|Publication number||US3861380 A|
|Publication date||Jan 21, 1975|
|Filing date||Oct 24, 1972|
|Priority date||Feb 28, 1969|
|Also published as||DE2009356A1, DE2009356B2|
|Publication number||US 3861380 A, US 3861380A, US-A-3861380, US3861380 A, US3861380A|
|Inventors||Chassagne Daniel, Delouche Gilles, Fradin Jean, Rocoplan Jean-Antoine|
|Original Assignee||Commissariat Energie Atomique|
|Export Citation||BiBTeX, EndNote, RefMan|
|Patent Citations (8), Referenced by (64), Classifications (13), Legal Events (2)|
|External Links: USPTO, USPTO Assignment, Espacenet|
United States Patent [191 Chassagne et al.
[ 1 Jan. 21, 1975 I RADIOACTIVE SOURCE PROJECTOR  Inventors: Daniel Chassagne, Wissous; Gilles Delouche, Paris; Jean Fradin, Bois Comombes; Jean-Antoine Rocoplan, Sevres, all of France  Assignee: Commissariat a LEnergie Atomique, Paris, France  Filed: Oct. 24, 1972 21 Appl. No.: 300,222
Related U.S. Application Data  Continuation-impart of Ser. No. 11,226, Feb. 13,
 Foreign Application Priority Data Feb. 28, 1969 France 6905574  US. Cl. l28/1.2, 250/497  Int. Cl A6ln 5/01  Field of Search 128/1.1, 1.2; 250/363, 250/366, 369, 327, 303, 393, 497507  References Cited UNITED STATES PATENTS 2,750,517 6/1956 Baum 128/1.2 X 2,798,164 7/1957 Untermeyer .1 2,862,108 11/1958 Meilink 128/12 UX 2,916,628 Prest 250/ 106 12/1959 3,147,383 9/1964 Prest 250/106 X 3,224,432 12/1965 Billingsley... 128/12 3,323,511 6/1967 Holter 128/12 3,669,093 6/1972 Sauerwein et al. 128/11 FOREIGN PATENTS OR APPLICATIONS 1,095,963 12/1960 Germany 128/11 479,311 11/1969 Switzerland 128/12 OTHER PUBLICATIONS Intern. Abstracts of Surgery, Vol. 96, No. 6, June, 1953, p. 595.
Primary Examinerl(yle L. Howell Attorney, Agent, or Firm-Craig & Antonelli  ABSTRACT A radioactive source projector for the treatment of cancerous lesions, said projector comprising, on the one hand, a projector unit containing a shield block and, on the other hand, ancillary means for displacing radioactive sources, said means being constituted by source-holders formed by a flexible metallic spring and each of which is intended to be applied at one end in the vicinity of the lesions, and to be joined to an actuating cable, each source holder being contained in a flexible tube secured to a flexible ejection sheath.
13 Claims, 5 Drawing Figures Pmmeu M21 1975 SHEU 1 UF 3 PATENTEU JAN 21 I875 FIGS RADIOACTIVE SOURCE PROJECTOR CROSS REFERENCE TO RELATED APPLICATION:
This application is a continuation-impart of applicants co-pending application Ser. No. 1 1,226 filed on Feb. 13, 1970, now abandoned.
The present invention relates to a radioactive source projector which is intended to be employed in plesiocurietherapy according to the method known as nonradioactive preparation for the treatment of cancerous lesions at the surface of the human body or in either artificial or natural cavities (endocurietherapy), in particular in gynecology.
It is known that, in gynecology, there are essentially two types of methods for the treatment of cancerous lesions, namely transcutaneous teleradiotherapy, whether associated with surgical methods or not, and plesiocurietherapy which has the object of sterilizing the cancerous tumor at the level of the uterine cervix and of its immediately adjacent extensions.
This second method makes use of radioactive sources which are inserted into the vagina and the uterus and which are maintained in contact with the cancerous lesions.
The majority of methods for the treatment of lesions of this type by plesiocurietherapy require the introduction of a probe in the uterus and of a colpostat in the vagina.
In the oldest methods of treatment, these two devices which are known as applicators are loaded with radioactive sources before being brought into the operating room and placed in position on the patient, and it is often difficult to protect personnel against the radioactivity of the sources all the more as the treatment which is carried out calls for the use of sources having higher activity and that a greater number of persons may come close to the patient while the sources are being placed in position and throughout the period of application.
During the last few years, plesiocurietherapy has made substantial strides in the field of radiation protection by virtue of the application of the so-called nonradioactive preparation technique which consists in dissociating the positioning of applicators (colpostat and probe) from the positioning of radioactive sources in these applicators.
In other words, the applicators are first placed in position and it is only during a second stage that the radio active sources are inserted in the applicators by means of outer tubes.
The present invention relates to a plesiocurietherapy apparatus or applicator which serves to apply the non radioactive preparation technique. In particular, this apparatus permits accurate remote handling of radioactive sources under conditions of absolute safety; tubes in which the radioactive sources travel are light in weight, flexible, sterilizable, disposable after use and readily disconnectable after the sources have been employed on the patient.
More precisely, the present invention relates to a polyvalent radioactive source projector for plesiocurietherapy according to the method of non-radioactive preparation for the treatment of cancerous lesions at the surface of the body or in either artificial or natural cavities (endocurietherapy) and in particular in gynecology. On the one hand, said projector essentially comprises a projector proper as constituted by a body adapted to rest on a wheeled trolley frame and to contain a shield block which affords protection against radioactive sources and which is formed of a metal or sandwich of heavy metals having a density and an atomic number at least equal to those of lead as well as an electro-mechanical device for transferring said sources which is provided externally with a control panel attached to said body. On the other hand, said projector essentially comprises ancillary means for displacing the sources, said ancillary means being constituted by at least four source-holders each formed of a flexible metallic spring which has contiguous turns fastened together if necessary and which is closed at one end, each source-holder being intended to be applied at one end in the vicinity of or within a cancerous tissue to be treated and being joined by means of a rapid coupling device to an actuating cable which is in turn displaced by said electromechanical transfer device and, in the case of each source-holder, a flexible outer tube which contains said source-holder and permits substantial degrees of curvature is secured by means of a screw-coupling to a flexible ejection sheath which can be joined to the projector proper; and an ancillary unit or control means operatively associated with the electromechanical transfer device for the electric and remote control of displacemnts carried out by the sourceholders from said shield block to their irradiation positions at the ends of the outer tubes and conversely for return from said outer tubes to said shield block.
Further properties and advantages of the present invention will be brought out by the following description in which one embodiment'of the device according to the invention is given by way of explanation but not in any sense by way of limitation.
Reference is made to the accompanying drawings, in which:
FIG. 1 shows in perspective the complete projector unit together with four flexible sheaths, one of which is completed by the corresponding assembly of sourcedisplacement ancillaries;
FIG. 2 is an axial longitudinal sectional view showing a complete set of source-actuating ancillaries;
FIG. 3 is a view in perspective showing the projector unit, a portion of which has been broken away in order to show the block which serves as a shield for the sources and the electromechanical device for transferring said sources;
FIG. 4 illustrates the control panel of said projector unit;
FIG. 5 is a diagram which shows the mode of utilization of the apparatus according to the invention.
The projector unit is constituted by an outer casing or body 14 which rests on a trolley frame 1 having four wheels and contains an electromechanical transfer device 15 (See FIG. 3), devices for stopping sources in the irradiation position or storage position, and a source shield block 16 which dispenses with the need for any permanent shielding means located outside the projector unit. This shield block is formed, for example, of tungsten and lead or of depleted uranium.
A control panel 2 which is rigidly fixed to the projector body comprises control knobs and visual indicators which are intended to carry out, respectively, the general switching-on (reference 17),checking the application of power (reference 18), checking the selection of sources (reference 19), indicating the positions of each source-holder (reference 20) as well as reading irradiation times (reference 21); an access 22 is also provided for the insertion of a resetting key.
Since the projector is shown in FIG. 1 as comprising four source-holders, four flexible sheaths 3 can therefore pass through the side wall 4. Four flaps 5 are pivotally displaceable by means of a key so that, when the apparatus is not in use, the openings 6 formed in the projector body 14 for the penetration of the sheathed cables may accordingly be closed and any displacement of the corresponding source-holders outside the shield block 16 is thereby prevented.
The projector unit also has four openings (not shown in the drawings) which permit the insertion of a crankhandle for the manual return of each source-holder. In addition, a mechanical counter (not shown) which permits the totalization of the number of ejections is located within the projector body 14.
The ancillaries for the displacement of radioactive sources comprise in the case of each of the four sheaths 3:
1. A flexible source-holder 7 which can be of very small size (for example having an external diameter of 2 mm) which permits of its insertion in the uterus without preliminary anesthesia; the length of said source-holder is constant. There is housed within said source-holder 7 a train of radioactive sources 8 obtained by juxtaposition of unit sources such as, for example, sources of cesium-l 37 having a diameter of 1.5 mm and a total permissible activity of 650 mc.
An abutment member 23 has the intended function of preventing the source-holder 7 from passing beyond its correct irradiation position at the front end. This is effected by contact between member 23 and end 12 of outer tube 12. The source-holder 7 may be provided if necessary with identical non-radioactive metallic balls 9.
2. An actuating cable 10 which is connected to the source-holder 7 by means of a rapid coupling device ll and carries out the displacement of the source-holder 7 by means of the electromechanical transfer device which is housed within the projector unit. (The cable is stored in the lower portion of the projector body, for example, on a reel or in the form of a coil.)
3. A flexible outer tube 12 which permits substantial degrees of curvature (for example a radius of curvature of 15 mm). This tube may be formed of a material such as nylon and may have, for example, an external diameter of 5 mm and a length of 30 cm.
4. A flexible sheath 3 which is connected to said outer tube 12 by means of a screw-coupling l3 and has a length of 2 meters.
Finally, the electric remote-control means 15 comprises, for example, a light signal system with one color corresponding to each position of storage, irradiation and transfer of radioactive sources from the shield block 16 (located within the interior of the projector proper) to the end of the outer tubes 12 and conversely.
The mode of utilization of the projector in accordance with the invention is as follows:
1. Opening of one, two or more lateral flaps 5 (carried out by the doctor by means of a control-panel key of which he is the sole possessor) results in final selection of the channels which will be utilized.
2. The projector unit is wheeled to the storage room 24 and dummy source-holders (such as nonradioactive balls, for example) are coupled to the actuating cable 10 3. Said projector unit is then wheeled to the radiographic inspection room 25 in order to check the correct operation of the apparatus before proceeding to irradiation of the patient. The operations involved are identical with those which are subsequently to be carried out for the positioning of radioactive source-holders in the patient and are as fol lows: when the outer tube 12 has been inserted into the vagina the extremity of said outer tube is secured to the sheath 3 by means of the screwcoupling 13. By use of the remote Operation control means 15', the electromechanical transfer device 15 is then actuated and causes the sourceholder 7 (which contains neutral or nonradioactive sources) to pass first out of the projector unit under the thrust exerted by the cable 10 and then into the sheath 3, then into the outer tube 12. It will be appreciated that the sheath 3 has been previously extended from storage in the bottom of the projector unit via rollers 30 which direct the sheath 3 into tube 31 and then out of the casing 14 via the opening covered by flap 5. The sourceholder 7 containing neutral sources is returned into the projector unit, again by means of the remote operation and control device and the outer tube 12, which remains in the vagina, is released from the sheath 3 by means of the screw-coupling l3.
4. The projector unit is returned to the storage room 24 and loaded with radioactive sources (i.e., the source-holder containing the neutral sources is disconnected from cable 13 and replaced by a new source-holder containing radioactive sources).
5. The projector unit is then wheeled to the treatment room 26'to which the patient has been brought after radiographic examination.
6. The sheath 3, which has been extended out of the casing 14, is again attached to the outer tube 12 which has remained in the patient and the same op- 'erations as those performed at the time of radiographic inspection in the room 25 are again carried out.
It should be noted that the projector in accordance with the invention can be put to a number of uses outside the field of gynecology and that radioactive sources other than cesium-l 37 can be employed. This projector permits very different periods of treatments ranging, for example, from one-quarter of an hour to eight days. A further advantage is that the projector can be adapted to the majority of applicators at present in existence (for example probes and colpostats).
An important feature of the apparatus lies in the fact that the control panel 2 can operate only by means of a key which serves both to swing open the lateral flaps 5 and to switch-on the apparatus as a whole.
The projector according to the invention is so designed as to have a small overall size, with the result that it can readily be employed in very small rooms, as well as a light weight (less than kgs), so that the apparatus can readily be moved by one person.
Moreover, the projector has a low exposure rate at the outer surface of its body 14, with the result that it does not require to be completed by any shielding for the purpose of maintaining the exposure rate at legally and medically permissible values.
All the control circuits of the electromechanical devices are supplied with direct current at low voltage (for example 24 V) in order to remove any danger of accidental electrocution.
On the general control panel 2, the reference numeral 27 designates circuit breakers which are intended to initiate shut-down of the apparatus in the event of accidental overvoltage and the reference numeral 28 designates the control knobs of each visual signal circuit.
Reference numeral 30 refers to a pair of rollers for directing sheath 3 through tube 31.
While the novel principles of the invention have been described, it will be understood that various omissions, modifications and changes in these principles may be made by one skilled in the art without departing from the spirit and scope of the invention.
What is claimed is:
l. A radioactive-source projector which comprises:
1. a moveable casing including openings;
2. source-holder means in said casing and extendable through said openings, said source-holder means containing radioactive sources, and said sourceholder means including a flexible tubular element that is closed at one end and adapted to be applied to the vicinity of a cancerous tissue to be treated in a living body, and that is opened at the other end for receiving said radioactive sources;
3. shield block means in said casing containing said source-holder means to afford protection against the radioactive sources positioned within said moveable casing;
4. flexible outer tube means receiving said one end of said source-holder means, said outer tube means having a small outer diameter and being adapted to be placed adjacent to the surface of a living body for treatment of cancerous tissue;
5. flexible ejection sheath means having one end connected to said shield block means and another end connected removably to said flexible outer tube for guiding said source-holder means from said shield block means to said flexible outer tube means;
6. actuating cable means removably coupled to said source-holder means for displacing said sourceholder means through said flexible ejection sheath means; and
7. transfer means for transferring said actuating cable means and the associated source-holder means via said flexible ejection sheath means from said shield block means to said outer tube means and from said outer tube means to said shield block means.
2. The projector according to claim 1, further comprising another source-holder means in said casing containing dummy non-radioactive sources adapted to be connected to said actuating cable and to be used in place of said source-holder means containing radioactive sources.
3. The projector according to claim 1, wherein a plurality of said source-holder means containing radioactive sources are provided with an equal plurality of associated flexible outer tube means, actuating cable means, flexible ejection sheath means and transfer means, each of said associated means being associated, respectively, with each of said source-holder means and with said shield block means whereby a plurality of said cancerous tissues can be treated with said projector.
4. The projector according to claim 1, wherein said transfer means is an electromechanical transfer device which is electrically controlled to effect displacement of said actuating cable means and its associated sourceholder means.
5. The projector according to claim 1, wherein said source-holder means is connected to said actuating cable means by a rapid coupling means.
6. The projector according to claim 1, wherein said flexible outer tube means is connected to said flexible ejection sheath means by a screw coupling.
7. The projector according to claim 1, wherein said source-holder means is a thin elongated metallic element having an external diameter on the order of 2 8. The projector according to claim 1, wherein the radioactive sources contained in said source-holder means are cesium-137 sources.
9. The projector according to claim 1, wherein a train of sources is housed in said source-holder means said train being formed by a plurality of unit sources having a diameter of 1.5 mm to provide a total activity of 650 10. The projector according to claim 1, wherein said outer flexible tube means has an external diameter on the order of 5 mm and a length on the order of 30 cm.
11. The projector according to claim 1, wherein said shield block means is formed of tungsten and lead.
12. The projector according to claim 1, wherein said shield block means is formed of depleted uranium.
13. The projector according to claim 1, wherein said source-holder means includes an abutment member which contacts an open end of said flexible outer tube means to prevent the source-holder means from passing beyond a correct irradiation position at the front of said open end of said flexible outer tube means.
|Cited Patent||Filing date||Publication date||Applicant||Title|
|US2750517 *||Dec 21, 1953||Jun 12, 1956||Baum Wilhelm M||Method of handling radio-active materials|
|US2798164 *||Apr 20, 1954||Jul 2, 1957||Samuel Untermyer||Portable chi-ray or gamma source|
|US2862108 *||Jun 18, 1953||Nov 25, 1958||Asea Ab||Device for containing and exposing a radioactive material|
|US2916628 *||Mar 16, 1955||Dec 8, 1959||Technical Operations Inc||Radiographic device|
|US3147383 *||May 16, 1962||Sep 1, 1964||Technical Operations Inc||Apparatus for manipulating radioactive material to and from a storage chamber|
|US3224432 *||Apr 10, 1963||Dec 21, 1965||Billingsley Frank S||Device for irradiating a body cavity|
|US3323511 *||Mar 5, 1962||Jun 6, 1967||Holter Company||Radiation source applicator|
|US3669093 *||Dec 30, 1969||Jun 13, 1972||Goedecke Hans||Apparatus for giving medical treatment by irradiation from radioactive substances|
|Citing Patent||Filing date||Publication date||Applicant||Title|
|US4631415 *||Sep 25, 1984||Dec 23, 1986||Kurt Sauerwein||Radiation treatment apparatus|
|US4851694 *||Jan 27, 1988||Jul 25, 1989||Campaignie ORIS Industrie||Device for driving and positioning a source holder in an applicator used in radiotherapy|
|US4881937 *||Jul 10, 1987||Nov 21, 1989||Eric van't Hooft||Method of treating a part of the body with radioactive material and a trolley for use therein|
|US4881938 *||Feb 18, 1987||Nov 21, 1989||Hooft Eric T Van||Method and an apparatus for treating a part of the body with radioactive material|
|US4897076 *||Nov 25, 1985||Jan 30, 1990||Puthawala Ajmel A||Detachable and remote controllable afterloading device for radiation|
|US5092834 *||Oct 12, 1990||Mar 3, 1992||Omnitron International, Inc.||Apparatus and method for the remote handling of highly radioactive sources in the treatment of cancer|
|US5103395 *||Aug 20, 1990||Apr 7, 1992||Spako David W||System for remote positioning of a radioactive source into a patient including means for protection against improper patient exposure to radiation|
|US5554160 *||May 23, 1995||Sep 10, 1996||Caillouette; James C.||Uterus maneuvering method|
|US5556401 *||Jul 20, 1995||Sep 17, 1996||Caillouette; James C.||Uterus maneuvering and associated apparatus and method, with controlled drive|
|US5653683 *||Feb 28, 1995||Aug 5, 1997||D'andrea; Mark A.||Intracavitary catheter for use in therapeutic radiation procedures|
|US5720717 *||Jan 24, 1997||Feb 24, 1998||D'andrea; Mark A.||Intracavitary catheter for use in therapeutic radiation procedures|
|US5800333 *||Feb 20, 1996||Sep 1, 1998||United States Surgical Corporation||Afterloader provided with remote control unit|
|US6019718 *||May 30, 1997||Feb 1, 2000||Scimed Life Systems, Inc.||Apparatus for intravascular radioactive treatment|
|US6059713 *||Mar 5, 1998||May 9, 2000||Scimed Life Systems, Inc.||Catheter system having tubular radiation source with movable guide wire|
|US6059812 *||Mar 6, 1998||May 9, 2000||Schneider (Usa) Inc.||Self-expanding medical device for centering radioactive treatment sources in body vessels|
|US6071227 *||Jan 27, 1997||Jun 6, 2000||Schneider (Europe) A.G.||Medical appliances for the treatment of blood vessels by means of ionizing radiation|
|US6074338 *||Jun 28, 1994||Jun 13, 2000||Schneider (Europe) A.G.||Medical appliances for the treatment of blood vessels by means of ionizing radiation|
|US6099454 *||Mar 6, 1997||Aug 8, 2000||Scimed Life Systems, Inc.||Perfusion balloon and radioactive wire delivery system|
|US6110097 *||Mar 6, 1997||Aug 29, 2000||Scimed Life Systems, Inc.||Perfusion balloon catheter with radioactive source|
|US6117065 *||Jun 24, 1998||Sep 12, 2000||Scimed Life Systems, Inc.||Perfusion balloon catheter with radioactive source|
|US6146322 *||Oct 30, 1996||Nov 14, 2000||Schneider (Europe) Ag||Irradiating filament and method of making same|
|US6203485||Oct 7, 1999||Mar 20, 2001||Scimed Life Systems, Inc.||Low attenuation guide wire for intravascular radiation delivery|
|US6231494||Nov 17, 1997||May 15, 2001||Schneider (Europe) A.G.||Medical device with radiation source|
|US6234951||Jan 10, 1997||May 22, 2001||Scimed Life Systems, Inc.||Intravascular radiation delivery system|
|US6258019||Sep 8, 1999||Jul 10, 2001||Scimed Life Systems, Inc.||Catheter for intraluminal treatment of a vessel segment with ionizing radiation|
|US6264596||Nov 3, 1997||Jul 24, 2001||Meadox Medicals, Inc.||In-situ radioactive medical device|
|US6267775||Mar 6, 2000||Jul 31, 2001||Schneider (Usa) Inc.||Self-expanding medical device for centering radioactive treatment sources in body vessels|
|US6302865||Mar 13, 2000||Oct 16, 2001||Scimed Life Systems, Inc.||Intravascular guidewire with perfusion lumen|
|US6352501||Sep 23, 1999||Mar 5, 2002||Scimed Life Systems, Inc.||Adjustable radiation source|
|US6398708||Oct 28, 1998||Jun 4, 2002||Scimed Life Systems, Inc.||Perfusion balloon and radioactive wire delivery system|
|US6398709||Oct 19, 1999||Jun 4, 2002||Scimed Life Systems, Inc.||Elongated member for intravascular delivery of radiation|
|US6413203||Sep 16, 1998||Jul 2, 2002||Scimed Life Systems, Inc.||Method and apparatus for positioning radioactive fluids within a body lumen|
|US6416457||Mar 9, 2000||Jul 9, 2002||Scimed Life Systems, Inc.||System and method for intravascular ionizing tandem radiation therapy|
|US6422989||Nov 5, 1999||Jul 23, 2002||Scimed Life Systems, Inc.||Method for intravascular radioactive treatment|
|US6514191||Jan 25, 2000||Feb 4, 2003||Schneider (Europe) A.G.||Medical appliances for the treatment of blood vessels by means of ionizing radiation|
|US6582352||Jan 2, 2001||Jun 24, 2003||Schneider (Europe) A.G.||Medical appliance for treatment by ionizing radiation|
|US6599230||Mar 14, 2001||Jul 29, 2003||Scimed Life Systems, Inc.||Intravascular radiation delivery system|
|US6616629||Jun 14, 1999||Sep 9, 2003||Schneider (Europe) A.G.||Medical appliance with centering balloon|
|US6635008||Jun 4, 1999||Oct 21, 2003||Interventional Therapies Llc||System and method for delivering a medical treatment to a treatment site|
|US6676590||Dec 8, 1997||Jan 13, 2004||Scimed Life Systems, Inc.||Catheter system having tubular radiation source|
|US6869390||Nov 13, 2001||Mar 22, 2005||Mentor Corporation||Automated implantation system for radioisotope seeds|
|US7959548||Mar 22, 2005||Jun 14, 2011||Core Oncology, Inc.||Automated implantation system for radioisotope seeds|
|US9149653||Mar 6, 2013||Oct 6, 2015||Mark A. D'Andrea||Brachytherapy devices and methods for therapeutic radiation procedures|
|US9192345||Mar 11, 2013||Nov 24, 2015||Mark A. D'Andrea||Radiation devices and methods|
|US9299467||Aug 8, 2014||Mar 29, 2016||Bracco Diagnostics Inc.||Infusion system with radioisotope detector|
|US9299468||Aug 8, 2014||Mar 29, 2016||Bracco Diagnostics Inc.||Radioisotope generator system including activity measurement and dose calibration|
|US9597053||Jun 11, 2008||Mar 21, 2017||Bracco Diagnostics Inc.||Infusion systems including computer-facilitated maintenance and/or operation and methods of use|
|US9604074||Mar 15, 2013||Mar 28, 2017||Mark A. D'Andrea||Radiation treatment sheet devices and methods|
|US9607722||Jun 11, 2009||Mar 28, 2017||Bracco Diagnostics Inc.||Infusion systems including computer-facilitated maintenance and/or operation and methods of use|
|US9717844||Jan 2, 2014||Aug 1, 2017||Bracco Diagnostics Inc.||Cabinet structure configurations for infusion systems|
|US9750869||Dec 22, 2016||Sep 5, 2017||Bracco Diagnostics, Inc.||Integrated strontium-rubidium radioisotope infusion systems|
|US9750870||Apr 18, 2017||Sep 5, 2017||Bracco Diagnostics, Inc.||Integrated strontium-rubidium radioisotope infusion systems|
|US20020099255 *||Nov 7, 2001||Jul 25, 2002||Liprie Sam F.||Afterloader apparatus|
|US20030018232 *||Nov 13, 2001||Jan 23, 2003||Mentor Corporation||Automated implantation system for radioisotope seeds|
|US20040254419 *||Jun 14, 2004||Dec 16, 2004||Xingwu Wang||Therapeutic assembly|
|US20050209499 *||Mar 22, 2005||Sep 22, 2005||Mentor Corporation||Automated implantation system for radioisotope seeds|
|US20070010702 *||Jun 30, 2005||Jan 11, 2007||Xingwu Wang||Medical device with low magnetic susceptibility|
|DE3335438A1 *||Sep 30, 1983||Apr 18, 1985||Kurt Dr Sauerwein||Strahlenbehandlungsgeraet|
|DE3442762A1 *||Nov 23, 1984||Jun 26, 1986||Puthawala Anwer||Ferngesteuerte afterloading vorrichtung zur brachycurie-therapie von tumoren|
|EP0012004A1 *||Nov 26, 1979||Jun 11, 1980||Tech/Ops, Inc.||Apparatus for manipulating a quantity of radioactive material between a stored position and a use position|
|EP0138088A1 *||Sep 19, 1984||Apr 24, 1985||Kurt Dr. Sauerwein||Radiation treatment device|
|EP0185939A1 *||Nov 22, 1985||Jul 2, 1986||Anwer Dipl.-Ing. Puthawala||Remotely controlled after-loading device, especially for brachycurie therapy of cancers|
|EP0366214A2 *||Oct 27, 1989||May 2, 1990||Van 't Hooft, Eric||Improved adaptor for remote after-loading apparatus for radiotherapy|
|EP0366214A3 *||Oct 27, 1989||Feb 26, 1992||Van 't Hooft, Eric||Improved adaptor for remote after-loading apparatus for radiotherapy|
|U.S. Classification||250/497.1, 976/DIG.353|
|International Classification||G21F5/02, A61N5/10, A61M36/04, A61M36/00, G21F5/00, G21K5/02|
|Cooperative Classification||A61N5/1007, G21F5/02, A61N2005/1008|
|European Classification||A61N5/10B2, G21F5/02|
|Sep 25, 1986||AS02||Assignment of assignor's interest|
Owner name: COMMISSARIAT A L ENERGIE ATOMIQUE
Owner name: COMPAGNIE ORIS INDUSTRIE, S.A., 31-33 RUE DE LA FE
Effective date: 19860905
|Sep 25, 1986||AS||Assignment|
Owner name: COMPAGNIE ORIS INDUSTRIE, S.A., 31-33 RUE DE LA F
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST.;ASSIGNOR:COMMISSARIAT A L ENERGIE ATOMIQUE;REEL/FRAME:004608/0721
Effective date: 19860905
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:COMMISSARIAT A L ENERGIE ATOMIQUE;REEL/FRAME:004608/0721