|Publication number||US4911944 A|
|Application number||US 07/234,175|
|Publication date||Mar 27, 1990|
|Filing date||Aug 19, 1988|
|Priority date||Aug 19, 1987|
|Also published as||CA1263270A, CA1263270A1, DE3851996D1, DE3851996T2, EP0304819A2, EP0304819A3, EP0304819B1, US5290573|
|Publication number||07234175, 234175, US 4911944 A, US 4911944A, US-A-4911944, US4911944 A, US4911944A|
|Inventors||Bruce J. Holub|
|Original Assignee||Holub Bruce J|
|Export Citation||BiBTeX, EndNote, RefMan|
|Patent Citations (13), Non-Patent Citations (2), Referenced by (54), Classifications (11), Legal Events (4)|
|External Links: USPTO, USPTO Assignment, Espacenet|
The present invention relates to the field of animal husbandry, and in particular to the formulation of animal feeds and additives for animal feeds.
One of the prime objects in raising animals for meat production is to produce as healthful a product as possible, while maintaining commercially acceptable standards of, among other things, taste, texture and profitability.
It is known that increasing one's intake of omega-3 unsaturated fatty acids, in particular eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) may be very beneficial to one's health. In particular, these fatty acids have been shown to reduce hypertension and also to reduce serum lipids. For instance, Singer et al reported in "Long-term Effect of Mackerel Diet on Blood Pressure, Serum Lipids and Thromboxane Formation in Patients with Mild Hypertension" (Atherosclerosis, Vol. 62, p. 259-265 (1986) that a mackerel diet (mackerel being high in EPA) resulted in lowering of systolic and diastolic blood pressure, and lowering of serum triglyceride and cholesterol levels. Fish oil concentrate containing EPA has also been found to lower blood pressure and plasma triglycerides when given orally to human subjects by Mortensen et al. (Thrombosis and Haemestasis, Vol. 50, p. 543-546 (1983).
Moreover, the Applicant and Ahmed A. Ahmed reported in 1984 (Alteration and Recovery of Bleeding Times, Platelet Aggregation and Fatty Acid Composition of Individual Phospholipids in Platelets of Human Subjects Receiving a Supplement of Cod-Liver Oil" Lipids, Vol. 19, p. 617-624 (1984)) that ingestion of a fairly concentrated form of EPA, (Cod-liver oil) will result in significant alteration of the fatty acid composition of platelet phospholipids, with an increase in the amount of EPA present therein and a decrease in the amount of arachidonate present therein. This results in an increase in bleeding times, due to a lessening in platelet aggregation, and, more significantly, a strong suggestion that high-EPA platelets interact less with blood vessels walls than low EPA-high arachidonate do. This suggests that EPA may decrease the incidence of coronary thrombosis.
The sources of EPA are principally cold water marine fish, such as mackerel. These types of fish are staples in the diets of many peoples, such as the Greenland Eskimos and Coastal Norwegians. However, in other areas of the world, particularly North America, the consumption of fish is not nearly high enough for people to benefit from EPA or DHA (also found in cold water marine fish, and capable of producing similar effects) intake. That is, the principle sources of animal protein in North America are beef cattle, swine and chicken (poultry), and none of these sources yields meat which is high in omega-3 unsaturated fatty acids (EPA or DHA). In fact, each (but poultry to a minor extent only) tends to be high in saturated fats and cholesterol, thereby making them health risks.
There has been a trend of late for persons interested in maintaining good health to ingest fish oil (e.g., cod liver oil) or EPA supplements in capsule form. This is an expensive and potentially unhealthy way of making sure that sufficient omega-3 unsaturated fatty acid is in the diet. This approach results in the comsumption of extra fat calories without the nutritional benefits of ingesting protein, vitamins, and minerals as occurs when food rather than pharmaceutical sources of omega-3 are consumed. Furthermore, excessive and potentially unsafe levels of omega-3 fatty acids are unlikely to be consumed when taken in food sources.
The object of the present invention is to provide a novel feed supplement or additive for use in the production of feeds for beef cattle, swine and poultry, the use of which will result in a beef, pork or poultry meat (as the case may be) with enhanced omega-3 unsaturated fatty acid content.
Accordingly, in one broad aspect, the present invention relates to, as a feed additive for beef cattle, fish meal containing omega-3 unsaturated fatty acids.
The applicant has found, quite unexpectedly, that when beef cattle are fed a source of EPA, such as fish meal made from ocean fish, there is incomplete breakdown of the EPA in the digestive system of the animal, and a significant amount of that EPA is incorporated in the flesh of the animal, displacing naturally occuring fatty acids. There is no ill effect on the animal, and it is not necessary to feed massive quantities of fish meal supplement to the animal over prolonged periods of time. They tend to assimilate the EPA from the fish meal into their own flesh fairly rapidly so that it may be necessary to feed the supplement to beef cattle for as little as six weeks before slaughter to bring EPA levels in the beef flesh to a desirable level.
The following example will illustrate the present invention.
Three control cattle were fed a similar quantity of ration, but with no added fish meal.
The six animals were subsequently slaughtered and butchered and rib-eye steaks from each of them analyzed. The results were as follows:
TABLE A______________________________________ % of fatty acids % of fatty acidDiet in meat as EPA in meat as DHA______________________________________No fish meal 0.5 ± 0.3 0.2 ± 0.18% fish meal 1.6 ± 0.3 1.4 ± 0.4______________________________________
It will be observed, therefore, that the total enrichment of omega-3 unsaturated fatty acid was about four-fold (0.7 vs 3.0).
It is expected, moreover, that protein encapsulation of the omega-3 unsaturated fatty acid prior to feeding would further increase the concentration thereof in the end product. This would prevent degradation of omega-3 unsaturated fatty acid by the rumen. Moreover, because neither swine nor poultry have a rumen, even more favourable yields of omega-3 unsaturated fatty acids in the carcasses of fish meal fed pigs and chickens can be confidently expected.
|Cited Patent||Filing date||Publication date||Applicant||Title|
|US3159489 *||Dec 14, 1960||Dec 1, 1964||Swift & Co||Antemortem injection of flavoring in poultry|
|US3561976 *||Oct 31, 1966||Feb 9, 1971||Midwest Biochemical Corp||Method of tenderizing meat|
|US3669676 *||Jul 13, 1970||Jun 13, 1972||Ralston Purina Co||Feed intake limiting composition for cattle|
|US4738853 *||Apr 4, 1985||Apr 19, 1988||Efamol Ltd.||Food production|
|US4777162 *||Mar 25, 1986||Oct 11, 1988||Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo||Inclusion compound of eicosapentaenoic acid and food product containing the same|
|CA412389A *||May 11, 1943||Frith Ransford Mary||Food composition for animals and poultry|
|CA412486A *||May 11, 1943||Walter Whitmoyer Clarence||Feed or supplement for animals|
|GB263014A *||Title not available|
|GB280774A *||Title not available|
|GB484822A *||Title not available|
|GB651861A *||Title not available|
|GB1356002A *||Title not available|
|WO1988000439A1 *||Jul 21, 1987||Jan 28, 1988||Delatte Yves Gerard Andre||Method for producing fodder|
|1||Morrison, "Feeds and Feeding", Morrison Publishing Co., 1956, pp. 524-527.|
|2||*||Morrison, Feeds and Feeding , Morrison Publishing Co., 1956, pp. 524 527.|
|Citing Patent||Filing date||Publication date||Applicant||Title|
|US5032477 *||Dec 21, 1989||Jul 16, 1991||Zweckform Etikettiertechnik Gmbh||Multilayer adhesive label|
|US5290573 *||Feb 2, 1990||Mar 1, 1994||Holub Bruce J||Animal feed supplement|
|US5397591 *||Feb 4, 1991||Mar 14, 1995||Martek Biosciences Corporation||Infant formula and baby food containing docosahexaenoic acid obtained from dinoflagellates|
|US5407957 *||Feb 13, 1990||Apr 18, 1995||Martek Corporation||Production of docosahexaenoic acid by dinoflagellates|
|US5415879 *||Aug 29, 1994||May 16, 1995||Oh; Suk Y.||Method of reducing heart related disease in humans using eggs having relatively high percentage of long chain fatty acids|
|US5416115 *||Aug 9, 1993||May 16, 1995||University Of Maryland, Dept. Of Animal Sciences||Method for regulating milk fat and milk production using trans-fatty acids|
|US5492938 *||Feb 9, 1995||Feb 20, 1996||Martek Biosciences Corporation||Pharmaceutical composition and dietary supplement containing docosarexaenoic acid obtained from dinoflagellates|
|US5550156 *||Dec 19, 1994||Aug 27, 1996||Martek Corporation||Microbial oil mixtures and uses thereof|
|US5698244 *||Jun 7, 1995||Dec 16, 1997||Omegatech Inc.||Method for raising animals having high concentrations of omega-3 highly unsaturated fatty acids|
|US5711983 *||Jan 11, 1996||Jan 27, 1998||Martek Biosciences Corporation||Dinoflagellate biomass, methods for its production, and compositions containing the same|
|US5932257 *||Jun 20, 1997||Aug 3, 1999||University Of Guelph||Method for enriching docosahexaenoic acid in expressed milk of dairy cattle|
|US6403142||Dec 11, 1998||Jun 11, 2002||Ralston Purina Company||Hypoallergenic pet food|
|US6500471 *||Dec 4, 2000||Dec 31, 2002||Naohiko Sato||Method of raising edible animals|
|US6783792||Jun 4, 2002||Aug 31, 2004||Nestec S.A.||Method of making hypoallergenic pet food|
|US6821534||Jun 4, 2002||Nov 23, 2004||Nestec S.A.||Method of diagnosing and treatment of a pet with food allergies|
|US7001610||Oct 22, 2002||Feb 21, 2006||Omeganutrel Inc.||Food supplement and use thereof for elevating levels of essential fatty acids in livestock and products therefrom|
|US8124384||May 8, 2007||Feb 28, 2012||Martek Biosciences Corporation||Enhanced production of lipids containing polyenoic fatty acid by very high density cultures of eukaryotic microbes in fermentors|
|US8124385||May 8, 2007||Feb 28, 2012||Martek Biosciences Corporation||Enhanced production of lipids containing polyenoic fatty acid by very high density cultures of eukaryotic microbes in fermentors|
|US8129172||Dec 8, 2006||Mar 6, 2012||Martek Biosciences Corporation||Process for the heterotrophic production of microbial products with high concentrations of omega-3 highly unsaturated fatty acids|
|US8133706||May 8, 2007||Mar 13, 2012||Martek Biosciences Corporation||Enhanced production of lipids containing polyenoic fatty acid by very high density cultures of eukaryotic microbes in fermentors|
|US8187845||May 8, 2007||May 29, 2012||Martek Biosciences Corporation|
|US8187846||May 8, 2007||May 29, 2012||Martek Biosciences Corporation|
|US8206956||May 8, 2007||Jun 26, 2012||Martek Biosciences Corporation|
|US8216812||May 8, 2007||Jul 10, 2012||Martek Biosciences Corporation|
|US8288133||May 8, 2007||Oct 16, 2012||Dsm Ip Assets B.V.|
|US8288134||May 8, 2007||Oct 16, 2012||Dsm Ip Assets B.V.|
|US8288135||Oct 30, 2007||Oct 16, 2012||Dsm Ip Assets B.V.||Process for the heterotrophic production of microbial products with high concentrations of omega-3 highly unsaturated fatty acids|
|US8747916||Oct 30, 2012||Jun 10, 2014||Donald M. Smith||Selecting, producing, and feeding whole algae as a feed supplement for cattle and bison to produce meat high in omega 3's for human health|
|US8993009||Apr 21, 2014||Mar 31, 2015||Donald M. Smith||Selecting, producing, and feeding whole algae as a feed supplement for cattle and bison to produce meat high in omega 3's for human health|
|US20030035882 *||Jun 4, 2002||Feb 20, 2003||Nestle Purina Petcare Company||Method of making hypoallergenic pet food|
|US20030059517 *||Jun 4, 2002||Mar 27, 2003||Mcdaniel Lawrence||Method of diagnosing and treatment of a pet with food allergies|
|US20030198730 *||Oct 22, 2002||Oct 23, 2003||Stewart James F.||Food supplement and use thereof for elevating levels of essential fatty acids in livestock and products therefrom|
|US20050112233 *||Apr 5, 2004||May 26, 2005||Noble Raymond C.||Method for conditioning animals|
|US20060009522 *||Jun 30, 2005||Jan 12, 2006||Reza Dana||Compositions and methods for treating eye disorders and conditions|
|US20060094089 *||Aug 19, 2005||May 4, 2006||Martek Biosciences Corporation||Process for the heterotrophic production of microbial products with high concentrations of omega-3 highly unsaturated fatty acids|
|US20060188969 *||Apr 18, 2006||Aug 24, 2006||Martek Biosciences Corporation|
|US20070082384 *||Dec 8, 2006||Apr 12, 2007||Martek Biosciences Corporation||Process for the Heterotrophic Production of Microbial Products with High Concentrations of Omega-3 Highly Unsaturated Fatty Acids|
|US20070099280 *||Dec 7, 2006||May 3, 2007||Martek Biosciences Corporation||Process for the Heterotrophic Production of Microbial Products with High Concentrations of Omega-3 Highly Unsaturated Fatty Acids|
|US20070265341 *||Apr 17, 2007||Nov 15, 2007||The Schepens Eye Research Institute Inc.||Compositions and methods for treating eye disorders and conditions|
|US20080032362 *||May 8, 2007||Feb 7, 2008||Martek Biosciences Corporation||Enhanced Production of Lipids Containing Polyenoic Fatty Acid by Very High Density Cultures of Eukaryotic Microbes in Fermentors|
|US20080032363 *||May 8, 2007||Feb 7, 2008||Martek Biosciences Corporation||Enhanced Production of Lipids Containing Polyenoic Fatty Acid by Very High Density Cultures of Eukaryotic Microbes in Fermentors|
|US20080032364 *||May 8, 2007||Feb 7, 2008||Martek Biosciences Corporation||Enhanced Production of Lipids Containing Polyenoic Fatty Acid by Very High Density Cultures of Eukaryotic Microbes in Fermentors|
|US20080032365 *||May 8, 2007||Feb 7, 2008||Martek Biosciences Corporation|
|US20080032381 *||May 8, 2007||Feb 7, 2008||Martek Biosciences Corporation|
|US20080057551 *||May 8, 2007||Mar 6, 2008||Martek Biosciences Corporation|
|US20080153909 *||Oct 17, 2007||Jun 26, 2008||The Schepens Eye Research Institute, Inc.||Compositions and methods for treating eye disorders and conditions|
|US20080166780 *||Oct 29, 2007||Jul 10, 2008||Martek Biosciences Corporation||Process for the Heterotrophic Production of Microbial Products with High Concentrations of Omega-3 Highly Unsaturated Fatty Acids|
|US20080175953 *||Oct 19, 2007||Jul 24, 2008||Martek Biosciences Corporation|
|US20080199923 *||Oct 30, 2007||Aug 21, 2008||Martek Biosciences Corporation|
|US20080260859 *||Oct 11, 2005||Oct 23, 2008||Gudrun Claus-Herz||Composition Containing Omega-3 Fatty Acids and Omega-6 Fatty Acids|
|US20090047378 *||Feb 28, 2007||Feb 19, 2009||Adjuvants Plus Inc.||Non marine or non algal sourced omega 3 feed/food supplement and process for stabilizing, enhancing the conversion efficiency, and enrichment of omega 3 fatty acids in livestock/humans and products therefrom|
|US20100079899 *||Jul 29, 2009||Apr 1, 2010||Fujitsu Limited||Storage apparatus and method of adjusting the same|
|WO1991011918A1 *||Feb 4, 1991||Aug 22, 1991||Martek Corporation||Docosahexaenoic acid, methods for its production and compounds containing the same|
|WO2006007510A1 *||Jun 30, 2005||Jan 19, 2006||Schepens Eye Research||Compositions and methods for treating eye disorders and conditions|
|U.S. Classification||426/635, 426/807, 426/643, 426/646|
|International Classification||A23K1/16, A23K1/10|
|Cooperative Classification||A23K10/22, A23K20/158, Y10S426/807|
|European Classification||A23K1/16I, A23K1/10B|
|May 6, 1993||FPAY||Fee payment|
Year of fee payment: 4
|Feb 13, 1998||REMI||Maintenance fee reminder mailed|
|Mar 29, 1998||LAPS||Lapse for failure to pay maintenance fees|
|Jun 9, 1998||FP||Expired due to failure to pay maintenance fee|
Effective date: 19980401