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Publication numberUS3976658 A
Publication typeGrant
Application numberUS 05/486,345
Publication dateAug 24, 1976
Filing dateJul 8, 1974
Priority dateJul 13, 1973
Also published asDE2433111A1
Publication number05486345, 486345, US 3976658 A, US 3976658A, US-A-3976658, US3976658 A, US3976658A
InventorsLajos Avar, Kurt Hofer, Martin Preiswerk
Original AssigneeSandoz Ltd.
Export CitationBiBTeX, EndNote, RefMan
External Links: USPTO, USPTO Assignment, Espacenet
Pyrazole derivatives
US 3976658 A
Abstract
New ultraviolet light-absorbing compounds of the formula ##SPC1##
In which
R1 is a substituent, e.g. alkyl,
R2 is a substituent, e.g. alkyl,
R3 is hydrogen or a substituents, e.g. alkyl,
n is 1, 2 or 3, and
R is an n-valent, optionally substituted benzene radical, or a 1- or 2-valent naphthalene or heterocyclic radical,
Which are producible by known processes.
Such compounds are useful as stabilizers of organic materials, particularly plastics materials, against the degrading action of ultraviolet light and can be either applied as a coating on the organic material, or incorporated therein.
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Claims(5)
What is claimed is:
1. A compound of the formula I, ##SPC12##
wherein
R1 and R2, independently, are C1-4 alkyl or unsubstituted phenyl, and
R is phenyl monosubstituted in the ortho- or para-position by a hydroxy group and mono- or disubstituted in the meta-position(s) by a tertiary butyl group, wherein the tertiary butyl group or at least one of the two tertiary butyl groups is adjacent to the hydroxy group, or phenyl monosubstituted by C1-4 alkoxy.
2. A compound according to claim 1, of the formula, ##SPC13##
3. A compound according to claim 1, of the formula, ##SPC14##
4. A compound according to claim 1, of the formula, ##SPC15##
5. A compound according to claim 1, of the formula, ##SPC16##
Description

The present invention relates to a class of novel pyrazole derivatives which are useful as stabilizers of organic materials against the adverse effects of ultraviolet light.

Accordingly, the present invention provides a class of compounds of the formula I, ##SPC2##

in which

R1 is a C1-22 alkyl radical, a C5-12 cycloalkyl radical, a C6-12 cycloalkyl-alkyl radical, a C7-12 aralkyl radical, of which the alkyl radical and the alkyl moiety of the cycloalkyl-alkyl radical are uninterrupted or interrupted by 1 or 2 sulphur atoms or by --COO--, and the aryl nucleus of the aralkyl radical is unsubstituted or substituted by a hydroxyl group and/or 1 or 2 C1-12 alkyl radicals, or a phenyl group, unsubstituted or substituted by one or more substituents selected from 1 or 2 halogen atoms, a cyano group, a hydroxyl group, 1 or 2 C1-12 alkyl radicals, 1 or 2 C1-12 alkoxy radicals, a phenyl group and the radicals R4 --O-- and R4 --SO2 --, wherein R4 is a phenyl group, unsubstituted or substituted by 1 or 2 C1-8 alkyl radicals,

R2, independently of R1, has one of the significances of R1, or is a cyano group or the radical --COOR5, wherein R5 is a C1-12 alkyl radical, a C5-12 cycloalkyl radical, a C6-12 cycloalkyl-alkyl radical or a phenyl group, unsubstituted or substituted by a hydroxyl group and/or 1 or 2 C1-8 alkyl radicals,

R3 is a hydrogen atom or one of the significances of R1, --COR1 or --COOR5, j

n is 1, 2 or 3, and

R, when n is 1, is a phenyl group, unsubstituted or substituted by a total of up to 3 substituents selected from 1 hydroxyl group, 1 to 3 halogen atoms, 1 phenyl group, 1 benzyl group, 1 phenoxy group, 1 to 3 alkyl radicals each containing 1 to 8 carbon atoms and the sum of the carbon atoms not exceeding 12, and 1 to 3 alkoxy radicals each containing 1 to 22 carbon atoms and the sum of the carbon atoms not exceeding 22, or a monovalent naphthalene radical, or a monovalent radical of thiophene, benzothiophene, dibenzothiophene, furan, benzofuran or dibenzofuran, and when n is 2, is a phenylene group, unsubstituted or substituted by a C1-4 alkyl radical and/or a halogen atom, or a divalent naphthalene radical, or a divalent radical of thiophene or dibenzofuran, and when n is 3, is a 1,3,5-trivalent benzene radical.

A preferred group of ultraviolet stabilizing compounds of the formula I are those of the formula Ia, ##SPC3##

in which

each of R1 ' and R2 ' , independently, is a C1-8 alkyl radical or a phenyl group, unsubstituted or substituted by up to 4 substituents selected from a hydroxyl group, a halogen atom and 1 or 2 C1-4 alkyl radicals,

R3 ' is a hydrogen atom or one of the significances of R1 ' or --COR1 ' ,

n' is 1 or 2, and

R', when n is 1, is a phenyl group, unsubstituted or substituted by a total of up to 3 substituents selected from 1 hydroxyl group, 1 C1-6 alkoxy radical and 1 to 3 C1-6 alkyl radicals, the sum of the carbon atoms of these substituents not exceeding 12, and when n is 2, is a phenylene group, unsubstituted or substituted by a C1-4 alkyl radical;

A preferred group of ultraviolet stabilizing compounds of the formula Ia are those of the formula Ib, ##SPC4##

in which

each of R1 " and R2 " , independently, is a C1-4 alkyl radical or a phenyl group, unsubstituted or substituted by a halogen atom,

R3 " is a hydrogen atom or one of the significances of R1 ' , as hereinbefore defined,

n' is 1 or 2, and

R", when n is 1, is a phenyl group, unsubstituted or substituted by a total of up to 3 substituents selected from 1 hydroxyl group, 1 C1-4 alkoxy radical and 1 to 3 C1-4 alkyl radicals, the sum of the carbon atoms of these substituents not exceeding 10, and when n is 2, is a phenylene group;

A preferred group of ultraviolet stabilizing compounds of the formula Ib are those of the formula Ic, ##SPC5##

in which

R1 " , r2 " and R3 " are as previously defined, and

R"' is a phenyl group which is substituted in the ortho- or para-position by a hydroxyl group and by 1 or 2 tertiary butyl groups in meta-position(s) adjacent to the hydroxyl group, or by a C1-4 alkoxy radical.

In this specification, an alkyl radical, if not otherwise stated, may be primary, secondary or tertiary, and may be derived from a natural aliphatic hydrocarbon which is branched in any way. Examples of primary alkyl radicals are methyl, ethyl, n-propyl, n-butyl, n-pentyl, n-hexyl and unbranched primary C7-22 alkyl radicals, of secondary alkyl radicals are isopropyl and 2-butyl, and of tertiary alkyl radicals are tertiary butyl and 2-methyl-2-butyl. Examples of alkyl radicals with the appropriate number of carbon atoms serve to exemplify the alkyl moieties of alkoxy radicals.

Examples of cycloalkyl radicals are cyclopentyl, cyclohexyl, cycloheptyl and cyclododecyl, and of cycloalkyl-alkyl are cyclohexyl-methyl and 2-cyclohexyl-ethyl. To exemplify aralkyl radicals envisaged in this specification may be mentioned benzyl and 2-phenylethyl.

By the term `halogen` is meant fluorine, chlorine or bromine, of which chlorine is the preferred halogen atom.

Alkyl radicals or cycloalkyl-alkyl radicals whose aliphatic chains are interrupted by 1 or 2 sulphur atoms or by --COO-- are exemplified by CH3 --S--CH2 CH2 --, C12 H25 --S--(CH2)8 --, C2 H5 OCOCH2 --, C12 H25 OCOCH2 -- and C8 H17 OCOCH2 --.

Examples of R1 when signifying a substituted phenyl group are ##SPC6##

and examples of R are ##SPC7##

In the above formulae I, Ia and Ib, n or n' is preferably 1 and the preferred meaning of R,R' and R", respectively, is a phenyl group which is substituted in the ortho- or para-position by a hydroxyl group and by 1 or or 2 tertiary butyl groups in meta-position(s) adjacent to the hydroxyl group, or by a C1-4 alkoxy radical.

The present invention also provides a process for producing a compound of the formula I, which comprises reacting a compound of the formula II, ##SPC8##

in which

R1, r2 and R3 are as defined above,

with a compound of the formula III,

r -- (cooh)n                                          III

in which

R and n are as defined above,

or a functional derivative thereof.

The reaction between the compounds of the formulae II and III is advantageously effected in a reaction-inert organic solvent, in which the reagents may be dissolved or even suspended, preferably by heating within the temperature range 20 to 110C. Suitable solvents for the reaction include benzene, xylene, cymene, diphenylether, tetrahydrofuran and dioxan.

When an acid chloride is used as the functional derivative of a compound of the formula III, this being the preferred functional derivative, hydrogen chloride is liberated in the reaction. In such a case, an acid-binding agent, e.g. lime, an alkali metal carbonate or bicarbonate, pyridine, a trialkylamine or a dialkylaniline, is preferably present in the reaction medium. Additionally it is preferable to effect the reaction in the absence of humidity.

The present invention further provides a method of stabilizing an organic material against the action of ultraviolet light comprising treating the organic material with a compound of the formula I, as hereinbefore defined. By the term "treating" as used herein, is meant either incorporating into the body of the organic material, or surface coating the organic material, in a manner known per se. Thus the method of the invention comprises treating the organic material, either by way of mixing the compound of the formula I with the organic material, or by way of coating the compound of the formula I as a protective layer on the surface of the organic material. Through its ultraviolet light-absorbing property, the compound of the formula I, incorporated in or coated on an organic material sensitive to ultraviolet light, protects the material from the degradative action of ultraviolet light.

Suitable organic materials for such protective treatment include polyolefins, especially polyethylene and polypropylene, polyesters, polymethylmethacrylates, polyphenylene oxides, polyurethanes, polystyrene, ABS-terpolymers, polyamides, especially nylon, polypropylene oxide, polyacrylonitrile and copolymers of the aforementioned polymers. Preferably the compounds of the formula I are used, according to the method of the present invention, to stabilize polypropylene, polyethylene, polyester, polyamide, polyurethane, polyacrylonitrile, ABS-terpolymers, terpolymers of acrylic ester, styrene and acrylonitrile, and copolymers of styrene and acrylonitrile and of styrene and butadiene. As well as the aforementioned synthetic materials, natural materials, e.g. rubber, cellulose, wool and silk, may be stabilized by a compound of the formula I according to the method of the present invention.

The materials to be protected according to the method of the present invention may be in the form of plates, rods, coatings, sheets, fibres, strips, films, granules, powders and other solid forms, or in solutions, emulsions or dispersions.

The incorporation into or coating of the particular organic material to be treated with a compound of the formula I may be effected by known methods. In one embodiment of the method of the invention, the organic material, for example in granular form, is intimately mixed with one or more compounds of the formula I, for example in a kneader or other suitable mixing device, and is subsequently extruded to its final form. Examples of the forms taken by the product of such a process are sheets, loops and filaments. In another embodiment, textile threads or fabrics are treated with one or more compounds of the formula I in an aqueous bath containing the stabilizer in dispersion. Textiles of polyethylene terephthalate and cellulose acetate are particularly suitable for such processing.

Synthetic materials do not necessarily have to be completely polymerized or condensed before treatment with compounds of the formula I, since monomers of prepolymers may be mixed with such stabilizers and thereafter converted to products in their final forms by condensation or polymerisation.

The compounds of the present invention are not only employable for the stabilization against ultraviolet light of clear films, but may also be used to stabilize opaque, semi-opaque or translucent organic materials whose surfaces are susceptible to degradation by ultraviolet light. Examples of such latter materials are foamed plastics, opaque films and coatings, opaque papers, transparent and opaque dyed plastics, fluorescent pigments, automobile and furniture polishes, creams and lotions.

The amount of stabilizer of the formula I suitably employed in the method of the present invention will naturally depend on the mode of application, the particular compound of formula I employed, and the nature and form of the organic material to be treated. However, in general satisfactory results are obtained when the amount of stabilizer of the formula I employed is between 0.01 and 5%, preferably between 0.05 and 1%, of the weight of the organic material to be treated.

The stabilized organic material may only contain, as ultraviolet stabilizer, one or more compounds of the formula I, or it may additionally contain other adjuvants for improving its properties. Such other adjuvants may be, for example, further stabilizers or co-stabilizers against the adverse effects of heat, oxygen or ultraviolet light, and they may belong to quite different chemical classes to that of the compounds of formula I.

A further feature of the present invention comprises the organic materials which contain one or more compounds of the formula I as stabilizers against the adverse effects of ultraviolet light. In accordance with the methods hereinbefore described for the production of such stabilized organic materials, the latter may contain from 0.01 to 5% by weight of one or more compounds of the formula I as stabilizing agent, or preferably from 0.05 to 1% by weight.

In the following Examples, which illustrate the compounds of the present invention, processes for their production and methods of their application, the parts and percentages are by weight and the temperatures are in degrees centigrade. The indicated structures are verified by microanalysis and spectroscopic analysis.

EXAMPLE 1

23.6 Parts of 1,3-diphenyl-pyrazol-5-one and 8 parts of pyridine are added to 200 parts of toluene. 26.8 Parts of 3,5-di-tert.-butyl-4-hydroxybenzoyl chloride are added in portions to the solution whilst stirring, at 20C, and the solution is left to react further at this temperature until no pyrazolone is detectable. The mixture is then washed with water, the organic phase is separated and dried, and the solvent distilled off. The residue is crystallized from ethanol. The compound having a melting point of 150 to 151C of formula ##SPC9##

is obtained.

EXAMPLE 2

11.8 Parts of 1,3-diphenyl-pyrazol-5-one and 6.0 parts of triethylamine are added to 100 parts of toluene. 9.8 Parts of 4-tert.-butyl-benzoyl chloride are added in portions to the solution whilst stirring, at 60C, and the solution is left to react further at this temperature until no pyrazolone is detectable. The mixture is then washed with water, the organic phase is separated, dried and the solvent distilled off. The residue is crystallized from hexane. The compound having a melting point of 106 to 107C of formula ##SPC10##

is obtained.

The following compounds, which are listed in Table 1, are produced in a similar manner.

                                  TABLE I__________________________________________________________________________ ##STR1##No.  R1 R2               R3   R         M.p.C__________________________________________________________________________ ##STR2##        CH3 --                ##STR3##                          ##STR4## 215-162 ##STR5##        CH3--                ##STR6##                          ##STR7## 170-723    CH3 --        CH3 --               H                          ##STR8## 139- 404 ##STR9##        CH3 --               H                          ##STR10##                                   152-545 ##STR11##        C3 H7 --               H                          ##STR12##                                   93-956 ##STR13##        CH3 --               H                          ##STR14##                                   140-1417 ##STR15##        CH3 --               H                          ##STR16##                                   81-828 ##STR17##        CH3 --               H                          ##STR18##                                   132-1339 ##STR19##        CH3 --               H                          ##STR20##                                   86-8810 ##STR21##        CH3 --               H                          ##STR22##                                   130-13111 ##STR23##        CH3 --               C2 H5 --                          ##STR24##                                   144-14512 ##STR25##        CH3 --               --C4 H9 (n)                          ##STR26##                                   134-13513 ##STR27##        --COOC2 H5               H                          ##STR28##                                   63-6414 ##STR29##         ##STR30##               H                          ##STR31##                                   135-13615 ##STR32##         ##STR33##               H                          ##STR34##                                   120-121__________________________________________________________________________ ##STR35##   In a similar manner, the following compounds were also produced

Non-stabilized polypropylene is mixed intimately with 0.5% of the compound of Examples 1, 2 and Nos. 1, 6 and 7 of Table 1 on a roller mill at 180C and is processed to form sheets of 0.3 mm thickness. These are tested in the climate test to demonstrate their resistance against the action of ultraviolet light by the De La Rue method. The test is carried out at 40C, with 75% relative humidity and strong ventilation, using 16 Philips Sunlamps and 16 Philips Blacklamps. Stabilized polypropylene shows considerably better results than non-stabilized polypropylene. Non-stabilized polyvinyl chloride and polyvinyl chloride containing 0.5% of the compound No. 1 of Table 1 are tested similarly in the climate test.

Similar results may be obtained for polyethylene, ABS-terpolymers, polyethylene terephthalate, cellulose acetobutyrate, polyamide 6, polystyrene, polycarbonate and polyurethane.

Patent Citations
Cited PatentFiling datePublication dateApplicantTitle
US2476986 *Jul 26, 1949 Elmobe louis martin
US2476987 *May 3, 1946Jul 26, 1949 S-acyloxy pyrazqles and method foe
Non-Patent Citations
Reference
1 *Dallon et al., Def. Pub. of Ser. No. 32,428 filed 4/27/1970, published June 1, 1971, Def. Pub. No. T887,007.
Referenced by
Citing PatentFiling datePublication dateApplicantTitle
US4101508 *Oct 26, 1976Jul 18, 1978Argus Chemical Corporation2,2,6,6-Tetramethyl-4-piperidyl bicyclic heptane and octane carboxylic acid esters as stabilizers for synthetic polymers
US4111901 *Jun 6, 1977Sep 5, 1978Borg-Warner CorporationHindered five-membered nitrogen rings as polyolefin stabilizers
US4146726 *Sep 30, 1977Mar 27, 1979Sankyo Company LimitedHerbicides
US4160098 *Apr 28, 1977Jul 3, 1979Bayer AktiengesellschaftPyrazole derivatives
US4207325 *Jan 17, 1978Jun 10, 1980Bayer AktiengesellschaftDiuretic, saluretic, antihypertensive and antithrombotic properties
US4687858 *Jan 15, 1985Aug 18, 1987Sankyo Company LimitedHerbicides
US7141104 *May 10, 2004Nov 28, 2006Agfa-GevaertUV-absorbing ink composition for ink-jet printing
Classifications
U.S. Classification548/370.4, 524/106, 252/405, 524/105
International ClassificationC09K3/00, C07D231/24, C07D231/26, C07D231/22, C08K5/3445, C07D231/20
Cooperative ClassificationC07D231/22, C07D231/24, C07D231/26, C07D231/20, C08K5/3445
European ClassificationC07D231/20, C07D231/22, C07D231/24, C07D231/26, C08K5/3445