|Publication number||US3890953 A|
|Publication date||Jun 24, 1975|
|Filing date||Apr 6, 1972|
|Priority date||Apr 6, 1971|
|Also published as||US3820534|
|Publication number||US 3890953 A, US 3890953A, US-A-3890953, US3890953 A, US3890953A|
|Inventors||Kraus Werner, Viehbach Hans-Dieter|
|Original Assignee||Kraus Werner|
|Export Citation||BiBTeX, EndNote, RefMan|
|Patent Citations (5), Referenced by (151), Classifications (22)|
|External Links: USPTO, USPTO Assignment, Espacenet|
United States Patent Kraus et al.
ELECTRICAL APPARATUS GENERATING A LOW FREQUENCY, ALTERNATING MAGNETIC FIELD FOR PROMOTING THE GROWTH OF BONE AND OTHER BODY TISSUES lnventors: Werner Kraus, Munich; Hans-Dieter Viehbach, Aisingerwies, both of Germany Assignee: Werner Kraus, Munich, Germany Filed: Apr. 6, 1972 Appl. No.: 241,727
Foreign Application Priority Data Apr. 6, 1971 Germany 2116869 US. Cl 128/15; 128/821; 128/419 F Int. Cl Afiln 1/42 Field of Search 128/1 R, 1.3, 1.5, 82.1,
References Cited UNITED STATES PATENTS Brown 128/15 Primary ExaminerWilliam E. Kamm Attorney, Agent, or F irm--Spencer & Kaye The growth or repair of fractured bones or the growth of other body tissues is promoted by means of a coil which is applied to produce a magnetic field at the site in which growth is to be encouraged. The coil is supplied with a low frequency alternating voltage below 50 Hz. A device is applied to the body or implanted in the body in order to concentrate the magnetic field produced by the coil.
ABSTRACT 5 Claims, 8 Drawing Figures PATENTED JUN 2 4 I975 SHEET I SHEET PATENTEDJUN'24' 1915 PATENTEDJUN 24 ms 3 SHEET Fig. 8
BACKGROUND OF INVENTION .1. Field to which Invention Relates The present'invention relates to an apparatus for promoting the growth of bone and other body tissues.
It is known that the shifting of an electrochemical equilibrium exisitng in a living organism can lead to a change in a mechanical state in the organism. Proceeses of this type are continuely taking place in muscle tissue. Furthermore the contraction and expansion of fibers of collagen, that is to say the connective tissue substance, has been observed to take place following a change in the concentration ofa salt solution surrounding the fibers.
One example of the reversability of this principle is offered by the piezoelectric behavior of bone: In this case electrical deformation potentials, which arise owing to mechanical loading of bone fiber, regulate the dynamic equilibrium between the free calcium and phosphate ions in the blood, on the one hand, and the bound calcium and phosphate ions in the crystal lattice of the hydroxyl apatite on the other.
The changes in state occurring are thus due to the disturbance of an existing mechanical-chemical equilibrium between free and bound ions. The restoration of the original electro-neutrality is determined by the speed of diffusion of the free ions and the statistical distribution in the vicinity of the bound ions.
2. The Prior Art g k In accordance with aprevious proposal the reunion of fractured bones was to be encouraged by alternating electric currents, which were produced by means of a .pick-up coil which was attached to a splint (induction splint) serving for holding the bone in place. The splint had electrodes which extended into the gap of the fracture and the like. V
In the case of. clinical application of induction splints" of the proposed type effects were observed which cannot be completely explained on the basis of the galvanic action of the induced currents. On the basis of the above-mention ed considerations the idea then arose that electro-dynamical occurrences and such occurrences are involved in the case of the abovedescribed mechanical-chemical changes in equilibrium must be accompaniedby corresponding magnetic fields and that it should. however, also be possible to produce corresponding chemical and physical reactions by the action of electromagnetic fields in biological sy tems. Experiements carried out along these lines, which were aimed at distinguishing the biological actions of the electric field and that of the magnetic field, proved this assumption to be correct. It was found in this respect that the application at certain times and at certain locations of electromagnetic fields led to growth of bone and other body tissues. As a consequence of the action of the magnetic field a formation of new vessels occurringas a' primary factor was detected.
SUMMARY OF INVENTION On the basis of discoveries one aim of the present invention is to provide an electricalapparatus for proniotirigthe growth of bone and other body tissues.
The present invention resides in an electrical apparatus for promoting the growth of bone and other body tissues comprising a generator for the supply of low frequency alternating current with a frequency below 150 Hz, a coil which can be connected with the output of the generator and whose shape is adapted to the shape of the body part in which the growth of tissue is to be promoted and to the structure of the tissue to be grown,
and a device which can be applied to the body part for concentration of the field produced by the coil on to the zone of the body in which the tissue is to be grown. The device which can be applied to the body part can if necessary be implanted in the body.
With the apparatus in accordance with the invention substantial successes in healing have already been obtained in practice. For example in the case of severe accident casualities involving fractures, the time for repair of the fracture was reduced to half the normal time required for healing. Furthermore, the healing of bed sores could be brought about or substantially accelerated.
LIST OF FIGURES OF DRAWINGS Further development of the invention are defined in the subclaims.
In what follows embodiments of the invention will be described with reference to the accompanying drawings in detail.
FIG. 1 is a diagrammatic representation of a generator and a field coil of an apparatus in accordance with one embodiment of the invention.
FIGS. 2 and 3 show in perspective other types of field coils for a device in accordance with the invention.
FIG. 4 is a sectional view of a fractured thigh bone with a marrow or Kuntscher nail or pin, which comprises a field-concentrating device in accordance with one embodiment of the invention.
FIG. 5 is a diagrammatic representation of an applied compression screw, which also comprises a fieldconcentrating device in accordance with theinvention.
FIG. 6 shows a splint with embedded or inserted magnetic cores for the purpose of field concentration.
FIG. 7 shows a device for field concentration which can be implanted.
FIG. 8 shows a Kiintscher nail or pin, which comprises a magnetic core serving both for field concentration and also the inductive production of a galvanic current in the bone region.
DESCRIPTION OF PREFERRED EMBODIMENTS The apparatus shown diagrammatically in FIG. 1 comprises a AC generator 10, which supplies low frequency AC at the output terminals 12. The frequency of the AC lies below 150 Hz, for instance between I and or Hz. It has been found particularly favorable to use a frequency range between 5 or 10 and 30 Hz, for example 25 Hz. The half cycles of the alternating current should have comparatively gently sloping leading and trailing flanks (rise and fall times of the half cycles being for example in the order of magnitude of a quarter to an eighth of the length of a cycle); the AC can thus be a sinusoidal current with a low non-linear distortion, for example less than 20 percent, or preferably less than 10 percent, or a triangular wave current.
The rise and decay times of the cycles can be in the order of one quarter to one eighth of the cycle.
It is also possible for the current to consist of sinusoidal or triangular pulses with alternating polarity, which alternate either individually or in pairs with pulse intervals. It is clearly important in all cases that the front and trailing flanks of the current pulses or AC half cycles should slope relatively slightly. The rise and fall times are preferably substantially greater than 5 ms (corresponding to a sinusoidal current of 50 Hz), and preferably at least approximately 8 to 10 ms, for example up to 80 ms.
On the AC signal it is possible to superimpose a DC component and/or an AC component with a higher frequency by means of a modulating device contained in the generator 10. The frequency of the component with the higher frequency can amount, for example, to three to 10 times the basic frequency of the AC signal. It is also possible for a DC component to be superimposed on the AC signal so that the latter is asymmetric with respect to the zero line.
The output terminals 12 of the generator 10 are connected with a field coil 14, which in the case of the embodiment shown comprises an insulated copper ribbon in the form of an U-shaped flat coil on a flexible flat ,core. The windings of the coil thus comprise two respective bends of l80between which long relatively adjacently running longitudinal parts lie, which are bent in a U-shape. The particular shape of the coil is selected for producing a magnetic field B, whose direction is adapted to the structure of the bone or other body tissue whose growth is to be promoted. If, for example, an extremity 16, as indicated in broken lines, for example a thigh with a fractured femur is to be treated, the magnetic field B preferably runs in the direction in which the thigh bone is loaded during normal use, and
' the function of the blood vessels is encouraged.
Preferably, however, it is not only the spatial orientation of the magnetic field which is adapted to the circumstances present in the living organism, but also the timing. In additon to'known spatial structures of bone and other body tissues, the timing of the effect is also of significance. The most important change with time of the mechanical influences acting on the substance of the organism from the inside follows the heart beat.
The rhythm and form of the spread of the pressure wave of the blood in the organism determine the metabolic events with their biochemical and biophysical reactions to a substantial extent. For this reason actuation and/or control of the generator 10, and thus of the electromagnetic fields produced, is provided for by the systolic pressure wave in the zone of application. This can be carried out in particular with a pulse pressure wave detector 18, which is applied adjacent to the treatment zone between the latter and the heart on the body part to be teated.
The actuating pulse produced at the pulse detecting device 18 in accordance with the systolic pressure wave can be used in a generator 10 for initiating an individ- ,en line loops.
the function corresponding to the systolic pulse pressure wave ofa healthy person with blood vessels which are still elastic, more particularly a young person.
FIG. 2 shows another embodiment of a field coil which can be used for the present device. The field coil in accordance with FIG. 2 consists of a number of flat coils 14a, the shape of whose windings is indicated in the case of the uppermost coil by solid lines 20. The flat coils 14a can comprise ferromagnetic laminations and are connected at the sides corresponding to bends in the windings in a hinged manner so that the field coil 14', consisting of the flat coils connected in parallel or in series, can be applied as desired about a body part in order to induce in the latter a magnetic field, whose direction is indicated by the double arrow B, the paths of fields of the individual coils being indicated by brok- The flat coils 14a can on the other hand be connected at the end faces 15 in a hinging manner with each other, if the field coil is required for treating the spinal column for example.
The field coil 14" in accordance with FIG. 3 corresponds in principle with the field coil in accordance with FIG. 2 with the exception that the coils 14b, which are connected together in a hinged manner, have a circular cross-section.
Instead of flat coils 14a or coils 1417 with a circular cross-section it is naturally also possible to use other suitable coil forms, for example coils with an elliptical cross-section. I
As a coil a cylindrical or solenoid coil 40" is to be used, as indicated in FIG. 4.
If desired the distribution of windings on the field coils can be uneven in order to obtain a field concentration. For example the winding density in the case of the coils l4, and 14" can increase from the outside in an inward direction or it is possible to connect additional narrower coils which can be slid on in order to achieve the desired field distribution.
The solenoid coil 14" in F IG; 4 has such a large internal diameter that it can he slid over an extremity to be treated, for example a thigh 22, for example when the healing of the fractured femur 24 is to be promoted. The bone 24 is pinned in a conventional manner with a Kiintscher nail 26 or pin, in whose interior a field concentrating device of a rod-shaped body 28 of ferromagnetic material with a high initial magnetic permeability and a low remanence is used, that is to say a magnetically soft" material. The body 28 is fixed by staples 30 in the desired position. It brings about a concentration of the magnetic field at the site of the fracture 32. The core is coated with an inert polytetrafluoroethylene layer. In a manner similar to the arrangement to be described with reference to FIG. 7, it is also possible to provide several cores with a spacing between them in the nail or pin and between the cores a relatively strong leak field occurs which promotes growth. This leak field extends into the gap in the fracture or the site of the fracture.
FIG. 5 shows a so-called compression screw 34, which is provided with an axial hole, in which a ferromagnetic body 36, serving for field concentration, is located. which preferably is also made of a magnetically soft material.
FIG. 6 shows a splint which 'canbe implanted or support plate as is conventional in principle for fixing fractured bones, with which it is connected by screw means. In the construction shown in FIG. 6 there is, however, the novel feature that it comprises embedded or inserted bodies 40 of ferromagnetic material in order to bring about a concentration of the magnetic field produced by the field coil adjacent to the fractured bone.
Since with the invention a comparatively rapid restoration of the bone and other body tissue can be achieved it is possible to make the splint 38 and other corresponding support structures (pins etc.) so as to be substantially lighter than has been the case to date. For example the splint 38 can be made of plastics material and can be used only for fixing the bone fracture parts, since the bone will be rapidly repaired to such an extent that it can carry the load itself.
Preferably such support structures are made of organic material, for example cut or milled from animal bone. This material, which must be freed of protein, may then possibly be absorbed by the living body, can then possibly be absorbed or taken up by the body, so that subsequent treatment is substantially simplified. The production of bone fracture support parts such as pins or nails, plates, half-shells and screws of bone substance or synthetically produced molded parts, which are treated with calcium and orthophosphates and can be taken up by the body, offers advantages not only with the present purpose.
FIG. 7 shows a further apparatus for producing a field concentration. It comprises a flexible tube 42 of an inert material such as polyethylene, in which rodshaped bodies 44 of a metnetically soft material with a high permeability are embedded. The flexible tube 42 can be shrunk after the insertion of the bodies in order to fix the bodies 44 with a spacing between them. The flexible tube with the bodies 44 can then be embedded in the tissue to be renegerated.
The position of the magnetic core 44, see FIG. 7, in the flexible tube 42 can also be fixed by means of distance pieces 43, such as pieces of polytetrafluoroethylene, which are arranged between the cores.
The marrow or Kiintscher nail 26' or pin shown in FIG. 8 comprises, as is the case with the nail 26 in accordance with FIG. 4, a magnetic core 28', which serves for field concentration at the site of fracture. Furthermore the core carries at least one winding 46, in which the low frequency magnetic field produces an alternating voltage. The ends of the winding are connected with bare platinum-iridium electrodes 48, which may be in the form of wires or metal sheet. The electrodes are arranged on an insulated section 50 of the outside of the nail or they can be embedded in an insulated manner in the outside of the nail. The alternating current flowing between the electrodes 48 through the fracture site also encourages the healing process and callus formation, as has already been proposed in connection with the splint.
Instead of using magnetically soft material, it is also possible to use a ferromagnetic material with a relatively low remanence, which is so selected that a certain premagnetisation can be set and this premagnetisation has superimposed on it the alternating magnetisation as produced by the field coil. The same effect can be achieved by superimposing a DC component on the AC supply to the field coil.
It is naturally possible for other coil and magnetic core arrangements to be used in order to concentrate the low frequency alternating magnetic field adjacent to the organism, in which the growth or regeneration of tissue is to be promoted. The direction of the magnetic field lines then preferably runs parallel to that of the fiber or vessel structure.
All parts coming into contact with the body substance consist of a physiologically compatible material, at least on their surface.
What is claimed is:
1. In an electrical apparatus for promoting the growth of bone and other body tissues by the application thereto of a low frequency alternating magnetic field, such apparatus having current generating means and field applicator means, the improvement wherein the applicator means comprises a flat solenoid coil having an axis about which the coil is wound and composed of a plurality of parallel and flexible windings, each said winding having two adjacent elongate portions and two coil bends joining said elongate por tions together, said coil being flexible in the coil plane in the region of said elongate portion for being bent into a U-shape, said coil being bent into such U-shape about an axis parallel to the coil axis and adapted for connection to a source of low frequency alternating current.
2. In an electrical apparatus for promoting the growth of bone and other body tissues by the application thereto of a low frequency alternating magnetic field, such apparatus having current generating means and field applicator means, the improvement wherein the applicator means comprises a U-shaped flat solenoid coil having an axis about which the coil is wound and composed of a plurality of parallel windings, each said winding having two adjacent, elongate U-shaped portions and two 180 coil bends joining the ends of said elongate portions together, the coil being curved in such U-shape about an axis parallel to the coil axis and adapted for connection to a source of low frequency alternating current.
3. In an electrical apparatus for promoting the growth of bone and other body tissues by the application thereto of a low frequency alternating magnetic field, such apparatus having current generating means and field applicator means, the improvement wherein the applicator means comprises: a plurality of solenoid coils each having an axis about which such coil is wound and disposed adjacent one another with their axes parallel and adapated for connection to a source of low frequency alternating current, and hinge means connecting adjacent coils together for pivotal movement about axes parallel to the axes of said coils.
4. An arrangement as defined in claim 3 wherein said coils having a cylindrical cross section.
5. An arrangement as defined in claim 3 wherein said coils have an elliptical cross section.
* l l l
|Cited Patent||Filing date||Publication date||Applicant||Title|
|US435343 *||May 29, 1890||Aug 26, 1890||Articulated electro-magnet|
|US717072 *||May 8, 1901||Dec 30, 1902||John Burry||Magnetotherapeutic apparatus.|
|US743373 *||Oct 2, 1903||Nov 3, 1903||Emile Bachelet||Electromagnetic therapeutic apparatus.|
|US2368207 *||Jan 30, 1941||Jan 30, 1945||Warren S Eaton||Method of and means for therapeutic treatment|
|US2404283 *||Jan 17, 1942||Jul 16, 1946||Licbel Flarsheim Company||Electrode for diathermy treatments|
|Citing Patent||Filing date||Publication date||Applicant||Title|
|US4056097 *||Mar 15, 1976||Nov 1, 1977||Joachim Adolf Maass||Contactless stimulus transducer|
|US4066065 *||May 24, 1976||Jan 3, 1978||Werner Kraus||Coil structure for electromagnetic therapy|
|US4105017 *||Nov 17, 1976||Aug 8, 1978||Electro-Biology, Inc.||Modification of the growth repair and maintenance behavior of living tissue and cells by a specific and selective change in electrical environment|
|US4142521 *||Dec 23, 1976||Mar 6, 1979||Hoffmann-La Roche Inc.||Electrostatic soft tissue wound repair enhancement|
|US4154246 *||Jul 25, 1977||May 15, 1979||Leveen Harry H||Field intensification in radio frequency thermotherapy|
|US4186729 *||Nov 25, 1977||Feb 5, 1980||Donald L. Morton & Associates||Deep heating electrode|
|US4266532 *||Mar 17, 1978||May 12, 1981||Electro-Biology, Inc.||Modification of the growth, repair and maintenance behavior of living tissues and cells by a specific and selective change in electrical environment|
|US4266533 *||Apr 9, 1979||May 12, 1981||Electro-Biology, Inc.||Modification of the growth, repair and maintenance behavior of living tissues and cells by a specific and selective change in electrical environment|
|US4306564 *||Sep 25, 1978||Dec 22, 1981||Werner Kraus||Electrification attachment for an osteo-synthesis implantate|
|US4315503 *||Dec 5, 1979||Feb 16, 1982||Electro-Biology, Inc.||Modification of the growth, repair and maintenance behavior of living tissues and cells by a specific and selective change in electrical environment|
|US4421115 *||Dec 8, 1980||Dec 20, 1983||Werner Kraus||Electrification attachment for an osteosynthesis implantate|
|US4506673 *||Oct 18, 1982||Mar 26, 1985||Rorer Group Inc.||Therapeutic treatment within joint capsules of the body|
|US4537181 *||Dec 5, 1978||Aug 27, 1985||Hydromagnetics, Inc.||Hydromagnetic apparatus for non-surgical in vivo removal of calcium deposits|
|US4549547 *||Jul 27, 1982||Oct 29, 1985||Trustees Of The University Of Pennsylvania||Implantable bone growth stimulator|
|US4561426 *||Sep 27, 1984||Dec 31, 1985||Stewart David J||Magnetic biological device|
|US4602638 *||Oct 3, 1984||Jul 29, 1986||Eddie Adams||Apparatus and method for invasive electrical stimulation of bone fractures|
|US4616629 *||May 24, 1985||Oct 14, 1986||Electro-Biology, Inc.||Coil construction for electromagnetic treatment of an afflicted body region|
|US4672951 *||Dec 30, 1985||Jun 16, 1987||Bio-Electric, Inc.||Method and apparatus for treatment of biological tissue|
|US4838850 *||May 7, 1987||Jun 13, 1989||Henning Rosengart||Electromedical treatment apparatus|
|US4865733 *||Mar 20, 1987||Sep 12, 1989||Toa Nenryo Kogyo K.K.||Cell separator device|
|US4889120 *||May 27, 1986||Dec 26, 1989||Gordon Robert T||Method for the connection of biological structures|
|US4915110 *||Jul 25, 1988||Apr 10, 1990||Theri-Teck, Inc.||Therapeutic electrostatic device|
|US4932951 *||Mar 23, 1988||Jun 12, 1990||Life Resonances, Inc.||Method and apparatus for controlling tissue growth and an applied fluctuating magnetic field|
|US5000178 *||Mar 18, 1988||Mar 19, 1991||Lti Biomedical, Inc.||Shielded electromagnetic transducer|
|US5052997 *||Apr 10, 1987||Oct 1, 1991||The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services||Diathermy coil|
|US5059298 *||Dec 1, 1988||Oct 22, 1991||Life Resonances, Inc.||Method and apparatus for regulating transmembrane ion movement|
|US5067940 *||Oct 31, 1988||Nov 26, 1991||Life Resonances, Inc.||Method and apparatus for controlling the growth of cartilage|
|US5077934 *||Sep 22, 1989||Jan 7, 1992||Life Resonances, Inc.||Method and apparatus for controlling plant growth|
|US5087336 *||Apr 25, 1989||Feb 11, 1992||Life Resonances, Inc.||Methods and apparatus for regulating transmembrane ion movement utilizing selective harmonic frequencies and simultaneous multiple ion regulation|
|US5099756 *||Jun 1, 1989||Mar 31, 1992||Harry H. Leveen||Radio frequency thermotherapy|
|US5100373 *||Jan 9, 1989||Mar 31, 1992||Life Resonances, Inc.||Techniques for controlling osteoporosis using non-invasive magnetic fields|
|US5103806 *||Jul 31, 1990||Apr 14, 1992||The Research Foundation Of State University Of New York||Method for the promotion of growth, ingrowth and healing of bone tissue and the prevention of osteopenia by mechanical loading of the bone tissue|
|US5106361 *||Oct 6, 1988||Apr 21, 1992||Life Resonances, Inc.||Method and apparatus for controlling the growth of non-osseous non-cartilaginous solid connective tissue|
|US5123898 *||Mar 20, 1990||Jun 23, 1992||Life Resonances, Inc.||Method and apparatus for controlling tissue growth with an applied fluctuating magnetic field|
|US5160591 *||Oct 25, 1991||Nov 3, 1992||Life Resonances, Inc.||Methods and apparatus for regulating transmembrane ion movement utilizing selective harmonic frequencies and simultaneous multiple ion regulation|
|US5195940 *||Jun 20, 1991||Mar 23, 1993||Iatromed, Inc.||Method for increased production of growth factor in living tissue using an applied fluctuating magnetic field|
|US5215642 *||Oct 16, 1991||Jun 1, 1993||Life Resonances, Inc.||Improved method and apparatus for regulating transmembrane ion movement|
|US5267939 *||Oct 10, 1991||Dec 7, 1993||Life Resonances, Inc.||Techniques for controlling osteoporosis using non-invasive magnetic fields|
|US5269745 *||Apr 1, 1992||Dec 14, 1993||Life Resonances, Inc.||Method and apparatus for controlling tissue growth with an applied fluctuating magnetic field|
|US5269746 *||Nov 6, 1992||Dec 14, 1993||Jacobson Jerry I||Therapeutic treatment of mammals for epilepsy and Parkinson's disease|
|US5290409 *||Aug 20, 1992||Mar 1, 1994||Life Resonances, Inc.||Methods and apparatus for regulating transmembrane ion movement utilizing selective harmonic frequencies and simultaneous multiple ion regulation|
|US5330410 *||Feb 8, 1993||Jul 19, 1994||Iatromed, Inc.||Method for increased production of growth factor in living tissue using an applied fluctuating magnetic field|
|US5366435 *||Dec 14, 1993||Nov 22, 1994||Jacobson Jerry I||Therapeutic treatment of mammals|
|US5441495 *||Oct 13, 1993||Aug 15, 1995||Life Resonances, Inc.||Electromagnetic treatment therapy for stroke victim|
|US5441527 *||Jan 24, 1994||Aug 15, 1995||Amei Technologies Inc.||Implantable bone growth stimulator and method of operation|
|US5524624 *||May 5, 1994||Jun 11, 1996||Amei Technologies Inc.||Apparatus and method for stimulating tissue growth with ultrasound|
|US5565005 *||Feb 17, 1993||Oct 15, 1996||Amei Technologies Inc.||Implantable growth tissue stimulator and method operation|
|US5766231 *||Oct 11, 1996||Jun 16, 1998||Neomedics, Inc.||Implantable growth tissue stimulator and method of operation|
|US5880661 *||Apr 1, 1996||Mar 9, 1999||Emf Therapeutics, Inc.||Complex magnetic field generating device|
|US5968527 *||Dec 4, 1997||Oct 19, 1999||Catholic University Of America, The||Protection of living systems from the adverse effects of stress|
|US6007476 *||Oct 22, 1997||Dec 28, 1999||Emf Therapeutics, Inc.||Non-particle, non-photonic device and method for affecting angiogenesis|
|US6083149 *||Jul 8, 1998||Jul 4, 2000||Emf Therapeutics, Inc.||Magnetic field device and method for inhibiting angiogenesis and retarding growth rates of tumors in mammals|
|US6099459 *||Sep 4, 1998||Aug 8, 2000||Jacobson; Jerry I.||Magnetic field generating device and method of generating and applying a magnetic field for treatment of specified conditions|
|US6149577 *||Mar 18, 1999||Nov 21, 2000||Emf Therapeutics, Inc.||Apparatus and method for creating a substantially contained, finite magnetic field useful for relieving the symptoms pain and discomfort associated with degenerative diseases and disorders in mammals|
|US6200259 *||Jun 3, 1999||Mar 13, 2001||Keith L. March||Method of treating cardiovascular disease by angiogenesis|
|US6290638||May 18, 1998||Sep 18, 2001||Luis E. Canedo||Electromagnetic method of treatment of epilepsy and apparatus therefor|
|US6334069||Jan 15, 1999||Dec 25, 2001||Regenesis Biomedical, Inc.||Pulsed electromagnetic energy treatment apparatus and method|
|US6353763||Jun 27, 2000||Mar 5, 2002||Regenesis Biomedical, Inc.||Pulsed electromagnetic energy treatment apparatus and method|
|US6358196 *||Dec 29, 1999||Mar 19, 2002||Reiza Rayman||Magnetic retraction system for laparoscopic surgery and method of use thereof|
|US6458071||Aug 31, 1999||Oct 1, 2002||Jerry I. Jacobson||Method for electromagnetically restructuring water for organismic consumption|
|US6463323||Nov 12, 1999||Oct 8, 2002||Em Vascular, Inc.||Electrically mediated angiogenesis|
|US6556872||Dec 5, 2000||Apr 29, 2003||Ev Vascular, Inc.||Therapeutic device and method for treating diseases of cardiac muscle|
|US6560489||Jan 8, 2001||May 6, 2003||Em Vascular, Inc.||Therapeutic device and method for treating diseases of cardiac muscle|
|US6620117||Jan 20, 2000||Sep 16, 2003||Connextech, L.L.C.||Vibrational device for stimulating tissue and organs|
|US6733435||Mar 8, 2002||May 11, 2004||Canedo Luis||Electromagnetic method of treatment of lesions associated with inadequate blood perfusion, partial denervation, tissue loss, pain, edema, inflammation and infection|
|US6843776||May 30, 2003||Jan 18, 2005||Juvent, Inc.||Apparatus and methods for therapeutically treating damaged tissues, bone fractures, osteopenia, or osteoporosis|
|US6884227||Nov 8, 2002||Apr 26, 2005||Juvent, Inc.||Apparatuses and methods for therapeutically treating damaged tissues, bone fractures, osteopenia, or osteoporosis|
|US6978173 *||Oct 31, 2001||Dec 20, 2005||Biotronik Mess- Und Therapiegeraete Gmbh & Co.||Device for influencing cell-growth mechanisms in vessels of a human or animal body|
|US7024239||Nov 20, 2001||Apr 4, 2006||Regenesis Biomedical, Inc.||Pulsed electromagnetic energy treatment apparatus and method|
|US7094211||Mar 7, 2005||Aug 22, 2006||Krompasick Donald E||Apparatuses and methods for therapeutically treating damaged tissues, bone fractures, osteopenia, or osteoporosis|
|US7186209||Oct 9, 2003||Mar 6, 2007||Jacobson Jerry I||Cardioelectromagnetic treatment|
|US7207954||Jan 10, 2005||Apr 24, 2007||Juvent, Inc.||Apparatus and methods for therapeutically treating damaged tissues, bone fractures, osteopenia, or osteoporosis|
|US7207955||Jun 7, 2006||Apr 24, 2007||Juvent, Inc.||Apparatus and method for therapeutically treating damaged tissues, bone fractures, osteopenia or osteoporosis|
|US7410469||May 18, 2000||Aug 12, 2008||Exogen, Inc.||Apparatus and method for ultrasonically and electromagnetically treating tissue|
|US7429248||Aug 9, 2001||Sep 30, 2008||Exogen, Inc.||Method and apparatus for controlling acoustic modes in tissue healing applications|
|US7429249||Jun 14, 2000||Sep 30, 2008||Exogen, Inc.||Method for cavitation-induced tissue healing with low intensity ultrasound|
|US7628764||Aug 13, 2001||Dec 8, 2009||Exogen, Inc.||Ultrasonic treatment for wounds|
|US7648498 *||Feb 21, 2006||Jan 19, 2010||Siemens Aktiengesellschaft||Irradiation device for influencing a biological structure in a subject with electromagnetic radiation|
|US7789841||Apr 24, 2002||Sep 7, 2010||Exogen, Inc.||Method and apparatus for connective tissue treatment|
|US7896797 *||Apr 14, 2008||Mar 1, 2011||Ivivi Health Sciences, Llc||Electromagnetic field treatment apparatus and method for using same|
|US7985191||Apr 24, 2007||Jul 26, 2011||American Medical Innovations, L.L.C.||Apparatus and methods for therapeutically treating damaged tissues, bone fractures, osteopenia, or osteoporosis|
|US8043290||Sep 29, 2004||Oct 25, 2011||The Regents Of The University Of California, San Francisco||Apparatus and methods for magnetic alteration of deformities|
|US8114036||Mar 16, 2007||Feb 14, 2012||American Medical Innovations, L.L.C.||Apparatus and method for therapeutically treating damaged tissues, bone fractures, osteopenia or osteoporosis|
|US8123707||Jun 18, 2010||Feb 28, 2012||Exogen, Inc.||Method and apparatus for connective tissue treatment|
|US8142454||Aug 11, 2008||Mar 27, 2012||The Regents Of The University Of California, San Francisco||Apparatus and method for magnetic alteration of anatomical features|
|US8343027||Jan 30, 2012||Jan 1, 2013||Ivivi Health Sciences, Llc||Methods and devices for providing electromagnetic treatment in the presence of a metal-containing implant|
|US8415123||Mar 15, 2010||Apr 9, 2013||Ivivi Health Sciences, Llc||Electromagnetic treatment apparatus and method for angiogenesis modulation of living tissues and cells|
|US8439915||Feb 22, 2007||May 14, 2013||The Regents Of The University Of California||Apparatus and methods for magnetic alteration of anatomical features|
|US8491509||Mar 24, 2006||Jul 23, 2013||Titi Trandafir||Apparatus and method for monitoring and controlling the transmissibility of mechanical vibration energy during dynamic motion therapy|
|US8603017||Jul 18, 2006||Dec 10, 2013||American Medical Innovations, L.L.C.||Vibrational therapy assembly for treating and preventing the onset of deep venous thrombosis|
|US8613695||Jul 9, 2009||Dec 24, 2013||Applied Magnetics, Llc||Highly precise and low level signal-generating drivers, systems, and methods of use|
|US8615293||Feb 27, 2007||Dec 24, 2013||Jacobson Resonance Enterprises, Inc.||Cardioelectromagnetic treatment|
|US8672826 *||Apr 4, 2007||Mar 18, 2014||Global Energy Medicine Pty. Ltd.||Vivo stimulation of cellular material|
|US8795210||Jul 10, 2007||Aug 5, 2014||American Medical Innovations, L.L.C.||System and method for a low profile vibrating plate|
|US8961385||Apr 5, 2011||Feb 24, 2015||Ivivi Health Sciences, Llc||Devices and method for treatment of degenerative joint diseases with electromagnetic fields|
|US9320913||Apr 16, 2015||Apr 26, 2016||Rio Grande Neurosciences, Inc.||Two-part pulsed electromagnetic field applicator for application of therapeutic energy|
|US9415233||Feb 3, 2014||Aug 16, 2016||Rio Grande Neurosciences, Inc.||Apparatus and method for electromagnetic treatment of neurological pain|
|US9427598||Oct 3, 2011||Aug 30, 2016||Rio Grande Neurosciences, Inc.||Method and apparatus for electromagnetic treatment of head, cerebral and neural injury in animals and humans|
|US9433797||Feb 3, 2014||Sep 6, 2016||Rio Grande Neurosciences, Inc.||Apparatus and method for electromagnetic treatment of neurodegenerative conditions|
|US9440089||Feb 3, 2014||Sep 13, 2016||Rio Grande Neurosciences, Inc.||Apparatus and method for electromagnetic treatment of neurological injury or condition caused by a stroke|
|US9457198 *||Feb 18, 2009||Oct 4, 2016||Shenzhen Cornley Hi-Tech Co., Ltd.||Ultra-low frequency magnetic stimulating device and operational method thereof|
|US9480854||Nov 14, 2013||Nov 1, 2016||Applied Magnetics, Llc||Highly precise and low level signal-generating drivers, systems, and methods of use|
|US20020040233 *||Nov 20, 2001||Apr 4, 2002||George Frank R.||Pulsed electromagnetic energy treatment apparatus and method|
|US20020138100 *||Oct 31, 2001||Sep 26, 2002||Biotronik Mess-Und Therapiegeraete Gmbh & Co.||Device for influencing cell-growth mechanisms in vessels of a human or animal body|
|US20040092848 *||May 30, 2003||May 13, 2004||Titi Trandafir|
|US20040092849 *||Nov 8, 2002||May 13, 2004||Talish Roger J.||Apparatuses and methods for therapeutically treating damaged tissues, bone fractures, osteopenia, or osteoporosis|
|US20050059153 *||Jan 16, 2004||Mar 17, 2005||George Frank R.||Electromagnetic activation of gene expression and cell growth|
|US20050148911 *||Mar 7, 2005||Jul 7, 2005||Exogen Inc.||Apparatuses and methods for therapeuticaly treating damaged tissues, bone fractures, osteopenia or osteoporosis|
|US20050154334 *||Jan 10, 2005||Jul 14, 2005||Titi Trandafir|
|US20060034943 *||Oct 11, 2005||Feb 16, 2006||Technology Innovations Llc||Process for treating a biological organism|
|US20060074448 *||Sep 29, 2004||Apr 6, 2006||The Regents Of The University Of California||Apparatus and methods for magnetic alteration of deformities|
|US20060079897 *||Sep 7, 2005||Apr 13, 2006||Harrison Michael R||Apparatus and methods for magnetic alteration of anatomical features|
|US20060129189 *||Jan 30, 2006||Jun 15, 2006||Regenesis Biomedical, Inc.||Pulsed electromagnetic energy treatment apparatus and method|
|US20060206108 *||Feb 21, 2006||Sep 14, 2006||Eckhard Hempel||Irradiation device for influencing a biological structure in a subject with electromagnetic radiation|
|US20060217640 *||Mar 24, 2006||Sep 28, 2006||Titi Trandafir||Apparatus and method for monitoring and controlling the transmissibility of mechanical vibration energy during dynamic motion therapy|
|US20060229536 *||Jun 7, 2006||Oct 12, 2006||Exogen, Inc.||Apparatus and method for therapeutically treating damaged tissues, bone fractures, osteopenia or osteoporosis|
|US20060271107 *||May 9, 2006||Nov 30, 2006||Harrison Michael R||Apparatus and methods for magnetic alteration of anatomical features|
|US20060276845 *||Aug 11, 2006||Dec 7, 2006||Regenesis Biomedical, Inc.||Pulsed electromagnetic energy treatment apparatus and method|
|US20070021693 *||Jul 14, 2006||Jan 25, 2007||Titi Trandafir||Dynamic motion therapy apparatus having a treatment feedback indicator|
|US20070038165 *||Jul 18, 2006||Feb 15, 2007||Juvent Inc.||Vibrational therapy assembly for treating and preventing the onset of deep venous thrombosis|
|US20070043310 *||Jul 14, 2006||Feb 22, 2007||Juvent Inc.||Method and apparatus for monitoring patient compliance during dynamic motion therapy|
|US20070055096 *||Jul 31, 2006||Mar 8, 2007||Berry Cheryl J||Sexual stimulation devices and toys with features for playing audio and/or video received from an external source|
|US20070055185 *||Jul 17, 2006||Mar 8, 2007||Juvent Inc.||Dynamic motion therapy apparatus having a treatment feedback indicator|
|US20070213179 *||Mar 8, 2007||Sep 13, 2007||Juvent, Inc.||Mechanical loading apparatus having a signal modulating assembly|
|US20070225626 *||Mar 16, 2007||Sep 27, 2007||Krompasick Donald E|
|US20070260161 *||Apr 24, 2007||Nov 8, 2007||Titi Trandafir|
|US20070276378 *||Feb 22, 2007||Nov 29, 2007||The Regents Of The University Of California||Apparatus and methods for magnetic alteration of anatomical features|
|US20070276440 *||Feb 27, 2007||Nov 29, 2007||Jacobson Jerry I||Cardioelectromagnetic treatment|
|US20080009776 *||Apr 27, 2007||Jan 10, 2008||Juvent Inc.||Apparatus and method for monitoring and controlling the transmissibility of mechanical vibration energy during dynamic motion therapy|
|US20080139979 *||Dec 4, 2007||Jun 12, 2008||Juvent, Inc.||Vibrational therapy assembly adapted for removably mounting to a bed|
|US20080140155 *||Oct 22, 2007||Jun 12, 2008||Pilla Arthur A||Excessive fibrous capsule formation and capsular contracture apparatus and method for using same|
|US20090048618 *||Aug 11, 2008||Feb 19, 2009||The Regents Of The University Of California||Apparatus and method for magnetic alteration of anatomical features|
|US20090069626 *||Apr 14, 2008||Mar 12, 2009||Pilla Arthur A||Electromagnetic field treatment apparatus and method for using same|
|US20100057655 *||Aug 24, 2009||Mar 4, 2010||Jacobson Jerry I||Systems And Methods For Providing A Magnetic Resonance Treatment To A Subject|
|US20100092916 *||Sep 9, 2009||Apr 15, 2010||New York University||Method and devices to increase craniofacial bone density|
|US20100114103 *||Nov 6, 2008||May 6, 2010||The Regents Of The University Of California||Apparatus and methods for alteration of anatomical features|
|US20100160713 *||Jul 18, 2008||Jun 24, 2010||Qisc B.V.||Device and method for electromagnetic stimulation of a process within living organisms|
|US20100197992 *||Jul 17, 2008||Aug 5, 2010||Qisc B.V.||Coil structure for electromagnetic stimulation of a process within a living organism, device using such coil structure and method of driving|
|US20100210893 *||Apr 30, 2010||Aug 19, 2010||Pilla Arthur A||Apparatus and method for electromagnetic treatment of plant, animal, and human tissue, organs, cells, and molecules|
|US20100222631 *||Apr 30, 2010||Sep 2, 2010||Pilla Arthur A||Apparatus and method for electromagnetic treatment of plant, animal, and human tissue, organs, cells, and molecules|
|US20100261947 *||Apr 4, 2007||Oct 14, 2010||Global Energy Medicine Pty Ltd||Vivo stimulation of cellular material|
|US20110015698 *||Sep 24, 2010||Jan 20, 2011||Regenesis Biomedical, Inc.||Pulsed electromagnetic energy treatment apparatus and method|
|US20110112352 *||Jun 21, 2010||May 12, 2011||Pilla Arthur A||Apparatus and method for electromagnetic treatment|
|US20110207989 *||Apr 5, 2011||Aug 25, 2011||Pilla Arthur A||Devices and method for treatment of degenerative joint diseases with electromagnetic fields|
|US20110301402 *||Feb 18, 2009||Dec 8, 2011||Meizhou Cornley Hi-Tech Co., Ltd.||Ultra-low frequency magnetic stimulating device and operational method thereof|
|US20140046115 *||Oct 21, 2013||Feb 13, 2014||Arthur A. Pilla||Apparatus and method for electromagnetic treatment of plant, animal, and human tissue, organs, cells, and molecules|
|EP0181053A2 *||May 28, 1985||May 14, 1986||Irt, Inc.||Pulse electro-magnetic field therapy device with auto biased circuit and method for use|
|EP0181053A3 *||May 28, 1985||Jul 20, 1988||Irt, Inc.||Pulse electro-magnetic field therapy device with auto biased circuit and method for use|
|WO1992019317A1 *||May 6, 1992||Nov 12, 1992||Richard Markoll||Treatment of the musculoskeletal system|
|WO1995031939A1||May 25, 1995||Nov 30, 1995||Jacobson Jerry I||Method and apparatus for ameliorating aging process|
|WO2004043324A1||Oct 30, 2003||May 27, 2004||Exogen, Inc.|
|U.S. Classification||600/14, 600/12, 602/2|
|International Classification||A61B17/58, A61N2/00, A61N1/05, A61N1/40, A61F2/28, A61N1/32, A61B17/56, A61N2/04, A61F2/30, A61N2/02|
|Cooperative Classification||A61B17/58, A61N2/02, A61F2/30, A61N1/40, A61F2002/2821|
|European Classification||A61B17/58, A61F2/30, A61N1/40, A61N2/02|