|Publication number||US3918452 A|
|Publication date||Nov 11, 1975|
|Filing date||Aug 1, 1974|
|Priority date||Aug 1, 1974|
|Publication number||US 3918452 A, US 3918452A, US-A-3918452, US3918452 A, US3918452A|
|Original Assignee||Cornfeld Edward|
|Export Citation||BiBTeX, EndNote, RefMan|
|Patent Citations (12), Referenced by (68), Classifications (13), Legal Events (2)|
|External Links: USPTO, USPTO Assignment, Espacenet|
United States Patent 1191 Cornfeld [451 Nov. 11, 1975 [5 1 TAMPONS IMPREGNATED WITH 3.108.043 10/1963 Somerville 128/270 I CONTRACEPTIVE COMPOSITIONS 3.108043 10/1963 Mi11man 128/270 X 3,424,159 1/1969 Whitehead at 211.... 128/263 1 Inventorl Edward Potomac, 3.490.454 1/1970 G01df2ll'b et a1 128/285 3.521637 7/1970 Waterbury 1 128/270  Asslgnee' ai S'lver Spnng 3.639562 2/1972 Gordon et Z11..... 128/270 x 3,679,102 7/1972 Charle 1 1 128/260 X  i Aug 1 974 3,749,094 7/1973 Duncan 128/270 3,756,238 9/1973 Hanke.... 128/270  Appl. No: 493,831 3,850,173 11/1974 Dash 128/261 152 US. Cl. 128/270; 128/260; 128/263 i' Medbery 424/16 Attorney, Agent, or Firm-Sherman & Shalloway  Int. Cl. A61F 13/20; A61K 7/00  Field of Search 128/260, 270, 285, 290 R,  ABSTRACT 261; 424/16 45 Vaginal sponges and/or tampons impregnated with contraceptive compositions and methods of prevent-  References Clted ing conception or implantation by insertion in an ani- UNITED STATES PATENTS mal organism of said sponge or tampon prior to expo- 702,570 6/1902 Lohlein 128/263 sure to conception. 2,943,979 7/1960 Elias 424/16 3.091.241 5/1963 K6116 128/270 3 Clams, 5 Drawlng Figures US. Patent Nov. 11, 1975 FIG.4
TAMPONS IMPREGNATED WITH CONTRACEPTIVE COMPOSITIONS BACKGROUND OF THE INVENTION DESCRIPTION OF THE PRIOR ART It has long been an object of the pharmaceutical industry to discover a safe and'effective method of preventing conception which can be utilized precoitus that is non-interfering and easy to use.
Heretofore, it has been known to impregnate tampons with an abortive facient, such as pi'ostaglandin, in order to terminate a conception in the very early states of the pregnancy.
Additionally, prior art methods are known for preventing conception by utilization of vaginal foams or creams containing cont'faceptive compositions. The prior art means of preventing conception are either inconvenient to use or have physiological or psychological drawbacks once pregnancy has begun.
U.S. Pat. No. 3,105,128 shows a method of microencapsulation.
U.S. Pat. No. 3,691,271 shows a sanitary napkin with microcapsules filled with a bactericidal and fungicidal deodorant.
U.S. Pat. No. 3,814,809 shows the combination of a suppository and tampon with a contraceptive drug for use after exposure.
I SUMMARY OF THE PRESENT INVENTION It is a general feature of the present invention to avoid and overcome the foregoing and other difficulties and objections to prior art contraceptive means by the provision of a more effective and generally acceptable means. More specifically, a feature of the present invention is to provide a vaginal sponge or tampon which is impregnated with a known safe and effective contra ceptive composition.
Further, another feature of the present invention is to provide a vaginal sponge or tampon which is impregnated with a contraceptive drug that is microencapsulated so that there is a sustained release of the contraceptive composition before, during and/or after coitus.
It is still another feature of the present invention to provide a means for insertion of the sponge or tampon into the vagina which can be packaged as a single unit.
A yet further feature of the present invention is to provide a means for housing the impregnated sponge or tampon, inserting the sponge or tampon and, if desired, removing the sponge or tampon from the vagina.
The aforesaid features of the present invention, and other features which will become apparent as the description proceeds, are accomplished by providing a vaginal sponge or tampon that is impregnatedupreferably 'a microencaptlital eenrrlce snve cameos:
' sules which maybe used are those which provide a sustained release and/or those which are pressure rupturable. The contraceptive composition may include any of the known steroidal or non-steroidal compounds.
A method having certain features of this invention includesthe step of inserting and maintaining in the vagina a sponge or tampon impregnated with a contraceptive composition, preferably a composition which is microencapsulated.
DETAILED DESCRIPTION OF THE PRESENT INVENTION For a better understanding of the present invention, reference should be made to the accompanying drawings,. wherein like numerals indicate similar parts throughout the several views and wherein:
FIG. 1 isa perspective view of a tampon and applicator inaccordance with this invention. I
FIG. 2 isa perspective view of a further applicator and tampon of the present invention.
FIG. 3 is a perspective view of a tampon of this invention. p
FIG. 4 is a cross-sectional view of the impregnated tampon of FIG. 3
FIG. 5 is a cross-sectional view of an impregnated sponge having aspring means.
PREFERRED EMBODIMENTS OF THE PRESENT I INVENTION able in the housing 12 so as to eject the tampon 14 from the housing 12. If the tampon 14 is provided with a means for removal, such as a string 19, the housing 12 may be provided with'a slot 18 so as to accommodate the string. V
FIG. 2 illustrates a further embodiment of the invention wherein there is provided an applicator 20 having a housing 28 containing an impregnatedtampon 24 in the front end portion. The applicator 20 is provided with a plunger 26 which ejects the tampon 24 and is capable of providing a vacuum suction so as to withdraw the tampon when desired. x
FIG. 3 shows the tampon prior to compression and insertion into the applicator shown in FIG. 1. The tampon comprises any of the known cellulosic tampons that are well known in the art. The tampon includes those which contain the conventional polyurethane foams, the reaction product of liquid polyols (polyester or polyether) and a disfunctional isocyanate, usually toluene diisocyanate. A catalyst such as tin, an ammine, a flowing agent, generally water, and foaming stabilizers are also employed. The required cylinders for tampon use are cut from the prepared foam. The string 19 is provided for removal of the tampon either preor post-coitus FIG. 4 is a cross-sectional view of the tampon of FIG. 3 showing the microencapsulations 40 The microcapsules used in the present: invention uahrbe madeabf any Beaver-newly mplayea material in :the mieroefic apwanna new; -Represenmive of polymeric mataria-ls to prcs'anee- @He--mi@f6capsules aresuellz polymfli's an polymyimeehol, pdlyerh ylene, polypropylene. polystyrilefpolyatrylamidesg polyethers; pdlyestehs; polyamides, polybutadiene, polyisoprene, epoxy resins, polyurethanes, ethyl cellulose, carboxymethyl cellulose and the like. The nature and the size of the walls will be generally chosen for their compatibility with the contraceptive composition used. Generally, the ratio of the weight of the wall to the total weight of the filled microcapsule ranges from between 3-10:100.
Any conventional technique of microcapsule fabrication can be used, particularly microencapsulation by mechanical means such as centrifugal microencapsulatioh. In this method, droplets of the material to be microencapsulated are formed by the centrifugal force of a turntable which then traverse by means of the velocity with which they thus acquire a thin film of fluid product designed to form the wall of the microcapsule. Conventional wall-hardening treatment can be employed which, in a case where the wall is prepared from a thermoplastic material, can simply be a sudden cooling of the microcapsules formed. Representative suitable microencapsulation operation can be found in the literature, for instance U.S. Pat. No. 3,015,128.
The material encapsulated in the microcapsules can be, for instance, such contraceptive compounds as nonylphenoxypolyethoxyethanol and an estrongenic compound such as 3-methoxy-19-nor-170z-pregna- 1,3,5( l)-trien-20-yn-17-o1; l9-nor-17oz-pregn-4-enyne-l3B, 17 diol and the like.
FIG. is a cross-sectional view of a vaginal sponge 50 which comprises preferably a cellular resilient material 52 having therein a spring 54 for maintaining the sponge in an expanded state. The sponge 52 may comprise any of the known water-resistant cellular matter such as cellulosic sponge, polyurethane, polyesters, and the like which are compatible with the body. The sponge 50 contains throughout the microcapsules 40 containing the contraceptive material. The size and composition of the capsule wall is preferably varied in solubility and rupturability so as to provide a sustained release during usage. Additionally, the microcapsules may contain in addition to the contraceptive compositions any spermicide which is known in the art. The microencapsulation permits the utilization of known compatible compositions simultaneously.
The method in accordance with this invention comprises inserting in the animal organism one vaginal tampon which is impregnated with a contraceptive composition and/or spermicidal composition between one hour and twenty-four hours prior to exposure. As stated above, the contraceptive has a sustained release in the vagina during and after coitus so that any exteriorally inserted fluids, such as semen resulting from coitus, will be exposed to the contraceptive compositions and any accompanying spermicide released by the rupturability and solubility of the micro capsules 40 in the normal muscosa fluid present in the vagina.
Obviously, the dosage form will depend upon the contraceptive composition employed, besides that the microcapsules generally have a size ranging from about 50 1,000 microns in diameter. The thickness of the wall of the microcapsule will vary according to the materials used and to the effect desired,
The microcapsules are introduced either directly into the sponge or tampon at a moment-in which its fluidity porate them before termination of the polymerization of the sponge.
In general, microcapsules are introduced into the sponge or tampon in the course of manufacture in the form of a liquid or suspension; the best possible homogenization is obtained by suitable mixing by agitation, shaking or blowing in of a gas. The density of the liquid or of the suspension is then adjusted to that of the microcapsules by addition of a suitable inert substance. It is also possible to select microcapsules whose density corresponds to that of the liquid or suspension at the time of their introduction into the sponge or tampon. The following non-limiting examples, in which parts and percentages refer to weight, are given by way of illustration and allow a fuller understanding of the present invention.
EXAMPLE 1 Tampon containing a microencapsulated contraceptive composition:
The following contraceptive composition is prepared:
Contraceptive Compound 4.0 Vaseline 6.0 Glycerol 10.0 Anti-ferment 0.1 Water to make-up 100.0
The contraceptive composition is then microencapsulated by the known technique, using polypropylene, the microcapsules having an average diameter of 50-100 microns and preferably 60-80 microns. Microcapsules are dispersed either by a suitable mechanical device or by projection using compressed air or gas.
The contraceptive compound may be any of the known estrogenic agents such as Enovid (Trademark).
EXAMPLE 11 The sponge containing microencapsulated contraceptive composition:
The following solution is prepared:
Glycerin 5.00 Contraceptive Compound 10.00 Oxytoxin 0.50
EXAMPLE 111 The following composition is prepared:
Spermicide 10.00 Gl yrine 10.00 Sodium Lauryl SulfateSolution (30%) 30.00
This composition containing-- the spermicide; is thh microencapsulated utilizing p e lyyiay l 'a uhalfiay any positions, the vaginal sponge or tampon may be surface coated or impregnated with a contraceptive composition dissolved or suspended in a melt of a low-melting, biodegradable wax. The 'wax with the contraceptive compound incorporated is then either powdered or the melt is poured over a cold surface and a waxy material scraped off in the forms of powder or flakes. Among the vehicles for slow release of the contraceptive composition in biological fluids are acetyl palmitate, carbona wax, lauric acid, a mixture of sodium laurate and lauric acid, a mixture of stearic acid and sodium stearate, a mixture of archidonic acid and sodium archidonate and acetyl palmitate.
Obviously, the embodiments shown are exemplary only and a wide variety of embodiments may be devised without departing from the spirit and scope of the invention.
What is claimed is:
l. The method of preventing conception or implantation which comprises inserting into the vagina of a mammal a sponge tampon impregnated with microcapsules having a contraceptive composition prior to exposure to exteriorally inserted fluids and permitting said sponge tampon to remain in the vagina until at least an effective amount of said composition is released and leaving the sponge tampon in the vagina at least during the insertion of said exterior fluids so as to prevent conception or implantation from said fluids.
2. The method of claim 1 wherein said comosition is microencapsulated in a sustained release form and said composition is caused to be released by the biological muscosa fluid.
3. The method of claim 1 wherein said microcapsules include a spermicide and said spermicide is released with said contraceptive composition.
|Cited Patent||Filing date||Publication date||Applicant||Title|
|US702570 *||Aug 1, 1901||Jun 17, 1902||Leonard J Lohlein||Combined applicator and syringe.|
|US2943979 *||Jun 23, 1959||Jul 5, 1960||Nathaniel M Elias||Concentrated foam-producing spermicides|
|US3091241 *||Aug 26, 1959||May 28, 1963||Kimberly Clark Co||Vaginal tampon|
|US3108043 *||May 9, 1960||Oct 22, 1963||Ortho Pharma Corp||Spermicidal sheet-like material|
|US3424159 *||Dec 12, 1966||Jan 28, 1969||Kimberly Clark Co||Tampon insertion device|
|US3490454 *||Oct 21, 1966||Jan 20, 1970||United Merchants & Mfg||Catamenial products having a coating of rupturable microcapsules containing medicants|
|US3521637 *||Nov 28, 1967||Jul 28, 1970||Haskett Barry F||Tampon or similar sanitary napkin containing vitamin a|
|US3639562 *||Apr 29, 1970||Feb 1, 1972||Smith Kline French Lab||Vaginal suppositories and impregnated tampons|
|US3679102 *||Feb 4, 1970||Jul 25, 1972||Oreal||Aerosol composition and method for producing same|
|US3749094 *||Aug 18, 1971||Jul 31, 1973||Procter & Gamble||Tampon with string attached to its proximal end|
|US3756238 *||Mar 24, 1971||Sep 4, 1973||Kimberly Clark Co||Self-lubricating compound for use in hygienic and medical applications, and coated tampons and suppositories made therefrom|
|US3850173 *||Apr 30, 1973||Nov 26, 1974||American Home Prod||Flushable vaginal applicator|
|Citing Patent||Filing date||Publication date||Applicant||Title|
|US4186742 *||Jun 9, 1978||Feb 5, 1980||Donald Enterprises, Inc.||Contraceptive-antivenereal disease tampon|
|US4271835 *||May 17, 1978||Jun 9, 1981||Kcdp Corporation||Fluid-expansible contraceptive tampon and applicator|
|US4309997 *||Mar 24, 1980||Jan 12, 1982||Donald Jack W||Contraceptive and/or antivenereal disease tampon|
|US4318405 *||Jul 24, 1980||Mar 9, 1982||Sneider Vincent R||Tampon and drug delivery device|
|US4351338 *||May 21, 1980||Sep 28, 1982||Pierre Langlois||Vaginal tampon|
|US4393871 *||Mar 30, 1981||Jul 19, 1983||Vli Corporation||Vaginal device|
|US4553965 *||Jul 6, 1984||Nov 19, 1985||Shepard Conn||Fluid-expansible contraceptive tampon and applicator|
|US4585651 *||Dec 18, 1980||Apr 29, 1986||Stolle Research & Development Corporation||Active/passive immunization of the internal female reproductive organs|
|US4618496 *||Jul 16, 1984||Oct 21, 1986||Johnson & Johnson||Antimicrobial peat moss composition|
|US4645488 *||Nov 30, 1983||Feb 24, 1987||Board Of Trustees Of The University Of Alabama||Syringe for extrusion of wetted, particulate material|
|US4732763 *||Sep 28, 1984||Mar 22, 1988||Stolle Research And Development Corporation||Active/passive immunization of the internal female reproductive organs|
|US4742820 *||Sep 17, 1985||May 10, 1988||Hannegret Leuchtenberger||Device for introducing a diaphragm|
|US5141515 *||Oct 11, 1990||Aug 25, 1992||Eberbach Mark A||Apparatus and methods for repairing hernias|
|US5304187 *||Jun 30, 1992||Apr 19, 1994||United States Surgical Corporation||Surgical element deployment apparatus|
|US5366460 *||Aug 24, 1992||Nov 22, 1994||Cook Incorporated||Apparatus and method for laparoscope hernia repair|
|US5520669 *||Jul 19, 1994||May 28, 1996||Mulholland; Kevin J.||Intra-rectal drain and receptacle for fecal incontinence|
|US5527534 *||Oct 21, 1993||Jun 18, 1996||Gynetech Laboratories, Ltd.||Vaginal sponge delivery system|
|US5741239 *||May 24, 1996||Apr 21, 1998||Mulholland; Kevin J.||Intra-rectal drain and receptacle for fecal incontinence|
|US6558362 *||Feb 2, 2000||May 6, 2003||Bernard Chaffringeon||Disposable device for transferring an active liquid into a body cavity|
|US6645136||Sep 28, 2000||Nov 11, 2003||Kimberly-Clark Worldwide, Inc.||Incontinence insert applicators and methods for their use|
|US6676594||Sep 18, 2002||Jan 13, 2004||Kimberly-Clark Worldwide, Inc.||C-shaped vaginal incontinence insert|
|US6695763||Jan 2, 2002||Feb 24, 2004||Kimberly-Clark Worldwide, Inc.||Incontinence insert device and method of using same|
|US6758840||Apr 20, 2001||Jul 6, 2004||Metris Therapeutics Limited||Drug delivery device|
|US6770025||Sep 18, 2002||Aug 3, 2004||Kimberly-Clark Worldwide, Inc.||Molar shaped vaginal incontinence insert|
|US6808485||Dec 23, 2002||Oct 26, 2004||Kimberly-Clark Worldwide, Inc.||Compressible resilient incontinence insert|
|US6939289||Oct 21, 2002||Sep 6, 2005||Kimberly-Clark Worldwide, Inc.||Ellipitcal applicator system|
|US7004171||Feb 25, 2002||Feb 28, 2006||Hi-Gienic Intra Vaginal Technologies Ltd.||System for transvaginal drug delivery|
|US7044928||Apr 4, 2003||May 16, 2006||Platex Products, Inc.||Tampon applicator assembly having an improved plunger and methods of making|
|US7091395 *||Jun 2, 2003||Aug 15, 2006||Jean-Bastien Pasquini||Antiseptic tampon and method of preparing it|
|US7128925||Feb 2, 2001||Oct 31, 2006||3X Engineering||Device for applying active principles for pharmaceutical or cosmetic purposes|
|US7186248 *||Aug 16, 2002||Mar 6, 2007||Peter James Brian Lamb||Device for introducing an object into a vagina with sanitary finger mounting means|
|US7527614||Mar 25, 2005||May 5, 2009||Kimberly-Clark Worldwide, Inc.||Protective tube for a medicated tampon|
|US7708726||Apr 28, 2005||May 4, 2010||Kimberly-Clark Worldwide, Inc.||Dosage form cap for an applicator|
|US7744556||Mar 25, 2005||Jun 29, 2010||Kimberly-Clark Worldwide, Inc.||Delivery tube assembly for an applicator|
|US7815593||Jan 12, 2007||Oct 19, 2010||Peter James Brian Lamb||Device for introducing an object into a vagina with sanitary finger mounting means|
|US7846171||May 27, 2004||Dec 7, 2010||C.R. Bard, Inc.||Method and apparatus for delivering a prosthetic fabric into a patient|
|US7919453||Mar 25, 2005||Apr 5, 2011||Kimberly-Clark Worldwide, Inc.||Dosage cap assembly for an applicator|
|US7993667||Mar 25, 2005||Aug 9, 2011||Kimberly-Clark Worldwide, Inc.||Methods of manufacturing a medicated tampon assembly|
|US8137327||Jun 16, 2006||Mar 20, 2012||Family Health International||Vaginal drug delivery system and method|
|US8221440||Nov 8, 2010||Jul 17, 2012||C.R. Bard, Inc.||Method and apparatus for delivering a prosthetic fabric into a patient|
|US8388996||Aug 8, 2011||Mar 5, 2013||Kimberly-Clark Worldwide, Inc.||Methods of manufacturing a medicated tampon assembly|
|US9272070 *||Mar 5, 2014||Mar 1, 2016||Microcapsules Technologies||Absorbent article|
|US20030153864 *||Oct 15, 2002||Aug 14, 2003||Bernard Chaffringeon||Disposable device and method for transferring an active liquid into a body cavity|
|US20030163103 *||Feb 25, 2002||Aug 28, 2003||Simon Benita||System for transvaginal drug delivery|
|US20030191439 *||Mar 28, 2003||Oct 9, 2003||Bernard Chaffringeon||Disposable device for transferring an active liquid into a body cavity|
|US20040050402 *||Feb 2, 2001||Mar 18, 2004||D'auria Stanislas Boulet||Device for applying active principles for pharmaceutical or cosmetic purposes|
|US20040077924 *||Oct 21, 2002||Apr 22, 2004||Kimberly-Clark Worldwide, Inc.||Ellipitcal applicator system|
|US20040078013 *||Oct 21, 2002||Apr 22, 2004||Kimberly-Clark Worldwide, Inc.||Lubricated incontinence device applicator|
|US20040199100 *||Apr 4, 2003||Oct 7, 2004||Playtex Products, Inc.||Tampon applicator assembly having an improved plunger and methods of making|
|US20040236265 *||Aug 16, 2002||Nov 25, 2004||Lamb Peter James Brian||Device for introducing an object into a vagina|
|US20050187507 *||Jan 6, 2005||Aug 25, 2005||Reed Andre' L.||Method and apparatus for removal of menses, reduction of menses interference during coitus, and enhancement of sexual pleasure|
|US20070255232 *||Jun 18, 2007||Nov 1, 2007||Bernard Chaffringeon||Disposable device and method for transferring an active liquid into a body cavity|
|US20070293837 *||Jun 16, 2006||Dec 20, 2007||Sokal David C||Vaginal drug delivery system and method|
|US20130136784 *||Jan 23, 2013||May 30, 2013||Robert J. Staab||Methods for delivery of medication using dissolvable devices|
|US20140257217 *||Mar 5, 2014||Sep 11, 2014||Microcapsules Technologies||Absorbent article|
|USD492033||Apr 4, 2003||Jun 22, 2004||Playtex Products, Inc.||Tampon applicator assembly|
|USD746520 *||Apr 23, 2014||Dec 29, 2015||Mark L. Anderson||Applicator|
|EP0006861A1 *||Jan 16, 1979||Jan 23, 1980||Vorhauer Lab||Biologically compatible tampon sponge.|
|EP0006861A4 *||Jan 16, 1979||Sep 12, 1980||Vorhauer Lab||Biologically compatible tampon sponge.|
|EP0029708A1 *||Nov 20, 1980||Jun 3, 1981||Vorhauer Laboratories, Ltd.||Biologically compatible tampon contraceptive|
|EP0051709A1 *||Nov 7, 1980||May 19, 1982||Atlantic Pharmaceutical Products||Contraceptive tampon, set of a tampon and an applicator and process for preparing the tampon|
|EP2352544A2 *||Nov 9, 2009||Aug 10, 2011||Combinent Biomedical Systems, Inc.||Devices and methods for treating and/or preventing diseases|
|WO1980000008A1 *||May 24, 1979||Jan 10, 1980||Donald Enterprises Inc||Contraceptive-antivenereal disease tampon|
|WO1997043987A1 *||May 24, 1996||Nov 27, 1997||Mulholland Kevin J||Intra-rectal drain and receptacle for fecal incontinence|
|WO1998016207A1 *||Oct 8, 1997||Apr 23, 1998||3X Engineering||Micro-capsule support material|
|WO2001056540A2 *||Feb 2, 2001||Aug 9, 2001||3X Engineering||Device for applying active principles for pharmaceutical or cosmetic purposes|
|WO2001056540A3 *||Feb 2, 2001||Apr 4, 2002||3X Engineering||Device for applying active principles for pharmaceutical or cosmetic purposes|
|WO2011044707A1 *||Oct 13, 2010||Apr 21, 2011||Marlafin Ag||Applicator for inserting an elongated object into a human or animal body orifice|
|U.S. Classification||604/515, 604/11, 424/431, D24/141, 604/286, 424/433|
|International Classification||A61F13/26, A61F13/20, A61K9/00|
|Cooperative Classification||A61F13/26, A61K9/0036|
|European Classification||A61K9/00M8B, A61F13/26|
|Nov 29, 1983||AS02||Assignment of assignor's interest|
Owner name: CORNFIELD, EDWARD
Effective date: 19831107
Owner name: MEDICAL PHYSICS CORPORATION, 11212 VALLEY VIEW AVE
|Nov 29, 1983||AS||Assignment|
Owner name: MEDICAL PHYSICS CORPORATION, 11212 VALLEY VIEW AVE
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST.;ASSIGNOR:CORNFIELD, EDWARD;REEL/FRAME:004195/0117
Effective date: 19831107