|Publication number||US4784157 A|
|Application number||US 07/007,678|
|Publication date||Nov 15, 1988|
|Filing date||Jan 28, 1987|
|Priority date||Feb 4, 1986|
|Publication number||007678, 07007678, US 4784157 A, US 4784157A, US-A-4784157, US4784157 A, US4784157A|
|Inventors||Justin A. T. Halls, David W. Hawes, Heinz S. Wolff, Richard D. Vahrman|
|Original Assignee||Halls Justin A T, Hawes David W, Wolff Heinz S, Vahrman Richard D|
|Export Citation||BiBTeX, EndNote, RefMan|
|Patent Citations (11), Referenced by (114), Classifications (15), Legal Events (3)|
|External Links: USPTO, USPTO Assignment, Espacenet|
This invention relates to a method and apparatus for taking samples from or administering medication to a patient, and, in a preferred form, for the continuous monitoring of a given physiological condition of an ambulatory patient.
One form of the invention is concerned simply with taking a sample from a patient without the presence of a qualified attendant, for example at a given hour of the night. A more developed form of the invention is concerned with continuous monitoring.
The continuous monitoring of certain physiological parameters in patients who are going about their normal lives has been an important advance in diagnostics over the last fifteen years. Knowledge of the effect of the stresses of actual living on for example the patient's ECG or EEG has added greatly to the clinician's capacity to understand the patient's illness and prescribe appropriate drugs.
However, it has not been possible for the clinician to follow the concentration of these drugs in the patient's blood, and relate it in detail to the changes produced in for example heart or brain action. To date, there has been no effective means of withdrawing on a regular basis a plurality of discrete samples of blood from the ambulatory patient.
Hitherto efforts have been made to draw off a sample of blood continuously, either for testing continuously or for separation into aliquots for testing. However, trouble arises over blocking of the cannula by blood clots, and the simultaneous administration of an anticoagulant has not proved feasible at the low flow rates required for an ambulatory device.
The same problems arise if it is required to take a single sample at a given time when no attendance can be provided.
The approach of the present invention in its broad aspect is to collect a discrete sample of blood or other fluid straight into an individual container: before and after sampling the whole system is emptied and flushed through, so that there is no opportunity for clotting to occur.
The invention in one aspect accordingly provides apparatus for taking a blood sample comprising
a syringe for drawing a blood sample from a manifold to be connected with the patient, and
fluid flow means to draw blood into the manifold before sampling and to flush it afterwards with anticoagulant liquid.
Preferably the fluid flow means includes
a reservoir for anticoagulant liquid and a reversible pump therefor, and
control means for the pump and syringe, whereby the pump:
(a) before sampling, pumps anticoagulant liquid slowly into the patient;
(b) for sampling, pumps blood rapidly into the manifold;
(c) after sampling, flushes the manifold rapidly with anticoagulant liquid; and thereafter
(d) again pumps anticoagulant liquid slowly into the
In a further aspect the invention provides a method of taking a blood sample from an ambulatory subject comprising:
connecting a manifold to the patient,
activating a syringe to draw a sample from the manifold, and
drawing blood from the patient into the manifold before sampling and flushing it afterwards with anticoagulant liquid.
Preferably, in the method just described, before and after sampling, anticoagulant liquid is pumped slowly into the patient; immediately before sampling blood is drawn rapidly from the vein into the manifold; immediately after sampling anticoagulant liquid is pumped into the manifold to displace the blood; and thereafter anticoagulant liquid is again pumped slowly into the subject.
For continuous monitoring of an ambulatory patient, means is provided to be carried on the patient, including a series of syringes for successively drawing blood samples from the manifold, the previously mentioned fluid flow means comprising reservoir and pump, and control means for the syringes and pump.
The pack may also include means to inject medication into the patient, which may be done in addition to or in lieu of blood sampling.
By way of example only, there may be a bank of say seven syringes which are operated successively at one hour intervals. The apparatus may be small enough to be attached to a patient's arm for periods up to a day.
In the drawings:
FIG. 1 is a diagram to illustrate the construction and method of use of a blood sampling pack embodying this invention;
FIG. 2 is a perspective view, with parts cut away, of a pack to be carried by a patient; and
FIG. 3 is a sketch illustrating the pack carried by the
Referring now to FIG. 1 in detail, a series of syringes 10 are connected to a manifold 11 which itself is connected at one end preferably by a flexible tube 9, (shown in dotted line) to a cannula 12 inserted into a vein of a patient. At the opposite end the manifold 11 is connected to a reservoir 13 of heparinised saline through a peristaltic pump 14 driven by a reversible electric motor M.
There are seven syringes 10 shown in FIG. 1. Clearly the number may be greater or smaller depending on requirements. As will be explained, the invention envisages within its scope a construction with only one syringe. While the syringes may be of any construction, each syringe is preferably constructed as described in U.S. patent application Ser. No. 007,730 filed on Jan. 28, 1987 by Heinz Siegfried Wolff and David William Hawes, for SYRINGE, the contents of which are hereby incorporated by reference.
The timing of the successive operations is preferably controlled by a microprocessor (not shown in FIG. 1) which is programmed by a key-pad (also not shown) plugged in for the purpose. Of course, other controllers may be used in lieu of a microprocessor. In general a routine program suffices, but if necessary the program can be adjusted by the investigator in charge. Typical values for a satisfactory operation are as follows:
(1) Between samples the pump 14 runs slowly in direction A and pumps herparinised saline into the vein at a rate of 2 ml/hr, to prevent the cannula from becoming occluded by clotted blood.
(2) Immediately prior to sampling at preselected intervals the pump 14 runs fast (about ten times the perfusion speed) in direction B, filling the catheter C and the manifold 11 with blood. After a period of time or number of revolutions sufficient to take the end of the blood column well past the manifold, the pump stops. Alternatively, a light sensitive device or other blood sensing means may be employed to stop the pump motor on sensing blood at a given point beyond the manifold 11.
(3) The first syringe 10 Syl operates and aspirates blood from the manifold 11 and via catheter 12 from the vein. Preferably, it stops aspirating slightly before the syringe chamber is full. This is easily accomplished if using the aforementioned Wolff et al syringe structure.
(4) Immediately after sampling by syringe Syl, the pump 14 again reverses direction, and at high speed flushes the connecting tube 9 and cannula 12 with fresh heparinised saline drawn from reservoir 13 back into the patient's vein V.
(5) Syringe Syl is reactuated, drawing in a small amount of the heparinised saline with which the manifold is now filled. This aspiration results in syringe Syl now being filled, primarily with the patient's blood to which has been added a small amount of heparinized saline to prevent clotting in syringe Syl.
(6) The system then reverts to the original condition described under (1) above. In one typical program, at preselected intervals steps 1 to 6 above will be repeated for each syringe 10.
The method and apparatus described has the following advantages:
(a) Because the blood is held only briefly in the manifold and then immediately flushed out with heparinised saline, there is no time for the blood to clot. This means not only that there is no risk of the system becoming blocked and ceasing to run but, more important, there is no risk to the patient from embolism.
(b) In the system as illustrated, up to seven samples can be taken without further attention, and further series of seven samples can be taken simply by inserting a new syringe unit. The catheter does not need to be changed for several days.
Since for most purposes hourly samples are adequate, this means that the patient does not have to return for attention for seven hours. If less frequent sampling is acceptable, or if more syringes are employed, the period between medical personnel attention is correspondingly longer.
(c) The filled syringes can be left in situ until the unit is changed.
The syringes can be pre-charged with small quantities of dry or liquid reagent which will stabilize the sample or protect the substance of interest.
Referring now in detail to FIG. 2, FIG. 2 illustrates a pack (designated generally 20) which contains certain of the parts referred to with reference to FIG. 1, but not the syringes which are separately located. In a relatively rigid casing 21 which is generally rectangular there are contained a power supply, here shown as a set of batteries 22, the reservoir 13 and pump 14 with a geared down driving motor 23 therefor. The reservoir may take the form of a flexible bag with a self-sealing cap 24 readily accessible under a removable cover (not shown) although other forms of containers may serve as reservoir 13. A tube 25 forming part of the pump 14, which is preferably of delta peristalsic type, is connected to the reservoir 13 and extends from the casing for connection to the syringe manifold 11. The casing 21 contains a controller, preferably a programmable controller such as a central processor unit and memory (not shown) settable on connection of a key pad to the microprocessor through connector 26. A syringe control cable (not shown) is connected to a socket 27, to supply power as required to a selected syringe.
The bag forming reservoir 13 may be a standard pediatric sachet of saline, with anticoagulant added through the self-sealing cap 24.
The motor M drives the perstalsic pump 14 through high reduction, and may be pulsed when extremely low speed is needed.
If required the syringes 10 (Syl-Sy7) may include one or more which, instead of aspirating to collect a sample, inject a liquid medication or the like into the manifold 11 so that when the manifold is flushed the liquid medication enters the patient. Treatment can be effected in this way. Alternatively all of the syringes may act to inject rather than aspirate in which case the invention may be employed for the programmed administration of medication. However, because of the problems of clotting in the taking of blood samples, this apparatus and method finds maximum utility in such use.
If desired, the method and apparatus described can be used to take or administer a single sample, for example at a time when medical attendance cannot be guaranteed. The apparatus does not need to be assembled into a pack for this purpose, and a single syringe may suffice.
When used as a blood sampler, the samples collected by the method and apparatus described herein need not be used exclusively or directly for the estimation of the effect of a drug. It can be equally instructive for the physician to obtain information about the concentration of a physiologically occurring substance, possibly one to be controlled by the administration of a drug, or even about the appearance or abundance of cellular constituents of the blood. For estimations of the highest accuracy, a known concentration of a marker substance can be incorporated in the flushing fluid and in any solution with which the syringes may be precharged. The concentration of this marker in the sample will then be a measure of the degree of dilution. The marker substance does not only have to be harmless, but must not occur in the body in significant amounts. There are dyes currently known and used in medical procedures which form satisfactory markers.
FIG. 3 shows how the parts of the apparatus can be located on a patient. Here, the syringes 10 are arranged as a bandolier 101 strapped to the patient's arm. Each syringe 10 is connected by a tube 102 of small diameter to the manifold 11, itself connected to a vein in the patient's arm by the cannula 12. The control unit reservoir and pump, as in FIG. 2, may be slung around the patient's body. The connecting tube 25 is shown in FIG. 3, and also a lead 104 providing the electrical connections for the syringes.
Other ways of supporting the apparatus on a patient are contemplated within the scope of this invention as defined by the claims.
While there has been described and illustrated a preferred embodiment of the present invention, it is apparent that numerous alterations, omissions and additions may be made without departing from the spirit and scope of the invention thereof.
|Cited Patent||Filing date||Publication date||Applicant||Title|
|US3043303 *||Jul 11, 1958||Jul 10, 1962||Joseph W Still||Method and apparatus for utilizing the permanent long term aorta intubation of a laboratory animal|
|US3405706 *||Apr 21, 1966||Oct 15, 1968||Paul Cinqualbre||Arrangement for taking blood|
|US3494351 *||Jun 21, 1966||Feb 10, 1970||Horn Ferrell S||Multiple vial fluid collecting device|
|US3616789 *||Mar 2, 1970||Nov 2, 1971||Systematics||Blood specimen apparatus|
|US3633566 *||May 15, 1969||Jan 11, 1972||Systematics||Blood collecting method and device|
|US3674011 *||Jan 12, 1971||Jul 4, 1972||United Medical Lab Inc||Means for and method of transfering blood from a patient to multiple test tubes within a vacuum|
|US4077395 *||Oct 12, 1976||Mar 7, 1978||St. Thomas's Hospital Medical School||Apparatus for taking blood samples from a living patient|
|US4246899 *||Oct 23, 1978||Jan 27, 1981||Loseff Herbert S||Drainage system for a collection of body fluids|
|US4385630 *||Aug 29, 1980||May 31, 1983||Haemonetics Corporation||Blood donation unit|
|US4657027 *||Jan 24, 1985||Apr 14, 1987||Ferring Biotechnik Gmbh||Means for taking blood samples for the diagnosis of bodily functions|
|EP0107579A2 *||Oct 13, 1983||May 2, 1984||LE MATERIEL BIOMEDICAL Société à Responsabilité Limitée dite:||Device for sampling physiological fluids, in particular blood, and receptacle therefor|
|Citing Patent||Filing date||Publication date||Applicant||Title|
|US4999307 *||Feb 13, 1989||Mar 12, 1991||Baxter International Inc.||Apparatus and method for periodic aseptic withdrawal of liquid samples from a sterile liquid source|
|US5134079 *||Mar 27, 1989||Jul 28, 1992||International Technidyne Corp.||Fluid sample collection and delivery system and methods particularly adapted for body fluid sampling|
|US5143084 *||Nov 16, 1990||Sep 1, 1992||Spacelabs, Inc.||Disposable cartridge for sampling and analyzing body fluids|
|US5243982 *||Jul 18, 1991||Sep 14, 1993||Avl Medical Instruments Ag||Device for determining the concentration of at least one substance in organic tissue|
|US5376079 *||Sep 30, 1992||Dec 27, 1994||Holm; Niels E.||Dispensing device for dispensing at least two fluids|
|US5411485 *||Jan 26, 1994||May 2, 1995||Hyprotek||Catheter access system and method|
|US5411490 *||Apr 20, 1994||May 2, 1995||Hyprotek, Inc.||Initialization and access system for multi-lumen central venous catheters|
|US5417667 *||Apr 18, 1994||May 23, 1995||Hyprotek, Inc.||Catheter access system and method|
|US5454792 *||Apr 18, 1994||Oct 3, 1995||Hyproteck, Inc.||Linear slide valve for CVC access|
|US5462716 *||Nov 10, 1992||Oct 31, 1995||Holm; Niels E.||Container for receiving and separating a fluid, preferably blood plasma, into its ingredients|
|US5480378 *||Aug 24, 1994||Jan 2, 1996||Weis-Fogh; Ulla||Apparatus for preparing a concentrate of coagulation factors from a blood sample|
|US5507299 *||Jun 13, 1994||Apr 16, 1996||Roland; Patricia D.||Multi-vial blood collection system|
|US5520658 *||Dec 12, 1994||May 28, 1996||E. R. Squibb & Sons, Inc.||Dispensing device for dispensing at least two fluids|
|US5603845 *||Apr 12, 1995||Feb 18, 1997||E. R. Squibb & Sons, Inc.||Liquid separation apparatus and method|
|US5658533 *||Jun 6, 1995||Aug 19, 1997||E.R. Squibb & Sons, Inc.||Container for receiving and separating a fluid into its ingredients|
|US5674458 *||Jun 6, 1995||Oct 7, 1997||E. R. Squibb & Sons, Inc.||Container for receiving and separating a fluid into its ingredients|
|US5733446 *||Dec 2, 1994||Mar 31, 1998||Bristol-Myers Squibb Company||Centrifuge with annular filter|
|US5738784 *||Dec 1, 1995||Apr 14, 1998||E.R. Squibb & Sons, Inc.||Device for separating a blood component from blood or plasma|
|US5746979 *||Jun 6, 1995||May 5, 1998||F. R, Squibb & Sons, Inc.||Method for receiving and separating a fluid into its ingredients|
|US5776336 *||Oct 31, 1996||Jul 7, 1998||Bristol-Myers Squibb Company||Annular filter assembly|
|US5785662 *||May 30, 1996||Jul 28, 1998||Medisys Technologies, Inc.||Blood collection assembly with plurality of vials|
|US5792344 *||Oct 31, 1996||Aug 11, 1998||Bristol-Myers Squibb Company||Liquid separation container for a centrifugal separator|
|US5795489 *||Nov 8, 1996||Aug 18, 1998||Bristol-Myers Squibb Company||Centrifugal filtration method|
|US5824230 *||Nov 7, 1996||Oct 20, 1998||E.R. Squibb & Sons, Inc.||Method and device for separating a component such as fibrin I from blood plasma|
|US5830352 *||Dec 1, 1995||Nov 3, 1998||Bristol-Myers Squibb Company||Centrifuge reagent delivery system|
|US5858253 *||Oct 31, 1996||Jan 12, 1999||Bristol-Myers Squibb Company||Blood separation process|
|US5871699 *||Jan 9, 1996||Feb 16, 1999||Ruggeri; Guido||Apparatus and method for drawing liquid samples and dispensing them into a plurality of test tubes|
|US5935432 *||Nov 6, 1997||Aug 10, 1999||Bristol-Myers Squibb Company||Centrifuge reagent delivery system|
|US5958253 *||Nov 6, 1997||Sep 28, 1999||Bristol-Myers Squibb Company||Centrifuge reagent delivery method|
|US6074366 *||Jan 16, 1998||Jun 13, 2000||Tandem Medical Inc.||Medication delivery apparatus|
|US6146360 *||Jan 14, 1999||Nov 14, 2000||Tandem Medical, Inc.||Medication delivery apparatus|
|US6416496||Nov 14, 2000||Jul 9, 2002||Tandem Medical, Inc.||Medication delivery apparatus|
|US6428518||Nov 5, 1999||Aug 6, 2002||Tandem Medical||Medication delivery container|
|US6585696||Dec 22, 2000||Jul 1, 2003||Baxter International, Inc.||Method and apparatus for applying a medically useful multiple component material|
|US6626863||Nov 22, 2000||Sep 30, 2003||Nusaf, L.L.C.||Safety syringe|
|US6669668||Nov 5, 1999||Dec 30, 2003||Tandem Medical||Medication delivery pump|
|US6692481||Jun 28, 2002||Feb 17, 2004||John M. Guerrero||Method and apparatus for treatment of amblyopia|
|US6726655||Nov 5, 1999||Apr 27, 2004||Tandem Medical||Medication delivery system|
|US7481787||Dec 21, 2005||Jan 27, 2009||Optiscan Biomedical Corporation||Fluid handling cassette having a spectroscopic sample cell|
|US7488309||Jul 2, 2003||Feb 10, 2009||Bioanalytical Systems, Inc.||Device and method for drug delivery to animals|
|US7615007||Mar 26, 2007||Nov 10, 2009||Dexcom, Inc.||Analyte sensor|
|US7775975||Aug 17, 2010||Dexcom, Inc.||Analyte sensor|
|US7783333||Mar 10, 2005||Aug 24, 2010||Dexcom, Inc.||Transcutaneous medical device with variable stiffness|
|US7857760||Feb 22, 2006||Dec 28, 2010||Dexcom, Inc.||Analyte sensor|
|US7885697||Feb 8, 2011||Dexcom, Inc.||Transcutaneous analyte sensor|
|US7907985||Mar 15, 2011||Optiscan Biomedical Corporation||Fluid handling cassette with a fluid control interface and sample separator|
|US8034015||Apr 28, 2008||Oct 11, 2011||Optiscan Biomedical Corporation||Anti-clotting apparatus and methods for fluid handling system|
|US8080279||Dec 4, 2007||Dec 20, 2011||Sqi Diagnostics Systems Inc.||Method for double-dip substrate spin optimization of coated micro array supports|
|US8116985||Mar 19, 2007||Feb 14, 2012||Battelle Memorial Institute||Real time sampling, monitoring and exposure control of test animals|
|US8197770||Jan 26, 2009||Jun 12, 2012||Optiscan Biomedical Corporation||Fluid handling cassette having a spectroscopic sample cell|
|US8275438||Sep 25, 2012||Dexcom, Inc.||Analyte sensor|
|US8287453||Nov 7, 2008||Oct 16, 2012||Dexcom, Inc.||Analyte sensor|
|US8298142||Oct 30, 2012||Dexcom, Inc.||Analyte sensor|
|US8348844||Jan 8, 2013||Kislaya Kunjan||Automated blood sampler and analyzer|
|US8364230||Jan 29, 2013||Dexcom, Inc.||Analyte sensor|
|US8364231||Jan 29, 2013||Dexcom, Inc.||Analyte sensor|
|US8396528||Mar 12, 2013||Dexcom, Inc.||Analyte sensor|
|US8425416||Apr 23, 2013||Dexcom, Inc.||Analyte sensor|
|US8425417||Apr 23, 2013||Dexcom, Inc.||Integrated device for continuous in vivo analyte detection and simultaneous control of an infusion device|
|US8425444||Apr 11, 2007||Apr 23, 2013||Optiscan Biomedical Corporation||Anti-clotting apparatus and methods for fluid handling system|
|US8447376||May 21, 2013||Dexcom, Inc.||Analyte sensor|
|US8449464||May 28, 2013||Dexcom, Inc.||Analyte sensor|
|US8470241||May 19, 2008||Jun 25, 2013||Optiscan Biomedical Corporation||Fluid injection and safety system|
|US8478377||Nov 7, 2008||Jul 2, 2013||Dexcom, Inc.||Analyte sensor|
|US8491501||Mar 11, 2011||Jul 23, 2013||Optiscan Biomedical Corporation||Fluid handling cassette|
|US8532730||Oct 4, 2006||Sep 10, 2013||Dexcom, Inc.||Analyte sensor|
|US8562528||Nov 7, 2008||Oct 22, 2013||Dexcom, Inc.||Analyte sensor|
|US8562558||Jun 5, 2008||Oct 22, 2013||Dexcom, Inc.||Integrated medicament delivery device for use with continuous analyte sensor|
|US8622964||Jun 20, 2008||Jan 7, 2014||Bioanalytical Systems, Inc.||Method for drug delivery to animals|
|US8626257||Nov 7, 2008||Jan 7, 2014||Dexcom, Inc.||Analyte sensor|
|US8750955||Nov 2, 2009||Jun 10, 2014||Dexcom, Inc.||Analyte sensor|
|US8774886||Oct 4, 2006||Jul 8, 2014||Dexcom, Inc.||Analyte sensor|
|US8792953||Mar 19, 2010||Jul 29, 2014||Dexcom, Inc.||Transcutaneous analyte sensor|
|US8812072||Apr 17, 2008||Aug 19, 2014||Dexcom, Inc.||Transcutaneous medical device with variable stiffness|
|US8886273||Nov 7, 2008||Nov 11, 2014||Dexcom, Inc.||Analyte sensor|
|US8911367||Mar 26, 2007||Dec 16, 2014||Dexcom, Inc.||Analyte sensor|
|US8936755||Mar 16, 2012||Jan 20, 2015||Optiscan Biomedical Corporation||Bodily fluid composition analyzer with disposable cassette|
|US8992443||Jul 19, 2013||Mar 31, 2015||Optiscan Biomedical Corporation||Fluid handling cassette|
|US9078605||Jan 6, 2014||Jul 14, 2015||Bioanalytical Systems, Inc.||Method for fluid collection from animals|
|US9125989 *||Jul 12, 2011||Sep 8, 2015||Debiotech S.A.||Device for determining the characteristics of peritoneal membrane|
|US20040024353 *||Apr 28, 2003||Feb 5, 2004||Petersen Robert L.||Method and apparatus for applying a medically useful multiple component material|
|US20040054320 *||Jul 2, 2003||Mar 18, 2004||Bioanalytical Systems, Inc.||Device and method for drug delivery to animals|
|US20060189925 *||Dec 21, 2005||Aug 24, 2006||Gable Jennifer H||Methods and apparatus for extracting and analyzing a component of a bodily fluid|
|US20060189926 *||Dec 21, 2005||Aug 24, 2006||Hall W D||Apparatus and methods for analyzing body fluid samples|
|US20060194325 *||Dec 21, 2005||Aug 31, 2006||Gable Jennifer H||Fluid handling cassette with a fluid control interface|
|US20060195045 *||Dec 21, 2005||Aug 31, 2006||Gable Jennifer H||Fluid handling cassette having a fluid transport network|
|US20060216209 *||Dec 21, 2005||Sep 28, 2006||Braig James R||Analyte detection system with distributed sensing|
|US20060235348 *||Dec 21, 2005||Oct 19, 2006||Callicoat David N||Method of extracting and analyzing the composition of bodily fluids|
|US20070060872 *||Feb 13, 2006||Mar 15, 2007||Hall W D||Apparatus and methods for analyzing body fluid samples|
|US20070179435 *||Dec 21, 2005||Aug 2, 2007||Braig James R||Analyte detection system with periodic sample draw and body fluid analyzer|
|US20070179436 *||Dec 21, 2005||Aug 2, 2007||Braig James R||Analyte detection system with periodic sample draw and laboratory-grade analyzer|
|US20080032281 *||Jun 1, 2005||Feb 7, 2008||Umedik Inc.||Method and Device for Rapid Detection and Quantitation of Macro and Micro Matrices|
|US20080131600 *||Dec 4, 2007||Jun 5, 2008||Sqi Diagnostics Systems Inc.||Method for double-dip substrate spin optimization of coated micro array supports|
|US20080161723 *||Sep 6, 2007||Jul 3, 2008||Optiscan Biomedical Corporation||Infusion flow interruption method and apparatus|
|US20080220980 *||Jul 20, 2005||Sep 11, 2008||Umedik Inc.||Method to Measure Dynamic Internal Calibration True Dose Response Curves|
|US20080255500 *||Jun 20, 2008||Oct 16, 2008||Bioanalytical Systems, Inc.||Method for drug delivery to animals|
|US20080259321 *||Jul 19, 2005||Oct 23, 2008||Umedik Inc.||System and Method for Rapid Reading of Macro and Micro Matrices|
|US20080300173 *||Jul 13, 2005||Dec 4, 2008||Defrees Shawn||Branched Peg Remodeling and Glycosylation of Glucagon-Like Peptides-1 [Glp-1]|
|US20090143711 *||Apr 28, 2008||Jun 4, 2009||Braig James R||Anti-clotting apparatus and methods for fluid handling system|
|US20090192367 *||Jul 30, 2009||Optiscan Biomedical Corporation||Analyte detection system with periodic sample draw and body fluid analyzer|
|US20110009720 *||Nov 2, 2007||Jan 13, 2011||Kislaya Kunjan||Continuous whole blood glucose monitor|
|US20110011167 *||Dec 21, 2005||Jan 20, 2011||Gable Jennifer H||Fluid handling cassette with a fluid control interface and sample separator|
|US20110175360 *||Aug 26, 2008||Jul 21, 2011||Seabased Ab||Wave-power unit|
|US20110190606 *||Aug 4, 2011||Optiscan Biomedical Corporation||Fluid handling cassette|
|US20120029325 *||Feb 2, 2012||Debiotech S.A.||Device for determining the characteristics of peritoneal membrane|
|EP0376603A1 *||Dec 20, 1989||Jul 4, 1990||Medex Incorporated||Blood sampling apparatus|
|EP2347709A2 *||Feb 13, 2006||Jul 27, 2011||Optiscan Biomedical Corporation||Body fluid analyzer|
|WO1992011881A1 *||Dec 13, 1991||Jul 23, 1992||Block Medical, Inc.||Closed system for iv site flush|
|WO2003051229A2 *||Dec 13, 2002||Jun 26, 2003||Guerrero John M||Method and apparatus for treatment of amblyopia|
|WO2003051229A3 *||Dec 13, 2002||Oct 9, 2003||John M Guerrero||Method and apparatus for treatment of amblyopia|
|WO2005082251A1 *||Feb 23, 2005||Sep 9, 2005||Datainnovation I Lund Ab||Collection of a specimen|
|WO2006007711A1 *||Jul 18, 2005||Jan 26, 2006||Umedik Inc.||Method and device to process, label and concentrate analytes|
|WO2006088771A2 *||Feb 13, 2006||Aug 24, 2006||Optiscan Biomedical Corporation||Apparatus and methods for analyzing body fluid samples|
|WO2006088771A3 *||Feb 13, 2006||Jan 25, 2007||Braig James R||Apparatus and methods for analyzing body fluid samples|
|U.S. Classification||600/575, 604/191, 604/66|
|International Classification||A61M5/168, A61B5/155, A61M5/14|
|Cooperative Classification||A61B5/15003, A61B5/150229, A61M5/16827, A61M5/1408, A61B5/150992, A61B5/1427|
|European Classification||A61B5/14B8, A61M5/14B1, A61M5/168A11|
|Jun 16, 1992||REMI||Maintenance fee reminder mailed|
|Nov 15, 1992||LAPS||Lapse for failure to pay maintenance fees|
|Jan 26, 1993||FP||Expired due to failure to pay maintenance fee|
Effective date: 19921115