|Publication number||US5391139 A|
|Application number||US 08/201,484|
|Publication date||Feb 21, 1995|
|Filing date||Feb 23, 1994|
|Priority date||Sep 3, 1992|
|Publication number||08201484, 201484, US 5391139 A, US 5391139A, US-A-5391139, US5391139 A, US5391139A|
|Inventors||Gregory K. Edmundson|
|Original Assignee||William Beaumont Hospital|
|Export Citation||BiBTeX, EndNote, RefMan|
|Patent Citations (16), Referenced by (204), Classifications (6), Legal Events (3)|
|External Links: USPTO, USPTO Assignment, Espacenet|
This a continuation of U.S. patent application Ser. No. 07/940,077, filed Sep. 3, 1992, now abandoned.
The present invention relates to an apparatus and method for effecting radiation dosage planning to be used in rendering radiation treatment to a selected anatomical portion of an animal body, for example, the human prostate gland.
The prior art teaches treatment of localized malignancies with radiation emitted from a discrete radioactive source placed near the malignancy, such treatment commonly referred to as brachytherapy. Since the radioactive sources used in such treatment may constitute a hazard to the personnel administering same, apparatus is now commercially available which allows for the positioning of the radioactive source and the treatment therewith in the patient with minimum radiation exposure to the medical personnel rendering the treatment. Such apparatus allows the positioning and treatment with a radioactive source in the patient after the person administering the treatment moves away from the operating room in which the patient is being treated. Because the radioactive source is loaded into the patient after the medical personnel leave the area, such treatment delivery devices are generally referred to as after-loading devices.
The most recent commercially available radiation delivery devices in the after-loading category utilize a single high dose rate (HDR) source positioned at a plurality of preselected dwell positions within the anatomical part being treated for preselected dwell times. One such radiation delivery HDR after-loading device is commercially available from Nucletron Corporation of Columbia, Md. and is described in U.S. Pat. No. 5,084,001.
The positioning of the HDR source requires a radiation treatment plan which specifies the locations of the HDR source and the time period or dwell time at each such location at which the HDR source is to reside during treatment of the patient. Conventionally, medical personnel place a number of guide tubes or hollow needles for carrying the HDR source into the anatomical area to be treated, take X-rays of the needles in place and then manually digitize the X-ray data utilizing a mouse or courser for input to a dosage planning computer associated with the radiation delivery unit. A disadvantage of this conventional approach is the time required for such data digitization and entry. Data entry time has been found to be on the order of one hour. This delayed time period forces the delivery system to be in place with the patient for a prolonged time prior to actual administration of the treatment radiation dosages. Additionally, in the prior art, there is no provision for on-the-spot adjustments to the delivery system and/or its dosage plan using an interactive visual data system.
There is therefore seen to be a need for an apparatus and method for rapidly, reliably and interactively generating a radiation dosage plan based on real time data associated with a preselected placement of a radiation source delivery system with respect to the anatomical portion to be treated.
Accordingly, in one aspect of the invention, a real time radiation treatment dosage planning system for use in effecting radiation therapy of a preselected anatomical portion of an animal body includes a radiation delivery device for placing a radiation source at a plurality of positions within a volume of the anatomical portion, an imaging device for generating visual image data corresponding to the anatomical portion, and a processing unit, including a visual image data capturing element, operative to automatically generate in real time, in accordance with captured visual image data, a treatment plan including strength of the radiation source and time periods for which the radiation source is to be placed at each position by the radiation delivery unit.
In accordance with another aspect of the invention, a method for generating a radiation treatment dosage plan for use in applying radiation to a preselected anatomical portion of an animal body by a radiation delivery system operable to place a radiation source in a plurality of positions within a volume of the anatomical portion includes the steps of generating visual image data corresponding to the anatomical portion with a scanner, capturing the visual image data at a stored program processor and automatically generating, using the captured visual data, time periods during which the radiation source is to be placed at each of the positions, and transmitting an indication of the values of the radiation time periods to the radiation delivery system.
It is a feature of the invention that it enables localization techniques suitable for use in the operating room, very rapid reconstruction approaches to generating spatial coordinate data for the positions of the radiation source, rapid and reliable dose optimization, a fast and reproducible method of specifying a prescription dosage, and rapid calculation and display of the resulting dose distribution as an overlay to an image of the anatomical portion being treated. The calculation time for the dose distribution plan is greatly reduced by using scanner data itself for direct loading into a dosage calculation computer.
The objects and features of the invention will become apparent from a reading of a detailed description taken in conjunction with the drawings, in which:
FIG. 1 is a block diagram of an operating room and remote monitoring facility containing apparatus arranged in accordance with the principles of the invention;
FIG. 2 is a more detailed block diagram of real time radiation dosage planning system hardware arranged in accordance with the principles of the invention;
FIG. 3 is an overall flow chart of a method for real time dosage planning according to the principles of the invention and for use with radiation treatment of a human prostate gland;
FIG. 4 is a flow chart setting forth further details of the video data based reconstruction of radiation source coordinate data step of FIG. 3;
FIG. 5 is a flow chart setting forth further details of the radiation source dwell time optimization step of FIG. 3; and
FIG. 6 is a flow chart setting forth further details of the normalization step of FIG. 3.
With reference to FIG. 1, an overall floor plan layout 100 of an operating room with remote monitoring facilities for use in radiation oncology is depicted. The patient is placed on an operating table 101 having an overhead TV monitor 103 for use by a radiation oncologist 109. The oncologist and a radiation technician or other medical personnel at 107 utilize a real time planning system unit 105 in conjunction with HDR radiation delivery unit 113 for effecting subsequent radiation treatment after the medical personnel have left the operating room.
An anesthetist is positioned at location 117 and utilizes conventional anesthesia equipment located at anesthesia cart 115. Monitoring of the anesthesia equipment from a remote location is effected via data link 123 which runs to a remote anesthesia monitoring station at 139 which includes a remote control 137 and a TV monitor 135 which is coupled to a TV camera 119 in the operating room via bus 125. A remote treatment control center has an HDR delivery control unit 133 and a TV monitor 131 which are coupled to HDR unit 113 and a second TV camera 121 via buses 129 and 127, respectively.
Optionally, the real time dosage planning hardware 105 may be directly coupled to a control unit of HDR delivery unit 113 for direct down loading of dose planning data.
HDR delivery unit 113 comprises, for example, apparatus as disclosed in the abovereferenced U.S. Pat. No. 5,084,001, which is hereby incorporated by reference. As set forth in U.S. Pat. No. 5,084,001, HDR source 113 includes a moving or indexing apparatus such as a stepper motor for moving a radiation source assembly along a plurality of guide tubes extending therefrom and having remote ends which are implantable in a preselected anatomical portion of a patient, typically using access through at least one orifice in the patient's body and positioned such that the end portion is near the site of intended therapy. A control unit of apparatus 113 is capable of causing the source assembly to (a) be moved from a standby position to the end portion of each guide tube and positioned at each of a series of preselected discrete steps lying within the end portion of each guide tube, (b) allowing the source assembly to remain at each of the preselected positions for a preselected residence or dwell time, and (c) causing the source assembly to be withdrawn from the end portion of each guide tube to a rest position.
Further details of the apparatus of real time planning system 105 of FIG. 1 are set forth in the block diagram of FIG. 2. In this specific exemplary embodiment, the prostate gland of a human patient is to be treated. With reference to FIG. 2, video data for use by the apparatus and method of the invention is generated by means of an ultrasound scanner 201 and associated ultrasound probe 205, the scanner including a video display unit 203 which displays the prostate gland 229, a section of the rectal cavity 231, both being overlaid by a grid 227 whose use will be discussed at a later section of this description.
Video data generated by scanner 201 is coupled via bus 233 to a "frame grabber" or video adapter board 209 of computer 207. Computer 207 is additionally coupled via bus 237 to a monitor 211 which displays patient and radiation delivery guide tube information, along with a reconstructed image of the anatomy to be treated at window 225. The patient and physician data is in section 221 of the display, while the coordinate positioning of the radiation delivery needles or guide tubes is set forth at portion 223 of the display. Additionally, a dosage profile resulting from the automatically generated dosage plan is displayed at window 225 in overlay fashion with respect to the image of the anatomical part being treated.
Computer 207 may additionally be coupled via a bus 239 to a standard printer 215 for generating hard copy 217 of the generated dosage plan. Computer 207 may also be coupled via bus 235 to a video printer 213 operable to produce a hard copy of the visual data presented at monitor 211. An example of such hard copy is shown at 219.
Ultrasound scanner 201 could, for example, comprise a Kretz Combison 310a scanner and transrectal transducer probe and bifocal multiplane rectal transducer IRW177 AK/A, available from Kretz Technik AG of Austria. A suitable computer has been found to be the Dell 486P/66 i 486 DX2, a 66 MHz system available from Dell Computer Corporation of Austin, Tex. The frame grabber 209 is a desk top video adapter and could comprise, for example, a commercially available unit available from Cardinal Technologies, Inc. of Lancaster, Pa.
An exemplary embodiment of a general overall dosage planning procedure is set forth in the flow chart of FIG. 3. With reference to FIG. 3 (and the apparatus depicted in FIGS. 1 and 2) the procedure is initiated at step 301 by entry of patient data into computer 207. At step 303 the radiation source data is referenced. This data has been previously entered at computer 207.
Image data from ultrasound scanner 201 of FIG. 2 is then continuously captured at step 305 by frame grabber unit 209 of computer 207 (FIG. 2). At this point, the medical personnel in operating room 100 determine, using the displayed video data, a top and bottom reference level for the anatomical portion, such as the prostate gland, to be treated, and then draw contours of the anatomical portion at step 309 on the reference image displayed at monitor 211 using conventional data entry apparatus such as a mouse unit.
Next, at step 311, the medical personnel choose a candidate radiation source guide tube or needle location using predetermined placement rules which have been empirically determined from experience. The guide tube or needle is then inserted via a template pad by HDR unit 113. Alternatively the dosage planning system can proceed with its calculations and interactive display of a dosage profile without actual implantation of the needles, thereby enabling the medical personnel to judge the acceptability of theoretical results prior to such implantation. At step 315 the medical personnel visually confirm that the needle location is acceptable by viewing a visual representation of a transverse section of the needle and surrounding anatomical tissue generated by the ultrasound scanner unit.
At step 317 the position of the needle is captured at computer 207 utilizing a courser or mouse in conjunction with the video display at monitor 211. Next, at steps 319 through 325, a tentative real time dosage plan comprising a specification of dwell time periods at each dwell position of the radiation source within all presently implanted guide tubes or needles is generated by computer 207.
This automatic generation includes step 319 for reconstructing a model of the three dimensional structure of the dwell positions in the needles implanted so far, an optimization step 321 for determining relative dwell times of the source at each dwell position, and a normalization step 323 in which relative dwell times may be converted to actual dwell times. The dosage profile resulting from the plan thus far is then displayed at monitor 211 at step 325 of FIG. 3. If the final plan has been determined, then a hard copy of this display may be generated by video printer 213.
At decision block 327 the displayed dosage profile which is superimposed at window 225 of monitor 211 over the anatomical portion, such as the prostate gland, to be treated, is viewed by the medical personnel, and if an acceptable dose profile covers an acceptable portion of the anatomical volume, then the procedure advances to step 329. Otherwise, a new needle location is chosen at step 311 and the steps 313 through 325 are re-executed. The planning system of this invention inherently accommodates movement of the anatomical portion being treated, in that the real time output of the scanner is continuously captured and displayed. The movement is typically caused by the implantation process itself and can be taken into account by subsequent needle placement during the process of FIG. 3. It is therefore seen that the planning system of this invention inherently assures improved maintenance of proper registration of the implant with respect to the treated anatomical portion. When a sufficient number of needles or guide tubes have been implanted and an acceptable plan generated for all of the needles, the dosage level is checked by the medical personnel at step 329, and if found unacceptable, the normalization of the dwell times is changed at step 331 until the dose is found to be satisfactory.
Next, at step 333, the position of the anatomical portion such as the prostate is rechecked via ultrasound scanner 201 of FIG. 2, and if it has been found to have been moved by the implantation of the guide tubes or needles, then the needles are advanced at step 337 into their proper relative positions with respect to the anatomical portion to be treated. If the position of the anatomical portion is acceptable, then the final dosage treatment plan is printed and/or downloaded directly to delivery element 113 of FIG. 1, and actual radiation treatment of the anatomical portion can begin.
The video based reconstruction step 319 of FIG. 3 is set forth in further detail of the flow chart of FIG. 4. Basically, this routine generates a model of the three dimensional structure of the dwell positions in the plurality of guide tubes or needles that have been implanted. Input data to the routine of FIG. 4 includes the number of guide tubes or needles, the active length of each, the depth or location along the y axis of a reference scanning plane, the length of each indexable step of a radiation source in each guide tube and, for each needle, an identification or ordinal number, its coordinate in the x,z plane at a positioning template and, the x,z coordinates of the needle at the reference scan plane.
Video reconstruction or modeling from a transverse ultrasound scan is illustrated. A series of guide tubes or needles are placed using the template with known spacing between guide holes (e.g. a rectangular array 5 millimeters on center). An ultrasound scanner using an intracavitary probe is used to image the needles transverse to their length. By moving the probe in or out using a carriage, the depth of the ends of the guide tubes or needles may be determined. This is used to establish an origin of the y axis. The length of a tumor volume is likewise determined, thus determining the range of y values (i.e. the "active length") to be treated along each needle. The transverse plane or x,z positions of the needles are known at the level of the template, due to its known geometry. Another set of x and z coordinates are measured from a transverse scan at a known depth (y). From the two points x,y,z (template) and x,y,z (reference scan), a vector is constructed for each needle which allows the x and z components to be interpolated from the template and reference values for any value along the y axis. The radiation source dwell positions can then be determined by stepping off the proper distance along each guide tube or needle and recording the resulting x,y,z coordinate and current needle number at each step. The final output of the routine is a count of the dwell positions and a data structure which lists, for each dwell position, its identification or ordinal number (i.e. a number within the implant as a whole), the identification of the needle that the dwell position resides in and the spatial cartesian coordinates of the dwell position.
With reference to FIG. 4, the reconstruction basic steps comprise reading the input data at step 401, selecting a next needle at step 403 and a next dwell position within that needle at step 405. Then at step 407, utilizing the template and reference positional data, the x,y,z cartesian coordinate values for the dwell position of interest are interpolated at step 407, and an initial weight and dwell time in relative unitless values are assigned. This interpolation process is repeated for every dwell position in the implant using the tests at steps 409 and 411, and when all dwell positions have been modeled, the data is output at step 413.
The geometric optimization of relative radiation source dwell times at each dwell position in the implant is performed at step 321 of FIG. 3, and the details of the optimization method are set forth in the flow chart of FIG. 5. Geometric optimization is method for providing either a uniform or other distributed radiation dose throughout the anatomical portion implanted with the guide tubes.
With reference to FIG. 5, the dwell data generated in the previous reconstruction step 319 of FIG. 3 is read and, for each dwell position, a relative dwell position radiation dose is generated by calculating the contribution to the radiation dose level at the dwell position of interest from all other radiation source locations in other guide tubes in the implant. This calculation is performed at step 503 and is based upon the known principle that a relative dose level is proportional to the inverse square of the distance between the dwell position of interest and other dwell positions in the implant.
At step 505 of FIG. 5 a relative dwell time for each dwell position is set equal to the reciprocal of the corresponding relative dwell position dose calculated at step 503. Next, at step 507, a maximum value of the relative dwell time generated at step 505 is determined, and at step 509 all the relative dwell times are then normalized by dividing each by the determined maximum value. The output dwell times are then passed on to the further normalization step of FIG. 3 at step 511 of FIG. 5.
Further details of the normalization step 323 of FIG. 3 are set forth in the flow chart of FIG. 6. Normalization is a method for determining a normalization factor for a tissue volume treated with radiation sources positioned in accordance with the geometric optimization step 321 of FIG. 3. Such a normalization factor is necessary, because the optimization step only determines relative dwell times, not actual times to be used for treatment. The normalization factor is arbitrary. However, the factor may be adjusted later by the medical personnel in order to "fine tune" the delivered dosage. (E.g.--see steps 329 and 331 of FIG. 3).
Normalization to the minimum dose in the treated anatomical volume provides a highly automated method of dose prescription, consistent with a goal of producing a complete treatment plan immediately after the placement of each individual implant guide tube or needle. This allows the medical personnel to base needle placement decisions on the actual dose distributions presented at a display in real time (and overlaying an image of the anatomy to be treated) rather than relying solely upon arbitrary placement rules, which may not produce ideal dosage distributions or accurate registration with the intended anatomical volume.
The normalization routine generates dose calculation points midway between pairs of randomly selected dwell positions. This is an efficient search mechanism for finding local dose minima in volume implants for anatomical portions having external surfaces with no concave cavities--i.e. having a convex configuration. The normalization method assumes that the number of dwell positions, a prescribed dose level, current source strength and dwell times are available as input. Each dwell position is known by its identification number and coordinate data generated in the reconstruction step 319 of FIG. 3.
With reference to FIG. 6, the dwell data is read at step 601 and a reference dose is set to a large arbitrary value that is selected in accordance with empirically determined guide lines. At step 605 two dwell positions within the implant model are chosen at random and a dose is calculated at a point midway between the selected dwell positions at step 607. Again, this conventional calculation is generally based on the principle that the dose level at a given point is proportional to the inverse of the square of the distance from the source. Next, the method determines the minimum of the calculated doses at steps 609 and 615 wherein, if a calculated dose is less the reference dose value, then the reference dose value becomes that calculated dose and the reference point is then selected to have the coordinates of the present dose calculation point under consideration. The adjustments of the reference dose and reference coordinates are effected at steps 611 and 613. When the minimum dose has been determined, then its corresponding reference coordinates and the minimum dosage are output at step 617. The normalization factor is then calculated as the prescribed dose divided by the minimum dose determined by the routine.
The position of the reference point is displayed to the user, as it is possible for the reference point to lie outside the volume of the anatomical portion, if such volume has concave surface portions. In such a case the normalization will require a relatively large adjustment. If the normalization point is within the volume of the anatomical portion to be treated, an adjustment larger than plus or minus 10 percent constitutes a quality assurance "caution" flag. Actual dwell times for the radiation source are then derived from the relative dwell times by multiplying each relative dwell time determined in step 321 of FIG. 3 by the normalization factor generated by the routine of FIG. 6.
After medical personnel verify, from observing an overlaid dosage profile superimposed on an image of the pertinent anatomy, that the implant geometry is acceptable, a typical plan output in hard copy form may be generated and typically comprises specification of a prescribed dose, a reference point within the implant which receives the minimum or reference dose and a normalization factor with which the user may determine actual dwell times by multiplying the relative dwell times listed by the normalization factor.
Using the principles of the invention to rapidly generate a dosage treatment plan, a prototype system has been used for prostate gland treatment, and the initiation of the actual radiation treatment has been effected within 10 to 15 minutes of final needle placement. The dosage plan generation time has been reduced from on the order of one hour, using conventional prior art techniques, to approximately 1 second for a typical implant of 15 guide tubes or needles of approximately four centimeters active length.
The invention has been described with reference to a detailed description of a preferred embodiment. These details have been set forth for the sake of example and the scope of the invention is to be determined solely by proper interpretation of the appended claims.
It is to be noted that this invention is additionally contemplated for use as a determinant of implant source positioning with other types of implant therapy, such as temporary continuous brachytherapy (using on the order of days of implantation time) or permanent implant therapy.
|Cited Patent||Filing date||Publication date||Applicant||Title|
|US3847138 *||Mar 14, 1973||Nov 12, 1974||Gollub S||Method and system for controlled automated administration of drugs to patients|
|US4244357 *||Jan 5, 1979||Jan 13, 1981||Morrison Richard A||Method and apparatus for homogeneously irradiating the vaginal mucosa with a linear source uterovaginal applicator|
|US4245646 *||Jun 19, 1978||Jan 20, 1981||Picker Corporation||Nuclear cardiology apparatus and method|
|US4280494 *||Jun 26, 1979||Jul 28, 1981||Cosgrove Robert J Jun||System for automatic feedback-controlled administration of drugs|
|US4292960 *||Apr 30, 1979||Oct 6, 1981||Rca Corporation||Apparatus and method for application of radioactive and microwave energy to the body|
|US4397314 *||Aug 3, 1981||Aug 9, 1983||Clini-Therm Corporation||Method and apparatus for controlling and optimizing the heating pattern for a hyperthermia system|
|US4562829 *||May 1, 1984||Jan 7, 1986||E. R. Squibb & Sons, Inc.||Strontium-rubidium infusion system|
|US4624846 *||Jul 24, 1984||Nov 25, 1986||Immunomedics, Inc.||Method for enhancing target specificity of antibody localization and clearance of non-target diagnostic and therapeutic principles|
|US4798209 *||Jan 9, 1987||Jan 17, 1989||Siemens Aktiengesellschaft||Method and apparatus for non-contacting identification of the temperature distribution in an examination subject|
|US4815448 *||Apr 7, 1986||Mar 28, 1989||Mills Randell L||Mossbauer cancer therapy|
|US4976680 *||Oct 7, 1988||Dec 11, 1990||Hayman Michael H||Apparatus for in situ radiotherapy|
|US5080101 *||Jun 19, 1989||Jan 14, 1992||Edap International, S.A.||Method for examining and aiming treatment with untrasound|
|US5084001 *||Aug 9, 1990||Jan 28, 1992||Eric van't Hooft||Method and apparatus for effecting radioactive therapy in an animal body|
|US5107839 *||May 4, 1990||Apr 28, 1992||Pavel V. Houdek||Computer controlled stereotaxic radiotherapy system and method|
|US5205289 *||Jun 8, 1990||Apr 27, 1993||Medical Instrumentation And Diagnostics Corporation||Three-dimensional computer graphics simulation and computerized numerical optimization for dose delivery and treatment planning|
|SU1392696A1 *||Title not available|
|Citing Patent||Filing date||Publication date||Applicant||Title|
|US5690107 *||Apr 24, 1996||Nov 25, 1997||Lap Gmbh Laser Applikationen||Method for positioning and marking a patient at a diagnostic apparatus|
|US6019718 *||May 30, 1997||Feb 1, 2000||Scimed Life Systems, Inc.||Apparatus for intravascular radioactive treatment|
|US6027446 *||Nov 6, 1998||Feb 22, 2000||Washington Univ. Of Office Of Technology Transfer||Pubic arch detection and interference assessment in transrectal ultrasound guided prostate cancer therapy|
|US6032066 *||Jan 15, 1998||Feb 29, 2000||Jcrt Radiation Oncology Support Services||Method and apparatus for virtual radiotherapy beam projection localization in real space|
|US6059713 *||Mar 5, 1998||May 9, 2000||Scimed Life Systems, Inc.||Catheter system having tubular radiation source with movable guide wire|
|US6059812 *||Mar 6, 1998||May 9, 2000||Schneider (Usa) Inc.||Self-expanding medical device for centering radioactive treatment sources in body vessels|
|US6071227 *||Jan 27, 1997||Jun 6, 2000||Schneider (Europe) A.G.||Medical appliances for the treatment of blood vessels by means of ionizing radiation|
|US6074338 *||Jun 28, 1994||Jun 13, 2000||Schneider (Europe) A.G.||Medical appliances for the treatment of blood vessels by means of ionizing radiation|
|US6083167 *||Feb 10, 1998||Jul 4, 2000||Emory University||Systems and methods for providing radiation therapy and catheter guides|
|US6099454 *||Mar 6, 1997||Aug 8, 2000||Scimed Life Systems, Inc.||Perfusion balloon and radioactive wire delivery system|
|US6110097 *||Mar 6, 1997||Aug 29, 2000||Scimed Life Systems, Inc.||Perfusion balloon catheter with radioactive source|
|US6117065 *||Jun 24, 1998||Sep 12, 2000||Scimed Life Systems, Inc.||Perfusion balloon catheter with radioactive source|
|US6146322 *||Oct 30, 1996||Nov 14, 2000||Schneider (Europe) Ag||Irradiating filament and method of making same|
|US6167294 *||Feb 3, 1997||Dec 26, 2000||Busch; Martin||Method and apparatus for producing benefit/risk evaluation data relating to radiation therapy in patients|
|US6200255 *||Oct 30, 1998||Mar 13, 2001||University Of Rochester||Prostate implant planning engine for radiotherapy|
|US6203485||Oct 7, 1999||Mar 20, 2001||Scimed Life Systems, Inc.||Low attenuation guide wire for intravascular radiation delivery|
|US6231494||Nov 17, 1997||May 15, 2001||Schneider (Europe) A.G.||Medical device with radiation source|
|US6234951||Jan 10, 1997||May 22, 2001||Scimed Life Systems, Inc.||Intravascular radiation delivery system|
|US6251060 *||Aug 17, 1999||Jun 26, 2001||Nucletron B.V.||Apparatus and method for temporarily inserting a radioactive source in an animal body|
|US6256529 *||Nov 24, 1997||Jul 3, 2001||Burdette Medical Systems, Inc.||Virtual reality 3D visualization for surgical procedures|
|US6258019||Sep 8, 1999||Jul 10, 2001||Scimed Life Systems, Inc.||Catheter for intraluminal treatment of a vessel segment with ionizing radiation|
|US6264596||Nov 3, 1997||Jul 24, 2001||Meadox Medicals, Inc.||In-situ radioactive medical device|
|US6267775||Mar 6, 2000||Jul 31, 2001||Schneider (Usa) Inc.||Self-expanding medical device for centering radioactive treatment sources in body vessels|
|US6273858||Jun 26, 2000||Aug 14, 2001||Emory University||Systems and methods for providing radiation therapy and catheter guides|
|US6302865||Mar 13, 2000||Oct 16, 2001||Scimed Life Systems, Inc.||Intravascular guidewire with perfusion lumen|
|US6325758 *||Oct 27, 1998||Dec 4, 2001||Nomos Corporation||Method and apparatus for target position verification|
|US6327490||Feb 26, 1999||Dec 4, 2001||Varian Medical Systems, Inc.||Brachytherapy system for prostate cancer treatment with computer implemented systems and processes to facilitate pre-implantation planning and post-implantation evaluations with storage of multiple plan variations for a single patient|
|US6352501||Sep 23, 1999||Mar 5, 2002||Scimed Life Systems, Inc.||Adjustable radiation source|
|US6360116||Feb 26, 1999||Mar 19, 2002||Varian Medical Systems, Inc.||Brachytherapy system for prostate cancer treatment with computer implemented systems and processes to facilitate pre-operative planning and post-operative evaluations|
|US6398708||Oct 28, 1998||Jun 4, 2002||Scimed Life Systems, Inc.||Perfusion balloon and radioactive wire delivery system|
|US6398709||Oct 19, 1999||Jun 4, 2002||Scimed Life Systems, Inc.||Elongated member for intravascular delivery of radiation|
|US6413203||Sep 16, 1998||Jul 2, 2002||Scimed Life Systems, Inc.||Method and apparatus for positioning radioactive fluids within a body lumen|
|US6416457||Mar 9, 2000||Jul 9, 2002||Scimed Life Systems, Inc.||System and method for intravascular ionizing tandem radiation therapy|
|US6422989||Nov 5, 1999||Jul 23, 2002||Scimed Life Systems, Inc.||Method for intravascular radioactive treatment|
|US6438401||Aug 11, 2000||Aug 20, 2002||Alpha Intervention Technology, Inc.||Indentification and quantification of needle displacement departures from treatment plan|
|US6512942 *||May 18, 2000||Jan 28, 2003||Computerized Medical Systems, Inc.||Radiation therapy and real time imaging of a patient treatment region|
|US6514191||Jan 25, 2000||Feb 4, 2003||Schneider (Europe) A.G.||Medical appliances for the treatment of blood vessels by means of ionizing radiation|
|US6537192||Jun 5, 2000||Mar 25, 2003||Mentor Corporation||Automated radioisotope seed loader system for implant needles|
|US6539247||Dec 3, 2001||Mar 25, 2003||Varian Medical Systems, Inc.||Brachytherapy system for prostate cancer treatment with computer implemented systems and processes to facilitate pre-implantation planning and post-implantation evaluations with storage of multiple plan variations for a single patient|
|US6561980||Jul 21, 2000||May 13, 2003||Alpha Intervention Technology, Inc||Automatic segmentation of prostate, rectum and urethra in ultrasound imaging|
|US6582352||Jan 2, 2001||Jun 24, 2003||Schneider (Europe) A.G.||Medical appliance for treatment by ionizing radiation|
|US6599230||Mar 14, 2001||Jul 29, 2003||Scimed Life Systems, Inc.||Intravascular radiation delivery system|
|US6599231||Sep 11, 2000||Jul 29, 2003||Mentor Corporation||Loading clip for radioisotope seeds|
|US6616593||Jun 5, 2000||Sep 9, 2003||Mentor Corporation||Automated radioisotope seed cartridge|
|US6616629||Jun 14, 1999||Sep 9, 2003||Schneider (Europe) A.G.||Medical appliance with centering balloon|
|US6676590||Dec 8, 1997||Jan 13, 2004||Scimed Life Systems, Inc.||Catheter system having tubular radiation source|
|US6869390||Nov 13, 2001||Mar 22, 2005||Mentor Corporation||Automated implantation system for radioisotope seeds|
|US7022062 *||Aug 30, 2000||Apr 4, 2006||Murphy Brian B||Radioactive seed implantation system and method|
|US7041048 *||Oct 16, 2002||May 9, 2006||Sourcetech Medical, Llc||Apparatus and method for dose administration in brachytherapy|
|US7171255 *||Jul 2, 2001||Jan 30, 2007||Computerized Medical Systems, Inc.||Virtual reality 3D visualization for surgical procedures|
|US7187800||Aug 2, 2002||Mar 6, 2007||Computerized Medical Systems, Inc.||Method and apparatus for image segmentation using Jensen-Shannon divergence and Jensen-Renyi divergence|
|US7201715||Dec 23, 2002||Apr 10, 2007||Computerized Medical Systems, Inc.||Real time brachytherapy spatial registration and visualization system|
|US7229400||Jan 31, 2003||Jun 12, 2007||Mills Biopharmaceuticals Llc||Automated radioisotope seed loader system for implant needles|
|US7361134 *||Jan 24, 2003||Apr 22, 2008||University Of Wollongong||Method and apparatus for real time dosimetry|
|US7399269 *||Dec 2, 2002||Jul 15, 2008||Nucletron B.V.||Process, control program, treatment planning system and control system, and dose measuring system for brachytherapy|
|US7425194||Jun 17, 2003||Sep 16, 2008||Nucletron B.V.||Template-assembly for effecting radiation treatment in an animal body|
|US7438685 *||Nov 1, 2002||Oct 21, 2008||Computerized Medical Systems, Inc.||Apparatus and method for registration, guidance and targeting of external beam radiation therapy|
|US7504646||Aug 30, 2005||Mar 17, 2009||Bracco Diagnostics, Inc.||Containers for pharmaceuticals, particularly for use in radioisotope generators|
|US7567694||Jul 21, 2006||Jul 28, 2009||Tomotherapy Incorporated||Method of placing constraints on a deformation map and system for implementing same|
|US7574251||Jul 21, 2006||Aug 11, 2009||Tomotherapy Incorporated||Method and system for adapting a radiation therapy treatment plan based on a biological model|
|US7609809||Jul 21, 2006||Oct 27, 2009||Tomo Therapy Incorporated||System and method of generating contour structures using a dose volume histogram|
|US7634304||Jul 31, 2001||Dec 15, 2009||Mcgill University||Method and apparatus for lesion localization, definition and verification|
|US7639853||Jul 21, 2006||Dec 29, 2009||Tomotherapy Incorporated||Method of and system for predicting dose delivery|
|US7639854||Jul 21, 2006||Dec 29, 2009||Tomotherapy Incorporated||Method and system for processing data relating to a radiation therapy treatment plan|
|US7643661||Jan 5, 2010||Tomo Therapy Incorporated||Method and system for evaluating delivered dose|
|US7662097||Sep 20, 2005||Feb 16, 2010||Resonant Medical, Inc.||Radiotherapy treatment monitoring using ultrasound|
|US7668587 *||May 13, 2003||Feb 23, 2010||Spectros Corporation||Optical imaging of induced signals in vivo under ambient light conditions|
|US7672705||Mar 2, 2010||Resonant Medical, Inc.||Weighted surface-to-surface mapping|
|US7729744||Jul 20, 2004||Jun 1, 2010||Resonant Medical, Inc.||Verifying lesion characteristics using beam shapes|
|US7736293||Jul 22, 2005||Jun 15, 2010||Biocompatibles Uk Limited||Implants for use in brachytherapy and other radiation therapy that resist migration and rotation|
|US7773788||Jul 21, 2006||Aug 10, 2010||Tomotherapy Incorporated||Method and system for evaluating quality assurance criteria in delivery of a treatment plan|
|US7839972||Nov 23, 2010||Tomotherapy Incorporated||System and method of evaluating dose delivered by a radiation therapy system|
|US7874974||Jan 25, 2011||Biocompatibles Uk Limited||Delivery system and method for interstitial radiation therapy|
|US7874976||Sep 7, 2006||Jan 25, 2011||Biocompatibles Uk Limited||Echogenic strands and spacers therein|
|US7878964||Feb 1, 2011||Biocompatibles Uk Limited||Echogenic spacers and strands|
|US7899517 *||Mar 1, 2011||Nucletron B.V.||Real time radiation treament planning system|
|US7942803||Jan 21, 2010||May 17, 2011||Biocompatibles Uk Limited||Delivery system and method for interstitial radiation therapy|
|US7957507||Feb 24, 2006||Jun 7, 2011||Cadman Patrick F||Method and apparatus for modulating a radiation beam|
|US7959548||Jun 14, 2011||Core Oncology, Inc.||Automated implantation system for radioisotope seeds|
|US7972261||Jul 20, 2006||Jul 5, 2011||Biocompatibles Uk Limited||Devices to resist migration and rotation of implants used in brachytherapy and other radiation therapy|
|US7985172||Apr 27, 2007||Jul 26, 2011||Biocompatibles Uk Limited||After-loader devices and kits|
|US7988611||Nov 3, 2006||Aug 2, 2011||Biocompatibles Uk Limited||After-loader for positioning implants for needle delivery in brachytherapy and other radiation therapy|
|US8000442||Jul 19, 2005||Aug 16, 2011||Resonant Medical, Inc.||Calibrating imaging devices|
|US8021291||Sep 20, 2011||Biocompatibles Uk Limited||Markers for use in brachytherapy and other radiation therapy that resist migration and rotation|
|US8058632||Nov 15, 2011||Bracco Diagnostics, Inc.||Containers for pharmaceuticals, particularly for use in radioisotope generators|
|US8066627 *||Nov 29, 2011||Biocompatibles Uk Limited||Delivery system and method for interstitial radiation therapy using strands constructed with extruded strand housings|
|US8114007||Dec 15, 2008||Feb 14, 2012||Biocompatibles Uk Limited||Implants for use in brachytherapy and other radiation therapy that resist migration and rotation|
|US8135198||Aug 6, 2008||Mar 13, 2012||Resonant Medical, Inc.||Systems and methods for constructing images|
|US8187159||Feb 26, 2009||May 29, 2012||Biocompatibles, UK||Therapeutic member including a rail used in brachytherapy and other radiation therapy|
|US8189738||May 28, 2009||May 29, 2012||Elekta Ltd.||Methods and systems for guiding clinical radiotherapy setups|
|US8192345||Jan 21, 2009||Jun 5, 2012||Biocompatibles, UK||Cartridge for use with brachytherapy applicator|
|US8222616||Jul 17, 2012||Tomotherapy Incorporated||Method for adapting fractionation of a radiation therapy dose|
|US8229068||Jul 21, 2006||Jul 24, 2012||Tomotherapy Incorporated||System and method of detecting a breathing phase of a patient receiving radiation therapy|
|US8232535||Jul 31, 2012||Tomotherapy Incorporated||System and method of treating a patient with radiation therapy|
|US8249317||Jul 21, 2008||Aug 21, 2012||Eleckta Ltd.||Methods and systems for compensating for changes in anatomy of radiotherapy patients|
|US8301228||Jan 25, 2011||Oct 30, 2012||Nucletron Operations B.V.||Real time radiation treatment planning system|
|US8363784||Jan 29, 2013||Tomotherapy Incorporated||System and method of calculating dose uncertainty|
|US8364242||Jan 29, 2013||General Electric Company||System and method of combining ultrasound image acquisition with fluoroscopic image acquisition|
|US8366618||Dec 28, 2009||Feb 5, 2013||Elekta Ltd.||Radiotherapy treatment monitoring using ultrasound|
|US8401148||Mar 19, 2013||Tomotherapy Incorporated||Non-voxel-based broad-beam (NVBB) algorithm for intensity modulated radiation therapy dose calculation and plan optimization|
|US8406844||Mar 6, 2003||Mar 26, 2013||Tomotherapy Incorporated||Method for modification of radiotherapy treatment delivery|
|US8428690||Apr 23, 2013||General Electric Company||Intracardiac echocardiography image reconstruction in combination with position tracking system|
|US8442287||Aug 10, 2010||May 14, 2013||Tomotherapy Incorporated||Method and system for evaluating quality assurance criteria in delivery of a treatment plan|
|US8470294||Jun 25, 2010||Jun 25, 2013||Microspherix Llc||Flexible and/or elastic brachytherapy seed or strand|
|US8527032||Mar 27, 2008||Sep 3, 2013||General Electric Company||Imaging system and method of delivery of an instrument to an imaged subject|
|US8577115||Mar 4, 2009||Nov 5, 2013||Tomotherapy Incorporated||Method and system for improved image segmentation|
|US8744553||Sep 24, 2012||Jun 3, 2014||Nucletron Operations B.V.||Real-time radiation treatment planning system|
|US8767917||Jul 21, 2006||Jul 1, 2014||Tomotherapy Incorpoated||System and method of delivering radiation therapy to a moving region of interest|
|US8790235||Aug 7, 2009||Jul 29, 2014||Eckert & Ziegler Debig S.A.||Devices to resist migration and rotation of implants used in brachytherapy and other radiation therapy|
|US8795146||May 4, 2010||Aug 5, 2014||Eckert & Ziegler Bebig S.A.||Implants including spacers for use in brachytherapy and other radiation therapy that resist migration and rotation|
|US8803910||Aug 28, 2009||Aug 12, 2014||Tomotherapy Incorporated||System and method of contouring a target area|
|US8821835||Jun 13, 2013||Sep 2, 2014||Microspherix Llc||Flexible and/or elastic brachytherapy seed or strand|
|US8880145||Apr 14, 2008||Nov 4, 2014||Gmv Aerospace And Defence S.A.||Planning system for intraoperative radiation therapy and method for carrying out said planning|
|US8913716||Jan 11, 2013||Dec 16, 2014||Tomotherapy Incorporated||System and method of calculating dose uncertainty|
|US8929621||Dec 20, 2005||Jan 6, 2015||Elekta, Ltd.||Methods and systems for segmentation and surface matching|
|US8989842||Sep 25, 2007||Mar 24, 2015||General Electric Company||System and method to register a tracking system with intracardiac echocardiography (ICE) imaging system|
|US9061141||Sep 29, 2010||Jun 23, 2015||Tomotherapy Incorporated||Patient support device with low attenuation properties|
|US9248316||Sep 22, 2011||Feb 2, 2016||Elekta Ltd.||Feature tracking using ultrasound|
|US9381377||Apr 23, 2014||Jul 5, 2016||Nucletron Operations B.V.||Real time radiation treatment planning system|
|US20010041838 *||Jul 2, 2001||Nov 15, 2001||Holupka Edward J.||Virtual reality 3D visualization for surgical procedures|
|US20030018232 *||Nov 13, 2001||Jan 23, 2003||Mentor Corporation||Automated implantation system for radioisotope seeds|
|US20030065260 *||Jul 12, 2002||Apr 3, 2003||Alpha Intervention Technology, Inc.||Identification and quantification of needle and seed displacement departures from treatment plan|
|US20030112922 *||Nov 1, 2002||Jun 19, 2003||Computerized Medical Systems, Inc.||Apparatus and method for registration, guidance and targeting of external beam radiation therapy|
|US20030130573 *||Jul 26, 2002||Jul 10, 2003||Yan Yu||Method and device for optimization of preloaded brachytherapy needles|
|US20030135102 *||Dec 5, 2002||Jul 17, 2003||Burdette Everette C.||Method and system for registration and guidance of intravascular treatment|
|US20030139641 *||Jan 31, 2003||Jul 24, 2003||Mentor Corporation||Automated radioisotope seed loader system for implant needles|
|US20030212302 *||Jan 24, 2003||Nov 13, 2003||Anatoly Rozenfeld||Method and apparatus for real time dosimetry|
|US20030229282 *||Dec 23, 2002||Dec 11, 2003||Burdette Everette C.||Real time brachytherapy spatial registration and visualization system|
|US20030233123 *||May 30, 2003||Dec 18, 2003||Johann Kindlein||Real time radiation treament planning system|
|US20040010192 *||May 13, 2003||Jan 15, 2004||Spectros Corporation||Optical imaging of induced signals in vivo under ambient light conditions|
|US20040022438 *||Aug 2, 2002||Feb 5, 2004||Hibbard Lyndon S.||Method and apparatus for image segmentation using Jensen-Shannon divergence and Jensen-Renyi divergence|
|US20040034301 *||Jul 31, 2001||Feb 19, 2004||Tony Falco||Method and apparatus for lesion localization, definition and verification|
|US20040071323 *||Aug 23, 2001||Apr 15, 2004||Darzi Ara Warkes||Data recorder|
|US20040077919 *||Oct 16, 2002||Apr 22, 2004||Drobnik Christopher D.||Apparatus and method for dose administration in brachytherapy|
|US20040106840 *||Dec 2, 2002||Jun 3, 2004||Johann Kindlein||Process, control program, treatment planning system and control system, and dose measuring system for brachytherapy|
|US20050182316 *||Jul 29, 2004||Aug 18, 2005||Burdette Everette C.||Method and system for localizing a medical tool|
|US20050201516 *||Mar 6, 2003||Sep 15, 2005||Ruchala Kenneth J.||Method for modification of radiotherapy treatment delivery|
|US20050209499 *||Mar 22, 2005||Sep 22, 2005||Mentor Corporation||Automated implantation system for radioisotope seeds|
|US20060020195 *||Jul 20, 2004||Jan 26, 2006||Tony Falco||Verifying lesion characteristics using beam shapes|
|US20060036156 *||Jul 19, 2004||Feb 16, 2006||Martin Lachaine||Weighted surface-to-surface mapping|
|US20060036170 *||Jul 19, 2005||Feb 16, 2006||Martin Lachaine||Calibrating imaging devices|
|US20060064014 *||Sep 20, 2005||Mar 23, 2006||Tony Falco||Radiotherapy treatment monitoring using ultrasound|
|US20060235365 *||Jun 16, 2006||Oct 19, 2006||World Wide Medical Technologies, Llc||Delivery system and method for interstitial radiation therapy using strands constructed with extruded strand housings|
|US20060285639 *||May 10, 2006||Dec 21, 2006||Tomotherapy Incorporated||System and method of treating a patient with radiation therapy|
|US20070021642 *||Jul 20, 2006||Jan 25, 2007||Worldwide Medical Technologies Llc||Devices to resist migration and rotation of implants used in brachytherapy and other radiation therapy|
|US20070021643 *||Jul 22, 2005||Jan 25, 2007||World Wide Medical Technologies, Llc||Implants for use in brachytherapy and other radiation therapy that resist migration and rotation|
|US20070041494 *||Jul 21, 2006||Feb 22, 2007||Ruchala Kenneth J||Method and system for evaluating delivered dose|
|US20070041497 *||Jul 21, 2006||Feb 22, 2007||Eric Schnarr||Method and system for processing data relating to a radiation therapy treatment plan|
|US20070041499 *||Jul 21, 2006||Feb 22, 2007||Weiguo Lu||Method and system for evaluating quality assurance criteria in delivery of a treatment plan|
|US20070041500 *||Jul 21, 2006||Feb 22, 2007||Olivera Gustavo H||Radiation therapy imaging and delivery utilizing coordinated motion of gantry and couch|
|US20070043286 *||Jul 21, 2006||Feb 22, 2007||Weiguo Lu||Method and system for adapting a radiation therapy treatment plan based on a biological model|
|US20070140426 *||Dec 1, 2006||Jun 21, 2007||Steve Axelrod||Treatment of lesions or imperfections in mammalian skin or near-skin tissues or in or near other anatomic surfaces|
|US20070167699 *||Dec 20, 2005||Jul 19, 2007||Fabienne Lathuiliere||Methods and systems for segmentation and surface matching|
|US20070189591 *||Jul 21, 2006||Aug 16, 2007||Weiguo Lu||Method of placing constraints on a deformation map and system for implementing same|
|US20070195929 *||Jul 21, 2006||Aug 23, 2007||Ruchala Kenneth J||System and method of evaluating dose delivered by a radiation therapy system|
|US20070201613 *||Jul 21, 2006||Aug 30, 2007||Weiguo Lu||System and method of detecting a breathing phase of a patient receiving radiation therapy|
|US20070265488 *||Nov 3, 2006||Nov 15, 2007||Worldwide Medical Technologies Llc||After-loader for positioning implants for needle delivery in brachytherapy and other radiation therapy|
|US20080064953 *||Sep 10, 2007||Mar 13, 2008||Tony Falco||Incorporating Internal Anatomy In Clinical Radiotherapy Setups|
|US20080219405 *||Sep 6, 2006||Sep 11, 2008||Tony Falco||System and method for patient setup for radiotherapy treatment|
|US20080283771 *||Apr 1, 2008||Nov 20, 2008||General Electric Company||System and method of combining ultrasound image acquisition with fluoroscopic image acquisition|
|US20080287803 *||Apr 1, 2008||Nov 20, 2008||General Electric Company||Intracardiac echocardiography image reconstruction in combination with position tracking system|
|US20090022383 *||Jul 21, 2008||Jan 22, 2009||Tony Falco||Methods and systems for compensating for changes in anatomy of radiotherapy patients|
|US20090024030 *||Jul 21, 2008||Jan 22, 2009||Martin Lachaine||Methods and systems for guiding the acquisition of ultrasound images|
|US20090041200 *||Jul 26, 2008||Feb 12, 2009||Tomotherapy Incorporated||Radiation therapy imaging and delivery utilizing coordinated motion of jaws, gantry, and couch|
|US20090041323 *||Aug 6, 2008||Feb 12, 2009||Martin Lachaine||Systems and Methods for Constructing Images|
|US20090099402 *||Dec 15, 2008||Apr 16, 2009||Biocompatibles Uk Limited||Implants for use in brachytherapy and other radiation therapy that resist migration and rotation|
|US20090105588 *||Sep 26, 2008||Apr 23, 2009||Board Of Regents, The University Of Texas System||Real-Time Ultrasound Monitoring of Heat-Induced Tissue Interactions|
|US20090110145 *||Oct 27, 2008||Apr 30, 2009||Tomotherapy Incorporated||Method for adapting fractionation of a radiation therapy dose|
|US20090124846 *||Jan 21, 2009||May 14, 2009||Biocompatibles Uk Limited||Anchor seed cartridge for use with brachytherapy applicator|
|US20090124894 *||Jan 21, 2009||May 14, 2009||Biocompatibles Uk Limited||Markers for use in brachytherapy and other radiation therapy that resist migration and rotation|
|US20090129989 *||Jan 23, 2009||May 21, 2009||Bracco Diagnostics, Inc.||Containers for pharmaceuticals, particularly for use in radioisotope generators|
|US20090149692 *||Feb 18, 2009||Jun 11, 2009||Biocompatibles Uk Limited||Implants for use in brachytherapy and other radiation therapy that resist migration and rotation|
|US20090216063 *||Jan 28, 2009||Aug 27, 2009||Biocompatibles Uk Limited||Bio-absorbable brachytherapy strands|
|US20090226060 *||Mar 4, 2009||Sep 10, 2009||Gering David T||Method and system for improved image segmentation|
|US20090312594 *||Aug 7, 2009||Dec 17, 2009||Biocompatibles Uk Limited|
|US20100008467 *||Jan 14, 2010||Chantal Dussault||Methods and Systems for Guiding Clinical Radiotherapy Setups|
|US20100053208 *||Aug 28, 2009||Mar 4, 2010||Tomotherapy Incorporated||System and method of contouring a target area|
|US20100054413 *||Aug 28, 2009||Mar 4, 2010||Tomotherapy Incorporated||System and method of calculating dose uncertainty|
|US20100099989 *||Dec 28, 2009||Apr 22, 2010||Tony Falco||Radiotherapy Treatment Monitoring Using Ultrasound|
|US20100106026 *||Dec 31, 2009||Apr 29, 2010||Benaron David A||Optical imaging of induced signals in vivo under ambient light conditions|
|US20100121130 *||Jan 21, 2010||May 13, 2010||Biocompatibles Uk Limited||Delivery system and method for interstitial radiation therapy|
|US20100228116 *||Mar 3, 2010||Sep 9, 2010||Weiguo Lu||System and method of optimizing a heterogeneous radiation dose to be delivered to a patient|
|US20100261946 *||Jun 25, 2010||Oct 14, 2010||Microspherix Llc||Flexible and/or elastic brachytherapy seed or strand|
|US20110009742 *||Jan 13, 2011||Martin Lachaine||Adaptive radiotherapy treatment using ultrasound|
|US20110052036 *||Apr 14, 2008||Mar 3, 2011||Gmv Aerospace And Defence S.A.||Planning system for intraoperative radiation therapy and method for carrying out said planning|
|US20110107515 *||Sep 29, 2010||May 12, 2011||Brunker Bradley J||Patient support device with low attenuation properties|
|US20110112351 *||Aug 10, 2010||May 12, 2011||Fordyce Ii Gerald D||Method and system for evaluating quality assurance criteria in delivery of a treatment plan|
|US20110122997 *||Oct 29, 2010||May 26, 2011||Weiguo Lu||Non-voxel-based broad-beam (nvbb) algorithm for intensity modulated radiation therapy dose calculation and plan optimization|
|US20130246081 *||May 2, 2012||Sep 19, 2013||Richard Auer||Systems and Methods for Supplementing Patient and Provider Interactions to Increase Patient Adherence|
|US20140303423 *||Sep 25, 2012||Oct 9, 2014||Koninklijke Philips N.V.||Medical apparatus for displaying the catheter placement position|
|CN103889507A *||Sep 25, 2012||Jun 25, 2014||皇家飞利浦有限公司||Medical apparatus for displaying the catheter placement position|
|EP1374949A1||Jun 17, 2002||Jan 2, 2004||Nucletron B.V.||Real time radiation treatment planning system|
|EP1380319A1 *||Jul 11, 2002||Jan 14, 2004||Nucletron B.V.||Urethral probe device|
|WO1996025881A1 *||Feb 8, 1996||Aug 29, 1996||Groenningsaeter Aage||Method for ultrasound guidance during clinical procedures|
|WO1996025882A1 *||Feb 22, 1995||Aug 29, 1996||Groenningsaeter Aage||Method for ultrasound guidance during clinical procedures|
|WO1999039628A1 *||Feb 2, 1999||Aug 12, 1999||Emory University||Systems and methods for providing radiation therapy and catheter guides|
|WO2000025865A1 *||Oct 26, 1999||May 11, 2000||University Of Rochester||Prostate implant planning engine for radiotherapy|
|WO2001082995A3 *||Apr 12, 2001||Apr 4, 2002||Alpha Intervention Technology||Identification and quantification of needle displacement|
|WO2007014093A2 *||Jul 21, 2006||Feb 1, 2007||Tomotherapy Incorporated||Method and system for processing data relating to a radiation therapy treatment plan|
|WO2007014093A3 *||Jul 21, 2006||Dec 6, 2007||Jason Haimerl||Method and system for processing data relating to a radiation therapy treatment plan|
|WO2007064900A2 *||Dec 1, 2006||Jun 7, 2007||Xoft, Inc.||Treatment of lesions or imperfections in mammalian skin or near-skin tissues or in or near other anatomic surfaces|
|WO2007064900A3 *||Dec 1, 2006||Apr 30, 2009||Steve Axelrod||Treatment of lesions or imperfections in mammalian skin or near-skin tissues or in or near other anatomic surfaces|
|WO2009045885A2 *||Sep 26, 2008||Apr 9, 2009||Board Of Regents, The University Of Texas System||Real-time ultrasound monitoring of heat-induced tissue interactions|
|WO2009127747A1||Apr 14, 2008||Oct 22, 2009||Gmv Aerospace And Defence S.A.||Planning system for intraoperative radiation therapy and method for carrying out said planning|
|U.S. Classification||600/7, 600/3|
|Cooperative Classification||A61N5/103, A61N5/1027|
|Sep 15, 1998||REMI||Maintenance fee reminder mailed|
|Feb 21, 1999||LAPS||Lapse for failure to pay maintenance fees|
|May 4, 1999||FP||Expired due to failure to pay maintenance fee|
Effective date: 19990221