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Publication numberUS3918461 A
Publication typeGrant
Publication dateNov 11, 1975
Filing dateJan 31, 1974
Priority dateJan 31, 1974
Publication numberUS 3918461 A, US 3918461A, US-A-3918461, US3918461 A, US3918461A
InventorsCooper Irving S
Original AssigneeCooper Irving S
Export CitationBiBTeX, EndNote, RefMan
External Links: USPTO, USPTO Assignment, Espacenet
Method for electrically stimulating the human brain
US 3918461 A
Abstract
A method and apparatus for electrically stimulating the human brain which includes applying electrodes directly to the cerebellum and feeding electrical impulses to such electrodes with a view to aiding individuals suffering from intractable hypertonia, epilepsy and other ailments, said electrical impulses having a duration of from 0.5 to 2.5 milliseconds, an ampliude of from 0.5 to 14.0 volts, and a frequency of from 1 to 300 pulses per second.
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Description  (OCR text may contain errors)

United States Patent [191 Cooper 1 [4 1 Nov. 11, 1975 METHOD FOR ELECTRICALLY STIMULATING THE HUMAN BRAIN Irving S. Cooper, 4422 Third Ave., Bronx, NY. 10457 Filed: Jan. 31, 1974 Appl. No.: 438,433

Inventor:

US. Cl 128/422; 128/420 Int. Cl. A61N 1/36 Field of Search 128/419 R, 420, 421, 422,

References Cited UNITED STATES PATENTS 10/1955 Shaw 3/1 5/1967 128/21 R 6/1969 Doyle 3/1 10/1972 Brindley et a1 128/419 R ELECTRODES RECEIVERS 3,735,756 5/1973 Richards et a1 128/421 OTHER PUBLICATIONS Smith et al., American Journal of Medical Electronics, Jan.-Mar., 1965, pp. 38-41.

Primary Examiner-William E. Kamm [5 7] ABSTRACT A method and apparatus for electrically stimulating the human brain which includes'applying electrodes directly to the cerebellum and feeding electrical impulses to such electrodes with a view to aiding individuals suffering from intractable hypertonia, epilepsy and other ailments, said electrical impulses having a duration of from 0.5 to 2.5 milliseconds, an ampliude of from 0.5 to 14.0 volts, and a frequency of from 1 to 300 pulses per second.

7 Claims, 3 Drawing Figures ANTENNA US. Patent Nov.1l, 1975 Sheet10f2 3,918,461

ELECTRODES ANTENNA RECEIVERS TRANSMITTER FIG.I

US. Patent Nov. 11, 1975 Sheet 2 of2 3,918,461

PIC-3.2

VgLTgGE KEYED C NT OLLED o OSCILLATOR MULTIVIBRATOR FREE RUNNING SYMMETRICAL MULTIVIBRATOR Z8NQ%JELLED KEYED o 'ONBSHOT OSCILLATOR MULTIVIBRATOR TRANSMITTER 2 Q TRIGGER RECEIVER 1 METHOD FOR ELECTRICALLY STIMULATING THE HUMAN BRAIN This invention pertains to a technique for electrically stimulating the human brain to alleviate certain disorders, and more particularly applying electrical impulses to the cerebellum of the brain.

There are substantial numbers of people who suffer from disorders such as intractable hypertonia, epilepsy and related ailments. Although drugs have been used to alleviate the symptoms of such ailments, there are unfortunately cases where the drugs are ineffective or must be used in such massive doses as to cause depression and drowsiness in the patient.

It is also possible to alleviate such symptoms in some cases by means of surgery. However, surgery involves the risk of an adverse outcome and is irreversible.

Accordingly, it is a general object of this invention to provide a technique to alleviate the symptoms of ailments such as hypertonia, epilepsy, stroke and the like.

Another object of this invention is to provide an improved technique for treating the symptoms of such ailments without recourse to massive doses of drugs or to irreversible surgery.

Briefly, the invention contemplates a method of treating particular human ailments by applying to the cerebellum electrical pulses having a specified range of frequencies, amplitudes and duration.

Other objects of this invention will be apparent from the following detailed description when read with the accompanying drawing, where:

FIG. I shows a schematic representation of apparatus for practicing the invention;

FIG. 2 is a block diagram of a transmitter; and

FIG. 3 is a block diagram of a receiver utilized in the invention.

The apparatus of the instant invention comprises two sets of electrodes implanted in the head of the patient; with each set being in direct contact with the neocerebellum and the paleocerebellum respectively. The electrodes 10 are connected via signal leads 12 to a pair of receivers 14 embedded in the chest of the patient, the signal leads being internal to the patient.

Opposite the implanted receivers 14 is an antenna 16 connected via an external signal lead 18 to an external transmitter 20. In operation, the transmitter 20 emits signals which are fed via signal lead 18 to antenna 16 which radiates the signals to the implanted receivers 14, which in turn transmit voltage pulses via implanted signal leads 12 to implanted electrodes 10 More specifically, the signals received by electrodes 10 are voltage pulses which stimulate the indicated portions of the cerebellum.

It has been found that voltage pulses which are rectangular in waveform and have durations of from 0.5 milliseconds to 2.5 milliseconds; and preferably, 1.0 milliseconds lead to good results when their amplitudes are between 0.5 and 14 volts.

The pulse repetition rate is a function of the ailment being treated. In the case of epilepsy, the pulse repetion rate should be of the order of 10.0 pulses per second with pulse amplitudes of 5.0 to 10.0 volts.

When treating hypertonia, the pulse repetition rate should be in the order of from l00 to 200 pulses per second with pulse amplitudes of 10.0 to 14.0 volts. Furthermore, it has been found in some cases of epilepsy, it is desirable to feed alternate bursts of pulses to the electrodes so that the paleocerebellum and neocerebellum are continuously, but alternately stimulated. It has been found that such bursts should have a duration of from about 1 minute to about 30 minutes, and preferably about 8 minutes.

In other cases, continuous stimulation may be indicated; while in other instances when the patient senses the onset of aura, stimulation is initiated.

Although the individual components of the system are well known in the electronic art; they will be discussed for the sake of completeness.

The transmitter 20 shown in FIG. 2 can be a twochannel transmitting device wherein each channel comprises a keyed oscillator, i.e. a sine wave oscillator of which when turned or keyed on, emits a packet of carrier signals. The oscillator each channel has a different carrier frequency. Each ofthe keyed oscillators can be driven by a voltage controlled one shot multivibrator, i.e. a multivibrator, which, as long as it receives a control voltage, emits, say 1.0 millisecond pulses having the desired repetition rate.

The voltage controlled one shot multivibrator can be controlled by a further symmetrical free running multivibrator or similarly functioning circuit with a pair of out of phase outputs, each being connected to one of the voltage controlled one shot multivibrators.

The symmetrical multivibrator is dimensioned to change state and consequently energize alternate outputs at the desired frequency, e.g. once every 8.0 minutes. Thus, it can be seen that the transmitter 20 feeds to antenna 16 1.0 millisecond packets of carrier signal wherein the carrier signal has a first frequency for all packets occuring during one 8.0 minute interval, and a second frequency for all packets occuring during the next 8.0 minute interval. Astable multivibrators with a period of 8.0 minutes, may also be used.

Antenna 16 can be fixed to the exterior of the patients chest by means of adhesive tape or the like; or, can be implanted subcutaneously, in which case, the transmitter 20 should be easily detachable from lead 18.

The receivers 14 shown in FIG. 3 can be identical except for operating frequency. Each receiver can comprise: a tuned amplifier tuned to either the first or second frequency; an envelope (conventional AM) detector connected to the output of the amplifier; and a Schmitt trigger circuit coupled to the output of the envelope detector for amplifying and squaring the output of the envelope detector.

Thus, each receiver alternately omits pulses which are fed via subcutaneous leads tunnelled from the anterior chest wall to the posterior fossa and then to their respective sets of electrodes 10 directly contacting the cerebellum.

The electrodes 10 are essentially 4 pairs of platinum disc electrodes on a silicon coated mesh of Dacron fiber or the like, applied to the neocerebellum and the paleocerebellum.

The details of the operation for positioning the electrodes with respect to the cerebellum, can be found in the article entitled Physiologic Neurosurgery at New Yorks St. Barnabas Hospital, pages 32-53 of Contemporary Surgery, Vol. 2, No. 6, June 1973, published by McGraw Hill.

Although a specific configuration of the transmitter, receiver and electrodes has been disclosed; it should be apparent that other devices which can generate the required waveforms for application directly to the cerebellum, can be used to treat a number of ailments.

Further, while the apparatus has been disclosed for alternate stimulation of the neocerebellum and paleocerebellum. it is possible to stimulate either region alone. or both regions simultaneously. In each case there is need for only a single channel transmitter and a single channel receiver.

1 claim:

1. A method of stimulating the human brain comprising the steps of: affixing at least one set of electrodes directly to a region of the cerebellum; generating electrical pulses having a duration of from 0.5 to 2.5 milliseconds, an amplitude of from 0.5 to 14.0 volts and a frequency of from 1 to 300 pulses per second; and applying the generated electrical pulses to said electrode.

2. A method as in claim 1 wherein a first set of electrodes are affixed to the paleocerebellum region of the cerebellum and a second set of electrodes are affixed to the neocerebellum region of the cerebellum.

3. A method as in claim 2 wherein said electrical pulses are alternately applied in bursts to said first and second sets of electrodes.

4. A method as in claim 3 wherein each burst of pulses has a duration of from 1.0 minute to 30.0 minutes.

5. A method as in claim 1, wherein the duration of the pulses is 1.0 millisecond and the pulses have a rectangular waveform.

6. A method as in claim 5, wherein the amplitude of the pules is 10.0 volts and the frequency of the pulses is 200 pulses per second.

7. A method as in claim 5, wherein the amplitude of the pulses is from 5.0 to 10.0 volts and the frequency of the pulses is 10.0 pulses per second.

Patent Citations
Cited PatentFiling datePublication dateApplicantTitle
US2721316 *Jun 9, 1953Oct 18, 1955Shaw Joseph DMethod and means for aiding the blind
US3320947 *Oct 22, 1964May 23, 1967Knoll Max HansDevice for the excitation of nerve networks
US3449768 *Dec 27, 1966Jun 17, 1969Doyle James HArtificial sense organ
US3699970 *Jun 23, 1970Oct 24, 1972Nat Res DevStriate cortex stimulator
US3735756 *Jun 23, 1971May 29, 1973Medco Products Co IncDuplex ultrasound generator and combined electrical muscle stimulator
Referenced by
Citing PatentFiling datePublication dateApplicantTitle
US4071033 *Dec 20, 1976Jan 31, 1978Nawracaj Edward PElectrotherapeutic device with modulated dual signals
US4280504 *Jan 16, 1979Jul 28, 1981Firma Somartec S.A.Device for treatment with interference currents
US4401121 *Feb 5, 1981Aug 30, 1983Firma Somartec S.A.Device for treatment with interference currents
US4524773 *Aug 24, 1983Jun 25, 1985The John Hopkins UniversityApparatus for inhibiting self-injurious behavior (SIB) in patients
US4702254 *Dec 30, 1985Oct 27, 1987Jacob ZabaraMethod of controlling/preventing involuntary movements
US4771779 *Aug 19, 1987Sep 20, 1988The Regents Of The University Of CaliforniaSystem for controlling bladder evacuation
US4867164 *Oct 26, 1987Sep 19, 1989Jacob ZabaraNeurocybernetic prosthesis
US5025807 *Jan 25, 1989Jun 25, 1991Jacob ZabaraNeurocybernetic prosthesis
US5299569 *May 3, 1991Apr 5, 1994Cyberonics, Inc.Treatment of neuropsychiatric disorders by nerve stimulation
US5559498 *Dec 30, 1994Sep 24, 1996Innotek Inc.Combination confinement and remote training system
US5571150 *Dec 19, 1994Nov 5, 1996Cyberonics, Inc.Treatment of patients in coma by nerve stimulation
US5683422 *Apr 25, 1996Nov 4, 1997Medtronic, Inc.Method and apparatus for treating neurodegenerative disorders by electrical brain stimulation
US5690681 *Mar 29, 1996Nov 25, 1997Purdue Research FoundationMethod and apparatus using vagal stimulation for control of ventricular rate during atrial fibrillation
US5700282 *Oct 13, 1995Dec 23, 1997Zabara; JacobHeart rhythm stabilization using a neurocybernetic prosthesis
US5713922 *Apr 25, 1996Feb 3, 1998Medtronic, Inc.Techniques for adjusting the locus of excitation of neural tissue in the spinal cord or brain
US5713923 *May 13, 1996Feb 3, 1998Medtronic, Inc.Techniques for treating epilepsy by brain stimulation and drug infusion
US5738625 *Jul 28, 1995Apr 14, 1998Gluck; Daniel S.Method of and apparatus for magnetically stimulating neural cells
US5752979 *Nov 1, 1996May 19, 1998Medtronic, Inc.Method of controlling epilepsy by brain stimulation
US5792186 *Apr 30, 1997Aug 11, 1998Medtronic, Inc.Method and apparatus for treating neurodegenerative disorders by electrical brain stimulation
US5800474 *Nov 1, 1996Sep 1, 1998Medtronic, Inc.Method of controlling epilepsy by brain stimulation
US5833709 *Apr 30, 1997Nov 10, 1998Medtronic, Inc.System for treating movement disorders resulting in abnormal motor behavior
US5916239 *Nov 24, 1997Jun 29, 1999Purdue Research FoundationMethod and apparatus using vagal stimulation for control of ventricular rate during atrial fibrillation
US5938689 *May 1, 1998Aug 17, 1999Neuropace, Inc.Electrode configuration for a brain neuropacemaker
US6006124 *May 1, 1998Dec 21, 1999Neuropace, Inc.Means and method for the placement of brain electrodes
US6016449 *Oct 27, 1997Jan 18, 2000Neuropace, Inc.System for treatment of neurological disorders
US6066163 *Feb 2, 1996May 23, 2000John; Michael SashaAdaptive brain stimulation method and system
US6366814 *Dec 29, 2000Apr 2, 2002Birinder R. BovejaExternal stimulator for adjunct (add-on) treatment for neurological, neuropsychiatric, and urological disorders
US6374140Apr 30, 1998Apr 16, 2002Medtronic, Inc.Method and apparatus for treating seizure disorders by stimulating the olfactory senses
US6591138Aug 31, 2000Jul 8, 2003Neuropace, Inc.Low frequency neurostimulator for the treatment of neurological disorders
US6988006Sep 20, 2002Jan 17, 2006Medtronic, Inc.Technique for adjusting the locus of excitation of electrically excitable tissue
US7004948Jan 18, 2002Feb 28, 2006Advanced Bionics CorporationCranial sealing plug
US7013177Jul 3, 2002Mar 14, 2006Advanced Bionics CorporationTreatment of pain by brain stimulation
US7209787Nov 20, 2003Apr 24, 2007Bioneuronics CorporationApparatus and method for closed-loop intracranial stimulation for optimal control of neurological disease
US7221981Mar 28, 2002May 22, 2007Northstar Neuroscience, Inc.Electrode geometries for efficient neural stimulation
US7231254Jul 12, 2004Jun 12, 2007Bioneuronics CorporationClosed-loop feedback-driven neuromodulation
US7236831Apr 8, 2003Jun 26, 2007Northstar Neuroscience, Inc.Methods and apparatus for effectuating a lasting change in a neural-function of a patient
US7242984Jan 6, 2004Jul 10, 2007Neurovista CorporationApparatus and method for closed-loop intracranial stimulation for optimal control of neurological disease
US7277758Apr 5, 2004Oct 2, 2007Neurovista CorporationMethods and systems for predicting future symptomatology in a patient suffering from a neurological or psychiatric disorder
US7299096Dec 9, 2003Nov 20, 2007Northstar Neuroscience, Inc.System and method for treating Parkinson's Disease and other movement disorders
US7302298Apr 18, 2003Nov 27, 2007Northstar Neuroscience, IncMethods and systems employing intracranial electrodes for neurostimulation and/or electroencephalography
US7305268Oct 15, 2001Dec 4, 2007Northstar Neurscience, Inc.Systems and methods for automatically optimizing stimulus parameters and electrode configurations for neuro-stimulators
US7324851Jun 1, 2004Jan 29, 2008Neurovista CorporationClosed-loop feedback-driven neuromodulation
US7353064Feb 19, 2004Apr 1, 2008Northstar Neuroscience, Inc.Systems and methods for enhancing or optimizing neural stimulation therapy for treating symptoms of movement disorders and/or other neurologic dysfunction
US7403820May 25, 2005Jul 22, 2008Neurovista CorporationClosed-loop feedback-driven neuromodulation
US7437196Jul 18, 2006Oct 14, 2008Northstar Neuroscience, Inc.Systems and methods for selecting stimulation sites and applying treatment, including treatment of symptoms of Parkinson's disease, other movement disorders, and/or drug side effects
US7483747Jul 15, 2005Jan 27, 2009Northstar Neuroscience, Inc.Systems and methods for enhancing or affecting neural stimulation efficiency and/or efficacy
US7565199Dec 9, 2003Jul 21, 2009Advanced Neuromodulation Systems, Inc.Methods for treating and/or collecting information regarding neurological disorders, including language disorders
US7565200Nov 12, 2004Jul 21, 2009Advanced Neuromodulation Systems, Inc.Systems and methods for selecting stimulation sites and applying treatment, including treatment of symptoms of Parkinson's disease, other movement disorders, and/or drug side effects
US7577481Feb 15, 2006Aug 18, 2009Advanced Neuromodulation Systems, Inc.Methods and apparatus for effectuating a lasting change in a neural-function of a patient
US7620456Mar 23, 2006Nov 17, 2009Advanced Neuromodulation Systems, Inc.Systems and methods for reducing the likelihood of inducing collateral neural activity during neural stimulation threshold test procedures
US7623928May 2, 2007Nov 24, 2009Neurovista CorporationControlling a subject's susceptibility to a seizure
US7657318Nov 14, 2005Feb 2, 2010Medtronic, Inc.Technique for adjusting the locus of excitation of electrically excitable tissue
US7672730Jun 24, 2003Mar 2, 2010Advanced Neuromodulation Systems, Inc.Methods and apparatus for effectuating a lasting change in a neural-function of a patient
US7676263Jun 21, 2007Mar 9, 2010Neurovista CorporationMinimally invasive system for selecting patient-specific therapy parameters
US7689289Mar 22, 2006Mar 30, 2010Medtronic, Inc.Technique for adjusting the locus of excitation of electrically excitable tissue with paired pulses
US7729773Oct 18, 2006Jun 1, 2010Advanced Neuromodualation Systems, Inc.Neural stimulation and optical monitoring systems and methods
US7742820Jul 18, 2006Jun 22, 2010Advanced Neuromodulation Systems, Inc.Systems and methods for selecting stimulation sites and applying treatment, including treatment of symptoms of parkinson's disease, other movement disorders, and/or drug side effects
US7747325Sep 28, 2005Jun 29, 2010Neurovista CorporationSystems and methods for monitoring a patient's neurological disease state
US7756584Sep 27, 2002Jul 13, 2010Advanced Neuromodulation Systems, Inc.Methods and apparatus for effectuating a lasting change in a neural-function of a patient
US7831305Oct 15, 2002Nov 9, 2010Advanced Neuromodulation Systems, Inc.Neural stimulation system and method responsive to collateral neural activity
US7853329Dec 29, 2006Dec 14, 2010Neurovista CorporationMonitoring efficacy of neural modulation therapy
US7894903 *Mar 24, 2006Feb 22, 2011Michael Sasha JohnSystems and methods for treating disorders of the central nervous system by modulation of brain networks
US7908009Jul 18, 2006Mar 15, 2011Advanced Neuromodulation Systems, Inc.Systems and methods for selecting stimulation sites and applying treatment, including treatment of symptoms of Parkinson's disease, other movement disorders, and/or drug side effects
US7917225Jul 18, 2006Mar 29, 2011Advanced Neuromodulation Systems, Inc.Systems and methods for selecting stimulation sites and applying treatment, including treatment of symptoms of parkinson's disease, other movement disorders, and/or drug side effects
US7930035May 2, 2007Apr 19, 2011Neurovista CorporationProviding output indicative of subject's disease state
US7974696Jul 23, 2005Jul 5, 2011Dilorenzo Biomedical, LlcClosed-loop autonomic neuromodulation for optimal control of neurological and metabolic disease
US7983762Dec 3, 2008Jul 19, 2011Advanced Neuromodulation Systems, Inc.Systems and methods for enhancing or affecting neural stimulation efficiency and/or efficacy
US8027730 *Oct 9, 2006Sep 27, 2011Michael Sasha JohnSystems and methods for treating disorders of the central nervous system by modulation of brain networks
US8036736Mar 21, 2008Oct 11, 2011Neuro Vista CorporationImplantable systems and methods for identifying a contra-ictal condition in a subject
US8065012Aug 6, 2007Nov 22, 2011Advanced Neuromodulation Systems, Inc.Methods and apparatus for effectuating a lasting change in a neural-function of a patient
US8073546Jul 12, 2010Dec 6, 2011Advanced Neuromodulation Systems, Inc.Methods and apparatus for effectuating a lasting change in a neural-function of a patient
US8126568Apr 6, 2007Feb 28, 2012Advanced Neuromodulation Systems, Inc.Electrode geometries for efficient neural stimulation
US8195300May 5, 2011Jun 5, 2012Advanced Neuromodulation Systems, Inc.Systems and methods for automatically optimizing stimulus parameters and electrode configurations for neuro-stimulators
US8295934Nov 14, 2006Oct 23, 2012Neurovista CorporationSystems and methods of reducing artifact in neurological stimulation systems
US8412335Jun 4, 2012Apr 2, 2013Advanced Neuromodulation Systems, Inc.Systems and methods for automatically optimizing stimulus parameters and electrode configurations for neuro-stimulators
US8433414Feb 17, 2012Apr 30, 2013Advanced Neuromodulation Systems, Inc.Systems and methods for reducing the likelihood of inducing collateral neural activity during neural stimulation threshold test procedures
US8467879Oct 14, 2005Jun 18, 2013Boston Scientific Neuromodulation CorporationTreatment of pain by brain stimulation
US8543199Sep 2, 2011Sep 24, 2013Cyberonics, Inc.Implantable systems and methods for identifying a contra-ictal condition in a subject
US8588933Jan 11, 2010Nov 19, 2013Cyberonics, Inc.Medical lead termination sleeve for implantable medical devices
US8606361Jul 8, 2011Dec 10, 2013Advanced Neuromodulation Systems, Inc.Systems and methods for enhancing or affecting neural stimulation efficiency and/or efficacy
US8718777Jul 24, 2009May 6, 2014Advanced Neuromodulation Systems, Inc.Methods and systems for intracranial neurostimulation and/or sensing
US8725243Dec 28, 2005May 13, 2014Cyberonics, Inc.Methods and systems for recommending an appropriate pharmacological treatment to a patient for managing epilepsy and other neurological disorders
US8762065Jun 22, 2005Jun 24, 2014Cyberonics, Inc.Closed-loop feedback-driven neuromodulation
US8781597May 5, 2010Jul 15, 2014Cyberonics, Inc.Systems for monitoring a patient's neurological disease state
US8786624Jun 2, 2010Jul 22, 2014Cyberonics, Inc.Processing for multi-channel signals
EP0033643A1 *Jan 30, 1981Aug 12, 1981Medtronic, Inc.Electro-ocular stimulation apparatus
EP1405652A2 *Mar 28, 1997Apr 7, 2004Medtronic, Inc.Apparatus for treating neurodegenerative disorders
WO1985001213A1 *Sep 11, 1984Mar 28, 1985Jacob ZabaraNeurocybernetic prosthesis
WO1992000119A1 *Jun 27, 1991Dec 29, 1991Verhoeven Jean MarieMethod and device for treating epilepsy
WO1997039795A1 *Mar 28, 1997Oct 30, 1997Medtronic IncApparatus for treating neurodegenerative disorders
WO1997039796A1 *Apr 2, 1997Oct 30, 1997Medtronic IncApparatus for treating movement disorders by closed loop brain stimulation
WO2004034997A2 *Oct 15, 2003Apr 29, 2004Medtronic IncMedical device system with relaying module for treatment of nervous system disorders
WO2008073420A2 *Dec 11, 2007Jun 19, 2008Northstar Neuroscience IncSystems and methods for treating patient hypertonicity
WO2012065215A1 *Nov 14, 2011May 24, 2012The Bionics Institute Of AustraliaElectrical stimulation for the suppression of epileptic seizures
Classifications
U.S. Classification607/45, 607/72, 607/61, 607/66
International ClassificationA61N1/372
Cooperative ClassificationA61N1/372
European ClassificationA61N1/372