|Publication number||US3970747 A|
|Application number||US 05/615,336|
|Publication date||Jul 20, 1976|
|Filing date||Sep 22, 1975|
|Priority date||Mar 11, 1974|
|Publication number||05615336, 615336, US 3970747 A, US 3970747A, US-A-3970747, US3970747 A, US3970747A|
|Inventors||Jordan B. Barth|
|Original Assignee||Colgate-Palmolive Company|
|Export Citation||BiBTeX, EndNote, RefMan|
|Patent Citations (7), Non-Patent Citations (8), Referenced by (26), Classifications (11)|
|External Links: USPTO, USPTO Assignment, Espacenet|
This is a divisional of application Ser. No. 449,620, filed Mar. 11, 1974, allowed as U.S. Pat. No. 3,932,604 which in turn is a continuation-in-part of my copending application Ser. No. 317,696, filed on Dec. 22, 1972, now abandoned.
This invention relates to an improved dentifrice. In particular it relates to a dentifrice containing a non-cariogenic sweetener which also acts as a humectant and in some instances as the sole humectant and sweetening component.
The various sweeteners that have been used in dentifrice must be used with a humectant to give a satisfactory product. Xylitol, a pentitol, has the sweetening strength of sucrose, is non-cariogenic, and has humectant properties sufficient to prevent orifice plugging of an uncapped tube of toothpaste.
The importance of the non-cariogenic property in a dentifrice sweetener is obvious. The combination of sweetening and humectant properties in a single compound improves the product and simplifies formulation by making it possible to reduce or even eliminate the content of the standard dentifrice humectants.
It is an object of this invention to provide a non-cariogenic dentifrice sweetener which also acts as a humectant.
It is another object of this invention to provide a non-cariogenic dentifrice sweetener which may be used in place of part or all of the standard dentifrice humectants and in certain instances, as a full replacement for all the sweetening agents.
It is still another object of this invention to provide a non-cariogenic dentifrice for use in oral hygiene. Other objects will be apparent from a consideration of the specification which follows.
The essential ingredients of my improved dentifrice are an abrasive, water, detergent, and xylitol. If desired, the dentifrice may also contain additional ingredients, such as gums, fluorine containing compounds, flavors, etc.
Suitable abrasives include, for example, dicalcium phosphate, tricalcium phosphate, insoluble sodium metaphosphate, aluminum hydroxide, magnesium carbonate, calcium carbonate, calcium pyrophosphate, calcium sulfate, silica, sodium aluminum silicate, polymethacrylate, bentonite, etc., or mixtures of these materials.
The detergent may be an organic anionic, nonionic, ampholytic or cationic surface-active agent, preferably one which imparts detersive and foaming properties.
Suitable detergents are water-soluble salts of higher fatty acid monosulfates, such as the sodium salts of the monosulfated monoglyceride of hydrogenated coconut oil fatty acids, higher alkyl sulfates, such as sodium dodecyl benzene sulfonate, higher alkyl sulfoacetates, higher fatty acid esters of 1, 2dihydroxy propane sulfonates, and the substantially saturated higher aliphatic acyl amides of lower aliphatic amine carboxylic acid compounds, such as those having 12 to 16 carbon atoms in the fatty acid, alkyl or acyl radicals, and the like. Examples of the last-mentioned amides are N-lauroyl sarcosine, and the sodium, potassium and ethanolamine salts of N-lauroyl, N-myristoyl or N-palmitoyl sarcosinates, all substantially free of soap or similar higher fatty acid material.
Other suitable detergents include nonionic agents, such as condensates of sorbitan monostearate with approximately 60 moles of ethylene oxide, condensates of propylene glycol ("Pluronics") and cationic surface-active germicides and antibacterial compounds such as di-isobutylphenoxyethoxyethyl ammonium chloride, tertiary amines having one fatty alkyl group of from 12 to 18 carbon atoms and two (poly) oxyethylene groups attached to the nitrogen (typically containing a total of from about two to fifty ethenoxy groups per molecule) and salts thereof with acids, and compounds of the structure: ##EQU1## where R is a fatty alkyl group containing from about 12 to 18 carbon atoms, and x, y and z total 3 or higher, as well as salts thereof with mineral or organic acids.
Suitable gums or gelling agents include the natural and synthetic gums and gumlike materials, such as Irish moss, gum tragacanth, sodium carboxymethyl cellulose (CMC), polyvinylpyrrolidone, starch, and inorganic thickeners such as "Cabosil" fumed silicon dioxide. "Laponite" (hydrous magnesium silicate clay). Syloid 244 (aerogel silica), and other organic and inorganic materials.
The fluorine-containing compound may be sodium fluoride, stannous fluoride, potassium fluoride, potassium stannous fluoride (SnF2,KF), sodium hexafluorostannate, stannous chlorofluoride, sodium fluorozirconate, and sodium monofluorophosphate.
The flavoring material may be a flavoring oil, such as oils of spearmint, peppermint, wintergreen, clove, sage, eucalyptus, marjoram, cinnamon and lemon. Where a non-bitter flavor such as orange, sodium methyl salicylate or anise licorise is employed, xylitol may serve as the sole sweetener in addition to being the humectant. Still other materials may be incorporated in the dentifrice for various purposes. Examples of these materials are coloring of whitening agents, preservatives, silicones, chlorophyll compounds, ammoniated materials such as urea, diammoniumphosphate, and mixtures thereof, antibacterial agents, etc.
A dentifrice containing my novel humectant-sweetener may have a composition within the limits set forth below.
______________________________________Abrasive 10-75%Water 10-40%Humectant, e.g., glycerine,sorbitol 0-50%Detergent 0.5- 5%Flavor 0.1- 5%Fluoride ion 0.05- 2%Sweetening agents 0- 2%Binding agents (gums and inorganicgelling agents) up to 10%Xylitol 5-60%______________________________________
The preferred xylitol content of the dentifrice is from about 10% to about 25%. To avoid a bitter taste (or aftertaste) the amount of water present should be no more than that required to give at least a 10 or 15% solution of xylitol. The amount of standard humectant used will depend on the xylitol content. If a dentifrice contains at least about 15-20% xylitol it is not necessary to use an additional humectant because orifice plugging will not occur when the toothpaste tube is left uncapped overnight. Preferably about 0.2% of a standard sweetening agent will be used. The exact amount of this ingredient will depend mainly on the taste desired. THe amounts of the other ingredients may be varied as desired.
The following specific examples are further illustrative of the nature of the present invention but it is to be understood that the invention is not limited thereto. The amounts and proportions in the examples are by weight unless otherwise indicated.
Xylitol 5.00%Carboxymethyl cellulose 1.10Glycerine 9.99Sorbitol 11.90Sodium benzoate 0.50Water 24.00Na2 PO3 F 0.76TiO2 0.40Insoluble sodium metaphosphate 36.85Hydrated alumina 5.00Anhydrous dicalcium phosphate 1.00Sodium lauryl sarcosinate 2.00Flavor 1.50TOTAL 100.00%
When the teeth are brushed with this dental cream a pleasant taste develops and remains in the oral cavity during brushing and for a short time thereafter.
Xylitol 10.00%Carboxymethyl cellulose 0.90Glycerine 9.99Sorbitol 7.00Sodium benzoate 0.50Water 19.60Na2 PO3 F 0.76TiO2 0.40Insoluble sodium metaphosphate 41.85Hydrated alumina 1.00Anhydrous dicalcium phosphate 5.00Sodium lauryl sarcosinate 2.00Flavor 1.00TOTAL 100.00%
When the teeth are brushed with this composition, the results are generally the same as those obtained with the composition of Example I.
Xylitol 10.00%Carboxymethyl cellulose 1.10Glycerine 22.00Sodium benzoate 0.50Water 24.59Na2 PO3 F 0.76CaCO3 37.25Hydrated alumina 1.00Sodium lauryl sulfate 1.50Flavor 1.30TOTAL 100.00%
Despite certain differences in the ingredients when the teeth are brushed with this composition the results are generally the same as those obtained with the compositions of Examples I and II.
Xylitol 25.00%Carboxymethyl cellulose 0.90Glycerine 1.71Sodium benzoate 0.50Water 19.88Na2 PO3 F 0.76TiO2 0.40Insoluble sodium metaphosphate 41.85Hydrated alumina 1.00Anhydrous dicalcium phosphate 5.00Sodium lauryl sarcosinate 2.00Flavor 1.00TOTAL 100.00%
When the teeth are brushed with this composition, the results are generally the same as those obtained when the compositions of the previous examples are used. In addition, no orifice plugging occurs when the tube is left uncapped overnight.
Xylitol 50.00%Carboxymethyl cellulose 1.00Sodium benzoate 0.50Water 20.50Sodium aluminum silicate 25.00Sodium lauryl sulfate 2.00Flavor 1.00TOTAL 100.00%
Again, despite the differences in the ingredients the results obtained when this composition is used are generally the same as those obtained with the compositions of the previous examples.
It will be apparent to those skilled in the art that various modifications may be made to the specific compositions described and equivalents substituted therefor.
|Cited Patent||Filing date||Publication date||Applicant||Title|
|US85166 *||Dec 22, 1868||Improved dentifrice-paste|
|US152098 *||May 4, 1874||Jun 16, 1874||Improvement in tooth-pastes|
|US396192 *||Nov 7, 1887||Jan 15, 1889||Half to henry g|
|US1484415 *||Feb 20, 1920||Feb 19, 1924||Shepherd Chemical Company||Tooth paste|
|US3296079 *||Dec 9, 1963||Jan 3, 1967||Pfizer & Co C||Products sweetened without sugar and characterized by freedom from aftertaste|
|US3655866 *||Jan 26, 1970||Apr 11, 1972||Warner Lambert Co||Sugarless gum containing dicalcium phosphate dihydrate|
|US3914434 *||Dec 7, 1973||Oct 21, 1975||Hoffmann La Roche||Non-cariogenic foods and delicacies containing xylitol as a sugar substitute|
|1||*||Grunberg et al., Int. J. Vitam. Nutr. Res. 43(2):227-232, (1973), "Xylitol and Dental Caries Efficacy of Xylitol in Reducing Dental Caries in Rats."|
|2||*||Gutschmidt et al., Deut. Lioben Runds, 57:321-324, (1961), "Determination of the sweeting Strength of Xylitol."|
|3||*||Lang Int. J. Vitamin, Forsch, 34:117-122, (1964), "Nutritional and Physiological Properties of Xylitol."|
|4||*||Makinen et al., J. Dent. Res. 51(2), Pt. 1:403-408, (1972), "Enzyme Dynamics of a Cariogenic Streptoccus, Effect of Xylitol and Sorbitol." pp. 259-275, (1972).|
|5||*||Muehlemann et al., HGLV. Odontol Acta, 14(1), 48-50, (1970), "Effect on Rat Tissue Caries of Xylitol and Sorbitol."|
|6||*||Scheinen et al., Acta. Odont. Scand., 32:383-444, (1974), "Turku Sugar Studies."|
|7||*||Scheinen et al., Acta. Odontol. Scand., 30(2):235-257(1972), "Effects of Sugars and Sugar Mixtures on Dental Plaque", pp. 259-275, (1972).|
|8||*||Scrip 146:17 Mar. 8, 1975, "Birch Sugar Said to be Effective Against Caries."|
|Citing Patent||Filing date||Publication date||Applicant||Title|
|US4203966 *||Dec 28, 1978||May 20, 1980||William F. McCord||Dentifrice with topical and systemic phosphate fluoride system|
|US4291017 *||Nov 19, 1979||Sep 22, 1981||Dental Concepts, Inc.||Method for limiting adherence of plaque and dental composition therefor|
|US4307076 *||Dec 19, 1980||Dec 22, 1981||Colgate-Palmolive Company||Toothpaste compositions|
|US4828822 *||Oct 16, 1987||May 9, 1989||Gaba International Ag||Process for stabilizing aqueous compositions containing tin salts|
|US4931294 *||Mar 21, 1988||Jun 5, 1990||Wm. Wrigley Jr. Company||Environmentally stable chewing gum composition containing xylitol|
|US4976972 *||Sep 28, 1989||Dec 11, 1990||Wm. Wrigley Jr. Company||Chewing gum with improved sweetness employing xylitol rolling compound|
|US5089255 *||Jan 25, 1991||Feb 18, 1992||Colgate-Palmolive Company||Dental remineralization|
|US5424059 *||Dec 1, 1993||Jun 13, 1995||Colgate Palmolive Company||Antibacterial antiplaque dentifrice|
|US5531982 *||Jul 14, 1994||Jul 2, 1996||Colgate Palmolive Company||Antimicrobial oral composition|
|US5900230 *||Aug 18, 1997||May 4, 1999||Squigle, Inc.||Dental products to treat and prevent periodontal disease|
|US6113885 *||Dec 18, 1998||Sep 5, 2000||Colgate Palmolive Company||Polyolefin packaged dentifrice having reduced flavor loss|
|US6238648 *||Mar 25, 1999||May 29, 2001||The Procter & Gamble Company||Anti-caries oral care compositions and their methods of use|
|US8524198||Jun 21, 2004||Sep 3, 2013||Donald W. Bailey||Xylitol dental maintenance system|
|US8834852 *||May 3, 2010||Sep 16, 2014||Kao Corporation||Composition for oral cavity|
|US9301906||Apr 6, 2011||Apr 5, 2016||Kao Corporation||Dentrifice composition|
|US20050025720 *||Jun 21, 2004||Feb 3, 2005||Donald W. Bailey||Xylitol dental maintenance system|
|US20100158820 *||Dec 28, 2009||Jun 24, 2010||Bailey Donald W||Xylitol dental maintenance system|
|US20100215592 *||Aug 26, 2010||Kao Corporation||Composition for oral cavity|
|EP0009325A1 *||Aug 21, 1979||Apr 2, 1980||Pfizer Inc.||Erythritol cointaining anti-caries compositions|
|EP0138705A2 *||Oct 9, 1984||Apr 24, 1985||Laboratoires Pharmaceutiques Goupil||Composition for hygiene and health of the parodontium of gums and teeth|
|EP0251146A2 *||Jun 23, 1987||Jan 7, 1988||Blendax GmbH||Composition for oral hygiene|
|EP0405682A1 *||Jun 25, 1990||Jan 2, 1991||Colgate-Palmolive Company||Dental remineralization|
|EP2695602A1 *||Apr 6, 2011||Feb 12, 2014||Kao Corporation||Dentifrice composition|
|EP2695602A4 *||Apr 6, 2011||Oct 1, 2014||Kao Corp||Dentifrice composition|
|WO1985001654A1 *||Oct 9, 1984||Apr 25, 1985||Goupil Jean Jacques||Composition intended to the hygienic care and health of teeth and of the periodontal tissue of gums|
|WO2000056276A1 *||Mar 23, 2000||Sep 28, 2000||The Procter & Gamble Company||Anti-caries oral care compositions|
|U.S. Classification||424/52, 514/777, 424/49|
|International Classification||A23L27/30, A61K8/34, A61Q11/00|
|Cooperative Classification||A61K8/345, A61Q11/00, A61K2800/59|
|European Classification||A61Q11/00, A61K8/34D|