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Publication numberUS3874380 A
Publication typeGrant
Publication dateApr 1, 1975
Filing dateMay 28, 1974
Priority dateMay 28, 1974
Publication numberUS 3874380 A, US 3874380A, US-A-3874380, US3874380 A, US3874380A
InventorsRonald Baum
Original AssigneeSmithkline Corp
Export CitationBiBTeX, EndNote, RefMan
External Links: USPTO, USPTO Assignment, Espacenet
Dual nozzle intranasal delivery device
US 3874380 A
Abstract
A dual nozzle intranasal delivery device has a housing having a cavity for the reception of a container, an opening for the reception of a syringe nozzle, and a passage connecting said cavity and said opening. A hollow needle is secured in the passage and extends into the cavity, said needle being adapted to penetrate the stopper of the container. A pair of adjacent spray nozzles having substantially parallel axes are in communication with a conduit in the housing which has an opening for the reception of a syringe nozzle.
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United States Patent Inventor: Ronald Baum, Merion, Pa.

Smithkline Corporation, Philadelphia, Pa.

Filed: May 28, 1974 Appl. No.: 473,372

Assignee:

References Cited UNITED STATES PATENTS 9/1902 Gundlach et a1. 128/235 Baum Apr. 1, 1975 [54] DUAL NOZZLE INTRANASAL DELIVERY 1,930,929 10/1933 Eisenberg .Q. 128/235 DEVICE 3,330,277 7/1967 Gabriels 128/218 R Primary E.\'aminer Richard A. Gaudet Assistant Examiner-Henry J, Recla Attorney, Agent, or Firm -Smith, Harding, Earley & Follmer [5 7] AB STRA CT A dual nozzle intranasal delivery device has a housing having a cavity for the reception of a container, an opening for the reception of a syringe nozzle, and a passage connecting said cavity and said opening. A hollow needle is secured in the passage and extends into the cavity, said needle being adapted to penetrate the stopper of the container. A pair of adjacent spray nozzles having substantially parallel axes are in communication with a conduit in the housing which has an opening for the reception of a syringe nozzle.

1 Claim, 4 Drawing Figures Z ATENTED APR 1 FIG.4.

DUAL NOZZLE INTRANASAL DELIVERY DEVICE BACKGROUND OF THE INVENTION It is known to employ a pair of adjacent spray nozzles communicating with a conduit which is adapted to be connected to a syringe to deliver vaccine such as a flu vaccine or a measles vaccine in about equal doses to each nostril. While this operation is simple and effective, it still leaves the patient with a difficult problem in getting the dosage in liquid form in the syringe. This is particularly the case where the biological to be employed is lyophilized. In accordance with this invention a lyophilized medicament can be placed in solution in a syringe under sterile conditions with great ease by an unskilled patient.

BRIEF SUMMARY OF THE INVENTION A dual nozzle intranasal delivery device has a housing having a cavity for the reception of a container, an opening for the reception ofa syringe nozzle, and a passage connecting said cavity and said opening. A hollow needle is secured in the passage and extends into the cavity, said needle being adapted to penetrate the stopper of the container. A pair of adjacent spray nozzles having substantially parallel axes are in communication with a conduit in the housing which has an opening for the reception of a syringe nozzle.

BRIEF DESCRIPTION OF THE DRAWINGS FIG. 1 is an exploded view of an intranasal delivery device in accordance with the invention together with a container and a syringe;

FIG. 2 is a section through the intranasal device of FIG. 1;

FIG. 3 is a view of the intranasal device of FIG. 1 taken on the plane indicated by the line 3-3 in FIG. 2; and

FIG. 4 is an elevational view of the intranasal device of FIG. 1 shown together with a syringe.

DETAILED DESCRIPTION An intranasal device 2 has a housing 4 provided with a cylindrical cavity 6 adapted to receive a container 8 typically containing a tablet 10 of a lyophilized biological. Container 10 is of a type well known to the art and has a pierceable rubber stopper 14 which is held in position by a metal cap 16. Any of the wide variety of containers currently employed with syringes provided with a needle for piercing a container stopper may be employed.

Housing 4 has a passage 18 in which a hollow needle 20 is secured by a pressed fit. Needle 20 extends into 40 is in communication with a. conduit 44 which has a pair of branches 46 and 48. A pair of spray nozzles 52 and 54 are substantially parallel and spaced apart a distance to permit one spray nozzle to enter each nostril. Each of the spray nozzles has a cap 56 having a discharge passage 58, the passages 58, 58 being substantially parallel. Each cap 56 has an interior opening 60 which is adapted to receive branches 46 and 48 respectively and a bead 62 adapted to snap into grooves 64 and 66 respectively in branches 46 and 48. Branch 46 has a side opening 70 which discharges into cavity 72 in the cap 56 mounted on branch 46. Similarly branch 48 has a side discharge opening 74 which discharges into cavity 76 of the cap 56 mounted on branch 48. The spray nozzles per se are conventional and any spray nozzles conventionally used for spraying liquids into the nose may be employed.

OPERATION Assuming that a lyophilized biological such as the tablet 10 is to be administered, container 8 is inserted into cavity 6 and thrust home causing needle 20 to pierce the pierceable rubber stopper l4 and extend into the interior of container 8.. With nozzle 28 pointing upwardly, cover 32 is removed from nozzle 28 of syringe 30 which contains a suitable reconstituting liquid and the nozzle 28 is inserted into opening 26. Plunger 34 is then advanced to force the reconstituting liquid from syringe 30 into container 8. When the biological tablet 10 has dissolved in the reconstituting liquid, plunger 34 is retracted to draw the thus formed solution into the syringe 30. The syringe 30 is now withdrawn from opening 26 and its nozzle is inserted into opening 40. With the spray nozzles 52 and 54 inserted into the patients nostrils, plunger 34 is depressed so as to force the contained liquid into conduit 44 and equally through branches 46 and 48 and through spray nozzles 52 and 54.

It will be understood that the foregoing description is illustrative and not limiting.

I claim:

1. A dual nozzle intranasal delivery device compris ing:

a housing,

said housing having a cavity for the reception of a container having a pierceable stopper,

an opening for the reception of a syringe nozzle and a passage connecting said cavity and said opening, a hollow needle secured in said passage by a pressed fit and extending into the cavity, said needle being adapted to penetrate the stopper of said container,

a pair of adjacent nozzles having substantially parallel axes,

said housing having a conduit communicating with said nozzles and having a second opening for the reception of a syringe nozzle, and a second passage connecting said second opening with said nozzles, whereby liquid can be introduced into and withdrawn from a container and then discharged through the nozzles.

Patent Citations
Cited PatentFiling datePublication dateApplicantTitle
US708224 *Oct 18, 1901Sep 2, 1902Frank C GundlachSyringe.
US1930929 *May 12, 1931Oct 17, 1933Eisenberg Moses JoelHypodermic implement
US3330277 *Aug 17, 1964Jul 11, 1967Scherer Corp R PMultidose hypodermic injector
Referenced by
Citing PatentFiling datePublication dateApplicantTitle
US3933155 *Jan 23, 1975Jan 20, 1976Mizzy Inc.Pressure injector apparatus having improved trigger mechanism
US4475915 *Oct 13, 1983Oct 9, 1984Sloane Glenn LHolder for a syringe and an ampoule
US5026357 *Mar 21, 1989Jun 25, 1991Schering AgInjection device
US5240047 *May 6, 1992Aug 31, 1993Hedges Harry SSyringe guide and bottle holder
US5433191 *Dec 6, 1993Jul 18, 1995Habley Medical Technology Corp.Medication sprayer
US5505236 *Apr 4, 1994Apr 9, 1996Abbott LaboratoriesAnesthetic vaporizer filling system
US5601077 *Aug 7, 1991Feb 11, 1997Becton, Dickinson And CompanyNasal syringe sprayer with removable dose limiting structure
US5894870 *Jun 10, 1997Apr 20, 1999Pharmacia & Upjohn CompanySyringe guide and vial holder
US5899202 *Jun 28, 1996May 4, 1999Unisia Jecs CorporationMedicine administering device for nasal cavities and method of using same
US5961489 *Mar 10, 1998Oct 5, 1999Shinko Kagaku Kabushiki KaishaSpray adaptors for spraying collunarium and sprayers employing the spray adaptors
US6382204Oct 14, 1999May 7, 2002Becton Dickinson And CompanyDrug delivery system including holder and drug container
US6431172 *Oct 20, 2000Aug 13, 2002Mallinckrodt Inc.Nasal cannula with inflatable plenum chamber
US6530371Nov 5, 2001Mar 11, 2003Becton, Dickinson And CompanyDrug delivery system including holder and drug container
US6585016Mar 15, 2002Jul 1, 2003Datex-Ohmeda, Inc.Keyed anesthetic vaporizer filling system
US6718969 *May 28, 2002Apr 13, 2004Darren RubinMedication dosage inhaler system
US6779566 *Jan 14, 2003Aug 24, 2004Access Business Group International LlcConnector device for sealing and dispensing freeze-dried preparations
US6817390Jun 26, 2003Nov 16, 2004Datex-Ohmeda, Inc.Keyed anesthetic vaporizer filling system
US6929041May 13, 2004Aug 16, 2005Datex-Ohmeda, Inc.Keyed anesthetic vaporizer filling system
US7213593Jul 11, 2005May 8, 2007Boehringer Ingelheim KgTwo-chamber cartridge for propellant-free metering aerosols
US7270127 *Sep 3, 2002Sep 18, 2007Becton, Dickinson And CompanyMedicament respiratory delivery device
US7296566May 2, 2002Nov 20, 2007Becton, Dickinson And CompanyNasal delivery device including spray nozzle
US7793655Sep 14, 2010Boehringer Ingelheim Pharma Gmbh & Co. KgTwo-chamber cartridge for propellant-free metering aerosols
US7980243Jun 7, 2007Jul 19, 2011Boehringer Ingelheim Pharma Gmbh & Co., KgTwo-chamber cartridge for propellant-free metering aerosols
US20030047184 *Sep 3, 2002Mar 13, 2003Lockhart Artis R.Medicament respiratory delivery device
US20040089375 *Jun 26, 2003May 13, 2004Datex-Ohmeda, Inc.Keyed anesthetic vaporizer filling system
US20040134562 *Jan 14, 2003Jul 15, 2004Engel Steven P.Connector device for sealing and dispensing freeze-dried preparations
US20040206417 *May 13, 2004Oct 21, 2004Falligant John C.Keyed anesthetic vaporizer filling system
US20050241634 *Jul 11, 2005Nov 3, 2005Dieter HochrainerTwo-chamber cartridge for propellant-free metering aerosols
US20110083665 *Apr 14, 2011Wolfe Tory Medical, Inc.Vial multi-access adapter
US20130269684 *Mar 14, 2013Oct 17, 2013Dance Pharmaceuticals, Inc.Methods and systems for supplying aerosolization devices with liquid medicaments
US20140124087 *Feb 27, 2013May 8, 2014Nordson CorporationFluid delivery assemblies for withdrawing biomaterial fluid from a vial and for dispensing the biomaterial fluid, fluid control devices therefor, and related methods
WO1997039831A1 *Apr 18, 1997Oct 30, 1997Boehringer Ingelheim Pharma KgTwo-chamber cartridge for propellant-free metered aerosols
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WO2015104511A1Jan 9, 2015Jul 16, 2015Aptar France SasMethod for using an assembly for dispensing a fluid product
Classifications
U.S. Classification128/200.14, 141/383, 141/329, 604/94.1, 141/27, 128/203.21, 604/414, 604/201, 128/203.22
International ClassificationA61M15/00, A61M15/08
Cooperative ClassificationA61M2202/0468, A61M15/0028, A61M16/0666, A61M15/08, A61M2011/007, A61M2205/073, A61M2015/0036
European ClassificationA61M15/08, A61M15/00C
Legal Events
DateCodeEventDescription
Jun 21, 1982ASAssignment
Owner name: SMITHKLINE BECKMAN CORPORATION
Free format text: CHANGE OF NAME;ASSIGNOR:SMITHKLINE CORPORATION;REEL/FRAME:004080/0769
Effective date: 19820304
Owner name: SMITHKLINE BECKMAN CORPORATION, PENNSYLVANIA