|Publication number||US3915151 A|
|Publication date||Oct 28, 1975|
|Filing date||Mar 25, 1974|
|Priority date||Mar 23, 1973|
|Also published as||DE2314573A1, DE2314573C2|
|Publication number||US 3915151 A, US 3915151A, US-A-3915151, US3915151 A, US3915151A|
|Original Assignee||Werner Kraus|
|Export Citation||BiBTeX, EndNote, RefMan|
|Patent Citations (4), Referenced by (181), Classifications (19)|
|External Links: USPTO, USPTO Assignment, Espacenet|
 Inventor: Werner Kraus, 31 Bauerstrasse,
Munich, Germany  Filed: Mar. 25, 1974  Appl. No.: 454,557
 Foreign Application Priority Data Mar. 23, 1973 Germany 2314573  US. Cl. l28/l.5; 128/82.l; 128/419 F; 128/419 R  Int. Cl. A61N 1/42  Field of Search 128/1.5, 404, 405, 411, 128/419 PF, 419 R, 420 A, 421, 422, 423, 82.1, 1 C
 References Cited UNITED STATES PATENTS 2,368,207 l/1945 Eaton 128/422 2,404,283 7/1946 Gieringer 128/405 3,490,458 1/1970 Allison 128/421 3,648,708 3/1972 Hoeri 128/422 FOREIGN PATENTS OR APPLICATIONS 871,672 6/1961 United Kingdom 128/420 United States Patent 1191 [111 3,915,151
Kraus Oct. 28, 1975 1 APPARATUS FOR PROMOTING HEALING 2,116,869 10/1971 Germany 128/82.1
PROCESSES 1,109,280 6/1961 Germany 128/420 OTHER PUBLICATIONS Cochran, Bulletin of the New York Academy of Medicine" Vol. 48, No. 7, Aug. 1972, pp. 89991 1.
Primary Examiner-William E. Kamm Attorney, Agent, or FirmSpencer & Kaye  ABSTRACT An apparatus for promoting healing of body tissue composed of a coil arranged to be applied to the affected body part and to be connected to a low frequency a.c. source to produce a magnetic field within the region to be treated, and at least two sheet-like electrodes associated with the coil and spaced from one another, the electrodes being arranged to be located at respectively opposite sides of the region to be treated and to be connected to a source of a low frequency voltage to produce an electric field within the region to be treated at the same time as the magnetic field.
5 Claims, 7 Drawing Figures FUNCTION. GENERATOR FOR ELECTRIC AND MAGNETIC FIELDS FUNCTION GENERATOR FOR ELECTRIC AND MAGNETIC FIELDS FIG.2
FUNCTION GENERATORX US. Patent Oct. 28, 1975 Sheet 2 of3 3,915,151
FUNCTION GENERATOR U.S. Patent Oct.28, 1975 Sheet 3-of3 3,915,151
PREAMPLI FIER VOLTAGE AMPLIFIER mm F APPARATUS FOR PROMOTING HEALING PROCESSES BACKGROUND OF THE INVENTION The present invention relates to an apparatus for promoting healing processes of the type including a coil adapted to be applied to a part of the body to be treated and which is adapted to be connected with a source for a varying current with a low frequency and makes it possible to produce a corresponding magnetic field, which pervades the part of the body to be treated.
The German Pat. Specification (Patentschrift) No. 1,918,299, corresponding to my US. Pat. No. 3,745,995, and the German Patent Specification (Offenlegungsschrift) No. 2,1 15,869, corresponding to my pending US. application Ser. No. 241,727, filed April 6, 1972, and also the Munchner Medizinische Wochenschrift 42 (1972), pages 1814 to 1819 refer to the promotion of healing of fractured bones by a low frequency AC pervading the injured bone zone galvanically. The AC has preferably a frequency below 100 Hz and a curve form Without steep leading and trailing flanks.
The AC prevading the injured bone Zone can be induced by an implanted receiving coil, provided with corresponding electrodes, using a magnetic field, which is produced by a coil which is applied to the part of the body to be treated and is connected with a suitable AC generator.
Furthermore, the above-mentioned German Pat. Specification No. 2,1 16,869 refers to the fact that the influence of a suitably directed low frequency magnetic alternating field alone leads to an encouragement of healing processes and to enhanced vascularisation (formation of blood vessels).
SUMMARY OF THE INVENTION One aim of the present invention is that of creating an apparatus which makes possible a still more pronounced encouragement of healing processes than the above-mentioned forms of apparatus.
This aim is to be achieved in accordance with the invention by an apparatus of the above-mentioned type which is characterised in that the coil is provided with two sheetlike electrodes which are arranged with a spacing between them and are adapted to be connected with a source of low frequency varying voltage for the production of an electric field which pervades the part of the body to be treated simultaneously with the magnetic field.
It has thus been found that the regeneration of damaged bone and soft tissue can be substantially promoted by the simultaneous application of slowly varying electricl and magnetic fields, preferably with approximately the same strength.
The sheet-like electrodes are electrically insulated from the part of the body to be treated or are so arranged at a distance from it that through the body part to be treated there flows no galvanic conduction current and instead only the displacement and polarisation current flows through the part of the body, this current being produced by the electric field between the sheetlike electrodes arranged like the plates of a capacitor.
Further developments and forms of the invention are defined in the subordinate claims.
An important feature of the invention resides in that the electric and magnetic fields, preferably having approximately the same energy content, vary with the same frequency but are shifted in phase relative to each other, the phase shift being approximately about In what follows, embodiments of the invention will be described with reference to the accompanying drawings.
BRIEF DESCRIPTION OF THE DRAWINGS FIG. 1 is a diagrammatic representation of an apparatus in accordance with a first embodiment of the invention, which is especially suitable for treating extremities of the human body.
FIG. 2 is a diagrammatic representation of a second embodiment of the invention.
FIG. 3a is a diagrammatic view of a third embodiment of the invention.
FIG. 3b shows an enlarged cross-section through a marrow pin belonging to the apparatus in accordance with FIG. 3a.
FIG. 4 shows a view similar to FIG. 3a of a further embodiment of the invention.
FIGS. 5 and 6 show partly sectioned views of further embodiments of the invention.
DESCRIPTION OF THE PREFERRED EMBODIMENTS The embodiment of the invention shown in FIG. 1 comprises a substantially cylindrical coil 10 (solenoid coil), which can be slid over the extremity, for example a leg 12 indicated in broken lines, to be treated. On the inner wall of the coil 10, on opposite sides, two electrodes 14 are arranged, which each consist for example of a thin metal sheet material, and are provided with insulation, not shown, which prevents galvanic or conductive contact between the electrodes 14 and the leg 12 to be treated, or another part of the body. The coil 10 and the electrodes 14 are connected respectively with wires 16, only indicated diagrammatically, leading to an electrical function generator 18, which supplies a current for the supply of the coil 10 and a voltage for supply of the electrodes 14.
The current supplied to the coil 10 can be a symmetrical or asymmetrical AC or DC withsuperimposed AC components or it can be a pulsating current. The frequency of the AC or of the AC component of the coil current produced by the function generator 18 is preferably adjustable and lies in the range of 1 to Hz for example and preferably between approximately 5 and 30 Hz. The oscillation form of the AC or AC com ponent respectively is preferably relatively low in harmonies (for example less than 20% or 10% harmonics). The leading and trailing flanks of the AC half cycles should not be abrupt and instead should be gradual. Therefore, in contrast to a sinusoidal or triangular wave current a square wave current is undesired.
The function generator preferably comprises means for producing current characteristics or functions which are copied from physiological variations in the human body, for example the course of the movement of the ribs during breathing, the pressure characteristic or function in the lungs or the course of the pulse wave form, and more particularly the systol or a healthy, normal person.
Much the same applies for the voltage which is supplied by the function generator 18 to the electrodes 14.
Electrical circuit arrangments for the supply of voltages and currents of a complicated wave form are described in the book Waveforms Radiation Laboratory Series, McGRaw-Hill, New York, 1949 for example. Voltage and current functions copied from physiological functions can be produced for example by using suitably constructed sensors applied to the body and using amplifier circuits for the supply of the coils and electrodes respectively with the required current strength or voltage respectively. Finally, also signals of the desired shape can be stored on a loop of magnetic tape, which is then played back with a suitable speed and the played back signals are amplified in the manner required for supply of the coil and the electrodes respectively.
The amplitudes of the AC current and voltage are preferably adjustable and preferably have such values that the energy content of the magnetic field pervading the part of the body treated and the energy content of the electric field simultaneously pervading the treatd part of the body are at least approximately the same. The magnetic field strength in tissue can lie for example between 20 and 200 Gauss, while the electrical field strength for the treatment of tissue regions close to the electrodes can amount to approximately 0.1 V/cm to approximately 1 V/cm. For the treatment of deeper regions or parts of the body it is also possible to operate with substantially higher field strengths.
The function generator 18 can comprise setting members for simultaneous and independent variation of the amplitudes of the AC voltage and of the AC current.
Preferably the function generator 18 furthermore comprises a device which makes it possible to adjust the phase position between the AC current and the AC voltage. Preferably the AC current and the AC voltagbe and, respectively, the AC current and the AC voltage components of the current supply to the coil and of the voltage applied to the electrodes 14 have a phase shift of approximately 90.
The coil 10 and the electrodes 14 associated with it are preferably so constructed that the magnetic field lines diagrammatically shown are substantially parallel to the principal direction of the flow of blood in the part of the body treated or, respectively, in the longitudinal direction of an extremity being treated. The electrical fields should, on the other hand, be approximately perpendicular to the magnetic fields and therefore be generally perpendicular to the physiological orientation, for example the direction of the fibers in the bone.
The device or apparatus in accordance with FIG. 1 is especially suitable for encouraging the healing of closed bone fractures, in the case of which the repositioning fixation of the parts of the fractured bone in relation to each other) is not carried out by an operation and instead is brought about by external fixing with plaster. In the case of such fractures the duration of healing and therefore the danger of atrophic interference, more particularly in the case of older persons, can be substantially reduced.
FIG. 2 shows an embodiment of the invention with a magnetic coil arrangement 10, which comprises a number of flat coils 10a to 10f, which can be regarded as flattened cylinder coils and are connected, at their longitudinal edges running parallel to the axis of coiling,- with each other in a jointed manner so that they can be applied for example externally to the torso or head and then produce an axial magnetic field in the respective part of the body. The flat coils 10a to 10f are connected electrically in series and are connected with a function generator 18, as has been explained with reference to FIG. 1.
The side, facing in a certain direction, of each flat coil 10a to 10f carries a corresponding plate-like electrode 14a to 14f, whose surface is provided with insulation coating which is not shown.
The electrodes, arranged on the flat coils 10a to 100, are connected with a lead connected with the function generator 18, while the other lead connected with the function generator 18 is connected with the electrodes of the flat coil 10d to 10f. The electric and magnetic field distribution occurring in this embodiment of the invention is shown in FIG. 2 the magnetic field lines being represented by long broken lines and the electric field lines being represented by short broken lines.
FIG. 3a shows in section a fractured bone 20, which has been reset by means of a marrow nail 22. The marrow nail 22 comprises a receiving coil 24 (FIG. 3b) of a rodshaped ferrite core, on which a solenoid winding is arranged. In contrast to the above-mentioned known electro marrow nails the ends of the receiving coil 24 are, however, not connected with the electrodes on the surface of the marrow nail, which are in galvanic contact with the bone to be healed, and instead are connected with electrodes 14, whose surfaces are insulated, so that no galvanic currents can flow between them. The electrodes 14 can be embedded for example in the marrow nail, which at least for this part consists of a dielectric material.
The marrow nail 22 described is mounted as is conventional in the injured bone 20 and the injured extremity comprising the marrow nail 22 with the receiving coil 24 is then brought into the field of a coil 10 placed over the injured extremity. The coil 10 is connected with a function generator 18 of the type described with reference to FIG. 1. The voltage induced by the magnetic field of the coil 10in the receiving coil 24 passes to the insulated electrodes 14' so that in the bone zone an electrical field is produced which runs generally perpendicularly to the magnetic field. The coil 10 can, as has been explained with reference to FIG. 1, additionally be provided with electrodes 14, which are directly supplied with a voltage by the function generator 18 and this voltage preferably has the same frequency as the AC in the coil 10, but with respect to this voltage is shifted in amplitude by approximately In the case of the apparatus in accordance with FIG. 3 it is naturally also the magnetic field of the receiving coil 24 which is effective, which can therefore be regarded as an equivalent to the coil 10.
The apparatus in accordance with FIG. 4 is similiarly constructed to the apparatus in accordance with FIG. 3a and for components equivalent in function the same reference numerals have been used. In the case of FIG. 4 the fractured bone 20 is, however, not pinned or nailed and instead, since it is a question of a closed fracture, it is fixed by a plaster cast or the like. In the plaster, insulated field electrodes 14 are embedded and are connected by flexible electrical leads with the function generator. Another possibility resides in providing windows in a plaster or plastic cast and fixing the field electrodes in the windows acting as frames adjacent to the surface of the extremity to be treated so that the electrodes are separated by an air gap from the surface of the patient. The coil and the electrodes 14 are supplied by a function generator 18 with a low frequency current or a low frequency voltage. The function generator 18' is synchronised or controlled in the case of this embodiment by means of a pulse receiving means 30, that is to say in the latter case the course of the AC or of the AC voltage corresponds to the pulse pressure wave. he function generator 18' can as an altemative measure also be synchronised by an electrocardiogram or controlled with respect to the curve shape.
In the case of the apparatus in accordance with FIG. 4 the pulse receiving means can for example be a pressure sensor or a very low frequency microphone M and the function generator 18 can comprise the following circuit units: A pre-amplifier, whose input is connected with the pulse receiving means 30 and whose output is connected on the one hand directly with the input of a current amplifier and on the other hand is connected with an adjustable phase shifting device for connection with the input of a voltage amplifier. The output of the current amplifier supplies the magnet coil 10, while the output of the voltage amplifier is connected with the electrodes 14 it being understood that in practice there are two output leads from the voltage amplifier rather than the one shown.
FIGS. 5 and 6 show two embodiments of the present device, which comprise a pin-like body 32 with rounded ends, which can consist of a fluorine carbon polymer for example. In the body there is a substantially cylindrical shaped receiving coil 24 which can comprise a rod-shaped magnetic core which is not especially shown.
The ends of the receiving coil are connected respectively with two electrodes, which are embedded in the body 32. Preferably the surface of each electrode is insulated so that no galvanic currents can flow from it. The electrodes 24a of the embodiment in accordance with FIG. 5 have the shape of parts of the cylindrical casing and are arranged on opposite sides of the body 32. The electrodes 14b of the embodiment in accordance with FIG. 6 are annular and arranged on the body 32 with an axial spacing.
The embodiment in accordance with FIGS. 5 and 6 can be mounted in the marrow channel of a bone, for example in the case of osteomyelitis, and furthermore they are suitable for producing autologous replacement of fibers by growing round or encapsulation.
The present apparatus is particularly suitable for encouraging healing processes in and under closed skin, that is to say in the case of closed fractures and also in the case of pathological processes in tissue. The polarisation force of the electrical field has a substantial influence on the recovery of the structure of the damaged tissue, while the distribution of blood vessels within the structure is directly influenced by the magnetic field. Owing to the combination of electrical and magnetic fields the essential conditions for regeneration of a functioning structure, that is to say healing, are provided.
A further possiblity of influencing the biological processes in the tissues is based in the fact that the magnetic and/or electrical alternating field, more particularly the latter, can have DC components superimposed on it, which may possibly be so large that no reversal of polarity of the field occurs and instead a pulsating field with a predetermined polarity comes into play. In
this case the function generator 18 or 18' respectively can comprise circuitry features which make it possible to superimpose on the AC supplied to the coil 10 DC preferably with adjustable amplitude and if necessary adjustable polarity and/or make it possible to superimpose on the AC voltage supplied to the electrodes 14 a DC voltage, preferably with an adjustable amplitude and polarity.
The preferred phase shift between electrical and magnetic fields can, however, also be produced by a delay member, possibly adjustable, in the function generator or also by a differentiating member, which derives AC voltage from AC supplied to the coil 10, and whose course or shape corresponds to the differential with respect to time of the AC current. The use of a differentiating member for the production of the desired phase shift between the magnetic and electrical fields is particularly suitable in the case of the use of nonsinusoidal current or voltage shapes or characteristics, for example when the course of the fields is to be adapted to a biological magnitude, for example the pulse pressure wave or systole.
What I claim is:
1. In apparatus for promoting healing processes and comprising a coil adapted to be applied to a part of the body to be treated and adapted to be connected with a source for a varying current with a low frequency for causing the coil to produce a corresponding magnetic field in the longitudinal direction of and which pervades the part of the body to be treated, the improvement comprising two sheet-like electrodes associated with said coil, disposed with a spacing between them and arranged to be connected with a source of low frequency varying voltage of producing an electric field which pervades the part of the body to be treated simultaneously with the magnetic field, said electrodes extending at least approximately parallel to the surface occupied by the windings of the coil.
2. An apparatus in accordance with claim 1 wherein the coil is composed of a number of flat coils connected to each other in a jointed manner, with at least two of said coils being provided with a respective one of said sheet-like electrodes.
3. An apparatus in accordance with claim 1 further comprising a rod-shaped body of a tissue-compatible insulating material, and a receiving coil carried by said body, and wherein said two electrodes are electrically connected to said receiving coil and extend adjacent to the surface of said body.
4. An apparatus in accordance with claim 3 wherein said electrodes are provided with an insulating surface.
5. In apparatus for promoting healing processes and comprising a coil adapted to be applied to a part of the body to be treated and adapted to be connected with a source for a varying current with a low frequency for causing the coil to produce a corresponding magnetic field, which pervades the part of the body to be treated, the improvement comprising two insulated sheet-like electrodes, disposed with a spacing between them and arranged to be connected with a source of low frequency varying voltage for producing an electric field which pervades the part of the body to be treated simultaneously with the magnetic field, a bone splint implantate member; a receiving coil arranged on such implantate member and magnetically linked to said firstrecited coil, said receiving coil having terminals each connected to a respective one of said two insulated sheet-like electrodes and constituting said source of voltage.
|Cited Patent||Filing date||Publication date||Applicant||Title|
|US2368207 *||Jan 30, 1941||Jan 30, 1945||Warren S Eaton||Method of and means for therapeutic treatment|
|US2404283 *||Jan 17, 1942||Jul 16, 1946||Licbel Flarsheim Company||Electrode for diathermy treatments|
|US3490458 *||Jan 14, 1964||Jan 20, 1970||Donald K Allison||Electrotherapy device with synchronized pulses and sounds|
|US3648708 *||Jun 23, 1969||Mar 14, 1972||Mehdi Haeri||Electrical therapeutic device|
|Citing Patent||Filing date||Publication date||Applicant||Title|
|US4056097 *||Mar 15, 1976||Nov 1, 1977||Joachim Adolf Maass||Contactless stimulus transducer|
|US4066065 *||May 24, 1976||Jan 3, 1978||Werner Kraus||Coil structure for electromagnetic therapy|
|US4095588 *||Jul 19, 1976||Jun 20, 1978||Joseph Goldman||Vascular cleansing|
|US4105017 *||Nov 17, 1976||Aug 8, 1978||Electro-Biology, Inc.||Modification of the growth repair and maintenance behavior of living tissue and cells by a specific and selective change in electrical environment|
|US4154246 *||Jul 25, 1977||May 15, 1979||Leveen Harry H||Field intensification in radio frequency thermotherapy|
|US4186729 *||Nov 25, 1977||Feb 5, 1980||Donald L. Morton & Associates||Deep heating electrode|
|US4230129 *||Apr 22, 1976||Oct 28, 1980||Leveen Harry H||Radio frequency, electromagnetic radiation device having orbital mount|
|US4233965 *||Jan 16, 1978||Nov 18, 1980||Cas Products, Inc.||Method and apparatus for the therapeutic treatment of living tissue|
|US4266532 *||Mar 17, 1978||May 12, 1981||Electro-Biology, Inc.||Modification of the growth, repair and maintenance behavior of living tissues and cells by a specific and selective change in electrical environment|
|US4266533 *||Apr 9, 1979||May 12, 1981||Electro-Biology, Inc.||Modification of the growth, repair and maintenance behavior of living tissues and cells by a specific and selective change in electrical environment|
|US4292980 *||Oct 31, 1979||Oct 6, 1981||Hakuju Institute For Health Science Co., Ltd.||Electrode assembly for use in electric field therapy apparatus|
|US4306564 *||Sep 25, 1978||Dec 22, 1981||Werner Kraus||Electrification attachment for an osteo-synthesis implantate|
|US4307726 *||Sep 4, 1979||Dec 29, 1981||Paulson James C||Diagnostic evaluation, measurement, and analysis of functional activity in body organs that utilize transmembrane ion polarization and depolarization|
|US4315503 *||Dec 5, 1979||Feb 16, 1982||Electro-Biology, Inc.||Modification of the growth, repair and maintenance behavior of living tissues and cells by a specific and selective change in electrical environment|
|US4421115 *||Dec 8, 1980||Dec 20, 1983||Werner Kraus||Electrification attachment for an osteosynthesis implantate|
|US4549547 *||Jul 27, 1982||Oct 29, 1985||Trustees Of The University Of Pennsylvania||Implantable bone growth stimulator|
|US4556051 *||Nov 5, 1982||Dec 3, 1985||Empi, Inc.||Method and apparatus for healing tissue|
|US4616629 *||May 24, 1985||Oct 14, 1986||Electro-Biology, Inc.||Coil construction for electromagnetic treatment of an afflicted body region|
|US4641633 *||Apr 25, 1985||Feb 10, 1987||Delgado Jose M R||Electronic system for the activation, inhibition and/or modification of the development and functioning of cells, organs and organisms of living beings|
|US4662884 *||Apr 25, 1984||May 5, 1987||University Of Utah Research Foundation||Prostheses and methods for promoting nerve regeneration|
|US4674482 *||Mar 17, 1986||Jun 23, 1987||Irt, Inc.||Pulse electro-magnetic field therapy device with auto bias circuit|
|US4757804 *||Aug 25, 1986||Jul 19, 1988||Lti Biomedical, Inc.||Device for electromagnetic treatment of living tissue|
|US4765310 *||Oct 29, 1986||Aug 23, 1988||Dynatens Research Corporation||Electrical and magnetic pain treatment device|
|US4778467 *||Jul 10, 1986||Oct 18, 1988||The University Of Utah||Prostheses and methods for promoting nerve regeneration and for inhibiting the formation of neuromas|
|US4838850 *||May 7, 1987||Jun 13, 1989||Henning Rosengart||Electromedical treatment apparatus|
|US4846178 *||May 11, 1987||Jul 11, 1989||Beijing Information Technology Institute||Electric field therapeutic apparatus|
|US4937323 *||Jun 13, 1988||Jun 26, 1990||University Of Medicine And Dentistry Of New Jersey||Method and apparatus for lidc enhanced wound healing using biocompatible tissue ingrowth implants|
|US4940453 *||Jan 28, 1987||Jul 10, 1990||Cadwell Industries, Inc.||Method and apparatus for magnetically stimulating neurons|
|US5038780 *||Apr 29, 1988||Aug 13, 1991||The Biotronics Research Corp.||Method and apparatus for capacitively regenerating tissue and bone|
|US5047005 *||Jul 5, 1990||Sep 10, 1991||Cadwell Industries, Inc.||Method and apparatus for magnetically stimulating neurons|
|US5052997 *||Apr 10, 1987||Oct 1, 1991||The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services||Diathermy coil|
|US5103806 *||Jul 31, 1990||Apr 14, 1992||The Research Foundation Of State University Of New York||Method for the promotion of growth, ingrowth and healing of bone tissue and the prevention of osteopenia by mechanical loading of the bone tissue|
|US5116304 *||May 10, 1991||May 26, 1992||Cadwell Industries, Inc.||Magnetic stimulator with skullcap-shaped coil|
|US5131904 *||May 4, 1990||Jul 21, 1992||Richard Markoll||Treatment of arthritis with magnetic field therapy and apparatus therefor|
|US5170784 *||Nov 27, 1990||Dec 15, 1992||Ceon Ramon||Leadless magnetic cardiac pacemaker|
|US5267939 *||Oct 10, 1991||Dec 7, 1993||Life Resonances, Inc.||Techniques for controlling osteoporosis using non-invasive magnetic fields|
|US5324314 *||Mar 23, 1992||Jun 28, 1994||Boetzkes Peter C||Method and apparatus for capacitively regenerating tissue and bone|
|US5390672 *||Oct 8, 1993||Feb 21, 1995||Board Of Regents Univ. Of Nebraska||NMR liver coil|
|US5415617 *||Jan 21, 1993||May 16, 1995||Kraus; Werner||Applicator coil for magnetic field therapy|
|US5435302 *||Sep 22, 1993||Jul 25, 1995||Medrad, Inc.||Flexible surface coils for use in nuclear magnetic resonance imaging|
|US5441527 *||Jan 24, 1994||Aug 15, 1995||Amei Technologies Inc.||Implantable bone growth stimulator and method of operation|
|US5453073 *||Feb 28, 1994||Sep 26, 1995||Bio Magnetic Therapy Sys Inc||Apparatus for treatment of diseased body organs with magnetic field therapy|
|US5518495 *||Aug 29, 1994||May 21, 1996||Magnetherapy, Inc.||Magnetic field therapy apparatus|
|US5524624 *||May 5, 1994||Jun 11, 1996||Amei Technologies Inc.||Apparatus and method for stimulating tissue growth with ultrasound|
|US5527259 *||Jul 5, 1994||Jun 18, 1996||Circuitry Systems Limited||Magnetic field induction multi-pulse therapy|
|US5565005 *||Feb 17, 1993||Oct 15, 1996||Amei Technologies Inc.||Implantable growth tissue stimulator and method operation|
|US5665049 *||Feb 3, 1995||Sep 9, 1997||Bio-Magnetic Field Therapy Systems Inc.||Treatment of acute diseases as caused by the sports-type injuries of the musculoskeletal system (excluding fractures) with magnetic field therapy|
|US5669868 *||Mar 22, 1996||Sep 23, 1997||Bio-Magnetic Therapy Systems||Treatment of wrinkled discolored or aging skin with magnetic field therapy|
|US5741253 *||Oct 29, 1992||Apr 21, 1998||Michelson; Gary Karlin||Method for inserting spinal implants|
|US5766231 *||Oct 11, 1996||Jun 16, 1998||Neomedics, Inc.||Implantable growth tissue stimulator and method of operation|
|US5772661 *||Feb 27, 1995||Jun 30, 1998||Michelson; Gary Karlin||Methods and instrumentation for the surgical correction of human thoracic and lumbar spinal disease from the antero-lateral aspect of the spine|
|US5792209 *||Apr 1, 1996||Aug 11, 1998||Varner; Lawrence Norman||Osteoporosis-relief device|
|US5797909 *||Jun 7, 1995||Aug 25, 1998||Michelson; Gary Karlin||Apparatus for inserting spinal implants|
|US5842966 *||Apr 11, 1995||Dec 1, 1998||Bio-Magnetic Therapy Systems, Inc.||Treatment of arthritis with magnetic field therapy|
|US5880661 *||Apr 1, 1996||Mar 9, 1999||Emf Therapeutics, Inc.||Complex magnetic field generating device|
|US6007476 *||Oct 22, 1997||Dec 28, 1999||Emf Therapeutics, Inc.||Non-particle, non-photonic device and method for affecting angiogenesis|
|US6034295 *||Dec 2, 1996||Mar 7, 2000||Christoph Rehberg||Implantable device having an internal electrode for stimulating growth of tissue|
|US6083149 *||Jul 8, 1998||Jul 4, 2000||Emf Therapeutics, Inc.||Magnetic field device and method for inhibiting angiogenesis and retarding growth rates of tumors in mammals|
|US6096038 *||Jun 7, 1995||Aug 1, 2000||Michelson; Gary Karlin||Apparatus for inserting spinal implants|
|US6119631 *||Apr 1, 1999||Sep 19, 2000||Markoll; Richard||Coil cabinet for treating animals with magnetic field therapy|
|US6123705 *||Oct 1, 1996||Sep 26, 2000||Sdgi Holdings, Inc.||Interbody spinal fusion implants|
|US6149577 *||Mar 18, 1999||Nov 21, 2000||Emf Therapeutics, Inc.||Apparatus and method for creating a substantially contained, finite magnetic field useful for relieving the symptoms pain and discomfort associated with degenerative diseases and disorders in mammals|
|US6149650 *||May 8, 1998||Nov 21, 2000||Michelson; Gary Karlin||Threaded spinal implant|
|US6200259 *||Jun 3, 1999||Mar 13, 2001||Keith L. March||Method of treating cardiovascular disease by angiogenesis|
|US6210412||Jun 7, 1995||Apr 3, 2001||Gary Karlin Michelson||Method for inserting frusto-conical interbody spinal fusion implants|
|US6224595||Apr 20, 1998||May 1, 2001||Sofamor Danek Holdings, Inc.||Method for inserting a spinal implant|
|US6264656||May 8, 1998||Jul 24, 2001||Gary Karlin Michelson||Threaded spinal implant|
|US6270498||Jun 7, 1995||Aug 7, 2001||Gary Karlin Michelson||Apparatus for inserting spinal implants|
|US6275996||Jan 28, 2000||Aug 21, 2001||Acushnet Company||Articles with removable elements|
|US6317630 *||Jan 29, 1999||Nov 13, 2001||Yossi Gross||Drug delivery device|
|US6334069||Jan 15, 1999||Dec 25, 2001||Regenesis Biomedical, Inc.||Pulsed electromagnetic energy treatment apparatus and method|
|US6353763||Jun 27, 2000||Mar 5, 2002||Regenesis Biomedical, Inc.||Pulsed electromagnetic energy treatment apparatus and method|
|US6364824||Nov 11, 1999||Apr 2, 2002||Orthofix, Inc.||Stimulating cell receptor activity using electromagnetic fields|
|US6463323||Nov 12, 1999||Oct 8, 2002||Em Vascular, Inc.||Electrically mediated angiogenesis|
|US6556872||Dec 5, 2000||Apr 29, 2003||Ev Vascular, Inc.||Therapeutic device and method for treating diseases of cardiac muscle|
|US6560489||Jan 8, 2001||May 6, 2003||Em Vascular, Inc.||Therapeutic device and method for treating diseases of cardiac muscle|
|US6561968 *||Aug 29, 2000||May 13, 2003||Biofields Aps||Method and an apparatus for stimulating/ modulating biochemical processes using pulsed electromagnetic fields|
|US6592509 *||Feb 4, 2002||Jul 15, 2003||Thomas W. Hunter, Jr.||Electromagnetic stimulator|
|US6605089||Sep 23, 1999||Aug 12, 2003||Gary Karlin Michelson||Apparatus and method for the delivery of electrical current for interbody spinal arthrodesis|
|US6611962||Jun 26, 2001||Sep 2, 2003||Acushnet Company||Articles with removable elements|
|US6620117||Jan 20, 2000||Sep 16, 2003||Connextech, L.L.C.||Vibrational device for stimulating tissue and organs|
|US6758849||Aug 18, 2000||Jul 6, 2004||Sdgi Holdings, Inc.||Interbody spinal fusion implants|
|US6770074||Nov 17, 2001||Aug 3, 2004||Gary Karlin Michelson||Apparatus for use in inserting spinal implants|
|US6875213||Feb 21, 2003||Apr 5, 2005||Sdgi Holdings, Inc.||Method of inserting spinal implants with the use of imaging|
|US6923810||Jun 7, 1995||Aug 2, 2005||Gary Karlin Michelson||Frusto-conical interbody spinal fusion implants|
|US6978173 *||Oct 31, 2001||Dec 20, 2005||Biotronik Mess- Und Therapiegeraete Gmbh & Co.||Device for influencing cell-growth mechanisms in vessels of a human or animal body|
|US7024239||Nov 20, 2001||Apr 4, 2006||Regenesis Biomedical, Inc.||Pulsed electromagnetic energy treatment apparatus and method|
|US7135022 *||May 22, 2002||Nov 14, 2006||Orthogon 2003 Ltd.||Magnetically-actuable intramedullary device|
|US7207991||Mar 18, 2002||Apr 24, 2007||Warsaw Orthopedic, Inc.||Method for the endoscopic correction of spinal disease|
|US7264622||Oct 24, 2003||Sep 4, 2007||Warsaw Orthopedic, Inc.||System for radial bone displacement|
|US7291149||Oct 4, 1999||Nov 6, 2007||Warsaw Orthopedic, Inc.||Method for inserting interbody spinal fusion implants|
|US7326214||Aug 9, 2003||Feb 5, 2008||Warsaw Orthopedic, Inc.||Bone cutting device having a cutting edge with a non-extending center|
|US7361136||May 27, 2005||Apr 22, 2008||Parker Richard F||Method and apparatus for generating a therapeutic magnetic field|
|US7399303||Aug 20, 2002||Jul 15, 2008||Warsaw Orthopedic, Inc.||Bone cutting device and method for use thereof|
|US7431722||Jun 6, 2000||Oct 7, 2008||Warsaw Orthopedic, Inc.||Apparatus including a guard member having a passage with a non-circular cross section for providing protected access to the spine|
|US7452359||Jun 7, 1995||Nov 18, 2008||Warsaw Orthopedic, Inc.||Apparatus for inserting spinal implants|
|US7455672||Jul 31, 2003||Nov 25, 2008||Gary Karlin Michelson||Method for the delivery of electrical current to promote bone growth between adjacent bone masses|
|US7491205||Jun 7, 1995||Feb 17, 2009||Warsaw Orthopedic, Inc.||Instrumentation for the surgical correction of human thoracic and lumbar spinal disease from the lateral aspect of the spine|
|US7534254||Jun 7, 1995||May 19, 2009||Warsaw Orthopedic, Inc.||Threaded frusto-conical interbody spinal fusion implants|
|US7569054||Nov 8, 2005||Aug 4, 2009||Warsaw Orthopedic, Inc.||Tubular member having a passage and opposed bone contacting extensions|
|US7686805||Jul 1, 2004||Mar 30, 2010||Warsaw Orthopedic, Inc.||Methods for distraction of a disc space|
|US7691148||Mar 19, 2005||Apr 6, 2010||Warsaw Orthopedic, Inc.||Frusto-conical spinal implant|
|US7722619||Apr 25, 2006||May 25, 2010||Warsaw Orthopedic, Inc.||Method of maintaining distraction of a spinal disc space|
|US7753915 *||Jun 14, 2007||Jul 13, 2010||August Eksler||Bi-directional bone length adjustment system|
|US7828800||May 18, 2009||Nov 9, 2010||Warsaw Orthopedic, Inc.||Threaded frusto-conical interbody spinal fusion implants|
|US7887565||Feb 18, 2006||Feb 15, 2011||Warsaw Orthopedic, Inc.||Apparatus and method for sequential distraction|
|US7914530||Apr 25, 2006||Mar 29, 2011||Warsaw Orthopedic, Inc.||Tissue dilator and method for performing a spinal procedure|
|US7935116||Nov 25, 2008||May 3, 2011||Gary Karlin Michelson||Implant for the delivery of electrical current to promote bone growth between adjacent bone masses|
|US7942933||Apr 3, 2010||May 17, 2011||Warsaw Orthopedic, Inc.||Frusto-conical spinal implant|
|US7993347||Jul 27, 2000||Aug 9, 2011||Warsaw Orthopedic, Inc.||Guard for use in performing human interbody spinal surgery|
|US8057475||Nov 9, 2010||Nov 15, 2011||Warsaw Orthopedic, Inc.||Threaded interbody spinal fusion implant|
|US8066705||Feb 21, 2003||Nov 29, 2011||Warsaw Orthopedic, Inc.||Instrumentation for the endoscopic correction of spinal disease|
|US8170684 *||Mar 23, 2010||May 1, 2012||Novocure Limited||Electrodes for applying an electric field in-vivo over an extended period of time|
|US8206387 *||Apr 21, 2011||Jun 26, 2012||Michelson Gary K||Interbody spinal implant inductively coupled to an external power supply|
|US8226652||Nov 14, 2011||Jul 24, 2012||Warsaw Orthopedic, Inc.||Threaded frusto-conical spinal implants|
|US8251997||Nov 29, 2011||Aug 28, 2012||Warsaw Orthopedic, Inc.||Method for inserting an artificial implant between two adjacent vertebrae along a coronal plane|
|US8353909||Apr 25, 2006||Jan 15, 2013||Warsaw Orthopedic, Inc.||Surgical instrument for distracting a spinal disc space|
|US8409292||May 17, 2011||Apr 2, 2013||Warsaw Orthopedic, Inc.||Spinal fusion implant|
|US8439915 *||Feb 22, 2007||May 14, 2013||The Regents Of The University Of California||Apparatus and methods for magnetic alteration of anatomical features|
|US8602960||Dec 2, 2010||Dec 10, 2013||Stanley Kolt||K-Ring electromagnetic treatment apparatus, system and method for tumors, arthritis and other ailments|
|US8679118||Jul 23, 2012||Mar 25, 2014||Warsaw Orthopedic, Inc.||Spinal implants|
|US8734447||Jun 27, 2000||May 27, 2014||Warsaw Orthopedic, Inc.||Apparatus and method of inserting spinal implants|
|US8758344||Aug 28, 2012||Jun 24, 2014||Warsaw Orthopedic, Inc.||Spinal implant and instruments|
|US9265794 *||Aug 26, 2014||Feb 23, 2016||Rutgers, The State University Of New Jersey||Insulin-mimetics as therapeutic adjuncts for bone regeneration|
|US9320913||Apr 16, 2015||Apr 26, 2016||Rio Grande Neurosciences, Inc.||Two-part pulsed electromagnetic field applicator for application of therapeutic energy|
|US9415233||Feb 3, 2014||Aug 16, 2016||Rio Grande Neurosciences, Inc.||Apparatus and method for electromagnetic treatment of neurological pain|
|US9427598||Oct 3, 2011||Aug 30, 2016||Rio Grande Neurosciences, Inc.||Method and apparatus for electromagnetic treatment of head, cerebral and neural injury in animals and humans|
|US9433797||Feb 3, 2014||Sep 6, 2016||Rio Grande Neurosciences, Inc.||Apparatus and method for electromagnetic treatment of neurodegenerative conditions|
|US9440089||Feb 3, 2014||Sep 13, 2016||Rio Grande Neurosciences, Inc.||Apparatus and method for electromagnetic treatment of neurological injury or condition caused by a stroke|
|US9656096 *||Oct 31, 2011||May 23, 2017||Rio Grande Neurosciences, Inc.||Method and apparatus for electromagnetic enhancement of biochemical signaling pathways for therapeutics and prophylaxis in plants, animals and humans|
|US20010052764 *||Jan 26, 2001||Dec 20, 2001||Werner Siekmann||Magnetic-field device for stimulating and/or supporting physical functions|
|US20020138100 *||Oct 31, 2001||Sep 26, 2002||Biotronik Mess-Und Therapiegeraete Gmbh & Co.||Device for influencing cell-growth mechanisms in vessels of a human or animal body|
|US20040138663 *||May 22, 2002||Jul 15, 2004||Yona Kosashvili||Magnetically-actuable intramedullary device|
|US20050059153 *||Jan 16, 2004||Mar 17, 2005||George Frank R.||Electromagnetic activation of gene expression and cell growth|
|US20050267355 *||May 27, 2005||Dec 1, 2005||Parker Richard F||Method and apparatus for generating a therapeutic magetic field|
|US20060129189 *||Jan 30, 2006||Jun 15, 2006||Regenesis Biomedical, Inc.||Pulsed electromagnetic energy treatment apparatus and method|
|US20060187607 *||May 27, 2003||Aug 24, 2006||Seung-Kee Mo||Apparatus and method for creating pulse magnetic stimulation having modulation function|
|US20060241333 *||Apr 21, 2006||Oct 26, 2006||Ksm, Inc.||Electromagnetic treatment device|
|US20060276845 *||Aug 11, 2006||Dec 7, 2006||Regenesis Biomedical, Inc.||Pulsed electromagnetic energy treatment apparatus and method|
|US20070078292 *||Oct 5, 2005||Apr 5, 2007||Electromagnetic Resources, Inc.||Electromagnetic fields for systemic effect in therapy|
|US20070150035 *||Feb 12, 2007||Jun 28, 2007||Kiril Pandelisev||Multiple Selectable Field/Current-Voltage Pads Having Individually Powered and Controlled Cells|
|US20070260106 *||Nov 10, 2006||Nov 8, 2007||Ksm, Inc.||Constant amplitude electromagnetic system for Treating An Animal Using A Constant Amplitude Electromagnetic Device|
|US20070260136 *||Nov 10, 2006||Nov 8, 2007||Ksm, Inc.||Method For Conducting Double-Blind Testing Using A Constant Amplitude Electromagnetic System|
|US20070276378 *||Feb 22, 2007||Nov 29, 2007||The Regents Of The University Of California||Apparatus and methods for magnetic alteration of anatomical features|
|US20080097141 *||Oct 19, 2006||Apr 24, 2008||Stanley Kolt||K-ring electromagnetic treatment apparatus, system and method for tumors, arthritis and other ailments|
|US20100099942 *||Oct 20, 2008||Apr 22, 2010||Lucas Portelli||Method and apparatus for electromagnetic human and animal immune stimulation and/or repair systems activation|
|US20100179621 *||Mar 23, 2010||Jul 15, 2010||Yoram Palti||Electrodes for applying an electric field in-vivo over an extended period of time|
|US20100298886 *||Dec 3, 2008||Nov 25, 2010||Neue Magnetodyn Gmbh||Contact Device for Osteosynthesis|
|US20110015698 *||Sep 24, 2010||Jan 20, 2011||Regenesis Biomedical, Inc.||Pulsed electromagnetic energy treatment apparatus and method|
|US20110077452 *||Dec 2, 2010||Mar 31, 2011||Stanley Kolt||K-ring electromagnetic treatment apparatus, system and method for tumors, arthritis and other ailments|
|US20110196501 *||Apr 21, 2011||Aug 11, 2011||Gary Karlin Michelson||Interbody spinal implant inductively coupled to an external power supply|
|US20120089201 *||Oct 31, 2011||Apr 12, 2012||Pilla Arthur A||Method and apparatus for electromagnetic enhancement of biochemical signaling pathways for therapeutics and prophylaxis in plants, animals and humans|
|US20130261682 *||May 10, 2013||Oct 3, 2013||Ellipse Technologies, Inc.||Bone growth device and method|
|US20130310824 *||Jul 18, 2013||Nov 21, 2013||Mohammadreza Meymanat||System for detecting, actively targeting and selectively treating malignant cells in human body by non-invasive procedure|
|US20150010499 *||Aug 26, 2014||Jan 8, 2015||Rutgers, The State University Of New Jersey||Insulin-mimetics as therapeutic adjuncts for bone regeneration|
|US20160317827 *||May 10, 2016||Nov 3, 2016||Btl Holdings Limited||Combination of radiofrequency and magnetic treatment methods|
|CN103323799A *||May 14, 2012||Sep 25, 2013||东方先进技术开发股份有限公司||Spiral magnetic field generator|
|CN104203342A *||Mar 21, 2013||Dec 10, 2014||波格丹·康斯坦丁·维拉迪拉||Apparatus for local application of an extremely low frequency magnetic field to cells|
|CN104203342B *||Mar 21, 2013||Jun 1, 2016||波格丹·康斯坦丁·维拉迪拉||用于对细胞局部应用极低频磁场的装置|
|EP0042889A1 *||Jun 26, 1980||Jan 6, 1982||Electro-Biology, Inc||Electromagnetic body-treatment device|
|EP0126805A1 *||Jun 26, 1980||Dec 5, 1984||Electro-Biology, Inc||Electromagnetic body-treatment device|
|EP0181053A2 *||May 28, 1985||May 14, 1986||Irt, Inc.||Pulse electro-magnetic field therapy device with auto biased circuit and method for use|
|EP0181053A3 *||May 28, 1985||Jul 20, 1988||Irt, Inc.||Pulse electro-magnetic field therapy device with auto biased circuit and method for use|
|EP0189620A1 *||Jan 29, 1985||Aug 6, 1986||Empi, Inc.||Method and apparatus for healing tissue|
|EP0342813A2 *||May 2, 1989||Nov 23, 1989||Biotronics Research Corp.||Method and apparatus for capacitively regenerating tissue and bone|
|EP0342813A3 *||May 2, 1989||Feb 12, 1992||Biotronics Research Corp.||Method and apparatus for capacitively regenerating tissue and bone|
|EP0857494A2 *||May 6, 1991||Aug 12, 1998||Bio-Magnetic Therapy Systems, Inc.||Apparatus for treating a body organ with magnetic field therapy|
|EP0857494A3 *||May 6, 1991||Apr 21, 1999||Bio-Magnetic Therapy Systems, Inc.||Apparatus for treating a body organ with magnetic field therapy|
|EP1170032A1||Aug 28, 2000||Jan 9, 2002||Med-Tech A/S||Magnetic field generator for an electromedical treatment apparatus|
|EP1371388A3 *||May 6, 1991||Aug 11, 2004||Bio-Magnetic Therapy Systems, Inc.||Apparatus for treating a body organ with magnetic field|
|WO1981002833A1 *||Dec 1, 1980||Oct 15, 1981||M Kalfaian||Field radiator for curing cancer and other ailments|
|WO1982001135A1 *||Oct 3, 1980||Apr 15, 1982||H Rosengart||Electromedical treatment apparatus|
|WO1991016941A1 *||May 6, 1991||Nov 14, 1991||Bio Magnetic Therapy Sys Inc||Magnetic field therapy and apparatus|
|WO1995032673A1 *||May 26, 1995||Dec 7, 1995||Michelson Gary K||Apparatus and method, delivery of electrical current|
|WO2000027295A1 *||Nov 11, 1999||May 18, 2000||Orthofix, Inc.||Stimulating cell receptor activity using electromagnetic fields|
|WO2002004072A1||Jul 2, 2001||Jan 17, 2002||Med-Tech A/S||Magnetic generator for an electromedical treatment apparatus|
|WO2012093277A3 *||Oct 25, 2011||Nov 1, 2012||Vladila Bogdan Constantin||Electro-magnetic cellular treatment|
|WO2012106306A2 *||Jan 31, 2012||Aug 9, 2012||Advanced Magnet Lab, Inc.||Systems and methods which remove material from blood vessel walls|
|WO2012106306A3 *||Jan 31, 2012||Nov 1, 2012||Advanced Magnet Lab, Inc.||Systems and methods which remove material from blood vessel walls|
|WO2013139915A1 *||Mar 21, 2013||Sep 26, 2013||Bogdan Constantin Vladila||Apparatus for local application of an extremely low frequency magnetic field to cells|
|WO2014143684A1 *||Mar 14, 2014||Sep 18, 2014||Prezacor, Inc.||Therapeutic bioelectromagnetic fields|
|U.S. Classification||600/13, 607/3, 607/51|
|International Classification||A61N2/00, A61N1/40, A61N1/32, A61B17/56, A61N2/04, A61B17/58|
|Cooperative Classification||A61B17/58, A61N2/002, A61N2/02, A61N2/004, A61N1/40|
|European Classification||A61N2/00T, A61N2/02, A61N1/40, A61N2/00C, A61B17/58|