Search Images Maps Play YouTube News Gmail Drive More »
Sign in
Screen reader users: click this link for accessible mode. Accessible mode has the same essential features but works better with your reader.

Patents

  1. Advanced Patent Search
Publication numberUS5700583 A
Publication typeGrant
Application numberUS 08/744,657
Publication dateDec 23, 1997
Filing dateNov 6, 1996
Priority dateMar 6, 1995
Fee statusPaid
Also published asEP0841361A1
Publication number08744657, 744657, US 5700583 A, US 5700583A, US-A-5700583, US5700583 A, US5700583A
InventorsDennis D. Jamiolkowski, Rao S. Bezwada
Original AssigneeEthicon, Inc.
Export CitationBiBTeX, EndNote, RefMan
External Links: USPTO, USPTO Assignment, Espacenet
Hydrogels of absorbable polyoxaesters containing amines or amido groups
US 5700583 A
Abstract
The present invention describes a crosslinked aliphatic polyoxaesters containing amines and/or amido groups and blends thereof with other polymers that may be used to produce surgical devices such as sutures, sutures with attached needles, molded devices, and the like. The crosslinked aliphatic polyoxaesters of the present invention is formed from an aliphatic polyoxaester having a first divalent repeating unit of formula I:
 O--C(O)--C(R1)(R2)--O--(R3)--O--C(R1)(R2)--C(O)--
!I
and a second repeating unit of the formula:
 --O--R12 --!U,                                  XVI
and optionally a third repeating unit with a formula selected from the group consisting of:
 --O--R4 --!A,                                   II
 --O--R5 --C(O)--!B,                             III
( --O--R5 --C(O)!P --O--)L G                XI
and combinations thereof wherein R12 contains an internal amine or internal amide group wherein the aliphatic polyoxaester has been crosslinked.
Images(18)
Previous page
Next page
Claims(67)
We claim:
1. A crosslinked aliphatic polyoxaester comprising a polyoxaester having a first divalent repeating unit of formula I:
 O--C(O)--C(R1)(R2)--O--(R3)--O--C(R1)(R2)--C(O)--!I
and a second repeating unit selected from the group of formulas consisting of:
 --O--R12 --!U,                                  XIV
wherein R1 and R2 are independently hydrogen or an alkyl group containing 1 to 8 carbon atoms; R3 is an alkylene unit or is an oxyalkylene group of the following formula:
-- (CH2)C --O--!D --(CH2)E --     IV
wherein C is an integer in the range of from 2 to about 5, D is an integer in the range of from about 0 to about 2,000, and E is an integer in the range of from about 2 to about 5, except when D is zero in which case E will be an integer from 2 to 12; R12 is an alkylene unit containing from 2 to 8 carbon atoms and containing an internal amine (--N(R10)--) or amide (--N(R11)--); R10 and R11 are independently hydrogen or an alkyl group containing 1 to 8 carbon atoms; and U is an integer in the range of from 1 to about 2,000; wherein the aliphatic polyoxaester has been crosslinked.
2. The crosslinked aliphatic polyoxaester of claim 1 wherein the aliphatic polyoxaester before crosslinking additionally contained a third repeating unit selected from the group consisting of:
 --O--R4 --!A,                                   II
 --O--R5 --C(O)--!B,                             III
( --O--R13 --C(O)!P --O--)L G and           XI
and combinations thereof; wherein R4 is an alkylene unit containing from 2 to 8 carbon atoms; A is an integer in the range of from 1 to about 2,000; R5 and R13 are independently selected from the group consisting of --C(R6)(R7)--, --(CH2)3 --O--, --CH2 --CH2 --O--CH2 --, --CR8 H--CH2 --, --(CH2)5 --, --(CH2)F --O--C(O)-- and --(CH2)K --C(O)--CH2 --; R6 and R7 are independently hydrogen or an alkyl containing from 1 to 8 carbon atoms; R8 is hydrogen or methyl; F and K are integers in the range of from 2 to 6; B is an integer in the range of from 1 to n such that the number average molecular weight of formula III is less than about 200,000; P is an integer in the range of from 1 to m such that the number average molecular weight of formula XI is less than about 1,000,000; G represents the residue minus from 1 to L hydrogen atoms from the hydroxyl groups of an alcohol previously containing from 1 to about 200 hydroxyl groups; and L is an integer from about 1 to about 200; wherein the polyoxaester has been crosslinked.
3. The crosslinked aliphatic polyoxaesters of claim 1 wherein aliphatic polyoxaester before crosslinking has the formula:
 --O--C(O)--C(R1)(R2)--O--(R3)--O--C(R1)(R2)C(O)--(O--R12)U --!N 
wherein N is an integer in the range of from about 1 to about 10,000.
4. The crosslinked aliphatic polyoxaester of claim 2 wherein the aliphatic polyoxaester before crosslinking has the formula:
 (--C(O)--C(R1)(R2)--O--R3 --O--C(R1)(R2)--C(O)--(O--R12)U --O)S (C(O)--R5 --O)B !W 
wherein S is an integer in the range of from about 1 to 10,000 and W is an integer in the range of from about 1 to about 1,000.
5. The crosslinked aliphatic polyoxaesters of claim 2 wherein the aliphatic polyoxaester before crosslinking has the formula:
 (--C(O)--C(R1)(R2)--O--R3 --O--C(R1)(R2)--C(O)--(O--R12)U --O)S ( --O--R13 C(O)!P --O--)L G!W 
wherein S is an integer in the range of from about 1 to 10,000 and W is an integer in the range of from about 1 to about 1,000.
6. A device made from a crosslinked aliphatic polyoxaester comprising an aliphatic polyoxaester, a first divalent repeating unit of formula I:
 O--C(O)--C(R1)(R2)--O--(R3)--O--C(R1)(R2)--C(O)--!I
and a second repeating unit selected from the group of formulas consisting of:
 --O--R12 --!U,                                  XIV
wherein R1 and R2 are independently hydrogen or an alkyl group containing 1 to 8 carbon atoms; R3 is an alkylene unit or is an oxyalkylene group of the following formula:
-- (CH2)C --O--!D --(CH2)E --     IV
wherein C is an integer in the range of from 2 to about 5, D is an integer in the range of from about 0 to about 2,000, and E is an integer in the range of from about 2 to about 5, except when D is zero in which case E will be an integer from 2 to 12; R12 is an alkylene unit containing from 2 to 8 carbon atoms and containing an internal amine (--N(R10)--) or amide (--N(R11)--); R10 and R11 are independently hydrogen or an alkyl group containing 1 to 8 carbon atoms; and U is an integer in the range of from 1 to about 2,000; wherein the aliphatic polyoxaester has been crosslinked.
7. The device of claim 6 wherein the aliphatic polyoxaester before crosslinking additionally contained a third repeating unit selected from the group consisting of:
 --O--R4 --!A,                                   II
 --O--R5 --C(O)--!B,                             III
( --O--R13 --C(O)!P --O--)L G and           XI
combinations thereof; wherein R4 is an alkylene unit containing from 2 to 8 carbon atoms; A is an integer in the range of from 1 to about 2,000; R5 and R13 are independently selected from the group consisting of --C(R6)(R7)--, --(CH2)3 --O--, --CH2 --CH2 --O--CH2 --, --CR8 H--CH2 --, --(CH2)5 --, --(CH2)F --O--C(O)-- and --(CH2)K --C(O)--CH2 --; R6 and R7 are independently hydrogen or an alkyl containing from 1 to 8 carbon atoms; R6 is hydrogen or methyl; F and K are integers in the range of from 2 to 6; B is an integer in the range of from 1 to n such that the number average molecular weight of formula III is less than about 200,000; P is an integer in the range of from 1 to m such that the number average molecular weight of formula XI is less than about 1,000,000; G represents the residue minus from 1 to L hydrogen atoms from the hydroxyl groups of an alcohol previously containing from 1 to about 200 hydroxyl groups; and L is an integer from about 1 to about 200.
8. The device of claim 6 wherein the device is an absorbable surgical device.
9. The device of claim 6 wherein the absorbable surgical device is selected from the group consisting of burn dressings, hernia patches, medicated dressings, fascial substitutes, gauze, fabrics, sheets, felts, sponges, gauze bandages, arterial graft, bandages for skin surfaces, suture knot clip, pins, clamps, screws, plates, clips, staples, hooks, buttons, snaps, bone substitutes, intrauterine devices, tubes, surgical instruments, vascular implants, vascular supports, vertebral discs, and artificial skin.
10. The device of claim 6 wherein the device is a filament.
11. The device of claim 10 wherein the filament is attached to a needle.
12. The device of claim 6 wherein the aliphatic polyoxaester before crosslinking has the formula:
 --O--C(O)--C(R1)(R2)--O--(R3)--O--C(R1)(R2)--C(O)--(O--R12)U --!N 
wherein N is an integer in the range of from about 1 to about 10,000.
13. The device of claim 6 wherein the aliphatic polyoxaester before crosslinking has the formula:
 (--C(O)--C(R1)(R2)--O--R3 --O--C(R1)(R2)--C(O)--(O--R12)U --O)S (C(O)--R5 --O)B !W 
wherein S is an integer in the range of from about 1 to 10,000 and W is an integer in the range of from about 1 to about 1,000.
14. The device of claim 6 wherein the aliphatic polyoxaester before crosslinking has the formula:
 (--C(O)--C(R1)(R2)--O--(R3)--O--C(R1)(R2)--C(O)--(O--R12)U --O)S ( --O--R13 --C(O)!P --O--)L G!W 
wherein S is an integer in the range of from about 1 to 10,000 and W is an integer in the range of from about 1 to about 1,000.
15. A coated device comprising an aliphatic polyoxaesters having a first divalent repeating unit of formula I:
 O--C(O)--C(R1)(R2)--O--(R3)--O--C(R1)(R2)--C(O)--!I
and a second repeating unit of formula:
 --O--R12 --!U,                                  XIV
and combinations thereof, wherein R1 and R2 are independently hydrogen or an alkyl group containing 1 to 8 carbon atoms; R3 is an alkylene unit or is an oxyalkylene group of the following formula:
-- (CH2)C --O--!D --(CH2)E --     IV
wherein C is an integer in the range of from 2 to about 5, D is an integer in the range of from about 0 to about 2,000, and E is an integer in the range of from about 2 to about 5, except when D is zero in which case E will be an integer from 2 to 12; R12 is an alkylene unit containing from 2 to 8 carbon atoms and containing an internal amine (--N(R10)--) or amide (--N(R11)--); R10 and R11 are independently hydrogen or an alkyl group containing 1 to 8 carbon atoms; and U is an integer in the range of from 1 to about 2,000; wherein the aliphatic polyoxaester has been crosslinked.
16. The coated device of claim 15 wherein the aliphatic polyoxaester additionally contains a third repeating unit selected from the group consisting of:
 --O--R4 --!A,                                   II
 --O--R5 --C(O)--!B,                             III
( --O--R13 --C(O)!P --O--)L G and           XI
combinations thereof wherein R4 is an alkylene unit containing from 2 to 8 carbon atoms; A is an integer in the range of from 1 to about 2,000; R5 and R13 are independently selected from the group consisting of --C(R6)(R7)--, --(CH2)3 --O--, --CH2 --CH2 --O--CH2 --, --CR8 H--CH2 --, --(CH2)5 --, --(CH2)F --O--C(O)-- and --(CH2)K --C(O)--CH2 --; R6 and R7 are independently hydrogen or an alkyl containing from 1 to 8 carbon atoms; R8 is hydrogen or methyl; F and K are integers in the range of from 2 to 6; B is an integer in the range of from 1 to n such that the number average molecular weight of formula III is less than about 200,000; P is an integer in the range of from 1 to m such that the number average molecular weight of formula XI is less than about 1,000,000; G represents the residue minus from 1 to L hydrogen atoms from the hydroxyl groups of an alcohol previously containing from 1 to about 200 hydroxyl groups; and L is an integer from about 1 to about 200.
17. The coated device of claim 15 wherein the device is a suture.
18. The coated device of claim 17 wherein the suture is attached to a needle.
19. The coated device of claim 15 wherein the aliphatic polyoxaesters have the formula:
 --O--C(O)--C(R1)(R2)--O--(R3)--O--C(R1)(R2)--C(O)--(O--R12)U --!N 
wherein N is an integer in the range of from about 1 to about 10,000.
20. The coated device of claim 15 wherein the aliphatic polyoxaesters have the formula:
 (--C(O)--C(R1)(R2)--O--R3 --O--C(R1)(R2)--C(O)--(O--R12)U --O)S (C(O)--R5 --O)B !W 
wherein S is an integer in the range of from about 1 to 10,000 and W is an integer in the range of from about 1 to about 1,000.
21. The coated device of claim 15 wherein the aliphatic polyoxaesters have the formula:
 (--C(O)--C(R1)(R2)--O--R3 --O--C(R1)(R2)--C(O)--(O--R12)U --O)S ( --O--R13 --C(O)!P --O--)L G!W 
wherein S is an integer in the range of from about 1 to 10,000 and W is integer in the range of from about 1 to about 1,000.
22. A drug delivery matrix comprising a drug and a crosslinked aliphatic polyoxaester wherein the crosslinked aliphatic polyoxaester is formed from an aliphatic polyoxaester has a first divalent repeating unit of formula I:
 O--C(O)--C(R1)(R2)--O--(R3)--O--C(R1)(R2)--C(O)--!I
and a second repeating unit of formula:
 --O--R12 --!U,                                  XIV
wherein R1 and R2 are independently hydrogen or an alkyl group containing 1 to 8 carbon atoms; R3 is an alkylene unit or is an oxyalkylene group of the following formula:
-- (CH2)C --O--!D --(CH2)E --     IV
wherein C is an integer in the range of from 2 to about 5, D is an integer in the range of from about 0 to about 2,000, and E is an integer in the range of from about 2 to about 5, except when D is zero in which case E will be an integer from 2 to 12; R12 is an alkylene unit containing from 2 to 8 carbon atoms and containing an internal amine (--N(R10)--) or amide (--N(R11)--); R10 and R11 are independently hydrogen or an alkyl group containing 1 to 8 carbon atoms; and U is an integer in the range of from 1 to about 2,000.
23. The drug delivery matrix of claim 22 wherein the aliphatic polyoxaester additionally contains a third repeating unit selected from the group consisting of:
 --O--R4 --!A,                                   II
 --O--R5 --C(O)--!B,                             III
( --O--R13 --C(O)!P --O--)L G and           XI
combinations thereof; wherein R4 is an alkylene unit containing from 2 to 8 carbon atoms; A is an integer in the range of from 1 to about 2,000; R5 and R13 are independently selected from the group consisting of --C(R6)(R7)--, --(CH2)3 --O--, --CH2 --CH2 --O--CH2 --, --CR8 H--CH2 --, --(CH2)5 --, --(CH2)F --O--C(O)-- and --(CH2)K --C(O)--CH2 --; R6 and R7 are independently hydrogen or an alkyl containing from 1 to 8 carbon atoms; R8 is hydrogen or methyl; F and K are integers in the range of from 2 to 6; B is an integer in the range of from 1 to n such that the number average molecular weight of formula III is less than about 200,000; P is an integer in the range of from 1 to m such that the number average molecular weight of formula XI is less than about 1,000,000; G represents the residue minus from 1 to L hydrogen atoms from the hydroxyl groups of an alcohol previously containing from 1 to about 200 hydroxyl groups; and L is an integer from about 1 to about 200.
24. The drug delivery matrix of claim 22 wherein the aliphatic polyoxaester before crosslinking has the formula:
 (--C(O)--C(R1)(R2)--O--R3 --O--C(R1)(R2)--C(O)--(O--R12)U --O)S (C(O)--R5 --O)B !W 
wherein S is an integer in the range of from about 1 to 10,000 and W is an integer in the range of from about 1 to about 1,000.
25. The drug delivery matrix of claim 22 wherein the aliphatic polyoxaester before crosslinking has the formula:
 (--C(O)--C(R1)(R2)--O--R3 --O--C(R1)(R2)--C(O)--(O--R12)U --O)S ( --O--R13 --C(O)!P --O--)L G!W 
wherein S is an integer in the range of from about 1 to 10,000 and W is an integer in the range of from about 1 to about 1,000.
26. A crosslinked aliphatic polyoxaester comprising an aliphatic polyoxaester having a first divalent repeating unit of formula I:
 O--C(O)--C(R1)(R2)--O--(R3)--O--C(R1)(R2)--C(O)--!I
and two second repeating unit of the formulas:
 --O--R5 --C(O)--!B, and                         III
( --O--R13 --C(O)!P --O--)L G               XI
wherein R1 and R2 are independently hydrogen or an alkyl group containing 1 to 8 carbon atoms; R3 is an alkylene unit or is an oxyalkylene group of the following formula:
-- (CH2)C --O--!D --(CH2)E --     IV
wherein C is an integer in the range of from 2 to about 5, D is an integer in the range of from about 0 to about 2,000, and E is an integer in the range of from about 2 to about 5, except when D is zero, in which case E will be from 2 to 12; R5 and R13 are different and are selected from the group consisting of --C(R6)(R7)--, --(CH2)3 --O--,--CH2 --CH2 --O--CH2 --, --CR8 H--CH2 --, --(CH2)5 --, --(CH2)F --O--C(O)-- and --(CH2)K --C(O)--CH2 --; R6 and R7 are independently hydrogen or an alkyl containing from 1 to 8 carbon atoms; R8 is hydrogen or methyl; F and K are integers in the range of from 2 to 6; B is an integer in the range of from 1 to n such that the number average molecular weight of formula III is less than about 200,000; P is an integer in the range of from 1 to m such that the number average molecular weight of formula XI is less than about 1,000,000; G represents the residue minus from 1 to L hydrogen atoms from the hydroxyl groups of an alcohol previously containing from 1 to about 200 hydroxyl groups; and L is an integer from about 1 to about 200; wherein the aliphatic polyoxaester has been crosslinked.
27. The crosslinked aliphatic polyoxaester of claim 26 wherein the aliphatic polyoxaester has additionally a third repeating unit of the formula:
 --O--R4 --!A,                                   II
wherein R4 is an alkylene unit containing from 2 to 8 carbon atoms; A is an integer in the range of from 1 to 1,000.
28. A device made from a crosslinked aliphatic polyoxaesters comprising an aliphatic polyoxaester that has a first divalent repeating unit of formula I:
 O--C(O)--C(R1)(R2)--O--(R3)--O--C(R1)(R2)--C(O)--!I
and two second repeating unit selected from the group of formulas consisting of:
 --O--R5 --C(O)--!B,                             III
( --O--R13 --C(O)!P --O--)L G               XI
wherein R1 and R2 are independently hydrogen or an alkyl group containing 1 to 8 carbon atoms; R3 is an alkylene unit or is an oxyalkylene group of the following formula:
-- (CH2)C --O--!D --(CH2)E --     IV
wherein C. is an integer in the range of from 2 to about 5, D is an integer in the range of from about 0 to about 2,000, and E is an integer in the range of from about 2 to about 5, except when D is zero, in which case E will be from 2 to 12; R5 and R13 are different and are selected from the group consisting of --C(R6)(R7)--, --(CH2)3 --O--, --CH2 --CH2 --O--CH2 --, --CR8 H--CH2 --, --(CH2)5 --, --(CH2)F --O--C(O)-- and --(CH2)K --C(O)--CH2 --; R6 and R7 are independently hydrogen or an alkyl containing from 1 to 8 carbon atoms; R8 is hydrogen or methyl; F and K are integers in the range of from 2 to 6; B is an integer in the range of from 1 to n such that the number average molecular weight of formula III is less than about 200,000; P is an integer in the range of from 1 to m such that the number average molecular weight of formula XI is less than about 1,000,000; G represents the residue minus from 1 to L hydrogen atoms from the hydroxyl groups of an alcohol previously containing from 1 to about 200 hydroxyl groups; and L is an integer from about 1 to about 200; wherein the aliphatic polyoxaester has been crosslinked.
29. The crosslinked aliphatic polyoxaester of claim 26 wherein the aliphatic polyoxaester has additionally present a third repeating unit of the formula:
 --O--R4 --!A,                                   II
wherein R4 is an alkylene unit containing from 2 to 8 carbon atoms; A is an integer in the range of from 1 to 1,000.
30. A coated device comprising a device coated with a crosslinked aliphatic polyoxaester is formed from an aliphatic polyoxaesters having a first divalent repeating unit of formula I:
 O--C(O)--C(R1)(R2)--O--(R3)--O--C(R1)(R2)--C(O)--!I
and two second repeating unit of the formulas:
 --O--R5 --C(O)--!B,                             III
( --O--R13 --C(O)!P --O--)L G               XI
wherein R1 and R2 are independently hydrogen or an alkyl group containing 1 to 8 carbon atoms; R3 is an alkylene unit or is an oxyalkylene group of the following formula:
-- (CH2)C --O--!D --(CH2)E --     IV
wherein C is an integer in the range of from 2 to about 5, D is an integer in the range of from about 0 to about 2,000, and E is an integer in the range of from about 2 to about 5, except when D is zero, in which case E will be from 2 to 12; R5 and R13 are different and are selected from the group consisting of --C(R6)(R7)--, --(CH2)3 --O--, --CH2 --CH2 --O--CH2 --, --CR8 H--CH2 --, --(CH2)5 --, --(CH2)F --O--C(O)-- and --(CH2)K --C(O)--CH2 --; R6 and R7 are independently hydrogen or an alkyl containing from 1 to 8 carbon atoms; R8 is hydrogen or methyl; F and K are integers in the range of from 2 to 6; B is an integer in the range of from 1 to n such that the number average molecular weight of formula III is less than about 200,000; P is an integer in the range of from 1 to m such that the number average molecular weight of formula XI is less than about 1,000,000; G represents the residue minus from 1 to L hydrogen atoms from the hydroxyl groups of an alcohol previously containing from 1 to about 200 hydroxyl groups; and L is an integer from about 1 to about 200; wherein the polyoxaester has been crosslinked.
31. The crosslinked aliphatic polyoxaester of claim 30 wherein the aliphatic polyoxaester has additionally present a third repeating unit of the formula:
 --O--R4 --!A,                                   II
wherein R4 is an alkylene unit containing from 2 to 8 carbon atoms; A is an integer in the range of from 1 to 1,000.
32. A drug delivery matrix comprising a drug and a crosslinked aliphatic polyoxaester wherein the crosslinked aliphatic polyoxaester is formed from an aliphatic polyoxaester having a first divalent repeating unit of formula I:
 --O--C(O)--C(R1)(R2)--O--(R3)--O--C(R1)(R2)--C(O)--!                                                        I
and two second repeating unit of the formulas:
 --O--R5 --C(O)--!B,                             III
( --O--R13 --C(O)!P --O--)L G               XI
wherein R1 and R2 are independently hydrogen or an alkyl group containing 1 to 8 carbon atoms; R3 is an alkylene unit or is an oxyalkylene group of the following formula:
-- (CH2)C --O--!D --(CH2)E --     IV
wherein C is an integer in the range of from 2 to about 5, D is an integer in the range of from about 0 to about 2,000, and E is an integer in the range of from about 2 to about 5, except when D is zero, in which case E will be from 2 to 12; R5 and R13 are different and are selected from the group consisting of --C(R6)(R7)--, --(CH2)3 --O--, --CH2 --CH2 --O--CH2 --, --CR8 H--CH2 --, --(CH2)5 --, --(CH2)F --O--C(O)-- and --(CH2)K --C(O)--CH2 --; R6 and R7 are independently hydrogen or an alkyl containing from 1 to 8 carbon atoms; R8 is hydrogen or methyl; F and K are integers in the range of from 2 to 6; B is an integer in the range of from 1 to n such that the number average molecular weight of formula III is less than about 200,000; P is an integer in the range of from 1 to m such that the number average molecular weight of formula XI is less than about 1,000,000; G represents the residue minus from 1 to L hydrogen atoms from the hydroxyl groups of an alcohol previously containing from 1 to about 200 hydroxyl groups; and L is an integer from about 1 to about 200; wherein the polyoxaester has been crosslinked before or after the addition of the drug.
33. The drug delivery matrix of claim 32 wherein the aliphatic polyoxaester has additionally present a third repeating unit of the formula:
 --O--R4 --!A,                                   II
wherein R4 is an alkylene unit containing from 2 to 8 carbon atoms; A is an integer in the range of from 1 to 1,000.
34. A polymer blend comprising a crosslinked aliphatic polyoxaesters formed from an aliphatic polyoxaester having a first divalent repeating unit of formula I:
 --O--C(O)--C(R1)(R2)--O--(R3)--O--C(R1)(R2)--C(O)--!                                                        I
and a second repeating unit selected from the group of formulas consisting of:
 --O--R12 --!U,                                  XIV
wherein R1 and R2 are independently hydrogen or an alkyl group containing 1 to 8 carbon atoms; R3 is an alkylene unit or is an oxyalkylene group of the following formula:
-- (CH2)C --O--!D --(CH2)E --     IV
wherein C is an integer in the range of from 2 to about 5, D is an integer in the range of from about 0 to about 2,000, and E is an integer in the range of from about 2 to about 5, except when D is zero in which case E will be an integer from 2 to 12; R12 is an alkylene unit containing from 2 to 8 carbon atoms and containing an internal amine (--N(R10)--) or amide (--N(R11)--); R10 and R11 are independently hydrogen or an alkyl group containing 1 to 8 carbon atoms; and U is an integer in the range of from 1 to about 2,000; and which has been crosslinked,
a second polymer selected from the group consisting of homopolymer and copolymer of lactone type polymers with the repeating units described by formulas III and XI, aliphatic polyurethanes, polyether polyurethanes, polyester polyurethanes, polyethylene copolymers, polyamides, polyvinyl alcohols, poly(ethylene oxide), polypropylene oxide, polyethylene glycol, polypropylene glycol, polytetramethylene oxide, polyvinyl pyrrolidone, polyacrylamide, poly(hydroxy ethyl acrylate), poly(hydroxyethyl methacrylate), absorbable polyoxalates, absorbable polyanhydrides and combinations thereof.
35. The polymer blend of claim 34 wherein the aliphatic polyoxaester additionally contains a third repeating unit selected from the group consisting of:
 --O--R4 --!A,                                   II
 --O--R5 --C(O)--!B,                             III
( --O--R13 --C(O)!P --O--)L G and           XI
and combinations thereof; wherein R4 is an alkylene unit containing from 2 to 8 carbon atoms; A is an integer in the range of from 1 to about 2,000; R5 and R13 are independently selected from the group consisting of --C(R6)(R7)--, --(CH2)3 --, --CH2 --CH2 --O--CH2 --, --CR8 H--CH2 --, --(CH2)5 --, --(CH2)F --O--C(O)-- and --(CH2)K --C(O)--CH2 --; R6 and R7 are independently hydrogen or an alkyl containing from 1 to 8 carbon atoms; R8 is hydrogen or methyl; F and K are integers in the range of from 2 to 6; B is an integer in the range of from 1 to n such that the number average molecular weight of formula III is less than about 200,000; P is an integer in the range of from 1 to m such that the number average molecular weight of formula XI is less than about 1,000,000; G represents the residue minus from 1 to L hydrogen atoms from the hydroxyl groups of an alcohol previously containing from 1 to about 200 hydroxyl groups; and L is an integer from about 1 to about 200.
36. The polymer blend of claim 34 wherein the aliphatic polyoxaester before crosslinking has the formula:
 --O--C(O)--C(R1)(R2)--O--(R3)--O--C(R1)(R2)C(O)--(O--R12)U --!N 
wherein N is an integer in the range of from about 1 to about 10,000.
37. The polymer blend of claim 35 wherein the aliphatic polyoxaester has the formula:
 (--C(O)--C(R1)(R2)--O--R3 --O--C(R1)(R2)--C(O)--(O--R12)U --O)S (C(O)--R5 --O)B !W 
wherein S is an integer in the range of from about 1 to 10,000 and W is an integer in the range of from about 1 to about 1,000.
38. The polymer blend of claim 35 wherein the aliphatic polyoxaesters has the formula:
 (--C(O)--C(R1)(R2)--O--R3 --O--C(R1)(R2)--C(O)--(O--R12)U --O)S ( --O--R13 --C(O)!P --O--)L G!W 
wherein S is an integer in the range of from about 1 to 10,000 and W is an integer in the range of from about 1 to about 1,000.
39. A device made from a polymer blend comprising a crosslinked aliphatic polyoxaesters formed from an aliphatic polyoxaester having a first divalent repeating unit of formula I:
 --O--C(O)--C(R1)(R2)--O--(R3)--O--C(R1)(R2)--C(O)--!                                                        I
and a second repeating unit selected from the group of formulas consisting of:
 --O--R12 --!U,                                  XIV
wherein R1 and R2 are independently hydrogen or an alkyl group containing 1 to 8 carbon atoms; R3 is an alkylene unit or is an oxyalkylene group of the following formula:
-- (CH2)C --O--!D --(CH2)E --     IV
wherein C is an integer in the range of from 2 to about 5, D is an integer in the range of from about 0 to about 2,000, and E is an integer in the range of from about 2 to about 5, except when D is zero in which case E will be an integer from 2 to 12; R12 is an alkylene unit containing from 2 to 8 carbon atoms and containing an internal amine (--N(R10)--) or amide (--N(R11)--); R10 and R11 are independently hydrogen or an alkyl group containing 1 to 8 carbon atoms; and U is an integer in the range of from 1 to about 2,000; wherein the aliphatic polyoxaester has been crosslinked and
a second polymer selected from the group consisting of homopolymer and copolymer of lactone type polymers with the repeating units described by formulas III and XI, aliphatic polyurethanes, polyether polyurethanes, polyester polyurethanes, polyethylene copolymers, polyamides, polyvinyl alcohols, poly(ethylene oxide), polypropylene oxide, polyethylene glycol, polypropylene glycol, polytetramethylene oxide, polyvinyl pyrrolidone, polyacrylamide, poly(hydroxy ethyl acrylate), poly(hydroxyethyl methacrylate), absorbable polyoxalates, absorbable polyanhydrides and combinations thereof.
40. The device of claim 39 wherein the aliphatic polyoxaester additionally contains a third repeating unit selected from the group consisting of:
 --O--R4 --!A,                                   II
 --O--R5 --C(O)--!B,                             III
( --O--R13 --C(O)!P --O--)L G and           XI
combinations thereof; wherein R4 is an alkylene unit containing from 2 to 8 carbon atoms; A is an integer in the range of from 1 to about 2,000; R5 and R13 are independently selected from the group consisting of --C(R6)(R7)--, --(CH2)3 --O--, --CH2 --CH2 --O--CH2 --, --CR8 H--CH2 --, --(CH2)5 --, --(CH2)F --O--C(O)-- and --(CH2)K --C(O)--CH2 --; R6 and R7 are independently hydrogen or an alkyl containing from 1 to 8 carbon atoms; R8 is hydrogen or methyl; F and K are integers in the range of from 2 to 6; B is an integer in the range of from 1 to n such that the number average molecular weight of formula III is less than about 200,000; P is an integer in the range of from 1 to m such that the number average molecular weight of formula XI is less than about 1,000,000; G represents the residue minus from 1 to L hydrogen atoms from the hydroxyl groups of an alcohol previously containing from 1 to about 200 hydroxyl groups; and L is an integer from about 1 to about 200.
41. The device of claim 39 wherein the device is surgical device.
42. The surgical device of claim 39 wherein the absorbable surgical device is selected from the group consisting of burn dressings, hernia patches, medicated dressings, fascial substitutes, gauze, fabrics, sheets, felts, sponges, gauze bandages, arterial graft, bandages for skin surfaces, suture knot clip, pins, clamps, screws, plates, clips, staples, hooks, buttons, snaps, bone substitutes, intrauterine devices, tubes, surgical instruments, vascular implants, vascular supports, vertebral discs, and artificial skin.
43. The surgical device of claim 39 wherein the device is a filament.
44. The device of claim 43 wherein the filament is attached to a needle.
45. The device of claim 39 wherein the aliphatic polyoxaester has the formula:
 --O--C(O)--C(R1)(R2)--O--(R3)--O--C(R1)(R2)--C(O)--(O--R12)U --!N 
wherein N is an integer in the range of from about 1 to about 10,000.
46. The device of claim 39 wherein the aliphatic polyoxaester has the formula:
 (--C(O)--C(R1)(R2)--O--R3 --O--C(R1)(R2)--C(O)--(O--R12)U --O)S (C(O)--R5 --O)B !W 
wherein S is an integer in the range of from about 1 to 10,000 and W is an integer in the range of from about 1 to about 1,000.
47. The device of claim 39 wherein the aliphatic polyoxaester has the formula:
 (--C(O)--C(R1)(R2)--O--(R3)--O--C(R1) (R2)--C(O)--(O--R12)U --O)S ( --O--R13 13 C(O)!P --O--)L G!W 
wherein S is an integer in the range of from about 1 to 10,000 and W is an integer in the range of from about 1 to about 1,000.
48. A coated device comprising a device coated with a polymer blend of a crosslinked aliphatic polyoxaesters composed of an aliphatic polyoxaester having a first divalent repeating unit of formula I:
 O--C(O)--C(R1)(R2)--O--(R3)--O--C(R1)(R2)--C(O)--!I
and a second repeating unit of formula:
 --O--R12 --!U,                                  XIV
and combinations thereof, wherein R1 and R2 are independently hydrogen or an alkyl group containing 1 to 8 carbon atoms; R3 is an alkylene unit or is an oxyalkylene group of the following formula:
-- (CH2)C --O--!D --(CH2)E --     IV
wherein C is an integer in the range of from 2 to about 5, D is an integer in the range of from about 0 to about 2,000, and E is an integer in the range of from about 2 to about 5, except when D is zero in which case E will be an integer from 2 to 12; R12 is an alkylene unit containing from 2 to 8 carbon atoms and containing an internal amine (--N(R10)--) or amide (--N(R11)--); R10 and R11 are independently hydrogen or an alkyl group containing 1 to 8 carbon atoms; and U is an integer in the range of from 1 to about 2,000; wherein the aliphatic polyoxaester has been crosslinked; and
a second polymer selected from the group consisting of homopolymer and copolymer of lactone type polymers with the repeating units described by formulas III and XI, aliphatic polyurethanes, polyether polyurethanes, polyester polyurethanes, polyethylene copolymers, polyamides, polyvinyl alcohols, poly(ethylene oxide), polypropylene oxide, polyethylene glycol, polypropylene glycol, polytetramethylene oxide, polyvinyl pyrrolidone, polyacrylamide, poly(hydroxy ethyl acrylate), poly(hydroxyethyl methacrylate), absorbable polyoxalates, absorbable polyanhydrides and combinations thereof.
49. The coated device of claim 48 wherein the aliphatic polyoxaester additionally contains a third repeating unit selected from the group consisting of:
 --O--R4 --!A,                                   II
 --O--R5 --C(O)--!B,                             III
( --O--R13 --C(O)!P --O--)L G and           XI
combinations thereof wherein R4 is an alkylene unit containing from 2 to 8 carbon atoms; A is an integer in the range of from 1 to about 2,000; R5 and R13 are independently selected from the group consisting of --C(R6)(R7)--, --(CH2)3 --O--, CH2 --CH2 --O--CH2 --, --CR8 H--CH2 --, --(CH2)5 --, --(CH2)F --O--C(O)-- and --(CH2)K --C(O)--CH2 --; R6 and R7 are independently hydrogen or an alkyl containing from 1 to 8 carbon atoms; R8 is hydrogen or methyl; F and K are integers in the range of from 2 to 6; B is an integer in the range of from 1 to n such that the number average molecular weight of formula III is less than about 200,000; P is an integer in the range of from 1 to m such that the number average molecular weight of formula XI is less than about 1,000,000; G represents the residue minus from 1 to L hydrogen atoms from the hydroxyl groups of an alcohol previously containing from 1 to about 200 hydroxyl groups; and L is an integer from about 1 to about 200.
50. The coated device of claim 48 wherein the device is a suture.
51. The coated device of claim 50 wherein the device is attached to a needle.
52. The coated device of claim 48 wherein the aliphatic polyoxaester has the formula:
 --O--C(O)--C(R1)(R2)--O--(R3)--O--C(R1)(R2)--C(O)--(O--R12)U --!N 
wherein N is an integer in the range of from about 1 to about 10,000.
53. The coated device of claim 48 wherein the aliphatic polyoxaester has the formula:
 (--C(O)--C(R1)(R2)--O--R3 --O--C (R1)(R2)--C(O)--(O--R12)U --O)S (C(O)--R5 --O)B !W 
wherein S is an integer in the range of from about 1 to 10,000 and W is an integer in the range of from about 1 to about 1,000.
54. The coated device of claim 48 wherein the aliphatic polyoxaester has the formula:
 (--C(O)--C(R1)(R2)--O--R3 --O--C(R1)(R2)--C(O)--(O--R12)U --O)S ( --O--R13 --C(O)!P --O--)L G!W 
wherein S is an integer in the range of from about 1 to 10,000 and W is an integer in the range of from about 1 to about 1,000.
55. A drug delivery matrix comprising a drug and a polymer blend composed of a crosslinked aliphatic polyoxaester having a first divalent repeating unit of formula I formed from an aliphatic polyoxaester:
 O--C(O)--C(R1)(R2)--O--(R3)--O--C(R1)(R2)--C(O)--!I
and a second repeating unit of formula:
 --O--R12 --!U,                                  XIV
wherein R1 and R2 are independently hydrogen or an alkyl group containing 1 to 8 carbon atoms; R3 is an alkylene unit or is an oxyalkylene group of the following formula:
-- (CH2)C --O--!D --(CH2)E --     IV
wherein C is an integer in the range of from 2 to about 5, D is an integer in the range of from about 0 to about 2,000, and E is an integer in the range of from about 2 to about 5, except when D is zero in which case E will be an integer from 2 to 12; R12 is an alkylene unit containing from 2 to 8 carbon atoms and containing an internal amine (--N(R10)--) or amide (--N(R11)--); R10 and R11 are independently hydrogen or an alkyl group containing 1 to 8 carbon atoms; and U is an integer in the range of from 1 to about 2,000; wherein the aliphatic polyoxaester has been crosslinked; and
a second polymer selected from the group consisting of homopolymer and copolymer of lactone type polymers with the repeating units described by formulas III and XI, aliphatic polyurethanes, polyether polyurethanes, polyester polyurethanes, polyethylene copolymers, polyamides, polyvinyl alcohols, poly(ethylene oxide), polypropylene oxide, polyethylene glycol, polypropylene glycol, polytetramethylene oxide, polyvinyl pyrrolidone, polyacrylamide, poly(hydroxy ethyl acrylate), poly(hydroxyethyl methacrylate), absorbable polyoxalates, absorbable polyanhydrides and combinations thereof.
56. The drug delivery matrix of claim 55 wherein the aliphatic polyoxaester additionally contains a third repeating unit selected from the group consisting of:
 --O--R4 --!A,                                   II
 --O--R5 --C(O)--!B,                             III
( --O--R13 --C(O)!P --O--)L G and           XI
combinations thereof; wherein R4 is an alkylene unit containing from 2 to 8 carbon atoms; A is an integer in the range of from 1 to about 2,000; R5 and R13 are independently selected from the group consisting of --C(R6)(R7)--, --(CH2)3 --O--, --CH2 --CH2 --O--CH2 --, --CR8 H--CH2 --, --(CH2)5 --, --(CH2)F --O--C(O)-- and --(CH2)K --C(O)--CH2 --; R6 and R7 are independently hydrogen or an alkyl containing from 1 to 8 carbon atoms; R8 is hydrogen or methyl; F and K are integers in the range of from 2 to 6; B is an integer in the range of from 1 to n such that the number average molecular weight of formula III is less than about 200,000; P is an integer in the range of from 1 to m such that the number average molecular weight of formula XI is less than about 1,000,000; G represents the residue minus from 1 to L hydrogen atoms from the hydroxyl groups of an alcohol previously containing from 1 to about 200 hydroxyl groups; and L is an integer from about 1 to about 200.
57. The drug delivery matrix of claim 55 wherein the aliphatic polyoxaester has the formula:
 (--C(O)--C(R1)(R2)--O--R3 --O--C(R1)(R2)--C(O)--(O--R12)U --O)S (C(O)--R5 --O)B !W 
wherein S is an integer in the range of from about 1 to 10,000 and W is an integer in the range of from about 1 to about 1,000.
58. The drug delivery matrix of claim 55 wherein the aliphatic polyoxaester has the formula:
 (--C(O)--C(R1)(R2)--O--R3 --O--C(R1)(R2)--C(O)--(O--R12)U --O)S ( --O--R13 --C(O)!P --O--)L G!W 
wherein S is an integer in the range of from about 1 to 10,000 and W is an integer in the range of from about 1 to about 1,000.
59. A polymer blend comprising a crosslinked aliphatic polyoxaesters formed from an aliphatic polyoxaester having a first divalent repeating unit of formula I:
 O--C(O)--C(R1)(R2)--O--(R3)--O--C(R1)(R2)--C(O)--!I
and two second repeating units of the formulas:
 --O--R5 --C(O)--!B, and                         III
( --O--R13 --C(O)!P --O--)L G               XI
wherein R1 and R2 are independently hydrogen or an alkyl group containing 1 to 8 carbon atoms; R3 is an alkylene unit or is an oxyalkylene group of the following formula:
-- (CH2)C --O--!D --(CH2)E --     IV
wherein C is an integer in the range of from 2 to about 5, D is an integer in the range of from about 0 to about 2,000, and E is an integer in the range of from about 2 to about 5, except when D is zero, in which case E will be from 2 to 12; R5 and R13 are different and are selected from the group consisting of --C(R6)(R7)--, --(CH2)3 --O--, --CH2 --CH2 --O--CH2 --, --CR8 H--CH2 --, --(CH2)5 --, --(CH2)F --O--C(O)-- and --(CH2)K --C(O)--CH2 --; R6 and R7 are independently hydrogen or an alkyl containing from 1 to 8 carbon atoms; R8 is hydrogen or methyl; F and K are integers in the range of from 2 to 6; B is an integer in the range of from 1 to n such that the number average molecular weight of formula III is less than about 200,000; P is an integer in the range of from 1 to m such that the number average molecular weight of formula XI is less than about 1,000,000; G represents the residue minus from 1 to L hydrogen atoms from the hydroxyl groups of an alcohol previously containing from 1 to about 200 hydroxyl groups; and L is an integer from about 1 to about 200; wherein the aliphatic polyoxaester has been crosslinked; and
a second polymer selected from the group consisting of homopolymer and copolymer of lactone type polymers with the repeating units described by formulas III and XI, aliphatic polyurethanes, polyether polyurethanes, polyester polyurethanes, polyethylene copolymers, polyamides, polyvinyl alcohols, poly(ethylene oxide), polypropylene oxide, polyethylene glycol, polypropylene glycol, polytetramethylene oxide, polyvinyl pyrrolidone, polyacrylamide, poly(hydroxy ethyl acrylate), poly(hydroxyethyl methacrylate), absorbable polyoxalates, absorbable polyanhydrides and combinations thereof.
60. The polymer blend of claim 59 wherein the aliphatic polyoxaester has additionally present a third repeating unit of the formula:
 --O--R4 --!A,                                   II
wherein R4 is an alkylene unit containing from 2 to 8 carbon atoms; A is an integer in the range of from 1 to 1,000.
61. A coated device comprising a device coated with a crosslinked aliphatic polyoxaester formed from an aliphatic polyoxaesters having a first divalent repeating unit of formula I:
 O--C(O)--C(R1)(R2)--O--(R3)--O--C(R1)(R2)--C(O)--!I
and two second repeating unit of the formulas:
 --O--R5 --C(O)--!B,                             III
( --O--R13 --C(O)!P --O--)L G               XI
wherein R1 and R2 are independently hydrogen or an alkyl group containing 1 to 8 carbon atoms; R3 is an alkylene unit or is an oxyalkylene group of the following formula:
-- (CH2)C --O--!D --(CH2)E --     IV
wherein C is an integer in the range of from 2 to about 5, D is an integer in the range of from about 0 to about 2,000, and E is an integer in the range of from about 2 to about 5, except when D is zero, in which case E will be from 2 to 12; R5 and R13 are different and are selected from the group consisting of --C(R6)(R7)--, --(CH2)3 --O--, --CH2 --CH2 --O--CH2 --, --CR8 H--CH2 --, --(CH2)5 --, --(CH2)F --O--C(O)-- and --(CH2)K --C(O)--CH2 --; R6 and R7 are independently hydrogen or an alkyl containing from 1 to 8 carbon atoms; R8 is hydrogen or methyl; F and K are integers in the range of from 2 to 6; B is an integer in the range of from 1 to n such that the number average molecular weight of formula III is less than about 200,000; P is an integer in the range of from 1 to m such that the number average molecular weight of formula XI is less than about 1,000,000; G represents the residue minus from 1 to L hydrogen atoms from the hydroxyl groups of an alcohol previously containing from 1 to about 200 hydroxyl groups; and L is an integer from about 1 to about 200; wherein the aliphatic polyoxaester is crosslinked and
a second polymer selected from the group consisting of homopolymer and copolymer of lactone type polymers with the repeating units described by formulas III and XI, aliphatic polyurethanes, polyether polyurethanes, polyester polyurethanes, polyethylene copolymers, polyamides, polyvinyl alcohols, poly(ethylene oxide), polypropylene oxide, polyethylene glycol, polypropylene glycol, polytetramethylene oxide, polyvinyl pyrrolidone, polyacrylamide, poly(hydroxy ethyl acrylate), poly(hydroxyethyl methacrylate), absorbable polyoxalates, absorbable polyanhydrides and combinations thereof.
62. The polymer blend of claim 30 wherein additionally present in the aliphatic polyoxaester is a third repeating unit of the formula:
 --O--R4 --!A,                                   II
wherein R4 is an alkylene unit containing from 2 to 8 carbon atoms; A is an integer in the range of from 1 to 1,000.
63. A drug delivery matrix comprising a drug and a polymer blend composed of a crosslinked aliphatic polyoxaester formed from an aliphatic polyoxaesters having a first divalent repeating unit of formula I:
 O--C(O)--C(R1)(R2)--O--(R3)--O--C(R1)(R2)--C(O)--!I
and two second repeating unit of the formulas:
 --O--R5 --C(O)--!B,                             III
( --O--R13 --C(O)!P --O--)L G               XI
wherein R1 and R2 are independently hydrogen or an alkyl group containing 1 to 8 carbon atoms; R3 is an alkylene unit or is an oxyalkylene group of the following formula:
-- (CH2)C --O--!D --(CH2)E --     IV
wherein C is an integer in the range of from 2 to about 5, D is an integer in the range of from about 0 to about 2,000, and E is an integer in the range of from about 2 to about 5, except when D is zero, in which case E will be from 2 to 12; R5 and R13 are different and are selected from the group consisting of --C(R6)(R7)--, --(CH2)3 --O--, --CH2 --CH2 --O--CH2 --, --CR8 H--CH2 --, --(CH2)5 --, --(CH2)F --O--C(O)-- and --(CH2)K --C(O)--CH2 --; R6 and R7 are independently hydrogen or an alkyl containing from 1 to 8 carbon atoms; R8 is hydrogen or methyl; F and K are integers in the range of from 2 to 6; B is an integer in the range of from 1 to n such that the number average molecular weight of formula III is less than about 200,000; P is an integer in the range of from 1 to m such that the number average molecular weight of formula XI is less than about 1,000,000; G represents the residue minus from 1 to L hydrogen atoms from the hydroxyl groups of an alcohol previously containing from 1 to about 200 hydroxyl groups; and L is an integer from about 1 to about 200; wherein the aliphatic polyoxaester is crosslinked; and
a second polymer selected from the group consisting of homopolymer and copolymer of lactone type polymers with the repeating units described by formulas III and XI, aliphatic polyurethanes, polyether polyurethanes, polyester polyurethanes, polyethylene copolymers, polyamides, polyvinyl alcohols, poly(ethylene oxide), polypropylene oxide, polyethylene glycol, polypropylene glycol, polytetramethylene oxide, polyvinyl pyrrolidone, polyacrylamide, poly(hydroxy ethyl acrylate), poly(hydroxyethyl methacrylate), absorbable polyoxalates, absorbable polyanhydrides and combinations thereof.
64. The drug delivery matrix of claim 63 wherein the aliphatic polyoxaester has additionally present a third repeating unit of the formula:
 --O--R4 --!A,                                   II
wherein R4 is an alkylene unit containing from 2 to 8 carbon atoms; A is an integer in the range of from 1 to 1,000.
65. A prepolymer comprising an aliphatic polyoxaester having a first divalent repeating unit of formula I:
 O--C(O)--C(R1)(R2)--O--(R3)--O--C(R1)(R2)--C(O)--!I
and a second repeating unit selected from the group of formulas consisting of:
 --O--R12 --!U,                                  XIV
wherein R1 and R2 are independently hydrogen or an alkyl group containing 1 to 8 carbon atoms; R3 is an alkylene unit or is an oxyalkylene group of the following formula:
-- (CH2)C --O--!D --(CH2)E --     IV
wherein C is an integer in the range of from 2 to about 5, D is an integer in the range of from about 0 to about 2,000, and E is an integer in the range of from about 2 to about 5, except when D is zero in which case E will be an integer from 2 to 12; R12 is an alkylene unit containing from 2 to 8 carbon atoms and containing an internal amine (--N(R10)--) or amide (--N(R11)--); R10 and R11 are independently hydrogen or an alkyl group containing 1 to 8 carbon atoms; and U is an integer in the range of from 1 to about 2,000; wherein the aliphatic polyoxaester is chemically linked to a polymerizable region.
66. A hydrogel comprising water and a crosslinked aliphatic polyoxaesters formed from an aliphatic polyoxaester having a first divalent repeating unit of formula I:
 O--C(O)--C(R1)(R2)--O--(R3)--O--C(R1)(R2)--C(O)--!I
and two second repeating unit of the formulas:
 --O--R5 --C(O)--!B, and                         III
( --O--R13 13 C(O)!P --O--)L G              XI
wherein R1 and R2 are independently hydrogen or an alkyl group containing 1 to 8 carbon atoms; R3 is an alkylene unit or is an oxyalkylene group of the following formula:
-- (CH2)C --O--!D --(CH2)E --     IV
wherein C is an integer in the range of from 2 to about 5, D is an integer in the range of from about 0 to about 2,000, and E is an integer in the range of from about 2 to about 5, except when D is zero, in which case E will be from 2 to 12; R5 and R13 are different and are selected from the group consisting of --C(R6)(R7)--, --(CH2)3 --O--, --CH2 --CH2 --O--CH2 --, --CR8 H--CH2 --, --(CH2)5 --, --(CH2)F --O--C(O)-- and --(CH2)K --C(O)--CH2 --; R6 and R7 are independently hydrogen or an alkyl containing from 1 to 8 carbon atoms; R8 is hydrogen or methyl; F and K are integers in the range of from 2 to 6; B is an integer in the range of from 1 to n such that the number average molecular weight of formula III is less than about 200,000; P is an integer in the range of from 1 to m such that the number average molecular weight of formula XI is less than about 1,000,000; G represents the residue minus from 1 to L hydrogen atoms from the hydroxyl groups of an alcohol previously containing from 1 to about 200 hydroxyl groups; and L is an integer from about 1 to about 200; wherein the polyoxaester has been crosslinked.
67. A hydrogel comprising water and a crosslinked aliphatic polyoxaester formed from a polyoxaester having a first divalent repeating unit of formula I:
 O--C(O)--C(R1)(R2)--O--(R3)--O--C(R1)(R2)--C(O)--!I
and a second repeating unit selected from the group of formulas consisting of:
 --O--R12 --!U,                                  XIV
wherein R1 and R2 are independently hydrogen or an alkyl group containing 1 to 8 carbon atoms; R3 is an alkylene unit or is an oxyalkylene group of the following formula:
-- (CH2)C --O--!D --(CH2)E --     IV
wherein C is an integer in the range of from 2 to about 5, D is an integer in the range of from about 0 to about 2,000, and E is an integer in the range of from about 2 to about 5, except when D is zero in which case E will be an integer from 2 to 12; R12 is an alkylene unit containing from 2 to 8 carbon atoms and containing an internal amine (--N(R10)--) or amide (--N(R11)--); R10 and R11 are independently hydrogen or an alkyl group containing 1 to 8 carbon atoms; and U is an integer in the range of from 1 to about 2,000.
Description
FIELD OF THE INVENTION

The present invention is a continuation-in-part of Ser. No. 08/611,529, filed Mar. 5, 1996, which is a continuation-in-part of Ser. No. 08/598,721 filed Feb. 8, 1996, now U.S. Pat. No. 5,595,751, which is a continuation-in-part of Ser. No. 08/554,011, filed Nov. 6, 1995 now abandoned, which is a continuation-in-part of Ser. No. 08/399,308, filed Mar. 6, 1995, now U.S. Pat. No. 5,464,929 (all hereby incorporated herein by reference) and relates to polyoxaesters containing amines and/or amido groups and blends thereof with other polymers and more particularly to surgical products made from polyoxaesters containing amines and/or amido groups and blends thereof with other polymers.

BACKGROUND OF THE INVENTION

Since Carothers early work in the 1920s and 1930s, aromatic polyester particularly poly(ethylene terephthalate) have become the most commercial important polyesters. The usefulness of these polymers is intimately linked to the stiffening action of the p-phenylene group in the polymer chain. The presence of the p-phenylene group in the backbone of the polymer chain leads to high melting points and good mechanical properties especially for fibers, films and some molded products. In fact poly(ethylene terephthalate) has become the polymer of choice for many common consumer products, such as one and two liter soft drink containers.

Several related polyester resins have been described in U.S. Pat. Nos. 4,440,922, 4,552,948 and 4,963,641 which seek to improve upon the properties of poly(ethylene terephthalate) by replacing terephthalic acid with other related dicarboxylic acids which contain phenylene groups. These polymers are generally designed to reduce the gas permeability of aromatic polyesters.

Other aromatic polyesters have also been developed for specialty applications such as radiation stable bioabsorbable materials. U.S. Pat. Nos. 4,510,295, 4,546,152 and 4,689,424 describe radiation sterilizable aromatic polyesters which can be used to make sutures and the like. These polymers like, poly(ethylene terephthalate), have phenylene groups in the backbone of the polymers.

However, less research has been reported on aliphatic polyesters. After Carothers initial work on polyesters, aliphatic polyesters were generally ignored because it was believed that these materials had low melting points and high solubilities. The only aliphatic polyesters that have been extensively studied are polylactones such as polylactide, polyglycolide, poly(p-dioxanone) and polycaprolactone. These aliphatic polylactones have been used primarily for bioabsorbable surgical sutures and surgical devices such as staples. Although polylactones have proven to be useful in many applications they do not meet all the needs of the medical community. For example films of polylactones do not readily transmit water vapor, therefore, are not ideally suited for use as bandages where the transmission of water vapor would be desired.

Only recently has there been renewed interest in non-lactone aliphatic polyesters. U.S. Pat. No. 5,349,028 describes the formation of very simple aliphatic polyesters based on the reaction of a diol with a dicarboxylic acid to from a prepolymer chains that is then coupled together. These polyesters are being promoted for use in fibers and molded articles because these polyesters are biodegradable after they are buried such as in a landfill. However, these materials are not disclosed as being suitable for use in surgical devices.

Thus it is an object of the present invention to provide a new class of crosslinked aliphatic polyesters and blends thereof that may be used in surgical devices such as sutures, molded devices, drug delivery matrices, coatings, lubricants and the like.

SUMMARY OF THE INVENTION

We have discovered a new class of synthetic crosslinked polymeric materials and blends thereof that may be used to produce surgical devices such as molded devices, drug delivery matrices, coatings, lubricants and the like. The invention also contemplates a process for producing the crosslinked polymers and blends thereof. The crosslinked aliphatic polyoxaesters of the present invention is a polyester comprising a first divalent repeating unit of formula I:

 O--C(O)--C(R1)(R2)--O--(R3)--O--C(R1)(R2)--C(O)--!I

and a second repeating unit selected from the group of formulas consisting of:

 --O--R12 --!U,                                  XIV

and optionally a third repeating unit with a formula selected from the group consisting of:

 --O--R4 --!A,                                   II

 --O--R5 C(O)--!B,                               III

( --O--R13 --C(O)!P --O--)L G               XI

and combinations thereof, wherein R1 and R2 are independently hydrogen or an alkyl group containing 1 to 8 carbon atoms; R3 is an alkylene unit containing from 2 to 12 carbon atoms or is an oxyalkylene group of the following formula:

-- (CH2)C --O--!D --(CH2)E --     IV

wherein C is an integer in the range of from 2 to about 5, D is an integer in the range of from about 0 to about 2,000, and E is an integer in the range of from about 2 to about 5, except when D is zero in which case E will be an integer from 2 to 12; R12 is an alkylene unit containing from 2 to 8 carbon atoms and containing an internal amine (--N(R10)--) or amide (--N(R11)--); R10 and R11 are independently hydrogen or an alkyl group containing 1 to 8 carbon atoms; A and U are independently integers in the range of from 1 to about 2,000 and preferably are indepently in the range of from 1 to about 1,000; R12 is an alkylene unit containing from 2 to 8 carbon atoms; R5 and R13 are independently selected from the group consisting of --C(R6)(R7)--, --(CH2)3 --O--, --CH2 --CH2 --O--CH2 --, --CR8 H--CH2 --, --(CH2)5 --, --(CH2)F --O--C(O)-- and --(CH2)K --C(O)--CH2 --; R6 and R7 are independently hydrogen or an alkyl containing from 1 to 8 carbon atoms; R8 is hydrogen or methyl; F and K are integers in the range of from 2 to 6; B is an integer in the range of from 1 to n such that the number average molecular weight of formula III is less than about 200,000; P is an integer in the range of from 1 to m such that the molecular weight of formula XI is less than about 1,000,000; G represents the residue minus from 1 to L hydrogen atoms from the hydroxyl group of an alcohol previously containing from 1 to about 200 hydroxyl groups; and L is an integer from about 1 to about 200; which has been crosslinked.

Additionally, this present invention describes a prepolymer comprising an aliphatic polyoxaester chemically linked to at least one polymerizable region.

DETAILED DESCRIPTION OF THE INVENTION

The aliphatic polyoxaesters of the present invention are the reaction product of an aliphatic polyoxycarboxylic acid and at least one of the following compounds: a diol (or polydiol), a lactone (or lactone oligomer), a coupling agent or combination thereof.

Suitable aliphatic alpha-oxycarboxylic acids for use in the present invention generally have the following formula:

HO--C(O)--C(R1)(R2)--O--(R3)--O--C(R1)(R2)--C(O)--OH                                                         V

wherein R1 and R2 are independently selected from the group consisting of hydrogen or an alkyl group containing from 1 to 8 carbon atoms and R3 is an alkylene containing from 2 to 12 carbon atoms or is an oxyalkylene group of the following formula:

-- (CH2)C --O--!D --(CH2)E --     IV

wherein C is an integer in the range of from about 2 to about 5, D is an integer in the range of from about 0 to about 2,000 and preferably from about 0 to about 12, and E is an integer in the range of from about 2 to about 5. These aliphatic alpha-oxycarboxylic acids may be formed by reacting diol or polydiol containing an internal amine or internal amide with an alpha-halocarboxylic acid such bromoacetic acid or chloroacetic acid under suitable conditions.

Suitable amine and amide containing diols or polydiols for use in the present invention are diol or diol repeating units with up to 8 carbon atoms having the formula:

H --(O--R12 --)U !OH,                            XIV

wherein R12 is an alkylene unit containing from 2 to 8 methylene units and containing an internal amine (--N(R10)--) or amide (--N(R11)--); R10 and R11 are independently hydrogen or an alkyl group containing 1 to 8 carbon atoms; U is an integer in the range of from 1 to about 2,000 and preferably from 1 to 1,000. Examples of suitable amine and amide containing diols include diethanol amine and 2-hydroxyl-N-(2-hydroxyethyl) acetamide. The polyoxaester may additionally contain diols or polydiols for use in the present invention are diol or diol repeating units with up to 8 carbon atoms having the formulas:

H --(O--R4 --)A !OH,                             VI

wherein R4 is an alkylene unit containing from 2 to 8 methylene units; A is an integer in the range of from 1 to about 2,000 and preferably from 1 to about 1,000. Examples of suitable diols include diols selected from the group consisting of 1,2-ethanediol (ethylene glycol), 1,2-propanediol (propylene glycol), 1,3-propanediol, 1,4-butanediol, 1,5-pentanediol, 1,3-cyclopentanediol, 1,6-hexanediol, 1,4-cyclohexanediol, 1,8-octanediol and combinations thereof. Examples of preferred polydiols include polydiols selected from the group consisting of polyethylene glycol (H --O--CH2 --CH2 --!A OH) and polypropylene glycol (H --O--CH2 --CH(CH3)--!A OH).

The polymer produced by reacting the aliphatic dioxycarboxylic acid with the diols discussed above should provide a polymer generally having the formula:

 --O--C(O)--C (R1)(R2)--O--(R3)--O--C(R1)(R2)--C(O)--(O--R.sub.12)U !N                                          VII

wherein R1, R2, R3, R12 and U are as described above; and N is an integer in the range of from about 1 to about 10,000 and preferably is in the range of from about 10 to about 1,000 and most preferably in the range of from about 50 to about 200.

Suitable lactone monomers that may be used in the present invention generally have the formula: ##STR1## These lactone monomers (or equivalent acids, if any) may be polymerized to provide polymers of the following general structures:

H --O--R5 --C(O)--!B OH                          IX

(H --O--R13 --C(O)!P --O--)L G              X

wherein R5 and R13 are independently selected from the group consisting of --C(R6)(R7)--, --(CH2)3 --O--, --CH2 --CH2 --O--CH2 --, --CR8 H--CH2 --, --(CH2)5 --, --(CH2)F --O--C(O)-- and --(CH2)K --C(O)--CH2 --; R6 and R7 are independently hydrogen or an alkyl containing from 1 to 8 carbon atoms; R8 is hydrogen or methyl; F and K are integers of from 2 to 6; B is an integer in the range of from 1 to n such that the number average molecular weight of formula IX is less than about 200,000, preferably is less than about 100,000, more preferably less than about 40,000 and most preferably less than 20,000. P is an integer in the range of from 1 to m such that the number average molecular weight of formula X is less than about 1,000,000, preferably less than 200,000, more preferably less than 40,000 and most preferably is less than 20,000; G represents the residue minus from 1 to L hydrogen atoms from the hydroxyl groups of an alcohol previously containing from 1 to about 200 hydroxyl groups; and L is an integer from 1 to about 200. Preferably G will be the residue of a dihydroxy alcohol minus both hydroxyl groups. Suitable lactone-derived repeating units may be generated from the following monomers include but are not limited to lactone monomers selected from the group consisting of glycolide, d-lactide, l-lactide, mesolactide, ε-caprolactone, p-dioxanone, trimethylene carbonate, 1,4-dioxepan-2-one, 1,5-dioxepan-2-one and combinations thereof.

The polymer formed by reacting the above described amine and amide containing diols (or polydiol) XIV and the aliphatic polyoxycarboxylic acid V may also be copolymerized in a condensation polymerization with the lactone polymers IX and X described above to form a polymer generally of the formula:

 (--C(O)--C(R1)(R2)--O--R3 --O--C(R1)(R2)--C(O)--(O--R12)U --O)S (C(O)--R5 --O)B !W                         XII

or

 (--C(O)--C(R1)(R2)--O--R3 --O--C(R1)(R2)--C(O)--(O--R12)U --O)S ( --O--R13 --C(O)!P --O--)L G!W       XIII

wherein S is an integer in the range of from about 1 to 10,000 and preferably from 1 to 1,000 and W is an integer in the range of from about 1 to about 1,000. These polymers may be made in the form of random copolymers or block copolymers. To the diols, aliphatic polyoxycarboxylic acids and lactone monomers described above there may be added a coupling agent selected from the group consisting of trifunctional or tetrafunctional polyols, oxycarboxylic acids, and polybasic carboxylic acids (or acid anhydrides thereof). The addition of the coupling agents causes the branching of long chains, which can impart desirable properties in the molten state to the polyester prepolymer. Examples of suitable polyfunctional coupling agents include trimethylol propane, glycerin, pentaerythritol, malic acid, citric acid, tartaric acid, trimesic acid, propane tricarboxylic acid, cyclopentane tetracarboxylic anhydride and combinations thereof.

The amount of coupling agent to be added before gelation occurs is a function of the type of coupling agent used and the polymerization conditions of the polyoxaester or molecular weight of the prepolymer to which it is added. Generally in the range of from about 0.1 to about 10 mole percent of a trifunctional or a tetrafunctional coupling agent may be added based on the moles of aliphatic polyoxaester polymers present or anticipated from the synthesis.

The preparation of the aliphatic polyoxaester is preferably a polymerization performed under melt polycondensation conditions in the presence of an organometallic catalyst at elevated temperatures. The organometallic catalyst is preferably a tin-based catalyst e.g. stannous octoate. The catalyst will preferably be present in the mixture at a mole ratio of diol, aliphatic polyoxycarboxylic acid and optionally lactone monomer to catalyst will be in the range of from about 5,000 to about 80,000/1. The reaction is preferably performed at a temperature no less than about 120░ C. under reduced pressure. Higher polymerization temperatures may lead to further increases in the molecular weight of the copolymer, which may be desirable for numerous applications. The exact reaction conditions chosen will depend on numerous factors, including the properties of the polymer desired, the viscosity of the reaction mixture, and the glass transition temperature and softening temperature of the polymer. The preferred reaction conditions of temperature, time and pressure can be readily determined by assessing these and other factors.

Generally, the reaction mixture will be maintained at about 220░ C. The polymerization reaction can be allowed to proceed at this temperature until the desired molecular weight and percent conversion is achieved for the copolymer, which will typically take about 15 minutes to 24 hours. Increasing the reaction temperature generally decreases the reaction time needed to achieve a particular molecular weight, but also may increase the extent of side reactions. We have found that reaction at about 220░ C. to be generally suitable.

In another embodiment, copolymers of aliphatic polyoxaester can be prepared by forming an aliphatic polyoxaester prepolymer polymerized under melt polycondensation conditions, then adding at least one lactone monomer or lactone prepolymer. The mixture would then be subjected to the desired conditions of temperature and time to copolymerize the prepolymer with the lactone monomers in a polycondensation polymerization.

The molecular weight of the prepolymer as well as its composition can be varied depending on the desired characteristic which the prepolymer is to impart to the copolymer. However, it is preferred that the aliphatic polyoxaester prepolymers from which the copolymer is prepared have a molecular weight that provides an inherent viscosity between about 0.2 to about 2.0 deciliters per gram (dl/g) as measured in a 0.1 g/dl solution of hexafluoroisopropanol at 25░ C. Those skilled in the art will recognize that the aliphatic polyoxaester prepolymers described herein can also be made from mixtures of more than one diol or dioxycarboxylic acid.

One of the beneficial properties of the aliphatic polyoxaester made by the process of this invention is that the ester linkages are hydrolytically unstable, and therefore the polymer is bioabsorbable because it readily breaks down into small segments when exposed to moist bodily tissue. In this regard, while it is envisioned that co-reactants could be incorporated into the reaction mixture of the aliphatic dioxycarboxylic acid and the diol for the formation of the aliphatic polyoxaester prepolymer, it is preferable that the reaction mixture does not contain a concentration of any co-reactant which would render the subsequently prepared polymer nonabsorbable. Preferably, the reaction mixture is substantially free of any such co-reactants if the resulting polymer is rendered nonabsorbable.

These aliphatic polyoxaesters described herein and those described in Ser. No. 08/399,308, filed Mar. 6, 1995 and assigned to Ethicon, now U.S. Pat. No. 5,464,929 may be blended together with other homopolymers, copolymers and graft copolymers to impart new properties to the material formed by the blend. The other polymers which the aliphatic polyoxaesters may be blended with include but are not limited to homopolymer and copolymer of lactone type polymers with the repeating units described by Formula VIII, aliphatic polyurethanes, polyether polyurethanes, polyester polyurethanes polyethylene copolymers (such as ethylene-vinyl acetate copolymers and ethylene ethyl acrylate copolymers), polyamides, polyvinyl alcohols, poly(ethylene oxide), polypropylene oxide, polyethylene glycol, polypropylene glycol, polytetramethylene oxide, polyvinyl pyrrolidone, polyacrylamide, poly(hydroxy ethyl acrylate), poly(hydroxyethyl methacrylate), absorbable polyoxalates, absorbable polyanhydrides and combinations thereof. The copolymers (i.e. containing two or more repeating units) including random, block and segmented copolymers. Suitable lactone-derived repeating units may be generated from the following monomers include but are not limited to lactone monomers selected from the group consisting of glycolide, d-lactide, l-lactide, meso-lactide, ε-caprolactone, p-dioxanone, trimethylene carbonate, 1,4-dioxepan-2-one, 1,5-dioxepan-2-one and combinations thereof. The blends may contain about 1 weight percent to about 99 weight percent of the aliphatic polyoxaesters containing amines and/or amido groups.

For some applications it may be desirable to add additional ingredients such as stabilizers, antioxidants radiopacifiers, fillers or the like.

The aliphatic polyoxaesters and other polymers may be blended using conventional mixing processes known in the art. For example a blend can be prepared using a two-roll mill, an internal mixer (such as a Brabender or Banbury mixer), an extruder (such as a twin screw extruder) or the like.

The polymers and blends of this invention can be melt processed by numerous methods to prepare a vast array of useful devices. These polymers and blends can be injection or compression molded to make implantable medical and surgical devices, especially wound closure devices. The preferred wound closure devices are surgical clips, staples and sutures. Alternatively, the polymers blends can be extruded to prepare fibers. The filaments thus produced may be fabricated into sutures or ligatures, attached to surgical needles, packaged, and sterilized by known techniques. The polymer and blends of the present invention may be spun as multifilament yarn and woven or knitted to form sponges or gauze, (or non-woven sheets may be prepared) or used in conjunction with other molded compressive structures as prosthetic devices within the body of a human or animal where it is desirable that the structure have high tensile strength and desirable levels of compliance and/or ductility. Useful embodiments include tubes, including branched tubes, for artery, vein or intestinal repair, nerve splicing, tendon splicing, sheets for typing up and supporting damaged surface abrasions, particularly major abrasions, or areas where the skin and underlying tissues are damaged or surgically removed.

Additionally, the polymers and blends can be molded to form films which, when sterilized, are useful as adhesion prevention barriers. Another alternative processing technique for the polymer and blends of this invention includes solvent casting, particularly for those applications where a drug delivery matrix is desired.

In more detail, the surgical and medical uses of the filaments, films, and molded articles of the present invention include, but are not necessarily limited to:

Knitted products, woven or non-woven, and molded products including:

a. burn dressings

b. hernia patches

c. medicated dressings

d. fascial substitutes

e. gauze, fabric, sheet, felt or sponge for liver hemostasis

f. gauze bandages

g. arterial graft or substitutes

h. bandages for skin surfaces

i. suture knot clip

j. orthopedic pins, clamps, screws, and plates

k. clips (e.g., for vena cava)

l. staples

m. hooks, buttons, and snaps

n. bone substitutes (e.g., mandible prosthesis)

o. intrauterine devices (e.g., spermicidal devices)

p. draining or testing tubes or capillaries

q. surgical instruments

r. vascular implants or supports

s. vertebral discs

t. extracorporeal tubing for kidney and heart-lung machines

u. artificial skin and others

v. catheters (including, but not limited to, the catheters described in U.S. Pat. No. 4,883,699 which is hereby incorporated by reference)

w. scaffoldings for tissue engineering applications.

In another embodiment, the polymers and blends (including prepolymers and suitable crosslinked polymers), can be used to coat a surface of a surgical article to enhance the lubricity of the coated surface. The polymer blends may be applied as a coating using conventional techniques. For example, the polymers and blends may be solubilized in a dilute solution of a volatile organic solvent, e.g. acetone, methanol, ethyl acetate or toluene, and then the article can be immersed in the solution to coat its surface. Once the surface is coated, the surgical article can be removed from the solution where it can be dried at room or elevated temperatures until the solvent and any residual reactants are removed.

For use in coating applications the polymer blends should exhibit an inherent viscosity (this is the initial IV for crosslinkable polymers), as measured in a 0.1 gram per deciliter (g/dl) of hexafluoroisopropanol (HFIP), between about 0.05 to about 2.0 dl/g, preferably about 0.10 to about 0.80 dl/g. If the inherent viscosity (which would be the final IV of a crosslinked polymer) were less than about 0.05 dl/g, then the polymer blends may not have the integrity necessary for the preparation of films or coatings for the surfaces of various surgical and medical articles. On the other hand, although it is possible to use polymer blends with an inherent viscosity greater than about 2.0 dl/g (this is the initial IV of the crosslinkable polymer), it may be exceedingly difficult to do so.

Although it is contemplated that numerous surgical articles (including but not limited to endoscopic instruments) can be coated with the polymer blends of this invention to improve the surface properties of the article, the preferred surgical articles are surgical sutures and needles. The most preferred surgical article is a suture, most preferably attached to a needle. Preferably, the suture is a synthetic absorbable suture. These sutures are derived, for example, from homopolymers and copolymers of lactone monomers such as glycolide, lactide, ε-caprolactone, 1,4-dioxanone, and trimethylene carbonate. The preferred suture is a braided multifilament suture composed of polyglycolide or poly(glycolide-co-lactide).

The amount of coating to be applied on the surface of a braided suture can be readily determined empirically, and will depend on the particular copolymer and suture chosen. Ideally, the amount of coating applied to the surface of the suture may range from about 0.5 to about 30 percent of the weight of the coated suture, more preferably from about 1.0 to about 20 weight percent, most preferably from 1 to about 5 weight percent. If the amount of coating on the suture were greater than about 30 weight percent, then it may increase the risk that the coating may flake off when the suture is passed through tissue.

Sutures coated with the polymers and blends of this invention are desirable because they have a more slippery feel, thus making it easier for the surgeon to slide a knot down the suture to the site of surgical trauma. In addition, the suture can be passed through body tissue more easily, thereby reducing tissue trauma. These advantages are exhibited in comparison to sutures which do not have their surfaces coated with the polymers and blends of this invention.

In another embodiment of the present invention when the article is a surgical needle, the amount of coating applied to the surface of the article is an amount which creates a layer with a thickness ranging preferably between about 2 to about 20 microns on the needle, more preferably about 4 to about 8 microns. If the amount of coating on the needle were such that the thickness of the coating layer was greater than about 20 microns, or if the thickness was less than about 2 microns, then the desired performance of the needle as it is passed through tissue may not be achieved.

In yet another embodiment of the present invention, the polymers and blends can be used as a pharmaceutical carrier in a drug delivery matrix. To form this matrix the polymers and blends would be mixed with a therapeutic agent to form the matrix. The variety of different therapeutic agents which can be used in conjunction with the polymer blends of the present invention is vast. In general, therapeutic agents which may be administered via the pharmaceutical compositions of the invention include, without limitation: antiinfectives such as antibiotics and antiviral agents; analgesics and analgesic combinations; anorexics; antihelmintics; antiarthritics; antiasthmatic agents; anticonvulsants; antidepressants; antidiuretic agents; antidiarrheals; antihistamines; antiinflammatory agents; antimigraine preparations; antinauseants; antineoplastics; antiparkinsonism drugs; antipruritics; antipsychotics; antipyretics, antispasmodics; anticholinergics; sympathomimetics; xanthine derivatives; cardiovascular preparations including calcium channel blockers and beta-blockers such as pindolol and antiarrhythmics; antihypertensives; diuretics; vasodilators including general coronary, peripheral and cerebral; central nervous system stimulants; cough and cold preparations, including decongestants; hormones such as estradiol and other steroids, including corticosteroids; hypnotics; immunosuppressives; muscle relaxants; parasympatholytics; psychostimulants; sedatives; and tranquilizers; and naturally derived or genetically engineered proteins, polysaccharides, glycoproteins, or lipoproteins.

The drug delivery matrix may be administered in any suitable dosage form such as oral, parenteral, a subcutaneously as an implant, vaginally or as a suppository. Matrix formulations containing the polymers and blends may be formulated by mixing one or more therapeutic agents with the polyoxaester. The therapeutic agent, may be present as a liquid, a finely divided solid, or any other appropriate physical form. Typically, but optionally, the matrix will include one or more additives, e.g., nontoxic auxiliary substances such as diluents, carriers, excipients, stabilizers or the like. Other suitable additives may be formulated with the polymer blend and pharmaceutically active agent or compound, however, if water is to be used it should be added immediately before administration.

The amount of therapeutic agent will be dependent upon the particular drug employed and medical condition being treated. Typically, the amount of drug represents about 0,001% to about 70%, more typically about 0.001% to about 50%, most typically about 0.001% to about 20% by weight of the matrix.

The quantity and type of polymers and blends incorporated into the parenteral will vary depending on the release profile desired and the amount of drug employed. The product may contain blends of polymers having different molecular weights to provide the desired release profile or consistency to a given formulation.

The polymers and blends, upon contact with body fluids including blood or the like, undergoes gradual degradation (mainly through hydrolysis) with concomitant release of the dispersed drug for a sustained or extended period (as compared to the release from an isotonic saline solution). This can result in prolonged delivery (over, say 1 to 2,000 hours, preferably 2 to 800 hours) of effective amounts (say, 0.0001 mg/kg/hour to 10 mg/kg/hour) of the drug. This dosage form can be administered as is necessary depending on the subject being treated, the severity of the affliction, the judgment of the prescribing physician, and the like.

Individual formulations of drugs and polymer or blend may be tested in appropriate in vitro and in vivo models to achieve the desired drug release profiles. For example, a drug could be formulated with a polymer or blend and orally administered to an animal. The drug release profile could then be monitored by appropriate means such as, by taking blood samples at specific times and assaying the samples for drug concentration. Following this or similar procedures, those skilled in the art will be able to formulate a variety of formulations.

The polymers and blends of the present invention can be crosslinked to affect mechanical properties. Crosslinking may either be chemically or physical. Chemically crosslinked polymer chains are connected by covalent bonds, which can be formed by reactive groups contained on the polymers, the addition of crosslinking enhancers and/or irradiation (such as gamma-irradiation). Physical crosslinked on the other hand connects the polymer chains through non-covalent bonds such as van der Waals interactions, hydrogen bonding or hydrophobic interactions. In particular, crosslinking can be used to control the water swellability of said invention.

For example, Formulas VII A and VII B may be endcapped with one or more crosslinkable regions. Similarly, Formula XII and XIII may be crosslinked by attaching one or more polymerizable regions to an amine group.

The polymerizable regions are preferably polymerizable by photoinitiation by free radical generation, most preferably in the visible or long wavelength ultraviolet radiation. The preferred polymerizable regions are acrylates, diacrylates, oligoacrylates, methacrylates, dimethacrylates, oligomethoacrylates, or other biologically acceptable photopolymerizable groups.

Other initiation chemistries may be used besides photoinitiation. These include, for example, water and amine initiation schemes with isocyanate or isothiocyanate containing macromers used as the polymerizable regions.

Useful photoinitiaors are those which can be used to initiate by free radical generation polymerization of the macromers without cytotoxicity and within a short time frame, minutes at most and most preferably seconds. Preferred dyes as initiators of choice for long wave length ultraviolet (LWUV) or visible light initiation are ethyl eosin, 2,2-dimethoxy-2-phenyl acetophenone, other acetophenone derivatives, and camphorquinone. Crosslinking and polymerization may be initiated among macromers by a light activated free-radical polymerization initiator such as 2,2-dimethoxy-2-phenyl acetophenone, other acetophenone derivatives, and camphorquinone. In other cases, crosslinking and polymerization are initiated among macromers by a light-activated free-radical polymerization initiator such as 2,2-dimethoxy-2-phenylacetophenone or a combination of ethyl eosin (10-4 to 10-2 M) and triethanol amine (0.001 to 0.1M), for example.

The choice of the photoinitiator is largely dependent on the photopolymerizable regions. Although we do no wish to be limited by scientific theory, it is believed that the macromer includes at least one carbon-carbon double bond, light absorption by the dye can cause the dye to assume a triplet state, the triplet state subsequently reacting with the amine to form a free radical which initiates polymerization. Preferred dyes for use with these materials include eosin dye and initiators such as 2,2-dimethyl-2-phenylacetophenone, 2-methoxy-2-phenylacetophenone, and camphorquinone. Using such initiators, copolymers may be polymerized in situ by LWUV light or by laser light of about 514 nm, for example.

Initiation of polymerization (crosslinking) is accomplished by irradiation with light at a wavelength of between about 200-700 nm, most preferably in the long wavelength ultraviolet range or visible range, 320 nm or higher, most preferably about 514 nm or 365 nm.

There are several photooxidizable and photoreductible dyes that may be used to initiate polymerization (crosslinking). These include acridine dyes, for example, acriblarine; thiazine dyes, for example, thionine; xanthine dyes, for example, rose bengal; and phenazine dyes, for example, methylene blue. These are used with cocatalysis such as amines, for example, triethanolamine; sulphur compounds, for example, RSO2 R1 ; heterocycles, for example, imidazole; enolates; organometallics; and other compounds, such as N-phenyl glycine. Other initiators include camphorquinones and acetophenone derivatives.

Thermal polymerization (crosslinking) initiator systems may also be used. Thermal initiators may be selected to allow polymerization to be initiated at a desired temperature. At times it may be desired to use a high temperature to initiate polymerization such as during a molding process. For many medical uses it will be desired to use systems that will initiate free radical polymerization at physiological temperatures include, for example, potassium persulfate, with or without tetramethyl ethylenediamine; benzoylperoxide, with or without triethanolamine; and ammonium persulfate with sodium bisulfite.

The crosslinked polymers (including copolymers) and blends (hereinafter polymers) can be prepared and used for many of the same uses as described heretofor. In addition, crosslinked polymers can be used for the prevention of surgical adhesions, tissue adhesions, tissue coatings and in tissue engineering.

A preferred application is a method of reducing formation of adhesions after a surgical procedure in a patient. The method includes coating damaged tissue surfaces in a patient with an aqueous solution of a light-sensitive free-radical polymerization initiator and a macromer solution as described above. The coated tissue surfaces are exposed to light sufficient to polymerize the macromer. The light-sensitive free-radical polymerization initiator may be a single compound (e.g., 2,2-dimethoxy-2-phenyl acetophenone) or a combination of a dye and a cocatalyst (e.g., ethyl eosin and triethanol amine).

Additionally, the crosslinked polymers can also be used to form hydrogels which are a three dimensional network of hydrophilic polymers in which a large amount of water is present. In general the amount of water present in a hydrogel is at least 20 weight percent of the total weight of the dry polymer. The most characteristic property of these hydrogels is that it swells in the presence of water and shrinks in the absence of water. The extent of swelling (equilibrium water content) is determined by the nature (mainly the hydrophilicity) of the polymer chains and the crosslinking density.

The kinetics of hydrogel swelling is limited by the diffusion of water through the outer layers of the dried hydrogel. Therefore, while hydrogels swell to a large extent in water, the time it takes to reach equilibrium swelling may be significant, depending on the size and shape of the hydrogel. To reduce the amount of time it takes for a hydrogel to reach equilibrium, hydrogel foams may be used. Hydrogels foams may be made by crosslinking polymers in the presence of gas bubbles. The hydrogels foams prepared with macroscopic gas cells will have an open celled structure similar to sponges except that the pore size will generally be an order of magnitude larger.

Hydrogels may be used for many of same uses that have been described for polyoxaesters such as wound dressings materials, since the crosslinked hydrogels are durable, non-antigenic, and permeable to water vapor and metabolites, while securely covering the wound to prevent bacterial infection. Hydrogels may also be used for coatings in general and medial coatings in particular. Hydrogel coatings may provide a smooth slippery surface and prevent bacterial colonization on the surface of the medical instrument. For example hydrogels may be used as coatings on urinary catheter surfaces to improve its biocompatability. Hydrogels may also be used in a variety of applications where the mechanical swelling of the hydrogel is useful such as in catheters as a blend component with a biocompatable elastomer (such as the elastomer described in U.S. Pat. No. 5,468,253 hereby incorporated by reference). Additionally, hydrogels could be used for drug delivery or immobilization of enzyme substrates or cell encapsulization. Other uses for hydrogels have been described in the literature many of which are discussed in Chapter One of Hydrogels and Biodegradable Polymers for Bioapplications, published by the Amercian Chemical Society (which is hereby incorporated by reference herein).

Crosslinking to form crosslinked structures can be performed in a variety of ways. For example the polymers may be crosslinked while being synthesized such as by utilizing multifunctional monomers or oligomers. However, crosslinking at other times is also advantageous. For example, crosslinking may be performed during the manufacture of a device such by adding a thermal initiator to the polymer prior to injection molding a device. Additionally, crosslinking of a polymerizable region with a photoinitiator may be performed during stereolithography to form devices. European Patent Application 93305586.5 describes the process for performing stereolithography (with photopolymerizable materials). As previously discussed photoinitiation may be used in vivo to crosslink the polymers of the present invention for various wound treatments such as adhesion prevention and wound sealing.

Coating may also be applied to devices and crosslinked in situ to form films that will conform to the surface of the device.

In a further embodiment of the present invention the polyoxaestes containing amines and/or amido groups and polymer blends of the present invention can be used in tissue engineering applications as supports for cells. Appropriate tissue scaffolding structures are known in the art such as the prosthetic articular cartilage described in U.S. Pat. No. 5,306,311, the porous biodegradable scaffolding described in WO 94/25079, and the prevascularized implants described in WO 93/08850 (all hereby incorporated by reference herein). Methods of seeding and/or culturing cells in tissue scaffoldings are also known in the art such as those methods disclosed in EPO 422 209 B1, WO 88/03785, WO 90/12604 and WO 95/33821 (all hereby incorporated by reference herein).

The Examples set forth below are for illustration purposes only, and are not intended to limit the scope of the claimed invention in any way. Numerous additional embodiments within the scope and spirit of the invention will become readily apparent to those skilled in the art.

EXAMPLE 1 Preparation of 3,6-Dioxaoctanedioic acid dimethylester ##STR2##

The diacid, 3,6-dioxaoctanedioic acid, was synthesized by oxidation of triethylene glycol. The oxidation was carried out in a 500 milliliter, three-neck round bottom flask equipped with a thermometer, an additional funnel, a gas absorption tube and a magnetic spinbar. The reaction flask was lowered into an oil bath resting upon a magnetic stirrer. To the reaction flask was added 157.3 ml of a 60% nitric acid solution; 37.0 g of triethylene glycol was added to the additional funnel. The contents of the flask were heated to 78░-80░ C. A test tube containing 0.5 g of glycol and one milliliter of concentrated nitric acid was warmed in a water bath until brown fumes started appearing. The contents were then added to the reaction flask. The mixture was stirred for a few minutes; the glycol was then carefully added. The rate of addition had to be monitored extremely carefully to keep the reaction under control. The addition rate was slow enough so that the temperature of the exothermic reaction mixture was maintained at 78░-82░ C. After the addition was completed (80 minutes), the temperature of the reaction mixture was maintained at 78░-80░ C. for an additional hour. While continuing to maintain this temperature range, the excess nitric acid and water was then distilled off under reduced pressure (water suction). The syrupy residue was cooled; some solids appeared. The reaction product had the IR and NMR spectra expected for the dicarboxylic acid; the crude product was used as such for esterification.

Esterification of the crude 3,6-dioxaoctanedioic acid was accomplished as follows: To the reaction flask containing 36 g of the crude diacid, was added 110 ml of methanol. This was stirred for 3 days at room temperature after which 15 g of sodium bicarbonate was added and stirred overnight. The mixture was filtered to remove solids. To the liquor was added an additional 10 g of sodium bicarbonate; this mixture was stirred overnight. The mixture was again filtered; the liquor was fractionally distilled.

NMR analysis of the esterified product showed a mixture of dimethyl triglycolate (78.4 mole %) and monomethyltriglycolate (21.6 mole %). No significant condensation of diacid was observed.

EXAMPLE 2 Preparation of polyoxaester from the methyl esters of 3,6-dioxaoctanedioic acid and ethylene glycol ##STR3##

A flame dried, mechanically stirred, 50-milliliter glass reactor suitable for polycondensation reaction, was charged with 20.62 g (approximately 0.1 mole) of the methyl esters of 3,6-dioxaoctanedioic acid from Example 1, 18.62 g (0.3 mole) of distilled ethylene glycol, and 0.0606 ml of a solution of 0.33M stannous octoate in toluene. After purging the reactor and venting with nitrogen, the temperature was gradually raised over the course of 26 hours to 180░ C. A temperature of 180░ C. was then maintained for another 20 hours; all during these heating periods under nitrogen at one atmosphere, the methanol formed was collected. The reaction flask was allowed to cool to room temperature; it was then slowly heated under reduced pressure (0.015-1.0 mm) over the course of about 32 hours to 160░ C., during which time additional distillates were collected. A temperature of 160░ C. was maintained for 4 hours after which a sample, a few grams in size, of the polymer formed was taken. The sample was found to have an inherent viscosity (I.V.) of 0.28 dl/g, as determined in hexaflouroisopropanol (HFIP) at 25░ C. at a concentration of 0.1 g/dl. The polymerization was continued under reduced pressure while raising the temperature, in the course of about 16 hours, from 160░ C. to 180░ C.; a temperature of 180░ C. was maintained at for an additional 8 hours, at which time a polymer sample was taken and found to have an I.V. of 0.34 dl/g. The reaction was continued under reduced pressure for another 8 hours at 180░ C. The resulting polymer has an inherent viscosity of 0.40 dl/g, as determined in HFIP at 25░ C. and at a concentration of 0.1 g/dl.

EXAMPLE 3 Preparation of polyoxaester with 3,6,9-trioxaundecanedioic acid and ethylene glycol

A flame dried, mechanically stirred, 250-milliliter glass reactor, suitable for polycondensation reaction, was charged with 44.44 g (0.2 mole) of 3,6,9-trioxaundecanedioic acid, 62.07 g (1.0 mole) of distilled ##STR4## ethylene glycol, and 9.96 milligrams of dibutyltin oxide. After purging the reactor and venting with nitrogen, the contents of the reaction flask were gradually heated under nitrogen at one atmosphere, in the course of about 32 hours, to 180░ C., during which time the water formed was collected. The reaction mass was allowed to cool to room temperature. The reaction mass was then heated under reduced pressure (0.015-1.0 mm), gradually increasing the temperature to 180░ C. in about 40 hours; during this time additional distillates were collected. The polymerization was continued under reduced pressure while maintaining 180░ C. for an additional 16 hours. The resulting polymer has an inherent viscosity of 0.63 dl/g as determined in HFIP at 25░ C. and at a concentration of 0.1 g/dl.

EXAMPLE 4 Preparation of polyoxaester with polyglycol diacid and ethylene glycol ##STR5##

A flame dried, mechanically stirred, 500-milliliter glass reactor (suitable for polycondensation reaction) was charged with 123.8 g (0.2 mole) polyglycol diacid (molecular weight about 619), 62.07 g (1.0 mole) of distilled ethylene glycol, and 9.96 milligrams of dibutyltin oxide. After purging the reactor and venting with nitrogen, the contents of the reaction flask was heated under nitrogen at one atmosphere, gradually increasing the temperature to 200░ C. in about 32 hours; during this time the water formed was collected. The reaction flask was heated gradually under reduced pressure (0.015-1.0 mm) from room temperature to 140░ C. in about 24 hours, during which time additional distillates were collected. A polymer sample of about ten grams was taken at this stage, and found to have an I.V. of 0.14 dl/g in HFIP at 25░ C., 0.1 g/dl. The polymerization was continued under reduced pressure while heating from 140░ C. to 180░ C. in about 8 hours, and then maintained at 180░ C. for an additional 8 hours. A polymer sample was again taken and found to have an I.V. of 0.17 dl/g. The reaction temperature was then increased to 190░ C. and maintained there under reduced pressure for an additional 8 hours. The resulting polymer has an inherent viscosity of 0.70 dl/g as determined in HFIP at 25░ C. and at a concentration of 0.1 g/dl.

EXAMPLE 5 Copolymer of polyoxaester/caprolactone/trimethylene carbonate at 5/5/5 by weight

A flame dried, 50-milliliter, round bottom single-neck flask was charged with 5 grams of the aliquot of the polyoxaester of Example 4 having an I.V. of 0.14 dl/g, 5.0 grams (0.0438 mole) of ε-caprolactone, 5.0 grams (0.0490 mole) of trimethylene carbonate, and 0.0094 milliliters of a 0.33 molar solution of stannous octoate in toluene.

The flask was fitted with a magnetic stirrer bar. The reactor was purged with nitrogen three times before venting with nitrogen. The reaction mixture was heated to 160░ C. and maintained at this temperature for about 6 hours. The copolymer was dried under vacuum (0.1 mm Hg) at 80░ C. for about 16 hours to remove any unreacted monomer. The copolymer has an inherent viscosity of 0.34 dl/g, as determined in HFIP at 25░ C. and at a concentration of 0.1 g/dl. The copolymer is a viscous liquid at room temperature. The mole ratio of polyoxaester/PCL/PTMC was found by NMR analysis to be 47.83/23.73/28.45.

EXAMPLE 6 Copolymer of polyoxaester/caprolactone/glycolide at 6/8.1/0.9 by weight

A flame dried, 25-milliliter, round bottom, single-neck flask was charged with 6 grams of the polyoxaester of Example 4 having an I.V. of 0.17 dl/g., 8.1 grams (0.0731 mole) of ε-caprolactone, 0.9 grams (0.008) mole of glycolide and 0.0080 milliliters of a 0.33 molar stannous octoate solution in toluene. The flask was fitted with a magnetic stirrer bar. The reactor was purged with nitrogen three times before venting with nitrogen. The reaction mixture was heated to 160░ C. and maintained at this temperature for about 18 hours. The copolymer has an inherent viscosity of 0.26 dl/g in HFIP at 25░ C. and at a concentration of 0.1 g/dl. The copolymer is solid at room temperature. The mole ratio of polyoxaester/PCL/PGA/caprolactone was found by NMR analysis to be 56.54/37.73/3.79/1.94.

EXAMPLE 7 In Vitro Hydrolysis

The polyoxaester of Example 3 was tested for in vitro hydrolysis at both 50░ C. and at reflux temperature. A 100 mg sample of the polyoxaester, placed in 100 ml of a phosphate buffer solution (0.2M in phosphate, pH 7.27), was completely hydrolyzed in about 7 days at 50░ C., whereas at reflux it was completely hydrolyzed in about 16 hours.

EXAMPLE 8 Vitro Hydrolysis

Polyoxaester of Example 2 was tested for in vitro hydrolysis at 50░ C. and at reflux temperature. A 100 mg sample of the polyoxaester, placed in a 100 ml buffer solution (pH 7.27), was completely hydrolyzed in about 25 days at 50░ C, whereas at reflux it was completely hydrolyzed in about 16 hours.

Patent Citations
Cited PatentFiling datePublication dateApplicantTitle
US4440922 *Apr 13, 1983Apr 3, 1984Eastman Kodak Co.Polyester containers having improved gas barrier properties
US4510295 *Jan 20, 1983Apr 9, 1985Ethicon, Inc.Polyester copolymers; fibers, sutures, surgical products
US4546152 *Mar 7, 1984Oct 8, 1985Ethicon, Inc.Poly(p-dioxanone) polymers having improved radiation resistance
US4552948 *Mar 29, 1985Nov 12, 1985Eastman Kodak CompanyPhenylenedioxydiacetic acids, terephthalic acid
US4689424 *Jun 29, 1982Aug 25, 1987Ethicon, Inc.Radiation sterilizable absorbable polymeric materials and methods for manufacturing the same
US4703069 *Jun 27, 1986Oct 27, 1987Imperial Chemical Industries PlcPolyether polyols, their manufacture and use in polyurethanes production
US4963641 *May 30, 1989Oct 16, 1990Eastman Kodak CompanyContainers for carbonated beverages, foods, medicine
US5349028 *Apr 20, 1993Sep 20, 1994Showa Highpolymer Co., Ltd.Biodegradability, heat resistance, tensile strength; diisocyanate coupling agent
US5464929 *Mar 6, 1995Nov 7, 1995Ethicon, Inc.Bioabsorbable
Referenced by
Citing PatentFiling datePublication dateApplicantTitle
US5844017 *Nov 17, 1997Dec 1, 1998Ethicon, Inc.Prepolymers of absorbable polyoxaesters containing amines and/or amido groups
US5859150 *Nov 5, 1997Jan 12, 1999Ethicon, Inc.Prepolymers of absorbable polyoxaesters
US5897591 *Jan 7, 1998Apr 27, 1999Kobayashi; MasanoriImplant for injured tendon of digitus manus
US5962023 *Nov 6, 1996Oct 5, 1999Ethicon, Inc.Hydrogels containing absorbable polyoxaamides
US6074660 *Apr 20, 1998Jun 13, 2000Ethicon, Inc.Medical equipment
US6100346 *Apr 20, 1998Aug 8, 2000Ethicon, Inc.May be used to produce hydrogels, surgical devices such as catheters, molded devices, and the like
US6147168 *Apr 20, 1998Nov 14, 2000Ethicon, Inc.Copolymers of absorbable polyoxaesters
US6224894Aug 11, 2000May 1, 2001Ethicon, Inc.Medical equipment
US6403655Aug 17, 1999Jun 11, 2002Ethicon, Inc.Method of preventing adhesions with absorbable polyoxaesters
US6575986Feb 26, 2001Jun 10, 2003Ethicon, Inc.Scaffold fixation device for use in articular cartilage repair
US6626950Jun 28, 2001Sep 30, 2003Ethicon, Inc.Composite scaffold with post anchor for the repair and regeneration of tissue
US6743232Feb 26, 2001Jun 1, 2004David W. OverakerTissue scaffold anchor for cartilage repair
US6866860Dec 19, 2002Mar 15, 2005Ethicon, Inc.Cationic alkyd polyesters for medical applications
US6872799Dec 18, 2002Mar 29, 2005Ethicon, Inc.Functionalized polymers for medical applications
US6932974Feb 9, 2001Aug 23, 2005Ethicon, Inc.Sterile barrier
US6967234Dec 18, 2002Nov 22, 2005Ethicon, Inc.synthetic/biodegradable/biocompatible; comprises polybasic acid, monoglyceride, and lactone monomers
US7005136Mar 29, 2002Feb 28, 2006Ethicon, Inc.Bone replacement materials utilizing bioabsorbable liquid polymers
US7026374Jun 25, 2002Apr 11, 2006Aruna NathanInjectable microdispersions for medical applications
US7030127Jun 29, 2001Apr 18, 2006Ethicon, Inc.Composition and medical devices utilizing bioabsorbable polymeric waxes
US7034037Dec 18, 2002Apr 25, 2006Ethicon, Inc.Compositions and medical devices utilizing bioabsorbable polymeric waxes and rapamycin
US7101566Jun 28, 2002Sep 5, 2006Ethicon, Inc.Polymer coated microparticles for sustained release
US7163563Jul 15, 2002Jan 16, 2007Depuy Products, Inc.Unitary surgical device and method
US7244441Sep 27, 2004Jul 17, 2007Scios, Inc.Coated with or otherwise containing especially an arylalkylpiperidinyl-(or piperazinyl)-carbonylindole in which the 3-position of the indole ring is oxalyl-substituted; controls, reduces, or prevents restenosis, inflammation, and complications associated with implants
US7326426Mar 29, 2002Feb 5, 2008Ethicon, Inc.Compositions and medical devices utilizing bioabsorbable liquid polymers
US7354627Dec 22, 2004Apr 8, 2008Depuy Products, Inc.Method for organizing the assembly of collagen fibers and compositions formed therefrom
US7368125Jun 5, 2002May 6, 2008Ethicon, Inc.Amphiphilic polymers for medical applications
US7569233Apr 20, 2005Aug 4, 2009Depuy Products, Inc.laminating a bioprosthetic device with a synthetic layer positioned between two natural extracellular matrix; soft tissue attachment, reinforcement, reconstruction; small intestine submucosa; tissue repair and regeneration of connective tissue
US7572929Mar 27, 2006Aug 11, 2009Ethicon, Inc. - UsaBiodegradable or water-soluble dithiocarbonate macromers and polymers derived therefrom that contain thioether linkages especially adapted for pharmaceutical and medical applications
US7595062Jul 28, 2005Sep 29, 2009Depuy Products, Inc.Orthopedic implant of self-assembled porous structure comprising a collagen type I matrix in its native alpha-helical structure, and a sheet of naturally occurring submucosal matrix secured thereto; sponge as scaffold for tissue repair
US7604817Sep 3, 2003Oct 20, 2009Ethicon Endo-Surgery, Inc.Porous bioabsorbable bag containing materials having different rates of absorption and binding gel; promotes controlled new growth into voids or cavities; reconstructive soft tissue surgery, wound healing; minimizing collapse of surrounding host tissue
US7611484Apr 28, 2004Nov 3, 2009Ethicon, Inc.Methods and devices for treating diseased blood vessels
US7723515Jan 26, 2009May 25, 2010Codman & Shurtleff, Inc.Methylene blueŚcurcumin analog for the treatment of alzheimer's disease
US7745670Dec 24, 2008Jun 29, 2010Codman & Shurtleff, Inc.1-hydroxyl 3,5-bis(4'-hydroxyl styryl)benzene; curcuminoid for treating Alzheimer's disease
US7819918Dec 29, 2003Oct 26, 2010Depuy Products, Inc.Implantable tissue repair device
US7824701Feb 25, 2003Nov 2, 2010Ethicon, Inc.from monomers such as lactide, glycolide, dioxanone, and caprolactone; living cells migrate and populate scaffold; orthopedics, foot surgery
US7875064Jul 9, 2004Jan 25, 2011Ethicon, Inc.Absorbable bone anchor
US7875296Nov 29, 2007Jan 25, 2011Depuy Mitek, Inc.Conformable tissue repair implant capable of injection delivery
US7897384Sep 8, 2003Mar 1, 2011Ethicon, Inc.Chondrocyte therapeutic delivery system
US7901461Dec 5, 2003Mar 8, 2011Ethicon, Inc.Viable tissue repair implants and methods of use
US7906643Feb 1, 2010Mar 15, 2011Codman & Shurtleff, Inc.Methylene blue-curcumin analog for the treatment of Alzheimer's Disease
US7914808Jul 15, 2002Mar 29, 2011Depuy Products, Inc.Hybrid biologic/synthetic porous extracellular matrix scaffolds
US7927599Dec 4, 2008Apr 19, 2011Ethicon, Inc.Chondrocyte therapeutic delivery system
US7959938Mar 13, 2006Jun 14, 2011Intarcia Therapeutics, Inc.Polyoxaester suspending vehicles for use with implantable delivery systems
US7985776Jun 27, 2008Jul 26, 2011Codman & Shurtleff, Inc.charged curcuminoid such as bisdemethoxycurcumin, curcumin and glycinates, as well as hybrid compounds of bisdemethoxycurcumin and resveratrol, fisetin, or honokiol; bioavailability
US8012205 *Jul 15, 2002Sep 6, 2011Depuy Products, Inc.Cartilage repair and regeneration device
US8016867Oct 28, 2004Sep 13, 2011Depuy Mitek, Inc.Graft fixation device and method
US8025896Jul 15, 2002Sep 27, 2011Depuy Products, Inc.Suspending pieces of a natural occurring extracellular tissue in a liquid and freeze drying for usage as repairing or regenerating body tissue; implantable
US8076294Jul 25, 2008Dec 13, 2011Advanced Technologies And Regenerative Medicine, Llc.Collagen-related peptides and uses thereof
US8092528May 27, 2005Jan 10, 2012Depuy Spine, Inc.Intervertebral ligament having a helical bone fastener
US8092529Jul 15, 2002Jan 10, 2012Depuy Products, Inc.Meniscus regeneration device
US8114159Nov 20, 2006Feb 14, 2012Depuy Spine, Inc.Anterior spinal vessel protector
US8114430May 3, 2011Feb 14, 2012Intarcia Therapeutics, Inc.Polyoxaester suspending vehicles for use with implantable delivery systems
US8137686Apr 20, 2004Mar 20, 2012Depuy Mitek, Inc.Nonwoven tissue scaffold
US8137702Dec 29, 2010Mar 20, 2012Depuy Mitek, Inc.Conformable tissue repair implant capable of injection delivery
US8153117Aug 10, 2006Apr 10, 2012Depuy Mitek, Inc.Genetically altered chondrocyte expresses a therapeutic agent; implanting a biocompatible substrate into a target region; brain, heart, liver, kidney, intestinal tract, spleen, smooth and skeletal muscles, eye, ganglions, lungs, gonads, pancreas
US8167920Oct 24, 2006May 1, 2012Codman & Shurtleff, Inc.Intranasal delivery of compounds that reduce intrancranial pressure
US8221780Jun 29, 2006Jul 17, 2012Depuy Mitek, Inc.Nonwoven tissue scaffold
US8226715Jun 30, 2003Jul 24, 2012Depuy Mitek, Inc.Scaffold for connective tissue repair
US8257963May 20, 2008Sep 4, 2012Depuy Mitek, Inc.Chondrocyte container and method of use
US8288444Jun 29, 2011Oct 16, 2012Codman & Shurtleff, Inc.Iontophoretic delivery of curcumin and curcumin analogs for the treatment of Alzheimer's disease
US8337537Jul 15, 2002Dec 25, 2012Depuy Products, Inc.Device from naturally occurring biologically derived materials
US8350093May 13, 2010Jan 8, 2013Codman & Shurtleff, Inc.Methylated curcumin-resveratrol hybrid molecules for treating cancer
US8354100Mar 23, 2011Jan 15, 2013Depuy Mitek, Inc.Chondrocyte therapeutic delivery system
US8383865Sep 30, 2009Feb 26, 2013Codman & Shurtleff, Inc.Curcumin derivatives
US8394369Aug 10, 2006Mar 12, 2013Depuy Mitek, Inc.Chondrocyte therapeutic delivery system
US8403988Sep 11, 2009Mar 26, 2013Depuy Spine, Inc.Minimally invasive intervertebral staple distraction devices
US8425517Jul 22, 2011Apr 23, 2013Depuy Mitek, Inc.Abrasive cutting system and method
US8435264Aug 30, 2010May 7, 2013Depuy Mitek, LlcKnotless suture anchor and driver
US8449561Feb 15, 2007May 28, 2013Depuy Mitek, LlcGraft fixation device combination
US8449584Dec 15, 2010May 28, 2013Depuy Mitek, LlcAbsorbable bone anchor
US8460340Aug 30, 2010Jun 11, 2013Depuy Mitek, LlcKnotless suture anchor
US8469998Aug 30, 2010Jun 25, 2013Depuy Mitek, LlcKnotless suture anchor
US8496970Feb 27, 2012Jul 30, 2013Depuy Mitek, LlcConformable tissue repair implant capable of injection delivery
US8507002Jul 25, 2008Aug 13, 2013Depuy Products, Inc.Hydrogel composition and methods for making the same
US8535350Sep 28, 2011Sep 17, 2013Depuy Mitek, LlcKnotless suture anchor
US8591579Dec 1, 2011Nov 26, 2013DePuy Synthes Products, LLCIntervertebral ligament having a helical bone fastener
US8592201Aug 6, 2012Nov 26, 2013Depuy Mitek, LlcChondrocyte container and method of use
US8609652Nov 30, 2010Dec 17, 2013DePuy Synthes Products, LLCMethod of administering a methylene blue-curcumin analog for the treatment of alzheimer's disease
US8623413Dec 7, 2007Jan 7, 2014Ethicon, Inc.Compositions and medical devices utilizing bioabsorbable liquid polymers
US8637066Sep 21, 2010Jan 28, 2014Depuy Mitek, LlcBiocompatible scaffold for ligament or tendon repair
US8641775Feb 1, 2011Feb 4, 2014Depuy Mitek, LlcViable tissue repair implants and methods of use
US8679159Aug 11, 2011Mar 25, 2014Depuy Mitek, LlcAnchor driver with suture clutch
US8685097Mar 4, 2013Apr 1, 2014DePuy Sunthes Products, LLC.Minimally invasive intervertebral staple distraction devices
US8691259Nov 16, 2005Apr 8, 2014Depuy Mitek, LlcReinforced foam implants with enhanced integrity for soft tissue repair and regeneration
US8709094Jun 26, 2006Apr 29, 2014DePuy Synthes Products, LLCAnti-adhesion sheet
US8734498Jun 24, 2010May 27, 2014DePuy Synthes Products, LLCIntranasal red light probe for treating alzheimer's disease
US8734517Feb 5, 2012May 27, 2014DePuy Synthes Products, LLPMedical procedure involving protective pad
US8790370Mar 30, 2012Jul 29, 2014Depuy Mitek, LlcSurgical filament assemblies
US20050232967Apr 20, 2004Oct 20, 2005Kladakis Stephanie MNonwoven tissue scaffold
EP0970711A2 *Jun 29, 1999Jan 12, 2000Ethicon, Inc.Process for coating stents
EP1223951A1 *Aug 15, 2000Jul 24, 2002Ethicon, Inc.Method of preventing adhesions with absorbable polyoxaesters
EP1604696A1Jun 26, 2002Dec 14, 2005Ethicon, Inc.Porous ceramic/porous polymer layered scaffolds for the repair and regeneration of tissue
EP1642595A1 *Sep 21, 2005Apr 5, 2006DePuy Products, Inc.Hydrogel composition comprising crosslinked polyethylene oxide and methods for production
EP1676535A1Dec 28, 2005Jul 5, 2006DePuy Mitek, Inc.Surgical abrasive cutting system
EP1967219A2Sep 26, 2007Sep 10, 2008Johnson & Johnson Regenerative Therapeutics, LLCTissue growth devices
EP1987850A1Dec 21, 2001Nov 5, 2008Ethicon, IncorporatedReinforced tissue implants and methods of manufacture and use
EP1994948A2 *Sep 21, 2005Nov 26, 2008DePuy Products, Inc.Method for producing hydrogel composition comprising crosslinked polyethylene oxide
EP2033648A2Apr 26, 2002Mar 11, 2009pSivida IncSustained release drug delivery system containing codrugs
EP2283845A1Apr 26, 2002Feb 16, 2011pSivida Inc.Sustained release drug delivery system containing codrugs
EP2325193A2Nov 4, 2002May 25, 2011Insert Therapeutics, Inc.Methods and compositions for therapeutic use of RNA interference
EP2422711A2Aug 26, 2011Feb 29, 2012DePuy Mitek, Inc.Knotless suture anchor
EP2422712A2Aug 26, 2011Feb 29, 2012DePuy Mitek, Inc.Knotless suture anchor
EP2422713A2Aug 26, 2011Feb 29, 2012DePuy Mitek, Inc.Knotless suture anchor and driver
EP2422714A2Aug 26, 2011Feb 29, 2012DePuy Mitek, Inc.Anchor driver with suture clutch
EP2422715A2Aug 26, 2011Feb 29, 2012DePuy Mitek, Inc.Suture anchor and threader
EP2574283A1Sep 28, 2012Apr 3, 2013DePuy Mitek, Inc.Knotless suture anchor
EP2574284A1Sep 28, 2012Apr 3, 2013DePuy Mitek, Inc.Knotless suture anchor
EP2749552A1Apr 17, 2008Jul 2, 2014Codman & Shurtleff, Inc.Curcumin-resveratrol hybrids
WO2010042049A1Oct 9, 2009Apr 15, 2010Milux Holding S.A.Composition, method and device for stabilizing implanted hydraulic devices
WO2010088469A2Jan 29, 2010Aug 5, 2010Ethicon, Inc.Collagen-related peptides and uses thereof and hemostatic foam substrates
WO2011061295A1Nov 19, 2010May 26, 2011Blue Medical Devices BvNarrow profile composition-releasing expandable medical balloon catheter
WO2012030754A1Aug 30, 2011Mar 8, 2012Depuy Mitek, Inc.Knotless suture anchor with unthreaded nose
WO2012088496A2Dec 23, 2011Jun 28, 2012Depuy Mitek, Inc.Adjustable anchor systems and methods
Classifications
U.S. Classification428/482, 525/444, 428/99, 442/43, 442/324, 428/98, 424/431, 424/432, 428/364, 424/426, 428/221, 424/448, 428/35.7, 424/447, 525/439, 424/444, 424/443, 424/446, 424/430, 525/438, 428/36.2, 525/437, 528/361, 428/361, 424/428, 528/363, 424/422, 442/123, 424/486, 424/433, 525/445
International ClassificationC08G63/685, A61L17/00, A61L15/64, A61K9/00, A61L27/00, C08L67/00, A61L29/04, A61L27/52, C08G63/66, A61L29/06, C09D167/00, A61L29/14, C08G69/40, A61K9/20, C08L101/00, C08G63/60, A61L27/18, A61L17/10, A61L31/14, C08G63/672, A61L15/22, C08L67/02, A61L31/04, C08G63/664, A61L15/26, C08G69/44, A61L31/06, A61L15/60
Cooperative ClassificationA61L31/06, C08L67/00, A61L15/225, C08G63/664, A61L29/145, A61L15/60, C08G69/44, C08L101/00, A61L29/049, A61L17/105, A61L27/18, A61L29/06, A61K9/204, A61L27/52, C08L67/025, C08G63/66, A61L15/26, C08G63/672, C08G69/40, A61L31/041, C09D167/00, C08G63/60, C08G63/6856, A61L31/145
European ClassificationA61L29/06, A61L31/04B, A61L15/26, A61L31/06, C08L67/02B, A61L29/04M, A61L27/18, A61L15/22M, C08L67/00, C09D167/00, C08G63/685D2, C08G69/40, A61L15/60, C08G63/60, A61L31/14F, C08G63/66, A61K9/20H6D4, C08G63/664, C08G69/44, A61L29/14F, C08G63/672, A61L27/52, A61L17/10B
Legal Events
DateCodeEventDescription
May 27, 2009FPAYFee payment
Year of fee payment: 12
May 31, 2005FPAYFee payment
Year of fee payment: 8
May 17, 2001FPAYFee payment
Year of fee payment: 4
Feb 19, 1997ASAssignment
Owner name: ETHICON, INC., NEW JERSEY
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:JAMIOLKOWSKI, DENNIS D.;BEZWADA, RAO S.;REEL/FRAME:008437/0469
Effective date: 19961111