|Publication number||US4902291 A|
|Application number||US 07/286,620|
|Publication date||Feb 20, 1990|
|Filing date||Jan 31, 1989|
|Priority date||Jan 31, 1989|
|Publication number||07286620, 286620, US 4902291 A, US 4902291A, US-A-4902291, US4902291 A, US4902291A|
|Inventors||Willem J. Kolff|
|Original Assignee||University Of Utah Research Foundation|
|Export Citation||BiBTeX, EndNote, RefMan|
|Patent Citations (3), Referenced by (101), Classifications (9), Legal Events (6)|
|External Links: USPTO, USPTO Assignment, Espacenet|
1. Field of Invention:
The present invention relates to artificial ventricles for use as part of a total artificial heart for implantation within a living being as part of its circulatory system. More specifically the present invention relates to an artificial ventricle which can be easily positioned and surgically implanted within the patient.
2. Prior Art:
The successful advent of the total artificial heart has offered new options for extending life of patients who are awaiting heart transplants or to provide a permanent replacement if a donor heart is not available. The need for such artificial hearts is critical in view of the limited availability of donor hearts (no more than 2,000 donor hearts are available per year) as compared to the patient demand for such transplants exceeding 33,000 per year in the United States alone. Whereas terminal patients who might otherwise have little hope for survival because of the great shortage of donor hearts have little hope except as may be provided by total artificial heart systems, greatly increased attention has been given to improving such devices to overcome the myriad of technical hurdles associated with mechanically replicating the structure and performance of the natural human heart. One of the greatest challenges in connection with improving this field of technology is reduction in size of the total artificial heart and its supporting component structure to adapt to the limited physical space within the chest cavity and for its implantation. The implantation procedure requires physical space to suture the artificial atrium, aorta and pulmonary artery to their natural counterparts. Failure to achieve proper suturing of junctions with the soft tissue of the circulatory system would be a major cause of hemorrhage (bleeding), breaking of suture lines causing dehiscence and thrombogenesis.
Unfortunately, a mere reduction in size of the artificial ventricle is not a solution to the problem. Minimum stroke volumes are required to maintain adequate blood flow to support life systems of the human body. Accordingly, the artificial heart must have sufficient cavity volume to enable adequate stroke volume for pumping blood through the circulatory system. To date, man's technology has been unable to duplicate the compactness, the softness and pliability and efficiency of the natural human heart with total artificial heart systems.
The Jarvik-7 total artificial heart is characteristic of prior art devices within this general field of technology. Specifically, their ventricles are of singular construction and include a rigid casement which includes a blood flow compartment and pumping compartment. These compartments are separated by one or more diaphragms which alternately extend and contract in response to a fluid drive system which alternates between positive and negative pressure within the pumping compartment. Because of the difficulty of suturing the artificial heart and attached valve structure within the chest cavity, quick-connect couplers were developed to be sutured to the atrium, aorta and pulmonary arteries before attachment of the artificial ventricles. This provided some room for the surgeon to work within the limited chest cavity space. Once the quick connect couplers were sutured to the soft tissue of the circulatory system, the artificial ventricles would then be quick coupled at their valve openings or with their artificial atria, aorta and pulmonary artery to their natural counterpart within the chest cavity.
Unfortunately, special equipment is required for testing the suture lines. After connection of the rigid ventricle, these suture lines are difficult to reach. The quick connects enhance the risk of thrombogenesis at the quick coupling sites and even more so if the valves are incorporated in them.
Because of these and other limitations, widespread use of the total artificial heart is still limited. What is needed is artificial ventricles which are more easily implanted and which do not impose the severe spacial restraints which result from the rigid artificial hearts of the prior art.
It is therefore an object of the present invention to provide an artificial ventricle which ca be surgically implanted without the need of quick connects and which enables evaluation of complete suturing and other operational aspects of the ventricle prior to functional operation of the artificial heart.
It is a further object of the present invention to provide artificial ventricles which can be compressed or reduced in size to much smaller volume to facilitate working room for the surgeon during suturing and implantation.
It is a still further object of the present invention to separate the soft ventricle structure from the more rigid pumping structure of a total artificial heart to simplify implantation procedures.
These and other objects are realized in an artificial ventricle which comprises a soft and flexible blood pumping sac which incorporates an extended or diastolic configuration and a contracted or systolic configuration provided by wall structure having sufficient size to develop adequate stroke volume for sustaining life within the living being. The blood sac is characterized by sufficient flexibility to collapse to a substantially flattened or rolled up structure of reduced size to facilitate surgical implantation within the restricted space of the chest cavity. The ventricle includes an inlet port positioned within the wall structure and including means for attachment to the atrium or other soft tissue of the circulatory system, along with means for receiving a one way valve to control blood flow. An outlet port is also positioned within the wall structure and includes means for attachment to the aorta, pulmonary artery or other soft tissue of the circulatory system to form a continuous flowline therewith. A one way valve is also provided with respect to the outflow (flow) port to enable unidirectional blood flow in response to pumping activity of the ventricle. The present invention also includes a semi-rigid shell which is structurally separate from the blood pumping sac and includes closure means for developing closed and open configurations which respectively permit insertion around and removal from the blood pumping sac in the chest cavity. The closure means and shell provide a closed shell configuration which is slightly larger in shape and size at its interior surface than the extended configuration of the wall structure of the blood pumping sac and is structured to totally close the sac in a confining manner. This shell includes an opening for the inlet and outlet ports and sealing means to provide a circumferential seal at junctures of the shell with the respective inlet and outlet ports. The closure means of the shell also provides an open configuration which enables insertion of the contracted sac through a shell opening or removal of the shell from around the sac without affecting attachment of the sac as part of the circulatory system. Pumping means are coupled through the rigid shell to enable alternating extension and collapse of the blood pumping sac in recurring pumping manner when the shell is in the closed configuration to thereby allow inflow and expulsion of blood from the blood sac.
Other objects and features of the present invention will be apparent to those skilled in the art based on the following description, taken in combination with the accompanying drawings.
FIG. 1 shows a perspective view of the two components of the present invention including a soft and flexible artificial ventricle at the left and a semi-rigid shell structure at the right which encloses around the ventricle.
FIG. 2 is a cross section of the ventricle shown in FIG. 1, taken along the lines 2--2.
FIG. 3 is a cross section of interconnecting bridge structure and the inlet and outlet ports taken along the lines 3--3.
FIG. 4 is a cross section of the shell structure of FIG. 1, taken along the lines 4--4.
FIG. 5 is a graphic representation representing enclosure of the blood sac within the rigid shell.
FIG. 6 graphically illustrates a sequential step in the attachment of the rigid shell around the blood sac.
FIG. 7 illustrates the closed position of the shell around the blood sac, with a pumping compartment of the shell somewhat extended in response to pumping fluid pressure.
FIG. 8 illustrates another embodiment of the present invention wherein two ventricles are combined within a single construction and wherein the view corresponds to a cross section of the bridging structure and openings to the blood sac as illustrated in FIG. 3.
FIG. 9 is a graphic representation of the single construction artificial heart with a pair of enclosing shells coupled to a common separating wall.
FIG. 10 illustrates separation of the shells to enable insertion or withdrawal of the respective ventricles comprising the artificial heart system.
Referring now to the drawings:
FIG. 1 shows a generic form of the subject invention which includes two basic components. The first component is a blood pumping sac 11 and a second component is a semi-rigid shell 12 which is configured to fit snugly around the blood sac 11 when it is in its fully extended configuration as shown in FIG. 1. Specifically, the blood sac 11 includes two positions, one for the diastolic or extended configuration when the blood sac is filled with blood during a pumping cycle, and a second contracted configuration representing the systolic phase wherein the contained blood has been expelled by reason of the reduced volume of the blood sac. It will be apparent that the blood sac must have wall structure of sufficient size in containment to develop adequate stroke volume for sustaining life within the living being depending upon blood circulation by reason of this device. In addition, the blood sac needs to have sufficient flexibility to collapse to a substantially flattened or rolled up soft structure of reduced size as shown by the phantom lines 13 of FIG. 2. This much reduced size permits ease of surgical implantation within the restricted space of the chest cavity.
This blood sac 11 provides a fully enclosed cavity except for an inlet port 14 and outlet port 15. The inlet port is positioned within the wall structure 16 and includes an atrial cuff 17 or other means for attachment to the atrium or other soft tissue of the circulatory system to form a continuous flowline 18 therewith. The inlet port 14 would also include some form of one way valve 19 for insuring proper direction 18 of blood flow into the ventricle.
The outlet port 15 likewise includes a one way valve 20 or means for receiving such a valve to control unidirectional blood flow. The outlet port is positioned within the wall structure 16 of the blood sac and includes a graft 21 or other means for attachment to the aorta, pulmonary artery or other soft tissue within the circulatory system to close the required blood flow line.
The preferred construction of the blood sac 11 is a thin walled structure of silicon or Silastic (trademark registered to Dow Corning) or polyurethane material. This polymer should be soft and flexible to enable its collapse to a flat or rolled configuration 13 so that the blood sac takes up minimal space within the chest cavity during implantation. The present inventor has discovered that current silicon materials provide surprising and unexpected adaptability for use as an artificial ventricle, despite lack of application in this area in the last ten years. Silicon does have the benefit of being nonbiodegradable and the inventor has discovered certain silicon materials that have sufficient strength to provide the survivability required for use as part of an artificial heart. This new silicon material is identified under the tradename of Silastic HP-100 and has proven particularly suited for this application based on laboratory tests to date. Specifically, HP-100 Silastic pumping membrane made by injection molding has been tested in real time while it was protected against overdistension by a polyurethane membrane. Its life duration has already exceeded 20,000,000 cycles without sign of undue stress.
Similarly, artificial ventricles made of the new HP-100 Silastic, plus Silastic valves, have been tested in mock circulation systems by the inventor. These tests have included both functional tests as to operation characteristics, as well as for blood compatibility measurement in a thrombus-provoking blood bag. Here again, the results have been positive at both levels of evaluation.
Where one adopts the more favorable Silicone materials over prior art polyurethane construction, it is important that the methods of fabrication carefully incorporate the differences required for use of Silicone materials. For example, Silicone is much more distensible and accordingly requires greater care. Silicone is also thermosetting, whereas the polyurethane is thermoplastic. Consequently, differences in fabrication, as well as subsequent treatment and application require special attention to the environment as well as handling techniques. Furthermore, it is difficult to develop techniques for vacuum forming Silicones, as compared to this method being the preferred fabrication procedure for polyurethanes. It is particularly important to note that the newer form of HP-100 Silicone elastomer requires different handling than the older Silicones which were used to make artificial hearts in the 1960's and early seventies. A final observation with respect to use of the new Silastic materials is that design limitations must be observed with respect to the strength of the material. Specifically, Silastic is durable but not very strong. The material in its fabricated form must therefore be protected by the use of safety membranes or safety chambers in the airline, or by screens to limit the extension of a pumping membrane in the diastole phase. It is believed that the discovery that Silicone polymers such as the new HP-100 available through Dow Corning represents a major step forward in artificial ventricle technology and one of an unexpected nature based on past inadequacies well known to those skilled in the art for Silicone materials.
In contrast to the soft and flexible structure of the blood sac 11, the inlet and outlet ports are generally best constructed of semi-rigid materials and may be interconnected by a bridging structure 23. The purpose of this more rigid bridging structure 23 is to maintain the respective inlet and outlet ports in relatively fixed positions during surgical implantation and subsequent use. These fixed positions conform to the proper location of the cuff 17 and graph 21 with respect to the attached soft tissue.
It will be apparent to those skilled in the art that the soft and flexible blood sac 11 disclosed in the figures and by description herein is intended to be exemplary of the general concept of a collapsible or foldable soft ventricle which can be substantially reduced in size during surgical implantation, thereby giving greater working space to the physician as appropriate suturing occurs with respect to the soft tissue points of attachment. It is to be understood, therefore, that this prior description is not to be considered limiting, but that other forms, configurations and compositions may be utilized to adopt this general concept as part of a total artificial system.
The second component of the subject invention comprises the semi-rigid shell 12 which is structurally separable from the blood pumping sac 11 and as shown in FIG. 1. In this embodiment, the shell is disclosed with two shell components 30 and 31. Although these illustrated components comprise approximately half-sections of the shell structure, it will be apparent to those skilled in the art that differing dimensions could likewise be applied wherein one shell component was of a lesser size than the second. The primary feature of the shell is to enable emplacement around the blood pumping sac 11 or subsequent removal therefrom. Therefore, the essential element of the shell is some form of opening means which permits such removal or emplacement.
In the illustrated embodiment, the shell includes two shell components 30 and 31 which are joined at a hinge section 33 or other form of closure means disposed at the remote edge from the forward open position closest to the blood sac in FIG. 1 The connecting hinge element 33 couples the joining peripheries 34 and 35 to form a clam-shell configuration. This analogy appropriately corresponds to the capability of clamshells to open or close by means of a connecting hinge or muscle joining one edge of the two shelled component structure. Similarly in the present case, the clam-shell configuration of this invention is capable of opening to permit insertion of the blood sac 11 and of closing around the blood sac to form a confining shell structure to limit expansion and displacement of the blood sac in response to operation of a pumping means. Accordingly, it is important for the shell and hinge or other form of enclosure means to totally enclose the sac up to the stiff ring 23 and inserted inlet and outlet ports 14 and 15. The interior surface of the shell is to be slightly larger in shape and size than the extended configuration of the wall structure of the blood pumping sac. Obviously, in this condition, the blood pumping sac is filled with blood and occupies substantially the full volume of the closed shell.
The shell illustrated in the figures includes an opening section or sections 35 and 36 which are designed to seal tightly around the respective inlet 14 and outlet 15 ports and at the interconnecting bridge 23. These mating components provide a circumferential seal at their respective junctures to prevent fluid exchange between the shell and the chest cavity.
A skirt member 38 may be provided to extend over the bridge 23 to facilitate a frictional seal, which may likewise be enhanced with adhesives. This skirt member 38 is attached at the bridge 23 and ports 14 and 15 or may simply include opening for emplacement around the blood sac ports much like a poncho. It is geometrically configured to conform to the exterior geometry of the semi-rigid construction of the ports and interconnecting bridge structure. During implantation, it is folded up or rolled up around the neck (FIG. 1) and will be deployed downwards over the entire artificial heart (FIG. 2) only after the implantation is completed and the heart is closed. One purpose is to offer an acceptable surface, such as DACRON Velour (trademark), to the surrounding tissues which will provide it with a thin, smooth layer of pseudoendothelium. It will be apparent that many forms of sealing mechanisms can be adopted in a similar manner to accomplish the objectives required for this invention.
Likewise, specific sealing structure can be applied around the peripheral edges of the clamshell structure to insure a complete sealed juncture at peripheries 35 of the respective shell halves. FIGS. 1 and 3 illustrate the use of tongue and groove construction wherein interior channel 40 provides a sealing seat for a raised flange 41 in opposing orientation on the contacting periphery of the shell. The sealed configuration of the shell at its tongue and groove peripheries 40 and 41 and at the skirt member 38 can be secured by means of a latch member 44, by adhesives or numerous other methods of securing the closed configuration of the shell. The illustrated latch is coupled near the shell opening and may operate with respect to latching means (not shown) at an opposing side of the skirt member 38 on the second shell component.
The shell structure also incorporates a pumping mechanism 50 which is coupled through the rigid shell 12 to enable alternating extension and collapse of a blood pumping sac 11 in a recurring pumping manner when the shell is in the closed configuration. Such pumping action is characteristic for artificial ventricles and provides the required inflow and expulsion of blood from the blood sac. Specifically, this pumping means 50 includes a fluid drive sac 51 which is integrally formed or adhesively attached at an interior surface 52 of the shell. This drive sac 51 is structured of flexible material and has sufficient volume during expansion with the shell in the closed configuration to develop the desired stroke volume for the ventricle. FIG. 4 illustrates a partially extended configuration of the drive sac in response to air flow 54 through a fluid drive line 55 which is utilized to deliver fluid to extend and contract the drive sac during pumping action. Specific construction and support pumping mechanisms are well known within the art and need no further explanation with respect to the present invention. Such drive systems may include either air, hydraulic fluid or other pressure sensitive flow systems, depending on the particular application of the ventricle employed.
Utilization of the present invention is illustrated by the following example. Initially, the blood pumping sac 11 is compressed, rolled up or otherwise flattened to minimize its structural size (see hyphenated lines 13 in FIG. 2) and is positioned within the chest cavity with atrial cuff 17 in proximate location for suturing to the atrium and graft 21 and its location for attachment to the pulmonary artery or aorta. The much reduced size of the ventricle permits the surgeon greater freedom of movement to perform the suturing and to visually inspect the attached ventricle upon implantation. At this stage, the blood pumping sac 11 is continuous with the atrium and the aorta on the left side and a comparable ventricle is continuous with the atrium and pulmonary artery on the right side. In the preferred embodiment, inlet and outlet valves 19 and 20 are already incorporated as part of these flexible blood pumping sacs.
After the suture lines with the natural atria, the natural aorta or the natural pulmonary artery have been completed, any residual air can be easily expelled with a cannula inserted via the natural atrium. By utilizing blood sacs which are clear, any residual air can be easily detected and voided from the ventricle. The blood sac is then allowed to fill with blood and the natural atrium and aorta are then clamped off. The suture lines can then be put under pressure by compressing the ventricles to confirm that the suture lines are tight and the heart is properly prepared for operation. These procedures are greatly facilitated by the absence of a heart shell or container as provided in the prior art. This represents a major step forward in ease and safety for this difficult and critical stage of artificial heart implantation. This stage of the procedure is represented by blood pumping sac 56 shown in FIG. 5.
The firm shell 57 is then placed over each ventricle. This shell is represented by two components 57a and 57b which are initially opened widely to permit insertion over the blood sac 56 in its sutured condition. The shell includes a pumping membrane 58 which defines the pumping chamber 59 coupled to a drive line 60. The shell members 57a and 57b are then closed and a mechanism is provided to insure proper alignment of the device on the left side between the atrium and the aorta, and on the right side between the atrium and the pulmonary artery. As previously mentioned, the interconnecting bridge shown in FIG. 3 provides part of this alignment positioning function. FIG. 6 illustrates the inserted position of the blood pumping sac 56 within the shell 57, with the pumping membrane 58 slightly displaced. Hinge means 61 is illustrated at the base of the respective shell members 57a and 57b to suggest the location of flexibility permitting opening and closing of the shell structure.
FIG. 7 illustrates the fully closed and sealed condition of the shell 57 about the blood pumping sac 56. The pumping membrane 58 is approaching its half full position in FIG. 7 and can be extended completely, almost reaching the other side 57 upon inflation of the pumping cavity or air sac 59. It will be apparent that a pusher plate or other mechanical device could be used in place of the air sac to develop the necessary physical displacement of the blood pumping sac 56 into its compressed condition. It will be apparent that the secure fastening of this ventricle is essential during the systole stage in view of the full pressure being asserted against the interior of the shell upon extension of the air sac 59.
FIGS. 8, 9 and 10 illustrate a further embodiment of the present invention wherein the shell of the left ventricle 70 and the shell of the right ventricle 71 can be combined to eliminate the dead space between the shells and the chest cavity. These shell components are joined at a common wall 72 which divide the shell into the respective left 73 and right 74 ventricle sections. The separating wall 72 can advantageously have an arcuate waveform cross-section (not shown in the figure) to allow a more physiologic location of the inflow and outflow ports 76 and 77 in FIG. 8. Separate drive lines 75 and 76 power the system to function as a normal heart. Inlet 76 and outlet 77 ports are constructed in accordance with the previous disclosure. FIG. 9 illustrates graph sections 78 which are attached to soft tissue at the pulmonary artery or aorta.
A stiff positioning ring 80 is formed as a single structure to maintain proper alignment of the respective openings and their attached graphs and atrial cuffs. This is in accordance with the description provided with respect to a single stiffening member identified in FIG. 3 as item 23. This stiffening member maintains the proper orientation of the respective one way valves with respect to the attached circulatory system openings.
The dual-ventricle device illustrated in FIGS. 8 and 9 is shown in an open configuration in FIG. 10. This construction enables attachment of both left and right ventricles as part of a single artificial heart, with subsequent emplacement of the dual-shell system with its respective drive line 75.
Other features of operation and construction will be apparent based on the foregoing description for the single ventricle. The total volume of this dual-shell heart is approximately 40 percent less because of the elimination of dead space between the ventricles. It also offers the advantage of less opportunity for growth of bacteria between the ventricles.
The general invention disclosed herein will greatly facilitate implantation of artificial hearts as a regular procedure in preserving the life of those patients waiting for heart transplants or for other patients for whom the artificial heart is a last resort. It will eliminate connectors between blood containing components and make the insertion of valves with or without valve rings possible. Because the ventricles can be rolled up, squeezed, bent and reduced in volume, they can be easily handled and surgically implanted. Any contained air can be easily removed and visually inspected by virtue of the transparent nature of the ventricle. Suture lines in the atrium, aorta and pulmonary arteries can readily be tested under pressure for leaks before putting the patient at risk.
It will be apparent to those skilled in the art that the embodiments disclosed herein are merely representative of the inventive concepts hereafter defined in the claims. Accordingly, no limitation is intended by way of disclosure except in accordance with proper construction of the following specific claims.
|Cited Patent||Filing date||Publication date||Applicant||Title|
|US4570903 *||Apr 19, 1982||Feb 18, 1986||Crass Otto G||Method and apparatus for measurement of valve stem thrust|
|US4573997 *||Mar 19, 1984||Mar 4, 1986||Research Corporation||Right ventricular assist device|
|US4578077 *||Nov 9, 1981||Mar 25, 1986||Nippon Zeon Co., Ltd.||Blood pump applicable to an artifical heart|
|Citing Patent||Filing date||Publication date||Applicant||Title|
|US5084064 *||Jun 15, 1989||Jan 28, 1992||Abiomed Cardiovascular, Inc.||Surgical cuff|
|US5211659 *||Nov 5, 1990||May 18, 1993||Strimling Walter E||Pump system suitable as a heart assist device|
|US5271746 *||Mar 18, 1992||Dec 21, 1993||Clinique De La Residence Du Parc||Implantable blood pump with inextensible deformable closed bag|
|US5282850 *||Jul 27, 1992||Feb 1, 1994||Smith & Nephew Richards, Inc.||Artificial heart components with wear resistant coatings of reduced thrombogenicity|
|US5370694 *||Jan 19, 1993||Dec 6, 1994||Smith & Nephew Richards, Inc.||Zirconium oxide and nitride coated endoprostheses for tissue protection|
|US5632623 *||Dec 28, 1994||May 27, 1997||University Of Utah Research Foundation||Mock circulation system|
|US5810708 *||Jun 6, 1995||Sep 22, 1998||Baxter International Inc.||Ventricular assist conduit with externally supported tissue valve|
|US6001056 *||Nov 13, 1998||Dec 14, 1999||Baxter International Inc.||Smooth ventricular assist device conduit|
|US6063115 *||Apr 11, 1997||May 16, 2000||Medtronic, Inc.||Cardiac assistance system|
|US6086527 *||Apr 2, 1998||Jul 11, 2000||Scimed Life Systems, Inc.||System for treating congestive heart failure|
|US6102845 *||Feb 7, 1994||Aug 15, 2000||Baxter International Inc.||Ventricular assist device with minimal blood contacting surfaces|
|US6110100 *||Apr 22, 1998||Aug 29, 2000||Scimed Life Systems, Inc.||System for stress relieving the heart muscle and for controlling heart function|
|US6280377||Jul 10, 2000||Aug 28, 2001||Scimed Life Systems, Inc.||System for treating congestive heart failure|
|US6540659||Nov 28, 2000||Apr 1, 2003||Abiomed, Inc.||Cardiac assistance systems having bi-directional pumping elements|
|US6547716 *||Nov 28, 2000||Apr 15, 2003||Abiomed, Inc.||Passive cardiac restraint systems having multiple layers of inflatable elements|
|US6572534||Sep 14, 2000||Jun 3, 2003||Abiomed, Inc.||System and method for implanting a cardiac wrap|
|US6602182||Nov 28, 2000||Aug 5, 2003||Abiomed, Inc.||Cardiac assistance systems having multiple fluid plenums|
|US6616596||Nov 28, 2000||Sep 9, 2003||Abiomed, Inc.||Cardiac assistance systems having multiple layers of inflatable elements|
|US6626821||May 22, 2001||Sep 30, 2003||Abiomed, Inc.||Flow-balanced cardiac wrap|
|US6669726||Feb 4, 2000||Dec 30, 2003||Juan M. Giambruno||Orthotopic total artificial heart|
|US6685627||Nov 19, 2001||Feb 3, 2004||Swaminathan Jayaraman||Modification of properties and geometry of heart tissue to influence heart function|
|US6749598||Jan 11, 1999||Jun 15, 2004||Flowmedica, Inc.||Apparatus and methods for treating congestive heart disease|
|US6846296||Sep 14, 2000||Jan 25, 2005||Abiomed, Inc.||Apparatus and method for detachably securing a device to a natural heart|
|US6994700||Mar 18, 2005||Feb 7, 2006||Flowmedica, Inc.||Apparatus and method for inserting an intra-aorta catheter through a delivery sheath|
|US7063679||Sep 20, 2002||Jun 20, 2006||Flowmedica, Inc.||Intra-aortic renal delivery catheter|
|US7066874||Jan 6, 2004||Jun 27, 2006||Bay Innovation Group, Llc||Devices and methods for blood flow assistance|
|US7104981||Oct 25, 2005||Sep 12, 2006||Flowmedica, Inc.||Apparatus and method for inserting an intra-aorta catheter through a delivery sheath|
|US7118525||Apr 22, 2004||Oct 10, 2006||Coleman Edward J||Implantable cardiac assist device|
|US7121291 *||Oct 14, 2003||Oct 17, 2006||Hiroshima University||Check valve, auxiliary circulating device and method for driving the auxiliary circulating device|
|US7122019||Nov 28, 2000||Oct 17, 2006||Flowmedica Inc.||Intra-aortic renal drug delivery catheter|
|US7217236 *||May 25, 2004||May 15, 2007||Innovamedica S.A. De C.V.||Universal pneumatic ventricular assist device|
|US7241273||Aug 6, 2003||Jul 10, 2007||Flowmedica, Inc.||Intra-aortic renal delivery catheter|
|US7329236||Sep 7, 2005||Feb 12, 2008||Flowmedica, Inc.||Intra-aortic renal drug delivery catheter|
|US7335192||May 13, 2003||Feb 26, 2008||Flowmedica, Inc.||Apparatus and methods for treating congestive heart disease|
|US7341570||Jul 3, 2003||Mar 11, 2008||Flowmedica, Inc.||Apparatus and methods for treating congestive heart disease|
|US7364566||Mar 18, 2005||Apr 29, 2008||Flowmedica, Inc.||Method and apparatus for intra-aortic substance delivery to a branch vessel|
|US7390293||Feb 2, 2004||Jun 24, 2008||Swaminathan Jayaraman||Modification of properties and geometry of heart tissue to influence function|
|US7481803||Apr 23, 2003||Jan 27, 2009||Flowmedica, Inc.||Intra-aortic renal drug delivery catheter|
|US7563247||Aug 6, 2003||Jul 21, 2009||Angiodynamics, Inc.||Intra-aortic renal delivery catheter|
|US7585836||May 13, 2005||Sep 8, 2009||Goodson Iv Harry Burt||Bi-lateral local renal delivery for treating congestive heart failure and for BNP therapy|
|US7691046||Jul 10, 2006||Apr 6, 2010||Pumpworks, Inc.||Nondestructive fluid transfer device|
|US7766961||Dec 5, 2005||Aug 3, 2010||Angio Dynamics, Inc.||Systems and methods for performing bi-lateral interventions or diagnosis in branched body lumens|
|US7771401||Jun 5, 2007||Aug 10, 2010||Angiodynamics, Inc.||Selective renal cannulation and infusion systems and methods|
|US7780628||May 1, 2000||Aug 24, 2010||Angiodynamics, Inc.||Apparatus and methods for treating congestive heart disease|
|US7811318||Apr 23, 2008||Oct 12, 2010||Syncardia Systems, Inc.||Apparatus and method for pneumatically driving an implantable medical device|
|US7914503||Mar 16, 2005||Mar 29, 2011||Angio Dynamics||Method and apparatus for selective material delivery via an intra-renal catheter|
|US7993325||Sep 29, 2005||Aug 9, 2011||Angio Dynamics, Inc.||Renal infusion systems and methods|
|US8012121||Jun 26, 2007||Sep 6, 2011||Angiodynamics, Inc.||Method and apparatus for selective material delivery via an intra-renal catheter|
|US8246530||Apr 5, 2010||Aug 21, 2012||Sullivan Paul J||Nondestructive fluid transfer device|
|US8376927||Mar 26, 2009||Feb 19, 2013||Vitalmex Internacional S.A. De S.V.||Fluid pumping ventricular assist device and components with static seal|
|US8430927 *||Feb 2, 2009||Apr 30, 2013||Medtronic, Inc.||Multiple orifice implantable heart valve and methods of implantation|
|US8518011||Aug 28, 2009||Aug 27, 2013||Angiodynamics, Inc.||Sheath for use in peripheral interventions|
|US8574310||Apr 15, 2011||Nov 5, 2013||Python Medical, Inc.||Stomach peristalsis device and method|
|US8585678||Mar 7, 2008||Nov 19, 2013||Angiodynamics, Inc.||Method and apparatus for intra-aortic substance delivery to a branch vessel|
|US8690959 *||Oct 10, 2011||Apr 8, 2014||Python Medical, Inc.||Implantable digestive tract organ|
|US8715156||Jun 23, 2008||May 6, 2014||Swaminathan Jayaraman||Modification of properties and geometry of heart tissue to influence function|
|US8771164||Jan 11, 2013||Jul 8, 2014||Vitalmex Internacional S.A. De C.V.||Fluid pumping ventricular assist device and components with static seal|
|US8869395||Apr 4, 2012||Oct 28, 2014||Vitalmex Internacional S.A. De C.V.||Fluid pumping device and components with static seal|
|US8954164 *||Jan 24, 2012||Feb 10, 2015||Arnold B. Vardiman||Electrical stimulator line protector|
|US9192461||Mar 24, 2014||Nov 24, 2015||Python Medical, Inc.||Implantable digestive tract organ|
|US20040059179 *||Aug 6, 2003||Mar 25, 2004||Mark Maguire||Intra-aortic renal delivery catheter|
|US20040059276 *||Sep 20, 2002||Mar 25, 2004||Flomedica, Inc.||Intra-aortic renal delivery catheter|
|US20040064089 *||Apr 23, 2003||Apr 1, 2004||Kesten Randy J.||Intra-aortic renal drug delivery catheter|
|US20040064091 *||May 13, 2003||Apr 1, 2004||Gad Keren||Apparatus and methods for treating congestive heart disease|
|US20040097900 *||Jul 3, 2003||May 20, 2004||Gad Keren||Apparatus and methods for treating congestive heart disease|
|US20040163714 *||Oct 14, 2003||Aug 26, 2004||Hiroshima University||Check valve, auxiliary circulating device and method for driving the auxiliary circulating device|
|US20040225177 *||Apr 22, 2004||Nov 11, 2004||Coleman Edward J.||Implantable cardiac assist device|
|US20040242954 *||May 25, 2004||Dec 2, 2004||Moises Calderon||Universal pneumatic ventricular assist device|
|US20050148810 *||Jan 6, 2004||Jul 7, 2005||Riebman Jerome B.||Devices and methods for blood flow assistance|
|US20050197624 *||Mar 4, 2005||Sep 8, 2005||Flowmedica, Inc.||Sheath for use in peripheral interventions|
|US20050245882 *||Mar 18, 2005||Nov 3, 2005||Flowmedica, Inc.||Method and apparatus for intra-aortic substance delivery to a branch vessel|
|US20050245892 *||Mar 18, 2005||Nov 3, 2005||Flowmedica, Inc.||Apparatus and method for inserting an intra-aorta catheter through a delivery sheath|
|US20050267010 *||May 13, 2005||Dec 1, 2005||Flowmedica, Inc.||Bi-lateral local renal delivery for treating congestive heart failure and for BNP therapy|
|US20060036218 *||Mar 16, 2005||Feb 16, 2006||Flowmedica, Inc.||Method and apparatus for selective material delivery via an intra-renal catheter|
|US20060052659 *||Sep 7, 2004||Mar 9, 2006||Topaz Stephen R||Cardiac device and method|
|US20060069323 *||Sep 22, 2005||Mar 30, 2006||Flowmedica, Inc.||Systems and methods for bi-lateral guidewire cannulation of branched body lumens|
|US20060149350 *||Dec 5, 2005||Jul 6, 2006||Flowmedica, Inc.||Systems and methods for performing bi-lateral interventions or diagnosis in branched body lumens|
|US20060167437 *||Dec 16, 2005||Jul 27, 2006||Flowmedica, Inc.||Method and apparatus for intra aortic substance delivery to a branch vessel|
|US20060189960 *||Sep 7, 2005||Aug 24, 2006||Flowmedica, Inc.||Intra-aortic renal drug delivery catheter|
|US20060252977 *||Jul 10, 2006||Nov 9, 2006||Sullivan Paul J||Nondestructive fluid transfer device|
|US20070100314 *||Nov 21, 2006||May 3, 2007||Flowmedica, Inc.||Apparatus and methods for treating congestive heart disease|
|US20070167670 *||Oct 9, 2006||Jul 19, 2007||Coleman Edward J||Implantable cardiac assist device with a phased electrode array|
|US20070167913 *||Oct 11, 2006||Jul 19, 2007||Flowmedica, Inc.||Vascular sheath with variable lumen construction|
|US20070213686 *||Feb 3, 2006||Sep 13, 2007||Flowmedica, Inc.||System and method for prevention of radiocontrast induced nephropathy|
|US20070249997 *||Jun 26, 2007||Oct 25, 2007||Flowmedica, Inc.||Method and apparatus for selective material delivery via an intra-renal catheter|
|US20070287967 *||Jun 5, 2007||Dec 13, 2007||Flowmedica, Inc.||Selective renal cannulation and infusion systems and methods|
|US20080221551 *||Mar 7, 2008||Sep 11, 2008||Flowmedica, Inc.||Acute kidney injury treatment systems and methods|
|US20080312492 *||Jun 23, 2008||Dec 18, 2008||Swaminathan Jayaraman||Modification of properties and geometry of heart tissue to influence function|
|US20090105799 *||Oct 22, 2008||Apr 23, 2009||Flowmedica, Inc.||Renal assessment systems and methods|
|US20090259292 *||Feb 2, 2009||Oct 15, 2009||Medtronic, Inc.||Multiple Orifice Implantable Heart Valve and Methods of Implantation|
|US20090264697 *||Mar 26, 2009||Oct 22, 2009||Innovamedica S.A.P.I. De C.V.||Fluid pumping device and components with static seal|
|US20090270981 *||Oct 29, 2009||Syncardia Systems, Inc.||Apparatus and method for pneumatically driving an implantable medical device|
|US20090318857 *||Dec 24, 2009||Flowmedica, Inc.||Sheath for use in peripheral interventions|
|US20100191036 *||Apr 5, 2010||Jul 29, 2010||Sullivan Paul J||Nondestructive fluid transfer device|
|US20120116536 *||Oct 10, 2011||May 10, 2012||Imran Mir A||Implantable digestive tract organ|
|CN102046220B||Mar 30, 2009||Sep 11, 2013||维塔尔梅克斯国际股份有限公司||Fluid pumping device and components with static seal|
|WO1991014464A1 *||Mar 26, 1991||Oct 3, 1991||Daniel Guilmet||Artificial heart|
|WO1995021638A1 *||Feb 9, 1995||Aug 17, 1995||Baxter Int||Blood pump system|
|WO2004105828A2||May 28, 2004||Dec 9, 2004||Innovamedica S A De C V||Universal pneumatic ventricular assist device|
|WO2009120056A1 *||Mar 30, 2009||Oct 1, 2009||Innovamédica S.A.P.I. De C.V.||Fluid pumping device and static sealing components|
|WO2011004400A1 *||Jul 8, 2010||Jan 13, 2011||Sujoy Kumar Guha||Replaceable artificial heart implantable by keyhole surgery|
|U.S. Classification||623/3.21, 600/16|
|International Classification||A61M1/10, A61M1/12|
|Cooperative Classification||A61M1/106, A61M1/12, A61M1/1037, A61M1/1098|
|Dec 19, 1988||AS||Assignment|
Owner name: UNIVERSITY OF UTAH RESEARCH FOUNDATION, THE, UTAH
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST.;ASSIGNOR:KOLFF, WILLEM J.;REEL/FRAME:005019/0477
Effective date: 19881130
|Aug 18, 1993||FPAY||Fee payment|
Year of fee payment: 4
|Aug 14, 1997||FPAY||Fee payment|
Year of fee payment: 8
|Sep 11, 2001||REMI||Maintenance fee reminder mailed|
|Feb 20, 2002||LAPS||Lapse for failure to pay maintenance fees|
|Apr 16, 2002||FP||Expired due to failure to pay maintenance fee|
Effective date: 20020220