|Publication number||US5752949 A|
|Application number||US 08/644,231|
|Publication date||May 19, 1998|
|Filing date||May 13, 1996|
|Priority date||Oct 29, 1991|
|Also published as||WO1997042849A1|
|Publication number||08644231, 644231, US 5752949 A, US 5752949A, US-A-5752949, US5752949 A, US5752949A|
|Inventors||Nikolai I. Tankovich, Zhong-Quan Zhao, Paul Fairchild|
|Original Assignee||Thermolase Corporation|
|Export Citation||BiBTeX, EndNote, RefMan|
|Patent Citations (34), Non-Patent Citations (4), Referenced by (131), Classifications (32), Legal Events (4)|
|External Links: USPTO, USPTO Assignment, Espacenet|
This application is a continuation in part of Ser. No. 08/489,358 filed Jun. 12, 1995, Ser. No. 08/492,283 filed Jun. 19, 1995 and Ser. No. 08/280,928 filed Jun. 26, 1994 now abandoned, all of which are continuations in part of Ser. No. 005,810 filed Jan. 1, 1995 now U.S. Pat. No. 5,425,728, issued Jun. 20, 1995 which was a CIP of Ser. No. 07/783,789 filed Oct. 29, 1991 now U.S. Pat. No. 5,226,907 issued Jul. 13, 1993. The entire disclosures of U.S. Pat. Nos. 5,425,728 and 5,226,907 are incorporated herein by reference to them.
This invention relates to devices and methods for hair removal and in particular to the use of laser devices for hair removal and long-term prevention of hair growth.
The principal methods presently used to attempt permanent hair removal involve the use of electrolysis techniques. These techniques involve some pain, are time consuming, and demand a fair degree of expertise in their application and normally do not guarantee a permanent effect.
The prior art of hair removal also includes attempts at removing hair with laser beams. Three such techniques are described in the following United States patents: Weissman et. al., Method for Laser Depilation Device and Method, U.S. Pat. No. 4,388,924; Sutton, Depilation Device and Method, U.S. Pat. No. 4,617,926; and Mayer, Depilation by Means of Laser Energy, U.S. Pat. No. 3,538,919. All of these devices and methods teach the removal of hairs one hair at a time with a narrowly focused laser beam. Therefore, they are relatively inefficient and time consuming. A more recent patent by Zaias, U.S. Pat. No. 5,059,192 issued Oct. 22, 1991 discloses a process for using a laser beam matched to the melanin found at the base of the hair follicle and papilla.
What is needed is an improved hair removal process.
The present invention provides a process for the long term or permanent removal and prevention of growth of unwanted hair. The upper portions of hair ducts (i.e. portions near the skin surface) in a section of skin are contaminated with a contaminant having a high absorption at at least one frequency band of light. The skin is then illuminated with light at the frequency band of high absorption by the contaminant using an illumination process having at least two distinct phases.
In the first of these phases, called the "explosion" or "mechanical" phase, the skin section is illuminated with at least one short pulse of light at sufficiently high power so as to impart sufficient energy in a sufficiently short time period to the contaminant located in upper portions of the hair ducts to cause tiny explosions in the contaminant, forcing portions of the contaminant more deeply into the hair ducts. During the second phase, called the "cooking" or "thermal" phase, the skin section is illuminated with light at a frequency band of high absorption in the contaminant but in a manner chosen to heat the contaminant to a high temperature without substantial explosion or vaporization of the contaminant. The hot contaminant then heats portions of the skin tissue immediately surrounding the contaminant to a temperature high enough and for a long enough period of time to devitalize (kill) the tissue. The process may include a third phase, called the "cleanup" phase, during which the skin section is illuminated with short pulses of light at sufficiently high power so as to impart to the contaminant sufficient energy in sufficiently short time periods to cause additional tiny explosions in and vaporization of portions of the contaminant then remaining in the ducts and additional damage to the skin tissue immediately surrounding the contaminant.
In a preferred embodiment, initially at least some of the hair in the section of skin being treated is removed by waxing so as to allow more space in the hair ducts for infiltration of contaminant. Then the contaminant, such as a mixture of 1 micron graphite particles in mineral oil is applied to the skin surface and massaged to cause some of the contaminant to infiltrate into the hair ducts. During the first phase of illumination, the explosion phase, the skin section is illuminated by a few pulses of a short pulse duration laser beam; e.g., from one to about three Nd:YAG laser pulses at 1.06 micron wavelength, each pulse having an energy density of about 2 Joules per square centimeter (J/cm2) and a pulse duration of about 10 nanoseconds (ns). The photons in this laser beam are scattered greatly by skin tissue but the absorption coefficient of the photons in skin tissue is relatively very small. We estimate that the absorption coefficient for the Nd:YAG photon in the graphite particles is at least several thousand times greater than the absorption coefficient of skin tissue; therefore, substantially all photons encountering a graphite particles in the course of their travel through the skin will be absorbed, the 1 micron carbon particles capturing photons like little "black holes." Because of the high absorption in the graphite particle, the particles are heated very rapidly by one pulse and the pulse duration is so short that very little heat is conducted out of the particle during the pulse. The power density of these pulses is about 200 Megawatts/cm2, enough to heat the particles to their vaporization temperature of about 3,600 degrees C., causing an explosion of the particles and vaporizing a portion (estimated to be about 10 to 30 percent) of the particles. These explosions cause most of the particles on the skin surface to be blown off the skin surface and force many of the particles near the top of the hair ducts deeply into the hair ducts.
During the second illumination phase, the cooking phase, each portion of the skin section is illuminated with 1.06-micron laser light at an energy density of about 2 J/cm2 but with a pulse width of about 100 microseconds. The power density of these pulses is only about 20 Kilowatts/cm2. These pulses impart about the same amount of energy to the graphite particles as the short 10-nanosecond pulses but at a very much slower rate. The particles in turn transfer energy by conduction to the surrounding tissue and oil during the pulse so that the vaporization temperature of the particle is in most cases not reached and there is no significant vaporization or explosion of the particles. In this embodiment the pulses are applied at a 10 Hz rate, but the skin is slowly scanned so that each section is illuminated for only about two to three seconds (about 25 pulses or 50 J/cm2 per scan). The illumination heats up the skin generally (like sunlight or an infrared lamp) in addition to the carbon particles, but the general heating of the skin is at a much slower rate. Thus a scan of a skin section is limited to no more than about 30 pulses and between scans the skin section is allowed to cool. The scan may be repeated as many times as desired because there is no diminution of the quantity of graphite during this phase.
During the third phase of a preferred illumination process, the clean up phase, the skin section is illuminated with about 10 Nd:YAG laser pulses at 1.06 micron wavelength and 10 Hz, each pulse having an energy density as in the first phase of about 2 J/cm2 and a pulse width of about 10 nanoseconds. Again, the pulse duration is so short that very little heat is conducted out of the particle during the pulse. As before, the power density of these pulses is about 200 Megawatts/cm2, enough to heat the particles to over 3,600 degrees C., cause explosions of the particles and vaporize with each pulse a portion (estimated to be about 10 to 30 percent) of the particles. These explosions cause additional damage to the tissue surrounding the particles and further fragment and distribute the particles in the hair ducts. Also, after about one second of illumination (about 10 pulses) the particles are mostly vaporized or broken into fragments so small that they are invisible to the unaided eye.
In another preferred embodiment, the second phase illumination consists of about 2,000 pulses at 0.2 J/cm2 with a pulse duration of 10 nanoseconds. This requires about 200 seconds per skin section but the cross section of the laser beam can be expanded by a factor of ten and the illumination scan time can be increased from about 3 seconds to about 12 seconds or longer without significant risk of general skin burning. At a pulse energy density of illumination of 0.2 J/cm2 the particles are heated to temperatures in the range of about 1,000 degrees C.
FIG. 1 is a drawing of a section of human skin showing a growing hair.
FIGS. 2A, B, C and D show a cross section of skin and 3 hairs during 4 stages of a process of one embodiment of the present invention.
FIGS. 3A and 3B shows qualitatively the paths of the photons of a laser pulse showing absorption in a carbon-oil suspension.
FIG. 4 A through C shows an experiment with turkey skin, egg white, a partially contaminated hair and a laser beam to demonstrate some of the elements of the present invention.
FIGS. 5A and 5B show another experimental set up to demonstrate elements of the present invention.
FIG. 6 illustrates a preferred embodiment with fluid providing a photon pathway through hair ducts to the papilla region.
A section of human skin showing a cross section of one hair is shown in FIG. 1. The FIG. 1 drawing shows a hair shaft 33, a hair duct 31, a nerve ending 34, a sweat gland 35, a sebaceous gland 38 and arteries 36, veins 37, and papilla 32.
In the graphite form of elementary carbon, each carbon atom has three near neighbors and a fourth neighbor at a considerably greater distance away, the two lengths being 1.42 Å and 3.42 Å, respectively. (10,000 Angstroms equal 1 micron.) The network of the three nearest neighbors is planar and extends in the two directions of the plane to the boundaries of the solid. The binding forces between the planes are weak and the planes can slip past each other very readily. For this reason, graphite can be used as a lubricating material. Thin layers of graphite can be removed by abrasion and this property is exploited in the ordinary lead pencil in which motion of the graphite rod over paper causes thin layers of the solid to be rubbed off and spread on the paper. For many years laser workers have used paper thinly coated with small particles of graphite to examine the cross section power of certain laser beams. The energy of many laser beams is readily absorbed by the carbon particles and many of the particles react violently, exploding off the paper and leaving "footprints" on the paper representative of the cross sectional power distribution of the laser beam.
A laser beam absorbing carbon suspension is prepared consisting of graphite powder in mineral oil. The particle size of the powder is preferably about 1 micron and its concentration preferably is about 20 percent by mass. This suspension is used to contaminate the hair ducts, so the suspension is sometimes referred to herein as the "contaminant." The expression "contaminant" is also used to refer to the particles of the suspension, as is apparent from the context.
A section of skin with growing hairs is depicted in FIG. 2A. To prepare the skin section for the process of the invention, the skin is preferably washed with soap and water then rinsed with water and dried with a cloth towel. The skin section is then cleaned, as with methyl alcohol, and allowed to dry.
The next step in this preferred embodiment is to physically remove the hair shafts from the hair ducts in the skin section to be treated. Preferably this is accomplished using a well known temporary hair removal procedure known as waxing. A suitable wax is the commercially available wax marketed by Select Spa Source of Sausilito, Calif. under the trade name Nature's Own Pine Wax although a wide variety of such waxes are available and would be satisfactory. The hair is removed by following the waxing procedure furnished with the wax.
Removal of the hair from the hair ducts greatly increases the space available in the hair duct for the graphite-oil contaminant, permitting a much greater quantity of the contaminant to be infiltrated into the hair duct. FIG. 2B shows the same three hair ducts as FIG. 2A with the hair shafts removed.
The next step is to apply the graphite-oil contaminant referred to above to the section of skin to be treated. The contaminant is applied to the skin in quantities of about one gram per 10 square centimeters, although the exact amount is not critical. The contaminant is massaged thoroughly on the skin surface for a period of about 1 minute for each 10 square centimeters of skin surface. The principal objective in this step is to cause as much of the graphite particles as feasible to infiltrate into the hair ducts in the skin section. Tests indicate that the graphite oil contaminant can be infiltrated with this massage technique into the hair duct to a depth of about 0.5 mm. For a 100 micron diameter hair duct, this would correspond to about 700,000 carbon particles in the duct. There is great variation in the amount of graphite infiltrated but for purposes of illustration an infiltration of 700,000 one micron particles (about 1.4×10-6 grams of carbon particles may be assumed.) At the conclusion of the massaging step, the contaminant is present in the upper part of the hair duct, and the skin surface is substantially covered with graphite-oil contaminant as shown in FIG. 2C.
As indicated above, the present invention includes at least two distinct phases of illumination with the objective of achieving maximum hair destruction with minimal damage to skin tissue. In a preferred process the illumination is provided by a Nd:YAG pulsed laser operating at a wavelength of 1.06 microns with a beam cross sectional area of about 0.5 cm2. Controls on the laser permit selection of short pulses of 10 ns duration using a Q switch and a long pulse duration of about 100 microseconds (100,000 ns), with the Q switch disconnected. (The pulse duration is approximately the interval of time over which the pulses are at at least one half maximum power.) Pulse energy can be adjusted to between about 0.1 J and 1.25 J, corresponding to 0.2 J/cm2 and 2.5 J/cm2 for the 0.5 cm2 beam.
As stated above, the first phase of the illumination process is referred to as the "explosion" phase. The laser is adjusted to produce 1 Joule per pulse which is equivalent to about 2 J/cm2 since the beam cross section is about 0.5 cm2. The pulse duration is 10 ns and the repetition rate is 10 Hz. Each portion of the skin section to be treated is illuminated with about two to three pulses. This is done by scanning the 0.5 cm2 10 Hz beam over the skin surface at the rate of about 2 cm/s.
Each pulse contains about 1×1019 photons. The 1 micron graphite particles are very highly absorptive of the 1.06-micron laser photons. The absorption coefficient of graphite is estimated to be between several thousand to about 100 thousand times greater than the absorption coefficient for typical skin tissue. The penetration depth for 1.06 micron photons in graphite is substantially less than 1 micron so substantially all photons encountering a particle are absorbed by it. The 1.06-micron photons are well scattered by skin tissue. The scatter coefficient for dermal tissue is estimated to be about 100 cm-1 whereas the absorption coefficient is estimated to be about 0.33 cm-1. Therefore, the length of the path traveled by photons between scatters is estimated to be about 100 microns and the path traveled in the dermis before absorption in the dermal tissue is estimated to be 3 cm. The result of the large scattering is that the 1.06-micron photon flux builds up and is actually greater (by a factor of about 5) just below the surface of the skin than the incident flux on the surface of the skin. At two to three mm below the surface (about the depth of most hair roots) the flux has decreased but is still about equal to or maybe a little less than the incident flux. Almost all of the photons entering the skin surface are ultimately absorbed in the carbon or absorbed in the skin tissue.
The cross sectional area of a 1 micron particle is roughly 1×10-8 cm2 so the energy absorbed by a typical particle out of a 2 J/cm2 flux is in the range of about 2×10-8 J. This is a very small amount of energy but the particle is also very small (with a volume of about 1×10-12 cm3). Its density is about 2 gm/cm3 and its average specific heat is about 2 J/gmC over the temperature range from ambient up to its vaporization temperature. Therefore, each pulse pumps enough energy into the graphite particle to raise its temperature by approximately: ##EQU1##
However, graphite vaporizes at about 3,600° C. Thus, only a portion of the energy absorbed by the particle is used to heat it from 27° C. (normal skin temperature) to its vaporization temperature. The remainder of the absorbed energy is released in a miniature violent explosion of the particle in which a portion of the particle is vaporized and the particle is broken into smaller particles which recoil away from the explosion site. The explosion also creates a shock or pressure wave which pushes other particles away from the explosion site. The heat capacity of carbon averages about 2 J/gm°C. over the range 0 to 3,600° C. The heat content to raise the temperature of graphite to the vaporization point is then about 7,200 J/gm. Thus, in the above example (7,200 J/gm)×(2×10-12 gm)=1.4×10-8 J of the absorbed laser energy is used to raise the temperature to the vaporization level. The remaining 0.6×10-8 J absorbed causes the vaporization of a portion of the graphite particles. The heat of vaporization of carbon is about 6×104 J/gm; therefore, the energy needed to vaporize all of the 1 micron (2×10-12 gm) particle is about 12×10-8 J. Hence, in this illustration only about 5 percent of the particle is vaporized with each pulse.
One effect of the miniature violent explosions is to blow essentially all of the particles off the surface of the skin. Also, some of the particles and portions of particles in the upper parts of the hair ducts are blown out of the hair ducts. Most of the particles in the upper portion of the hair ducts, however, are shielded to some extent by particles surrounding them and are forced further down the ducts by the explosion of particles near the top of the ducts. FIG. 2D shows some typical distribution of graphite particles in the ducts after the conclusion of the explosion phase. If it is assumed that the quantity of graphite in the typical duct is roughly 1.4×10-6 gm (700,000 particles) and at an average of 2×10-8 J is absorbed per particle per pulse, then the energy absorbed in a hair duct is about 14×10-3 J/pulse. This is equivalent to the amount of energy needed to increase the temperature of a cylinder of water 3 mm long and about 67 microns in diameter by 80 degrees C. The estimate would be much higher if greater quantities of particles were present and if flux buildup near the skin surface were taken into account. Skin tissue has a specific heat which is about the same as water. From this illustration it is expected that some damage occurs to skin tissues within a few microns of the upper part of the hair duct during the explosion phase but probably not enough to devitalize the hair. Also, some damage may result from the shockwaves or pressure waves. However, the main advantage of the explosion phase is that particles are forced down the duct to the region of the duct near the papilla through which growing hair receives its nourishment. The explosion phase also clears substantially all particles off the surface of the skin.
The second phase of the illumination phase is referred to as the "cooking" or "thermal" phase because the objective of this phase is to heat the skin tissue adjacent to the hair duct to a temperature high enough to permanently devitalize (kill) it, so that the tissue cannot support future hair regrowth. Prior to starting this phase, graphite particles remaining on the skin surface are cleaned off as completely as feasible with a cloth soaked in mineral oil. This also tends to fill in void spaces in the hair duct (especially at the top of the duct) with mineral oil, which transmits 1.06 microns light very well. During the cooking phase a volume within about 150 microns radius of the center of the hair duct is targeted, and heating is done primarily by applying heat from laser illumination to the graphite particles which are now distributed deeply in the hair duct. Laser photons absorbed in the graphite particles include photons scattered into the hair duct from the surrounding skin tissue and also photons transmitted down the hair duct through mineral oil which now fills the upper part of the duct. Heat is transferred by conduction from the graphite to the surrounding tissue. During the "cooking" phase heat energy is applied slowly enough so that substantial vaporization or fracturing of the graphite is avoided, and thus heat may be applied to the tissue via the graphite particles a very large number of times. In one preferred embodiment, for the cooking phase, the Q switch is disconnected so that the laser produces pulses of about 100 microseconds duration. Energy density may be 2 J/cm2 and the repetition rate set at 10 Hz.
The skin is scanned so that each portion of the section of the skin being treated is illuminated for only about 2.5 seconds (about 25 pulses) before being allowed to cool down e.g., for about 60 seconds. Each pulse, in addition to heating the graphite, applies heat generally to the skin tissue and increases the temperature of the skin tissue about 0.5 to 1.5 degrees C., so more than 30 pulses could cause the skin portion being illuminated to become very warm. Experiments have indicated that burning pain is experienced after five to seven seconds of 2 J/cm2 10 Hz pulses (100 to 140 Joules/cm2); therefore, the number of laser pulses between "cool down" periods is preferably limited to well below this threshold.
Each portion of the skin section being treated receives about 20 scans for a total of about 500 pulses. (This takes a total of about 50 seconds per portion.) Each 1 micron particle absorbs very roughly about 2×10-8 joules per pulse or about 50×10-8 joules per 2.5 second scan. Heat diffuses out from the graphite particles to a distance of about a few tens of microns during the first few milliseconds after the start of a scan and diffuses a few hundred microns in one second. If it is assumed that the equivalent of 500,000 one micron cubic particles are present per duct, each duct would receive roughly about 0.25 Joule per each 2.5 second scan. This 0.25 Joule would be sufficient to increase the temperature of a volume of water 3 mm long and 563 microns diameter by 80 degrees C. The specific heat of skin tissue is about the same as that of water. Skin tissue is devitalized (killed) if kept at a temperature of 70 degrees C. for about 1 second. Skin tissue closest to the carbon particles will be heated to temperatures much higher than 70° C. It is estimated that skin tissue within about 1 to 3 hair diameters of the hair ducts is devitalized during this phase. Actual biopsy studies of both pig and human skin confirm these estimates.
Preferably during a third phase of the illumination process, which is referred to as the "clean up" phase, the skin section is illuminated with about ten Nd:YAG laser pulses at 1.06 micron wavelength and 10 Hz, each pulse having an energy density as in the first phase of about 2 Joules/cm2 and a pulse width of about 10 nanoseconds. Again, the pulse duration is so quick that very little heat is conducted out of the particles during the pulse. As before, the power density of these pulses is about 200 Megawatts/cm2, enough to heat the particles to over 3,600 degrees C., cause explosions of the particles, and vaporize with each pulse a portion (about 5 percent) of the particles. These explosions cause additional damage to the tissue surrounding the particles. Also, after about 10 to 30 pulses, the particles are mostly vaporized or broken into particles so small that they are invisible to the unaided eye.
In order to confirm the above description, experiments were conducted in which these small carbon particles were irradiated with pulses of the type described above.
A small number (about 0.1 gm) of one micron size graphite particles were placed in an enclosed glass vial in an air atmosphere and irradiated with pulses as described above under the "Explosion Phases" with no scanning. The particles were continuously broken into smaller and smaller particles and after about 10-15 pulses they vanished. It is believed that the very small particles were oxidized to form CO or CO2. When the same experiment was conducted in an argon atmosphere the particles continued to break into smaller and smaller parts until they were nearly invisible to the unaided eye (i.e. about 0.1 micron to 0.05 micron).
Laboratory experiments were also conducted to demonstrate the effectiveness of the explosion phase and the cooking of the preferred process. In one experiment carbon-oil contaminant was infiltrated into the top of a 100 micron inside diameter, 5 mm long fiber optic tube to a depth of about 1 mm. The bottom of the tube was blocked and the top of the tube was irradiated with one 10 ns pulse from a 1.06 micron wavelength Nd:YAG laser at 2 J/cm2. As a result of miniature particle explosions at the top of the tube, graphite particles were distributed throughout the tube with maximum concentration of particles at the bottom of the tube. The tube with 100 microsecond 2 J/cm2 pulses for five seconds. The heat absorbed by the carbon caused the inner surface of the tube and tube's fiber clad to deform. A tube without graphite was illuminated with 2 J/cm2 for 25 seconds with no visible effect on the tube. In another test of a tube with graphite in it and illumination at 3 J/cm2 for five seconds, the tube melted.
In other experiments the preferred process was tested with pig skin in vitro. In one experiment to examine the explosion phase of the preferred illumination process, hairs in sections of the pig skin was removed prior to the topical application of the contaminant and in other skin sections the hair were not removed. After the topical application of the contaminant, the skin sections were illuminated with 1, 2, 5 and 10 pulses (all at 10 ns duration) at power levels of 1 J/cm2, 2 J/cm2 and 3 J/cm2. The skin was then biopsied to permit examination of the follicles. The maximum and deepest contamination was produced with 2 pulses at 2 J/cm2. At 3 J/cm2 vaporization of the carbon became substantial. In those sections where the hair was removed the graphite particles completely filled the hair ducts with heavy concentration at the bottom of the duct. In those sections where the hair was not removed, the graphite particles were distributed deeply into the duct, but generally very few particles reached the bottom of the ducts.
FIGS. 4A, 4B and 4C are sketches illustrating an experiment performed in order to demonstrate elements of this hair removal process. Three layers of turkey drumstick skin 10 were sandwiched between two glass microscopic slides 8. The thickness of the 3 layers of turkey skin was about 2 millimeters (approximate depth below the skin surface of the bottom of human hairs). A single human hair 16 about 10 cm long was coated over a 3 cm section with a mixture 18 of 1 micron particles of carbon (graphite) and mineral oil (about equal mass). The hair was immersed in chicken egg white 14 contained in a small (5 cm diameter) vial 12. The drawing is roughly to scale except the diameter of the hair and the carbon-oil contaminant is exaggerated.
The hair including the coated section was illuminated with 100 pulses of laser radiation from a Nd:YAG laser.
The following is a description of the pulsed laser beam:
______________________________________Wavelength 1.06 micronEnergy per pulse 1.5 JoulesBeam area 1/2 cm2Energy density 3 J/cm2Frequency 10 pulses per secondPulse duration 10 ns______________________________________
Each pulse 20 passed through the slides and turkey skin with no apparent effect on the skin. The beam also passed through the wall of the vial and through the egg white.
The beam was scanned over the hair so that each portion of the hair received about 5 pulses. The beam had no effect on the hair or the egg white except near the section of the hair which was coated. In that section, the carbon in the mixture absorbed sufficient energy from the beam to cook the egg white immediately surrounding the coated section of the hair. In this experiment the cooking process could be readily observed because uncooked egg white is transparent.
FIG. 4B shows the result of the first 10 pulses of beam 20 (about 3 pulses into the carbon) passing through the elements of this experiment. The only discernible effect of these pulses was an obvious heating and cooking of the egg white immediately adjacent to the coated section of the hair. Some fragments, of carbon particles were thrown off the hair but were trapped in the immediate surrounding egg white. These fragments were further fragmented by subsequent pulses into very small fragments or oxidized. FIG. 4C shows the results of 100 pulses. The egg white tissue in the immediate vicinity of the coated section was cooked to a thickness of about 500 microns. There was no damage discernible in either the turkey skin or anywhere else in the egg white or to the hair itself other than the coated section. These conclusions apparent to the unaided eye were checked and confirmed under a microscope. Only a very few small particles of carbon remained.
FIG. 5A shows a drawing of another egg white experiment conducted to test the cooking phase. Two layers of chicken skin 50 were placed at the bottom of a glass dish 52. Separate ends of a human hair 54 was glued with super glue to paper clips 56 and the portion of the hairs between the clips were coated with a preferred graphite-oil contaminant 58 (about equal mass of mineral oil and 1 micron graphite particles). The hair-paper clip assembly was placed on the chicken skin and the hair, paper clips and skin were covered with egg white. The hair was then illuminated from below through the chicken skin and the egg white with 100 microsecond laser pulses 60 at 2 J/cm2 at the rate of 10 Hz for about 2 to 3 seconds. This process was repeated several times allowing for cooling between illuminations. With this setup, the experimenter could watch the hot graphite cook the adjacent egg white, and the hair, particles and egg white could be viewed periodically with a microscope. Egg white immediately surrounding the contaminant coated hair was cooked with no damage to the skin or any egg white not close to the contaminant. Also, after many repeat illumination periods of about 2.5 seconds (during which about 50 J/cm2 was delivered), there was no detectable diminution of the carbon particles. Therefore, it was concluded that the "cooking" process (with in-between cooling periods) could have continued indefinitely with no apparent damage to the skin or egg white except the egg white in the immediate vicinity of the contaminant.
The above experiment was also conducted as described above but with pulses at 0.2 J/cm2 with the Q switch in place so that the pulse was 10 ns and 0.2 J/cm2. There was cooking of the egg white adjacent to the graphite but no violent explosion or obvious fragmentation of carbon particles. And at the conclusion of a large number of pulses there was no substantial diminution of the graphite particles. (At 0.2 J/cm2 about 250 pulses could be applied before general skin heating would become a problem, and a pulse frequency to 50 or 100 Hz is recommended.) A rough estimate the temperature rise in the carbon particles is obtained as follows: ##EQU2##
This is based on an estimated particle cross section of 1×10-8 cm2, mass of 2×10-12 gm and a specific heat of about 1 J/gm°C. in the temperature range between ambient and 1,000° C.
These experiments show that, when illuminated with 10 ns pulses and 2 J/cm2 energy, carbon particles explode violently (on a miniature scale) and are partially vaporized. However, increasing the pulse duration to 100 microseconds (with pulse energy at 2 J/cm2) or reducing the energy to about 0.2 J/cm2 (with a 10 ns pulse) permits delivery of sufficient heat to the carbon to cook tissue with no substantial vaporization or explosion of the carbon. This permits the "cooking" phase to be continued indefinitely.
Another potential method of increasing the quantity of contaminant in the hair duct is to use very small spherical particles. A carbon molecule meeting these specification has recently been produced and is available commercially. These molecules are known as "Buckey balls" or C60. Buckey balls are carbon molecules, roughly spherical, each consisting of 60 atoms of carbon. Buckey balls are commercially available, (e.g., under the name Buckminsterfullerene from Sigma Chemical Company of St. Louis, Mo.) at prices of about $300 per gram. An initial experiment with this form of carbon contaminant indicates very potentially promising results. The Buckey balls are very absorptive of Nd:YAG laser beams and appear to infiltrate into hair ducts very readily.
The explosives and/or cleanup phases of the various embodiments of this invention could be enhanced by utilizing a contaminant that will chemically react exothermically upon absorption of the short pulses of light. For example, small quantities of a mixture of 75% potassium nitrate (KNO3) 15% carbon (c) and 75% sulfur (s), commonly known as black powder, explodes violently when illuminated with the 2 J/cm2 Nd:YAG laser pulse. The energy released (in the form of heat and mechanical energy) is estimated to be 10 to 30 times that released from an equal quantity of graphite powder illuminated with the same laser beam. The black powder can be provided in powder form with sizes small enough to infiltrate the hair ducts and the powder can (like the graphite powder) can be mixed with mineral oil for topical application to the skin.
Black powder or another absorptive/chemically reactive material may also be used as part of the contaminant initially applied to the skin--i.e., such contaminant may be a mixture of black powder and the graphite/oil suspension described herein. Explosions of the black powder of this contaminant (and of portions of the graphite) during the explosion phase may help force the remaining graphite to the bottom of the hair ducts, with such remaining graphite then being available for absorption of laser energy and heating of tissue during the cooking phase.
There are a vast number of other well known explosive materials which release energy exothermically and can be ignited with short pulses of light which penetrate skin tissue.
Another preferred method of increasing the quantity of contaminant in hair ducts is to repeat the topical application and explosion phase one or more times. Experiments have indicated that the explosion phase opens the ducts slightly wider providing more room for contaminant on the second application. Increasing the quantity of graphite in a duct increases the amount of heat which can be imported to the duct during the cooking phase. Steps in one variation of this method would include the following steps:
2. first topical application of contaminant
3. first explosion phase
4. first cooking phase
5. second topical application
6. second explosion phase
7. second cooking phase
8. clean up phase
For difficult hair removal cases steps 5, 6, and 7 could be repeated several times. On each repetition, additional graphite would accumulate in the hair duct, permitting more and more heat to be imported during the cooking phase. Another approach is the same steps as listed above with the first cooking phase (step 4) omitted. The cleanup phase removes substantially all graphite from the duct or fractures it into particles of very small sizes.
In another preferred embodiment of the present invention, graphite particles are deposited in the hair duct as close to the papilla as possible and the remainder of the hair duct is filled with mineral oil. A cooking phase is then used to provide maximum preferential heating of tissue in the papilla region of the hair duct. Steps in one variation of this method would include the following:
2. topical application of contaminant
3. first explosion phase
4. clean skin surface with mineral oil
5. apply mineral oil to skin surface and massage into ducts
6. cooking phase
7. clean up phase
Experiments conducted on mineral oil indicate that such oil, which is transparent to the 1.06 micron light and has an index of refraction substantially greater than that for skin, will conduct light beams down the hair duct to the papilla area. Absorbers in the papilla region would then receive illumination both from photons scattered from the dermis and photons traveling through the mineral oil in the upper region of the hair duct. This effect is illustrated in FIG. 6, which shows the paths of five typical photons A, B, C, D and E. A and B are scattered many times in the dermis and are ultimately absorbed in graphite particles 70 in the bottom of the hair duct 31. Photon C travels down the hair duct through the mineral oil 72 similar to photons in an optical fiber and also is absorbed in graphite particles at the bottom of the hair duct. Photons D and E are depicted as being absorbed in skin tissue.
Another approach would consist of the following steps:
2. topical application of lotion
3. first explosion phase
4. clean skin surface with mineral oil
5. apply mineral oil to skin surface and massage into ducts
6. first cooking phase
7. second explosion phase
8. repeat step 5
9. second cooking phase
10. clean up phase
Steps 6 and 7 help clean out and open up the upper portions of the hair duct to permit a cleaner and wider passage for photons through the mineral oil in the hair duct.
Persons skilled in the laser-medicine art will recognize that many other light source-contaminant combinations could be used to practice this invention. The important attributes of the combinations are:
1) The light source must penetrate skin tissue, at least for the cooking phase.
2) The contaminant should be capable of being infiltrated in significant quantities into the hair ducts.
3) The contaminant must be very highly absorptive of energy at the wavelength of the beam and capable of being forced deeper into the hair ducts (as by explosion) upon illumination with short high power pulses.
4) The process includes at least two distinct phases: a) an explosion phase to distribute the particles in the hair ducts and b) a cooking step during which heat energy is applied via the contaminant without substantial fragmentation or vaporization of the contaminant.
In addition, a clean up phase is highly desirable in which contaminant remaining in the duct after the cooking phase is vaporized by short pulses of light.
Preferably the contaminant (e.g., graphite) vaporizes at a very high temperature and during the illumination period of the explosion phase absorbs enough energy to partially vaporize. These circumstances permit the contaminant to transfer high temperature heat to skin tissue and also to provide an explosive force to distribute light absorbing contaminant to the bottom of the hair duct. Ultimate vaporization and breaking into small parts of the contaminant during the clean up phase also serves the useful function of removing most of the contaminant from the duct during the treatment process. Fracturing the contaminant into ever smaller particles is also a satisfactory process of effectively removing the particles. This is because small particles become invisible after a few fractures and once they are reduced to a small fraction of a micron the body's immune system can remove them.
Although particle size is not critical, the particles must be small enough to infiltrate the hair ducts and they should be large enough to absorb the photons. Preferred sizes are preferably in the range of 0.5 microns to about 5 microns.
With illumination that penetrates skin tissue about 0.5 cm, no more than about 60 J/cm2 can be added without general overheating of the skin tissue unless a portion of the heat is dissipated. This overheating can be avoided by applying the heat in increments allowing the skin to cool naturally between illuminations. Another approach is to artificially cool the surface of the skin either prior or during the illumination or both prior to and during the illumination. Tests have been using cold air, ice and canned nitrogen to cool the surface of the skin. However, use of topical cooling is recommended only when natural cooling is not effective since cooling the surface of the skin may interfere with nerve sensors in the skin which provide a natural alarm function to prevent unintended damage to the skin.
Many contaminants other than graphite particles in mineral oil may be used. Tests have been conducted using acrylic tattoo inks which have been approved by the FDA for tattoo use. Black and blue tattoo inks marketed by Spaulding and Rogers appear to work well with a Nd:YAG laser operating at 1 Hz, 1.06 micron with an energy density of about 3 J/cm2. Less success has been achieved with inks of other colors.
It is not necessary to remove the hairs prior to illumination. FIG. 3B depicts an illumination phase with the hair shaft remaining in the duct as compared to FIG. 3A where the hair has been removed. The three preferred illumination phases are as described above. The results are usually not as good with the hair in place during the process since the quantity of graphite which can be loaded into the duct is greatly reduced.
Pulse durations other than those described above may be used. For example, preliminary tests have been performed with 2 ns pulses for the explosion phase. These pulses appear to provide greater explosions but it may be necessary to reduce the energy per pulse to avoid general damage to skin tissue.
We have discovered that better transmission through the skin can be achieved by stretching the skin. This also helps keep the ducts open which is important when utilizing the embodiment in which photons are transmitted down the hair duct through mineral oil. Pressing the skin can reduce the distance between the skin surface and the hair root and may thereby result in more photons being absorbed in the lower regions of the duct.
Illumination during the cooking phase can be effected by any of a wide variety of illumination sources, and with different pulses, from very short nanosecond pulses to much longer pulses, or even a continuous beam for periods of a few seconds. The objective is to impart as much energy as feasible to the graphite particles without causing general overheating of skin tissue. The laser could be controlled with a microprocessor to automatically provide a Q-switched beam, then a non-Q-switched beam followed by a Q-switched beam. Such a system could be useful in conjunction with automated scanning.
Another embodiment of this invention is to utilize for the cooking phase a laser pulse which vaporizes a very small percentage (such as 1%) of the graphite in the duct with each pulse. This would permit several hundred pulses before the quantity of graphite is reduced to the point of ineffectiveness. At that point a few 2 J/cm2 pulses could be applied to vaporize most of the remainder.
The above-described methods are exemplifications of preferred embodiments of the inventions and many other possible variations are within its scope. The invention is to be measured by the appended claims and their legal equivalents, and not limited to or by the examples which have been given.
|Cited Patent||Filing date||Publication date||Applicant||Title|
|US3538919 *||Apr 7, 1967||Nov 10, 1970||Gregory System Inc||Depilation by means of laser energy|
|US3693623 *||Dec 25, 1970||Sep 26, 1972||Gregory System Inc||Photocoagulation means and method for depilation|
|US3769963 *||Mar 31, 1972||Nov 6, 1973||L Goldman||Instrument for performing laser micro-surgery and diagnostic transillumination of living human tissue|
|US3794028 *||Feb 27, 1973||Feb 26, 1974||Griffin A||Method for injecting chemicals into the papilla for depilation|
|US3834391 *||Jan 19, 1973||Sep 10, 1974||Block Carol Ltd||Method and apparatus for photoepilation|
|US3900034 *||Apr 10, 1974||Aug 19, 1975||Us Energy||Photochemical stimulation of nerves|
|US4336809 *||Mar 17, 1980||Jun 29, 1982||Burleigh Instruments, Inc.||Human and animal tissue photoradiation system and method|
|US4388924 *||May 21, 1981||Jun 21, 1983||Weissman Howard R||Method for laser depilation|
|US4461294 *||Jan 20, 1982||Jul 24, 1984||Baron Neville A||Apparatus and process for recurving the cornea of an eye|
|US4608978 *||Sep 26, 1983||Sep 2, 1986||Carol Block Limited||Method and apparatus for photoepiltion|
|US4617926 *||Jan 30, 1984||Oct 21, 1986||Sutton A Gunilla||Depilation device and method|
|US4712543 *||Jul 23, 1984||Dec 15, 1987||Baron Neville A||Process for recurving the cornea of an eye|
|US4813412 *||Dec 27, 1983||Mar 21, 1989||Ya-Man Ltd.||Automatic system for an epilator device|
|US5059192 *||Apr 24, 1990||Oct 22, 1991||Nardo Zaias||Method of hair depilation|
|US5423803 *||Jun 8, 1994||Jun 13, 1995||Thermotrex Corporation||Skin surface peeling process using laser|
|US5425728 *||Jan 19, 1993||Jun 20, 1995||Tankovich; Nicolai I.||Hair removal device and method|
|CA1041610A *||Jun 28, 1974||Oct 31, 1978||Block Carol Ltd||Method and apparatus for photoepilation|
|CA1208702A *||Jan 19, 1983||Jul 29, 1986||Neville A Baron||Apparatus for recurving the cornea of an eye|
|DE2515697A1 *||Apr 10, 1975||Oct 23, 1975||Us Energy||Fotochemische stimulierung von nerven|
|DE3220962A1 *||Jun 3, 1982||Dec 15, 1983||Stellario Rodilosso||Novel laser application|
|EP0064967A1 *||Apr 23, 1982||Nov 17, 1982||N.V. Sopar S.A.||Process for producing submicroscopic particles, particles obtained in that way and pharmaceutical compositions containing them|
|FR2267122A1 *||Title not available|
|FR2590791A1 *||Title not available|
|FR2595239A1 *||Title not available|
|JP63249577A||Title not available|
|JPS63249577A *||Title not available|
|WO1980002640A1 *||May 28, 1980||Dec 11, 1980||E Chalmers||Epilation method and system|
|WO1986002783A1 *||Oct 24, 1985||May 9, 1986||Candela Corporation||Long pulse tunable dye laser|
|WO1990011797A1 *||Mar 27, 1990||Oct 18, 1990||The Regents Of The University Of California||Photochemical treatment of blood vessels|
|WO1991004073A1 *||Sep 11, 1990||Apr 4, 1991||The Trustees Of Columbia University In The City Of New York||Laser tissue welding with dye enhanced solders|
|WO1991013652A1 *||Mar 14, 1991||Sep 19, 1991||Candela Laser Corporation||Apparatus for treating abnormal pigmentation of the skin|
|WO1991013653A1 *||Mar 14, 1991||Sep 19, 1991||Candela Laser Corporation||Apparatus and method of treating pigmented lesions using pulsed irradiation|
|WO1993021842A1 *||Feb 22, 1993||Nov 11, 1993||Quadra Logic Technologies, Inc.||High-power light-emitting diodes for photodynamic therapy|
|WO1993021992A1 *||Apr 30, 1993||Nov 11, 1993||Institute Of Dental Surgery||Laser treatment|
|1||*||Investigation and Therapy in Dermatology A. Anders, et al. Conf. Laser 77 Optics Electronics (20 24 Jun. 1977).|
|2||Investigation and Therapy in Dermatology A. Anders, et al.--Conf. Laser 77 Optics-Electronics (20-24 Jun. 1977).|
|3||*||Porphyrins in Tumor Phototherapy Andereoni 1984 pp. 143 155.|
|4||Porphyrins in Tumor Phototherapy--Andereoni 1984--pp. 143-155.|
|Citing Patent||Filing date||Publication date||Applicant||Title|
|US5925035 *||Aug 1, 1996||Jul 20, 1999||Thermolase Corporation||Hair removal method|
|US6030374 *||May 29, 1998||Feb 29, 2000||Mcdaniel; David H.||Ultrasound enhancement of percutaneous drug absorption|
|US6074385 *||Feb 3, 1998||Jun 13, 2000||Kiefer Corp.||Hair follicle devitalization by induced heating of magnetically susceptible particles|
|US6152917 *||Dec 18, 1997||Nov 28, 2000||Thermolase Corporation||Hair removal device|
|US6162211 *||Dec 4, 1997||Dec 19, 2000||Thermolase Corporation||Skin enhancement using laser light|
|US6183773||Jan 4, 1999||Feb 6, 2001||The General Hospital Corporation||Targeting of sebaceous follicles as a treatment of sebaceous gland disorders|
|US6228074 *||Oct 15, 1998||May 8, 2001||Stephen Almeida||Multiple pulse photo-epilator|
|US6283956||Nov 30, 1998||Sep 4, 2001||David H. McDaniels||Reduction, elimination, or stimulation of hair growth|
|US6352506 *||Jul 14, 1999||Mar 5, 2002||Altea Technologies||Controlled removal of biological membrane by pyrotechnic charge for transmembrane transport|
|US6358242||Nov 12, 1999||Mar 19, 2002||Ceramoptec Industries, Inc.||Post laser treatment for permanent hair removal|
|US6398753||Oct 9, 1998||Jun 4, 2002||Mcdaniel David H.||Ultrasound enhancement of percutaneous drug absorption|
|US6413253 *||Nov 3, 1998||Jul 2, 2002||Cooltouch Corporation||Subsurface heating of material|
|US6527716||Dec 30, 1997||Mar 4, 2003||Altea Technologies, Inc.||Microporation of tissue for delivery of bioactive agents|
|US6533775 *||May 5, 2000||Mar 18, 2003||Ioana M. Rizoiu||Light-activated hair treatment and removal device|
|US6595986||Apr 25, 2001||Jul 22, 2003||Stephen Almeida||Multiple pulse photo-dermatological device|
|US6600951||Dec 16, 1999||Jul 29, 2003||The General Hospital Corporation||Targeting of sebaceous follicles as a Treatment of sebaceous gland disorders|
|US6629971 *||Feb 15, 2001||Oct 7, 2003||Mcdaniel David||Process for stimulating hair growth|
|US6663658||Apr 27, 2000||Dec 16, 2003||The General Hospital Corporation||Phototherapy method for treatment of acne|
|US6730028||Oct 29, 2001||May 4, 2004||Altea Therapeutics Corporation||Controlled removal of biological membrane by pyrotechnic charge for transmembrane transport|
|US6743222||Dec 7, 2000||Jun 1, 2004||Candela Corporation||Method of treating disorders associated with sebaceous follicles|
|US6897238||Aug 14, 2001||May 24, 2005||General Hospital Corporation||Topical aminolevulinic acid-photodynamic therapy for the treatment of acne vulgaris|
|US6936044 *||Nov 8, 2001||Aug 30, 2005||Light Bioscience, Llc||Method and apparatus for the stimulation of hair growth|
|US7004933 *||Jun 8, 2001||Feb 28, 2006||Light Bioscience L.L.C.||Ultrasound enhancement of percutaneous drug absorption|
|US7097639||Jun 20, 2003||Aug 29, 2006||Zian Medical, Llc||Dual filter multiple pulse photo-dermatological device with pre/post optical heating, quasi-logarithmic spacing, and laser rod spectrum infusion|
|US7118563||Feb 19, 2004||Oct 10, 2006||Spectragenics, Inc.||Self-contained, diode-laser-based dermatologic treatment apparatus|
|US7201765||May 2, 2005||Apr 10, 2007||Light Bioscience Llc||Method and apparatus for acne treatment|
|US7250045||Feb 19, 2004||Jul 31, 2007||Spectragenics, Inc.||Self-contained, eye-safe hair-regrowth-inhibition apparatus and method|
|US7413567||Feb 25, 2004||Aug 19, 2008||Spectragenics, Inc.||Optical sensor and method for identifying the presence of skin|
|US7452356||Feb 19, 2004||Nov 18, 2008||Tria Beauty, Inc.||Eye-safe dermatologic treatment apparatus|
|US7494503||Apr 10, 2007||Feb 24, 2009||Light Bioscience, Llc||Method and apparatus for acne prevention|
|US7703458 *||Feb 19, 2004||Apr 27, 2010||Cutera, Inc.||Methods and devices for non-ablative laser treatment of dermatologic conditions|
|US7758561||Feb 6, 2004||Jul 20, 2010||Altea Therapeutics Corporation||Microporation of tissue for delivery of bioactive agents|
|US7763299||Jul 27, 2010||Dole Fresh Vegetables, Inc.||Method for processing vegetables having core and leafy ends|
|US7837675||May 31, 2005||Nov 23, 2010||Shaser, Inc.||Method and device for skin treatment with replaceable photosensitive window|
|US7891362||Feb 22, 2011||Candela Corporation||Methods for treating pigmentary and vascular abnormalities in a dermal region|
|US7981111||Feb 25, 2004||Jul 19, 2011||Tria Beauty, Inc.||Method and apparatus for the treatment of benign pigmented lesions|
|US8016811||Sep 13, 2011||Altea Therapeutics Corporation||Method for transdermal delivery of permeant substances|
|US8116860||Jan 22, 2008||Feb 14, 2012||Altea Therapeutics Corporation||Transdermal porator and patch system and method for using same|
|US8246611||Aug 21, 2012||Candela Corporation||Treatment of skin by spatial modulation of thermal heating|
|US8246613||Oct 4, 2010||Aug 21, 2012||Shaser, Inc.||Method and apparatus of treating tissue|
|US8252749||Sep 27, 2007||Aug 28, 2012||Follica, Inc.||Methods, kits, and compositions for generating new hair follicles and growing hair|
|US8277495||Oct 2, 2012||Candela Corporation||Method and apparatus for treating a diseased nail|
|US8322275||Jul 22, 2010||Dec 4, 2012||Dole Fresh Vegetables, Inc.||Top and tail system for leafy vegetables|
|US8474463||Mar 16, 2010||Jul 2, 2013||Cutera, Inc.||Methods and devices for non-ablative laser treatment of dermatologic conditions|
|US8517958||Nov 12, 2010||Aug 27, 2013||Nitto Denko Corporation||Transdermal integrated actuator device, methods of making and using same|
|US8549996||May 28, 2010||Oct 8, 2013||Dole Fresh Vegetables, Inc.||System for topping and tailing lettuce heads using a camera-guided servo-controlled water knife|
|US8551104||Oct 10, 2006||Oct 8, 2013||Tria Beauty, Inc.||Self-contained, diode-laser-based dermatologic treatment apparatus|
|US8641689||Oct 13, 2011||Feb 4, 2014||Nitto Denko Corporation||Transdermal porator and patch system and method for using same|
|US8651111||Apr 28, 2005||Feb 18, 2014||David H. McDaniel||Photomodulation methods and devices for regulating cell proliferation and gene expression|
|US8651112||Apr 2, 2010||Feb 18, 2014||David McDaniel||Process for treatment of psoriasis|
|US8706210||Jan 27, 2009||Apr 22, 2014||Nitto Denko Corporation||Transdermal integrated actuator device, methods of making and using same|
|US8709003||Aug 8, 2008||Apr 29, 2014||Tria Beauty, Inc.||Capacitive sensing method and device for detecting skin|
|US8777935||Aug 18, 2008||Jul 15, 2014||Tria Beauty, Inc.||Optical sensor and method for identifying the presence of skin|
|US8802154||Sep 6, 2013||Aug 12, 2014||Sienna Labs, Inc.||Thermal treatment of a pilosebaceous unit with nanoparticles|
|US8821940||Sep 6, 2013||Sep 2, 2014||Sienna Labs, Inc.||Thermal treatment of the skin surface with nanoparticles|
|US8821941||Sep 6, 2013||Sep 2, 2014||Sienna Labs, Inc.||Hair removal with nanoparticles|
|US8834933||Sep 6, 2013||Sep 16, 2014||Sienna Labs, Inc.||Thermal treatment of acne with nanoparticles|
|US8895071||Aug 28, 2014||Nov 25, 2014||Sienna Labs, Inc.||Thermal treatment of a pilosebaceous unit with coated metal nanoparticles|
|US8906418||Aug 28, 2014||Dec 9, 2014||Sienna Labs, Inc.||Thermal treatment of a pilosebaceous unit with nanoparticles with coatings that facilitate selective removal from the skin surface|
|US9017391||Aug 21, 2009||Apr 28, 2015||L'oreal||Method and apparatus for skin treatment|
|US9028469||Sep 28, 2006||May 12, 2015||Candela Corporation||Method of treating cellulite|
|US9033950||Jul 29, 2011||May 19, 2015||Nitto Denko Corporation||Method for transdermal delivery of permeant substances|
|US9061056||Aug 26, 2011||Jun 23, 2015||Sienna Labs, Inc.||Compositions and methods for targeted thermomodulation|
|US9108045||Dec 24, 2009||Aug 18, 2015||The General Hospital Corporation||Method and apparatus for optical inhibition of photodynamic therapy|
|US9144690||Aug 31, 2009||Sep 29, 2015||L'oreal||System and method for the photodynamic treatment of burns, wounds, and related skin disorders|
|US9192780||Feb 3, 2006||Nov 24, 2015||L'oreal||Low intensity light therapy for treatment of retinal, macular, and visual pathway disorders|
|US9212294||Apr 8, 2015||Dec 15, 2015||Nanocomposix, Inc.||Silver nanoplate compositions and methods|
|US9227082||Aug 31, 2009||Jan 5, 2016||L'oreal||Method and apparatus for acne treatment using low intensity light therapy|
|US9249334||Oct 8, 2013||Feb 2, 2016||Nanocomposix, Inc.||Silver nanoplate compositions and methods|
|US20030036749 *||Nov 5, 2001||Feb 20, 2003||Durkin Anthony J.||Method of treating disorders associated with sebaceous follicles|
|US20030078499 *||Oct 17, 2002||Apr 24, 2003||Eppstein Jonathan A.||Microporation of tissue for delivery of bioactive agents|
|US20030092982 *||Oct 31, 2002||May 15, 2003||Eppstein Jonathan A.||Microporation of tissue for delivery of bioactive agents|
|US20040006328 *||Jul 2, 2003||Jan 8, 2004||Anderson Richard Rox||Targeting of sebaceous follicles as a treatment of sebaceous gland disorders|
|US20040039342 *||Mar 11, 2003||Feb 26, 2004||Jonathan Eppstein||Transdermal integrated actuator device, methods of making and using same|
|US20040048842 *||Sep 10, 2002||Mar 11, 2004||Mcmillan Kathleen||Method of treating skin disorders|
|US20040143247 *||Oct 31, 2003||Jul 22, 2004||Anderson R. Rox||Method and apparatus for treating wrinkles in skin using radiation|
|US20040167499 *||Feb 19, 2004||Aug 26, 2004||Grove Robert E.||Eye-safe dermatologic treatment apparatus and method|
|US20040167500 *||Feb 19, 2004||Aug 26, 2004||Weckwerth Mark V.||Self-contained, diode-laser-based dermatologic treatment apparatus and method|
|US20040167502 *||Feb 25, 2004||Aug 26, 2004||Weckwerth Mark V.||Optical sensor and method for identifying the presence of skin|
|US20040176754 *||Mar 5, 2004||Sep 9, 2004||Island Tobin C.||Method and device for sensing skin contact|
|US20040176823 *||Feb 25, 2004||Sep 9, 2004||Island Tobin C.||Acne treatment device and method|
|US20040176824 *||Mar 3, 2004||Sep 9, 2004||Weckwerth Mark V.||Method and apparatus for the repigmentation of human skin|
|US20040220456 *||Feb 6, 2004||Nov 4, 2004||Altea Therapeutics Corporation||Microporation of tissue for delivery of bioactive agents|
|US20050107852 *||Feb 19, 2004||May 19, 2005||Michael Levernier||Methods and devices for non-ablative laser treatment of dermatologic conditions|
|US20050143466 *||Oct 20, 2004||Jun 30, 2005||Anderson Richard R.||Topical aminolevulinic acid-photodynamic therapy for the treatment of acne vulgaris|
|US20050165393 *||Mar 16, 2005||Jul 28, 2005||Eppstein Jonathan A.||Microporation of tissue for delivery of bioactive agents|
|US20050256515 *||Jun 8, 2005||Nov 17, 2005||Anderson R R||Method and apparatus for treating wrinkles in skin using radiation|
|US20050261750 *||May 2, 2005||Nov 24, 2005||Light Bioscience, Llc||Method and apparatus for acne treatment|
|US20050283211 *||Apr 28, 2005||Dec 22, 2005||Light Bioscience, Llc||Photomodulation methods and devices for regulating cell proliferation and gene expression|
|US20060020260 *||May 31, 2005||Jan 26, 2006||Dover Jeffrey S||Method and apparatus of treating tissue|
|US20060129209 *||Aug 29, 2005||Jun 15, 2006||Light Bioscience, Llc||Method and apparatus for the stimulation of hair growth|
|US20060184214 *||Feb 3, 2006||Aug 17, 2006||Light Bioscience, Llc||Low intensity light therapy for treatment of retinal, macular, and visual pathway disorders|
|US20060200213 *||Jan 17, 2006||Sep 7, 2006||Mcdaniel David H||Method and apparatus for skin treatment|
|US20060212025 *||Mar 3, 2006||Sep 21, 2006||Light Bioscience, Llc||Method and apparatus for acne treatment|
|US20060212098 *||Sep 16, 2005||Sep 21, 2006||Constantinos Demetriou||Method and apparatus for treating a diseased nail|
|US20070032847 *||Oct 10, 2006||Feb 8, 2007||Spectragenics, Inc.||Self-contained, diode-laser-based dermatologic treatment apparatus|
|US20070073367 *||Sep 28, 2006||Mar 29, 2007||Jones Christopher J||Method of treating cellulite|
|US20070083190 *||Oct 11, 2006||Apr 12, 2007||Yacov Domankevitz||Compression device for a laser handpiece|
|US20070173799 *||Sep 1, 2006||Jul 26, 2007||Hsia James C||Treatment of fatty tissue adjacent an eye|
|US20070176262 *||Aug 11, 2006||Aug 2, 2007||Ernest Sirkin||Series connection of a diode laser bar|
|US20070191822 *||Apr 10, 2007||Aug 16, 2007||Light Bioscience, Llc||Method and apparatus for acne prevention|
|US20070198003 *||Dec 22, 2006||Aug 23, 2007||Yacov Domankevitz||Treating dermatological conditions using an alexandrite laser|
|US20080009923 *||Jun 14, 2007||Jan 10, 2008||Paithankar Dilip Y||Treatment of Skin by Spatial Modulation of Thermal Heating|
|US20080027518 *||Jul 27, 2007||Jan 31, 2008||Spectragenics, Inc.||Self-contained, eye-safe hair-regrowth-inhibition apparatus and method|
|US20080072924 *||Jul 31, 2007||Mar 27, 2008||Sumitomo Electric Industries, Ltd.||Fouling removing method|
|US20080091179 *||Jul 13, 2007||Apr 17, 2008||Candela Corporation||Compact, handheld device for home-based acne treatment|
|US20080208107 *||Jan 22, 2008||Aug 28, 2008||Mcrae Stuart||Transdermal porator and patch system and method for using same|
|US20080221649 *||Mar 9, 2007||Sep 11, 2008||Agustina Echague||Method of sequentially treating tissue|
|US20090043294 *||Aug 8, 2008||Feb 12, 2009||Spectragenics, Inc.||Capacitive Sensing Method and Device for Detecting Skin|
|US20090204109 *||Nov 14, 2008||Aug 13, 2009||Tria Beauty, Inc.||Eye-Safe Dermatologic Treatment Apparatus and Method|
|US20090264810 *||Oct 22, 2009||Eppstein Jonathan A||Transdermal Integrated Actuator Device, Methods of Making and Using Same|
|US20090270848 *||Oct 29, 2009||Tria Beauty, Inc.||Optical Sensor and Method for Identifying the Presence of Skin and the Pigmentation of Skin|
|US20090274809 *||Jul 13, 2009||Nov 5, 2009||Dole Fresh Vegetables, Inc.||Top and tail system for leafy vegetables|
|US20090299268 *||Dec 3, 2009||The General Hospital Corporation D/B/A Massachusetts General Hospital||Topical Aminolevulinic Acid-Photodynamic Therapy for the Treatment of Acne Vulgaris|
|US20100055789 *||Mar 4, 2010||Mcdaniel David H||Method and apparatus for the stimulation of hair growth|
|US20100069898 *||Mar 18, 2010||Tria Beauty, Inc.||Acne Treatment Method, System and Device|
|US20100120768 *||Sep 27, 2007||May 13, 2010||David Steinberg||Methods, kits, and compositions for generating new hair follicles and growing hair|
|US20100121254 *||Aug 21, 2009||May 13, 2010||Mcdaniel David H||Method and apparatus for skin treatment|
|US20100137950 *||Aug 31, 2009||Jun 3, 2010||Mcdaniel David H||System and method for the photodynamic treatment of burns, wounds, and related skin disorders|
|US20100174222 *||Jul 8, 2010||Mcdaniel David H||Method and apparatus for acne treatment using low intensity light therapy|
|US20100217212 *||Aug 26, 2010||Eppstein Jonathan A||Microporation of Tissue for Delivery of Bioactive Agents|
|US20100222853 *||Sep 2, 2010||Cutera, Inc.||Methods and devices for non-ablative laser treatment of dermatologic conditions|
|US20100256550 *||Apr 2, 2010||Oct 7, 2010||Mcdaniel David||Process for treatment of psoriasis|
|US20100285194 *||Nov 11, 2010||Dole Fresh Vegetables, Inc.||Top and tail system for leafy vegetables|
|US20110082446 *||Oct 4, 2010||Apr 7, 2011||Shaser, Inc.||Method and Apparatus of Treating Tissue|
|US20110190745 *||Aug 4, 2011||Uebelhoer Nathan S||Treatment of sweat glands|
|US20130312780 *||Feb 20, 2012||Nov 28, 2013||Radiancy Inc.||Hair Treatment Apparatus|
|WO2000033912A2||Dec 4, 1999||Jun 15, 2000||Joseph Neev||Energy application with cooling|
|WO2000040266A2 *||Dec 16, 1999||Jul 13, 2000||The General Hospital Corporation D/B/A||Targeting of sebaceous follicles as a treatment of sebaceous gland disorders|
|WO2000040266A3 *||Dec 16, 1999||Jan 18, 2001||Gen Hospital Corp D B A||Targeting of sebaceous follicles as a treatment of sebaceous gland disorders|
|WO2003039478A2||Nov 8, 2002||May 15, 2003||Light Bioscience, Inc.||Method and apparatus for the stimulation of hair growth|
|U.S. Classification||606/9, 606/133|
|International Classification||A61B17/00, A61M37/00, A61B17/22, A61M1/00, A61B18/20, A61N5/067, A61B18/14, A61N5/06|
|Cooperative Classification||A61B2017/00747, A61M37/00, A61M37/0092, A61N2005/067, A61B2217/005, A61B18/203, A61B2018/00476, A61B2017/22085, A61M2037/0007, A61B18/20, A61B2017/00752, A61B18/1442, A61N5/0616, A61B2017/00761, A61N5/062, A61B2018/00452|
|European Classification||A61M37/00, A61M37/00U, A61B18/20H, A61B18/14F, A61N5/06C8, A61N5/06C2|
|Nov 6, 1997||AS||Assignment|
Owner name: THERMOLASE CORPORATION, CALIFORNIA
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:THERMOTREX CORPORATION;REEL/FRAME:008783/0495
Effective date: 19970911
Owner name: THERMOLASE CORPORATION, CALIFORNIA
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:TANKOVICH, NIKOLAI;EPISCOPO, RICHARD;SVERDRUP, LAWRENCE;AND OTHERS;REEL/FRAME:008783/0515
Effective date: 19971008
|Dec 11, 2001||REMI||Maintenance fee reminder mailed|
|May 20, 2002||LAPS||Lapse for failure to pay maintenance fees|
|Jul 16, 2002||FP||Expired due to failure to pay maintenance fee|
Effective date: 20020519