|Publication number||US3882863 A|
|Publication date||May 13, 1975|
|Filing date||Aug 1, 1973|
|Priority date||Aug 1, 1973|
|Also published as||DE2436000A1, DE2436000C2|
|Publication number||US 3882863 A, US 3882863A, US-A-3882863, US3882863 A, US3882863A|
|Inventors||Calkins George B, Sarnoff Stanley J|
|Original Assignee||Survival Technology|
|Export Citation||BiBTeX, EndNote, RefMan|
|Patent Citations (8), Referenced by (145), Classifications (9), Legal Events (4)|
|External Links: USPTO, USPTO Assignment, Espacenet|
United States Patent 1191 Sarnoff et al.
[ ]*May 13, 1975  HYPODERMIC INJECTION DEVICE 3,403,679 10/1968 Sinclair et a1. 128/218 F A COVERED WITH 3,702,609 11 1972 Steiner 128/218 F 3,712,301 1/1973 Sarnoff 128/218 F  Inventors: Stanley J. Sarnoff; George B. FOREIGN PATENTS OR APPLICATIONS Calkins, both f Bethesda Md 1,514,210 H1968 France 128/218 F  Assignee: Survival Technology, Inc., Bethesda, Primary Examiner Richard Gaudet Assistant Examiner-J. C. McGowan =1 1 Notice; The portion of the term of this Attorney, Agent, or Firm-Witherspoon and Lane patent subsequent to Mar. 19, 1991, has been disclaimed. 1 1 B RACT A hypodermic injection device comprising a cartridge 2 F A 1 73 2] fled 9 holder havmg a cylmdncal body open at one end and  Appl. No.: 384,682 closed at the other end, the closed end being provided with an aperture, a cartridge including an ampoule l. 12 with attached cannula Within the holder the cannula 4 5 5 being directed toward the holders closed end, the am-  Fie'ld 218 DA poule including a cylindrical sleeve slidably carrying a 128/218 NV M R piston, the sleeve being open at one end and having a 218 g necked portion at the other end to receive a hub mounting the cannula, fluid medicament in the sleeve between the piston and cannula, a spring power as-  References cued sembly for moving the cartridge forward and for in- UNITED STATES PATENTS jecting the fluid medicament carried in the ampoule, a 2,752,918 7/1956 Uytenbogaart 128/218 F afety assembly for controlling actuation of the spring 2,847,995 8/1958 Adams 128/218 N power assembly, and a resilient sheath Covering the ;6 cannula to maintain the cannula in sterile condition. 3:136:313 6/1964 EnstrBm et a1. 128/218 F 7 Claims, 3 Drawing Figures 2|4 lo I06 164 I38 I29 101 113 2 so 136 14s PATENTEU HAY 1 ems 882,863
HYPODERMIC INJECTION DEVICE HAVING CANNULA COVERED WITH RESILIENT SHEATH SUMMARY OF THE INVENTION This invention relates to injection devices of the gun type wherein spring power means drives an ampoule and cannula to insert the cannula and then inject the medicament. The cannula is provided with a resilient sheath to maintain the cannula in sterile condition at 'all times prior to injection.
In the device of this invention, the ampoule and attached cannula are slidably carried in a cylindrical holder which is closed at the end housing the cannula except for an aperture through which the cannula passes when the unit is actuated. A spring power assembly drives a plunger which engages the ampoule to drive the ampoule and cannula forward causing the cannula to travel out through the aperture in the closed end of the cylindrical holder and to enter the locus which is to receive the fluid medicament. Continued movement of the plunger, after placing of the cannula in the locus, forces a piston in the ampoule forwardly to inject the medicament. During this action, the resilient sheath positioned on and over the cannula is held within the closed end of the cylindrical holder and is pierced by the end of the cannula as it proceeds forwardly. As the cannula continues forward, the sheath is compressed between the closed end of the cylindrical holder and the cannula hub. This action continues until the cannula is fully extended, at which time the sheath is not quite fully compressed, thus making it possible for the sheath to act as a shock absorber at all times during forward travel of the cannula. Toward the end of injection, the forward travel of the power spring is such that its energy is less than that now stored in the compressed sheath. Therefore, a. slight retraction of the cannula occurs during the terminal portion of the injection.
In view of the foregoing, it is an object of this invention to provide a gun type injection device with a resilient cannula sheath for maintaining the cannula in sterile condition at all times prior to actuation.
It is another object of this invention to provide a gun type injection device with a resilient cannula sheath to act as a shock absorber during operation of the device.
It is a further object of this invention to provide a gun type injection device wherein the cannula is covered by a resilient sheath which upon being compressed when the device is actuated will react to retract the cannula a small distance during the terminal portion of injection.
IN THE DRAWINGS FIG. 1 is a longitudinal broken away view, partly in section, illustrating the sheath as applied to the cannula when the injection device is in ready position;
FIG. 2 is a view similar to FIG. 1, showing the compressed sheath after firing of the injection device with the cartridge fully projected and just prior to the forward movement of the plunger and injection of the medicament; and
FIG. 3 is a view similar to FIG. 2, illustrating a slight retraction of the cannula from the fully extended position of FIG. 2 which .retraction occurs during the terminal portion of the injection.
DETAILED DESCRIPTION OF THE INVENTION 0 open end. A cartridge assembly 106 is assembled in the shouldered end of the outer sleeve 100. The cartridge assembly 106 includes a cartridge holder sleeve 104 fitted within the sleeve 100 and having a decreased forward end portion 153 forming a shoulder 154 which fits against seat 112 provided by outer sleeve shoulder 110. The extreme forward end portion 156 of the holder sleeve 104 is tapered to form a small circular aperture.
The cartridge 135 includes an ampoule cylinder 136 with liquid medicament 146 there within and a piston 148 at one end with a cannula 150 at the other end. The ampoule cylinder 136 has a necked portion with a diameter less than that of the cylinder I36 and terminates in an enlarged annular flange. The cannula 150 is secured to a cannula hub 81 which in turn is affixed to the enlarged flange on the necked portion 80. More specifically, cannula hub 81 comprises a reduced diameter portion 84 which is secured to cannula 150 and an intermediate body 86 connected to enlarged body 88. The enlarged body 88 fits over and is secured to the annular flange of the necked portion 80 of the ampoule cylinder. Within the neck of the ampoule cylinder 136, between the inner end of the cannula 150 and the medicament, there may be interposed a fluid pressure rupturable diaphragm generally like that described in US. Pat. No. 3,391,695 to Sarnoff.
The cartridge assembly 106 is assembled in the outer sleeve with the cannula 150 spaced from the apertured end of the holder 104. The overall length of the ampoule and cannula is such that it is all contained within the holder sleeve 104, as illustrated in FIG. 1.
The outer sleeve 100 is of such length that it accommodates the cartridge assembly 106 in one end and receives the gun assembly 200 in the other to complete the device. The gun assembly 200 comprises an inner gun sleeve 101 having an out turned flange 103 which fits up against the end of the cartridge holder sleeve 104 when the gun assembly is inserted in the outer sleeve 100. The other end of the inner gun sleeve 101 is centrally apertured to form a hole 120. The rear outer face 122 of the inner gun sleeve 10] is planar and perpendicular to the longitudinal axis of the sleeve for a purpose to be brought out later.
A plunger 162 fits within the out turned flange end of the inner gun sleeve 101. This plunger has a cylindrical body portion 163 and a circular head portion 164 of a diameter larger than the body portion 163 and generally slightly less than that of the piston 148 in the ampoule 135. The head 164 has an opening which is sized to align and correspond to the through hole 166 in the plunger body 163. The plunger head 164 is provided with a plurality of circumferentially spaced, radially extending tabs 168. These tabs 168 form a diameter greater than that of the plunger head 164 so that the tabs will engage the end of the ampoule cylinder 136.
' Longitudinal slots 172 are formed in the plunger head 164 immediately behind the tabs 168. These slots are sized so that they will accommodate the tabs 168 when they are later broken off or bent rearwardly in the operation of the device. These slots extend throughout the length of the head behind the tabs.
Referring to FIGS. 1 and 2, a locking detent 176 is fitted through the hole 166 in the plunger 162 and has a central body portion 178 with outwardly extending lugs 180 on one end fitting an annular shoulder 182 of the plunger head 164. The other end of the locking detent 176 is provided with four equally spaced, longitudinally extending springy detent arms terminating in frusto-conical detent heads 186. This locking detent 176 maintains the plunger 162 and inner gun sleeve 101 in assembled position with a coil spring 138 compressed therebetween as follows: A coil spring 138 is positioned over the plunger body 163 and abuts the plunger head 164 at one end and the inner face of the end wall of the inner sleeve 101 at the other. Upon compressing of the coil spring 138 sufficiently, the detent heads 186 will be cammed inwardly by engaging the periphery of the end wall opening 120 and pass therethrough whereupon the bases of the detent heads 186 will come to rest on the planar face 122 of the inner gun sleeve 101 to retain the plunger and inner gun sleevein assembled condition with the coil spring 138 compressed therebetween. When desired, the rear planar surface 122 of the inner sleeve 101 may be overlaid with a metal washer 127, in which case it is advan tageous to provide a guide and holding flange 128 to surround the opening 120. The flange 128 is provided with a lip portion to retain the washer in place.
As illustrated in FIGS. 1 and 2, the inner gun sleeve 101 has a plurality of longitudinally extending raised ribs 129 running from the flange 103 approximately one-half the length of the said sleeve. An outer gun sleeve 192 fits over inner gun sleeve 101 and is sized to frictionally engage ribs 129. The outer sleeve 192 has a closed end 194 with a central aperture 196 from which extends a frusto-conical cam surface 198 sized and shaped to cooperate with frusto-conical detent heads 186 to cam said heads radially inwardly. The outer gun sleeve 192 is provided with a circumferential locking rib 199 which fits in groove 113 in the outer sleeve 102 to retain the gun assembly 200 in position in said outer sleeve. It should be noted that the length of outer gun sleeve 192 is slightly less than that of the inner gun sleeve 101 so as to make certain that there will be space between the inner wall of the outer gun sleeve 192 and the flange 103 of the inner gun sleeve 101 so that the two gun sleeves may move relative to each other to ca'm frusto-conical detent heads 186 inwardly in operating the device.
In order to make certain that the frusto-conical detent heads 186 are not accidentally cammed inwardly, a safety pin assembly is provided. This safety pin assembly comprises a cap 142 having a cylindrical sleeve 143 sized to fit over the end portion of outer gun sleeve 192. A safety pin 144 extends inwardly from the center of the cap 142 into the opening formed by the inner portions of the detent heads 186 to thereby prevent inward movement of said detent heads. The cap 142 is provided internally with a plurality of spacer abutments 145 to assure proper positioning of the cap on the outer abuts the shoulder 82 formed by hub portions 84 and 86. The length of the sheath is such that its closed end is slightly beyond or spaced from the end of cannula 150. In order to make certain that the sheathed cannula is maintained in proper alignment with aperture 158, a plurality of ribs 157 is formed on the inner face of tapered holder portion 156 surrounding said aperture. Thus, the end of the sheath 250 is held in necessary alignment by bearing against the converging section of the ribs 157.
Upon the actuation of the injection device, the cartridge assembly 106 moves forward whereby the sheath 250 is compressed between the cannula end of the cartridge holder sleeve 104 and the hub shoulder 82, as illustrated in FIG. 2. The cannula sheath, in being compressed, acts as a shock absorber to gradually absorb some of the energy provided by the power spring 138 as it drives the cartridge assembly 106 forward. It should be noted that at no time, even when the cannula is fully extended, is the sheath compressed to such an extent that it would act as a solid and thereby provide no shock absorbing in such a condition.
When the cannula 150 is fully extended as shown in FIG. 2, the cannula sheath 250 will be compressed the greatest amount hence the largest reactionary force will exist in the compressed sheath in such position. As illustrated in FIG. 2, the cartridge has completed its travel under the force of spring 138 and the forward movementaof piston 148 commences under the action of spring 138 to start the injection cycle. The size of the sheath is such that in the maximum compressed condition, as in FIG. 2, the forces stored in the sheath are greater than those in spring 138 when it has reached a point just short of full piston travel. At this point the compressed sheath 250 takes over and causes the cartridge 135 and attached cannula 150 to retract slightly, as shown in FIG. 3, while the last stage of injection takes place. It is at this stage that the forces of the compressed sheath and the spring 138 are counterbalanced.
The importance of the sheath 250 and its multiple features is even more important when consideration is taken of the fact that most of the ampoule cylinders (i.e. cylinder 136 of the device illustrated) are made of glass and hence are subject to breakage under certain amounts and types of shock. The shock absorbing feature enjoyed by the use of the cannula sheath of this invention contributes substantially to overall quality and reliability. Furthermore, the covering of the cannula with the sheath provides greater ease in assembly since it is not necessary to maintain any of the inner portions of the holder and associated elements in sterile condition.
The type of material from which the sheath 250 can be made varies substantially. Even so, the preferred material would be one having good resilient characteristics such as various types of rubber and synthetics. Shelf life is also important. By this it is meant that the material should retain its characteristics over a substantial period of time and under varied conditions.
What is claimed is:
1. In a hypodermic injection device comprising a gun, a cartridge holder in operative relationship to the gun, a cartridge within the holder, said gun comprising a sleeve open at one end thereof, a plunger positioned within the sleeve, spring power means acting on said plunger tending to move it out the open end of the sleeve, restraining means cooperating with said plunger to prevent plunger movement, safety means acting on said restraining means to render it inoperative, said cartridge holder comprising a hollow shell acting as a prolongation of the gun sleeve, said cartridge including an ampoule comprising a hollow cylindrical sleeve, a piston slidably positioned in one end thereof and means mounting a cannula extending from and closing off the other end, a fluid within the cylindrical sleeve between the piston and the cannula, the cartridge fitting within the cartridge holder with the free end of the cannula within the end of the holder remote from the gun, the improvement comprising:
a resilient sheath covering the cannula, said sheath having a closed end and an open end, the length of the sheath being sized such that when assembled on the cannula the closed end of the sheath is not pierced by the cannula end, and means for preventing forward movement of the closed end of the sheath whereby when the power means forces the cartridge forward the cannula will pierce the closed end of the sheath and deliver the fluid medicament from the ampoule sleeve.
2. The invention as set forth in claim 1 and wherein the resilient sheath comprises a resilient cylinder having a closed and an open end, the length of the sheath being sized such that the closed end thereof is spaced from the cannula end.
3. The invention as set forth in claim 1 and wherein the resilient sheath is so sized that upon forward movement of the cartridge, the sheath will be compressed between the cannula hub and the forward end of the cartridge holder and act as a shock absorber.
4. The invention as set forth in claim 3 and wherein the size of the resilient sheath is such that it is never fully compressed, even when the cartridge is fully extended.
5. The invention as set forth in claim 4 and wherein means are provided in the forward end of the cartridge holder for centrally positioning the closed end of the resilient sheath in the cartridge holder.
6. The invention as set forth in claim 1 and wherein the resilient sheath is so sized that when it is compressed by the full extension of the cartridge under action of the power means the reactionary energy stored in the compressed sheath will overcome the force of the power means and retract the cannula a small distance.
7. The invention as set forth in claim 3 and wherein
|Cited Patent||Filing date||Publication date||Applicant||Title|
|US2752918 *||May 1, 1952||Jul 3, 1956||Auguste Rooseboom||Hypodermic injection apparatus|
|US2847995 *||Aug 23, 1954||Aug 19, 1958||Becton Dickinson Co||Transfusion needle sheath|
|US2866458 *||May 9, 1956||Dec 30, 1958||Becton Dickinson Co||Hypodermic assembly|
|US2888924 *||Feb 25, 1958||Jun 2, 1959||Russell P Dunmire||Hypodermic syringes|
|US3136313 *||Feb 14, 1961||Jun 9, 1964||Astra Ab||Automatic hypodermic syringe|
|US3403679 *||Dec 10, 1965||Oct 1, 1968||Secr Defence Brit||Hypodermic injection apparatus with a secondary capsule-collapsing means|
|US3702609 *||Nov 19, 1969||Nov 14, 1972||Maurice Steiner||Hypodermic syringes, in particular self-injecting syringes|
|US3712301 *||Jan 11, 1971||Jan 23, 1973||Survival Technology||Gun type hypodermic injector with rapid cartridge displacement within holder|
|Citing Patent||Filing date||Publication date||Applicant||Title|
|US4031893 *||May 14, 1976||Jun 28, 1977||Survival Technology, Inc.||Hypodermic injection device having means for varying the medicament capacity thereof|
|US4394863 *||Oct 23, 1981||Jul 26, 1983||Survival Technology, Inc.||Automatic injector with cartridge having separate sequentially injectable medicaments|
|US4484910 *||Dec 21, 1983||Nov 27, 1984||Survival Technology, Inc.||Dual mode automatic injector|
|US4624660 *||Oct 1, 1985||Nov 25, 1986||Duphar International Research B.V.||Automatic injection device|
|US4658830 *||Aug 8, 1984||Apr 21, 1987||Survival Technology, Inc.||Method and apparatus for initiating reperfusion treatment by an unattended individual undergoing heart attack symptoms|
|US4678461 *||Nov 1, 1984||Jul 7, 1987||Survival Technology, Inc.||Automatic injector with improved glass container protector|
|US4723937 *||May 20, 1985||Feb 9, 1988||Survival Technology, Inc.||Plural dosage automatic injector with a by-pass fitment|
|US4795433 *||Mar 31, 1988||Jan 3, 1989||Survival Technology, Inc.||Automatic injector for emergency treatment|
|US4822340 *||Oct 9, 1986||Apr 18, 1989||Duphar International Research B.V.||Automatic injector|
|US4832682 *||May 20, 1985||May 23, 1989||Survival Technology, Inc.||Injection method and apparatus with electrical blood absorbing stimulation|
|US4902279 *||Oct 5, 1988||Feb 20, 1990||Autoject Systems Inc.||Liquid medicament safety injector|
|US5026349 *||Feb 16, 1990||Jun 25, 1991||Autoject Systems Inc.||Liquid medicament injector system|
|US5085641 *||Apr 12, 1990||Feb 4, 1992||Survival Technology, Inc.||Conveniently carried frequent use auto-injector with improved cap structure|
|US5085642 *||Jul 17, 1989||Feb 4, 1992||Survival Technology, Inc.||Conveniently carried frequent use autoinjector|
|US5092842 *||May 5, 1988||Mar 3, 1992||Wilhelm Haselmeier Gmbh & Co.||Injection device with a cocking element and a second setting element|
|US5092843 *||Apr 12, 1990||Mar 3, 1992||Survival Technology, Inc.||Dispersion multichamber auto-injector|
|US5102393 *||Jul 17, 1989||Apr 7, 1992||Survival Technology, Inc.||Autoinjector converted from intramuscular to subcutaneous mode of injection|
|US5137516 *||Nov 27, 1990||Aug 11, 1992||Glaxo Group Limited||Triggered application device for medicament to be more descriptive of the invention|
|US5167632 *||Jan 24, 1992||Dec 1, 1992||New Potency Products, Inc.||Syringe|
|US5167641 *||May 29, 1991||Dec 1, 1992||Arnis, Inc.||Auto-retracting needle injector system|
|US5273544 *||Jun 10, 1992||Dec 28, 1993||Duphar International Research B.V.||Injection device|
|US5354286 *||Dec 7, 1993||Oct 11, 1994||Survival Technology, Inc.||Injection device having polyparaxylylene coated container|
|US5391151 *||Jan 14, 1992||Feb 21, 1995||Survival Technology, Inc.||Subcutaneous injector|
|US5405362 *||Dec 20, 1993||Apr 11, 1995||The Board Of Regents For The University Of Texas System||Interactive external defibrillation and drug injection system|
|US5478316 *||Feb 2, 1994||Dec 26, 1995||Becton, Dickinson And Company||Automatic self-injection device|
|US5599315 *||Dec 1, 1995||Feb 4, 1997||Charles J. McPhee||Syringe actuation device|
|US5800405 *||Jan 30, 1997||Sep 1, 1998||I-Flow Corporation||Syringe actuation device|
|US6019747 *||Oct 21, 1997||Feb 1, 2000||I-Flow Corporation||Spring-actuated infusion syringe|
|US6629958 *||Jun 7, 2000||Oct 7, 2003||Ronald P. Spinello||Leak sealing needle|
|US6669673||Jun 5, 2002||Dec 30, 2003||Icu Medical, Inc.||Medical valve|
|US6682509||Nov 19, 2001||Jan 27, 2004||Icu Medical, Inc.||Medical valve and method of use|
|US6712794||Aug 21, 2001||Mar 30, 2004||Spinal Specialties, Inc.||Apparatus for delivering a viscous liquid to a surgical site|
|US6758833||May 22, 2002||Jul 6, 2004||Icu Medical, Inc.||Medical value|
|US6979316||May 23, 2002||Dec 27, 2005||Seedlings Life Science Ventures Llc||Apparatus and method for rapid auto-injection of medication|
|US7314464||Aug 17, 2005||Jan 1, 2008||Becton, Dickinson And Company||Pen needle and safety system|
|US7470258||Mar 13, 2002||Dec 30, 2008||Mdc Investment Holdings, Inc.||Pre-filled safety vial injector|
|US7658724||Mar 24, 2005||Feb 9, 2010||Seedings Life Science Ventures LLC||Apparatus and method for rapid auto-injection of medication|
|US7666164||Dec 7, 2004||Feb 23, 2010||Becton, Dickinson And Company||Pen needle and safety shield system|
|US7695453||Jul 26, 2002||Apr 13, 2010||Owen Mumford Limited||Injection devices|
|US7713247||May 3, 2006||May 11, 2010||Icu Medical, Inc.||Medical valve and method of use|
|US7713248||May 3, 2006||May 11, 2010||Icu Medical, Inc.||Medical valve and method of use|
|US7713249||May 3, 2006||May 11, 2010||Icu Medical, Inc.||Medical valve and method of use|
|US7717883||May 3, 2006||May 18, 2010||Icu Medical, Inc.||Medical valve and method of use|
|US7717884||May 3, 2006||May 18, 2010||Icu Medical, Inc.||Medical valve and method of use|
|US7717885||May 3, 2006||May 18, 2010||Icu Medical, Inc.||Medical valve and method of use|
|US7717886||May 3, 2006||May 18, 2010||Icu Medical, Inc.||Medical valve and method of use|
|US7717887||May 3, 2006||May 18, 2010||Icu Medical, Inc.||Medical valve and method of use|
|US7722575||May 3, 2006||May 25, 2010||Icu Medical, Inc.||Medical valve and method of use|
|US7722576||May 3, 2006||May 25, 2010||Icu Medical, Inc.||Medical valve and method of use|
|US7794432||Oct 25, 2007||Sep 14, 2010||Meridian Medical Technologies, Inc.||Automatic injector with kickback attenuation|
|US7811254||Apr 20, 2007||Oct 12, 2010||Meridian Medical Technologies, Inc.||Autoinjector with needle depth adapter|
|US7905352||Aug 8, 2005||Mar 15, 2011||Washington Biotech Corporation||Kits containing medicine injection devices and containers|
|US7927303||Oct 9, 2007||Apr 19, 2011||Washington Biotech Corporation||Medicine injection devices and methods|
|US7931618||Oct 31, 2007||Apr 26, 2011||Washington Biotech Corporation||Apparatuses and methods for injecting medicines to a desired depth|
|US8002765||May 3, 2006||Aug 23, 2011||Icu Medical, Inc.||Medical valve with fluid escape space|
|US8048035||Oct 27, 2008||Nov 1, 2011||Meridian Medical Technologies, Inc.||Automatic injector with needle cover|
|US8162887||Mar 25, 2011||Apr 24, 2012||Abbott Biotechnology Ltd.||Automatic injection devices|
|US8187224||Sep 29, 2009||May 29, 2012||Washington Biotech Corporation||Methods performed by medicine injection apparatuses|
|US8366682||Mar 4, 2009||Feb 5, 2013||Washington Biotech Corporation||Medicine injection apparatuses|
|US8449498||Jan 15, 2010||May 28, 2013||Owen Mumford Limited||Relating to injection devices|
|US8636704||Apr 29, 2010||Jan 28, 2014||Abbvie Biotechnology Ltd||Automatic injection device|
|US8668670||Apr 10, 2012||Mar 11, 2014||Abbvie Biotechnology Ltd||Automatic injection devices|
|US8679061||Mar 5, 2008||Mar 25, 2014||Abbvie Biotechnology Ltd||Automatic injection device|
|US8708968||Jan 24, 2012||Apr 29, 2014||Abbvie Biotechnology Ltd.||Removal of needle shields from syringes and automatic injection devices|
|US8758301||Dec 15, 2010||Jun 24, 2014||Abbvie Biotechnology Ltd||Firing button for automatic injection device|
|US8870827||Aug 17, 2010||Oct 28, 2014||Meridian Medical Technologies, Inc.||Automatic injector|
|US8932264||Aug 11, 2003||Jan 13, 2015||Becton, Dickinson And Company||Medication delivery pen assembly with needle locking safety shield|
|US8945063||Jan 17, 2014||Feb 3, 2015||Antares Pharma, Inc.||Hazardous agent injection system|
|US9017287||Dec 17, 2013||Apr 28, 2015||Abbvie Biotechnology Ltd||Automatic injection devices|
|US9144648||May 2, 2007||Sep 29, 2015||Antares Pharma, Inc.||Injector with adjustable dosing|
|US9168562 *||Oct 10, 2013||Oct 27, 2015||Ann Gilchrist||Syringe-assist device and method for utilizing the same|
|US9180244||Apr 21, 2011||Nov 10, 2015||Abbvie Biotechnology Ltd||Wearable automatic injection device for controlled delivery of therapeutic agents|
|US9180259||Feb 5, 2014||Nov 10, 2015||Antares Pharma, Inc.||Prefilled syringe jet injector|
|US9220660||Jul 15, 2011||Dec 29, 2015||Antares Pharma, Inc.||Liquid-transfer adapter beveled spike|
|US9265886||Feb 1, 2013||Feb 23, 2016||Washington Biotech Corporation||Medicine injection apparatuses|
|US9265887||Jan 24, 2012||Feb 23, 2016||Abbvie Biotechnology Ltd.||Automatic injection devices having overmolded gripping surfaces|
|US9333309||Jun 22, 2014||May 10, 2016||Antares Pharma, Inc.||Intradermal injector|
|US9339610||Apr 15, 2014||May 17, 2016||Abbvie Biotechnology Ltd||Removal of needle shield from syringes and automatic injection devices|
|US9364610||May 7, 2013||Jun 14, 2016||Antares Pharma, Inc.||Injection device with cammed ram assembly|
|US9364611||May 7, 2013||Jun 14, 2016||Antares Pharma, Inc.||Needle assisted jet injection device having reduced trigger force|
|US9393367||Apr 3, 2015||Jul 19, 2016||Antares Pharma, Inc.||Prefilled syringes and kits thereof|
|US9446195||Jun 28, 2013||Sep 20, 2016||Antares Pharma, Inc.||Injection device with cammed ram assembly|
|US9486583||Mar 5, 2013||Nov 8, 2016||Antares Pharma, Inc.||Prefilled syringe with breakaway force feature|
|US9486584||Nov 6, 2015||Nov 8, 2016||Abbvie Biotechnology Ltd.||Automatic injection device|
|US9517310 *||Apr 24, 2012||Dec 13, 2016||Sanofi-Aventis Deutschland Gmbh||Pen injector with resetting mechanism for receiving new cartridge during driver decoupling and proximal spindle retraction|
|US9545483 *||Dec 2, 2008||Jan 17, 2017||Sanofi-Aventis Deutschland Gmbh||Drive assembly suitable for use in a medication delivery device and medication delivery device|
|US9561328||Dec 17, 2013||Feb 7, 2017||Abbvie Biotechnology Ltd||Automatic injection device|
|US9561333||Dec 12, 2014||Feb 7, 2017||Antares Pharma, Inc.||Multiple dosage injector|
|US9586010||Mar 7, 2013||Mar 7, 2017||Meridian Medical Technologies, Inc.||Automatic injector with needle cover|
|US9616179 *||May 28, 2010||Apr 11, 2017||Sanofi—Aventis Deutschland GmbH||Resetting mechanism for a drug delivery device|
|US9629959||Jul 13, 2016||Apr 25, 2017||Antares Pharma, Inc.||Prefilled syringe jet injector|
|US9662454 *||Apr 24, 2012||May 30, 2017||Sanofi-Aventis Deutschland Gmbh||Resetting mechanism for a drug delivery device|
|US9687613 *||Apr 24, 2012||Jun 27, 2017||Sanofi-Aventis Deutschland Gmbh||Resetting mechanism for a drug delivery device|
|US9707354||Mar 11, 2014||Jul 18, 2017||Antares Pharma, Inc.||Multiple dosage injector with rack and pinion dosage system|
|US9731079 *||Dec 1, 2009||Aug 15, 2017||Sanofi-Aventis Deutschland Gmbh||Drive assembly suitable for use in a medication delivery device and medication delivery device|
|US9737670||Apr 5, 2016||Aug 22, 2017||Antares Pharma, Inc.||Intradermal injector|
|US9744302||Feb 11, 2014||Aug 29, 2017||Antares Pharma, Inc.||Needle assisted jet injection device having reduced trigger force|
|US9750881||Aug 22, 2016||Sep 5, 2017||Antares Pharma, Inc.||Hazardous agent injection system|
|US9764090||Mar 26, 2015||Sep 19, 2017||Abbvie Biotechnology Ltd||Relating to automatic injection devices|
|US9808582||Apr 4, 2014||Nov 7, 2017||Antares Pharma, Inc.||Two-stage reconstituting injector|
|US20040002684 *||Jun 27, 2003||Jan 1, 2004||Lopez George A.||Fluid transfer device and method of use|
|US20040039337 *||Feb 27, 2003||Feb 26, 2004||Letzing Michael Alexander||Portable safety auto-injector|
|US20040215151 *||Jul 26, 2002||Oct 28, 2004||Jeremy Marshall||Injection devices|
|US20040243070 *||Jul 1, 2004||Dec 2, 2004||Lopez George A.||Medical valve and method of use|
|US20050038392 *||Aug 11, 2003||Feb 17, 2005||Becton, Dickinson And Company||Medication delivery pen assembly with needle locking safety shield|
|US20050171477 *||Mar 24, 2005||Aug 4, 2005||Seedlings Life Science Ventures||Apparatus and method for rapid auto-injection of medication|
|US20050222539 *||Apr 2, 2004||Oct 6, 2005||Pediamed Pharmaceuticals, Inc.||Automatic injection device|
|US20050277895 *||Aug 17, 2005||Dec 15, 2005||Becton, Dickinson And Company||Pen needle and safety system|
|US20050283115 *||Dec 7, 2004||Dec 22, 2005||Lucio Giambattista||Pen needle and safety shield system|
|US20060178634 *||Aug 8, 2005||Aug 10, 2006||Wyrick Ronald S||Medicine injection devices and methods|
|US20070017533 *||May 5, 2006||Jan 25, 2007||Washington Biotech Corporation||Method and apparatus for delivering epinephrine|
|US20070203247 *||Feb 28, 2007||Aug 30, 2007||Elaine Phillips||Epinephrine dosing regimens|
|US20070293582 *||Jun 5, 2007||Dec 20, 2007||Malcolm Hill||Epinephrine dosing regimens comprising buccal, lingual or sublingual and injectable dosage forms|
|US20080039789 *||Oct 9, 2007||Feb 14, 2008||Wyrick Ronald E||Medicine injection devices and methods|
|US20080051715 *||Oct 25, 2007||Feb 28, 2008||Young Matthew E||Automatic injector with kickback attenuation|
|US20080097312 *||Apr 20, 2007||Apr 24, 2008||Wilmot John G||Autoinjector with needle depth adapter|
|US20080132838 *||Oct 31, 2007||Jun 5, 2008||Washington Biotech Corporation||Methods for injecting medicines to a desired depth|
|US20090270804 *||Oct 27, 2008||Oct 29, 2009||Meridian Medical Technologies, Inc.||Automatic injector with needle cover|
|US20090299278 *||May 2, 2007||Dec 3, 2009||Lesch Jr Paul R||Injector with adjustable dosing|
|US20100094217 *||Sep 29, 2009||Apr 15, 2010||Wyrick Ronald E||Methods Performed by Medicine Injection Apparatuses|
|US20100100039 *||Sep 29, 2009||Apr 22, 2010||Wyrick Ronald E||Medicine Injection Apparatuses|
|US20100121272 *||Jan 15, 2010||May 13, 2010||Owen Mumford Limted||Relating to injection devices|
|US20100137791 *||Dec 2, 2008||Jun 3, 2010||Sanofi-Aventis Deutschland Gmbh||Drive assembly suitable for use in a medication delivery device an medication delivery device|
|US20100292643 *||Jul 27, 2010||Nov 18, 2010||Meridian Medical Technologies, Inc.||Autoinjector With Needle Depth Adapter|
|US20100318037 *||Aug 17, 2010||Dec 16, 2010||Meridian Medical Technologies, Inc.||Automatic injector|
|US20110137247 *||Jan 28, 2011||Jun 9, 2011||Meridian Medical Technologies, Inc.||Automatic injector with needle cover|
|US20110213315 *||Sep 18, 2009||Sep 1, 2011||Becton, Dickinson And Company||Medical injector with slidable sleeve activation|
|US20110226646 *||Jan 24, 2011||Sep 22, 2011||Wyrick Ronald E||Kits Containing Medicine Injection Devices And Containers|
|US20120083745 *||Dec 1, 2009||Apr 5, 2012||Sanofi-Aventis Deutschland Gmbh||Drive assembly suitable for use in a medication delivery device and medication delivery device|
|US20120172814 *||May 28, 2010||Jul 5, 2012||Sanofi-Aventis Deutschland Gmbh||Resetting mechanism for a drug delivery device|
|US20120209210 *||Apr 24, 2012||Aug 16, 2012||Sanofi-Aventis Deutschland Gmbh||Resetting mechanism for a drug delivery device|
|US20120209211 *||Apr 24, 2012||Aug 16, 2012||Sanofi-Aventis Deutschland Gmbh||Resetting mechanism for a drug delivery device|
|US20120209212 *||Apr 24, 2012||Aug 16, 2012||Sanofi-Aventis Deutschland Gmbh||Resetting mechanism for a drug delivery device|
|US20150105733 *||Oct 10, 2013||Apr 16, 2015||Ann M. Gilchrist||Syringe-Assist Device and Method for Utilizing the Same|
|DE2721545A1 *||May 13, 1977||Nov 24, 1977||Philips Nv||Injektionsspritze|
|DE4037418A1 *||Nov 24, 1990||May 29, 1991||Glaxo Group Ltd||Zufuehrvorrichtung fuer fluessige medikamente|
|DE4037418C2 *||Nov 24, 1990||Jan 29, 1998||Glaxo Group Ltd||Zuführvorrichtung für flüssige Medikamente|
|EP0695554A2||Jul 27, 1995||Feb 7, 1996||Survival Technology, Inc.||Automatic injector|
|EP2424594A1 *||Apr 29, 2010||Mar 7, 2012||Abbott Biotechnology Ltd||Automatic injection device|
|EP2424594A4 *||Apr 29, 2010||Dec 24, 2014||Abbvie Biotechnology Ltd||Automatic injection device|
|WO1985002776A1 *||Dec 14, 1984||Jul 4, 1985||Survival Technology, Inc.||Dual mode automatic injector|
|WO1986001120A1 *||May 29, 1985||Feb 27, 1986||Survival Technology, Inc.||Injection method and apparatus with electrical blood absorbing stimulation|
|WO1991016094A1 *||Apr 10, 1991||Oct 31, 1991||Survival Technology, Inc.||Dispersion multi-chamber auto-injector|
|WO1992021395A1 *||May 27, 1992||Dec 10, 1992||Arnis, Inc.||Auto-retracting needle injector system|
|WO1999020327A2||Oct 19, 1998||Apr 29, 1999||I-Flow Corporation||Spring-actuated infusion syringe|
|International Classification||A61M5/20, A61M5/32|
|Cooperative Classification||A61M2005/206, A61M2005/2073, A61M5/2033, A61M5/32|
|European Classification||A61M5/20C, A61M5/32|
|Nov 29, 1993||AS||Assignment|
Owner name: SURVIVAL TECHNOLOGY INC., MARYLAND
Free format text: RELEASE BY SECURED PARTY;ASSIGNOR:ESTATE OF STANLEY J. SARNOFF C/O ROBERT E. HERZSTEIN SHEARMAN & STERLING;REEL/FRAME:006782/0360
Effective date: 19931109
|Sep 20, 1990||AS||Assignment|
Owner name: SURVIVAL TECHNOLOGY, INC., MARYLAND
Free format text: RELEASED BY SECURED PARTY;ASSIGNOR:FIRST PENNSYLVANIA BANK N.A.;REEL/FRAME:005456/0252
Effective date: 19900914
|Sep 20, 1990||AS17||Release by secured party|
Owner name: FIRST PENNSYLVANIA BANK N.A.
Owner name: SURVIVAL TECHNOLOGY, INC., 8101 GLENBROOK ROAD, BE
Effective date: 19900914
|Apr 3, 1989||AS||Assignment|
Owner name: FIRST PENNSYLVANIA BANK N.A.
Free format text: SECURITY INTEREST;ASSIGNOR:SURVIVAL TECHNOLOGY, INC., A DE CORP.;REEL/FRAME:005126/0187
Effective date: 19890323