|Publication number||US4809707 A|
|Application number||US 06/722,772|
|Publication date||Mar 7, 1989|
|Filing date||Apr 12, 1985|
|Priority date||Apr 12, 1985|
|Publication number||06722772, 722772, US 4809707 A, US 4809707A, US-A-4809707, US4809707 A, US4809707A|
|Inventors||Thomas L. Kraft, Howard A. Vick, James W. Meador, Corrine Johnson|
|Original Assignee||Kvm Engineering, Inc.|
|Export Citation||BiBTeX, EndNote, RefMan|
|Patent Citations (16), Non-Patent Citations (4), Referenced by (26), Classifications (8), Legal Events (7)|
|External Links: USPTO, USPTO Assignment, Espacenet|
This invention relates to an electrode for allergy testing and more particularly an electrode of the type for non-invasively providing an allergen transcutaneously into the patient's body and thereafter automatically determining whether an allergic reaction has occurred and the degree of any such reaction.
Testing for allergies has been the standard medical technique for many years. In recent years it has become more important as many patient disorders have been found to be based on some type of allergic response. Traditionally, testing for allergies have included the traditional skin test and more recently the RAST test. The traditional skin test is exemplified by either a scratch test or a needle injection test. In either case, the skin is fractured and an allergen substance of the allergy being tested is placed on the skin puncture. Where an allergic reaction occurs, the area around the puncture swells and turns a reddish color. Generally, the degree of the allergic reaction is measured by measuring the diameter of the wheal or red mark on the skin. However such measurement is only semi quantitative in that different reactions quantitatively do not generate sufficient differences in the diameter of the wheal in all instances. The RAST test is widely used where the allergy is a IgE mediated allergy. This type of test is very expensive and is performed on the blood serum.
Both of the prior art types of testing have several draw backs. First and foremost with respect to the traditional skin test some patients risk infection, undergo great pain and even can go into shock as a result of an allergic reaction to the injected allergen. This risk can of course be reduced by utilizing very small amounts of allergen, but then many allergic reactions will not occur. Thus, it will be necessary to perform the traditional skin test a multitude of times with increasing amounts of allergen. Such a solution is both expensive and painful to the patient as well as time consuming. Other disadvantages of course, are the pain the patient suffers generally both as a result of the testing procedure due to puncturing the skin as well as the resulting allergic reaction wheal which is formed.
It is known in the prior art that each allergic reaction wheal causes a slight rise in the skin temperature in the area of the wheal. Thermographic techniques have been used in the past to diagnose an allergic reaction in certain patients. However, these tests have not been entirely satisfactory because quantitative results are not available since the thermography technique can only detect the presence or absence of an allergic reaction. In addition, a significant investment in large equipment is necessary in order to perform the thermography. Lastly, the same pain and over reaction disadvantages exist as in the traditional testing procedures. Such a thermographic technique is described in the Journal of Clinical Immunology, November 1972, Vol. 50, No. 5 by Chintana Sphipatonakul, M.D. and Raymond G. Slavin, M.D., both of Saint Louis, Mo.
It would be preferable to eliminate many of these risks, undesirable pain and expense, as well as to generate a more reliable qualitative determination of the degree of the allergic reaction.
In accordance with one aspect of this invention there is provided an electrode for measuring temperature dependent reactions on the skin of the patient comprising a base, and temperature pick up means affixed to the base at a position adapted to be placed in contact with the skin. In addition, the electrode includes transducer means juxtaposed to the temperature pick up means for converting the temperature of the pick up means to an electric signal and electric lead means coupled to the transducer means and adapted for electrical connection to processor means for carrying the electric signal manifesting the skin temperature to the processor means for processing.
In accordance with another aspect of this invention there is provided an allergen delivery system for transcutaneously delivering an allergen to a patient undergoing allergy testing comprising means for containing an allergen, one side of which is adapted to contact the skin of the patient and a charge plate contacting the other side of said allergen containing means. In addition the system includes means for providing an electric charge to the charge plate, whereby the allergen transcutaneously delivered to the patient.
One preferred embodiment of the present invention is hereafter described with specific reference being made to the following figures, in which:
FIG. 1 shows the allergy testing system of the present invention attached to the back of the patient;
FIG. 2 shows a enlarged view of the bottom of the allergy testing electrode;
FIG. 3 shows a view taken across lines 3--3 of FIG. 2;
FIG. 4 shows a view taken across line 4--4 of FIG. 1; and
FIG. 5 shows a block diagram of the electronic system used in conjunction with the electrode of the subject invention.
Referring now to FIG. 1, allergy testing system 10 is shown as including an allergy testing electrode 12 and allergy testing unit 14. Unit 14 includes a start switch 16 and is coupled to electrode 12 by a temperature sensing lead 18 and a charging lead 20. Electrode 12 may be placed at any convenient place on a patient 22 such as the back as shown in FIG. 1 or the arm or other areas on which it is desired to perform an allergy test. Electronic unit 14 may be held around the patient's waist by a belt 24 or may rest in the patient's lap.
As will be explained in more detail hereafter, electrode 12 is prepared and placed on patient 22 at the desired place. Wires 18 and 20 are then connected to electronic unit 14 and switch 16 is depressed. The patient is then sent to the waiting room to wait. Approximately fifteen minutes later, the testing is completed and unit 14 is disconnected from electrode 12 and returned to the doctor. Electrode 12 is then removed from the patient and the test is concluded. Thereafter, an output means may be coupled to unit 14 to provide the results of the test to the physician for review.
Referring now to FIG. 2, the bottom side of electrode 12 is shown. The bottom side is that side which is placed directly against the skin of patient 22. Electrode 12 includes a plurality, for instance eight, of allergy testing electrodes 26 and a single common electrode 28. Each of the allergy testing electrodes 26 includes both means for delivering an allergen transcutaneously to the patient and temperature sensing means for sensing the skin temperature in the area surrounding the position where the allergen was delivered. Common electrode 28 only includes means to sense the temperature of the skin in an area where no allergen was delivered; thus, common electrode 28 senses the normal skin temperature of patient 22. Each of the allergy testing electrodes 26 and common electrodes 28 are connected to both leads 18 and 20. Lead 18 may be a plurality of individual wires, a different one of which is coupled to each of the electrodes 26 and 28 in a manner to be described in more detail hereafter. Lead 20 consists of two wires, one of which is at ground and the other of which carries a positive voltage. Both of the wires of lead 20 may be coupled to each of the allergy testing electrodes 26.
Referring now to FIG. 3, the detailed construction of one embodiment of the allergy testing electrodes 26 is shown, it being understood that each of the other electrodes 26 is substantially identical in construction. Each of the electrodes 26 is contained in a common housing 30, which is a part of electrode 12. Housing 30 may be a generally soft material and is both an electrical and thermal insulator. On the bottom of electrode 26 a thin film thermal equilibrium ring 32 is positioned within a thermally insulating base 34. Both ring 32 and base 34 may be annular rings having a center opening therein. Ring 32 is selected to be a type which can withstand the effects of solvents such as alcohol, generally associated with testing. It further should be a type which can have materials soldered, welded, or bonded thereto. It has been found that ceramic, platinum alloys and stainless steel are sufficient for this purpose. Base 34 may be any of a variety of well known heat insulating plastic materials. Base 34 should be generally rigid so to adequately support the thin film temperature equilibrium ring 32. Ring 32 may be either vacuum deposited over base 34 or may be an integral member secured thereto by gluing or other adhesive techniques.
A thermister 36 is soldered or fastened conductively to ring 32 through a hole 37 in base 34. A bonding material 38 such as electrically insulating and thermally conducting epoxy, is placed within the hole 37 to thermally bond thermister 36 with ring 32. The solder also thermally bonds thermister 36 with ring 32. A pair of leads from wire 18 is coupled to the leads from thermister 36. As is well known in the art a thermister is a type of resistor which has a decreasing resistance as the temperature of the surrounding area increases. Thus a thermister can be coupled in circuit with other electronic components and a signal can be generated having a voltage proportional to the temperature of the surrounding area. It also is possible to replace thermister 36 with a thermocouple which operates by providing a voltage based on the difference in temperature between the two ends thereof.
A charge plate 40 and removable allergen pad 42 are placed within the center opening of the annular ring 32 and base 34. Also within the center opening of ring 32 is an annular ring negative electrode 80, electrically insulated from charge plate 40 and pad 42 by annular ring insulator 82 and from ring 32 by annular ring insulator 84. Charge plate 40 is coupled to the voltage carrying wire from charging lead 20 and negative electrode 80 is coupled to the ground lead of wire 20. A charge of between 1.0 and 4.0 milliamperes may be provided over lead 20 to charge allergen pad 42. Allergen pad 42 may be a porus material into which a dry allergen is impregnated. Prior to use, a drop of distilled water may be placed on allergen pad 42 to hydrolize pad 42. When pad 42 is placed in contact with the skin of patient 22 and plate 40 receives a charge from lead 20, the allergen contained within pad 42 is transcutaneously delivered beneath the skin of patient 22. An electric field is established between charge plate 40 and negative electrode 80. This electric field penetrates through the skin of patient 22 as it flows from plate 40 to electrode 80. The charged allergen molecules migrate through the pores of the skin as the electric field traverses the skin. It should be noted that it is unnecessary to create any break in the skin of the patient 22 using the technique of allergen delivery.
Pad 42 may be made removable from the area in which it is shown. In such case, electrode 12 may be continually reused for testing by merely placing new pads 42 with the desired allergen therein.
The edges of electrode 12 are covered with a double sided tape 46 which can be used to affix electrode 12 to the desired area on patient 22. Tape 46 may be specially fabricated to fit over all non-electrode areas shown in FIG. 2 of electrode 12 so that each of the electrodes 26 and 28 are firmly attached against the skin of patient 22.
Referring now to FIG. 4, after the allergen has been transcutaneously delivered to the skin of patient 22, a reaction will occur if the patient is allergic to the allergen. As seen in FIG. 4, the skin 48 of the patient 22 swells to a wheal 50 in the area of the reaction. Wheal 50 may be a slight puffiness or reddening of the skin and generally increases in temperature. It has been found that the greater the temperature increase the greater the reaction. Further, the greater the reaction, the larger the size of wheal 50 and the brighter the redness in wheal 50. In FIG. 4, the sensor ring 32, and charge plate 40 and allergen pad 42 have been shown in dashed lines to show their positioning with respect to wheal 50. From Figuire 4 it is seen that the increased temperature of the skin 48 at wheal 50 can be sensed by sensor ring 32. The temperature profile of the wheal is such that the temperature maximum occurs at the center and tapers lower radially outward. The position of thermister 36 is at the shoulder of the temperature curve. Hence it is important for ring 32 to be low in mass and high in temperature conductivity, so as to reach an equilibrium point.
This temperature can be converted to an electrical signal by thermistor 36 and applied over the leads of lead 18 to electronic unit 14. A similar sensing of a normal skin temperature occurs at common electrode 28 which provides a signal over the wires of lead 18 to electronic unit 14 manifesting a normal skin temperature. By applying both signals to a differential amplifier, the difference in temperature can be easily obtained. By taking the measurement at periodic intervals, not only can the difference in temperature be obtained, but the change in temperature over time can be indicated. Thus, the physician utilizing the allergy testing system 10 can determine the degree of reaction by looking at how fast and how high the temperature rises. In order to avoid any contributive infra-red heating imparted by the electric fields created to drive the allergen into the skin, the field should be completed before the thermal measurements are taken. Alternatively, the field may be cycled on and off during the test and measurements taken during the off times. For example, the field may be on for one minute out of five and thermal readings taken during the four minute off time.
The physician can also utilize various ones of the allergy testing electrodes 26 shown in FIG. 2 for the same allergy test by putting different concentrations of the same allergen in various pads 42 and inserting them in different allergy testing electrodes 26. By doing this the physician can see the rate of increase of the reaction for different concentrations of allergen and can make a better diagnosis as to the treatment of the patient. Further, by retaining the record of the data, the physician can modify treatment as necessary by continually testing the patient's reaction at different times during the term of the treatment.
For slow reacting allergens, the physician may instruct the patient to wear the device for many hours. After a period prescribed by the physician, the unit 14, can be returned to the physician for analysis and diagnosis. This unique capability has not previously been possible.
Referring now to FIG. 5, a block diagram of electronic unit 14 is shown. The heart of electronic unit 14 is a microprocessor 52 which contains therein onboard random access memory (RAM) 54. Attached to microprocessor 52 in a conventional manner is program memory 56 which may be contained in a read only memory (ROM). Switch 16, shown in FIG. 1, is coupled to the interupt (INT) input of microprocessor 52 to initiate the action of microprocessor 52. Depression of switch 16 causes microprocessor 52 to make predetermined number, e.g. thirty, skin temperature readings from each of the eight testing electrodes 26 during the testing period, e.g. the next fifteen minutes. The exact time of each of the readings is determined by a clock 58 which has one input coupled to the RESET input of microprocessor 52.
Each of the nine pairs of wires of lead 18 are provided from electrodes 12 to multiplexer/amplifier (MUX/AMP) 60. Multiplexer/amplifier 60 may consist of one differential amplifier each having a lead from common plate 44 attached as one input thereof and a different one of the leads from an electrode 26 attached as the other input thereof. The output of each of the differential amplifier will be a signal the amplitude of which manifests the difference in temperature of an area under test to the normal skin temperature and those areas. Where there is very little or no reaction, the amplitude of such a signal would be very low, whereas for those areas where a significant allergic reaction occurs, the amplitude of the signal will be much greater.
The multiplexer portion of multiplexer/amplifier 60 is controlled by microprocessor 52 to select one of the electrode signals as the differential amplifier input signals and provide the difference as an output of multiplexer/amplifier 60. The output selected from multiplexer/amplifier 60 is provided an analog input to analog to digital converter 62 which converts the analog voltage provided thereto in it to a digital signal which in turn is provided to microprocessor 52. Microprocessor 52 then notes the time at which the signal is provided and stores it in an appropriate place in random access memory 54.
After all of the data has been obtained by microprocessor 52, and stored in memory 54, it can be extracted from microprocessor 52 through output buffer 64 and connector 66. Output buffer 64, for instance, may be connected to one of the input/output ports of microprocessor 54 and connector 66 may have the output of buffer 64 as well as certain control signals from microprocessor 52 connected thereto. An output device, such as a dot matrix printer 68, may be connected to connector 66 to print the data output from RAM 54. Alternatively, a terminal display unit may be connected to connector 64 or any other type of output means which is capable of displaying the data in a fashion desirable to the physician.
Power supply 70 is used to provide power to each of the various units in electronic unit 14. In addition, power supply 70 provides the electric charge over lead 20 to the charge plate 40 in the allergy testing electrodes 26 and to the negative annular ring 80 of each electrode. Because electronic unit 14 is desired to be portable, power supply 70 typically will be a battery. In order to conserve energy a second signal is provided from clock 58 which lasts for the duration of each of the individual test readings. This may only be a few milliseconds in length. During the provision of the second signal over lead 72 from clock 58, e.g. the analog to digital converter 62 and the multiplexer/amplifier 60 are energized; during other periods of time they are de-energized so that they do not draw additional power from power supply 70. The same signal over lead 72 is also applied to de-energize program memory 56 except during the critical time during which testing is done. By selecting the components contained in electronic unit 14 to be constructed of CMOS fabrication technology, a minimum drain on power supply 70 occurs except during the period of testing. As previously indicated, this testing period occurs only for a few milliseconds every thirty seconds. By selecting power supply 70 to be a lithium type battery commonly used in cardiac pacemakers, the life of electronic unit 14 can be many years.
A more detailed description of electronic unit 14 and the technique of diagnosing the allergic reaction is given in commonly assigned U.S. patent Ser. No. 722,798 filed Apr. 12, 1985 now abandoned.
|Cited Patent||Filing date||Publication date||Applicant||Title|
|US2235436 *||Nov 3, 1939||Mar 18, 1941||Stanley V Laub||Medical appliance|
|US2298506 *||Jan 25, 1940||Oct 13, 1942||Karl Binkovitz||Method for exploring living tissue|
|US2301536 *||Feb 9, 1940||Nov 10, 1942||Hill Charles H||Threshing machine cylinder and concave|
|US2304817 *||Jul 19, 1941||Dec 15, 1942||Grozin Maurice||Patch test|
|US3699813 *||May 25, 1970||Oct 24, 1972||Anthony H Lamb||Medical thermographic diagnostic means|
|US4135514 *||Mar 9, 1977||Jan 23, 1979||Alza Corporation||Osmotic releasing system for administering ophthalmic drug to eye of animal|
|US4141359 *||Aug 16, 1976||Feb 27, 1979||University Of Utah||Epidermal iontophoresis device|
|US4148005 *||Oct 14, 1977||Apr 3, 1979||The United States Of America As Represented By The Secretary Of The Army||Thermometric transducer device|
|US4211222 *||Sep 8, 1978||Jul 8, 1980||Robert Tapper||Iontophoretic burn-protection method|
|US4214592 *||Dec 29, 1977||Jul 29, 1980||Institut Merieux||Patch for skin tests|
|US4312332 *||Apr 25, 1980||Jan 26, 1982||Cordis Corporation||Oxygen sensing|
|US4402311 *||Mar 19, 1980||Sep 6, 1983||Olympus Optical Co., Ltd.||Endoscope for medical treatment|
|US4474570 *||Jul 8, 1982||Oct 2, 1984||Kabushikikaisya Advance Kaihatsu Kenkyujo||Iontophoresis device|
|US4509531 *||Jul 28, 1982||Apr 9, 1985||Teledyne Industries, Inc.||Personal physiological monitor|
|DE2826391A1 *||Jun 16, 1978||Jan 3, 1980||Heribert Ing Grad Czerny||Mother and child birth monitor - has capsule with electrodes and containing data emitter for mother and child|
|GB2076963A *||Title not available|
|1||"Performance of a Spin Evaporimeter" by A. E. Wheldon et al; Med. & Biol. Eng. & Comput., Mar. 1980, vol. 18, pp. 201-205.|
|2||"The Use of Differential Skin Temperature Measurements in the Evaluation of Post Traumatic Oedema Control" by H. Hambury et al., Med. & Biol. Eng., vol. 13, No. 2, pp. 202-208.|
|3||*||Performance of a Spin Evaporimeter by A. E. Wheldon et al; Med. & Biol. Eng. & Comput., Mar. 1980, vol. 18, pp. 201 205.|
|4||*||The Use of Differential Skin Temperature Measurements in the Evaluation of Post Traumatic Oedema Control by H. Hambury et al., Med. & Biol. Eng., vol. 13, No. 2, pp. 202 208.|
|Citing Patent||Filing date||Publication date||Applicant||Title|
|US5002527 *||Dec 6, 1988||Mar 26, 1991||Inventor's Funding Corp. Ltd.||Transdermal drug delivery applicators|
|US5053001 *||Sep 6, 1989||Oct 1, 1991||Inventor's Funding Company Ltd.||Transdermal drug delivery device with multiple reservoirs|
|US5167616 *||Dec 14, 1989||Dec 1, 1992||Alza Corporation||Iontophoretic delivery method|
|US5413113 *||Mar 21, 1994||May 9, 1995||Milne; Robert D.||Electronic allegro-sensitivity test device|
|US5634895 *||Jun 7, 1995||Jun 3, 1997||Cormedics Corp.||Apparatus and method for transpericardial delivery of fluid|
|US5897505 *||May 13, 1997||Apr 27, 1999||Feinberg; Barry I.||Selective tissue conductance/thermography sensor apparatus|
|US6629932 *||Jan 10, 2001||Oct 7, 2003||Pearl Technology Holdings, Llc||Allergen and irritant measuring device|
|US6961609 *||Nov 7, 2002||Nov 1, 2005||George Dechev||Quantitative titration of the autonomic nervous system|
|US7798976 *||Jan 16, 2003||Sep 21, 2010||Chemotechnique Mb Diagnostics Ab||Epicutaneous test plaster|
|US8191403||Mar 27, 2008||Jun 5, 2012||Richmond Chemical Corporation||Petroleum viscosity measurement and communication system and method|
|US8715203 *||Sep 17, 2007||May 6, 2014||Novocure Limited||Composite electrode|
|US8764675 *||Mar 8, 2013||Jul 1, 2014||Novocure Ltd||Composite electrode|
|US20050043648 *||Jan 16, 2003||Feb 24, 2005||Niklasson Bo Johan Niklas||Epicutaneous test plaster|
|US20070093787 *||Sep 29, 2006||Apr 26, 2007||Transcutaneous Technologies Inc.||Iontophoresis device to deliver multiple active agents to biological interfaces|
|US20070117217 *||Jun 9, 2006||May 24, 2007||The Regents Of The University Of California||Large scale parallel immuno-based allergy test and device for evanescent field excitation of fluorescence|
|US20080011058 *||Mar 19, 2007||Jan 17, 2008||The Regents Of The University Of California||Piezoresistive cantilever based nanoflow and viscosity sensor for microchannels|
|US20080289400 *||Mar 27, 2008||Nov 27, 2008||Richmond Chemical Corporation||Petroleum viscosity measurement and communication system and method|
|US20090076366 *||Sep 17, 2007||Mar 19, 2009||Yoram Palti||Composite Electrode|
|USD761427||Dec 11, 2014||Jul 12, 2016||Research Institute At Nationwide Children's Hospital||Medical marking apparatus|
|DE29700578U1 *||Jan 15, 1997||Mar 20, 1997||Baermann Horst Rheinmagnet||Pflaster zur transdermalen Applikation von Wirkstoffen|
|EP0714027A3 *||Nov 1, 1995||Dec 17, 1997||Quintsysteme für holopathische Medizin Ges.m.b.H.||Apparatus and method for registering energetic information that is specific to substances and the body|
|WO1995034243A1 *||Jun 15, 1995||Dec 21, 1995||Maitreya Corporation Limited||Apparatus and method for detecting the reaction of a subject to a plurality of substances|
|WO1996035471A1||May 8, 1995||Nov 14, 1996||Robert Drew Milne||Electronic allergo-sensitivity test device|
|WO2002091347A1 *||May 2, 2002||Nov 14, 2002||Interactive Imaging Systems, Inc.||Portable computing device|
|WO2006067217A2 *||Dec 22, 2005||Jun 29, 2006||Novo Nordisk A/S||Sensor system and method for detecting problems with mounting of skin mountable medical devices|
|WO2006067217A3 *||Dec 22, 2005||Feb 22, 2007||Peter Christian Klitgaard||Sensor system and method for detecting problems with mounting of skin mountable medical devices|
|U.S. Classification||600/549, 600/556, 604/20|
|Cooperative Classification||A61B5/441, A61B5/411|
|European Classification||A61B5/41B, A61B5/44B|
|Jul 1, 1985||AS||Assignment|
Owner name: KVM ENGINEERING, INC. 9431 ROARK ROAD HOUSTON, TX
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST.;ASSIGNORS:KRAFT, THOMAS L.;VICK, HOWARD A.;MEADOR, JAMES W.;REEL/FRAME:004427/0912
Effective date: 19850410
|Jan 27, 1988||AS||Assignment|
Owner name: DYNATECH CORPORATION, 3 NEW ENGLAND EXECUTIVE PRK,
Free format text: SECURITY INTEREST;ASSIGNOR:KVM BIOTECHNOLOGY, INC.;REEL/FRAME:004823/0092
Effective date: 19871210
Owner name: DYNATECH CORPORATION, A MA CORP.,MASSACHUSETTS
Free format text: SECURITY INTEREST;ASSIGNOR:KVM BIOTECHNOLOGY, INC.;REEL/FRAME:004823/0092
Effective date: 19871210
|Mar 21, 1990||AS||Assignment|
Owner name: KVM ENGINEERING, INC., A TX CORP., TEXAS
Free format text: RELEASED BY SECURED PARTY;ASSIGNORS:DYNATECH CORPORATION;DYNATECH LABORATORIES, INC.;REEL/FRAME:005271/0986
Effective date: 19900301
Owner name: KVM BIOTECHNOLOGY, INC., A DE CORP., DELAWARE
Free format text: RELEASED BY SECURED PARTY;ASSIGNORS:DYNATECH CORPORATION;DYNATECH LABORATORIES, INC.;REEL/FRAME:005271/0986
Effective date: 19900301
|Oct 6, 1992||REMI||Maintenance fee reminder mailed|
|Oct 14, 1992||REMI||Maintenance fee reminder mailed|
|Mar 7, 1993||LAPS||Lapse for failure to pay maintenance fees|
|May 18, 1993||FP||Expired due to failure to pay maintenance fee|
Effective date: 19930307