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Publication numberUS3970747 A
Publication typeGrant
Application numberUS 05/615,336
Publication dateJul 20, 1976
Filing dateSep 22, 1975
Priority dateMar 11, 1974
Publication number05615336, 615336, US 3970747 A, US 3970747A, US-A-3970747, US3970747 A, US3970747A
InventorsJordan B. Barth
Original AssigneeColgate-Palmolive Company
Export CitationBiBTeX, EndNote, RefMan
External Links: USPTO, USPTO Assignment, Espacenet
Humectant sweetener
US 3970747 A
Abstract
A dentifrice which contains a non-cariogenic humectant sweetener. The dentifrice contains non-cariogenic xylitol which has the sweetening strength of sucrose and which also serves as a humectant.
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Claims(14)
What is claimed is:
1. A dentifrice aqueous dental cream toothpaste containing at least about 10% water, requiring and containing a humectant, part of said total humectant comprising a mixture comprising at least about 10% by weight of a solution in water of xylitol in combination with a further polyol humectant, thereby providing said total humectant, said xylitol adapted to function as co-humectant in said dentifrice.
2. The composition claimed in claim 1 wherein the xylitol content is from about 15 to about 60% by weight.
3. The composition claimed in claim 1 wherein the xylitol content is from about 15 to about 25% by weight.
4. The composition claimed in claim 1 wherein there is present abrasive material and detergent.
5. The composition claimed in claim 2 wherein there is present abrasive material and detergent.
6. The composition claimed in claim 3 wherein there is present a flavor material and a sweetening agent in addition to said xylitol.
7. The composition claimed in claim 1 wherein said xylitol is the sole sweetening agent.
8. The composition claimed in claim 7 additionally containing a non-bitter flavor.
9. The composition claimed in claim 1 wherein the amount of water present is no more than the amount required to give at least a 15% solution of xylitol.
10. A process for improving oral hygiene which comprises applying to the oral cavity a dentifrice as defined in claim 1.
11. A dentifrice as defined in claim 4 wherein said abrasive and detergent are included in amounts of about 10 - 75% by weight and about 0.5 to 5% by weight, respectively.
12. A dentifrice as defined in claim 5 wherein said abrasive and detergent are included in amounts of about 10 - 75% by weight and about 0.5 to 5% by weight, respectively.
13. A dentifrice as defined in claim 1 additionally containing a suitable amount of a fluorine containing compound.
14. A dentifrice as defined in claim 1 additionally containing a sufficient quantity of binding or gelling agent.
Description

This is a divisional of application Ser. No. 449,620, filed Mar. 11, 1974, allowed as U.S. Pat. No. 3,932,604 which in turn is a continuation-in-part of my copending application Ser. No. 317,696, filed on Dec. 22, 1972, now abandoned.

BACKGROUND OF THE INVENTION

This invention relates to an improved dentifrice. In particular it relates to a dentifrice containing a non-cariogenic sweetener which also acts as a humectant and in some instances as the sole humectant and sweetening component.

The various sweeteners that have been used in dentifrice must be used with a humectant to give a satisfactory product. Xylitol, a pentitol, has the sweetening strength of sucrose, is non-cariogenic, and has humectant properties sufficient to prevent orifice plugging of an uncapped tube of toothpaste.

The importance of the non-cariogenic property in a dentifrice sweetener is obvious. The combination of sweetening and humectant properties in a single compound improves the product and simplifies formulation by making it possible to reduce or even eliminate the content of the standard dentifrice humectants.

SUMMARY OF THE INVENTION

It is an object of this invention to provide a non-cariogenic dentifrice sweetener which also acts as a humectant.

It is another object of this invention to provide a non-cariogenic dentifrice sweetener which may be used in place of part or all of the standard dentifrice humectants and in certain instances, as a full replacement for all the sweetening agents.

It is still another object of this invention to provide a non-cariogenic dentifrice for use in oral hygiene. Other objects will be apparent from a consideration of the specification which follows.

The essential ingredients of my improved dentifrice are an abrasive, water, detergent, and xylitol. If desired, the dentifrice may also contain additional ingredients, such as gums, fluorine containing compounds, flavors, etc.

Suitable abrasives include, for example, dicalcium phosphate, tricalcium phosphate, insoluble sodium metaphosphate, aluminum hydroxide, magnesium carbonate, calcium carbonate, calcium pyrophosphate, calcium sulfate, silica, sodium aluminum silicate, polymethacrylate, bentonite, etc., or mixtures of these materials.

The detergent may be an organic anionic, nonionic, ampholytic or cationic surface-active agent, preferably one which imparts detersive and foaming properties.

Suitable detergents are water-soluble salts of higher fatty acid monosulfates, such as the sodium salts of the monosulfated monoglyceride of hydrogenated coconut oil fatty acids, higher alkyl sulfates, such as sodium dodecyl benzene sulfonate, higher alkyl sulfoacetates, higher fatty acid esters of 1, 2dihydroxy propane sulfonates, and the substantially saturated higher aliphatic acyl amides of lower aliphatic amine carboxylic acid compounds, such as those having 12 to 16 carbon atoms in the fatty acid, alkyl or acyl radicals, and the like. Examples of the last-mentioned amides are N-lauroyl sarcosine, and the sodium, potassium and ethanolamine salts of N-lauroyl, N-myristoyl or N-palmitoyl sarcosinates, all substantially free of soap or similar higher fatty acid material.

Other suitable detergents include nonionic agents, such as condensates of sorbitan monostearate with approximately 60 moles of ethylene oxide, condensates of propylene glycol ("Pluronics") and cationic surface-active germicides and antibacterial compounds such as di-isobutylphenoxyethoxyethyl ammonium chloride, tertiary amines having one fatty alkyl group of from 12 to 18 carbon atoms and two (poly) oxyethylene groups attached to the nitrogen (typically containing a total of from about two to fifty ethenoxy groups per molecule) and salts thereof with acids, and compounds of the structure: ##EQU1## where R is a fatty alkyl group containing from about 12 to 18 carbon atoms, and x, y and z total 3 or higher, as well as salts thereof with mineral or organic acids.

Suitable gums or gelling agents include the natural and synthetic gums and gumlike materials, such as Irish moss, gum tragacanth, sodium carboxymethyl cellulose (CMC), polyvinylpyrrolidone, starch, and inorganic thickeners such as "Cabosil" fumed silicon dioxide. "Laponite" (hydrous magnesium silicate clay). Syloid 244 (aerogel silica), and other organic and inorganic materials.

The fluorine-containing compound may be sodium fluoride, stannous fluoride, potassium fluoride, potassium stannous fluoride (SnF2,KF), sodium hexafluorostannate, stannous chlorofluoride, sodium fluorozirconate, and sodium monofluorophosphate.

The flavoring material may be a flavoring oil, such as oils of spearmint, peppermint, wintergreen, clove, sage, eucalyptus, marjoram, cinnamon and lemon. Where a non-bitter flavor such as orange, sodium methyl salicylate or anise licorise is employed, xylitol may serve as the sole sweetener in addition to being the humectant. Still other materials may be incorporated in the dentifrice for various purposes. Examples of these materials are coloring of whitening agents, preservatives, silicones, chlorophyll compounds, ammoniated materials such as urea, diammoniumphosphate, and mixtures thereof, antibacterial agents, etc.

Description of the Preferred Embodiments

A dentifrice containing my novel humectant-sweetener may have a composition within the limits set forth below.

______________________________________Abrasive               10-75%Water                  10-40%Humectant, e.g., glycerine,sorbitol               0-50%Detergent              0.5- 5%Flavor                 0.1- 5%Fluoride ion           0.05- 2%Sweetening agents      0- 2%Binding agents (gums and inorganicgelling agents)        up to 10%Xylitol                5-60%______________________________________

The preferred xylitol content of the dentifrice is from about 10% to about 25%. To avoid a bitter taste (or aftertaste) the amount of water present should be no more than that required to give at least a 10 or 15% solution of xylitol. The amount of standard humectant used will depend on the xylitol content. If a dentifrice contains at least about 15-20% xylitol it is not necessary to use an additional humectant because orifice plugging will not occur when the toothpaste tube is left uncapped overnight. Preferably about 0.2% of a standard sweetening agent will be used. The exact amount of this ingredient will depend mainly on the taste desired. THe amounts of the other ingredients may be varied as desired.

The following specific examples are further illustrative of the nature of the present invention but it is to be understood that the invention is not limited thereto. The amounts and proportions in the examples are by weight unless otherwise indicated.

EXAMPLE I

Xylitol               5.00%Carboxymethyl cellulose                 1.10Glycerine             9.99Sorbitol              11.90Sodium benzoate       0.50Water                 24.00Na2 PO3 F   0.76TiO2             0.40Insoluble sodium metaphosphate                 36.85Hydrated alumina      5.00Anhydrous dicalcium phosphate                 1.00Sodium lauryl sarcosinate                 2.00Flavor                1.50TOTAL                 100.00%

When the teeth are brushed with this dental cream a pleasant taste develops and remains in the oral cavity during brushing and for a short time thereafter.

EXAMPLE II

Xylitol               10.00%Carboxymethyl cellulose                 0.90Glycerine             9.99Sorbitol              7.00Sodium benzoate       0.50Water                 19.60Na2 PO3 F   0.76TiO2             0.40Insoluble sodium metaphosphate                 41.85Hydrated alumina      1.00Anhydrous dicalcium phosphate                 5.00Sodium lauryl sarcosinate                 2.00Flavor                1.00TOTAL                 100.00%

When the teeth are brushed with this composition, the results are generally the same as those obtained with the composition of Example I.

EXAMPLE III

Xylitol               10.00%Carboxymethyl cellulose                 1.10Glycerine             22.00Sodium benzoate       0.50Water                 24.59Na2 PO3 F   0.76CaCO3            37.25Hydrated alumina      1.00Sodium lauryl sulfate 1.50Flavor                1.30TOTAL                 100.00%

Despite certain differences in the ingredients when the teeth are brushed with this composition the results are generally the same as those obtained with the compositions of Examples I and II.

EXAMPLE IV

Xylitol               25.00%Carboxymethyl cellulose                 0.90Glycerine             1.71Sodium benzoate       0.50Water                 19.88Na2 PO3 F   0.76TiO2             0.40Insoluble sodium metaphosphate                 41.85Hydrated alumina      1.00Anhydrous dicalcium phosphate                 5.00Sodium lauryl sarcosinate                 2.00Flavor                1.00TOTAL                 100.00%

When the teeth are brushed with this composition, the results are generally the same as those obtained when the compositions of the previous examples are used. In addition, no orifice plugging occurs when the tube is left uncapped overnight.

EXAMPLE V

Xylitol               50.00%Carboxymethyl cellulose                 1.00Sodium benzoate       0.50Water                 20.50Sodium aluminum silicate                 25.00Sodium lauryl sulfate 2.00Flavor                1.00TOTAL                 100.00%

Again, despite the differences in the ingredients the results obtained when this composition is used are generally the same as those obtained with the compositions of the previous examples.

It will be apparent to those skilled in the art that various modifications may be made to the specific compositions described and equivalents substituted therefor.

Patent Citations
Cited PatentFiling datePublication dateApplicantTitle
US85166 *Dec 22, 1868 Improved dentifrice-paste
US152098 *May 4, 1874Jun 16, 1874 Improvement in tooth-pastes
US396192 *Nov 7, 1887Jan 15, 1889 Half to henry g
US1484415 *Feb 20, 1920Feb 19, 1924Shepherd Chemical CompanyTooth paste
US3296079 *Dec 9, 1963Jan 3, 1967Pfizer & Co CProducts sweetened without sugar and characterized by freedom from aftertaste
US3655866 *Jan 26, 1970Apr 11, 1972Warner Lambert CoSugarless gum containing dicalcium phosphate dihydrate
US3914434 *Dec 7, 1973Oct 21, 1975Hoffmann La RocheNon-cariogenic foods and delicacies containing xylitol as a sugar substitute
Non-Patent Citations
Reference
1 *Grunberg et al., Int. J. Vitam. Nutr. Res. 43(2):227-232, (1973), "Xylitol and Dental Caries Efficacy of Xylitol in Reducing Dental Caries in Rats."
2 *Gutschmidt et al., Deut. Lioben Runds, 57:321-324, (1961), "Determination of the sweeting Strength of Xylitol."
3 *Lang Int. J. Vitamin, Forsch, 34:117-122, (1964), "Nutritional and Physiological Properties of Xylitol."
4 *Makinen et al., J. Dent. Res. 51(2), Pt. 1:403-408, (1972), "Enzyme Dynamics of a Cariogenic Streptoccus, Effect of Xylitol and Sorbitol." pp. 259-275, (1972).
5 *Muehlemann et al., HGLV. Odontol Acta, 14(1), 48-50, (1970), "Effect on Rat Tissue Caries of Xylitol and Sorbitol."
6 *Scheinen et al., Acta. Odont. Scand., 32:383-444, (1974), "Turku Sugar Studies."
7 *Scheinen et al., Acta. Odontol. Scand., 30(2):235-257(1972), "Effects of Sugars and Sugar Mixtures on Dental Plaque", pp. 259-275, (1972).
8 *Scrip 146:17 Mar. 8, 1975, "Birch Sugar Said to be Effective Against Caries."
Referenced by
Citing PatentFiling datePublication dateApplicantTitle
US4203966 *Dec 28, 1978May 20, 1980William F. McCordDentifrice with topical and systemic phosphate fluoride system
US4291017 *Nov 19, 1979Sep 22, 1981Dental Concepts, Inc.Method for limiting adherence of plaque and dental composition therefor
US4307076 *Dec 19, 1980Dec 22, 1981Colgate-Palmolive CompanyToothpaste compositions
US4828822 *Oct 16, 1987May 9, 1989Gaba International AgProcess for stabilizing aqueous compositions containing tin salts
US4931294 *Mar 21, 1988Jun 5, 1990Wm. Wrigley Jr. CompanyEnvironmentally stable chewing gum composition containing xylitol
US4976972 *Sep 28, 1989Dec 11, 1990Wm. Wrigley Jr. CompanyChewing gum with improved sweetness employing xylitol rolling compound
US5089255 *Jan 25, 1991Feb 18, 1992Colgate-Palmolive CompanyDental remineralization
US5424059 *Dec 1, 1993Jun 13, 1995Colgate Palmolive CompanyAntibacterial antiplaque dentifrice
US5531982 *Jul 14, 1994Jul 2, 1996Colgate Palmolive CompanyAntimicrobial oral composition
US5900230 *Aug 18, 1997May 4, 1999Squigle, Inc.Dental products to treat and prevent periodontal disease
US6113885 *Dec 18, 1998Sep 5, 2000Colgate Palmolive CompanyPolyolefin packaged dentifrice having reduced flavor loss
US6238648 *Mar 25, 1999May 29, 2001The Procter & Gamble CompanyAnti-caries oral care compositions and their methods of use
US8524198Jun 21, 2004Sep 3, 2013Donald W. BaileyXylitol dental maintenance system
US8834852 *May 3, 2010Sep 16, 2014Kao CorporationComposition for oral cavity
US9301906Apr 6, 2011Apr 5, 2016Kao CorporationDentrifice composition
US20050025720 *Jun 21, 2004Feb 3, 2005Donald W. BaileyXylitol dental maintenance system
US20100158820 *Dec 28, 2009Jun 24, 2010Bailey Donald WXylitol dental maintenance system
US20100215592 *Aug 26, 2010Kao CorporationComposition for oral cavity
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EP0251146A2 *Jun 23, 1987Jan 7, 1988Blendax GmbHComposition for oral hygiene
EP0405682A1 *Jun 25, 1990Jan 2, 1991Colgate-Palmolive CompanyDental remineralization
EP2695602A1 *Apr 6, 2011Feb 12, 2014Kao CorporationDentifrice composition
EP2695602A4 *Apr 6, 2011Oct 1, 2014Kao CorpDentifrice composition
WO1985001654A1 *Oct 9, 1984Apr 25, 1985Goupil Jean JacquesComposition intended to the hygienic care and health of teeth and of the periodontal tissue of gums
WO2000056276A1 *Mar 23, 2000Sep 28, 2000The Procter & Gamble CompanyAnti-caries oral care compositions
Classifications
U.S. Classification424/52, 514/777, 424/49
International ClassificationA23L27/30, A61K8/34, A61Q11/00
Cooperative ClassificationA61K8/345, A61Q11/00, A61K2800/59
European ClassificationA61Q11/00, A61K8/34D