Search Images Maps Play YouTube News Gmail Drive More »
Sign in
Screen reader users: click this link for accessible mode. Accessible mode has the same essential features but works better with your reader.

Patents

  1. Advanced Patent Search
Publication numberUS5599527 A
Publication typeGrant
Application numberUS 08/340,568
Publication dateFeb 4, 1997
Filing dateNov 14, 1994
Priority dateNov 14, 1994
Fee statusPaid
Also published asCA2162536A1, CA2162536C, DE69529552D1, EP0712624A2, EP0712624A3, EP0712624B1, US5698182, US5730959
Publication number08340568, 340568, US 5599527 A, US 5599527A, US-A-5599527, US5599527 A, US5599527A
InventorsDonald P. Hsu, Rajnish Kohli, Michael Prencipe
Original AssigneeColgate-Palmolive Company
Export CitationBiBTeX, EndNote, RefMan
External Links: USPTO, USPTO Assignment, Espacenet
Dentifrice compositions having improved anticalculus properties
US 5599527 A
Abstract
A storage stable oral composition which is effective against calculus which contains an orally acceptable vehicle having incorporated therein an effective anticalculus combination of about 0.5 to about 2% by weight of a water soluble pyrophosphate salt and about 0.5 to about 3% by weight of a water soluble polyphosphate salt. The presence in the composition of polyvalent metal compounds and fluoride compounds do not affect the stability of the composition as well as reactive ingredients such as peroxide and bicarbonate compounds.
Images(5)
Previous page
Next page
Claims(21)
What is claimed is:
1. An aqueous fluoride gel or paste which is storage stable and is effective against calculus, the dentifrice comprising a vehicle containing about 5 to about 9% by weight water, having incorporated therein a water soluble fluoride compound providing about 10 to 2,000 ppm fluoride ion and a combination of about 0.5 to no more than about 3% by weight of a water soluble alkali metal polyphosphate and about 0.5 to no more than about 2.0% by weight of a water soluble alkali metal pyrophosphate which composition is stable and effective to reduce calculus formation on teeth in the oral cavity.
2. The dentifrice composition of claim 1 wherein the water soluble alkali polyphosphate is sodium tripolyphosphate.
3. The dentifrice composition of claim 1 wherein the alkali metal pyrophosphate is sodium pyrophosphate.
4. The dentifrice composition of claim 1 wherein a polyvalent metal compound is incorporated in the vehicle.
5. The dentifrice composition of claim 4 wherein the polyvalent metal compound is a polyvalent metal peroxide.
6. The dentifrice composition of claim 5 wherein the polyvalent metal peroxide is calcium peroxide.
7. The dentifrice composition of claim 1 wherein a bicarbonate compound is incorporated in the vehicle.
8. The dentifrice composition of claim 7 wherein the bicarbonate compound is sodium bicarbonate.
9. The dentifrice composition of claim 1 wherein the fluoride compound is sodium monofluorophosphate.
10. The dentifrice composition of claim 1 wherein there is incorporated in the vehicle a polyvalent compound, a peroxide compound, a bicarbonate compound and a fluoride compound.
11. A method for reducing calculus of those susceptible of forming calculus and for treating diseases of the oral cavity by applying to teeth in the cavity an aqueous fluoride gel or paste comprising a vehicle containing about 5 to about 9% by weight water having incorporated therein a water soluble fluoride compound providing about 10 to 2000 ppm fluoride ion and a combination of about 0.5 to no more than about 2% by weight of a water soluble alkali metal pyrophosphate and about 0.5 to no more than about 3% by weight of water soluble alkali metal polyphosphate.
12. The method of claim 11 wherein the water soluble alkali polyphosphate is sodium tripolyphosphate.
13. The method of claim 11 wherein the alkali metal pyrophosphate is sodium pyrophosphate.
14. The method of claim 11 wherein a polyvalent metal compound is incorporated in the vehicle.
15. The method of claim 14 wherein the polyvalent metal compound is a polyvalent metal peroxide.
16. The method of claim 15 wherein the polyvalent metal peroxide is calcium peroxide.
17. The method of claim 11 wherein a bicarbonate compound is incorporated in the vehicle.
18. The method of claim 17 wherein the bicarbonate compound is sodium bicarbonate.
19. The method of claim 11 wherein the fluoride compound is sodium monofluorophosphate.
20. The method of claim 11 wherein there is incorporated in the vehicle a polyvalent metal compound, a peroxide compound, a bicarbonate compound and a fluoride compound.
21. A dentifrice composition which is storage stable and is effective against calculus, the dentifrice comprising an aqueous gel or paste vehicle having incorporated therein (A) sodium bicarbonate (B) about 0.25 to about 5% by weight of a calcium, magnesium or zinc metal peroxide and mixtures thereof (C) about 0.5 to no more than about 2.0% by weight of sodium or potassium pyrophosphate and mixtures thereof (D) about 0.5 to no more than about 3% by weight of sodium or potassium polyphosphate and mixtures thereof (E) sodium or potassium fluoride or monofluorophosphate and mixtures thereof, and (F) water, maintained at a concentration of from about 5% to less than about 9% by weight, the combination being effective to reduce the formation of calculus on teeth in the oral cavity.
Description
BACKGROUND OF THE INVENTION

1. Field of the Invention

The invention relates generally to a dentifrice composition and more particularly to a dentifrice composition which contains reactive ingredients and exhibits improved anticalculus properties.

2. The Prior Art

It has been found to be very desirable to incorporate peroxide compounds in dentifrice compositions, the efficacy of peroxide compounds in oral hygiene having long been recognized. Such compounds have been proven effective in the treatment of gingivitis, periodontitis and in combating plaque. Additionally, peroxide compounds have been utilized for oral cosmetic purposes such as tooth whitening which results from bleaching and cleansing of tooth surfaces. Examples of the prior art disclosing peroxide containing dentifrices are found in the disclosures of U.S. Pat. No. 4,971,782, U.S. Pat. No. 4,897,258 and U.S. Pat. No. 4,837,008.

Although the presence of peroxide ingredients in the dentifrice provides antiplaque and whitening efficacy, an improvement in the anticalculus (i.e., antitartar) efficacy of the dentifrice is desired by the art.

Included in the wide variety of chemical agents disclosed by the prior art as being effective as anticalculus agents are the water soluble polyphosphate and pyrophosphate salts. For example, U.S. Pat. No. 4,923,684 and U.S. Pat. No. 4,985,236 disclose the use of a water-soluble alkali metal tripolyphosphate as an anticalculus agent in dentifrice compositions. The patent discloses that to be storage stable, the tripolyphosphate salt must be incorporated in the dentifrice at a concentration of at least 4% by weight, the dentifrice having an alkaline pH, for example, a pH of 8-10. At concentrations less than 4% by weight, for example, 3% by weight, the patent teaches that the polyphosphate salt is unstable in the stored dentifrice composition.

U.S. Pat. No. 4,684,518 discloses that water soluble alkali metal pyrophosphate salts are effective as anticalculus agents when present in dentifrice compositions at a concentration sufficient to provide at least 1.5% P2 O7 -4 anion.

U.S. Pat. No. 5,176,900 discloses a dentifrice composition containing an anticalculus combination of a water soluble tripolyphosphate salt sufficient to provide 0.5-7.5% P3 O10 anion and a water soluble orthophosphate salt sufficient to provide from 0.2-5% orthophosphate anion, the combination being storage stable at a pH below 8.0.

SUMMARY OF THE INVENTION

In accordance with the present invention, there is provided a storage stable oral composition which is effective against calculus which contains an orally acceptable vehicle having incorporated therein an effective anticalculus combination of about 0.5 to about 2% by weight of a water soluble pyrophosphate salt and about 0.5 to about 3% by weight of a water soluble polyphosphate salt.

As will hereinafter be demonstrated, a dentifrice containing a combination of water soluble pyrophosphate and polyphosphate salts at the concentrations indicated above exhibit an anticalculus efficacy at least equivalent to that exhibited by presently available commercial dentifrice products delivering an anticalculus benefit.

In addition to the anticalculus efficacy, it has also been unexpectedly discovered that when the amount of water present in the dentifrice composition is maintained at a concentration of less than about 9% by weight and preferably about 5 to about 8% by weight, the free pyrophosphate ion concentration as well as any free fluoride ion concentration incorporated in the dentifrice is maintained at substantially the original levels of incorporation in the dentifrice during storage, in spite of the presence in the dentifrice of reactive ingredients such as peroxide and bicarbonate compounds as well as polyvalent metal cations, such as calcium ion, which is normally incompatible with water soluble fluoride and pyrophosphate salts as these polyvalent cations normally interact to form water insoluble salts which are inactive in the aqueous environment of the oral cavity.

DESCRIPTION OF THE PREFERRED EMBODIMENTS

The vehicle used to prepare the dentifrice composition of the present invention may be substantially anhydrous or contain limited amounts of water as well as a suitable humectant such as glycerin, sorbitol, polyethylene glycol, or any suitable mixture thereof. Limited amounts of water may be included in the vehicle of the dentifrice composition and preferably at a concentration of no more than about 9% by weight of the composition and most preferably about 5 to about 8% by weight. When water is present in the dentifrice composition in an amount in excess of about 9% by weight, the stability of the dentifrice composition is adversely affected.

The proportion of vehicle used to prepare the dentifrice composition of the present invention is generally within the range of about 40 to about 70% by weight of the dentifrice composition of this invention and preferably about 50 to about 65% by weight of the dentifrice composition. Glycerin is present in the dentifrice vehicle of the present invention at a concentration of about 10 to about 60% by weight and preferably about 15 to about 40% by weight.

A surfactant is used in the preparation of dentifrice composition of the present invention to aid in the thorough dispersion of the dentifrice composition throughout the oral cavity when applied thereto as well as to improve the cosmetic acceptability and detersive and foaming properties of the dentifrice. Among the organic surfactants useful in the practice of the present invention are salts of the higher alkyl sulfates, such as sodium lauryl sulfate (SLS) or other suitable alkyl sulfate having 8 to 18 carbon atoms in the alkyl group; sodium lauryl sulfoacetate, salts of sulfonated monoglycerides of higher fatty acids, such as sodium coconut monoglyceride sulfonate or other suitable sulfonated monoglycerides of a fatty acids of 10 to 18 carbon atoms; salts of amides of higher fatty acid, e.g., 12 to 16 carbon atom acids, with lower aliphatic amino acids, such as sodium-N-methyl-N-palmitoyl tauride, sodium N-lauroyl-, N-myristoyl- and N-palmitoyl sarcosinates; salts of the esters of such fatty acids with isothionic acid or with glycerol monosulfate, such as the sodium salt of monosulfated monoglyceride of hydrogenated coconut oil fatty acids; salts of olefin sulfonates, e.g. alkene sulfonates or hydroxalkene sulfonates or mixtures thereof having 12 to 16 carbon atoms in the carbon chain of the molecule; and soaps of higher fatty acids, such as those of 12 to 18 carbon atoms, e.g., coconut fatty acids. The cation of the salt may be sodium potassium or mono-, di or triethanol amine.

The surfactant is included in the dentifrice vehicle of the present invention at a concentration of about 0.5 to about 3.0% by weight and preferably about 1.0 to about 2.0% by weight.

Polishing agents are incorporated in dentifrice composition of the present invention and preferred polishing agents are siliceous materials, such as silica, and will normally have a mean particle size up to about 10 microns and a very high surface area, e.g. in the range of 150-750 square meters/gram. A preferred silica is a precipitated amorphous hydrated silica, such as Sorbosil AC-35 marketed by Crosfield Chemicals, or Zeodent 115 from J. M. Huber Company but other polishing agents may also be employed, including sodium bicarbonate, calcium carbonate, sodium metaphosphate, potassium metaphosphate, tricalcium phosphate, calcium phosphate dihydrate, anhydrous dicalcium phosphate, calcium pyrophosphate, magnesium orthophosphate, trimagnesium phosphate, alumina trihydrate, aluminum silicate, zirconium silicate, calcined alumina and bentonite.

The polishing agent is present in the dentifrice composition of the present invention at a concentration of about 10 to about 30% by weight and preferably about 5 to about 25% by weight.

Bicarbonate compounds, when included the dentifrice of the present invention, are included at a concentration of about 5 to about 20% by weight and preferably about 8 to about 15% by weight. When used at these concentrations the pH of the dentifrice is generally in the range of about 8 to about 10. The particle size of the bicarbonate compound can range from about 10 to about 300 microns although a particle size of 20-60 microns is preferred, the smaller particle size bicarbonate being more readily dispersed in the anhydrous vehicle.

Inorganic thickeners may be included in the dentifrices of the present invention and include fumed silicas such as Cab-o-sil available from Cabot Corporation, and thickening silicas including those available from W. R. Grace designated Sylox 15.

Organic thickeners such as natural and synthetic gums and colloids may also be incorporated in the dentifrice composition of the present invention, particularly when water in amounts up to about 9% by weight are present in the dentifrice component. Examples of such thickeners include carrageenan (Irish moss), xanthan gum and sodium carboxymethyl cellulose, starch, polyvinylpyrrolidone, hydroxyethylpropylcellulose, hydroxybutyl methyl cellulose, hydroxypropyl methyl cellulose, and hydroxyethyl cellulose.

The inorganic or organic thickener may be incorporated in the compositions of the present invention at a concentration of about 0.05 to about 2% by weight and preferably about 0.1 to about 1.5% by weight.

Peroxide compounds may be used as an ingredient in the dentifrice composition of the present invention and when added to the dentifrice composition are present in the dentifrice at a concentration of about 0.25 to about 5% by weight and preferably about 0.5 to about 2.0% by weight. Peroxide compounds suitable for use in the practice of the present invention include metal peroxides such as calcium peroxide, magnesium peroxide and zinc peroxide.

Fluoride-providing salts having anti-caries efficacy may also be incorporated in the dentifrice of the present invention and are characterized by their ability to release fluoride ions in water. It is preferable to employ a water-soluble salt fluoride providing about 10-2,000 ppm of fluoride ion, and preferably about 1000-1500 ppm of fluoride ion. Among these materials are water-soluble inorganic metal salts, for example, sodium fluoride, potassium fluoride, sodium monofluorophosphate, and sodium fluorosilicate. Sodium fluoride and sodium monofluorophosphate are preferred fluoride-providing salts.

Pyrophosphate salts having anticalculus efficacy useful in the practice of the present invention include water soluble salts such as dialkali or tetra-alkali metal pyrophosphate salts such as Na4 P2 O7 (TSPP), K4 P2 O7, Na2 K2 P2 O7, Na2 H2 P2 O7 and K2 H2 P2 O7. Polyphosphate salts include the water soluble alkali metal tripolyphosphates such as sodium tripolyphosphate (STPP) and potassium tripolyphosphate.

The pyrophosphate salts are incorporated in the dentifrice composition of the present invention at a concentration of about 0.5 to about 2.0% by weight, and preferably about 1.5 to about 2% by weight and the polyphosphate salts are incorporated in the dentifrice composition of the present invention at a concentration of about 1.0 to about 3.0% by weight and preferably about 2 to about 3% by weight.

Colorants such as pigments and dyes may be used in the practice of the present invention. Pigments include non-toxic, water insoluble inorganic pigments such as titanium dioxide and chromium oxide greens, ultramarine blues and pinks and ferric oxides as well as water insoluble dye lakes prepared by extending calcium or aluminum salts of FD&C dyes on alumina such as FD&C Green #1 lake, FD&C Blue #2 lake, FD&C R&D #30 lake and FD&C # Yellow 15 lake. The pigments have a particle size in the range of 5-1000 microns, preferably 250-500 microns, and are present at a concentration of 0.5 to 3% by weight.

Dyes used in the practice of the present invention are generally food color additives presently certified under the Food Drug & Cosmetic Act for use in food and ingested drugs, including dyes such as FD&C Red No. 3 (sodium salt of tetraiodofluorescein), FD&C Yellow No. 5 (sodium salt of 4-p-sulfophenylazo-1-p-sulfophenyl-5-hydroxypyrazole-3 carboxylic acid), FD&C Yellow No. 6 (sodium salt of p-sulfophenylazo-B-naphtol-6-monosulfonate), FD&C Green No. 3 (disodium salt of 4-{[4-(N-ethyl-p-sulfobenzylamino)-phenyl]-(4-hydroxy-2-sulfoniumphenyl)-methylene}-[1-(N-ethyl-N-p-sulfobenzyl)-Δ-3,5-cyclohexadienimine], FD&C Blue No. 1 (disodium salt of dibenzyldiethyldiaminotriphenylcarbinol trisulfonic acid anhydrite), FD&C Blue No. 2 (sodium salt of disulfonic acid of indigotin) and mixtures thereof in various proportions. The concentration of the dye for the most effective result in the present invention is present in the dentifrice composition in an amount from about 0.0005 percent to about 2 percent of the total weight.

Any suitable flavoring or sweetening material may also be incorporated in the dentifrice composition of the present invention. Examples of suitable flavoring constituents are flavoring oils, e.g., oils of spearmint, peppermint, wintergreen, sassafras, clove, sage, eucalyptus, marjoram, cinnamon, lemon, and orange, and methyl salicylate. Suitable sweetening agents include sucrose, lactose, maltose, sorbitol, xylitol, sodium cyclamate, perillartine, and sodium saccharin. Suitably, flavor and sweetening agents may together comprise from 0.01% to 5% or more of the preparations.

Various other materials may be incorporated into the dentifrice composition of this invention. Non-limiting examples thereof include preservatives, silicones and chlorophyll compounds, antibacterial agents such as chlorohexidene, halogenated diphenyl ethers such as Triclosan, desensitizing agents such as potassium nitrate and potassium citrate and mixtures thereof. These adjuvants are incorporated in the dentifrice components in amounts which do not substantially adversely affect the properties and characteristics desired, and are selected and used in proper amounts, depending upon the particular type of dentifrice component involved.

To prepare the dentifrice composition of the present invention, the humectants e.g. glycerin and glycol humectants and sweetener are dispersed in a conventional mixer until the mixture becomes a homogeneous gel phase. Into the gel phase are added a colorant, the anticalculus agents and a fluoride anticaries agent. These ingredients are mixed until a homogeneous phase is obtained. Thereafter the thickener, polishing agent, reactive ingredient such as peroxide, bicarbonate salts, flavor and surfactant ingredients are added and the ingredients mixed at high speed under vacuum of about 20-100 mm Hg. The resultant product is a homogeneous, semi-solid, extrudable paste product.

The following examples illustrate this invention further. All proportions and amounts therein and elsewhere in this specification are by weight unless otherwise indicated.

EXAMPLE I

To demonstrate the anticalculus efficacy of the composition of the present invention, a dentifrice composition of the present invention designated "Composition A" was prepared containing 2% TSPP and 3% STPP following the procedure previously described containing the ingredients listed in Table I below.

              TABLE 1______________________________________Composition AIngredients______________________________________Glycerin            25.00%PEG 600             3.00Propylene Glycol    17.94Na Saccharin        0.50Xanthan             0.20Carboxymethyl Cellulose               0.20MFP                 0.76TSPP                2.00*STPP                3.00TiO2           0.50Zeodent 115         21.00F D & C Green #3 Dye               0.20(1%) Soln.Sylox 15            2.50NaHCO3         12.00CaO2           0.50Flavor              1.0SLS                 1.70Water               6.00Na2 CO3   2.00______________________________________ *2% TSPP provides 1.3% P2 O7 -4 ion

To determine whether the presence of the combination of TSPP and STPP at the concentration levels present in Composition A (2% TSPP and 3% STPP) would provide acceptable anticalculus efficacy, in vitro testing of Composition A was conducted in accordance with the following procedure:

Composition A was diluted with water and centrifuged to obtain a supernatant which was diluted 20 with water and hydroxy apatite seeds (68 m2 /g) were then suspended in the diluted supernatant overnight at 37 C. The treated seeds were then separated from the supernatant and added to a crystal growth solution containing 1.06 mm CaCl2 and 0.63 mM KH2 PO4 and 150 mM NaCl.

The pH of the growth solution was recorded as a function of time, a pH drop being an indication of potential HAP crystal (i.e. tartar) growth.

The results of the in vitro test are recorded in Table II below. For purposes of comparison, the test was repeated except the dentifrices tested included a commercially available anticalculus toothpaste designated "Commercial Toothpaste I" and a second commercial toothpaste which did not claim an anticalculus benefit designated "Commercial Toothpaste II" sold by different manufacturers as well as a control dentifrice identical in composition to Composition A except that TSPP and STPP were not included in the composition, was also tested.

The results obtained with the commercial and control toothpastes are also recorded in Table II below.

              TABLE II______________________________________          pHDentifrice       0 min.    15 min. 30 min.______________________________________Composition A    7.38      7.25    7.22Commercial Toothpaste I            7.37      7.07    7.04Commercial Toothpaste II            7.38      6.48    6.40Control          7.38      6.88    6.81______________________________________

The results recorded in Table II indicate that Composition A sustained a pH drop of a magnitude less than the pH drop sustained by the anticalculus Commercial Toothpastes or the Control dentifrice indicating that Composition A would provide an anticalculus efficacy greater than the Commercial Toothpastes.

EXAMPLE II

Composition B having the composition listed in the Table III below were prepared following the procedure of Example I. Dentifrices B was then loaded into a plastic laminated tube, sealed and then aged at 105 F. for 2 months. The plastic laminated tube contents were analyzed after the aging period. The analysis results are summarized in Table IV below.

              TABLE III______________________________________Composition BIngredient           wt. %______________________________________Glycerin             25.2486Zeodent 115          21.0000Propylene Glycol     17.8900Sodium Bicarbonate   12.0000Deionized Water      6.0000Polyethylene Glycol 600                3.0000Sodium Tripolyphosphate                3.0000Hydrated Amorphous Silica                2.5000Na2 CO3    2.0000Tetrasodium Pyrophosphate                2.0000Sodium Lauryl Sulfate                1.7000Sodium Monofluorophosphate                0.760Flavor               1.00Sodium Saccharin     0.5000Titanium Dioxide     0.5000Calcium Peroxide     0.5000Xanthan Gum          0.2000Sodium Carboxymethyl Cellulose                0.2000F D & C Green #3 Dye 0.0014TOTAL                100.0000______________________________________

              TABLE IV______________________________________Aging of Composition B at 105 F.Initial          2 Months          %                       %%      %       Soluble   %      %      SolubleTSPP   STPP    Fluoride  TSPP   STPP   Fluoride______________________________________1.8    3.1     0.096     2.0    2.7    0.097______________________________________

The results recorded in Table IV indicate that Composition B is substantially storage stable with little or no change in the concentration of TSPP, STPP or soluble fluoride ingredients.

Patent Citations
Cited PatentFiling datePublication dateApplicantTitle
US4897258 *Jan 28, 1988Jan 30, 1990Peroxydent GroupPeriodontal composition and method
US4980154 *Jun 23, 1988Dec 25, 1990Norman GordonTooth and gum dentifrice composition and method of making same
US5041280 *Oct 1, 1987Aug 20, 1991Epilady Usa, Inc.Toothpaste composition for stain removal
US5372803 *Sep 2, 1993Dec 13, 1994Chesebrough-Pond's Usa Co., Division Of Conopco, Inc.Dental compositions with zinc and bicarbonate salts
Non-Patent Citations
Reference
1 *Featherstone et al WO/PCT 9319728 (Oct. 14, 1993) Derwent p. 70, L153 3 of 17, GA. 119:256324 p. 33 L117 10 of 91.
2 *Gordon U.S. 4980154 (Dec. 25, 1990) GA. 114:234892 pp. 43 44 L117 36 of 91.
3Gordon U.S. 4980154 (Dec. 25, 1990) GA. 114:234892 pp. 43-44 L117 36 of 91.
4 *Ingram EP 295116 (Dec. 14, 1988) Derwent pp. 81 82 L154 12 of 17, GA. 110:198970 p. 49 L117 50 of 91.
5Ingram EP 295116 (Dec. 14, 1988) Derwent pp. 81-82 L154 12 of 17, GA. 110:198970 p. 49 L117 50 of 91.
6 *Lion Corp. JP 59001409 (Jan. 6, 1984) Derwent p. 87 L154 15 of 17.
7 *Rudy et al U.S. 4897258 (Jan. 30, 1990) GA. 113:46144 p. 46 L117 42 of 91.
8 *Smigel U.S. 5041280 (Aug. 20, 1991) GA. 115:189513 p. 41 L117 31 of 91.
9 *Williams et al U.S. 5372803 (Dec. 13, 1994) GA. 122:89159 p. 29 L117 2 of 91.
Referenced by
Citing PatentFiling datePublication dateApplicantTitle
US5690913 *Jul 30, 1996Nov 25, 1997Colgate Palmolive CompanyStriped tootpaste, color stability during storage
US5698182 *Oct 22, 1996Dec 16, 1997Colgate Palmolive CompanyDentifrice composition containing calcium peroxide having heightened tooth whitening effect
US5730959 *Jan 24, 1997Mar 24, 1998Colgate Palmolive CompanyMixture containing water solubility pyrophosphate salt and polyphosphate salt
US5766574 *Nov 15, 1996Jun 16, 1998Colgate Palmolive CompanyDual component tooth whitening dentifrice
US5814303 *Sep 17, 1997Sep 29, 1998Chesebrough-Pond's Usa Co., Division Of Conocpo, Inc.Dental product
US5814304 *Jul 10, 1997Sep 29, 1998Colgate Palmolive CompanyStorage stability, alumina abrasive, hydrogen peroxide, antioxidant, metal chelating agent
US5820852 *Nov 26, 1996Oct 13, 1998The Proctor & Gamble CompanyOral compositions containing fluoride, pyrophosphate, and peroxide
US5820854 *Mar 27, 1997Oct 13, 1998The Procter & Gamble CompanyHigh molecular weight polyoxyethylene and aqueous carriers having a high ionic strength
US5849269 *Nov 26, 1996Dec 15, 1998The Procter & Gamble CompanyOral compositions containing fluoride, pyrophosphate, peroxide, and nonionic and/or amphoteric surfactants
US5855871 *Aug 12, 1997Jan 5, 1999Colgate-Palmolive CompanyMixing to use
US5855875 *Jul 20, 1998Jan 5, 1999Chesebrough-Pond's Usa Co., Division Of Conopco, Inc.Dental product
US6120754 *Dec 21, 1998Sep 19, 2000Chesebrough-Pond's Usa Co., Division Of Conopco, Inc.Remineralization of teeth
US6180089 *Jan 21, 1999Jan 30, 2001Colgate-Palmolive CompanyEliminates or reduces discomfort and pain associated with dentinal hypersensitivity
US6187293 *Apr 27, 1999Feb 13, 2001Fmc CorporationProcess for making toothpaste using low levels of carrageenan
US6207139Sep 13, 1999Mar 27, 2001Unilever Home & Personal Care Usa, Division Of Conopco, Inc.Mixture of peroxide, calcium phosphate and halogen compound
US6214321Mar 29, 2000Apr 10, 2001Chesebrough-Pond's Usa Co., Division Of Conopco, Inc.Oral product comprising first mixture of a water soluble calcium phosphate salt or calcium and phosphate salts in a carrier, the ph less than 7; and second mixture of alkaline material and fluoride source in a carrier at alkaline ph
US6241974 *Apr 22, 1997Jun 5, 2001The Procter & Gamble CompanyFluoride stability
US6248310Mar 29, 2000Jun 19, 2001Chesebrough-Pond's Usa Co., Division Of Conopco, Inc.Anti-tartar dental product and method
US7153493Jul 30, 2003Dec 26, 2006Warner-Lambert Company LlcClear oral compositions containing potassium salt
US7435409Mar 17, 2006Oct 14, 2008Mcneil-Ppc, Inc.Soluble potassium salt, a sodium (C8-C24) alkylsulfate, polar surfactant, water; free of visible potassium alkyl sulfate precipitates
US7729981Jan 12, 2007Jun 1, 2010Jpmorgan Chase Bank, N.A.On-line higher education financing system
US7814007Jan 12, 2007Oct 12, 2010Jpmorgan Chase Bank, N.A.On-line higher education financing system
US7835985Jan 12, 2007Nov 16, 2010Jpmorgan Chase Bank, N.A.On-line higher education financing system
US20070253918 *Mar 30, 2007Nov 1, 2007Den-Mat CorporationStable tooth whitening gel
CN1691934BOct 28, 2003Jan 9, 2013卡夫食品全球品牌有限责任公司Compositions for removing stains from dental surfaces and methods of making and using the same
WO2004039277A2 *Oct 28, 2003May 13, 2004Cadbury Adams Usa LlcCompositions for removing stains from dental surfaces
Classifications
U.S. Classification424/52, 424/49, 424/616, 424/53, 424/615, 424/613, 424/57, 424/614
International ClassificationA61K8/24, A61Q11/00
Cooperative ClassificationA61K8/24, A61Q11/00
European ClassificationA61Q11/00, A61K8/24
Legal Events
DateCodeEventDescription
Jul 1, 2008FPAYFee payment
Year of fee payment: 12
Jun 29, 2004FPAYFee payment
Year of fee payment: 8
Aug 4, 2000FPAYFee payment
Year of fee payment: 4
Nov 6, 1996ASAssignment
Owner name: COLGATE-PALMOLIVE COMPANY, NEW YORK
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:HSU, DONALD P.;KOHLI, RAJNISH;PRENCIPE, MICHAEL;REEL/FRAME:008211/0526;SIGNING DATES FROM 19941111 TO 19941114