|Publication number||US4302675 A|
|Application number||US 06/113,871|
|Publication date||Nov 24, 1981|
|Filing date||Jan 21, 1980|
|Priority date||Jan 21, 1980|
|Publication number||06113871, 113871, US 4302675 A, US 4302675A, US-A-4302675, US4302675 A, US4302675A|
|Inventors||Robert H. Wake, Stephen C. Gottschalk, Kendall A. Smith|
|Original Assignee||Technicare Corporation|
|Export Citation||BiBTeX, EndNote, RefMan|
|Patent Citations (4), Non-Patent Citations (3), Referenced by (50), Classifications (6), Legal Events (1)|
|External Links: USPTO, USPTO Assignment, Espacenet|
This invention relates to multiplanar tomography in nuclear medicine. An apparatus and method are disclosed for reconstructing a three-dimensional distribution of radioisotopes in a volume of interest utilizing a gamma camera and a rotating collimator in which the holes are slanted relative to the facial plane of the camera.
Conventional nuclear medicine techniques produce an image depicting the distribution of radioactive compounds within organs of the human body by filtering the high energy photons or gamma rays emitted by those compounds by means of a "collimator." Conventional collimators typically have a thickness of radiation absorbent material punctuated by a large number of parallel, relatively small diameter holes. These holes are of such small diameter compared to the thickness of the collimator that only those photons that enter the holes at the angle of the hole can pass therethrough. The holes of such conventional collimators are typically perpendicular to the plane of their faces. A photon that passes through the collimator produces a flash of light as it strikes a scintillation crystal located behind the collimator. Each such strike is amplified by a photomultiplier to generate a detectable signal. The pattern of these flashes represents the distribution of radioisotope aligned directly in front of each of the holes. The image generated from the processing of a great many of such signals is a two-dimensional projection of a three-dimensional distribution as a conventional X-ray photograph is a two-dimensional projection of a three-dimensional volume of interest. Such two-dimensional images of radioisotope distribution may be achieved by the well-known scintillation camera, also called the Anger camera after its inventor, and described in U.S. Pat. No. 3,011,057.
It is often important to the interpretation of nuclear medicine studies to understand the actual three-dimensional distribution of isotope within the organ being studied. In a conventional nuclear medicine imaging technique, however, one spatial dimension of information is lost each time as image is produced. Though images can be produced from various viewing angles and the resulting pictures considered together, it is often difficult to combine these various views into an understanding of the actual three-dimensional distribution.
Several techniques have been utilized in an attempt to produce three-dimensional "image" of isotope distribution within an organ.
Earlier techniques included moving the patient and/or detector so that radioactivity from other than a single depth is "blurred". One such method is disclosed in U.S. Pat. No. 3,612,865 to Walker. No actual removal of out-of-plane activity occurs, but rather such information is spread out in the image so that any information distant from the plane of interest becomes less pronounced. However, there appears a high background activity in the resulting image. The depth where the blurring is minimized is varied by adjusting the processing circuits. Multiple images may be produced, each emphasizing a different depth.
Other techniques rely on a focusing technique to increase collimator sensitivity at a certain depth. Several techniques for achieving depth discrimination using rectilinear scanning including inclining the detectors is disclosed in Kuhl, et al., "Image separation Radioisotope Scanning" 80 Radiology (1963) 653.
More recent work has begun to utilize various reconstruction techniques to separate data from multiple views into separate planes, each representing the isotope distribution at a specific depth from the front of the detector.
Several reconstruction methods to generate a three-dimensional density distribution are discussed in Gilbert, P., "Iterative Methods for the Three-dimensional Reconstruction of an Object from Projections," 36 J. Theor. Biol. (1972) 105. Gilbert discusses and compares several iterative reconstruction methods including the Algebraic Reconstruction Technique (ART) and the Simultaneous Iterative Reconstruction Technique (SIRT).
Various techniques have been used to produce multiple views and to optimize the information obtained from them. These include various types of coded apertures, freznel zone plates, and multiple overlapping pinholes. All of these techniques have performed well with limited source distributions, but background activity and extended sources have limited the quality of the images.
A recent development is the seven pinhole, non-overlapping images technique described by Vogel et al., 19 Journal of Nuclear Medicine (1978) 648. Seven independent projections are produced simultaneously, through seven pinholes, each viewing a common volume directly in front of the collimator. The seven images are processed by a reconstruction technique to yield multiple planar images, each representing a slice through the common volume. This technique has shown improved detection sensitivity in comparison with conventional collimators.
Applicants have discovered a method of multiplanar emission tomography with specific application in nuclear medicine and in particular for cardiac studies. Applicants have further discovered an apparatus for carrying out multiplanar imaging using a planar detector such as a scintillation camera in combination with a rotatable collimator having a tightly packed array of a multiplicity of apertures extending through the collimator at an angle relative to the plane of the detector.
In a preferred embodiment, the apparatus for producing a multiplanar representation of a radioisotope distribution within a volume of interest comprises a rotatable collimator having a multiplicity of apertures to permit the passage of photons therethrough, wherein the apertures are slanted relative to the axis of rotation of the collimator. The apparatus further comprises a planar imaging device disposed adjacent the collimator for detecting the photons passing through the apertures of the collimator from the volume of interest, means for recording a plurality of projections of the volume of interest, each projection acquired from the photons detected by the imaging device during an associated angular orientation assumed by the rotated collimator, reconstruction means for generating a three dimensional array from the plurality of projections, wherein the three dimensional array is a simulation of the radioisotope distribution within the volume of interest, and means for separating the three dimensional array into a plurality of discrete planar sections, each section representing a planar section of the volume of interest.
In a preferred embodiment the method of multiplanar emission tomography comprises directing a collimator having a multiplicity of apertures toward a photon emitting volume of interest having a radioisotope distribution, acquiring photons from the emitting volume of interest by a detector positioned adjacent the collimator such that the collimator is interposed between the detector and the volume of interest, rotating the collimator during photon acquisition to record a plurality of projections each corresponding to an angular orientation of the collimator; and reconstructing a three dimensional array of the radioisotope distribution within the volume of interest by comparison with the plurality of projections, the array being separable into multiple planes of predetermined width, each such plane representing a planar section of the volume of interest.
FIG. 1 is a schematic block diagram of the multiplanar emission tomography according to the present invention including rotatable collimator and imaging device;
FIG. 2 is a plan view of a rotatable collimator and mounting fixture therefor;
FIG. 3 is a section of FIG. 2 taken along line 3--3 showing a volume of interest viewable through the collimator;
FIG. 4 shows a detail of the collimator and fixture of FIG. 2 on an enlarged scale;
FIG. 5 is a sectional detail of the apertures of the collimator of FIG. 2;
FIG. 6 is a section of FIG. 5 taken along line 6--6 illustrating the slant of the apertures of FIG. 5.
FIG. 1 shows a section of a collimator 1 retained by a fixture or mount 2 and positioned adjacent a planar imaging device such as a scintillation camera 3, typically an Anger gamma ray camera. The collimator 1 is shown in greater detail in FIGS. 2 and 3. Collimator 1 is made of lead or other radiation opaque material. The lead collimator 1 has a multiplicity of holes or apertures 20 extending through its thickness.
Holes 20, shown in detail in FIG. 5, are normally parallel to each other although diverging or converging orientations can be used. The holes 20 are generally distributed evenly over the area of the collimator 1 although an uneven distribution or uneven hole sizes or shapes are suitable for special cases. In a preferred embodiment, the holes 20 are triangular in cross section, though they may be generally cylindrical. The holes 20 are generally aligned at an angle relative to the normal direction α as shown in FIG. 6 nonperpendicular to the face of the scintillation camera 3.
The collimator 1 is mounted in front of and parallel to the face or crystal of the scintillation camera 3 in the fixture or mount 2. The fixture 2 permits the collimator 1 to be rotated in a plane parallel to the camera crystal. Rotation can be manual or motorized.
The fixture 2 is shown in enlarged scale in FIG. 4 includes locking mechanism 22 which engages collimator rim 24 to permit collimator 1 to sequentially assume predetermined angular orientations. The locking mechanism 22 is further provided with detent button 26 which secures the collimator rim 24 by engaging detents 27 therein located at intervals corresponding to the predetermined angular orientations of the collimator 1. The level of engagement of collimator rim 24 by locking mechanism 22 is made adjustable by a set screw 28.
Alternatively, the collimator 1 can be allowed to rotate continuously during the image recording process.
In practice, the camera 3 is directed toward a volume of interest 30, the object to be imaged and a separate image 4 is recorded for each view 1 through N of the preset angular orientation of the collimator 1. Each image, or each gamma ray recorded must also have recorded the associated angular orientation of the collimator 1. Recording the gamma rays during continuous rotation results, in effect, in a very large set of separate images each representing an angular orientation that the collimator 1 passes through during its rotation. Alternatively, the collimator could be tilted such that the viewing angle is varied discretely or continuously during the image recording process.
Each of the resulting images 4 provides a conventional two dimensional representation of the radioisotope distribution in front of the camera-collimator. Because of the nonperpendicular angle α of the holes 20 in the collimator 1, each image depicts the volume 30 as viewed from a different orientation.
From the multiples views 1-N, a three dimensional model 5 of the isotope distribution in the volume of interest 3 is generated. This model 5 is successively "imaged" by a simulation of the camera-collimator imaging model 6 and simulated images 7 are produced. These simulated images 7 are compared 8 with the actual images 4 produced by the camera-collimator. Discrepancies 9 are used to adjust the model 5 and the entire process is repeated. This iterative process is continued until a desired degree of accuracy is reached. The resulting model is then separated 10 into planes 11 representing different distances from the collimator.
Initially, three dimensional model 5 is a three dimensional array with random or no information. Then, based on a model 6, a simulated view 1 is generated which is assumed to contain the isotope distribution that would result in a projected or two dimensional view 1 at the angular orientation of collimator that corresponds to view 1. The two views are compared at 8 and iteratively corrected. The process occurs for all N views corresponding to the N angular orientations assumed by the collimator 1.
An iterative reconstruction technique is preferred, but alternate techniques could be used including 3-dimensional Fourier reconstruction, convolution and back-projection methods and matrix inversion methods.
Iterative techniques are preferred because they can easily incorporate a priori information, non-uniform attenuation, different imaging geometries, data noise and other sources of image degradation. The preferred iterative technique is the iterative least squares method. This method chooses the reconstructed volume whose simulated images minimize the total chi square between the original views and the simulated views. During the simulated image reconstruction, the imaging model 6 considers the attenuation of the gamma rays as they pass through the object 30 prior to detection. Statistical variations in the number of gamma rays detected at each point in the actual views 4 must be considered during their comparison with the simulated views 7. The adjustments made in the model 5 minimizes the propagation of noise. Consideration is given to gamma rays originating in volumes not viewed by all viewing orientations. A priori knowledge of the usual type of volume distribution is used in weighting the modifications to the volume model.
The inventive apparatus and method is particularly well adapted for cardiac studies since a typical small field of view collimator 1 of about 9.75" diameter and 1" thickness with holes 20 at 25° slant will satisfactorily image to a depth of about 25 cm. These dimensions permit multiplanar imaging of the heart in most patients.
An alternative embodiment for the collimator 1 is to divide the collimator into several sub-collimators, each oriented such that the volume viewed by the sub-collimators overlaps. This reduces the number of images that need to be recorded since each image would in fact contain multiple non-overlapping sub-images, each providing a different view of the same volume in front of the camera.
|Cited Patent||Filing date||Publication date||Applicant||Title|
|US3011057 *||Jan 2, 1958||Nov 28, 1961||Anger Hal O||Radiation image device|
|US3612865 *||Nov 8, 1968||Oct 12, 1971||Nuclear Chicago Corp||Tomographic radiation camera|
|US4181839 *||Aug 26, 1977||Jan 1, 1980||Cardiac Medical Sciences Corp.||Multi-view collimator|
|US4197460 *||Feb 11, 1977||Apr 8, 1980||The United States Of America As Represented By The United States Department Of Energy||Multi-angle nuclear imaging apparatus and method|
|1||*||Gilbert, "Herative Methods for the Three-Dimensional Reconstruction of an Object from Projections" J. Theor. Biol. vol. 36, 1972, pp. 105-117.|
|2||*||Kuhl et al., "Image Separation Radioisotope Scanning" Radiology, vol. 80, 1963, pp. 653-662.|
|3||*||Vogel et al., "A New Method of Multiplanar Emission Tomography using a Seven Pinhole Collimator and an Anger Scintillation Camera" Journal of Nuc. Medicine, vol. 19, No. 6, 1978, pp. 648-654.|
|Citing Patent||Filing date||Publication date||Applicant||Title|
|US4532645 *||Sep 28, 1983||Jul 30, 1985||X-Cel X-Ray Corporation||Quick release and adjustable collimator device|
|US4580054 *||Mar 26, 1984||Apr 1, 1986||Elscint, Inc.||Method and apparatus for locating a point in a three-dimensional body using images of the body from a plurality of angular positions|
|US4825454 *||Dec 28, 1987||Apr 25, 1989||American Science And Engineering, Inc.||Tomographic imaging with concentric conical collimator|
|US5323006 *||May 18, 1993||Jun 21, 1994||Frederick M. Mako||Dedicated apparatus and method for emission mammography|
|US5654820 *||Apr 3, 1995||Aug 5, 1997||Iowa State University Research Foundation, Inc.||Optoelectronic system for implementation of iterative computer tomography algorithms|
|US7470906 *||Sep 21, 2006||Dec 30, 2008||Siemens Medical Solutions Usa, Inc.||Adaptive collimator for nuclear medicine and imaging|
|US7585109||Nov 21, 2007||Sep 8, 2009||X-Cel X-Ray||Arm linkage system for a radiographic device|
|US7587027||Dec 19, 2007||Sep 8, 2009||X-Cel X-Ray||Method and apparatus for determining and displaying x-ray radiation by a radiographic device|
|US7663111 *||Mar 28, 2007||Feb 16, 2010||Orbotech Ltd.||Variable collimation in radiation detection|
|US8094894||Dec 1, 2006||Jan 10, 2012||Spectrum Dynamics Llc||Radioactive-emission-measurement optimization to specific body structures|
|US8111886||Jul 19, 2006||Feb 7, 2012||Spectrum Dynamics Llc||Reconstruction stabilizer and active vision|
|US8280124 *||Jun 1, 2005||Oct 2, 2012||Spectrum Dynamics Llc||Methods of view selection for radioactive emission measurements|
|US8338788||Jun 3, 2010||Dec 25, 2012||Spectrum Dynamics Llc||Method and system of optimized volumetric imaging|
|US8423125||Oct 31, 2007||Apr 16, 2013||Spectrum Dynamics Llc||Radioimaging|
|US8445851||Oct 31, 2007||May 21, 2013||Spectrum Dynamics Llc||Radioimaging|
|US8489176||Aug 21, 2000||Jul 16, 2013||Spectrum Dynamics Llc||Radioactive emission detector equipped with a position tracking system and utilization thereof with medical systems and in medical procedures|
|US8492725||Dec 24, 2012||Jul 23, 2013||Biosensors International Group Ltd.||Method and system of optimized volumetric imaging|
|US8521253||Oct 29, 2007||Aug 27, 2013||Spectrum Dynamics Llc||Prostate imaging|
|US8545814 *||Jun 13, 2007||Oct 1, 2013||The Board Of Trustees Of The Leland Stanford Junior University||Non-invasive localization of a light-emitting conjugate in a mammal|
|US8565860||Jul 10, 2003||Oct 22, 2013||Biosensors International Group, Ltd.||Radioactive emission detector equipped with a position tracking system|
|US8571881||May 17, 2007||Oct 29, 2013||Spectrum Dynamics, Llc||Radiopharmaceutical dispensing, administration, and imaging|
|US8586932||May 9, 2007||Nov 19, 2013||Spectrum Dynamics Llc||System and method for radioactive emission measurement|
|US8606349||Oct 31, 2007||Dec 10, 2013||Biosensors International Group, Ltd.||Radioimaging using low dose isotope|
|US8610075||Nov 13, 2007||Dec 17, 2013||Biosensors International Group Ltd.||Radioimaging applications of and novel formulations of teboroxime|
|US8615405||Oct 31, 2007||Dec 24, 2013||Biosensors International Group, Ltd.||Imaging system customization using data from radiopharmaceutical-associated data carrier|
|US8620046||Jan 8, 2012||Dec 31, 2013||Biosensors International Group, Ltd.||Radioactive-emission-measurement optimization to specific body structures|
|US8620679||Oct 31, 2007||Dec 31, 2013||Biosensors International Group, Ltd.||Radiopharmaceutical dispensing, administration, and imaging|
|US8644910||Jul 19, 2006||Feb 4, 2014||Biosensors International Group, Ltd.||Imaging protocols|
|US8676292||Jan 23, 2007||Mar 18, 2014||Biosensors International Group, Ltd.||Multi-dimensional image reconstruction|
|US8748826||Jun 10, 2013||Jun 10, 2014||Biosensor International Group, Ltd.||Radioimaging methods using teboroxime and thallium|
|US8748827||Jul 22, 2013||Jun 10, 2014||Biosensors International Group, Ltd.||Method and system of optimized volumetric imaging|
|US8837793||Jan 9, 2012||Sep 16, 2014||Biosensors International Group, Ltd.||Reconstruction stabilizer and active vision|
|US8894974||May 11, 2007||Nov 25, 2014||Spectrum Dynamics Llc||Radiopharmaceuticals for diagnosis and therapy|
|US8909325||Jul 11, 2001||Dec 9, 2014||Biosensors International Group, Ltd.||Radioactive emission detector equipped with a position tracking system and utilization thereof with medical systems and in medical procedures|
|US9040016||Jul 19, 2007||May 26, 2015||Biosensors International Group, Ltd.||Diagnostic kit and methods for radioimaging myocardial perfusion|
|US9275451||Dec 20, 2007||Mar 1, 2016||Biosensors International Group, Ltd.||Method, a system, and an apparatus for using and processing multidimensional data|
|US9316743||Nov 18, 2013||Apr 19, 2016||Biosensors International Group, Ltd.||System and method for radioactive emission measurement|
|US9370333||Dec 26, 2013||Jun 21, 2016||Biosensors International Group, Ltd.||Radioactive-emission-measurement optimization to specific body structures|
|US9470801||Dec 28, 2006||Oct 18, 2016||Spectrum Dynamics Llc||Gating with anatomically varying durations|
|US20080073599 *||Sep 21, 2006||Mar 27, 2008||Vija A Hans||Adaptive collimator for nuclear medicine and imaging|
|US20080152089 *||Dec 19, 2007||Jun 26, 2008||X-Cel, X-Ray||Method and Apparatus for Determining and Displaying X-Ray Radiation by a Radiographic Device|
|US20080212734 *||Mar 9, 2006||Sep 4, 2008||Fraunhofer-Gesellschaft Zur Foerderung Der Angewandten Forschung E.V.||Correction of Non-Linearities in an Imaging System by Means of a Priori Knowledge in Radiography|
|US20080237482 *||Mar 28, 2007||Oct 2, 2008||Orbotech Medical Solutions Ltd.||Variable collimation in radiation detection|
|US20090041668 *||Jun 13, 2007||Feb 12, 2009||Contag Pamela R||Non-invasive localization of a light-emitting conjugate in a mammal|
|US20090129554 *||Nov 21, 2007||May 21, 2009||X-Cel X-Ray||Arm Linkage System for a Radiographic Device|
|US20110026685 *||Jun 3, 2010||Feb 3, 2011||Spectrum Dynamics Llc||Method and system of optimized volumetric imaging|
|DE3510692A1 *||Mar 23, 1985||Nov 28, 1985||Elscint Ltd||Verfahren und einrichtung zum lokalisieren eines punktes in einem dreidimensionalen koerper unter verwendung von abbildungen des koerpers aus einer vielzahl von winkelpositionen|
|EP0086709A1 *||Feb 9, 1983||Aug 24, 1983||COMMISSARIAT A L'ENERGIE ATOMIQUE Etablissement de Caractère Scientifique Technique et Industriel||Process and apparatus to obtain three-dimensional images of an object as applied in tomography|
|WO2006094493A2 *||Mar 9, 2006||Sep 14, 2006||Fraunhofer-Gesellschaft Zur Foerderung Der Angewandten Forschung E.V.||Correction of non-linearities in an imaging system by means of a priori knowledge in radiography|
|WO2006094493A3 *||Mar 9, 2006||Nov 16, 2006||Fraunhofer Ges Forschung||Correction of non-linearities in an imaging system by means of a priori knowledge in radiography|
|U.S. Classification||250/363.04, 378/150|
|Cooperative Classification||G01T1/2985, A61B6/037|
|Nov 18, 1981||AS||Assignment|
Owner name: TECHNICARE CORPORATION, 29100 AURORA ROAD, SOLON,
Free format text: RE-RECORD OF AN INSTRUMENT RECORDED JANUARY 21, 1980, REEL 3729 FRAME 574, TO CORRECT THE HABITAT OF THE ASSIGNEE.;ASSIGNORS:WAKE, ROBERT H.;GOTTSCHALK, STEPHEN C.;SMITH, KENDALL A.;REEL/FRAME:003920/0379
Effective date: 19800424