|Publication number||US5049142 A|
|Application number||US 07/227,528|
|Publication date||Sep 17, 1991|
|Filing date||Aug 2, 1988|
|Priority date||Nov 7, 1984|
|Publication number||07227528, 227528, US 5049142 A, US 5049142A, US-A-5049142, US5049142 A, US5049142A|
|Inventors||Robert S. Herrick, William F. Sardi|
|Original Assignee||Herrick Robert S, Sardi William F|
|Export Citation||BiBTeX, EndNote, RefMan|
|Patent Citations (1), Non-Patent Citations (13), Referenced by (79), Classifications (10), Legal Events (6)|
|External Links: USPTO, USPTO Assignment, Espacenet|
This is a continuation of application Ser. No. 06/929,895, filed Nov. 13, 1986, which is a Division of application Ser. No. 06/669,252 filed Nov. 7, 1984, and which issued as U.S. Pat. No. 4,660,546 on Apr. 28, 1987.
This invention relates to methods for treatment of the human eye having a deficiency of tears and an implant for the eye canaliculus.
This invention is an improvement over the laser punctal occlusion method disclosed and claimed in the Herrick U.S. Pat. No. 4,461,295, granted on July 24, 1984.
We have discovered that certain eye problems are related to the volume of tears on the surface of the eyes. Some of these problems include dry eyes, corneal ulcer, conjunctivitis, blepharitis, contact lens problems and many other external eye diseases. Punctal occlusion has also been proven to be an effective way of treating patients with conditions such as sinusitis, hay fever, middle eye infection (chronic), post nasal drip, front headache, etc. The Herrick U.S. Pat. No. 4,461,295 discloses a method for laser punctal occlusion. The punctal occlusion technique that is the subject of the Herrick patent is a technique that has been adopted by a number of physicians across the country and which Dr. Herrick has taught them. The laser punctal technique includes the use of a temporary suture to stitch the tear drainage canals of the eyes closed to determine if a greater tear volume on the surface of the eyes would improve certain eye problems. This diagnostic procedure has come to be known as a Herrick Stitch Test and has proven to be an effective surgical technique. The stitch test is performed by anesthetizing the local area around the lower or upper punctum of the eye. Puncta are the tear drainage canals located on the upper and lower eyelids near the nose. The stitch is carefully placed by an eye surgeon utilizing magnification of the eye. If after a preselected period the eye conditions improve, then, the doctor permanently closes the punctum by using an Argon laser. The laser occlusion operation also requires local anesthesia. The punctum may be reopened at a later time if excess tearing is experienced. This reopening of the puntum is also done by surgical and laser techniques, all as disclosed in my U.S. Pat. No. 4,461,295. It has now been found that the use of a temporary stitch test and a laser punctal occlusion has certain disadvantages in that it is uncomfortable for many patients who do not want their eyes tampered with and also because of the need of having the expensive laser equipment readily available in the doctor's office. It is an expensive procedure for the patient and takes time for the doctor and the patient.
It is presently known that devices have been placed in the lacrimal system to diagnose and treat various conditions. One such device is known as the punctum plug. This is described as a silicone, polyethylene or Teflon device which is placed in the punctum with a small portion extending outside the opening so it can be removed. This punctum plug is described in an article by Jerre M. Freeman, M.D. entitled "The Punctum Plug: Evaluation of a New Treatment for the Dry Eye" and appears in the publication of the transcripts of the American Academy of Ophthalomology and Optometry, pages OP-874 through OP-879. The punctum plug disclosed in the Freeman article is a device to completely close the punctum. The Freeman punctum plug is designed to completely close the punctum opening by having a slightly larger portion projecting into the vertical portion of the canaliculus that prevents the plug from extruding or coming out and a larger smooth head at the opening that prevents the plug from passing down into the canaliculus. The head is designed to be smooth and dome-shaped to permit it to rest in the lacrimal lake and against conjunctiva and cornea with little irritation. The Freeman punctum plug is subject to being wiped out by the plug wearer.
It is also known that a Pyrex glass tube was designed by Dr. Lester Jones for placement in the canaliculus to maintain a pathway from the eye to the nose. These Jones' tubes are 10 to 18 millimeters in length with upper flanges of 3-4 millimeters. A number of other silicone and polyethylene tubes have been designed and manufactured to recanalize a stenosed canaliculus. The literature is replete with disclosures that are designed to open up the passages in the eye canals, etc., but the Freeman punctum plug is the only known device for occluding the punctum.
The present invention provides an improved method of performing temporary and permanent horizontal canicular blockade without resorting to local anesthesia, the Herrick stitch test, or the need for the expensive laser equipment and that is of no discomfort to the patients. The method of canalicular blockade may be simply performed in less than five minutes by a general practitioner in his office without the need for special skills or expensive equipment. The invention also is directed to a novel design for the intercanalicular implant for blockade of the punctum that may be readily inserted within the horizontal portion of the canaliculus and is also readily removable.
From a broad method standpoint, the invention comprehends a method for treating external human eye conditions due to a deficiency of tears, including the steps of temporarily blockading the canaliculus of a patient without resorting to a temporary surgical stitch, observing the response of the patient's eye to the temporary blockade after a preselected period to note any improvement in the eye condition in response to the occlusion and, if an improvement in the eye condition is noted, placing an implant within the horizontal portion of at least one of the canaliculi of the patient. The step of temporarily blockading the canaliculus comprises the placing of an absorbable (by the body), removable, element, which may be in the form of catgut, in the canaliculus. The permanent implant that may be utilized is constructed and defined of a nonabsorbable (by the body) material having an end of reduced diameter to facilitate the implantation into and removal from the canaliculus. The implant per se may be further constructed and defined to facilitate the insertion and/or the removal of the implant.
The implant for the canaliculus of the human eye is constructed of a cylindrical solid element constructed of a material that is nonabsorbable by the human body and adapted to be insertable into the canaliculus, the element has a tapered smooth end which facilitates implantation and also removal from the canaliculus.
These and other features of the present invention may be more readily appreciated when considered in the light of the following specification and drawings, in which:
FIG. 1 is an illustration of the lacrimal system of the eye;
FIG. 2 is a schemmatic, enlarged view illustrating the configuration of the vertical and horizontal portion of a canaliculus from the punctum end with a removable implant formed of a collagen material, e.g. catgut, implant positioned in the horizontal portion of the canaliculus.
FIG. 2 is an illustration of an intercanalicular implant embodying the invention; and
FIGS. 4 through 11 are alternate designs of intercanalicular implants for the purposes of the present invention.
To facilitate the understanding of the present invention, a brief description of the human eye and the associated lacrimal system showing the paths of the tears from the sources of the tears to the nasal cavity will first be examined. The eye 10 illustrated in FIG. 1 includes the cornea and pupil as is well known. The source of the tears for the eye 10 are the crying tears which are produced by the large lacrimal gland 11, illustrated in the upper right hand portion of the drawing, and the constant tears are produced by a series of small glands 12 which are located below the large gland 11 and spaced apart above the cornea of the eye 10. The constant tears are the ones that are to be preserved in accordance with the present invention. Approximately 400 drops (9.5 milliliters) of tears are produced by the normal eye during the day and fewer tears are produced at night during sleep. Tears also protect the eye from infection since they contain an enzyme called lysozyme that acts as an antibiotic. With age, the eye produces less tears (about 60% less at age 65 than at age 18). The tears flow over the eyes and drain through small openings called puncta located in the lids of the eyes. The majority of the tears flow over the eyes and drain through the lower punctum and into the nasal passages. As illustrated in FIG. 1, the tears flow into the lower punctum 13 and upper punctum 14 which form openings into the corresponding lower canaliculus 15 and an upper canaliculus 16. In exiting the canaliculi 15 and 16, the tears merge in the lacrimal sac 17 from where they travel to the nasal lacrimal duct 18 and then drain to the nasal cavity (not shown). The canaliculi 15 and 16 are the drainage channels of the eyes and are about 10 millimeters long. The puncta 13 and 14 are the external openings of the surface of the eyelids that respectively lead to the canaliculi 15 and 16. The punctum is about 0.3 millimeters in diameter and is surrounded by a ring of connected tissue. From the punctal openings the canaliculi 15 and 16 run vertically for about 2 millimeters and then horizontally for about 8 millimeters. At the vertical canaliculi there is an ampula or sac which is 2 to 3 millimeters at its widest portion. This ampula narrows into the horizontal canaliculus which is only about 0.5 millimeters in diameter. The implant is to be placed in the horizontal portion of the canaliculus 15 or 16, as diagrammatically illustrated in FIG. 2, wherein the implant is identified as Imp.
The present invention generally follows the two step procedure disclosed in my prior U.S. Pat. No. 4,461,295, but eliminates the need for anesthesia, the laser equipment and the aforementioned problems associated therewith. To this end, a temporary blockade of the canaliculus of the patient is provided, without resorting to a temporary surgical stitch, to observe the response of the patient to the temporary blockade and, if improvements in the eye conditions of the patient are noted, a permanent blockade of the canaliculus is utilized by placing an implant within the horizontal portion of at least one of the canaliculi of the patient. To this end, the temporary blockade of the canaliculus is performed by inserting a piece of absorbable (by the body) material, such as catgut (shown in FIG. 2), in the canaliculus of the patient. It is well known to those skilled in the art that catgut is a suture material which consists primarily of collagen, a fibrous protein, and a description thereof is set forth in the 1982 PHYSICIANS DESK REFERENCE FOR OPHTHALMOLOGY, pages 19 through 21. The catgut may be a piece of 3-0 gauge catgut of approximately 5 millimeters in length. The doctor can place the catgut in the canaliculus of the patient under magnification without anesthesia through the use of a jeweler's forceps. The piece of catgut will swell in the canaliculus after placement therein. The catgut will remain in place for up to two weeks before it dissolves. Prior to dissolution, the catgut can be removed and, if desired, can be removed the same day it is implanted. This temporary occlusion of the canaliculus by means of the catgut replaces the need for the temporary stitch or the Herrick stitch test and the associated procedures that heretofore had been thought necessary. As in my previous patent, the patient is observed to determine if the eye condition improves as a result of the occlusion of the canaliculus preventing the drainage of the tears and, if so, a permanent implant Imp is placed in the canaliculus. It is preferred that the implant Imp be placed in the horizontal portion of the canaliculus, as illustrated in FIG. 2.
The implant Imp can be made to totally block the canaliculus or can be made with tiny passageways therethrough to permit varying amounts of tears to pass, depending upon the condition and needs of the patient as observed by the doctor. The total blockade is the usual case. The implant Imp may be constructed of materials that are nonabsorbable by the human body, such as a small piece of soft rubber or plastics, such as silicone, polyethylene, polypropelene, or Teflon having a length of approximately 5 millimeters. The implant Imp, however, may have lengths that fall within the range of 5 to 8 millimeters and diameters of 0.3 to 1.2 millimeters. The preferred diameter for the implant Imp is 0.5 millimeters. The basic configuration of the implant Imp is illustrated in FIG. 3 and is constructed and defined with one end of reduced diameter providing a smooth snub nose N and tapering from the nose N to the full diameter of 0.5 millimeters. As shown in FIGS. 3 through 10, the slope of the tapered end, referred to herein as the smooth continuously tapered end, or nose N defines a small acute angle, in the order of about 8°, relative to the cylindrical portion of the element defined by the implant Imp. The tapered end has a length which is between about one half of the axial length of the body portion and the axial length of the body portion. The narrow end of the implant Imp is placed in the punctum with forceps holding the blunter end, or the wider end, of the implant. The implant Imp is advanced through the punctum into the vertical portion of the canaliculus until it is advanced within the horizontal canaliculus, wherein it will reside. The permanent placement of the implant Imp is aided by the eye lid blink which propels fluid nasally into the canaliculus and by the negative pressure in the canaliculus. With this arrangement, the implant Imp is not easily rubbed out or washed out, as in the prior art device. The design of the implant Imp with a tapered end facilitates implantation and also removal thereof. The removal of the implant Imp is done by a doctor applying external pressure to the eye. For this purpose, the eye surgeon can utilize instruments to "massage" the canaliculus to advance it out of the punctum.
An advantage of the implant Imp relative to the laser blockade is that it may be readily and inexpensively removed to accommodate patients subject to seasonal changes and who experience dry eyes only in the summer months, so that the implant can be removed after the summer months. It can also be removed from patients who experience excess tearing (epiphora). A further advantage of the use of the implant Imp is that it prevents fast exit of medications placed on the surface of the eye, thereby rendering the medications more effective and longer lasting. The implant Imp would be contraindicated in patients who have a deformed canaliculus.
Now referring to FIG. 4 wherein an alternate design of the implant Imp for use in accordance with the present invention is illustrated. The implant of FIG. 4 has both ends defined with reduced diameters and a full diameter intermediate the ends to facilitate insertion and removal. The alternate designs illustrated in FIGS. 5 through 11 are also provided to further facilitate insertion and removal of the implants Imp. The embodiment illustrated in FIG. 5 is provided with a U-shaped handle H extending outwardly from the larger end of the implant Imp to be used for easier removal of the implant by grasping the handle H. Similarly, the implant Imp illustrated in FIG. 7 has attached thereto a thread TH that is secured to the implant at the larger end for easy removal. The thread TH may be constructed of nylon and have an adhesive patch AD secured to the free end thereof which may be applied along the nose of the patient for securing the thread TH thereto. The thread TH allows the implant Imp to be pulled through the punctum. Similarly, FIG. 8 illustrates an implant Imp that has a ring R constructed integrally with the implant and spaced outwardly a preselected distance from the end of the implant for ease of grasping of the implant for removal thereof.
FIG. 6, 9 and 10 illustrate implants Imp that include means for facilitating the insertion of the implant into the canaliculus. FIG. 6 illustrates an implant Imp having a hollow or axial tunnel T for facilitating insertion of the implant by the use of a stylet. FIG. 10 illustrates the same implant with a stylet arranged in the tunnel T. The stylet is identified by the letter S as a longitudinally extending thin probe with a cap C at the exposed end. FIG. 9 illustrates an implant Imp that has a concave notch CN at the large end of the implant, also, utilized for aiding the insertion of the implant.
FIG. 11 illustrates an implant Imp that may be consructed of two parts, with the second part M having a preselected configuration to be mounted to the nose N of the implant Imp and for loading it with medication to be delivered to the nasal passages, the stomach, or for any systemic medication. The illustrated configuration for the part M has one end defined to be complementary to the nose end of the part Imp to be carried thereby and a blunt nose for the opposite end. It should also be noted that the intercanalicular implant can also be used as a carrier or medium for distributing medications throughout the body. These medications can be loaded onto the intercanalicular implant Imp for timed release dosages to the eye. This release would work as a result of the reflex action of the eye and could be used, for example, to distribute antibiotics to the cornea, or glaucoma medications to the eye.
It should be noted at this point that to use a Schirmer tear strip paper placed inside the lower eyelid to determine if a patient has normal tear production is known. This Schrimer tear strip test was introduced by an Otto Schirmer in 1903 as a guide to, or confirmation of, the diagnosis of Keratitis Sicca. This test is now widely used and relied on by ophthalmologists. The base line secretions or the constant tears may be evaluated in theory by first applying a topical anesthetic to the eye to eliminate reflex lacrimation before insertion of the standard strip of filter paper. It has been found that the Schirmer tests may be misleading, although the Schirmer tests are routinely used with anesthtic and it has been found that it is only helpful when an abnormally low test result is obtained in the order of less than 3 millimeters of wetting. If as a result of the Schirmer test a dry eye is detected, then the temporary blockade of the canaliculus may be omitted and the permanent implant placed in the canaliculus immediately.
In testing for purposes of invention, the implant Imp, similar to that illustrated in FIG. 2, was constructed from a plain piece of clear silicone plastic and placed in a patient. The silicone plastic is not absorbable by the human body. However, as state hereinbefore, a temporary removable implant comprising a collagen material, e.g. catgut, is preferable for practicing this invention.
|Cited Patent||Filing date||Publication date||Applicant||Title|
|US4461295 *||Oct 21, 1983||Jul 24, 1984||Herrick Robert S||Laser punctal occlusion|
|1||C. V. Mosby Co. Publisher, 1980, p. 43 "Diagnosis and Treatment of Keratoconjunctivitis Sicca".|
|2||*||C. V. Mosby Co. Publisher, 1980, p. 43 Diagnosis and Treatment of Keratoconjunctivitis Sicca .|
|3||James T. Patten, M.D. "Punctal Occlusion with N-Butyl Cyanocrylate Tissue Adhesive", Opthalmic Surgery, Summer 1976, vol. 7, No. 1, pp. 24-26.|
|4||*||James T. Patten, M.D. Punctal Occlusion with N Butyl Cyanocrylate Tissue Adhesive , Opthalmic Surgery, Summer 1976, vol. 7, No. 1, pp. 24 26.|
|5||Jerre M. Freeman, M.D.; "The Punctum Plug: Evaluation of a New Treatment for the Dry Eye"; Transcripts of the American Academy of Opthalomology and Optometry; vol. 79, Nov.-Dec. 1975; pp. OP-874 through OP-879.|
|6||*||Jerre M. Freeman, M.D.; The Punctum Plug: Evaluation of a New Treatment for the Dry Eye ; Transcripts of the American Academy of Opthalomology and Optometry; vol. 79, Nov. Dec. 1975; pp. OP 874 through OP 879.|
|7||*||Jones LT.; Marquis MM, Vincent NJ: Lacrimal Function American Journal Ophthalmol 73: 658 659; 1972.|
|8||Jones LT.; Marquis MM, Vincent NJ: Lacrimal Function American Journal Ophthalmol 73: 658-659; 1972.|
|9||Louis A. Wilson, M.D., "External Diseases of the Eye", Harper & Row, 1979, p. 150.|
|10||*||Louis A. Wilson, M.D., External Diseases of the Eye , Harper & Row, 1979, p. 150.|
|11||*||Symposium on Medical and Surgical Diseases of the Cornea, Transactions of the New Orleans Academy of Opthalmology.|
|12||Wallace S. Foulds, "Intra-Canalicular Gelatin Implants in the Treatment of Kerato-Conjunctivitis Sicca", British Journal Ophthalmology (1961) 45, pp. 625-627.|
|13||*||Wallace S. Foulds, Intra Canalicular Gelatin Implants in the Treatment of Kerato Conjunctivitis Sicca , British Journal Ophthalmology (1961) 45, pp. 625 627.|
|Citing Patent||Filing date||Publication date||Applicant||Title|
|US5334137 *||Feb 21, 1992||Aug 2, 1994||Eagle Vision, Inc.||Lacrimal fluid control device|
|US5423777 *||Oct 27, 1993||Jun 13, 1995||Tajiri; Akira||Punctum plug|
|US5466233 *||Apr 25, 1994||Nov 14, 1995||Escalon Ophthalmics, Inc.||Tack for intraocular drug delivery and method for inserting and removing same|
|US5723005 *||Jun 7, 1995||Mar 3, 1998||Herrick Family Limited Partnership||Punctum plug having a collapsible flared section and method|
|US5766243 *||Jul 31, 1996||Jun 16, 1998||Oasis Medical, Inc.||Abrasive polished canalicular implant|
|US5826584 *||Oct 4, 1995||Oct 27, 1998||Schmitt; Edward E.||Devices for occluding channels in living mammals|
|US5830171 *||Aug 12, 1997||Nov 3, 1998||Odyssey Medical, Inc.||Punctal occluder|
|US5980928 *||Jul 29, 1997||Nov 9, 1999||Terry; Paul B.||Implant for preventing conjunctivitis in cattle|
|US6082362 *||May 5, 1999||Jul 4, 2000||Eagle Vision, Inc.||Punctum plug|
|US6149684 *||Oct 16, 1997||Nov 21, 2000||Herrick; Robert S.||Punctum plug having a thin elongated lip and a distal starting tip and method of using|
|US6234175||Jul 27, 1999||May 22, 2001||Medennium, Inc.||Smart ocular plug design and method of insertion for punctal and intracanalicular implants|
|US6299603||Aug 2, 1999||Oct 9, 2001||Karl I. Hecker||Injection apparatus and method of using same|
|US6309374||Aug 3, 1998||Oct 30, 2001||Insite Vision Incorporated||Injection apparatus and method of using same|
|US6378526||Aug 3, 1998||Apr 30, 2002||Insite Vision, Incorporated||Methods of ophthalmic administration|
|US6397849||Aug 2, 1999||Jun 4, 2002||Insite Vision Incorporated||Methods of ophthalmic administration|
|US6629533||Jun 30, 2000||Oct 7, 2003||Eagle Vision, Inc.||Punctum plug with at least one anchoring arm|
|US6994684||Jun 16, 2003||Feb 7, 2006||Alphamed Inc.||Punctum plugs having fluid collecting recesses and methods of punctal occlusion|
|US7017580||May 22, 2003||Mar 28, 2006||Clarity Corporation||Punctum plug system including a punctum plug and passive insertion tool therefor|
|US7204253||Oct 14, 2004||Apr 17, 2007||Clarity Corporation||Punctum plug|
|US7404825||Jun 5, 2002||Jul 29, 2008||Herrick Ii Robert S||Implant capable of forming a differential image in an eye|
|US7922702||Jul 1, 2005||Apr 12, 2011||Qlt Inc.||Treatment medium delivery device and methods for delivery of such treatment mediums to the eye using such a delivery device|
|US7998497||Apr 2, 2007||Aug 16, 2011||Qlt Inc.||Nasolacrimal drainage system implants for drug therapy|
|US8277830||Oct 4, 2011||Oct 2, 2012||Forsight Vision4, Inc.||Posterior segment drug delivery|
|US8298578||Oct 4, 2011||Oct 30, 2012||Forsight Vision4, Inc.||Posterior segment drug delivery|
|US8333726||Sep 8, 2008||Dec 18, 2012||Qlt Inc.||Lacrimal implants and related methods|
|US8399006||Jan 29, 2010||Mar 19, 2013||Forsight Vision4, Inc.||Posterior segment drug delivery|
|US8486052||Dec 27, 2010||Jul 16, 2013||The Johns Hopkins University School Of Medicine||Reservoir device for intraocular drug delivery|
|US8623395||Aug 5, 2011||Jan 7, 2014||Forsight Vision4, Inc.||Implantable therapeutic device|
|US8628792||Feb 7, 2012||Jan 14, 2014||Mati Therapeutics, Inc.||Drug cores for sustained release of therapeutic agents|
|US8691265||Oct 4, 2012||Apr 8, 2014||Mati Therapeutics, Inc.||Drug delivery methods, structures, and compositions for nasolacrimal system|
|US8702643||Aug 29, 2012||Apr 22, 2014||Mati Therapeutics, Inc.||Lacrimal implants and related methods|
|US8747884||Jul 18, 2011||Jun 10, 2014||Mati Therapeutics Inc.||Nasolacrimal drainage system implants for drug therapy|
|US8753666||Jan 30, 2008||Jun 17, 2014||Alcon Research, Ltd.||Punctal plugs and methods of delivering therapeutic agents|
|US8795711||Apr 2, 2007||Aug 5, 2014||Mati Therapeutics Inc.||Drug delivery methods, structures, and compositions for nasolacrimal system|
|US8795712||May 7, 2013||Aug 5, 2014||Forsight Vision4, Inc.||Posterior segment drug delivery|
|US8808727||Mar 15, 2013||Aug 19, 2014||Forsight Vision4, Inc.||Posterior segment drug delivery|
|US8905963||May 7, 2013||Dec 9, 2014||Forsight Vision4, Inc.||Injector apparatus and method for drug delivery|
|US9033911||Aug 5, 2011||May 19, 2015||Forsight Vision4, Inc.||Injector apparatus and method for drug delivery|
|US9066779||Jan 3, 2014||Jun 30, 2015||Forsight Vision4, Inc.||Implantable therapeutic device|
|US9132088||Apr 29, 2009||Sep 15, 2015||Mati Therapeutics Inc.||Composite lacrimal insert and related methods|
|US9168222||Apr 29, 2014||Oct 27, 2015||Mati Therapeutics Inc.||Nasolacrimal drainage system implants for drug therapy|
|US9180045||Apr 7, 2011||Nov 10, 2015||Mati Therapeutics Inc.||Treatment medium delivery device and methods for delivery of such treatment mediums to the eye using such a delivery device|
|US9180046||Jul 15, 2013||Nov 10, 2015||The Johns Hopkins University School Of Medicine||Reservoir device for intraocular drug delivery|
|US9216108||Feb 17, 2009||Dec 22, 2015||Mati Therapeutics Inc.||Lacrimal implants and related methods|
|US9417238||Nov 14, 2013||Aug 16, 2016||Forsight Vision4, Inc.||Posterior segment drug delivery|
|US9445944||Feb 28, 2014||Sep 20, 2016||Mati Therapeutics Inc.||Lacrimal implants and related methods|
|US9463114||Aug 29, 2014||Oct 11, 2016||Mati Therapeutics Inc.||Punctal plug with active agent|
|US9474756||Aug 6, 2015||Oct 25, 2016||Forsight Vision4, Inc.||Stable and soluble formulations of receptor tyrosine kinase inhibitors, and methods of preparation thereof|
|US9492315||Aug 5, 2011||Nov 15, 2016||Forsight Vision4, Inc.||Implantable therapeutic device|
|US9522082||Mar 3, 2016||Dec 20, 2016||The Johns Hopkins University||Reservoir device for intraocular drug delivery|
|US9526654||Mar 27, 2014||Dec 27, 2016||Forsight Vision4, Inc.||Ophthalmic implant for delivering therapeutic substances|
|US9610194||Feb 14, 2014||Apr 4, 2017||Mati Therapeutics Inc.||Drug delivery methods, structures, and compositions for nasolacrimal system|
|US9610271||Dec 20, 2013||Apr 4, 2017||Mati Therapeutics Inc.||Sustained release delivery of active agents to treat glaucoma and ocular hypertension|
|US20020198453 *||Jun 5, 2002||Dec 26, 2002||Herrick Family Limited Partnership||Implant capable of forming a differential image in an eye and methods of inserting and locating same|
|US20040231679 *||May 22, 2003||Nov 25, 2004||Prescott Anthony D.||Punctum plug system including a punctum plug and passive insertion tool therefor|
|US20040254516 *||Jun 16, 2003||Dec 16, 2004||Murray George W.||Punctum plugs having fluid collecting recesses and methods of punctal occlusion|
|US20050045188 *||Oct 14, 2004||Mar 3, 2005||Mendius Richard W.||Punctum plug|
|US20050095269 *||Nov 4, 2003||May 5, 2005||Ainpour Parviz R.||Gel plug for blockage of the canaliculus|
|US20050125022 *||Feb 28, 2003||Jun 9, 2005||Sundaram Ravikumar||Blood vessel occlusion device|
|US20050232972 *||Apr 15, 2004||Oct 20, 2005||Steven Odrich||Drug delivery via punctal plug|
|US20060074370 *||Sep 24, 2004||Apr 6, 2006||Medennium, Inc.||Ocular occluder and method of insertion|
|US20070243230 *||Apr 2, 2007||Oct 18, 2007||Forsight Labs, Llc||Nasolacrimal Drainage System Implants for Drug Therapy|
|US20070259021 *||May 1, 2007||Nov 8, 2007||Friedlaender Mitchell H||Compositions, Methods, and Kits for Treating Dry Eye|
|US20070299515 *||Nov 30, 2006||Dec 27, 2007||Herrick Robert S Ii||Implant capable of forming a differential image in an eye and methods of inserting and locating same|
|US20080181930 *||Jan 30, 2008||Jul 31, 2008||Alcon Research, Ltd.||Punctal Plugs and Methods of Delivering Therapeutic Agents|
|US20090098584 *||Aug 30, 2006||Apr 16, 2009||Bristol-Myers Squibb Company||Biomarkers and Methods for Determining Sensitivity to Vascular Endothelial growth factor Receptor-2 Modulators|
|US20090104243 *||Sep 5, 2008||Apr 23, 2009||Qlt Plug Delivery, Inc. - Qpdi||Drug cores for sustained release of therapeutic agents|
|US20090104248 *||Sep 8, 2008||Apr 23, 2009||Qlt Plug Delivery, Inc. -Qpdi||Lacrimal implants and related methods|
|US20090105749 *||Sep 5, 2008||Apr 23, 2009||Qlt Plug Delivery, Inc. - Qpdi||Insertion and extraction tools for lacrimal implants|
|US20090118702 *||Jul 1, 2005||May 7, 2009||Forsight Labs, Llc||Treatment Medium Delivery Device and Methods for Delivery of Such Treatment Mediums to the Eye Using such a Delivery Device|
|US20090240276 *||Jun 4, 2009||Sep 24, 2009||Parviz Robert Ainpour||Gel Plug For Blockage Of The Canaliculus|
|US20090264861 *||Feb 17, 2009||Oct 22, 2009||Qlt Plug Delivery, Inc.||Lacrimal implants and related methods|
|US20090280158 *||May 8, 2009||Nov 12, 2009||Qlt Plug Delivery, Inc.||Sustained release delivery of active agents to treat glaucoma and ocular hypertension|
|US20100040670 *||Oct 22, 2009||Feb 18, 2010||Qlt Plug Delivery, Inc.||Drug delivery via ocular implant|
|US20100049207 *||Aug 22, 2008||Feb 25, 2010||Turmes Jr Nicolas A||Jones tube inserter|
|US20100274204 *||Feb 23, 2010||Oct 28, 2010||Qlt Plug Delivery, Inc.||Lacrimal implants and related methods|
|WO1999044553A1||Mar 2, 1998||Sep 10, 1999||Herrick Family Limited Partnership||A punctum plug having a collapsible flared section and method|
|WO2007094577A1 *||Feb 5, 2007||Aug 23, 2007||Mal-Soo Jun||Bio artificial lacrimal canaliculus|
|WO2008094989A2||Jan 30, 2008||Aug 7, 2008||Alcon Research, Ltd.||Punctal plugs and methods of delivering therapeutic agents|
|U.S. Classification||604/294, 604/891.1, 604/892.1, 604/11|
|International Classification||A61F9/007, A61B17/12|
|Cooperative Classification||A61F9/00772, A61B17/12|
|European Classification||A61B17/12, A61F9/007T|
|Feb 4, 1994||AS||Assignment|
Owner name: LACRIMEDICS, INC., CALIFORNIA
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:HERRICK, ROBERT S.;REEL/FRAME:006858/0004
Effective date: 19940127
|Feb 16, 1995||FPAY||Fee payment|
Year of fee payment: 4
|Jul 9, 1996||AS||Assignment|
Owner name: HERRICK, ROBERT S., CALIFORNIA
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:LACRIMEDICS, INC. A CALIFORNIA CORPORATION;REEL/FRAME:008031/0967
Effective date: 19960529
|Aug 19, 1996||AS||Assignment|
Owner name: HERRICK FAMILY LIMITED PARTNERSHIP, A CA. LIMITED
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:HERRICK, ROBERT;REEL/FRAME:008085/0494
Effective date: 19960712
|Feb 25, 1999||FPAY||Fee payment|
Year of fee payment: 8
|Mar 14, 2003||FPAY||Fee payment|
Year of fee payment: 12