographic injector equipment|
|Citing Patent||Filing date||Publication date||Applicant||Title|
|US3912127 *||Oct 29, 1974||Oct 14, 1975||Graco Inc||Precision metering system|
|US3985133 *||May 28, 1974||Oct 12, 1976||Imed Corporation||IV pump|
|US4044764 *||Oct 30, 1975||Aug 30, 1977||Szabo Anthony W||Fluid infusion apparatus|
|US4059110 *||Oct 7, 1976||Nov 22, 1977||Timex Corporation||Clockwork driven hypodermic syringe|
|US4140117 *||May 19, 1977||Feb 20, 1979||Alza Corporation||Cartridge for liquid infusion apparatus|
|US4157716 *||Feb 2, 1978||Jun 12, 1979||Contraves Ag||Apparatus for the dosed dispensing of a liquid|
|US4191187 *||Mar 8, 1978||Mar 4, 1980||National Research Development Corporation||Medical apparatus|
|US4196730 *||Aug 1, 1977||Apr 8, 1980||Wilson Dennis R||Liquid drug dispenser|
|US4298575 *||Aug 27, 1979||Nov 3, 1981||Lkb Clinicon Aktiebolag||Pipetting and dosing device|
|US4345483 *||Sep 4, 1980||Aug 24, 1982||Clinicon International Gmbh||Metering apparatus|
|US4601707 *||May 22, 1981||Jul 22, 1986||Albisser Anthony M||Insulin infusion device|
|US4648872 *||Nov 15, 1983||Mar 10, 1987||Kamen Dean L||Volumetric pump with replaceable reservoir assembly|
|US4652260 *||Mar 11, 1985||Mar 24, 1987||Strato Medical Corporation||Infusion device|
|US4731058 *||May 22, 1986||Mar 15, 1988||Pharmacia Deltec, Inc.||Drug delivery system|
|US4767406 *||Oct 10, 1986||Aug 30, 1988||Vickers Plc.||Syringe pumps|
|US4833384 *||Jul 20, 1987||May 23, 1989||Syntex (U.S.A.) Inc.||Syringe drive assembly|
|US4838860 *||Jun 26, 1987||Jun 13, 1989||Pump Controller Corporation||Infusion pump|
|US4898579 *||Jun 3, 1988||Feb 6, 1990||Pump Controller Corporation||Infusion pump|
|US4976696 *||Jun 16, 1989||Dec 11, 1990||Becton, Dickinson And Company||Syringe pump and the like for delivering medication|
|US5101679 *||Jan 8, 1990||Apr 7, 1992||Ivac Corporation||Screw drive engagement/disengagement and decoupling mechanism|
|US5106375 *||May 23, 1991||Apr 21, 1992||Ivac Corporation||Dynamic lead screw engagement and indicator|
|US5147311 *||Aug 29, 1988||Sep 15, 1992||Ewald Pickhard||Injection device for use with a deformable ampoule|
|US5236416 *||May 23, 1991||Aug 17, 1993||Ivac Corporation||Syringe plunger position detection and alarm generation|
|US5244461 *||Mar 12, 1990||Sep 14, 1993||Graseby Medical Limited||Infusion pump with occlusion sensitive shutoff|
|US5269762 *||Apr 21, 1992||Dec 14, 1993||Sterling Winthrop, Inc.||Portable hand-held power assister device|
|US5273537 *||Mar 6, 1992||Dec 28, 1993||Scimed Life Systems, Inc.||Power-assisted inflation apparatus|
|US5322511 *||Nov 19, 1993||Jun 21, 1994||Sterling Winthrop Inc.||Portable hand-held power injector|
|US5347998 *||Jul 8, 1991||Sep 20, 1994||Minnesota Mining And Manufacturing Company||Breath actuated inhaler having an electromechanical priming mechanism|
|US5533981 *||Oct 6, 1994||Jul 9, 1996||Baxter International Inc.||Syringe infusion pump having a syringe plunger sensor|
|US5545140 *||Jul 5, 1994||Aug 13, 1996||Ivac Corporation||Syringe plunger driver|
|US5647853 *||Mar 3, 1995||Jul 15, 1997||Minimed Inc.||Rapid response occlusion detector for a medication infusion pump|
|US5672155 *||Jun 14, 1996||Sep 30, 1997||Riley; Robert Q.||Fluid transfer apparatus|
|US5695464 *||Dec 28, 1994||Dec 9, 1997||Zambon Group Spa||Method of injection controlled by an infusion pump|
|US5792102 *||Jan 25, 1995||Aug 11, 1998||Mallinckrodt Medical, Inc.||Conversion kit for a machine for automatic intravascular injection of solutions|
|US5814015 *||Feb 24, 1995||Sep 29, 1998||Harvard Clinical Technology, Inc.||Infusion pump for at least one syringe|
|US5925018 *||Nov 13, 1995||Jul 20, 1999||Cma/Microdialysis Ab||Infusion and microdialysis pump|
|US5954697 *||Mar 2, 1998||Sep 21, 1999||Srisathapat; Chad||Threaded nut syringe plunger for use with a medication infusion pump|
|US6042565 *||Oct 18, 1996||Mar 28, 2000||Medrad, Inc.||Syringe, injector and injector system|
|US6048334 *||Feb 20, 1998||Apr 11, 2000||Medrad, Inc.||Syringe, injector and injector system|
|US6428509||Jul 29, 1999||Aug 6, 2002||Alaris Medical Systems, Inc.||Syringe plunger driver system and method|
|US6482186||Sep 29, 2000||Nov 19, 2002||Sterling Medivations, Inc.||Reusable medication delivery device|
|US6575936 *||Sep 27, 2000||Jun 10, 2003||Japan Servo Co., Ltd.||Liquid infusion apparatus|
|US7238164||Dec 31, 2002||Jul 3, 2007||Baxter International Inc.||Systems, methods and apparatuses for pumping cassette-based therapies|
|US7494480 *||Apr 17, 2003||Feb 24, 2009||Disetronic Licensing Ag||Device for administering an injectable product in doses|
|US7543516 *||Jul 22, 2005||Jun 9, 2009||Cardinal Health 303, Inc.||Dynamic lead screw thread engagement system and method|
|US7658196||Apr 25, 2007||Feb 9, 2010||Ethicon Endo-Surgery, Inc.||System and method for determining implanted device orientation|
|US7731689||Feb 15, 2007||Jun 8, 2010||Baxter International Inc.||Dialysis system having inductive heating|
|US7744554||Jun 28, 2007||Jun 29, 2010||Baxter International Inc.||Cassette alignment and integrity testing for dialysis systems|
|US7775215||Mar 7, 2006||Aug 17, 2010||Ethicon Endo-Surgery, Inc.||System and method for determining implanted device positioning and obtaining pressure data|
|US7775966||Mar 7, 2006||Aug 17, 2010||Ethicon Endo-Surgery, Inc.||Non-invasive pressure measurement in a fluid adjustable restrictive device|
|US7815603||Aug 1, 2007||Oct 19, 2010||Alcon Research, Ltd.||Ophthalmic injection method|
|US7844342||Feb 7, 2008||Nov 30, 2010||Ethicon Endo-Surgery, Inc.||Powering implantable restriction systems using light|
|US7871399||Aug 1, 2007||Jan 18, 2011||Alcon Research, Ltd.||Disposable ophthalmic injection device|
|US7887521||Aug 1, 2007||Feb 15, 2011||Alcon Research, Ltd.||Ophthalmic injection system|
|US7927270||Jan 29, 2007||Apr 19, 2011||Ethicon Endo-Surgery, Inc.||External mechanical pressure sensor for gastric band pressure measurements|
|US7998115||Feb 15, 2007||Aug 16, 2011||Baxter International Inc.||Dialysis system having optical flowrate detection|
|US8016744||Mar 7, 2006||Sep 13, 2011||Ethicon Endo-Surgery, Inc.||External pressure-based gastric band adjustment system and method|
|US8016745||Apr 6, 2006||Sep 13, 2011||Ethicon Endo-Surgery, Inc.||Monitoring of a food intake restriction device|
|US8034065||Feb 26, 2008||Oct 11, 2011||Ethicon Endo-Surgery, Inc.||Controlling pressure in adjustable restriction devices|
|US8057492||Feb 12, 2008||Nov 15, 2011||Ethicon Endo-Surgery, Inc.||Automatically adjusting band system with MEMS pump|
|US8066629||Feb 12, 2007||Nov 29, 2011||Ethicon Endo-Surgery, Inc.||Apparatus for adjustment and sensing of gastric band pressure|
|US8100870||Dec 14, 2007||Jan 24, 2012||Ethicon Endo-Surgery, Inc.||Adjustable height gastric restriction devices and methods|
|US8114345||Feb 8, 2008||Feb 14, 2012||Ethicon Endo-Surgery, Inc.||System and method of sterilizing an implantable medical device|
|US8118790||Oct 9, 2007||Feb 21, 2012||Alcon Research, Ltd.||Battery operated surgical hand piece with disposable end|
|US8142452||Dec 27, 2007||Mar 27, 2012||Ethicon Endo-Surgery, Inc.||Controlling pressure in adjustable restriction devices|
|US8152710||Feb 28, 2008||Apr 10, 2012||Ethicon Endo-Surgery, Inc.||Physiological parameter analysis for an implantable restriction device and a data logger|
|US8177747||Nov 30, 2010||May 15, 2012||Alcon Research, Ltd.||Method and apparatus for drug delivery|
|US8187162||Mar 6, 2008||May 29, 2012||Ethicon Endo-Surgery, Inc.||Reorientation port|
|US8187163||Dec 10, 2007||May 29, 2012||Ethicon Endo-Surgery, Inc.||Methods for implanting a gastric restriction device|
|US8192350||Jan 28, 2008||Jun 5, 2012||Ethicon Endo-Surgery, Inc.||Methods and devices for measuring impedance in a gastric restriction system|
|US8206338||Jul 3, 2007||Jun 26, 2012||Baxter International Inc.||Pumping systems for cassette-based dialysis|
|US8221439||Feb 7, 2008||Jul 17, 2012||Ethicon Endo-Surgery, Inc.||Powering implantable restriction systems using kinetic motion|
|US8233995||Mar 6, 2008||Jul 31, 2012||Ethicon Endo-Surgery, Inc.||System and method of aligning an implantable antenna|
|US8323231||Dec 28, 2006||Dec 4, 2012||Baxter International, Inc.||Method and apparatus for monitoring and controlling peritoneal dialysis therapy|
|US8337389||Jan 28, 2008||Dec 25, 2012||Ethicon Endo-Surgery, Inc.||Methods and devices for diagnosing performance of a gastric restriction system|
|US8361023||Feb 15, 2007||Jan 29, 2013||Baxter International Inc.||Dialysis system with efficient battery back-up|
|US8372036||May 5, 2010||Feb 12, 2013||Alcon Research, Ltd.||Multi-layer heat assembly for a drug delivery device|
|US8377079||Dec 27, 2007||Feb 19, 2013||Ethicon Endo-Surgery, Inc.||Constant force mechanisms for regulating restriction devices|
|US8523827||Dec 10, 2002||Sep 3, 2013||Dca Design International Limited||Medicament injection apparatus|
|US8545435||Mar 11, 2005||Oct 1, 2013||Baxter International, Inc.||Method and apparatus for providing medical treatment therapy based on calculated demand|
|US8558964||Feb 15, 2007||Oct 15, 2013||Baxter International Inc.||Dialysis system having display with electromagnetic compliance (“EMC”) seal|
|US8591395||Jan 28, 2008||Nov 26, 2013||Ethicon Endo-Surgery, Inc.||Gastric restriction device data handling devices and methods|
|US8591532||Feb 12, 2008||Nov 26, 2013||Ethicon Endo-Sugery, Inc.||Automatically adjusting band system|
|US8617127||Dec 10, 2002||Dec 31, 2013||Dca Design International Limited||Medicament injection apparatus|
|US8632511||May 5, 2010||Jan 21, 2014||Alcon Research, Ltd.||Multiple thermal sensors in a multiple processor environment for temperature control in a drug delivery device|
|US8870742||Feb 28, 2008||Oct 28, 2014||Ethicon Endo-Surgery, Inc.||GUI for an implantable restriction device and a data logger|
|US8870812||Feb 15, 2007||Oct 28, 2014||Baxter International Inc.||Dialysis system having video display with ambient light adjustment|
|US8876793 *||Dec 21, 2010||Nov 4, 2014||Smiths Medical Asd, Inc.||Flushing a fluid line from a medical pump|
|US8926553||Dec 21, 2001||Jan 6, 2015||Christopher Nigel Langley||Pen-type injector having an electronic control unit|
|US9022970||Oct 9, 2007||May 5, 2015||Alcon Research, Ltd.||Ophthalmic injection device including dosage control device|
|US9138534||May 11, 2008||Sep 22, 2015||Roche Diabetes Care, Inc.||Positive displacement pump|
|US9474842||Nov 26, 2012||Oct 25, 2016||Baxter International Inc.||Method and apparatus for monitoring and controlling peritoneal dialysis therapy|
|US20030114801 *||Dec 10, 2002||Jun 19, 2003||Dca Design International Limited||Medicament injection apparatus|
|US20040006310 *||Apr 17, 2003||Jan 8, 2004||Simone Geiser||Device for administering an injectable product in doses|
|US20040019313 *||Dec 31, 2002||Jan 29, 2004||Childers Robert W.||Systems, methods and apparatuses for pumping cassette-based therapies|
|US20040054318 *||Dec 21, 2001||Mar 18, 2004||Langley Christopher Nigel||Pen-type injector having an electronic control unit|
|US20040054328 *||Dec 21, 2001||Mar 18, 2004||Langley Christopher Nigel||Pen-type injector having an electronic control unit|
|US20050182355 *||Mar 11, 2005||Aug 18, 2005||Tuan Bui||Method and apparatus for providing medical treatment therapy based on calculated demand|
|US20050209563 *||Mar 16, 2005||Sep 22, 2005||Peter Hopping||Cassette-based dialysis medical fluid therapy systems, apparatuses and methods|
|US20060211912 *||Mar 7, 2006||Sep 21, 2006||Dlugos Daniel F||External pressure-based gastric band adjustment system and method|
|US20070060887 *||Jul 14, 2006||Mar 15, 2007||Marsh David A||Ophthalmic injector|
|US20070074596 *||Jul 22, 2005||Apr 5, 2007||Cardinal Health 303, Inc.||Dynamic lead screw thread engagement system and method|
|US20070135758 *||Dec 28, 2006||Jun 14, 2007||Baxter International Inc.||Method and apparatus for monitoring and controlling peritoneal dialysis therapy|
|US20070270744 *||Aug 1, 2007||Nov 22, 2007||Bruno Dacquay||Limited Reuse Assembly For Ophthalmic Injection Device|
|US20070270750 *||May 17, 2006||Nov 22, 2007||Alcon, Inc.||Drug delivery device|
|US20070293820 *||Aug 1, 2007||Dec 20, 2007||Bruno Dacquay||Disposable Ophthalmic Injection Device|
|US20080015406 *||Jan 29, 2007||Jan 17, 2008||Dlugos Daniel F||External Mechanical Pressure Sensor for Gastric Band Pressure Measurements|
|US20080021438 *||Aug 1, 2007||Jan 24, 2008||Bruno Dacquay||Ophthalmic Injection Method|
|US20080103429 *||Jul 2, 2007||May 1, 2008||Baxter International Inc.||Pumping material for cassette based dialysis and pumping mechanism using same|
|US20080132828 *||Jun 28, 2007||Jun 5, 2008||Baxter International Inc.||Cassette alignment and integrity testing for dialysis systems|
|US20080200865 *||Feb 15, 2007||Aug 21, 2008||Baxter International Inc.||Dialysis system having optical flowrate detection|
|US20080200868 *||Feb 15, 2007||Aug 21, 2008||One Baxter Parkway||Dialysis system having video display with ambient light adjustment|
|US20080200869 *||Feb 15, 2007||Aug 21, 2008||Baxter International Inc.||Dialysis system with efficient battery back-up|
|US20080249806 *||Feb 28, 2008||Oct 9, 2008||Ethicon Endo-Surgery, Inc||Data Analysis for an Implantable Restriction Device and a Data Logger|
|US20080250340 *||Feb 28, 2008||Oct 9, 2008||Ethicon Endo-Surgery, Inc.||GUI for an Implantable Restriction Device and a Data Logger|
|US20080250341 *||Feb 28, 2008||Oct 9, 2008||Ethicon Endo-Surgery, Inc.||Gui With Trend Analysis for an Implantable Restriction Device and a Data Logger|
|US20080281292 *||Jul 23, 2007||Nov 13, 2008||Hickingbotham Dyson W||Retractable Injection Port|
|US20090036846 *||Aug 1, 2007||Feb 5, 2009||Bruno Dacquay||Ophthalmic Injection System|
|US20090093788 *||Oct 1, 2008||Apr 9, 2009||Alcon Research, Ltd.||Thermal Coefficient Driven Drug Pellet Size For Ophthalmic Injection|
|US20090093789 *||Oct 1, 2008||Apr 9, 2009||Alcon Research, Ltd.||Method of Delivering A Rate And Temperature - Dependent Substance Into The Eye|
|US20090149874 *||Dec 10, 2007||Jun 11, 2009||Ethicon Endo-Surgery. Inc.||Methods for implanting a gastric restriction device|
|US20090171375 *||Dec 27, 2007||Jul 2, 2009||Ethicon Endo-Surgery, Inc.||Controlling pressure in adjustable restriction devices|
|US20090171379 *||Dec 27, 2007||Jul 2, 2009||Ethicon Endo-Surgery, Inc.||Fluid logic for regulating restriction devices|
|US20090202387 *||Feb 8, 2008||Aug 13, 2009||Ethicon Endo-Surgery, Inc.||System and method of sterilizing an implantable medical device|
|US20090204131 *||Feb 12, 2008||Aug 13, 2009||Ethicon Endo-Surgery, Inc.||Automatically adjusting band system with mems pump|
|US20090204141 *||Feb 7, 2008||Aug 13, 2009||Ethicon Endo-Surgery, Inc.||Powering implantable restriction systems using kinetic motion|
|US20090204179 *||Feb 7, 2008||Aug 13, 2009||Ethicon Endo-Surgery, Inc.||Powering implantable restriction systems using temperature|
|US20090216255 *||Feb 26, 2008||Aug 27, 2009||Ethicon Endo-Surgery, Inc.||Controlling pressure in adjustable restriction devices|
|US20090222065 *||Feb 28, 2008||Sep 3, 2009||Ethicon Endo-Surgery, Inc.||Physiological Parameter Analysis for an Implantable Restriction Device and a Data Logger|
|US20090228028 *||Mar 6, 2008||Sep 10, 2009||Ethicon Endo-Surgery, Inc.||Reorientation port|
|US20090228063 *||Mar 6, 2008||Sep 10, 2009||Ethicon Endo-Surgery, Inc.||System and method of communicating with an implantable antenna|
|US20090259180 *||Apr 11, 2008||Oct 15, 2009||Jong Soo Choi||Injection method using injector with length-adjustable needle and injection apparatus using the same|
|US20090287150 *||Oct 4, 2007||Nov 19, 2009||Bruno Dacquay||Universal Rechargeable Limited Reuse Assembly For Ophthalmic Hand Piece|
|US20100030136 *||Oct 9, 2007||Feb 4, 2010||Bruno Dacquay||Ophthalmic Injection Device Including Dosage Control Device|
|US20100106083 *||Oct 3, 2007||Apr 29, 2010||Alcon Research, Ltd.||Method of Operating Ophthalmic Hand Piece with Disposable End|
|US20100106089 *||Oct 1, 2007||Apr 29, 2010||Cesario Dos Santos||Temperature control device and thermal sensor assembly for medical device|
|US20100130932 *||May 11, 2008||May 27, 2010||Ofer Yodfat||Positive displacement pump|
|US20100211044 *||Oct 9, 2007||Aug 19, 2010||Alcon Manufacturing, Lted.||Battery operated surgical hand piece with disposable end|
|US20100286632 *||May 5, 2010||Nov 11, 2010||Cesario Pereira Dos Santos||Multi-Layer Heat Assembly For A Drug Delivery Device|
|US20100286654 *||May 5, 2010||Nov 11, 2010||Cesario Pereira Dos Santos||Multiple Thermal Sensors in a Multiple Processor Environment for Temperature Control in a Drug Delivery Device|
|US20110152767 *||Nov 30, 2010||Jun 23, 2011||Pinedjian Raffi S||Method and Apparatus for Drug Delivery|
|US20110218487 *||May 18, 2011||Sep 8, 2011||Baxter International Inc.||Pumping material for cassette based dialysis and pumping mechanism using same|
|US20120083760 *||Dec 21, 2010||Apr 5, 2012||Smiths Medical Asd, Inc.||Flushing a Fluid Line From a Medical Pump|
|USRE35979 *||Dec 10, 1991||Dec 1, 1998||Mtfp, Inc.||Angiographic injector and angiographic syringe for use therewith|
|EP0009013A1 *||Aug 29, 1979||Mar 19, 1980||Lkb Clinicon Aktiebolag||A pipetting and dosing device|
|EP0123836A2 *||Mar 9, 1984||Nov 7, 1984||B. Braun-SSC AG||Method of delivering an early alarm signal to a syringe pump|
|EP0123836A3 *||Mar 9, 1984||May 22, 1985||Intermedicat Gmbh||Method of delivering an early alarm signal to a syringe pump|
|EP0140622A1 *||Oct 12, 1984||May 8, 1985||Corning Glass Works||Friction drive for fluid metering system|
|EP0204977A1 *||May 12, 1986||Dec 17, 1986||Ivion Corporation||Syringe drive apparatus|
|EP0265536A1 *||Oct 27, 1986||May 4, 1988||Elda Marinoni||Device for dilating the neck of the uterus for medical use|
|EP0388102A2 *||Mar 9, 1990||Sep 19, 1990||The BOC Group plc||Improvements in infusion pumps|
|EP0398394A2 *||Nov 8, 1984||Nov 22, 1990||KAMEN, Dean L.||Reservoir assembly for removable engagement with a motor drive|
|EP0398394A3 *||Nov 8, 1984||Dec 27, 1990||Dean L. Kamen||Reservoir assembly for removable engagement with a motor drive|
|EP0567945A1 *||Apr 23, 1993||Nov 3, 1993||Becton Dickinson and Company||Syringe pump with biased lockable syringe clamp|
|EP0567962A1 *||Apr 26, 1993||Nov 3, 1993||Becton Dickinson and Company||Syringe pump control system|
|WO1982001998A1 *||Dec 9, 1981||Jun 24, 1982||Corp Ivac||Mechanism for screw drive and syringe plunger engagement/disengagement|
|WO1986001117A1 *||Aug 1, 1985||Feb 27, 1986||Fresenius Ag||Spray pump|
|WO1987007843A1 *||Jun 17, 1987||Dec 30, 1987||Bernard Hazon||Monostroke syringe pusher for automatic parenteral injections with servo-control and programming|
|WO1989011883A1 *||Jun 6, 1989||Dec 14, 1989||Dell Orti Massimo||Automatic aspiration and/or injection device for medical purposes|
|WO1990010468A1 *||Mar 12, 1990||Sep 20, 1990||Graseby Medical Limited||Infusion pump|
|WO1994014487A1 *||Dec 20, 1993||Jul 7, 1994||John Elvin Teasdale||Improved pulsed infusion system|
|WO1995020410A1 *||Jan 25, 1995||Aug 3, 1995||Mallinckrodt Medical, Inc.||A conversion kit for a machine for automatic intravascular injection of solutions|
|WO2002051476A1 *||Dec 21, 2001||Jul 4, 2002||Dca Design International Limited||Pen-type injector having an electronic control unit|
|WO2008106805A1 *||Mar 2, 2007||Sep 12, 2008||Tecpharma Licensing Ag||Administration appliance with occlusion identification|
|U.S. Classification||604/155, 128/DIG.100|
|Cooperative Classification||A61M5/1456, Y10S128/01|
|Jan 28, 1983||AS02||Assignment of assignor's interest|
Owner name: AUTO SYRINGE, INC.
Effective date: 19820927
Owner name: BAXTER TRAVENOL LABORATORIES, INC., ONE BAXTER PAR
|Jan 28, 1983||AS||Assignment|
Owner name: BAXTER TRAVENOL LABORATORIES, INC., ONE BAXTER PAR
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST.;ASSIGNOR:AUTO SYRINGE, INC.;REEL/FRAME:004088/0422
Effective date: 19820927