|Publication number||US3907504 A|
|Publication date||Sep 23, 1975|
|Filing date||Apr 6, 1973|
|Priority date||Apr 6, 1973|
|Also published as||CA1006709A, CA1006709A1, DE2415528A1|
|Publication number||US 3907504 A, US 3907504A, US-A-3907504, US3907504 A, US3907504A|
|Inventors||Gary W Hammond, Donald R Ingenito, Gunnar E Walmet|
|Original Assignee||Gen Electric|
|Export Citation||BiBTeX, EndNote, RefMan|
|Patent Citations (10), Referenced by (44), Classifications (12)|
|External Links: USPTO, USPTO Assignment, Espacenet|
United States Patent [191 Hammond et a1.
[ Sept. 23, 1975 Donald R. Ingenito, Scotia; Gunnar E. Walmet, Schenectady, all of NY.
 Assignee: General Electric Company,
 Filed: Apr. 6, 1973  Appl. No.: 348,711
 US. Cl. 23/258.5; 128/DIG. 3; 137/565; 417/36; 417/37; 417/43  Int. Cl. A6lM 1/03  Field of Search 23/258.5; 128/D1G. 3; 417/43, 36, 37; 137/565  References Cited UNITED STATES PATENTS 2,659,368 11/1953 Gibbon et a1. 23/258.5 3,332,746 7/1967 Claff et a1. 23/258.5 3,374,066 3/1968 Farrant 23/258.5 3,413,095 11/1968 Bramson 23/258.5
3,484,211 12/1969 Mon et a1. 23/258.5 3,513,845 5/1970 Chestnut et a1 23/258.5 X 3,533,408 10/1970 Paoli 23/258.5 X 3,717,174 2/1973 DeWall..... 23/258.5 X 3,827,828 8/1974 Edwards 417/43 3,833,013 9/1974 Leonard 23/258.5 X
OTHER PUBLICATIONS General Electric Dialing Instruction Manual; Publication No. 46A209535; Nov. 1972; Sections 4.1.1 to
C. T. Drake et 211.; The Effect of Low During Extracorporeal Circulation; J. Thoracic & Cardiovas. Surg.; Vol. 42; No. 6; 12-61; pp. 735-742.
F. .1. Lewis et al.; Semiautomatic Control Blood Pump; .1. Thoracic & Cardiovas. Surg.; Vol. 43; No. 3; 362; pp. 392-396.
M. Turina et al.; An automatic Infants; .1. Thoracic & Cardiovas. Surg.; Vol. 63; No. 2; 2-72; pp. 263268.
Primary Examiner-Barry S. Richman Attorney, Agent, or Firm-Thomas J. Bird, .lr.; Granville M. Pine; Edward A. Hedman [5 7] ABSTRACT ment, the apparatus is used in an extracorporeal circuit to sense changes in the pressure and volume of blood and to signal the speed controller on a blood transfer pump in the blood circuit.
7 Claims, 8 Drawing Figures Mme/AL PUMP US Patent Sept. 23,1975 Sheet 1 of5 US Patent Sept. 23,1975 Sheet 3 of5 3,907,504
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QDQQQQ tswk QR Sou E BLOOD OXYGENATION SYSTEM INCLUDING AUTOMATIC MEANS FOR STABILIZING THE FLOW RATE OF BLOOD THERETI-IROUGH This invention relates to an apparatus for sensing and signaling changes in the pressure and volume of fluids passing therethrough. More particularly, it is concerned with an apparatus which can sense the amount of liquid in a reservoir, e.g., one used in an extracorporeal fluid circuit and, using this signal, to modulate the speed of a pump in the circuit.
BACKGROUND OF THE INVENTION Various sensors are known which can detect the amount of liquid in a reservoir used in an extracorporeal circuit and, using this signal, modulate the speed ofa pump in the circuit. If the circuit is used, for exam ple, to oxygenate blood, such sensor-controllers operate almost automatically, considerably simplifying the perfusionists task. In this way, for example, a two pump circuit, generally needed with membrane lungs,
is reduced to the operational simplicity of a one-pump circuit by having an automatically controlled arterial pump. Also, such an automatic pump speed controller can be used to sense a venous reservoir being filled by gravity drainage from the patient and thus control the venous pump.
Among the prior art sensors are those which are weighing devices. These suffer serious disadvantages because they have two to four large tubes and two small tubes connected to a compliant or rigid reservoir, and the preload due to these tubes adversely affects the functioning of the weighing mechanism. Another device is based on the principle of an optical detection of the liquid level in the reservoir. However, the optical technique is complicated, lacks reliability, is applicable mainly only to rigid reservoirs, and generally is adapted to give only onoff rather than modulated pump control signals.
In a novel way, the device of the present invention can sense the amount of liquid in a reservoir, e.g., one used in an extracorporeal circuit and, using this signal, modulate the speed of a. pump in the circuit. The present device provides the stated advantages simply, reliably, and in a method consistent with maintaining sterility in the blood.
BRIEF DESCRIPTION OF THE DRAWINGS In the drawings:
FIG. 1 illustrates a vertical plan view, partially in section, of a compliant reservoir pressure and volume sensing and signalingdevice, which is one embodiment of this invention;
FIGS. 2 ((-11 illustrate semi-diagramatically, the device of FIG. 1 in which the compliant reservoir is shown ,to assume typical configurations under the influence of various fluid pressures and volumes;
FIG. 3 is a schematic, partial plan view, showing how the device of FIG. 1 can be used to keep the pump in a gravity drainage, single pump, extracorporeal circuit at the proper speed;
FIG. 4 is a schematic, partial plan view, showing how the device of FIG. 1 can be used to keep either the venous pump or the arterial pump of a two-pump gravity drainage system automatically at proper speed; and
FIG. 5 is a schematic, partial plan view, showing how the device of FIG. I can automatically control the speed of an arterial pump in a two-pump venous pump suction circuit.
Although FIGS. 3-5 relate specifically to a membrane lung of the type described in the copending application of D. R. Ingenito, W. P. Mathewson, D. R. Ryon and Gunnar E. Walmet, Ser. No. 247,987, filed on Apr. 21, 1972, now US. Pat. No. 3,839,204 issued Oct. 1, 1974, and assigned to the assignee of the present invention, it will be understood that the device of this invention can be used equally effectively with other membrane lungs and even different types of fluid gasexchanger and/or heat-exhanger.
DESCRIPTION OF THE INVENTION In its broadest aspects, the invention contemplates a device for continually sensing changes in reservoir distention/pressure and for signaling the changes to operate an external controller. In a preferred feature, the device will include means for varying the maximum volume of the reservoir. This allows one compliant reservoir to be used in an extracorporeal circuit for a variety of patient sizes.
According to the present invention, there is provided an apparatus for sensing and signaling changes in the pressure and volume of a fluid passing therethrough, said apparatus comprising:
a. a hollow chamber;
b. a compliant reservoir for holding said fluid, said reservoir being disposed within said hollow chamber and including an inlet and an outlet port for said fluid; and
c. motion actuated means in said hollow chamber for signaling changes in the size of said compliant reservoir.
Referring to FIG. 1, there is shown a preferred embodiment of the invention, in the form of a compliant reservoir pump speed controller. The sensor-controller is constructed of hollow chamber 2 comprised of U shaped base 4 of metal, plastic or the like and U shaped cover piece 6 also of metal, plastic or other suitable material of construction. Preferably, cover piece 6 and- /or base 4 will be of transparent material, such as clear plastic to allow the fluid in compliant reservoir 8 to be visually observed for any bubbles, clots, suspended foreign matter, and the like. To facilitate mounting, base 4 can be fitted with holder support 10. Adjustment slots 12 and lock screws 14 are providedin cover 6 and base 4 to permit changing the maximum volume of hollow chamber 2.
Compliant reservoir 8 is constructed of any suitable flexible material, such as metal, plastic and the like, preferably poly(vinyl chloride), silicone rubber, etc., and is fitted with inlet 13 and outlet 15, for fluid. It is desirable to provide that inlet 13 be tubular and that it terminate somewhat high up into the reservoir so that any bubbles in the fluid will be trapped by rising to the top of the reservoir instead of being drawn out of outlet 15. In the embodiment shown in FIG. 1, one or more vents, 16, are provided at the top of reservoir 8, and these can also serve conveniently as a sample port. For convenience, reservoir support 18 can be provided to hold the reservoir within the hollow chamber, eg by grasping a ring or other suitable fixture attached thereto.
Another important element in the device of this invention is the means for sensing the amount of liquid in reservoir 8. This can comprise a plate adjacent the reservoir, the plate being movable with changes in reservoir shape induced by fluid pressure and volume changes and a transducer actuated by motion from the sensor plate for supplying a signal to an external .recorder or controller. The sensor plate can be of the linear translating or, preferably, a pivoting type, and preferably is biased, e.g., with a spring, against the reservoir. Many different transducers can be used to convert the motion of the sensor plate to a different form of signal energy, but when used as a pump controller, it is preferred to use a linear motion actuated potentiometer or a linear motion actuated autotransformer.
Referring again to FIG. 1, sensor plate is shown hinged to base 4 at hinge point 22 and is seen to contact compliant reservoir 8 along a fairly substantial area of contact. Leaf spring 24 biases sensor plate 20 against reservoir 8. The transducer comprises linear potentiometer 26 having rod 28, of metal, strategically located to transmit changes in the position of sensor plate 20 to the potentiometer;
In operation, as compliant reservoir 8 fills up with fluid, sensor plate 20 deflects against spring 24. Conversely as reservoir 8 empties, sensor plate 20 follows it and moves out. As sensor plate 20 moves, metal rod 28 connected to linear motion actuated potentiometer 26 has its resistance varied. The resistance is the speed controlling signal in a suitable pump motor speed controller (not shown in FIG. 1).
If it is desired to change the maximum volume of the reservoir, cover plate 6 can be moved with respect to base 4 and locked in the new position with screws 14. This is shown, along with typical pressures and volumes in the reservoir (pressures measured near the top of the reservoir to avoid hydrostatic head contributions), at
various positions in FIG. 2.
For medical use, it is desirable that all parts of the device be'made of plastic. This increases the electrical resistance between the blood and any electrical components used in the sensor to insure patient safety in the event of anelectrical failure. Alternately, metal parts, if used, can be covered with an insulator. The materials in contact with blood should be easily sterilizable and be biocompatible.
DESCRIPTION OF THE PREFERRED EMBODIMENTS FIGS. 3-5 show how the device of this invention can be used as a reservoir sensing pump speed controller in extracorporeal circuits for oxygenating or otherwise treating body fluids, e.g., blood, and the like, before their return to the patient.
Referring to FIG. 3, reservoir sensing pump controller 30 is used in a gravity drainage, single pump, extracorporeal circuit to keep the pump at the proper speed. Blood from the patient (not shown) passes by gravity through conduit 32 into inlet port 13 on sensor device 30. The blood leaves through port 15 and is pumped, e.g., with roller type pump 34 (Sarns Corp., Ann Arbor, Mich, or the like) through conduit 36 past pressure monitoring gauge 38 to the inlet port of membrane type blood-gas exchanger 40 (GE-DUALUNG, General Electric Co., Schenectady, N.Y., or the like) which is fitted with inlet 42 and outlet 44 for heat exchange fluid and inlet conduit 46 for oxygen. The oxygenated blood exits the membrane lung through conduit 48 and, after being led to bubble trap 50, is returned to the patient through conduit 52. Shown schematically in combination with reservoir 8 are hinged sensor plate 20 and linear potentiometer 26 which supplies a pump speed varying signal through conductor 54 to pump 34. As changes in volume or pressure in the system expand or contract reservoir 8, the pumpspeed is varied automatically to compensate,
. Referring to FIG. 4, reservoir sensing pump controller 30 is used to keep either the venous pump or, preferably, the arterial pump of a two-pump gravity drainage system automatically at proper speed. Blood from the patient (not shown) passes by gravity through conduit 56 into inlet port 17 on sensor device 30. The blood leaves through port 15 and is. ,pumped by roller type venous pump 34 through conduit 36 past pressure monitoring gauge 38 to an inlet port of membrane type blood-gas exchanger40. oxygenated blood exits the exchanger through conduit 58 and is split into two streams, one being recycled to controller 30 through conduit 60 and entrance port 13. Complaint reservoir 8 is fitted with one vent tube 16 and a second vent tube includes filter 62 and cardiotomy reservoir 64. The other oxygenated blood stream istransferred through conduit 66and pumped by roller type arterial pump 68 to bubble trap 70 before being returned to the patient. Shown schematically in combination with reservoir 8 are hinged sensor plate 20 and linear potentiometer 26 which supplies a pump speed varying signal. If venous pump 34 is controlled, signal conductor 54 is used. Alternatively, and preferably, if arterial pump 68 is controlled, signal conductor 55 is used. In either case the pump speed is varied automatically to compensate for changes in blood pressure and volume within reservoir 8.
Referring to FIG. 5, reservoir'sensing pump controller 30 is used to keep the arterial pump in a two-pump venous pump suction circuit automatically at the proper speed. Blood from the patient (not shown) flows through conduit 72 into roller type venous pump 34 and pumped through conduit 36 to an inlet port of membrane type blood-gas exchanger 40. Oxygenated blood exits the exchanger through conduit 74 and enters compliant reservoir (arterial) 8 through entrance port 13. Compliant reservoir 8 is fitted with vent tube 16 andwith cardiotomy reservoir 64 coupled to reservoir 8 through filter 62. Part of the oxygenated blood in reservoir 8 exits through port 19 and circulates back through the venous pump circuit via conduit 76. Another part of the volume of oxygenated blood in reservoir 8 exits through port 15 to roller type arterial pump 68 where it is pumped through conduit 78, and, optionally, bubble trap 70, back to the patient. Shown schematically in combination with reservoir 8 are hinged sensor plate 20 and linear potentiometer 26 which supplies a pump speed varying signal through conductor 55 to pump 68, automatically varying the pump speed to compensate for changes in blood pressure and volume within reservoir 8.
Obviously, many other variations are possible in the light of the above specific embodiments. For example, FIGS. 4 and 5 illustrate how the sensor can be located in the venous and arterial two-pump circuits. Several other variations are possible. Illustratively, in FIG. 5.
decoupling conduit 76 between the reservoir and the inlet to venous pump 34 can be clamped off resulting in coupled pump speeds, i.e., arterial pump 68 will follow the settings of venous pump 34. Moreover, the reservoir sensors control in FIG. 4 can be moved to run the circuit exactly as shown in FIG. 5 to achieve automatic operation. In both venous and arterial reservoir circuits, the venous pump is desirably set somewhat faster than the anticipated rate of drainage from the patient. Excess flow will recirculate through a decoupling line (60 in FIG. 4; 76 in FIG. 5). A sensor controlled arterial pump will return just the venous drainage back to the patient. This has two major advantages: (i) lessened manpower drain during partial supports; and (ii) smaller liquid inventories needed in the reservoir during all cases due to the ability of the machine to compensate more rapidly than a human operator. Other variations will include an arterial pump speed sensor with high and low speed set-point alarms, especially useful for automatic operation, because a sudden change of speed will usually indicate a problem with the perfusion. It will be obvious also that the locations of the cardiotomy reservoir can be changed from those shown in FIGS. 4 and 5, without departing from the invention.
The above description demonstrates that the present invention discloses a reservoir sensing and signaling de- 'vice which is simple and offers unique advantages over other pre-existing designs meant to serve the same function.
Many variations of the present invention are possible without departing from the spirit or scope of the appended claims.
1. An apparatus for extracorporeally oxygenating the blood of a living patient comprising in combination i. at least one pumping means for the blood,
ii. oxygenating means for the blood,
iii. means for sensing and signalling changes in the pressure and volume of blood passing through said apparatus, said sensing and signalling means comprising:
a. a hollow chamber of a selectively fixed and adjustable volume and comprising a base piece and w a' cover piece; b. a compliant reservoir for holding said blood, said reservoir being disposed within said hollow chamber and including an inlet and an outlet port for said blood; said hollow chamber substantially limiting the maximum expansion volume of said complaint reservoir, and 5 c. motion activated means in said hollow chamber for generating an electrical signal proportionate to changes in the size of said compliant reservoir, and d. adjusting means movably attaching said cover piece to said base piece to permit selective adjustment of the volume of said hollow chamber by movement of said cover piece relative to said base piece, and
iv. pump speed controlling means being operatively connected to receive said signal from said motion activated means and to automatically adjust the operation of said pumping means so as to move said blood through said apparatus at a flow rate responsive to said signal.
2. An apparatus as defined in claim 1 wherein two pumping means are utilized, one being a venous pumping means located upstream of said oxygenating means and the other being an arterial pumping means located downstream of said oxygenating means and wherein said pump speed controlling means is operatively connected to said arterial pumping means to automatically adjust the flow rate thereof responsive to said signal.
3. An apparatus as defined in claim 1 wherein said oxygenating means for the blood is a membrane type blood-gas exchanging means.
4. An apparatus as defined in claim 1 wherein a single pumping means is utilized in the apparatus.
5. An apparatus as defined in claim 4 wherein the single pumping means is a venous pumping means located upstream of said oxygenating means.
6. An apparatus as defined in claim 1 which also includes a blood heat exchanging means.
7. An apparatus as defined in claim 6 wherein said oxygenating means for the blood is a membrane type bood-tgas exchanging means and the blood heat exchanging means is integral therewith.
|Cited Patent||Filing date||Publication date||Applicant||Title|
|US2659368 *||May 28, 1949||Nov 17, 1953||Jefferson Medical College Of P||Extracorporeal circulation device|
|US3332746 *||Mar 29, 1963||Jul 25, 1967||Single Cell Res Foundation Inc||Pulsatile membrane oxygenator apparatus|
|US3374066 *||Jun 15, 1964||Mar 19, 1968||William E. Farrant||Thermostabilizer for extracorporeal oxygenator|
|US3413095 *||Jun 14, 1965||Nov 26, 1968||Mogens L. Bramson||Membrane oxygenator|
|US3484211 *||Dec 8, 1964||Dec 16, 1969||Us Army||Membrane oxygenator|
|US3513845 *||Sep 15, 1966||May 26, 1970||United Aircraft Corp||Bypass heart pump and oxygenator system|
|US3533408 *||Mar 30, 1966||Oct 13, 1970||Jean Marc Paoli||Extra-corporeal blood circulation|
|US3717174 *||Aug 3, 1971||Feb 20, 1973||R Dewall||Perfusion safety valve|
|US3827828 *||Dec 26, 1972||Aug 6, 1974||Edwards M||Fluid pump control system|
|US3833013 *||Apr 6, 1972||Sep 3, 1974||Baxter Laboratories Inc||Self-valving fluid reservoir and bubble trap|
|Citing Patent||Filing date||Publication date||Applicant||Title|
|US4062360 *||Apr 2, 1976||Dec 13, 1977||Bentley Laboratories, Inc.||Atraumatic fluid handling method and apparatus|
|US4140635 *||Apr 13, 1977||Feb 20, 1979||Esmond William G||Purification device|
|US4299705 *||Sep 7, 1979||Nov 10, 1981||Russell Richard T||Method of treating blood during operative procedures|
|US4309993 *||Mar 6, 1980||Jan 12, 1982||Baxter Travenol Laboratories, Inc.||Liquid flow sensing apparatus|
|US4411786 *||Oct 5, 1981||Oct 25, 1983||Russell Richard T||Method and apparatus for separating blood from other fluids during operative procedures|
|US4416280 *||Dec 10, 1981||Nov 22, 1983||Minnesota Mining And Manufacturing Company||Cardioplegia delivery system|
|US4417884 *||Jul 9, 1981||Nov 29, 1983||Haemonetics Corporation||Centrifuge timer clamp|
|US4451562 *||Apr 26, 1982||May 29, 1984||Cobe Laboratories, Inc.||Blood oxygenator|
|US4469659 *||Apr 26, 1982||Sep 4, 1984||Cobe Laboratories, Inc.||Sampling device for blood oxygenator|
|US4490331 *||Feb 12, 1982||Dec 25, 1984||Steg Jr Robert F||Extracorporeal blood processing system|
|US4568330 *||Jun 2, 1983||Feb 4, 1986||Minnesota Mining And Manufacturing Company||Cardioplegia delivery system with improved bubble trap|
|US4599093 *||Aug 2, 1984||Jul 8, 1986||Steg Jr Robert F||Extracorporeal blood processing system|
|US4610656 *||Aug 21, 1984||Sep 9, 1986||Mehealus Partnership||Fully portable semi-automatic mechanical heart-lung substitution system and method|
|US4643713 *||Nov 5, 1984||Feb 17, 1987||Baxter Travenol Laboratories, Inc.||Venous reservoir|
|US4704203 *||Jun 9, 1986||Nov 3, 1987||Reed Charles C||Cardiotomy reservoir apparatus and method|
|US4717377 *||Aug 15, 1986||Jan 5, 1988||Terumo Kabushiki Kaisha||Blood circulating circuit for membrane-type artificial lung, and reservoir for use in blood circulating circuit|
|US4765959 *||Nov 12, 1985||Aug 23, 1988||Terumo Kabushiki Kaisha||Blood circulating circuit for membrane-type artificial lung, and reservoir for use in blood circulating circuit|
|US4832689 *||Nov 2, 1987||May 23, 1989||B. Braun Melsungen Ag||Infusion means|
|US5232439 *||Nov 2, 1992||Aug 3, 1993||Infusion Technologies Corporation||Method for pumping fluid from a flexible, variable geometry reservoir|
|US5342313 *||Nov 2, 1992||Aug 30, 1994||Infusion Technologies Corporation||Fluid pump for a flexible, variable geometry reservoir|
|US5578267 *||Aug 4, 1995||Nov 26, 1996||Minntech Corporation||Cylindrical blood heater/oxygenator|
|US5693039 *||Feb 2, 1994||Dec 2, 1997||Cobe Laboratories, Inc.||Venous reservoir bag assembly|
|US5720741 *||Jun 7, 1995||Feb 24, 1998||Cobe Laboratories, Inc.||Venous reservoir bag assembly|
|US5770073 *||Mar 15, 1996||Jun 23, 1998||Minntech Corporation||Combined cardiotomy and venous reservoir|
|US5931646 *||Oct 3, 1996||Aug 3, 1999||Terumo Kabushiki Kaisha||Blood delivery instrument for regulating the amount of blood stored in an accumulator independent of the pumping operation|
|US6106776 *||Apr 11, 1997||Aug 22, 2000||University Of Pittsburgh||Membrane apparatus with enhanced mass transfer via active mixing|
|US6113575 *||May 14, 1998||Sep 5, 2000||Terumo Cardiovascular Systems Corporation||Volume control apparatus for a flexible venous reservoir|
|US6123519 *||Apr 8, 1998||Sep 26, 2000||Terumo Kabushiki Kaisha||Delivery blood storing member-equipped blood reservoir tank and blood delivery instrument for extracorporeal circulation circuit|
|US6217826||Sep 21, 1998||Apr 17, 2001||University Of Pittsburgh||Membrane apparatus with enhanced mass transfer, heat transfer and pumping capabilities via active mixing|
|US6337049||Aug 28, 1998||Jan 8, 2002||Yehuda Tamari||Soft shell venous reservoir|
|US6348175||Oct 5, 1999||Feb 19, 2002||University Of Pittsburgh||Membrane apparatus with enhanced mass transfer via active mixing|
|US6723284||Nov 6, 2000||Apr 20, 2004||University Of Pittsburgh||Membrane apparatus with enhanced mass transfer, heat transfer and pumping capabilities via active mixing|
|US6773426||Feb 28, 2001||Aug 10, 2004||Yehuda Tamari||Soft shell venous reservoir with improved air handling|
|US7122151||Apr 19, 2004||Oct 17, 2006||University Of Pittsburgh||Membrane apparatus with enhanced mass transfer, heat transfer and pumping capabilities via active mixing|
|US7651473 *||Dec 8, 2004||Jan 26, 2010||Jms Co., Ltd.||Extracorporeal blood circulating apparatus, closed-type venous reservoir and extracorporeal blood circulating method|
|US20040219061 *||Apr 19, 2004||Nov 4, 2004||University Of Pittsburgh|
|DE3247149A1 *||Dec 21, 1982||Jul 5, 1984||Norbert Kraemer||Vorrichtung zur ueberwachung des blutstandes in einem oxygenator|
|DE102005029682A1 *||Jun 21, 2005||Dec 28, 2006||Maquet Cardiopulmonary Ag||Heart/lung bypass, for patients on a heart/lung machine, has a reservoir for priming solution and/or blood|
|EP0080610A1 *||Nov 5, 1982||Jun 8, 1983||Terumo Kabushiki Kaisha||Blood circulating circuit for membrane-type artificial lung, and reservoir for use in blood circulating circuit|
|EP0089748A2 *||Feb 21, 1983||Sep 28, 1983||CD Medical, Inc.||Rigid shell expansible blood reservoir, heater and hollow fibre membrane oxygenator assembly|
|EP0766974A2 *||Oct 2, 1996||Apr 9, 1997||Terumo Kabushiki Kaisha||Blood reservoir, blood delivery instrument, and blood delivery apparatus|
|WO1985003879A1 *||Jan 25, 1985||Sep 12, 1985||Omnis Surgical Inc||Priming system for ultrafiltration unit|
|WO1986001416A1 *||Aug 12, 1985||Mar 13, 1986||Mehealus Partnership||Fully portable semi-automatic mechanical heart-lung substitution system and method|
|WO2003018088A1 *||Aug 20, 2002||Mar 6, 2003||Michigan Critical Care Consult||Apparatus for exchanging gases in a liquid|
|U.S. Classification||422/46, 417/43, 417/37, 417/36, 422/111, 422/48, 417/250, 128/DIG.300|
|Cooperative Classification||Y10S128/03, A61M1/3639|