|Publication number||US4944659 A|
|Application number||US 07/282,131|
|Publication date||Jul 31, 1990|
|Filing date||Jan 27, 1988|
|Priority date||Jan 27, 1987|
|Also published as||CA1303929C, EP0325618A1, WO1988005314A1|
|Publication number||07282131, 282131, PCT/1988/62, PCT/EP/1988/000062, PCT/EP/1988/00062, PCT/EP/88/000062, PCT/EP/88/00062, PCT/EP1988/000062, PCT/EP1988/00062, PCT/EP1988000062, PCT/EP198800062, PCT/EP88/000062, PCT/EP88/00062, PCT/EP88000062, PCT/EP8800062, US 4944659 A, US 4944659A, US-A-4944659, US4944659 A, US4944659A|
|Inventors||Robert E. L. Cox, Eduard H. J. Damhuis, Jean-Marie Labbe|
|Original Assignee||Kabivitrum Ab|
|Export Citation||BiBTeX, EndNote, RefMan|
|Patent Citations (8), Non-Patent Citations (2), Referenced by (127), Classifications (10), Legal Events (5) |
|External Links: USPTO, USPTO Assignment, Espacenet|
Implantable piezoelectric pump system
US 4944659 A
A dispensing device for use in an implantable drug delivery system for ambulatory patients comprises a pump in a drug reservoir and a piezoelectric disc element bonded to a diaphragm member forming one wall of a pump chamber and a battery and electrical circuits for cyclically applying electrical voltage to the piezoelectric member for inducing pumping movement in the diaphragm member to pump drugs from a reservoir via a valve and to a delivery catheter via another valve. A gas spring is provided to move the pump to maintain adequate pressure in the drug reservoir.
1. A dispensing device, comprising:
a housing forming a reservoir for fluid to be dispensed and a pump for dispensing the fluid located within the reservoir;
said pump including a pump chamber, a movable pump element and a piezoelectric element, said pump element being physically contiguous with and directly coupled to said piezoelectric element whereby changes in dimension of said piezoelectric element induce pumping movement in the movable pump element;
a source of electrical power connected to a control means for cyclically applying electrical voltage to said piezoelectric element for inducing periodic changes in dimension in said piezoelectric element;
a first one-way valve member bing directly connected between the fluid reservoir and the pump chamber for permitting flow of a fluid from said reservoir into said pump chamber upon movememt of the pump element and a second one-way valve member connected between the pump chamber and an outlet for dispensing said fluid from said pump chamber; and
means for maintaining the pressure of the fluid in the reservoir as the fluid is being dispensed, said pressure maintaining means including an expandable member having one end connected to said pump which closes a space defined by said expandable member.
2. A dispensing device according to claim 1, wherein said movable pump element comprises a flexible diaphragm forming a part of the wall of said pump chamber.
3. A dispensing device according to claim 1, wherein the source of electrical power is a battery in the shape of a disc and the control menas in the shape of a planar member, wherein the battery, control circuit and pump chamber are stacked upon one another to form a disc-like pump configuration.
4. A dispensing device according to claim 2, wherein the source of electrical power is a battery in the shape of a disc and the control means in the shape of a planar member, wherein the battery, control circuit and pump chamber are stacked upon one another to form a disc-like pump configuration.
5. A dispensing device according to claim 1, wherein said control means includes receiver means responsive to remotely transmitted electromagnetic waves for actuating said pump.
6. A dispensing device according to claim 2, wherein said control means includes receiver means responsive to remotely transmitted electromagnetic waves for actuating said pump.
7. A dispensing device according to claim 5, further comprising means for checking the condition of the source of electrical power.
8. A dispensing device according to claim 1, comprising an inlet chamber connected to said reservoir and sealed by an elastomeric member for permitting injection of the fluid into said reservoir by means of a hypodermic syringe.
9. A dispensing device according to claim 1, wherein said expandable member is a bellows.
BACKGROUND OF THE INVENTION
This invention relates to pumps of a small size particularly though not exclusively implantable pumps which are sufficiently small for use within the human body.
Pumps of small dimensions are used in implantable drug dispensing divices where a medicament is to be dispensed to an ambulatory patient on a regular or intermittent basis over an extended period of time, as where insulin is dispensed in the treatment of diabetes, or where chemotherapeutic drugs are dispersed in the treatment of cancer. In these circumstances it is advantageous in the treatment with the drug to perform an automatic dispensation of the drug without having to rely upon pills or injections. Thus a unit is implated within the patient comprising a reservoir of the drug and a pump, the pump being under control of a control circuit which may be coupled by an electromagnetic transmitter and receiver to an external control source.
Such a device for delivering the drug must be reliable in operation, sealed against body fluids and must hold a sufficient quantity of medication so as to avoid the need for frequent refills and must be refillable when empty. Furthermore, such dispensing systems must be physically small so as to be readily implatable without unnecessary disturbance of the body.
It is known to employ in such dispensing devices pumps such as the peristaltic type or solenoid type. Peristaltic pumps operate by responding to blood pressure within the body and solenoid pumps operate under control of an internal battery connected to a solenoid for operating a suitable pump mechanism. However such pumps are relatively large, and considering their size, are inefficient within the context of implantable units.
SUMMARY OF THE INVENTION
The present invention is based on the concept of a pump which incorporates a mechanism which is actuated by means or a piezoelectric element. Such a pump can be made of a very small size and is therefore suitable for use in an implatable drug delivery system. However, such a pump may be of use in whatever application where the requirement is for a pump of very small size.
The present invention therefore provides in general terms a pump comprising a source of electric power connected to means for cyclically applying electrical voltage to a piezoelectric element for inducing periodic changes in dimension in the piezoelectric element, the piezoelectric element, being physically contiguous with and directly coupled to a movable pump element whereby changes in dimension of the the piezoelectric element induce pumping movement into the movable pump member.
Thus, since all that is required to provide the pump motive power is a piezoelectric element and a source of electrical power, such as for example a battery, and since the piezoelectric element is contiguous with and directly coupled with the movable pump element with no intervening shaft or push rod, the piezoelectric pump may be made very small in dimensions.
The electrical power supplied to the piezoelectric element from the battery may be in pulsed d.c. form or alternatively and as preferred for efficiency it may be AC, with a suitable inverter circuit being provided.
The movable pump member may be of any suitable type, rotatable or displaceable, and the piezoelectric element may be coupled to the pump member in such a way as to induce the required type of movement. In a preferred embodiment, the movable pump member comprises a flexible membrane, movement of which increases or decreases the size of the pump chamber, which is coupled to a drug reservoir and an outlet port by suitable one way valves. Thus a decrease in volume of the pump chamber causes a drug within the pump chamber to be expelled through the valve of the outlet port, the valve at the inlet port remaining closed, whereas when the volume of the pump chamber is increased by movement of the membrane, the one way valve at the outlet port is closed whereas the one way valve at the inlet port is opened to permit further drug to be introduced into the pump chamber. As preferred, the piezoelectric element comprises a planar element extending over a substantial or major part of the surface area of the membrane and being firmly affixed to the surface thereof. Thus when dimensional changes are induced in a suitable direction in the piezoelectrical element, this causes the piezoelectric element to curve in one or two opposite directions from the plane in which it is disposed and the consequent bowing effect of the element causes a corresponding deformation of the membrane resulting in similar type of movement of the membrane. Thus the pump may be configured as essentially a flat disc-like element, with the piezoelectric element, the membrane forming the movable pump member and the pump chamber, all being of essentially planar form.
A preferred embodiment of the invention will now be described with reference to the accompanying drawings wherein:
DESCRIPTION OF THE DRAWINGS
FIG. 1 is a view in elevation of the exterior of an implantable dispenser incorporating a pump according to the invention:
FIG. 2 is a schematic cross-sectional view of the dispenser of FIG. 1;
FIG. 3a is a view in cross-section of the pump of the implantable dispenser with both valves down; and
FIGS. 3b is a view in cross-section of the pump of the implantable dispenser with both valves up; and
FIG. 4 is a block diagram of the electrical control circuit of the implantable dispenser.
BRIEF DESCRIPTION OF THE PREFERRED EMBODIMENTS
Referring now to the drawings, there is shown an implantable dispenser 2 for use in a drug delivery system where the dispenser is implanted into the body of a human being and is operative to dispense into the body suitable quantities of a drug at intervals under control of a circuit whithin the dispenser and as required under external control by means of a receiver/transmitter arrangement. The dispenser 2, as shown in FIG. 1, comprises an outer casing 3 of bio-compatible material, for example titanium alloy or stainless steel or biologically compatible silicone rubber. The dispenser body comprises a main portion 4 which is circular in elevation with a diameter of 3.5 cm (this dimension and the dimensions quoted below are approximate). The depth of the main portion 4 is 2.5 cm. A lobe portion 6 is provided having a width as measured from the circumference of the circular portion 4 of 1.5 cm and having a depth of 1.5 cm.
The overall configuration of the implantable dispenser is shown in FIGS. 2 and 3a and 3b as comprising a septum 8 mounted in lobe portion 6 and containing a radially compressed block of silicone rubber, an inlet 9 being provided for external access and a passageway 10 to a main drug reservoir region 12. In use, the reservoir 12 is filled by insertion of the hypodermic needle of a syringe into the silicone rubber insert via a passageway 9, so that the drug flows into the main reservoir region 12 via a passageway 10. Extraction of the needle, when the reservoir is filled, automatically closes the silicone block. Valves 14, 16 are provided with, inlet value 14 permitting entry of the drug into a pump 18 and outlet value 16 permitting exit of the drug from the pump body to a delivery catheter 20, which extends from the dispenser body to a suitable location within the human body. The pump is connected to an electronic control circuit by means of electrical leads 24, the electronic circuit being powered by a battery 26. A gas spring is provided in the area 30 between the pump and the electronic circuit 22 within the volume enclosed by a bellows 33. The function of the gas spring is to maintain an essentially constant pressure in reservoir 12 as the quantity of drug decreases during infusion. By selecting a suitable mixture of "Freon"-type hydrocarbons, which liquify at about one bar pressure, the pressure in the gas spring can be made to remain effectively constant (apart from the spring characteristics of the bellows) as the drug is used up and the bellows 33 opens.
The pump is shown in more detail in FIGS. 3a and 3b as being of generally flat and planar shape being 3.0 cm in diameter and 2 mm thick. The pump comprises two plate members 31, 32 of pressure molded titanium alloy and an intermediate plate 34 is also formed of titanium alloy. These plates define a port 36 for inlet valve 14 housing a freely movable valve member 38 and communicating with a passageway 40. Passageway 40 formed in intermediate plate 34 communicates with a pump chamber 42 and a further channel 44 formed in plate member 34 communicates with an outlet valve having a freely movable valve member 46 which is mounted in a recess 48 which communicates with outlet 50.
Titanium plate 32 defines a movable member to which is bonded a circular plane piezoelectric sheet 52. Suitable seals are provided (not shown) surrounding the valve members, the seals and valve members being made of biologically compatible materials, for example silicone rubber. The three plates 31, 32, 34 are sealed together by a technique such as electron beam welding or diffusion bonding. The piezoelectric element 52 is mounted on plate 32 using a conductive epoxy filled with silver.
In operation, when an electric voltage is applied across the thickness of the piezoelectric element 52, this creates a bowing, resulting in the central part of piezoelectric element moving out of the plane of the element a certain amount whereby a corresponding deformation in plate 32 and thus causing an expansion or contraction of volume of the pump chamber. Where expansion is caused, this creates a suction effect causing valve member 38 to be moved downwardly allowing drug from reservoir 12 to flow into the valve chamber. Outlet valve member 46 is maintained against passage 44 during this movement. Upon contraction of the space of the pump chamber caused by inward movement of plate 32, valve member 46 is pushed upward by permitting a drug to flow through the outlet valve 16.
Referring now to FIG. 4 there is shown the electronic circuitry for controlling the pump comprising an inductive loop antenna 60 which receives electrical signals from external control apparatus. This is connected to a receiver and transmitter 62, 64 which in turn provide and receive signals from a central control logic 66. A lithium battery 26 is coupled via a battery checking circuit 68 to control logic 66. Electronics circuits 70 are provided, coupled to sensors which are situated within the pump to monitor conditions, such as battery charge, critical operating voltages, internal humidity, pump/valve monitoring, quantity of drug in reservoir and rate of dispensation, clock settings and stored operating system. In addition sensors may be situated at parts of the human body to determine from biological conditions whether a drug should be administered. The control logic is also coupled to an oscillatory driver 72 which includes an inverter circuit and which provides alternating current to the pump for causing a pumping action of the pump. It may thus be seen that the pump can be controlled in any suitable manner to provide a regular or intermittent flow or drug to a person having this dispenser device implant-therewithin, the pump being controlled either internally by sensor devices mounted within the patient or externally by means of signals transmitted electromagnetically from an external control device.
The pump as described delivers very small quantities of fluid, as shown about 0.1 micro liters per pump sample. The advantages of the pump as described are its very small size and its cheapness as compared with peristaltic pumps or solenoid pumps and pump is therefore very suitable for applications where accurate quantities of liquid must be pumped in small amounts and where a pump of small size is required.
|Cited Patent||Filing date||Publication date||Applicant||Title|
|US4360019 *||Mar 31, 1980||Nov 23, 1982||Andros Incorporated||Implantable infusion device|
|US4487603 *||Nov 26, 1982||Dec 11, 1984||Cordis Corporation||Implantable microinfusion pump system|
|US4496343 *||Feb 6, 1984||Jan 29, 1985||Infusaid Corporation||Infusate pump|
|US4596575 *||May 23, 1984||Jun 24, 1986||Omikron Scientific Ltd.||Liquid delivery system particularly useful as an implantable micropump for delivering insulin or other drugs|
|US4604090 *||Nov 22, 1983||Aug 5, 1986||Consolidated Controls Corporation||Compact implantable medication infusion device|
|US4619653 *||Nov 4, 1982||Oct 28, 1986||The Johns Hopkins University||Apparatus for detecting at least one predetermined condition and providing an informational signal in response thereto in a medication infusion system|
|JPS59200083A *|| ||Title not available|
|JPS59203889A *|| ||Title not available|
|1||Spencer, W. J. et al., "An Electronically Controlled Piezoelectric Insulin Pump and Valves", May 1978, IEEE Transactions on Sonics and Ultiasonics, vol. SU-25, No. 3, pp. 153-156.|
|2|| *||Spencer, W. J. et al., An Electronically Controlled Piezoelectric Insulin Pump and Valves , May 1978, IEEE Transactions on Sonics and Ultiasonics, vol. SU 25, No. 3, pp. 153 156.|
|Citing Patent||Filing date||Publication date||Applicant||Title|
|US5378120 *||Feb 22, 1994||Jan 3, 1995||Alliedsignal Inc.||Ultrasonic hydraulic booster pump and braking system|
|US5391164 *||Mar 1, 1993||Feb 21, 1995||Giampapa; Vincent C.||Subcutaneous implantable multiple-agent delivery system|
|US5660846 *||Jun 2, 1995||Aug 26, 1997||Societe De Conseils De Recherches Et D'applications Scientifiques||Methods and apparatus for the delivery of solid drug compositions|
|US5669764 *||Oct 30, 1995||Sep 23, 1997||Bayer Corporation||Pneumatic diaphragm pump|
|US5837276 *||Sep 2, 1994||Nov 17, 1998||Delab||Apparatus for the delivery of elongate solid drug compositions|
|US5840062 *||Nov 8, 1995||Nov 24, 1998||Gumaste; Anand V.||Solid state fluid delivery system|
|US5902096 *||Feb 13, 1997||May 11, 1999||Bayer Corporation||Diaphragm pump having multiple rigid layers with inlet and outlet check valves|
|US6142972 *||Jul 7, 1998||Nov 7, 2000||Delab||Method and apparatus for the delivery of elongate solid drug compositions|
|US6206914||Aug 31, 1998||Mar 27, 2001||Medtronic, Inc.||Implantable system with drug-eluting cells for on-demand local drug delivery|
|US6306420||May 19, 2000||Oct 23, 2001||Societe De Conseils De Recherches Et D'applications Scientifiques, S.A.S.||Methods and apparatus for the delivery of solid drug compositions|
|US6334859 *||Jul 26, 1999||Jan 1, 2002||Zuli Holdings Ltd.||Subcutaneous apparatus and subcutaneous method for treating bodily tissues with electricity or medicaments|
|US6375649 *||Jan 7, 2000||Apr 23, 2002||Advanced Animal Technology Limited||Substance delivery device|
|US6409698||Nov 27, 2000||Jun 25, 2002||John N. Robinson||Perforate electrodiffusion pump|
|US6436069||Mar 25, 1996||Aug 20, 2002||Advanced Animal Technology Limited||Substance delivery device|
|US6497684||Apr 9, 2001||Dec 24, 2002||Schering Aktiengesellschaft||Syringe with a barrel having a sealing cap to hold a fluid medium within the barrel|
|US6500168||Jan 7, 2000||Dec 31, 2002||Advanced Animal Technology Ltd.||Substance delivery device|
|US6589229||Jul 31, 2000||Jul 8, 2003||Becton, Dickinson And Company||Wearable, self-contained drug infusion device|
|US6673596 *||Dec 2, 1999||Jan 6, 2004||Ut-Battelle, Llc||In vivo biosensor apparatus and method of use|
|US6723077||Sep 28, 2001||Apr 20, 2004||Hewlett-Packard Development Company, L.P.||Cutaneous administration system|
|US6740059||Aug 31, 2001||May 25, 2004||Insulet Corporation||Devices, systems and methods for patient infusion|
|US6749587||Feb 22, 2002||Jun 15, 2004||Insulet Corporation||Modular infusion device and method|
|US6768425||Dec 21, 2001||Jul 27, 2004||Insulet Corporation||Medical apparatus remote control and method|
|US6812217||Dec 4, 2000||Nov 2, 2004||Medtronic, Inc.||Medical device and methods of use|
|US6824561||Dec 20, 2000||Nov 30, 2004||Medtronic, Inc.||Implantable system with drug-eluting cells for on-demand local drug delivery|
|US6827559 *||Jul 1, 2002||Dec 7, 2004||Ventaira Pharmaceuticals, Inc.||Piezoelectric micropump with diaphragm and valves|
|US6830558 *||Mar 1, 2002||Dec 14, 2004||Insulet Corporation||Flow condition sensor assembly for patient infusion device|
|US6856073||Mar 13, 2003||Feb 15, 2005||The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration||Electro-active device using radial electric field piezo-diaphragm for control of fluid movement|
|US6869275 *||Feb 14, 2002||Mar 22, 2005||Philip Morris Usa Inc.||Piezoelectrically driven fluids pump and piezoelectric fluid valve|
|US6919669||Mar 12, 2003||Jul 19, 2005||The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration||Electro-active device using radial electric field piezo-diaphragm for sonic applications|
|US6960192||Apr 23, 2002||Nov 1, 2005||Insulet Corporation||Transcutaneous fluid delivery system|
|US6962579||Apr 22, 2002||Nov 8, 2005||Advanced Animal Technology Limited||Substance delivery device|
|US7001372||Feb 23, 2004||Feb 21, 2006||Zuli Holdings, Ltd.||Apparatus and method for treating body tissues with electricity or medicaments|
|US7018360||Jul 16, 2002||Mar 28, 2006||Insulet Corporation||Flow restriction system and method for patient infusion device|
|US7029455||Nov 15, 2002||Apr 18, 2006||Insulet Corporation||Devices, systems and methods for patient infusion|
|US7104767||Dec 29, 2004||Sep 12, 2006||Wilson Greatbatch Technologies, Inc.||Diaphragm pump for medical applications|
|US7128727||Sep 30, 2002||Oct 31, 2006||Flaherty J Christopher||Components and methods for patient infusion device|
|US7137964||Oct 28, 2003||Nov 21, 2006||Insulet Corporation||Devices, systems and methods for patient infusion|
|US7144384||Sep 30, 2002||Dec 5, 2006||Insulet Corporation||Dispenser components and methods for patient infusion device|
|US7195465 *||Oct 4, 2002||Mar 27, 2007||David Kane||Reciprocating microfluidic pump system for chemical or biological agents|
|US7291126||May 29, 2003||Nov 6, 2007||Nilimedix Ltd.||Drug delivery device and method|
|US7303549||Mar 21, 2005||Dec 4, 2007||Insulet Corporation||Transcutaneous fluid delivery system|
|US7311693||Apr 23, 2006||Dec 25, 2007||Nilimedix Ltd.||Drug delivery device and method|
|US7544190||Oct 14, 2003||Jun 9, 2009||Hewlett-Packard Development Company, L.P.||Cutaneous administration system|
|US7601148 *||Nov 6, 2002||Oct 13, 2009||Keller Hermann L||Infusion pump|
|US7682354||Apr 1, 2003||Mar 23, 2010||Aircom Manufacturing, Inc.||Dispenser having piezoelectric elements and method of operation|
|US7699834||Dec 13, 2005||Apr 20, 2010||Searete Llc||Method and system for control of osmotic pump device|
|US7733469||Apr 21, 2006||Jun 8, 2010||Arete' Associates||Image null-balance system with multisector-cell direction sensing|
|US7785319||May 31, 2005||Aug 31, 2010||Microtech Medical Technologies Ltd.||Method and apparatus for treating bodily tissues with medicinal substance|
|US7803148||Jun 7, 2007||Sep 28, 2010||Neurosystec Corporation||Flow-induced delivery from a drug mass|
|US7817030||Nov 9, 2005||Oct 19, 2010||Invention Science Fund 1, Llc||Remote controller for in situ reaction device|
|US7819858||Sep 13, 2006||Oct 26, 2010||The Invention Science Fund I, Llc||Remote controlled in vivo reaction method|
|US7850676 *||Apr 19, 2004||Dec 14, 2010||The Invention Science Fund I, Llc||System with a reservoir for perfusion management|
|US7857767||Dec 21, 2006||Dec 28, 2010||Invention Science Fund I, Llc||Lumen-traveling device|
|US7867217||Aug 9, 2007||Jan 11, 2011||The Invention Science Fund I, Llc||System with a reservoir for perfusion management|
|US7871402||Aug 9, 2007||Jan 18, 2011||The Invention Science Fund I, Llc||System with a reservoir for perfusion management|
|US7879023||Aug 9, 2007||Feb 1, 2011||The Invention Science Fund I, Llc||System for perfusion management|
|US7887505||Oct 8, 2003||Feb 15, 2011||Insulet Corporation||Flow condition sensor assembly for patient infusion device|
|US7896868||Aug 22, 2008||Mar 1, 2011||The Invention Science Fund I, Llc||Method and system for control of osmotic pump device|
|US7942867||Jan 18, 2006||May 17, 2011||The Invention Science Fund I, Llc||Remotely controlled substance delivery device|
|US7954457||Sep 14, 2005||Jun 7, 2011||Aircom Manufacturing, Inc.||Dispenser|
|US7998060||Jan 9, 2007||Aug 16, 2011||The Invention Science Fund I, Llc||Lumen-traveling delivery device|
|US8000784||Dec 21, 2006||Aug 16, 2011||The Invention Science Fund I, Llc||Lumen-traveling device|
|US8019413||Jan 12, 2009||Sep 13, 2011||The Invention Science Fund I, Llc||Lumen-traveling biological interface device and method of use|
|US8024036||Jan 12, 2009||Sep 20, 2011||The Invention Science Fund I, Llc||Lumen-traveling biological interface device and method of use|
|US8083710||Jul 8, 2008||Dec 27, 2011||The Invention Science Fund I, Llc||Acoustically controlled substance delivery device|
|US8092549||Sep 24, 2004||Jan 10, 2012||The Invention Science Fund I, Llc||Ciliated stent-like-system|
|US8108041||Feb 9, 2006||Jan 31, 2012||Zuli Holdings, Ltd.||Apparatus and method for treating body tissues with electricity or medicaments|
|US8109923||Aug 15, 2006||Feb 7, 2012||The Invention Science Fund I, Llc||Osmotic pump with remotely controlled osmotic pressure generation|
|US8114065||Oct 28, 2009||Feb 14, 2012||The Invention Science Fund I, Llc||Remote control of substance delivery system|
|US8141844||Oct 22, 2008||Mar 27, 2012||Codman NeuroSciences Sàrl||Flow rate accuracy of a fluidic delivery system|
|US8172833||Oct 28, 2009||May 8, 2012||The Invention Science Fund I, Llc||Remote control of substance delivery system|
|US8192390||Aug 22, 2008||Jun 5, 2012||The Invention Science Fund I, Llc||Method and system for control of osmotic pump device|
|US8202267||Oct 10, 2006||Jun 19, 2012||Medsolve Technologies, Inc.||Method and apparatus for infusing liquid to a body|
|US8236023||Mar 18, 2004||Aug 7, 2012||Allergan, Inc.||Apparatus and method for volume adjustment of intragastric balloons|
|US8240635||Oct 21, 2008||Aug 14, 2012||Codman Neuro Sciences Sárl||Flow rate accuracy of a fluidic delivery system|
|US8251888||Apr 5, 2006||Aug 28, 2012||Mitchell Steven Roslin||Artificial gastric valve|
|US8267905||May 1, 2006||Sep 18, 2012||Neurosystec Corporation||Apparatus and method for delivery of therapeutic and other types of agents|
|US8273071||Oct 1, 2009||Sep 25, 2012||The Invention Science Fund I, Llc||Remote controller for substance delivery system|
|US8273075||Dec 13, 2005||Sep 25, 2012||The Invention Science Fund I, Llc||Osmotic pump with remotely controlled osmotic flow rate|
|US8292800 *||Jun 9, 2009||Oct 23, 2012||Allergan, Inc.||Implantable pump system|
|US8298176||Jul 19, 2010||Oct 30, 2012||Neurosystec Corporation||Flow-induced delivery from a drug mass|
|US8308630||Aug 4, 2010||Nov 13, 2012||Allergan, Inc.||Hydraulic gastric band with collapsible reservoir|
|US8317677||Oct 6, 2009||Nov 27, 2012||Allergan, Inc.||Mechanical gastric band with cushions|
|US8323180||Jul 15, 2011||Dec 4, 2012||Allergan, Inc.||Hydraulic gastric band with collapsible reservoir|
|US8323263||Dec 9, 2010||Dec 4, 2012||The Invention Science Fund I, Llc||System with a reservoir for perfusion management|
|US8337482 *||Apr 19, 2004||Dec 25, 2012||The Invention Science Fund I, Llc||System for perfusion management|
|US8349261||Feb 12, 2009||Jan 8, 2013||The Invention Science Fund, I, LLC||Acoustically controlled reaction device|
|US8353872||Nov 9, 2011||Jan 15, 2013||Sims||Infusion pump|
|US8353896||May 4, 2006||Jan 15, 2013||The Invention Science Fund I, Llc||Controllable release nasal system|
|US8361013 *||Apr 19, 2004||Jan 29, 2013||The Invention Science Fund I, Llc||Telescoping perfusion management system|
|US8361014||Aug 9, 2007||Jan 29, 2013||The Invention Science Fund I, Llc||Telescoping perfusion management system|
|US8361056||Jan 18, 2011||Jan 29, 2013||The Invention Science Fund I, Llc||System with a reservoir for perfusion management|
|US8367003||Feb 12, 2009||Feb 5, 2013||The Invention Science Fund I, Llc||Acoustically controlled reaction device|
|US8372032 *||Aug 9, 2007||Feb 12, 2013||The Invention Science Fund I, Llc||Telescoping perfusion management system|
|US8377081||Sep 1, 2010||Feb 19, 2013||Allergan, Inc.||Closure system for tubular organs|
|US8382780||Aug 5, 2010||Feb 26, 2013||Allergan, Inc.||Fatigue-resistant gastric banding device|
|US8480622||Dec 17, 2010||Jul 9, 2013||Sims||Infusion pump|
|US8512219||Mar 19, 2007||Aug 20, 2013||The Invention Science Fund I, Llc||Bioelectromagnetic interface system|
|US8517915||Jun 10, 2010||Aug 27, 2013||Allergan, Inc.||Remotely adjustable gastric banding system|
|US8529551||Jun 9, 2006||Sep 10, 2013||The Invention Science Fund I, Llc||Acoustically controlled substance delivery device|
|US8568388||Jul 6, 2006||Oct 29, 2013||The Invention Science Fund I, Llc||Remote controlled in situ reaction device|
|US8585684||Nov 9, 2005||Nov 19, 2013||The Invention Science Fund I, Llc||Reaction device controlled by magnetic control signal|
|US8617141||Nov 9, 2005||Dec 31, 2013||The Invention Science Fund I, Llc||Remote controlled in situ reaction device|
|US8623042||Feb 18, 2010||Jan 7, 2014||Mitchell Roslin||Artificial gastric valve|
|US20070282261 *||Aug 9, 2007||Dec 6, 2007||Searete Llc||Telescoping perfusion management system|
|US20090270904 *||Apr 22, 2009||Oct 29, 2009||Birk Janel A||Remotely Adjustable Gastric Banding System|
|US20090306594 *||May 8, 2009||Dec 10, 2009||Changlin Pang||Drug-delivery pumps and methods of manufacture|
|US20090312785 *||Jun 9, 2009||Dec 17, 2009||Allergan, Inc.||Implantable Pump System|
|US20120041562 *||Oct 27, 2011||Feb 16, 2012||Pharmaco-Kinesis Corporation||Remotely Activated Piezoelectric Pump for Delivery of Biological Agents to the Intervertebral Disc and Spine|
|CN100467076C||Nov 6, 2002||Mar 11, 2009||L·凯勒 赫尔曼||Infusion pump|
|DE4405026A1 *||Feb 17, 1994||Aug 24, 1995||Rossendorf Forschzent||Mikro-Fluidmanipulator|
|DE10036102B4 *||Jul 25, 2000||Nov 29, 2007||Zuli Holdings Ltd.||Vorrichtung zum Behandeln von Körpergeweben mit Elektrizität oder Medikamenten|
|DE10066409B4 *||Jul 25, 2000||Dec 6, 2012||Zuli Holdings Ltd.||Vorrichtung zum Behandeln von Körpergeweben mit Elektrizität|
|EP0988838A2 *||Mar 25, 1996||Mar 29, 2000||Advanced Animal Technology Limited||Substance delivery device|
|EP0990425A2 *||Mar 25, 1996||Apr 5, 2000||Advanced Animal Technology Limited||Substance delivery device|
|EP2316505A2 *||Mar 14, 2007||May 4, 2011||University Of Southern California||Mems device for delivery of therapeutic agents|
|WO1993023096A1 *||Apr 29, 1993||Nov 25, 1993||Elan Med Tech||Liquid material dispenser|
|WO1994020076A1 *||Apr 9, 1993||Sep 15, 1994||Vincent C Giampapa||Subcutaneous implantable multiple agent delivery system|
|WO1997024528A2||Dec 31, 1996||Jul 10, 1997||Refael Bronstein||Multichannel microdosing apparatus|
|WO1998053777A1 *||May 28, 1997||Dec 3, 1998||Andrew L Abrams||Solid state fluid delivery system|
|WO2000036302A1||Dec 11, 1998||Jun 22, 2000||Us Gov As Represented By Thead||Ferroelectric pump|
|WO2001007110A2 *||Jul 23, 2000||Feb 1, 2001||Jacob Richter||Apparatus and method for treating body tissues with electricity or medicaments|
|WO2003039631A1||Nov 6, 2002||May 15, 2003||Hermann L Keller||Infusion pump|
|WO2003045302A2 *||Nov 26, 2002||Jun 5, 2003||Nili Med Ltd||Fluid drug delivery device|
|WO2003103763A1 *||May 27, 2003||Dec 18, 2003||Insulet Corp||Plunger assembly for patient infusion device|
|WO2004091690A2 *||Mar 26, 2004||Oct 28, 2004||Gary A Freeman||Probe insertion pain reduction method and device|
|WO2011049924A2 *||Oct 19, 2010||Apr 28, 2011||Pharmaco-Kinesis Corporation||A remotely activated piezoelectric pump for delivery of biological agents to the intervertebral disc and spine|
|Oct 11, 1994||FP||Expired due to failure to pay maintenance fee|
Effective date: 19940803
|Jul 31, 1994||LAPS||Lapse for failure to pay maintenance fees|
|Mar 8, 1994||REMI||Maintenance fee reminder mailed|
|Aug 10, 1992||AS||Assignment|
Owner name: KABI PHARMACIA AKTIEBOLAG, SWEDEN
Free format text: CHANGE OF NAME;ASSIGNOR:KABI VITRUM AKTIEBOLAG;REEL/FRAME:006223/0645
Effective date: 19920507
|Jan 19, 1989||AS||Assignment|
Owner name: KABIVITRUM AB, SWEDEN
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST.;ASSIGNORS:LABBE, JEAN-MARIE;DAMHUIS, EDUARD H. J.;COX, ROBERT E. L.;REEL/FRAME:005270/0956;SIGNING DATES FROM 19881103 TO 19881207