|Publication number||US3906550 A|
|Publication date||Sep 23, 1975|
|Filing date||Dec 27, 1973|
|Priority date||Dec 27, 1973|
|Publication number||US 3906550 A, US 3906550A, US-A-3906550, US3906550 A, US3906550A|
|Inventors||Galante Jorge, Rostoker William|
|Original Assignee||Galante Jorge, Rostoker William|
|Export Citation||BiBTeX, EndNote, RefMan|
|Patent Citations (3), Referenced by (228), Classifications (30) |
|External Links: USPTO, USPTO Assignment, Espacenet|
Prosthetic device having a porous fiber metal structure
US 3906550 A
Prosthetic devices for replacement, attachment and reconstruction of bone structure in the skeletal systems of humans and animals. The prosthetic devices may be a fiber metal structure of sufficient section to support loads adequately or may include a solid load carrying member having a fiber metal structure secured to the surface thereof. The fiber metal structure is sintered and open-pored so that the bone and tissue into which the prosthetic device is implanted will grow into such fiber metal structure.
United States Patent [191 Rostoker et al.
1 PROSTHETIC DEVICE HAVING A POROUS FIBER METAL STRUCTURE  Inventors: William Rostoker, 2052 W. 108th Pl., Chicago, 111. 60643; Jorge Galante, One Brighton Ln., Oakbrook, 111. 60521  Filed: Dec. 27, 1973  Appl. No.: 428,763
 U.S. Cl. 3/1.912; 3/1913; 3/19; 128/92 C; 128/92 BC; 32/10 A; 29/419  Int. Cl. A61F 1/24; A61C 13/30  Field of Search 3/1, 1.9-1.913; 128/92 C, 92 CA, 92 BC, 92 R; 32/10 A  References Cited UNlTED STATES PATENTS 3,127,668 4/1964 Troy 128/92 C UX 3,685,058 8/1972 Tronzo 3/1 3,790,507 2/1974 Hodosh 1. 128/92 C X FOREIGN PATENTS OR APPLICATIONS 1,042,834 11/1958 Germany 128/92C OTHER PUBLICATIONS Sintered Fiber Metal Composites as a Basis for At- 1 1 Sept. 23, 1975 tachment of Implants to Bone," by J. Galante et al., The Journal ofBone and Joint Surgery, V01. 53-A, No. 1, January 1971, pp. 101-1 14, Mar. 1.
Primary Examiner-Ronald L. Frinks Attorney, Agent, or FirmAlbert Siegel 57 ABSTRACT Prosthetic devices for replacement, attachment and reconstruction of bone structure in the skeletal systems of humans and animals. The prosthetic devices may be a fiber metal structure of sufficient section to support loads adequately or may include a solid load carrying member having a fiber metal structure secured to the surface thereof. The fiber metal structure is sintered and open-pored so that the bone and tissue into which the prosthetic device is implanted will grow into such fiber metal structure.
To provide the proper interlock between fibers, the individual fiber strands are prekinked prior to cutting into the desired length. The kink pattern should be substantially sinusoidal. Preferably such kink pattern should have an amplitude (H) to period (W) relationship, H/W of 0.24 or greater.
10 Claims, 6 Drawing Figures mas-Kmart, was;
US atfint P 3,1975 Sheet 1 of 2 3%};
l 12 STRAIN PERCENT CON-FRACTION FIG 2 x vv O O O O O m m 8 6 A 2 H O m 363! mmw m mzmmwmniou 2 Mn 2 2 E,
2 til IE1 H Pamm Sept. 23,1975 Sheet 2 of2 3 96 5 DEVICE HAVING A POROUS FIBER PROSTHETIC v j METAL STRUCTURE There is reserved to the government of theiUnited State'sof America a non-exclusive, irrevocable and Toyalty-free license to make and use ,-and' to sell asiprovided by law, embodiments of the invention. as hereinafter described and'claims, with the power to sublicense for all governmental purposes.
BACKGROUND OF T INVENTION v This invention relates toprosthctic devices for .re-
placement, reconstruction and attachment in the skele- There are four principal methods by which the device can be attached to the bone. These methods include:
(1). lmpaction of the prosthetic stem into. the medallary cavity of the bone; (2). Mechanical internalfixation, e.g., screws; (3). Methyl methacrylatepolymerizing in situ used as a cement or. filler between the prosthesis and the bone and (4,). Porous materials into which the bone can grow. Each of these methods presents problems that can cause .failure of theprosthetic implant. V I
The devices which are impacted into the medullary cavity are held in place by a compressive residualstress interaction which may be more commonly-referredto as a force fit. lf this stress interaction is relaxed in the surrounding bone, due to physicalor biological processes, the attachment is lost and the device becomes loose, thereby requiring surgical removal and refitting of the prosthesis. I v I Mechanical internal fixation produces acceptable limited term attachments.. However, in long term use the device may become loose and thereby require replacement. I
Polymethyl methacrylate has also produced acceptable limited term attachments. Howebver, doubtsstill exist as to the overall safety of itsuse from a biological point of view partly from damage to surrounding tissue from monomer and heat interaction, and partly thatthe plastics may age in the body fluid thereby becoming brittle and tending to crack or erumblei An open -pore material into which bone could grow should provide ideal skeletal fixation. Numerous materials and processes for producing porous aggregates have been disclosed which serve-this purpose. For example, see US. Pat. No. 3,314,420. Typically these aggregates are powder metalsor powder ceramics which are compressed and sintered to propufeep porous but relatively strong body. In order to obtain'the high level of porosity and acceptable green strength; rather fine powders are required, 'the use ofiwhichg'substantially limits the size of theip ores During sintering much of the porosity ceases to become interconnecting and thus a high proportion of the pores at the surface become isolated .from the interior of the body. This'isolfation limits bone ingrowth and results. in lals ituation similar to the roughened surface of a solid Furthermore, the mechanical propertiesflof si nteredpojwders are not'ideal; for example/porous consolidated"ceramiesf are very weak and brittle, .and;,cracks propagate *quickly throughout the whole body of the porous aggregate at low stresses or with small -.impact-energies. Consolidated metal powders with p orosities in the range of 4060% void, are stronger than the consolidated ceramics but still are've'ry brittleand have poor toughness. Moreover, sinte red me tal powders are susceptible to fatigue failure Both sintered ceramics and metal powders have compliances which more closely approx.- imate the pore free material. Compliance is defined as .the change in elasticstrain per unit change in stress.
The subject invention provides aprosthetic device which is non-toxic, compatible and not subject to loosening or movement after implantation, and furtherineludes the provision of an open-pore attachment for bone ingrowth which attachment is highly compliant, not brittle, resistant to crack propagation and has a broad range of readily controllable pore sizes.
SUMMARY OFYTHE INVENTION .There is provided by thisinvention a prosthetic device including a porous aggregate produced by molding and sintering short metal fibers. The sintering process creates metallurgical bonds at the points of contact of the fibers. Thus, the fiber metal aggregate has considerable mechanical strength due to mechanical interlock of the fibers and the sintered bonds.
The degree of mechanical interlock and mechanical strength of the porous aggregate. is appreciably improved if the wire is kinked prior to being cutinto the short metal fibers. The kinking pattern should be sinusoidal. Preferably,,the ratio of amplitude and period of the sine wave should be 0.24 or greater. After the kinking is formed, the wire is cut into the desired lengths.
By using fiber metals the range of pore .sizes can be readily controlled and the attachment is not subject to the crack propagation and low strength problems associated with ceramics or powdered metal attachments.
tachment is not subject to the aging problems or reac tion problems of the plastics of the prior art. Since the pore size can; be readily controlled by the pressing and forming parameters, the density of the sintered composite can approximate the density of the bone to which the prosthetic device is implanted.
'BRlEF DESCRlPTlQN OF THE DRAWINGS Referring to the drawingsin .which the same characters of reference are employed to indicate correspondemplary hip oint prosthes1s;
ing, similar parts throughout the several figures of the FIG. 1 isa vertical sectional view illustrating an ex- .FlG. Z is a stress-strain diagram for a moldedand sintered Co Cr.-W, alloy fiberaggregate;
FIG, 3 illustrates a sinusoidal kinking. pattern of a molded fiber, metal structure;
FIG. 5 is a vertical sectional view depicting a femur having a bone segment reconstruction prosthesis; and FIG. 6 is a vertical view of a mountingfor a dental prosthesis.
DESCRIPTION OF THE PREFERRED EMBODIMENT Referring now to FIG. 1 of the drawings, the reference numeral 10 indicates generally a hip joint prosthesis which is exemplary of the prosthetic devices embodying the principles of the subject invention. The joint prosthesis 10 comprises two individual prosthesis. a femur prosthesis l2 and a acetabulum prosthesis 14. The femur prosthesis 12 comprises a load carrying means 16 of solid construction and a sintered fiber metal attachment structure indicated generally by the reference numeral 18.
The solid load carrying means 16 includes a ball carried on a flange 22, which in turn is mounted to a rod 24 having a cup-shaped bottom end member 26. The fiber metal attachment structure 18 includes a plurality' of tubular fiber metal segments 28a, 28b, 28c. 28d. and 2st I The rod 24 and segments 281! through 280 are inserted into the medullary cavity of the femur which is appropriately reamed and is thus fixed in place so that the ball 20 is properly orientated with respect to the hip socket 32. As the healing process takes place. the bone which is adjacent the fiber metal segments 280 through 280 grows into the attachment 18. It has been observed that after the bone ingrowth has proceeded to a substantial degree. a secure fixation is produced between the ingrown bone and the fiber metal implant.
The attachment segments 281: through 280 can be secured to the rod 24 in a number of ways. The most effective way is to metallurgically bond the fibers contacting the surface of the rod thereto; however. it will be appreciated that the flange 22 and end member 26 when tightened also act to hold the attachment segments 28 in place. Other methods by which the segments 28 are mounted to the rod 24, include cementing or the like or meehnical fixation; however. as indicated above metallurgical attachment is preferred.
The solid load carrying rod 24 or a similar member is normally used when tension and bending loads may be anticipated. However. where only compressive loads are experienced. the fiber metal structure 18 may be used without such rod 24. However, in some situations where stresses and strains are realized. a fiber metal structure of substantial area may be used without the rod 24.
The acetabulum prosthesis 14 includes fiber metal attachment component 34 and a solid wear insert 36. The fiber metal attachment is molded into the proper shape and then fitted into a cavity formed in the acetabulum during surgery. Bone ingrowth'will hold the fiber component 34 rigidly in place. Since a fiber metal surface is probably not particularly wear resistant. the wear insert 36 is molded integral with the fiber component 34. Furthermore. the insert 36 not subject to bone ingrowth can be held in place mechanically so that it can be subsequently removed and replaced if necessary.
In another prosthetic system. a union may be accomplished between the upper and lower portions 38 and 40 ofa severed femur 30 generally as shown in FIG. 5.
As is seen, the severance space 41 is filled with a cylindrical sintered fiber metal member 42 having a center core hole 44 through which a sintered fiber-sleeved shaft 46 is passed. to provide fixation to the extremities of the femur 30. The shaft 46'ineludes a solid center member 48, sintered fiber metal sleeves 50a, 50b, 50c, 50! and 50c, and end members 52 and 54. Shaft 46 is fitted into the medullary cavity 56 of the femur 30 which is appropriately reamed.
In still another prosthetic application, a device 58, as shown in FIG. 6, may be implanted in the jawbones 60 of humans or animals as a basis for mounting artificial teeth or dentures. The dental prosthesis 58 comprises a monolithic sintered fiber metal member 62, and a solid center shaft 64 passing centrally through the fiber member 62. Shaft 64 includes a flanged bottom 65. When bone or tissue grows into the fiber member 62, the upper end of the shaft 40 is securely held in place and an artificial tooth 66 can then be mounted thereon. The ingrowth of gingival tissue provides a bacterial seal.
The fiber metal segments 28, and the fiber metal attachment component 34 shown in FIG. 1, and the fiber metal member 42 and sleeves 50 shown in FIG. 5, and the fiber metal member 62 shown in FIG. 6 are all porous aggregates produced by molding and sintering short metal fibers. The points of contact between fibers become metallurgical bonded during sintering. Thus, the fiber metal aggregate has considerable mechanical strength due to the sintered bonds and the mechanical interlocks.
Short lengths of fine wire such as stainless steel, unalloyed titanium or Co-Cr-W alloy. are mechanically molded into the desired precise shapes using constraining dies and moving punches. When loading the wire charge of short metal fibers in the die during molding, the long axes thereof, should be on the most part coaxial with the punch motion. Upon applying the proper pressure with the dies and punches. at threedimensional mechanically interlocked network of fibers is formed.
The degree of interlock and unsintered or green strength of a pressing with the dies. is substantially increased if the original wire is prekinked prior to cutting the wire into the short fibers. The desired kinking can be accomplished by passing the wire through a set of meshing gears.
It has been found that the wire should be prekinked into a sinusoidal pattern to provide the greatest mechanical interlock. as shown in FIG. 3. Thereafter, the kinked sinusoidal wire is cut into the desired short fiber lengths.
To provide the optimum interlock the kink pattern should have an amplitude (H) to period relationship (W). H/W of 0.24 or greater.
The kinked short fiber strands of 316 L stainless steel; unalloyed titanium and Co-Cr-W'alloy wire. are molded into the precise shape for the fiber metal aggregate as aforestated. using constraining dies and moving punches. The choice of the wire size and the density of the fiber strands loaded in the dies will govern the final parameter dimensions of the fiber metal aggregate.
The molding operation is followed by a sintering stage in which points of contact become actual metallurgical bonds. Adequate bonding has been obtained with oven temperatures within the range of [070 I240 C for approximately 2 hours.
Repressing, using the same die and punch tooling, of the sintered metal fiber aggregate must be done to enable the aggregate to be formed into precise and reprodueible dimensions which are necessary for good clinical responses.
The sintered fiber metal aggregates shown in FIGS. 1, 5 and 6 may be molded having void or a porosity of 40 to 50 percent per unit area. A porosity of 60% could also be achieved, but the green strength is generally too fragile, and therefore, could effect the dimensional control because of elastic recovery. Also fiber metal aggregate having such greater porosities are not sufficiently firm at the edges and tend to crumble.
Wire sizes as fine as 0.013 centimeters in diameter and as coarse as 0.030 centimeters in diameter have been satisfactorily molded. In the molded and sintered fiber metal aggregate, the metal fibers are completely interconnected. The pore shapes as may be seen from FIG. 4, which is a magnification of a portion of a sintered-molded fiber metal aggregate, cannot be deb scribed in any simple geometric shape. The largest .prineipal dimension of the pores is approximately equal to the wire diameter when the void content is about 50 percent. However, pressing or molding to higher densities would lead to more constricted pore sizes.
Wire is cut to lengths ranging from 1.3 to 3.8 centimeters. The longer the wire, the more difficult it is to feed into dies. On the other hand, long wire lengths give more interlock and better molded strengths.
Turning now to FIG. 2, a graphical representation of a reversible (elastic) stress strain cycle is shown for Co- Cr-W alloy wire of 0.023 centimeters in diameter, molded to 50 percent porosity and sintered at 1240 C for 3 hours. Before testing and obtaining the data for FIG. 2, the sintered specimen was recompressed to a 7% reduction in height.
The elastic properties of Co-Cr-W alloy and other metal of the same class, such as stainless steel and titanium have elastic properties more like an elastomer than a metal. A sintered specimen shows a purely plastic strain range of about 3-10 percent on the application of very small loads. Thereafter, there is an elastic strain range of about 3 percent in which the modulus is a continuous function of strain (FIG. 2). For the strain range of about 1 percent, the modulus is about 10"kg/cm2 for the sintered fiber metal structure.
The sintered porous fiber metal structure disclosed herein has an elastic modulus substantially less than the elastic modulus for porous metals produced by sintered powders. This enables the sintered porous fiber metal structure to be an effective interface between bone tissue and a load-bearing prosthesis; and it further provides a very high compliance (large strains per unit applied stress), which is a safeguard against high localized stresses at the prothesis-tissue interface.
By repressing procedures the external dimensions of prostheses may be precisely regulated to the excavation so that a zero clearance fit exists. The zero clearance fit is vital to the clinical success of fixation by bone and soft tissue. In the absence of a zero clearance fit, the
prothesis is isolated by fibrous or non-functional tissue. For a tooth root prosthesis this leads to loosening. Other porous materials cannot easily be sized to precise dimensions.
The foregoing specification and description are intended as illustrative of the invention, the scope of which is defined in the following claims.
1. A prosthetic device for incorporation into the skeletal structure of a human or animal including:
a porous fiber metal structure formed from a plurality of substantially, sinusoidally shaped fiber strands, each of said fibers having a ratio of amplitude to period of substantially 0.24 or greater, said strands being metallurgically bonded to each other at their points of contact, said fiber metal structure providing at least a portion of the surface of said prosthetic device adjacent said skeletal structure to enable bone and soft tissue growth into said metal structure, said period being substantially the length of a cycle of said sinusoidal fiber strand and said amplitude being substantially the height/2 between a positive peak and a negative peak of said sinusoi dal fiber strand.
2. The prosthetic device of claim 1, wherein said fiber metal structure is between 10% and porous.
3. The prosthetic device of claim 1, wherein the diameter of said fiber strands is between about 0.013 centimeters and 0.030 centimeters.
4. The prosthetic device of claim I, wherein the length of said fiber strands is between about 1.3 centimeter and 3.8 centimeters.
5. The prosthetic device of claim 1 includes a noncompressible rod, said fiber metal structure being sccured to the outside of said rod.
6. The prosthetic device of claim 1, wherein said fiber metal structure is selected from the group consisting of titanium, Co-CrW altoy, stainless steel, tantalum and zirconium.
7. The prosthetic device of claim 1, includes:
a wear resistant member, said fiber metal structure being mounted on said wear member, said fiber metal structure adapted to be in contact with said skeletal structure when. implanted therein.
8. The prosthetic device of claim 5, wherein said fiber metal structure comprises a plurality of cylindrical segments mounted on and surrounding said rod.
9. The prosthetic device of claim 8 further includes:
a second porous fiber metal structure having a bore therein, said bore being dimensioned to receive said rod with said segments thereon.
10. The prosthetic device of claim I wherein said device is a dental prosthesis. including an upstanding mounting member mounted in said fiber metal structure and extending outward therefrom, said fiber metal structure extending around said upstanding member for operatively contacting the jaw bone to receive the growth of said jaw bone and gingival soft tissue.
=l =l l
|Cited Patent||Filing date||Publication date||Applicant||Title|
|US3127668 *||Mar 3, 1955||Apr 7, 1964||Iit Res Inst||High strength-variable porosity sintered metal fiber articles and method of making the same|
|US3685058 *||Oct 19, 1970||Aug 22, 1972||Raymond G Tronzo||Hip prosthesis|
|US3790507 *||Jul 6, 1970||Feb 5, 1974||Research Corp||Plastic bone composition|
|Citing Patent||Filing date||Publication date||Applicant||Title|
|US4038703 *||Nov 14, 1975||Aug 2, 1977||General Atomic Company||Prosthetic devices having a region of controlled porosity|
|US4156943 *||Aug 24, 1977||Jun 5, 1979||Collier John P||High-strength porous prosthetic device and process for making the same|
|US4186486 *||Nov 4, 1977||Feb 5, 1980||Maurice Gordon||Dental prosthesis|
|US4259072 *||Jul 25, 1979||Mar 31, 1981||Kyoto Ceramic Co., Ltd.||Ceramic endosseous implant|
|US4292695 *||Jun 25, 1980||Oct 6, 1981||Lord Corporation||Prosthesis stem|
|US4439152 *||Mar 4, 1982||Mar 27, 1984||Small Irwin A||Method of jawbone abutment implant for dental prostheses and implant device|
|US4446579 *||Apr 16, 1982||May 8, 1984||Kyocera Corporation||Flexible ceramic bio-implant member|
|US4479271 *||Oct 26, 1981||Oct 30, 1984||Zimmer, Inc.||Tibial component for a knee joint prosthesis|
|US4488319 *||Oct 26, 1981||Dec 18, 1984||Clemson University||Method of two-stage implantation of a joint prosthesis and prosthetic product|
|US4492577 *||Oct 25, 1982||Jan 8, 1985||Farris Edward T||Surgical implants with solid interiors and porous surfaces|
|US4535485 *||Mar 12, 1982||Aug 20, 1985||Medical Biological Sciences, Inc.||Polymeric acrylic prothesis|
|US4536158 *||Sep 30, 1982||Aug 20, 1985||Medical Biological Sciences, Inc.||Oral prosthesis and method for producing same|
|US4536894 *||Aug 4, 1983||Aug 27, 1985||Galante Jorge O||Hip prosthesis with flared porous bony ingrowth pads|
|US4546501 *||Sep 28, 1982||Oct 15, 1985||Gustilo Ramon B||Hip prosthesis|
|US4547327 *||Aug 8, 1984||Oct 15, 1985||Medical Biological Sciences, Inc.||Method for producing a porous prosthesis|
|US4608055 *||Jan 12, 1984||Aug 26, 1986||Mayo Foundation||Femoral component for hip prosthesis|
|US4693721 *||Apr 22, 1986||Sep 15, 1987||Paul Ducheyne||Porous flexible metal fiber material for surgical implantation|
|US4704686 *||May 20, 1986||Nov 3, 1987||Aldinger Guenther||Method of manufacturing of individually formed prothesis or implant|
|US4778474 *||Jul 22, 1985||Oct 18, 1988||Homsy Charles A||Acetabular prosthesis|
|US4813963 *||Aug 24, 1987||Mar 21, 1989||Zimmer, Inc.||Femoral component for a hip prosthesis|
|US4829152 *||Nov 16, 1987||May 9, 1989||Rostoker, Inc.||Method of resistance welding a porous body to a substrate|
|US4842517 *||Sep 30, 1987||Jun 27, 1989||Haruyuki Kawahara||Endosseous implant having mesh pore structure|
|US4851007 *||Mar 18, 1988||Jul 25, 1989||Gray Frank B||Femoral component for a hip prosthesis|
|US4865609 *||Mar 2, 1988||Sep 12, 1989||Bioconcepts, Inc.||Modular joint prosthesis assembly and method of removing|
|US4888023 *||Jan 19, 1988||Dec 19, 1989||Osteonics Corp.||Femoral prosthesis with uncoupled distal tip|
|US4919665 *||Jan 23, 1989||Apr 24, 1990||Homsy Charles A||Implantation of articulating joint prosthesis|
|US4944764 *||Jun 13, 1988||Jul 31, 1990||Headcorn Instrumentation Ltd.||Hip prosthesis|
|US4976738 *||Dec 2, 1985||Dec 11, 1990||Sulzer Brothers Limited||Porous metal overlay for an implant surface|
|US4978355 *||Jan 6, 1986||Dec 18, 1990||Sulzer Brothers Limited||Plastic bone implant having a reinforced contact surface|
|US4978358 *||Jun 21, 1989||Dec 18, 1990||Zimmer Inc.||Orthopaedic prosthetic device possessing improved composite stem design|
|US4986834 *||Mar 30, 1990||Jan 22, 1991||Boehringer Mannheim Corporation||Load sharing femoral hip implant|
|US4994085 *||Mar 8, 1989||Feb 19, 1991||Aisin Seiki Kabushiki Kaisha||Artificial stem unit for coxa with setting guide|
|US4997444 *||Dec 28, 1989||Mar 5, 1991||Zimmer, Inc.||Implant having varying modulus of elasticity|
|US4997445 *||Dec 8, 1989||Mar 5, 1991||Zimmer, Inc.||Metal-backed prosthetic implant with enhanced bonding of polyethylene portion to metal base|
|US5002580 *||Oct 7, 1988||Mar 26, 1991||Pfizer Hospital Products Group, Inc.||Prosthetic device and method of implantation|
|US5004476 *||Oct 31, 1989||Apr 2, 1991||Tulane University||Porous coated total hip replacement system|
|US5013324 *||Nov 28, 1988||May 7, 1991||Zimmer, Inc.||Prosthetic implant with wrapped porous surface|
|US5018285 *||Jan 16, 1990||May 28, 1991||Zimmer, Inc.||Method of constructing prosthetic implant with wrapped porous surface|
|US5030233 *||Jul 17, 1987||Jul 9, 1991||Paul Ducheyne||Porous flexible metal fiber material for surgical implantation|
|US5032129 *||Nov 18, 1986||Jul 16, 1991||Technische Hochschule Karl-Marx-Stadt||Bone and tissue growth|
|US5062854 *||Jul 24, 1990||Nov 5, 1991||Pfizer Hospital Products Group||Prosthetic device and method of implantation|
|US5078746 *||Jan 25, 1989||Jan 7, 1992||Richards Medical Company||Femoral stem distal centralizer|
|US5080674 *||Sep 20, 1990||Jan 14, 1992||Zimmer, Inc.||Attachment mechanism for securing an additional portion to an implant|
|US5108435 *||Dec 19, 1990||Apr 28, 1992||Pfizer Hospital Products Group, Inc.||Cast bone ingrowth surface|
|US5108449 *||Dec 31, 1990||Apr 28, 1992||Gray Frank B||Femoral component for a hip prosthesis|
|US5147408 *||Jun 19, 1991||Sep 15, 1992||Pfizer Hospital Products Group, Inc.||Prosthetic device and method of implantation|
|US5167502 *||Jun 18, 1991||Dec 1, 1992||Haruyuki Kawahara||Method for an endosseous implant having mesh pore structure|
|US5198308 *||Dec 21, 1990||Mar 30, 1993||Zimmer, Inc.||Titanium porous surface bonded to a cobalt-based alloy substrate in an orthopaedic implant device|
|US5201767 *||Jul 15, 1991||Apr 13, 1993||Johnson & Johnson Orthopaedics, Inc.||Fluted-wedge osteal prosthetic component|
|US5222561 *||Oct 9, 1992||Jun 29, 1993||Rostoker, Inc.||Shoes and pads for horses|
|US5323954 *||Nov 30, 1992||Jun 28, 1994||Zimmer, Inc.||Method of bonding titanium to a cobalt-based alloy substrate in an orthophedic implant device|
|US5336267 *||Jan 26, 1993||Aug 9, 1994||Kubein Meesenburg Dietmar||Artificial joint|
|US5342366 *||Feb 19, 1992||Aug 30, 1994||Biomet, Inc.||Surgical instruments for hip revision|
|US5360452 *||Dec 6, 1993||Nov 1, 1994||Depuy Inc.||Enhanced fixation system for a prosthetic implant|
|US5383938 *||Nov 29, 1993||Jan 24, 1995||Zimmer, Inc.||Locking ring for an acetabular cup|
|US5387243 *||Nov 23, 1992||Feb 7, 1995||Zimmer, Inc.||Method for converting a cementable implant to a press fit implant|
|US5489306 *||Jan 3, 1995||Feb 6, 1996||Gorski; Jerrold M.||Graduated porosity implant for fibro-osseous integration|
|US5492768 *||Apr 21, 1995||Feb 20, 1996||Kyocera Corporation||Titanium fiber in the form of a net; used in medical field, for example, orthopedic, neurological and oral surgery and dental; transplant|
|US5496375 *||Sep 14, 1994||Mar 5, 1996||Zimmer, Inc.||Prosthetic implant with circumferential porous pad having interlocking tabs|
|US5545227 *||Jun 20, 1994||Aug 13, 1996||Smith & Nephew Richards, Inc.||Biocompatible low modulus medical implants|
|US5556432 *||Feb 9, 1993||Sep 17, 1996||Joachim Theusner||Endoprosthesis for the human knee joint|
|US5562730 *||Jun 6, 1995||Oct 8, 1996||Smith & Nephew Richards, Inc.||Total artificial heart device of enhanced hemocompatibility|
|US5571198 *||Jan 21, 1994||Nov 5, 1996||David A. Drucker||Acetabular shell with selectively available bone screw holds|
|US5571628 *||Jul 23, 1993||Nov 5, 1996||Ribbon Technology Corporation||Metal fiber preforms and method for making the same|
|US5573401 *||Jun 16, 1994||Nov 12, 1996||Smith & Nephew Richards, Inc.||Biocompatible, low modulus dental devices|
|US5593444 *||Jun 27, 1994||Jan 14, 1997||Nobelpharma Ab||Spacing member for attaching cranial facial prosthesis|
|US5665119 *||May 31, 1994||Sep 9, 1997||Sulzer Medizinaltechnik Ag||Titanium wire knit into fabric and shaped|
|US5674280 *||Oct 12, 1995||Oct 7, 1997||Smith & Nephew, Inc.||Nontoxic prostheses for implanting in living body; wear, friction, corrosion resistance|
|US5676632 *||Jun 6, 1995||Oct 14, 1997||Smith & Nephew Richards, Inc.||Fabricated from metal alloy comprising titanium and niobium|
|US5683442 *||Nov 8, 1996||Nov 4, 1997||Smith & Nephew, Inc.||Cardiovascular implants of enhanced biocompatibility|
|US5685306 *||Jun 6, 1995||Nov 11, 1997||Smith & Nephew, Inc.||Flexible, biocompatible, metal alloy catheter|
|US5690670 *||Jun 6, 1995||Nov 25, 1997||Davidson; James A.||Stents of enhanced biocompatibility and hemocompatibility|
|US5697932 *||Nov 9, 1994||Dec 16, 1997||Osteonics Corp.||Bone graft delivery system and method|
|US5713901 *||Mar 9, 1994||Feb 3, 1998||Tock; Gideon Raphael||Reticulated orthopaedic element to exploit the medullary canal of the long bones|
|US5713947 *||Jun 6, 1995||Feb 3, 1998||Smith & Nephew, Inc.||Cardiovascular implants of enhanced biocompatibility|
|US5716400 *||Jun 6, 1995||Feb 10, 1998||Smith & Nephew, Inc.||Alloy of titanium, niobium and zirconium having enhanced hemocompatability|
|US5733284 *||Jul 15, 1994||Mar 31, 1998||Paulette Fairant||Device for anchoring spinal instrumentation on a vertebra|
|US5885299 *||Mar 14, 1996||Mar 23, 1999||Surgical Dynamics, Inc.||Apparatus and method for implant insertion|
|US5906616 *||Jan 15, 1997||May 25, 1999||Surgical Dynamics, Inc.||Conically shaped anterior fusion cage and method of implantation|
|US5925077 *||Apr 2, 1997||Jul 20, 1999||Biomet, Inc.||Apparatus and method for plugging holes in an acetabular shell component|
|US5945153 *||Jul 29, 1997||Aug 31, 1999||Southwest Research Institute||Non-irritating antimicrobial coating for medical implants and a process for preparing same|
|US5961554 *||Dec 31, 1996||Oct 5, 1999||Janson; Frank S||Titanium or alloy|
|US5961555 *||Mar 17, 1998||Oct 5, 1999||Huebner; Randall J.||Modular shoulder prosthesis|
|US5984905 *||Mar 18, 1997||Nov 16, 1999||Southwest Research Institute||Non-irritating antimicrobial coating for medical implants and a process for preparing same|
|US5986169 *||Dec 31, 1997||Nov 16, 1999||Biorthex Inc.||Porous nickel-titanium alloy article|
|US6015437 *||Apr 20, 1998||Jan 18, 2000||Headcorn Instrumentation Ltd.||Shoulder prosthesis|
|US6045555 *||Dec 10, 1997||Apr 4, 2000||Osteonics Corp.||Bone graft delivery system and method|
|US6077076 *||Jan 22, 1999||Jun 20, 2000||Comfort Biomedical, Inc.||Bone augmentation for prosthetic implants and the like|
|US6102953 *||Nov 13, 1998||Aug 15, 2000||Acumed, Inc.||Shoulder prosthesis|
|US6139520 *||Aug 28, 1997||Oct 31, 2000||Boston Scientific Corporation||System for implanting a cross-linked polysaccharide fiber and methods of forming and inserting the fiber|
|US6142998 *||Jan 3, 2000||Nov 7, 2000||Howmedica Osteonics Corp.||Bone graft delivery surgical instruments|
|US6143036 *||Jan 22, 1999||Nov 7, 2000||Comfort Biomedical, Inc.||Bone augmentation for prosthetic implants and the like|
|US6156070 *||Mar 26, 1999||Dec 5, 2000||Howmedica Osteonics Corp.||Allograft prosthetic joints and method|
|US6168627||Jan 18, 2000||Jan 2, 2001||Acumed, Inc.||Shoulder prosthesis|
|US6168628||Jan 18, 2000||Jan 2, 2001||Acumed, Inc.||Shoulder Prosthesis|
|US6193758||Oct 2, 1998||Feb 27, 2001||Acumed, Inc.||Shoulder prosthesis|
|US6214049||Jan 14, 1999||Apr 10, 2001||Comfort Biomedical, Inc.||Method and apparatus for augmentating osteointegration of prosthetic implant devices|
|US6296632||Aug 16, 1995||Oct 2, 2001||Boston Scientific Corporation||Ball-shaped fiber implant, and method and device for inserting the implant|
|US6299590||Jan 6, 1999||Oct 9, 2001||Boston Scientific Corporation||Implant, and method and device for inserting the implant|
|US6309395||Apr 25, 2000||Oct 30, 2001||Howmedica Osteonics Corp.||Bone graft delivery surgical instruments|
|US6312467||Sep 2, 1998||Nov 6, 2001||Iowa State University Research Foundation, Inc.||Method of restructuring bone|
|US6361567||Nov 12, 1999||Mar 26, 2002||Southwest Research Institute||Non-irritating antimicrobial coating for medical implants and a process for preparing same|
|US6364909||Aug 24, 1999||Apr 2, 2002||Iowa State University Research Foundation, Inc.||Method of restructuring bone|
|US6461385||Aug 30, 2000||Oct 8, 2002||Comfort Biomedical Inc.||Method and apparatus for augmenting osteointegration of prosthetic implant devices|
|US6494913||Feb 18, 2000||Dec 17, 2002||Acumed, Inc.||Shoulder prosthesis|
|US6572654||Oct 4, 2000||Jun 3, 2003||Albert N. Santilli||Intervertebral spacer|
|US6589199||Mar 29, 2000||Jul 8, 2003||Boston Scientific Corporation||System for implanting a cross-linked polysaccharide fiber and methods of forming and inserting the fiber|
|US6629947||Jun 11, 1999||Oct 7, 2003||Boston Scientific Corporation||Systems and methods for delivering flowable substances for use as implants and surgical sealants|
|US6673075||Dec 3, 2001||Jan 6, 2004||Albert N. Santilli||Porous intervertebral spacer|
|US6719793||Mar 25, 2002||Apr 13, 2004||Iowa State University Research Foundation, Inc.||Method of restructuring bone|
|US6866683||Dec 13, 2002||Mar 15, 2005||Medicine Lodge, Inc.||Modular implant for joint reconstruction and method of use|
|US6875239||Apr 25, 2002||Apr 5, 2005||Medicinelodge, Inc.||Modular prosthesis for replacing bone and method|
|US6887276||Dec 13, 2002||May 3, 2005||Medicine Lodge, Inc||Modular implant for joint reconstruction and method of use|
|US6902583||Apr 25, 2002||Jun 7, 2005||Medicinelodge, Inc.||Tripartite attachment mechanism and method for a modular prosthesis|
|US6913623 *||Aug 15, 2000||Jul 5, 2005||Centerpulse Orthopedics, Inc.||Two piecefused femoral hip stem|
|US6923810 *||Jun 7, 1995||Aug 2, 2005||Gary Karlin Michelson||Frusto-conical interbody spinal fusion implants|
|US6945448 *||Jun 6, 2003||Sep 20, 2005||Zimmer Technology, Inc.||Method for attaching a porous metal layer to a metal substrate|
|US6955677||Oct 15, 2002||Oct 18, 2005||The University Of North Carolina At Chapel Hill||Multi-angular fastening apparatus and method for surgical bone screw/plate systems|
|US7001371 *||Oct 3, 2000||Feb 21, 2006||Med Usa||Porous drug delivery system|
|US7235290||Jun 12, 2002||Jun 26, 2007||Stick Tech Oy||can be durably and firmly bonded to synthetic or living materials and used for medical and dental as well as technical applications|
|US7291149||Oct 4, 1999||Nov 6, 2007||Warsaw Orthopedic, Inc.||Method for inserting interbody spinal fusion implants|
|US7297163||Dec 16, 2002||Nov 20, 2007||Acumed Llc||Shoulder prosthesis|
|US7531004||Oct 26, 2004||May 12, 2009||Orthovita, Inc.||Comprising a homogenous composite of biocompatible, resorbable bovine collagen and calcium phosphate that at least partially surrounds a biocompatible mesh, the biocompatible bone graft having macro-, meso-, and microporosity|
|US7537618||Nov 13, 2006||May 26, 2009||Howmedica Osteonics Corp.||Modular humeral head|
|US7544208||May 2, 2005||Jun 9, 2009||Theken Spine, Llc||Adjustable corpectomy apparatus|
|US7597715||Feb 17, 2006||Oct 6, 2009||Biomet Manufacturing Corp.||Method and apparatus for use of porous implants|
|US7608105||Jul 20, 2005||Oct 27, 2009||Howmedica Osteonics Corp.||Methods of inserting conically-shaped fusion cages|
|US7635447||Feb 17, 2006||Dec 22, 2009||Biomet Manufacturing Corp.||removing the spacing agent by melting or sublimation a moldings which contains the mixture of metal/alloy powder and a spacing agent ammonium bicarbonate, to form a plurality of pores; promotes soft and hard tissue ingrowth|
|US7655162 *||Mar 2, 2006||Feb 2, 2010||Biomet Manufacturing Corp.||plasma spraying working surface (mandreal) with mixture of Al2o3 and TiO2 and/or Ti, as thickness builds up, the relative amount of aluminum oxide is decreased such that the composition is all Ti and TiO2, after desired thickness, the acetabular shell is extracted from mandreal; hip implant|
|US7691148||Mar 19, 2005||Apr 6, 2010||Warsaw Orthopedic, Inc.||Frusto-conical spinal implant|
|US7785370||Apr 10, 2009||Aug 31, 2010||Howmedica Osteonics Corp.||Modular humeral head|
|US7785371||Apr 10, 2009||Aug 31, 2010||Howmedica Osteonics Corp.||Modular humeral head|
|US7815645||Jan 14, 2005||Oct 19, 2010||Hudson Surgical Design, Inc.||Methods and apparatus for pinplasty bone resection|
|US7857814||Mar 8, 2005||Dec 28, 2010||Hudson Surgical Design, Inc.||Methods and apparatus for minimally invasive arthroplasty|
|US7857858||Jan 19, 2007||Dec 28, 2010||Zimmer Technology, Inc.||Modular bone implant, tool, and method|
|US7918382||Apr 18, 2005||Apr 5, 2011||Zimmer Technology, Inc.||Method for attaching a porous metal layer to a metal substrate|
|US7918876||Mar 24, 2004||Apr 5, 2011||Theken Spine, Llc||Spinal implant adjustment device|
|US7918892||Nov 19, 2007||Apr 5, 2011||Acumed Llc||Shoulder prosthesis|
|US7935151||Apr 9, 2010||May 3, 2011||Hudson Surgical Design, Inc.||Femoral prosthetic implant|
|US7942933||Apr 3, 2010||May 17, 2011||Warsaw Orthopedic, Inc.||Frusto-conical spinal implant|
|US7967822||Oct 29, 2004||Jun 28, 2011||Hudson Surgical Design, Inc.||Methods and apparatus for orthopedic implants|
|US8021368||Mar 8, 2005||Sep 20, 2011||Hudson Surgical Design, Inc.||Methods and apparatus for improved cutting tools for resection|
|US8021432||Oct 11, 2006||Sep 20, 2011||Biomet Manufacturing Corp.||Apparatus for use of porous implants|
|US8029573||Dec 7, 2006||Oct 4, 2011||Ihip Surgical, Llc||Method and apparatus for total hip replacement|
|US8062377||Oct 31, 2007||Nov 22, 2011||Hudson Surgical Design, Inc.||Methods and apparatus for knee arthroplasty|
|US8066778||Feb 22, 2007||Nov 29, 2011||Biomet Manufacturing Corp.||Porous metal cup with cobalt bearing surface|
|US8075312||Aug 30, 2006||Dec 13, 2011||Zimmer Dental, Inc.||Dental implant with improved osseointegration features|
|US8088167||Dec 15, 2009||Jan 3, 2012||Hudson Surgical Design, Inc.||Femoral prosthetic implant|
|US8105367||Jun 15, 2009||Jan 31, 2012||Smith & Nephew, Inc.||Bone plate and bone plate assemblies including polyaxial fasteners|
|US8110005||Feb 11, 2011||Feb 7, 2012||Biomet Manufacturing Corp.||Modular prosthesis and use thereof for replacing a radial head|
|US8114083||Mar 8, 2005||Feb 14, 2012||Hudson Surgical Design, Inc.||Methods and apparatus for improved drilling and milling tools for resection|
|US8114163||Nov 29, 2004||Feb 14, 2012||Biomet Manufacturing Corp.||Method and apparatus for adjusting height and angle for a radial head|
|US8123814||Jun 26, 2007||Feb 28, 2012||Biomet Manufacturing Corp.||Method and appartus for acetabular reconstruction|
|US8142510||Mar 17, 2008||Mar 27, 2012||Depuy Products, Inc.||Mobile bearing assembly having a non-planar interface|
|US8147557||Mar 30, 2007||Apr 3, 2012||Depuy Products, Inc.||Mobile bearing insert having offset dwell point|
|US8147558||Mar 17, 2008||Apr 3, 2012||Depuy Products, Inc.||Mobile bearing assembly having multiple articulation interfaces|
|US8191760||Feb 15, 2011||Jun 5, 2012||Zimmer Technology, Inc.||Method for attaching porous metal layer to a metal substrate|
|US8197550||Sep 14, 2009||Jun 12, 2012||Biomet Manufacturing Corp.||Method and apparatus for use of porous implants|
|US8211183||Mar 16, 2011||Jul 3, 2012||Ihip Surgical, Llc||Methods and systems for total hip replacement|
|US8231387||Jul 2, 2008||Jul 31, 2012||Zimmer, Inc.||Porous implant with non-porous threads|
|US8241367||Nov 22, 2010||Aug 14, 2012||Zimmer, Inc.||Modular bone implant, tool, and method|
|US8266780||Feb 27, 2008||Sep 18, 2012||Biomet Manufacturing Corp.||Method and apparatus for use of porous implants|
|US8287545||Mar 8, 2005||Oct 16, 2012||Hudson Surgical Design, Inc.||Methods and apparatus for enhanced retention of prosthetic implants|
|US8292967||Dec 5, 2005||Oct 23, 2012||Biomet Manufacturing Corp.||Method and apparatus for use of porous implants|
|US8298238||Aug 6, 2008||Oct 30, 2012||Hudson Surgical Design, Inc.||Methods and apparatus for pivotable guide surfaces for arthroplasty|
|US8328874||Mar 17, 2008||Dec 11, 2012||Depuy Products, Inc.||Mobile bearing assembly|
|US8329202||Dec 22, 2004||Dec 11, 2012||Depuy Products, Inc.||System and method for attaching soft tissue to an implant|
|US8353914||Jul 9, 2007||Jan 15, 2013||Hudson Surgical Design, Inc.||Methods and apparatus for improved profile based resection|
|US8353966 *||Jan 15, 2009||Jan 15, 2013||The Curators Of The University Of Missouri||Scaffold for bone and tissue repair in mammals|
|US8366781||Jun 30, 2010||Feb 5, 2013||Biomet Manufacturing Corp.||Modular prosthesis and use thereof for replacing a radial head|
|US8382807||Feb 8, 2008||Feb 26, 2013||Smith & Nephew, Inc.||Systems and methods for using polyaxial plates|
|US8399008||Aug 20, 2009||Mar 19, 2013||Purdue Research Foundation||System and method for attaching soft tissue to annodized metal implant|
|US8409292||May 17, 2011||Apr 2, 2013||Warsaw Orthopedic, Inc.||Spinal fusion implant|
|US8425615||Oct 13, 2009||Apr 23, 2013||Biomet Manufacturing Corp.||Method and apparatus for adjusting height and angle for a radial head|
|US8430932||Dec 6, 2011||Apr 30, 2013||Puget Bio Ventures LLC||Femoral prosthetic implant|
|US8468673||Sep 9, 2011||Jun 25, 2013||Bio2 Technologies, Inc.||Method of fabricating a porous orthopedic implant|
|US8506642 *||Apr 24, 2006||Aug 13, 2013||Philip Scott Lyren||Hip implant with porous body|
|US8535382||Dec 13, 2011||Sep 17, 2013||Biomet Manufacturing, Llc||Modular radial head prostheses|
|US8535385 *||Aug 8, 2011||Sep 17, 2013||Zimmer, Inc.||Prosthetic implant support structure|
|US8551181||Feb 27, 2012||Oct 8, 2013||Biomet Manufacturing, Llc||Method and apparatus for acetabular reconstruction|
|US8562346||Jul 2, 2008||Oct 22, 2013||Zimmer Dental, Inc.||Dental implant for a jaw with reduced bone volume and improved osseointegration features|
|US8562348||Jul 2, 2008||Oct 22, 2013||Zimmer Dental, Inc.||Modular implant with secured porous portion|
|US8579985||Dec 22, 2011||Nov 12, 2013||Ihip Surgical, Llc||Method and apparatus for hip replacement|
|US8585770||Jul 12, 2011||Nov 19, 2013||Biomet Manufacturing, Llc||Implant sleeve for cement hip stems|
|US8602782||Nov 24, 2009||Dec 10, 2013||Zimmer Dental, Inc.||Porous implant device with improved core|
|US8603095||Nov 8, 2011||Dec 10, 2013||Puget Bio Ventures LLC||Apparatuses for femoral and tibial resection|
|US8652183||Jul 7, 2010||Feb 18, 2014||Mari S Truman||Multi-angle orthopedic expansion head fastener|
|US8684734||Aug 10, 2012||Apr 1, 2014||Philip Scott Lyren||Dental implant with porous body|
|US8727203||Sep 16, 2010||May 20, 2014||Howmedica Osteonics Corp.||Methods for manufacturing porous orthopaedic implants|
|US8728168||Nov 15, 2010||May 20, 2014||Zimmer, Inc.||Prosthetic implant support structure|
|US8740906||Jul 11, 2008||Jun 3, 2014||Hudson Surgical Design, Inc.||Method and apparatus for wireplasty bone resection|
|US8764841||Mar 17, 2008||Jul 1, 2014||DePuy Synthes Products, LLC||Mobile bearing assembly having a closed track|
|US8795381||May 14, 2012||Aug 5, 2014||Ihip Surgical, Llc||Methods and systems for hip replacement|
|US8814567 *||Aug 30, 2007||Aug 26, 2014||Zimmer Dental, Inc.||Dental implant prosthetic device with improved osseointegration and esthetic features|
|US8851891||Dec 8, 2011||Oct 7, 2014||Zimmer Dental, Inc.||Expandable bone implant|
|US8888824||Feb 22, 2013||Nov 18, 2014||Smith & Nephew, Inc.||Systems and methods for using polyaxial plates|
|US8899981||Aug 27, 2013||Dec 2, 2014||Zimmer Dental, Inc.||Dental implant for a jaw with reduced bone volume and improved osseointegration features|
|US8899982||Jul 2, 2008||Dec 2, 2014||Zimmer Dental, Inc.||Implant with structure for securing a porous portion|
|US8920509||Jun 4, 2010||Dec 30, 2014||Biomet Manufacturing, Llc||Modular radial head prosthesis|
|US20060058882 *||Mar 8, 2005||Mar 16, 2006||Haines Timothy G||Methods and apparatus for conformable prosthetic implants|
|US20060276906 *||Feb 14, 2006||Dec 7, 2006||Hoag Stephen H||Fully porous prosthetic hip stem|
|US20110208189 *||Mar 10, 2011||Aug 25, 2011||Tecres S.P.A.||Disposable device for treatment of infections of human limbs|
|US20110295382 *||Aug 8, 2011||Dec 1, 2011||Zimmer, Inc.||Prosthetic implant support structure|
|US20120116455 *||Dec 22, 2011||May 10, 2012||Polaris Biotechnology, Inc.||Craniospinal fusion method and apparatus|
|US20120156646 *||Dec 21, 2010||Jun 21, 2012||Zimmer Dental, Inc.||Implant with porous sleeve including anti-rotation features|
|US20120183429 *||Jul 22, 2011||Jul 19, 2012||Bio2 Technologies, Inc.||Devices and Methods for Tissue Engineering|
|US20130013081 *||Sep 14, 2012||Jan 10, 2013||Astra Tech Ab||Nanosurface|
|USRE32488 *||Sep 12, 1986||Sep 1, 1987|| ||Hip prosthesis|
|DE3311326A1 *||Mar 29, 1983||Nov 3, 1983||Vitek Inc||Implantierbare gliedergelenkprothese|
|DE3527136A1 *||Jul 29, 1985||Mar 13, 1986||Bristol Myers Co||Implantat und verfahren zur herstellung desselben|
|DE3527136C2 *||Jul 29, 1985||Apr 13, 1989||Bristol-Myers Co., New York, N.Y., Us||Title not available|
|DE3822154A1 *||Jun 30, 1988||Mar 9, 1989||Bristol Myers Co||Prothetisches implantat mit einer dieses umhuellenden poroesen flaeche|
|DE3822154C2 *||Jun 30, 1988||Oct 24, 2002||Bristol Myers Squibb Co||Prothetisches Implantat mit einem porösen Kissen und Verfahren zu dessen Herstellung|
|DE3909545A1 *||Mar 22, 1989||Oct 5, 1989||Bristol Myers Co||Knochenimplantat|
|DE3909545C2 *||Mar 22, 1989||Oct 1, 1998||Squibb Bristol Myers Co||Knochenimplantat|
|EP0038902A2 *||Jan 24, 1981||Nov 4, 1981||Gebrüder Sulzer Aktiengesellschaft||Superficial structure for anchoring elements of bone implants|
|EP0062387A1 *||Apr 1, 1982||Oct 13, 1982||Delphi Dental Industries B.V.||Implant of ceramic material|
|EP0178448A1 *||Sep 7, 1985||Apr 23, 1986||S + G Implants Gmbh||Denture for substituting an extracted tooth|
|EP0178650A2 *||Oct 16, 1985||Apr 23, 1986||Paul Ducheyne||Porous flexible metal fiber material for surgical implantation|
|EP0189546A1 *||Nov 23, 1985||Aug 6, 1986||Gebrüder Sulzer Aktiengesellschaft||Porous metallic layer for covering at least partly implant surfaces|
|EP0489006A1 *||Dec 28, 1989||Jun 10, 1992||Univ Philadelphia||Fiber bundle reinforced bone cement and method.|
|EP0709070A2 *||Oct 17, 1995||May 1, 1996||Osteonics Corp.||Interlocking structural elements and method for bone repair, augmentation and replacement|
|EP1656959A2||Nov 8, 2005||May 17, 2006||DePuy Products, Inc.||System attaching soft tissue to an implant|
|WO1982001989A1 *||Nov 24, 1981||Jun 24, 1982||Medical Biolog Sciences Inc||Oral prosthesis and method for producing same|
|WO1989007917A1 *||Mar 2, 1989||Sep 8, 1989||Bioconcepts Inc||Frangible modular joint prosthesis|
|WO1995034251A1 *||Jun 16, 1995||Dec 21, 1995||Smith & Nephew Richards Inc||Biocompatible low modulus dental devices|
|WO2009032766A1 *||Aug 28, 2008||Mar 12, 2009||Jeffrey A Bassett||Dental implant prosthetic device with improved osseointegration and esthetic features|
|WO2010097413A1||Feb 24, 2010||Sep 2, 2010||Jossi Holding Ag||Implant, at least partially comprising a composite material, intermediate composite product and method for producing an implant|
| || |
|U.S. Classification||623/23.55, 606/76, 419/24, 428/605, 433/201.1, 29/419.1, 428/613|
|International Classification||A61F2/30, A61F2/36, A61C8/00, A61F2/00, A61F2/32, A61B17/72, A61L27/04|
|Cooperative Classification||A61F2/3607, A61F2250/0063, A61F2/32, A61F2/3662, A61F2/30907, A61B17/72, A61L27/04, A61C8/0012, A61F2002/30599, A61F2002/30968|
|European Classification||A61L27/04, A61F2/36B, A61B17/72, A61C8/00E, A61F2/32, A61F2/30L4|