|Publication number||US3906950 A|
|Publication date||Sep 23, 1975|
|Filing date||Apr 2, 1974|
|Priority date||Apr 4, 1973|
|Also published as||DE2415961A1, DE7411543U|
|Publication number||US 3906950 A, US 3906950A, US-A-3906950, US3906950 A, US3906950A|
|Original Assignee||Isf Spa|
|Export Citation||BiBTeX, EndNote, RefMan|
|Patent Citations (7), Referenced by (170), Classifications (8)|
|External Links: USPTO, USPTO Assignment, Espacenet|
tinited States @ocozza 1 INHALING DEVICE FOR POWDERED MEDICAMENTS  lnventor: Salvatore Cocozza, Milan, Italy [73} Assignee: I.S.F. S.p.A., Milan, ltaly  Filed: Apr. 2, 1974  Appl. No.: 457,270
 Foreign Application Priority Data Apr. 4, 1973 Italy 22576/73 June 22, 1973 Italy; 25698/73  US. Cl. 128/266; 128/206  Int. Cl. A61M 13/00; A61M 15/08  Field of Search 128/266, 206, 208, 194, 128/265  References Cited UNITED STATES PATENTS 2,307,986 l/1943 Bolt et al. 128/266 so ,2 20* y 2,517,482 8/1950 Hall 128/206 2,519,555 8/1950 128/266 2,581,182 l/1952 128/206 2,946,332 7/1960 Sacks 128/266 3507277 4/1970 Altounyan et al 128/208 3,669,113 6/1972 Altounyan et a1. 128/266 Primary Examiner-Aldrich F. Medbery Attorney, Agent, or Firm-Depaoli & OBrien  ABSTRACT An inhaling device for medicinal powders comprising a pump and an inhaler wherein the inhaler has a cavity formed by the interconnection of two-compartments for holding a puncturable capsule containing a medici nal powder. Two sliding needles acting against the action of return springs pierce the capsule. In a preferred embodiment, the lower body portion of the inhaler is attached to the pump when in use and may be stored in at rest position when the inhaler is inverted into the pump.
22 Claims, 6 Drawing Figures r L 56o US Patent Sept. 23,1975 Sh6t 1 01 2 3,906,950
US mm Sept. 23,1975 Sheet 2' 0f 2 3,9,%
INHALING DEVICE FOR POWDERED MEDICAMENTS BACKGROUND OF THE INVENTION 1. Field of the Invention The invention relates to an inhaler for the administration of medicinal powders. More particularly, the inhaler relates to a traditional pump and an inhaler body having means for piercing a stored capsule containing medicinal powder.
2. Description of the Prior Art Inhalers are already known utilizing an elastic pump and a needle piercing a capsule which contains a me' dicinal substance; generally their working is not completely satisfactory as a result of rather complicated construction and cumbersome dimensions. In the in haler of the present invention, the above mentioned inconveniences have been practically eliminated, so that the inhaler is easily and quickly constructed and of reduced dimensions.
SUMMARY OF THE INVENTION It is the object of this invention to providean inhaler having simplified construction and reduced dimensions for use in combination with a conventional pump as an inhaling device for supplying medicinal powders to a body cavity.
It is another object to provide an inhaler having means for partial storage within the pump therefor.
It is an additional object to provide an inhaler having a means wheel to facilitate locking engagement with the pump.
It is a further object to provide an inhaler having a plurality of slidable alignment means. I
It is also an object to provide an inhaler having a spring-biased means for penetrating each end of a capsule stored therewithin.
In satisfaction of these objects and in accordance with the spirit of this invention, the inhaler contains a cavity-penetrating element. at one end thereof, through which air-entrained powder is forced out into a body cavity. a central element with an inside cavity for locating a capsule of medicinal powder therewithin. a pair of piercing devices for the endwise perforation of the capsule, and a base element having a polished surface interrupted by a ratchet wheel for connection with the pump. In more detail, the central element ofthe inhaler body is relatively fixed and formed by two components which are connected to each other, for example, by threading, bayonet insertion, and similar techniques. These components define a cavity therewithin, for placement of the capsule, and are slidably attached to a pair of relatively movable elements which hold piercing needles and which telescopically slide inside the two above-mentioned capsule holder components against the action of a pair of return springs.
The base element of the inhaler is so shaped that when the device is not in use, the inhaler body may be inverted into the pump, therby resulting in a noticeable reduction in overall size and a pleasant compact aspect of the whole which is aesthetically and practically favorable.
The inhaling device is adapted for delivering powdered substances in aerated form from a pierced capsule and comprises a pump and an inhaler, the inhaler comprising a relatively fixed central element formed by two connectable components and defining a cavity for reception of the capsule. and a pair of relatively moveable needle holder elements telescopically slidablc within the connectable components against the action of a pair of return springs. The components may be connected by screw means, a bayonet clutch means. or the like. Each of the pair of needle holder elements comprises a capsule-piercing needle. Each of the components is attached to a sleeve having an interior shoulder and each of the pair of needle holder elements has an outwardly disposed shoulder which is capable of reciprocating between a rest position against one of the interior shoulders and a ncedle-piercing position against one of the connectable components. The inhaler also comprises a nose piece and a pump piece and one of the pair of holder elements is locked by friction to the noscpiecc and the other of the pair of needle holder elements may be locked against the piece by mi cro-ribs having saw teeth.
BRIEF DESCRIPTION OF THE DRAWINGS The inhaler which constitutes the present invention is shown in the accompanying drawings of the preferred embodiment in which:
FIG. 1 represents a side elevation of the assembled inhaling device comprising the inhaler inserted in a pump in operative condition.
FIG. 2 is a side elevation similar to FIG. I with the inhaler inverted in the pump to reduce the size of the device while partially stored therewithin.
FIG. 3 is a longitudinal section through the inhaler while in uncompressed condition.
FIG. 4 is a longitudinal section of the inhaler. similar to FIG. 3 but with the inhaler in a compressed condition, while in operative combination with a pump.
FIG. 5 is a cross-section taken along lines 55 of FIG. 3, and
FIG. 6 is a side elevation of the noseward component of the cavity-forming element.
DESCRIPTION OF THE PREFERRED EMBODIMENT Referring to the drawings. the inhaler 8 of this invention is employed in combination with a conventional pump 100 and comprises a central storage unit 10 having a central cavity defined by walls 13 within which a medicinal powder-container capsule 15 is inserted as needed by unscrewing a pair of compartments 20, 30. A pair of stop sleeves 60, 70 are non-slidably attached to the unit 10 and are outside of and in sliding relation to a pair of needle holders 40, containing a pair of capsule-puncturing needles 41, 51. The pair of stop sleeves 60, is also within and in sliding relation to a pair of end pieces, the nose piece and the pump piece 90, to which the holders 40, 50 are rigidly attached. The holders 40, 50 are biased away from the central cavity by a pair of springs 25, 35.
Coaxially disposed throughout the entire inhaler of this invention are a series of central holes for passage of air which enters the inhaler from the pump through base opening 98 and air passage 58, passes through the four air passages 59 shown in FIG. 5 to central hole 32 around pump needle 51, enters and passes through the punctured capsule 15 while entraining medicinal powder therefrom. travels past nose needle 41 through central hole 22, passes through the four air passages 49 into swirl compartment 83, and exits from the inhaler through discharge hole 81 in nosepiece 80.
The unit is formed by screwably connecting the nose compartment and the base compartment 30. The compartments 20, have coaxially disposed central holes 22, 32, annularly disposed spring wells 24, 34 which open away from the capsule 15, outer cylindrical recesses with surfaces 23, 33, and connecting screw threads 29, 39 by means of which the compartments 20, 30 are connected. Nose return spring 25 is seated within spring well 24, and pump return spring is seated within spring well 34.
Nose needle holder 40 and pump needle holder have somewhat l-l-shaped cross sections and comprise. respectively, annular fixed ends 46, 56 and annular sliding ends 47, 57 which rest against the springs 25, 35 within the spring wells 24, 34, as shown in FIG. 4. The holders 40, 50 also comprise four air passages 49, 59 which are separated by four radially spaced longitudinally disposed ribs, ribs 54 only being identified in FIG. 5. Each set of ribs 44, 54 supports a central portion containing a central needle recess which opens only toward the central cavity. The butt 42 of nose needle 41 and the butt 52 of pump needle 51 are each rigidly attached within these respective central needle recesses so that the respective needle points 43, 53 are coaxially aligned, centrally disposed within the central holes 22, 32, and in puncturing relationship to the ends of the capsule 15 within the range of compressibility of the springs 25, 35.
Additionally, the holders 40, 50 respectively comprise circumannular shoulders 45, 55 which extend outwardly exactly as far as the walls 23, 33 of the sleeve recesses of each compartment 20, 30. The circular sides 48, 58 of the shoulders 45, 55, opposite to the cavity for the capsule 15, function as a stop means in cooperation with the nose sleeve 60 and the pump sleeve 70, respectively, and the outer cylindrical surfaces of the shoulders 45, 55 are in sliding contact with the inner cylindrical surfaces 61, 71 of the sleeves 60, 70, thus functioning cooperatively therewith as an alignment means.
The nose and pump sleeve 60, respectively comprise elongated cylindrical portions, having outer sides 62, 72 and inner sides 61, 71, and inwardly extending interior shoulders 65, 75, having respective cavityfacing circular surfaces 66, 76, inner cylindrical surfaces 68, 78, and endward-facing circular surfaces 67, 77. The surfaces 68, 78 function as a sliding alignment means in cooperation with the cylindrical surfaces 46a, 56a of the fixed ends 46, 56 of the needle holders 40, 50. The inner side 61, 71 are non-slidably attached to the recessed outer surfaces 23, 33 and function cooperatively with the cylindrical outer surfaces of the shoulders 45, 55 as another sliding alignment means. Nonslidable attachment may be attained by means of suitable adhesive or by circumferential knurlings of the facing surfaces such as the knurlings 26 which are indicated in FIG. 6.
The nose piece 80 comprises a tapered penetration portion 82 through which passes the central discharge hole 81 therein. a skirt portion 84 which extends toward the cavity 15, and a stepped portion 85 therebetween. An annular recess coincides with the inner edge of the step portion 85 and penetrates longitudinally into the penetration portion 82. Into this annular recess, the fixed end 46 of the nose needle holder 40 is rigidly attached. as with an adhesive. The outer surface 62 of the nose sleeve 60 is in sliding engagement with the inner surface of the skirt 84 and functions cooperatively therewith as an alignment means.
The pump piece comprises an outer rim 91, a base 92 having an inwardly projecting circular lip to define the base opening 98, a circular lug 94 spaced pumpward from the edge of the rim 91, and circumferential serrations 97 along the inner surface of the base 92 and noseward of its circular lip. The lug 94 has a circular and arcuately receding surface 95, which acts as a storage stop means when the inhaler is in its inverted storage position shown in FIG. 2, and a circular and radially extending surface 96 which acts as an operational stop means when the inhaler is inserted into a conventional pump 100, as shown in FIGS. 1, 3, and 4. The serrations 97, which may be considered as ribbings, corrugations, or knurlings, are matched and engaged by similar serrations in the surfaces 56a.
The pump 100 typically has side walls 101, a circular top edge 102 which engages the surface 96 when the inhaler 8 is in operative position, and an air-containing interior 104 which should have sufficient depth to accommodate the inhaler 8 from the surface to the tip of the penetration portion 82 when the inhaler 8 is in stored position partially within the pump 100.
In summary, the inhaler 8 comprises three pairs of slidable alignment means:
I. inner cylindrical surfaces of skirt 84 and rim 91 in sliding contact with outer cylindrical surfaces 62, 72; 2. inner cylindrical surfaces 61, 71 in sliding contact with outer cylindrical surfaces of the shoulders 45, 55; and 3. inner cylindrical surfaces 68, 78 in sliding contact with outer cylindrical surfaces 46:1, 560. Because of these three pairs of slidable alignment means, the inhaler 8 possesses a high degree of trueness so that binding and wear are minimized.
In FIGS. 1-4, the profile of the cylindrical surface of the lower body portion of the inhaler 8, which is connected by friction with a pump of suitable dimensions and configuration, is polished and uniform and interrupted by the lug 94 where circular lines of contact 95 and 96 with the cylindrical surface represent the stop points in locking engagement with the pump 100 when the inhaler 8 is ready to use and when it is in storage position, respectively.
The inhaling device operates as follows:
Initially, the inhaler 8, inverted in the pump 100 (as shown in FIG. 2 is extracted therefrom and connected by friction locking in its upright position to the pump 100. Compartment 20 is then screwed off from compartment 30 and the capsule 15 of powder is inserted therein, after which nosepiece 80 and pumppiece 90 are moved towards one another, i.e., a contraction of the inhaler is caused along arrows AB, which creates two diametrally opposed perforations in capsule 15. Compare FIG. 1 with FIG. 4. Thereafter, it is possible to press the pump 100 to provoke the passage of the powder content of the capsule into a human cavity, such as nasal cavity or other cavities of the human body.
The present invention is not to be limited to the specific embodiment having the scope and advantages described hereinbefore, for various modifications can be made without departing from the spirit of the invention which should he understood asbeihglimited onlyiby the scope of the accompanying"claimst a 1. An inhalingdeyice, for-delivering powderedsubstances in aerated form from a pierced capsule, comprisinga pumpand. an inhaler, said inhalercomprising:
A. a, relatively fixed central element formed by two connectahle components and def ini ng a cavity. for reception of said capsule, and
B. a pair of relatively movcable ncc dleiholde'r ielm ments including piercing means mounted therein, which are: i IN 4 i r H l. telescopically slidable within said'corinectable components against the action of a pair of return springs and in the path of movement of air through said inhaler,
2. disposed in mutually opposed relationship and in straddling relationship to said capsule, and
3. constituting a means for piercing said capsule when said springs are compressed by slidably moving said needle holder elements toward each other.
2. The inhaling device of claim 1 whereinsaid components are connected by screw means.
3. The inhaling device of claim 1 wherein each of said pair of needle holer elements comprises a capsulepiercing needle.
4. The inhaling device of claim 1 wherein each of said components is attached to a sleeve having an interior shoulder and each of said pair of needle holder elements has an outwardly disposed shoulder which is capable of reciprocating between a rest position against one of said interior shoulders and a needle-piercing position against one of said conncctable components.
5. The inhaling device of claim 4 wherein said inhaler comprises a nose piece and a pump piece and one of said pair of said needle holder elements is locked by friction to said nose piece and the other of said pair of needle holder elements is locked against said pump piece by micro-ribs having saw teeth.
6. An inhaler for storing, entraining, and delivering powders in aerated condition, comprising;
A. a central storage unit for said powders,
B. a pair of needle holders including piercing means mounted therein which straddle said unit and are slidably connected thereto,
C. a nose piece which is non-slidably attached to one of said pair of needle holders,
D. a pump piece which is non-slidably attached to the other of said pair of needle holders, and
E. a longitudinally disposed air passage means extending from end to end of said inhaler, through said pump piece, said pair of needle holders, said central storage unit, and said nose piece, said nose piece and said pump piece ecah being longitudinally slidable toward said central storage unit to provide opposed piercing means for the central storage unit, whereby said powders are released.
7. The inhaler of claim 6 wherein said central storage unit comprises a pair of connectable compartments which define and contain. in combination, a cavity thcrewithin for storage of a capsule containing said powder.
8. The inhaler of claim 7 wherein each of said pair of conncctable compartments comprises an annular spring well within which a compression spring is seated.
'9. T he inhaler of claim.8 wherein each of said pair of needle holderscomprises a annular sliding end which is;slidably mounted within one of said annular spring wells andinengagement-with one .Of said springs.
10. The inhaler of claim 9.which further comprises a pair of stop:slceves which straddle said. unit and are non-slidably attached thereto.
11:. The inhaler of claim 10 wherein said pair of stop sleeves is in slidably circumferential and alignmentma'intaining relation to said pair of needle holder element's. 1 I
"12.The inhaler of claim 11- wherein each of said pair of stop sleeves has a cylindrical inner wall and said needle holders comprise circumanntilar shoulders which extend outwardly into slidable and alignmentmaintaining relation with said cylindrical inner walls of said stop sleeves.
13. The inhaler of claim 12 wherein each of said pair of needle holders additionally comprises an annular fixed end, one of said fixed ends being non-slidably attached to said nose piece and the other being nonslidably attached to said pump piece.
14. The inhaler of claim 13 wherein each of said pair of needle holders comprises a capsule-piercing needle, said needles being coaxially disposed in mutually opposed relationship and in straddling relationship to said capsule and being adapted to pierce said capsule when said springs are compressed by slidably moving said nose piece and said pump piece toward each other.
15. The inhaler of claim 14 wherein each of said stop sleeves additionally comprises an inwardly extending interior shoulder which extends into sliding engagement with exterior cylindrical surfaces of said fixed ends, as a sliding alignment means.
16. The inhaler of claim 15 wherein:
A. said nosepiece, said stop sleeves, and said central storage unit have a smaller exterior diameter than the exterior diameter of said pump piece, and
B. said pump piece comprises a circumferential and outwardly extending lug having an arcuately recedingsurface and a radially receding surface,
whereby said arcuately receding surface functions as a storage stop means, when said inhaler is inverted into a pump for storage by inserting said nose piece thereinto, and said radially receding surface functions as an operational stop means, when said inhaler is inserted into said pump by engaging said pump piece therewith.
17. The inhaler of claim 16 wherein said pump piece further has an exterior cylindrical surface which is polished and uniformly interrupted by a friction locking means for the mouthpiece of said pump.
18. The inhaling device of claim 17 wherein the points of contact between the cylindrical surface of the lower body portion and the surface normal to said means are friction locking points between said inhaler and said pump.
19. The inhaling device of claim 17 wherein the points of contact between the cylindrical surface of the lower body portion and the portions of said means have curved surfaces which are stop points for friction locking between said inhaler and said pump when said inhaling device is not in use.
20. The inhaling device of claim 5 wherein:
A. said nose piece and said. pump piece each comprises a skirt portion extending toward said cavity and having an inner cylindrical surface adapted for sliding contact; and
B. each said sleeve comprises an outer cylindrical surface adapted for said sliding contact with one of said inner cylindrical surfaces of said skirt portions of said nose piece and said pump piece to form a first pair of slidable alignment means.
21. The inhaling device of claim wherein:
Apeach said sleeve, attached to one of said two conncctahle components. comprises an inner cylindrical surface adapted for sliding contact; and
B. each said outwardly disposed shoulder of said pair of needle holder elements comprises an outer cylindrical surface adapted for said sliding contact with one of said sleeves to form a second pair of slidable alignment means.
22. The inhaling device of claim 21 wherein:
A. each said interior shoulder of said sleeves attached to said two components comprises an inner cylindrical surface adapted for sliding contact: and
Bi each said needle holder element comprises an outer cylindrical surface adapted for said sliding contact with one of said inner cylindrical surfaces of said interior shoulders to form a third slidable alignment means. said first, second. and third pairs of slidable alignment means imparting a high degree of trueness to said inhaler so that binding and wear are minimized.
|Cited Patent||Filing date||Publication date||Applicant||Title|
|US2307986 *||Feb 15, 1940||Jan 12, 1943||Bolte||Insufflator|
|US2517482 *||Apr 9, 1949||Aug 1, 1950||Sharp & Dohme Inc||Inhaler|
|US2519555 *||Aug 31, 1945||Aug 22, 1950||Abbott Lab||Sterile medicament insufflator cartridge and insufflator|
|US2581182 *||Mar 14, 1950||Jan 1, 1952||Abbott Lab||Inhaler|
|US2946332 *||Dec 23, 1957||Jul 26, 1960||Nysco Lab Inc||Insufflator|
|US3507277 *||Sep 15, 1967||Apr 21, 1970||Fisons Pharmaceuticals Ltd||Inhalation device|
|US3669113 *||Jun 18, 1969||Jun 13, 1972||England Eunice Cockburn Howell||Inhalation device|
|Citing Patent||Filing date||Publication date||Applicant||Title|
|US4013075 *||Jul 15, 1975||Mar 22, 1977||I.S.F. S.P.A.||Inhalers and insufflators having a cutting means|
|US4069819 *||Aug 5, 1976||Jan 24, 1978||Societa Farmaceutici S.P.A.||Inhalation device|
|US4095596 *||Nov 26, 1976||Jun 20, 1978||Smithkline Corporation||Nasal inhaler|
|US4105027 *||Oct 26, 1976||Aug 8, 1978||Syntex Puerto Rico, Inc.||Inhalation device|
|US4116195 *||Feb 10, 1977||Sep 26, 1978||Allen & Hanburys Limited||Device for dispensing medicaments|
|US4240418 *||Feb 28, 1979||Dec 23, 1980||Schering Aktiengesellschaft||Apparatus for the inhalation of medicinal agents|
|US4338931 *||Apr 28, 1980||Jul 13, 1982||Claudio Cavazza||Device for the quick inhalation of drugs in powder form by humans suffering from asthma|
|US4446862 *||Oct 30, 1980||May 8, 1984||Baum Eric A||Breath actuated devices for administering powdered medicaments|
|US4620847 *||May 6, 1984||Nov 4, 1986||Vsesojuzny Nauchno-Issledovatelsky Institut Meditsinskikh Polimerov||Device for administering powdered substances|
|US4645487 *||Jun 5, 1984||Feb 24, 1987||Vsesojuzny Nauchno-Issledovatelsky Institut Meditsinskikh Polimerov||Device for administering powdered substances|
|US4884565 *||Jul 27, 1988||Dec 5, 1989||Miat S.P.A.||Insufflator for the administration of drugs in the form of a powder pre-dosed into opercola|
|US4889114 *||Jul 2, 1987||Dec 26, 1989||Boehringer Ingelheim Kg||Powdered pharmaceutical inhaler|
|US5033463 *||Oct 22, 1990||Jul 23, 1991||Miat S.P.A.||Multi-dose inhaler for medicaments in powder form|
|US5152284 *||May 24, 1991||Oct 6, 1992||Phidea S.P.A.||Disposable inhaler with pre-pierced capsule|
|US5161524 *||Aug 2, 1991||Nov 10, 1992||Glaxo Inc.||Dosage inhalator with air flow velocity regulating means|
|US5366122 *||Aug 27, 1992||Nov 22, 1994||Ing. Erich Pfeiffer Gmbh & Co. Kg||Dispenser for flowable media|
|US5388572 *||Oct 26, 1993||Feb 14, 1995||Tenax Corporation (A Connecticut Corp.)||Dry powder medicament inhalator having an inhalation-activated piston to aerosolize dose and deliver same|
|US5388573 *||Dec 2, 1993||Feb 14, 1995||Tenax Corporation||Dry powder inhalator medicament carrier|
|US5460173 *||Mar 25, 1994||Oct 24, 1995||Tenax Corporation||Dry powder inhaler medicament carrier|
|US5488946 *||Mar 1, 1994||Feb 6, 1996||Calhoun; Clifford A.||Emergency breathing device for opening cartridges|
|US5617845 *||May 3, 1994||Apr 8, 1997||Boehringer Ingelheim Kg||Inhalation device free from propellent gas|
|US5653191 *||Nov 29, 1995||Aug 5, 1997||Calhoun; Clifford A.||Pressure indicator|
|US5692496 *||Aug 1, 1996||Dec 2, 1997||Innovative Devices, Llc||Dry powder medicament inhalator having an inhalation-activated flow diverting means for triggering delivery of medicament|
|US5715811 *||May 25, 1995||Feb 10, 1998||Unisia Jecs Corporation||Inhaling type medicine administering device and using method therefor|
|US5752505 *||Mar 18, 1997||May 19, 1998||Unisia Jecs Corporation||Inhalation-type medicine delivery device|
|US5810004 *||Oct 9, 1996||Sep 22, 1998||Unisia Jecs Corporation||Medicator for a capsule filled with a powdered drug|
|US5823183 *||Mar 25, 1997||Oct 20, 1998||Innovative Devices||Dry powder medicament inhalator having an inhalation-activated flow diverting means for triggering delivery of medicament|
|US5901703 *||Feb 6, 1995||May 11, 1999||Unisia Jecs Corporation||Medicine administering device for nasal cavities|
|US5921236 *||Mar 11, 1996||Jul 13, 1999||Unisia Jecs Corporation||Medicine administering device for nasal cavities|
|US5988163 *||May 11, 1998||Nov 23, 1999||Innovative Devices||Dry powder medicament inhalator having an inhalation-activated flow diverting means for triggering delivery of delivery of medicament|
|US6013050 *||Apr 24, 1997||Jan 11, 2000||Powderject Research Limited||Particle delivery|
|US6048857 *||Jan 20, 1998||Apr 11, 2000||Ellinwood, Jr.; Everett H.||Dosing method of administering medicaments via inhalation administration|
|US6186141 *||May 9, 1997||Feb 13, 2001||Glaxo Wellcome Inc.||Unit dose dispensing device|
|US6209538 *||Mar 17, 1998||Apr 3, 2001||Robert A. Casper||Dry powder medicament inhalator having an inhalation-activated flow diverting means for triggering delivery of medicament|
|US6273086 *||Jan 28, 1999||Aug 14, 2001||Unisia Jecs Corporation||Inhalant medicator|
|US6341605 *||Jan 22, 1999||Jan 29, 2002||Unisia Jecs Corporation||Inhalant medicator|
|US6546929||Jun 4, 2001||Apr 15, 2003||Inhale Therapeutic Systems, Inc.||Dry powder dispersing apparatus and methods for their use|
|US6550477||Jan 27, 2000||Apr 22, 2003||Innovative Devices, Llc|
|US6561186||Nov 27, 2001||May 13, 2003||Innovative Devices|
|US6681768||Jun 21, 2002||Jan 27, 2004||Sofotec Gmbh & Co. Kg||Powder formulation disintegrating system and method for dry powder inhalers|
|US6705313 *||May 9, 2002||Mar 16, 2004||Ph&T S.P.A.||Device usable in the treatment of affections of the airways|
|US6732732||Oct 10, 2002||May 11, 2004||Advanced Inhalation Research, Inc.||Inhalation device and method|
|US6901929||Dec 19, 2002||Jun 7, 2005||Nektar Therapeutics||Dry powder dispersing apparatus and methods for their use|
|US6923178||May 9, 2002||Aug 2, 2005||Innovative Devices, Llc.||Medicament container with same side airflow inlet and outlet|
|US6948494||May 10, 2000||Sep 27, 2005||Innovative Devices, Llc.||Medicament container with same side airflow inlet and outlet and method of use|
|US6978941||Apr 9, 2004||Dec 27, 2005||Aerogen, Inc.||Base isolated nebulizing device and methods|
|US7032590||Jan 5, 2004||Apr 25, 2006||Aerogen, Inc.||Fluid filled ampoules and methods for their use in aerosolizers|
|US7032593||Apr 17, 2002||Apr 25, 2006||Advanced Inhalation Research, Inc.||Inhalation device and method|
|US7040549||Mar 21, 2003||May 9, 2006||Aerogen, Inc.||Systems and methods for controlling fluid feed to an aerosol generator|
|US7066398||Mar 30, 2001||Jun 27, 2006||Aerogen, Inc.||Aperture plate and methods for its construction and use|
|US7100600 *||Mar 20, 2001||Sep 5, 2006||Aerogen, Inc.||Fluid filled ampoules and methods for their use in aerosolizers|
|US7104463||Oct 6, 2005||Sep 12, 2006||Aerogen, Inc.||Base isolated nebulizing device and methods|
|US7112341||Apr 13, 2000||Sep 26, 2006||Nektar Therapeutics||Pulmonary administration of dry powder formulations for treating infertility|
|US7146978||Feb 5, 2004||Dec 12, 2006||Advanced Inhalation Research, Inc.||Inhalation device and method|
|US7163013 *||Oct 3, 2002||Jan 16, 2007||Alchemy Healthcare Limited||Apparatus for the nasal or oral delivery of a medicament|
|US7174888||Sep 5, 2003||Feb 13, 2007||Aerogen, Inc.||Liquid dispensing apparatus and methods|
|US7195011||Jun 30, 2004||Mar 27, 2007||Aerogen, Inc.||Convertible fluid feed system with comformable reservoir and methods|
|US7201167||Mar 14, 2005||Apr 10, 2007||Aerogen, Inc.||Method and composition for the treatment of lung surfactant deficiency or dysfunction|
|US7267121||Sep 30, 2004||Sep 11, 2007||Aerogen, Inc.||Aerosol delivery apparatus and method for pressure-assisted breathing systems|
|US7278425||Feb 5, 2004||Oct 9, 2007||Alkermes, Inc.||Inhalation device and method|
|US7290541||Jun 30, 2004||Nov 6, 2007||Aerogen, Inc.||Aerosol delivery apparatus and method for pressure-assisted breathing systems|
|US7318436||Oct 25, 2004||Jan 15, 2008||Innovative Devices, Llc||Medicament container with same side airflow inlet and outlet and method of use|
|US7322349||Jun 18, 2003||Jan 29, 2008||Aerogen, Inc.||Apparatus and methods for the delivery of medicaments to the respiratory system|
|US7331339||Nov 23, 2004||Feb 19, 2008||Aerogen, Inc.||Methods and systems for operating an aerosol generator|
|US7353823 *||May 13, 2003||Apr 8, 2008||Bioactis Limited||Powder chemical feeding device for nasal cavity|
|US7360536||Jan 7, 2003||Apr 22, 2008||Aerogen, Inc.||Devices and methods for nebulizing fluids for inhalation|
|US7422013||Mar 9, 2005||Sep 9, 2008||Nektar Therapeutics||Dry powder dispersing apparatus and methods for their use|
|US7464706||Sep 4, 2003||Dec 16, 2008||Mannkind Corporation||Unit dose cartridge and dry powder inhaler|
|US7559325||Apr 9, 2004||Jul 14, 2009||Novartis Pharma Ag||Aerosolization apparatus with air inlet shield|
|US7600511||Oct 30, 2002||Oct 13, 2009||Novartis Pharma Ag||Apparatus and methods for delivery of medicament to a respiratory system|
|US7611709||May 2, 2005||Nov 3, 2009||Boehringer Ingelheim Pharma Gmbh And Co. Kg||1,4 O-linked saccharose derivatives for stabilization of antibodies or antibody derivatives|
|US7628339||May 5, 2006||Dec 8, 2009||Novartis Pharma Ag||Systems and methods for controlling fluid feed to an aerosol generator|
|US7648960||Nov 21, 2003||Jan 19, 2010||Mannkind Corporation||Method for delivery of monomeric or dimeric insulin complexed to diketopiperazine microparticles|
|US7669597||May 15, 2008||Mar 2, 2010||Mystic Pharmaceuticals, Inc.||Combination unit dose dispensing containers|
|US7677467||Apr 20, 2005||Mar 16, 2010||Novartis Pharma Ag||Methods and devices for aerosolizing medicament|
|US7713929||Apr 2, 2007||May 11, 2010||Biodel Inc.||Rapid acting and long acting insulin combination formulations|
|US7718609||Apr 11, 2007||May 18, 2010||Biodel Inc.||Rapid acting and long acting insulin combination formulations|
|US7723306||May 2, 2005||May 25, 2010||Boehringer Ingelheim Pharma Gmbh & Co. Kg||Spray-dried powder comprising at least one 1,4 O-linked saccharose-derivative and methods for their preparation|
|US7727962||May 2, 2005||Jun 1, 2010||Boehringer Ingelheim Pharma Gmbh & Co. Kg||Powder comprising new compositions of oligosaccharides and methods for their preparation|
|US7748377||Oct 30, 2007||Jul 6, 2010||Novartis Ag||Methods and systems for operating an aerosol generator|
|US7771642||Apr 1, 2005||Aug 10, 2010||Novartis Ag||Methods of making an apparatus for providing aerosol for medical treatment|
|US7806117 *||Jun 7, 2006||Oct 5, 2010||Shin Nippon Biomedical Laboratories, Ltd.||Peroral powder delivery device|
|US7943178||Dec 10, 2009||May 17, 2011||Mannkind Corporation||Methods and compositions for delivering peptides|
|US7946291||Apr 20, 2004||May 24, 2011||Novartis Ag||Ventilation systems and methods employing aerosol generators|
|US7963089||Sep 15, 2008||Jun 21, 2011||Mystic Pharmaceuticals, Inc.||Deep draw container forming method|
|US7971588||Mar 24, 2005||Jul 5, 2011||Novartis Ag||Methods and systems for operating an aerosol generator|
|US8006695||Nov 10, 2005||Aug 30, 2011||Cipla Limited||Inhaler|
|US8069851||Jun 22, 2009||Dec 6, 2011||Novartis Ag||Aeorosolization apparatus with air inlet shield|
|US8084420||Nov 26, 2008||Dec 27, 2011||Biodel Inc.||Rapid acting and long acting insulin combination formulations|
|US8156936||Apr 17, 2012||Mannkind Corporation||Unit dose capsules and dry powder inhaler|
|US8161969||Mar 21, 2008||Apr 24, 2012||Novartis Ag||Dry powder dispersing apparatus and methods for their use|
|US8196573||Jan 23, 2008||Jun 12, 2012||Novartis Ag||Methods and systems for operating an aerosol generator|
|US8215300||Apr 14, 2008||Jul 10, 2012||Mannkind Corporation||Unit dose cartridge and dry powder inhaler|
|US8336545||Jan 16, 2007||Dec 25, 2012||Novartis Pharma Ag||Methods and systems for operating an aerosol generator|
|US8357696||Jan 28, 2010||Jan 22, 2013||Mpex Pharmaceuticals, Inc.||Aerosolized fluoroquinolones and uses thereof|
|US8377009||Jan 9, 2008||Feb 19, 2013||Mystic Pharmaceuticals, Inc.||Intranasal cartridge devices|
|US8389470||Jan 5, 2011||Mar 5, 2013||Mannkind Corporation||Methods and compositions for delivering peptides|
|US8394414||Nov 12, 2003||Mar 12, 2013||Mannkind Corporation||Method for drug delivery to the pulmonary system|
|US8398001||Jun 19, 2006||Mar 19, 2013||Novartis Ag||Aperture plate and methods for its construction and use|
|US8496002||Jun 10, 2008||Jul 30, 2013||Civitas Therapeutics, Inc.||Powder inhaler devices|
|US8501240||Dec 23, 2008||Aug 6, 2013||Novartis Ag||Compositions comprising an active agent|
|US8522775 *||Jun 15, 2007||Sep 3, 2013||Cipla Limited||Dry powder inhaler|
|US8524734||Oct 22, 2009||Sep 3, 2013||Mpex Pharmaceuticals, Inc.||Aerosolized fluoroquinolones and uses thereof|
|US8524735||Oct 22, 2009||Sep 3, 2013||Mpex Pharmaceuticals, Inc.||Aerosolized fluoroquinolones and uses thereof|
|US8539944||Apr 8, 2008||Sep 24, 2013||Novartis Ag||Devices and methods for nebulizing fluids for inhalation|
|US8539946||Feb 19, 2007||Sep 24, 2013||Eric Zembrod||Dry powder inhaler|
|US8546423||Oct 22, 2009||Oct 1, 2013||Mpex Pharmaceuticals, Inc.||Aerosolized fluoroquinolones and uses thereof|
|US8561604||Feb 12, 2007||Oct 22, 2013||Novartis Ag||Liquid dispensing apparatus and methods|
|US8561609||Dec 7, 2011||Oct 22, 2013||Respira Therapeutics, Inc.||Dry powder inhaler|
|US8584669||Apr 11, 2007||Nov 19, 2013||Boehringer Ingelheim International Gmbh||Inhaler|
|US8616195||Apr 27, 2004||Dec 31, 2013||Novartis Ag||Nebuliser for the production of aerosolized medication|
|US8623817||Jan 17, 2012||Jan 7, 2014||Mannkind Corporation||Method of treating diabetes type 2 by administering ultrarapid acting insulin|
|US8629139||Oct 6, 2009||Jan 14, 2014||Mpex Pharmaceuticals, Inc.||Topical use of Levofloxacin for reducing lung inflammation|
|US8651104||May 11, 2012||Feb 18, 2014||Respira Therapeutics, Inc.||Bead-containing dry powder inhaler|
|US8664187||Feb 24, 2012||Mar 4, 2014||Novartis Ag||Methods of treatment of endobronchial infections|
|US8671937||Mar 15, 2012||Mar 18, 2014||Mannkind Corporation||Unit dose capsules and dry powder inhaler|
|US8673360||Aug 5, 2005||Mar 18, 2014||Shin Nippon Biomedical Laboratories, Ltd.||Compositions that enable rapid-acting and highly absorptive intranasal administration|
|US8683995||Sep 15, 2011||Apr 1, 2014||Mystic Pharmaceuticals, Inc.||Dose dispensing containers|
|US8715623||Oct 31, 2007||May 6, 2014||Novartis Ag||Pulmonary delivery of aminoglycoside|
|US8785396||Nov 9, 2011||Jul 22, 2014||Mannkind Corporation||Method and composition for treating migraines|
|US8815838||Oct 6, 2009||Aug 26, 2014||David C. Griffith||Aerosol fluoroquinolone formulations for improved pharmacokinetics|
|US8827946||Aug 2, 2010||Sep 9, 2014||Shin Nippon Biomedical Laboratories, Ltd.||Intranasal granisetron and nasal applicator|
|US8869794 *||Apr 9, 2004||Oct 28, 2014||Novartis Pharma Ag||Aerosolization apparatus with capsule puncturing member|
|US8875704||May 9, 2014||Nov 4, 2014||Optinose As||Nasal administration|
|US8889099||Jan 30, 2013||Nov 18, 2014||Mannkind Corporation||Methods and compositions for delivering peptides|
|US8919342||Jul 31, 2008||Dec 30, 2014||Boehringer Ingelheim International Gmbh||Inhaler|
|US8933023||Jan 15, 2014||Jan 13, 2015||Biodel Inc.||Rapid acting injectable insulin compositions|
|US8950397||Jun 6, 2012||Feb 10, 2015||Mannkind Corporation||Unit dose cartridge and dry powder inhaler|
|US9006175||Jan 10, 2006||Apr 14, 2015||Mannkind Corporation||Potentiation of glucose elimination|
|US9060927||Mar 3, 2009||Jun 23, 2015||Biodel Inc.||Insulin formulations for rapid uptake|
|US9061111||Feb 29, 2012||Jun 23, 2015||Mannkind Corporation||Unit dose capsules and dry powder inhaler|
|US9101539||May 14, 2010||Aug 11, 2015||Shin Nippon Biomedical Laboratories, Ltd.||Intranasal pharmaceutical compositions with improved pharmacokinetics|
|US9108211||Apr 17, 2006||Aug 18, 2015||Nektar Therapeutics||Vibration systems and methods|
|US20010029947 *||Dec 6, 2000||Oct 18, 2001||Steve Paboojian||Receptacles to facilitate the extraction of powders|
|US20020134382 *||May 9, 2002||Sep 26, 2002||Snow John M.||Medicament container with same side airflow inlet and outlet and method of use|
|US20040077528 *||Nov 21, 2003||Apr 22, 2004||Mannkind Corporation||Purification and stabilization of peptide and protein pharmaceutical agents|
|US20040096403 *||Nov 12, 2003||May 20, 2004||Mannkind Corporation||Method for drug delivery to the pulmonary system|
|US20040154618 *||Feb 5, 2004||Aug 12, 2004||Advanced Inhalation Research, Inc.||Inhalation device and method|
|US20040154619 *||Feb 5, 2004||Aug 12, 2004||Advanced Inhalation Research, Inc.||Inhalation device and method|
|US20040182387 *||Sep 4, 2003||Sep 23, 2004||Mannkind Corporation||Unit dose cartridge and dry powder inhaler|
|US20040206350 *||Nov 14, 2003||Oct 21, 2004||Nektar Therapeutics||Aerosolization apparatus with non-circular aerosolization chamber|
|US20040216738 *||Feb 5, 2004||Nov 4, 2004||Advanced Inhalation Research, Inc.||Inhalation device and method|
|US20050028813 *||Oct 3, 2002||Feb 10, 2005||Ian Harrison||Apparatus for the nasal or oral delivery of a medicament|
|US20050056281 *||Oct 25, 2004||Mar 17, 2005||Snow John M.||Medicament container with same side airflow inlet and outlet and method of use|
|US20050088617 *||Oct 27, 2003||Apr 28, 2005||Jen-Chuen Hsieh||Method and apparatus for visual drive control|
|US20050150492 *||Apr 9, 2004||Jul 14, 2005||Nektar Therapeutics||Aerosolization apparatus with air inlet shield|
|US20050153874 *||Jan 10, 2005||Jul 14, 2005||Mannkind Corporation||Method of reducing serum proinsulin levels in type 2 diabetics|
|US20050177095 *||May 13, 2003||Aug 11, 2005||Tatsuo Tsutsui||Powder chemical feeding device for nasal cavity|
|US20050186146 *||Feb 14, 2005||Aug 25, 2005||Nektar Therapeutics||Interleukin-13 antagonist powders, spray-dried particles, and methods|
|US20050250704 *||May 2, 2005||Nov 10, 2005||Boehringer Ingelheim Pharma Gmbh & Co. Kg||Powder comprising new compositions of oligosaccharides and methods for their preparation|
|US20050250705 *||May 2, 2005||Nov 10, 2005||Boehringer Ingelheim Pharma Gmbh Co. Kg||Spray-dried powder comprising at least one 1,4 O-linked saccharose-derivative and methods for their preparation|
|US20050255119 *||May 2, 2005||Nov 17, 2005||Boehringer Ingelheim Pharma Gmbh & Co. Kg||1,4 O-linked saccharose derivatives for stabilization of antibodies or antibody derivatives|
|US20090090433 *||Apr 13, 2006||Apr 9, 2009||Symyx Technologies Europe Sa||Apparatus And Method For Storing And Dispensing Material, Especially In Micro Quantities And In Combination With Limited Starting Amounts|
|US20090320838 *||Jun 15, 2007||Dec 31, 2009||Cipla Limited||Dry powder inhaler|
|US20100288275 *||Apr 7, 2008||Nov 18, 2010||Optinose As||Nasal administration|
|USRE45404||Mar 27, 2003||Mar 3, 2015||Shin Nippon Biomedical Laboratories, Ltd.||Powder medicine applicator for nasal cavity|
|CN101389367B||Feb 19, 2007||Oct 5, 2011||阿哈塑料技术有限公司||干粉吸入器|
|CN101815552B||Jul 31, 2008||Mar 6, 2013||贝林格尔.英格海姆国际有限公司||吸入器|
|EP0761248A1 *||Mar 11, 1996||Mar 12, 1997||Unisia Jecs Corporation||Intranasal medicator|
|EP1082155A2 *||May 19, 1999||Mar 14, 2001||Inhale Therapeutic Systems||Dry powder dispersing apparatus and methods for their use|
|EP1108439A2 *||Dec 15, 2000||Jun 20, 2001||Ing. Erich Pfeiffer GmbH||Product dispenser|
|EP2594272A2||May 18, 2006||May 22, 2013||Mpex Pharmaceuticals, Inc.||Aerosolized fluoroquinolones and uses thereof|
|WO1996012513A1 *||Oct 20, 1995||May 2, 1996||Oxford Biosciences Ltd||Particle delivery|
|WO1998058695A1 *||Jun 23, 1997||Dec 30, 1998||Marco Cecchini||Inhaling device|
|WO2006051300A1||Nov 10, 2005||May 18, 2006||Cipla Ltd||Inhaler|
|WO2007098870A1 *||Feb 19, 2007||Sep 7, 2007||Aha Kunststoffechnik Gmbh||Dry powder inhaler|
|WO2012037038A1||Sep 12, 2011||Mar 22, 2012||Gilead Sciences, Inc.||2' -fluoro substituted carba-nucleoside analogs for antiviral treatment|
|WO2013016784A1||Aug 4, 2011||Feb 7, 2013||Victor Esteve||Dry powder inhaler|
|WO2013016787A1||Dec 21, 2011||Feb 7, 2013||Victor Esteve||Powder inhaler|
|WO2013158776A1||Apr 17, 2013||Oct 24, 2013||Gilead Sciences, Inc.||Compounds and methods for antiviral treatment|
|U.S. Classification||128/203.15, 128/203.21|
|International Classification||A61M15/00, A61M13/00|
|Cooperative Classification||A61M2015/0033, A61M15/0028, A61M2202/064|