|Publication number||US5922393 A|
|Application number||US 09/110,225|
|Publication date||Jul 13, 1999|
|Filing date||Jul 6, 1998|
|Priority date||Aug 6, 1996|
|Also published as||US5713949, US5895407|
|Publication number||09110225, 110225, US 5922393 A, US 5922393A, US-A-5922393, US5922393 A, US5922393A|
|Original Assignee||Jayaraman; Swaminathan|
|Export Citation||BiBTeX, EndNote, RefMan|
|Patent Citations (10), Referenced by (168), Classifications (30), Legal Events (7)|
|External Links: USPTO, USPTO Assignment, Espacenet|
This application is a divisional from application Ser. No. 09/008,700, filed Jan. 19, 1998, which is a divisional of Ser. No. 08/689,290, filed Aug. 6, 1996, now U.S. Pat. No. 5,713,949.
The present invention relates to a covered microporous stent and method of coating. Coated stents are known as are stents that are designed to expand at the site within a blood vessel where they are intended to engage the internal wall of the blood vessel to reinforce it.
Currently available stents are known to cause restenosis. Restenosis can be caused by incompatibility of the metallic surface of the stent that engages the inner walls of the blood vessel giving rise to subacute thrombosis, usually within four weeks of implantation of the stent. Another possible cause of restenosis is the recoil of the metallic surface of the stent when placed along the internal wall of the artery. Such recoil does not occur immediately, but, rather, when the stent pulses due to its elastic nature, stresses act downwardly toward the stent resulting in gradual diminishing of the luminal diameter.
Additionally, most commercially available stents have an open mesh area when they are expanded and rapid ingrowth of collagen cells and smooth muscle cells gradually occurs through these open areas. Collagen cells contributing toward intimal hyperplasia eventually result in the narrowing of the lumen diameter. Additionally, sometimes, at the location where the stent is to be placed, such as, for example, in saphenous vein grafts, thrombus exists that must be bypassed. Finally, in the aorta and peripheral arteries, a large portion of the aneurysmal sac may have to be bypassed prior to stent implantation.
Use of polymeric or biologic material to coat a stent is generally known. However, in such coated stents, when they are expanded within a blood vessel, the coefficient of expansion of the coating greatly differs from that of the expanding stent such that, upon expansion, the surface of the coating tears rendering the expanded stent uncoated. If, as a solution, the coating is applied more thickly, such a thick coating can deter stent expansion or can have such a high profile that implantation into the body is difficult. The same problem occurs when a stent is coated by sandwiching it between inner and outer coating layers. If the stent cannot be expanded to its full intended diameter, the success of the implantation can be drastically compromised.
While the prior art does describe the concept of providing a stent with a coating, Applicant is unaware of any prior art that specifically describes whether such a coating surrounds the individual members of the metallic stent or whether such a coating covers all of the gaps between the various interstices of the expanded stent.
The prior art also describes biologic coatings such as collagen gelatin to be employed on a balloon expandable or thermally expandable stent. To coat such a stent, it is placed in a mandrel and then dipped into the biologic solution and then dried in an oven. Applicant is unaware of the nature of the resulting properties of the stent when expanded.
Applicant is also aware that stents have been coated with a polymeric material such as silicone that renders the resulting stent impervious to any incursion of biologic tissue. However, in such stents, the impervious nature of the coating deters the healing of the surrounding tissues.
The following prior art is known to Applicant:
U.S. Pat. No. 5,234,457 to Andersen
U.S. Pat. No. 5,330,500 to Song
U.S. Pat. No. 5,344,426 to Lau et al.
U.S. Pat. No. 5,443,499 to Schmitt.
None of these patents teaches the features and aspects of the present invention as set forth hereinbelow, including the particular stent coatings nor the method of so coating a stent.
The present invention relates to a polymer or biological material coated microporous stent and method of coating. The present invention includes the following interrelated objects, aspects and features:
(1) In a first aspect, in the preferred embodiments of the present invention, the inventive stent consists of a tubular member made from a flat sheet assembled together in a tube with the ends of the sheet assembled together through a technique such as surface fusing by employing means such as plasma energy, LASER or ultrasound. Preferably, the stent is made up of a plurality of spaced rows of slots with spaces between adjacent slots within a row staggered with respect to corresponding spaces on adjacent rows.
(2) In a first embodiment of a coated stent, a coating is attached to the stent only at a single area of line contact on the outer surface of the stent with the remainder of the coating being larger than the unexpanded stent, but being made of dimensions designed to snugly receive the outer surfaces of the stent when it is expanded within a blood vessel.
(3) In the method of making the above-described coating, the unexpanded stent is placed over a mandrel and is then inserted within an elongated recess eccentrically located within a larger mandrel with the recess having an elongated opening on a peripheral edge thereof. When the stent so assembled to the mandrels is covered with the coating, the coating surrounds the outer mandrel and connects with the stent only at the area of the peripheral linear opening. When the mandrels are removed, what remains is the stent having an enlarged coating attached thereto only at one linear elongated location. This embodiment is practiced concerning a stent that is intended to be expanded through the use of expansion means such as, for example, a balloon catheter or a mechanical expanding tool.
(4) The present invention also contemplates coating of a stent of the type known as a "self-expanding" stent that is programmed to self-expand at a particular temperature by either using the shape memory properties of the metal or by using the flexibility and elasticity of the metal. In this embodiment, prior to programming the formed stent, the stent is placed in a container of coating material and is coated. Thereafter, the stent is programmed in the desired manner and is subsequently physically compressed and kept inside a sheath. The stent is placed within the blood vessel still within the sheath, and the sheath is then removed, allowing the stent to expand to its desired configuration.
The present invention is intended to fulfill the following objects, aspects and features:
(1) To develop an ultrathin thin coating on a stent that is so configured that, when the stent is expanded, the outer expanded diameter of the stent is equal to the inner wall diameter of the coating with the structure of the coating being uncompromised.
(2) The coating so developed has the property of microporosity that facilitates controlled ingrowth of tissue within the coating to provide a neoinitimal healing mechanism.
(3) The coating may be provided with specific substances that are designed to enhance the healing properties of the stent.
(4) The wall thickness of the coating is intended to be extremely thin, on the order of 5 to 80 mils in thickness. For larger diameters the thickness of the coating can be up to 100 mils thick.
(5) The coating provides a conduit for dilatation of the plaque, can bypass a thrombus or eliminate an aneurysmal sac.
It is a further object to provide a plurality of such stents attached together in a manner to be described in greater detail hereinafter. In this regard, the length of the coating and the stent may be varied so that the stent runs some or all of the entire length of the microporous coating. Additionally, if desired, the stent may be intermittently placed within the coating or may be placed at only the proximal and distal ends thereof.
These and other objects, aspects and features of the present invention will be better understood from the following detailed description of the preferred embodiments when read in conjunction with the appended drawing figures.
FIG. 1 shows a top view of a flat piece of material intended to be formed into a stent.
FIG. 2 shows a perspective view of the material shown in FIG. 1 formed into a stent.
FIG. 3 shows an exploded perspective view of the stent shown in FIG. 2 with relation to a solid plastic mandrel over which it is to be placed.
FIG. 4 shows the stent placed over the mandrel of FIG. 3.
FIGS. 5 and 6 show the process of placing the stent and mandrel of FIG. 4 within a recess of a larger mandrel.
FIG. 7 shows a cross-sectional view along the line 7--7 of FIG. 6 after the coating process has taken place.
FIG. 8 shows the process of removing the coated stent from the larger mandrel.
FIG. 9 shows a cross-sectional view along the line 9--9 of FIG. 8.
FIGS. 10 and 11 show top views of two different embodiments of stents made up of a plurality of stent sections interconnected together.
FIG. 12 shows a side view of the configuration of the stent and mandrels shown in FIG. 6.
FIG. 13 shows a side view of an alternative process wherein two stents are coated on a single mandrel.
FIG. 14 shows a side view of the practicing of a further process wherein three spaced stents are coated on a single mandrel.
FIG. 15 shows the process of inserting a balloon catheter within the coated stent.
FIG. 16 shows the balloon catheter within the stent with the outer coating wrapped closely therearound for insertion.
FIGS. 17 and 18 show an exploded perspective view and a perspective view, respectively, of the process for attaching a stent over a mandrel in a further process in accordance with the teachings of the present invention.
FIG. 19 shows a plurality of mandrels and stents corresponding to FIGS. 17 and 18 and suspended within a bath of coating material within a tank.
FIG. 20 shows the stents of FIG. 19, after coating, and placed within an oven to dry the coating material.
FIG. 21 shows a side view of a stent coated in accordance with the teachings of the process illustrated in FIGS. 17-20.
FIGS. 22, 23 and 24 show the sequential process for inserting the stent, coated in accordance with the process illustrated in FIGS. 17-20, within a blood vessel.
With reference to FIG. 1, a flat piece of material is generally designated by the reference numeral 1 and is seen to include a top edge 2, a bottom edge 3, and ends 4 and 5. The piece of material 1 includes rows 6, 7 of slots with the rows 6 alternating with the rows 7. Spaces or solid wall portions 8 in the rows 6 between adjacent slots are staggered with respect to spaces or solid wall portions 9 in adjacent rows 7 as clearly seen in the figure. With reference to FIG. 2, the piece of material 1 is formed into a generally cylindrical stent 10 with the edges 2, 3 attached together by any suitable means such as, for example, by surface fusing, employing plasma energy, LASER or ultrasound. Of course, any suitable means for fastening the edges 2, 3 together may be employed.
The stent 10 may be coated, in a first inventive process, in the manner described with reference to FIGS. 3-9. As seen in FIGS. 3 and 4, the stent 10 may be placed over a solid plastic or metal generally cylindrical mandrel 15 so that the inner surface 11 of the stent 10 snugly engages the outer surface 17 of the mandrel 15 in the manner seen in FIGS. 7 and 9. With the stent 10 so mounted as best seen in FIG. 4, the stent 10 and mandrel 15 may be placed within the recess 25 of a second, larger mandrel 20 having a large generally cylindrical outer surface 21. As seen in FIGS. 5 and 7, in particular, the recess 25 is generally cylindrical in nature and is eccentrically placed with respect to the body of the second mandrel 20 so that the recess 25 intersects with the periphery of the mandrel 20 at an elongated slot 23 extending throughout the longitudinal length of the second mandrel 20. FIG. 6 shows the stent 10, the first inner mandrel 15 and the second mandrel 20 as assembled together. In the configuration shown in FIG. 6, the entire assembly is dipped in a bath of coating material so that, as best seen in FIG. 7, a coating 30 is formed about the periphery of the mandrel 20 and attaches to the stent 10 at the area designated by the reference numeral 31 in FIG. 7 that corresponds to the location of the elongated slot 23 within the mandrel 20. As should be understood, the slot 23 permits covering material to enter the recess 25 in the mandrel 20 in an elongated path along the longitudinal length of the stent 10 at one location therealong to affix the coating 30 thereto. Otherwise, the unexpanded stent 10 is uncoated. FIG. 12 shows a side view of the assembly of the coated stent 10 and the mandrels 15 and 20 as seen in FIG. 6.
FIG. 8 shows removal of the stent 10, the mandrel 15 and the coating 30 from the mandrel 20. If necessary, a lubricant may be employed for this purpose. The cross-sectional view of FIG. 9 shows the stent 10 with the coating 30 spaced therefrom except at the area designated by the reference numeral 31 where the coating 30 is firmly attached to the stent 10. Subsequently, the mandrel 15 is removed from the interior of the stent 10.
With reference to FIG. 15, the coated stent 10 is used by inserting a balloon catheter 35 snugly within the unexpanded stent 10 and by loosely wrapping the coating 30 about the stent 10 so that the configuration is small enough to be easily inserted within a blood vessel as shown in FIG. 16. As should now be understood, when the balloon catheter 35 is expanded in a manner well known to those skilled in the art, the stent 10 expands so that the outer surface 12 thereof peripherally engages the inner surface 33 of the coating 30 so that, in the expanded state, the stent 10 is fully covered with a coating that has complete integrity.
FIG. 10 shows a plurality of flat pieces 1a, 1b and 1c interconnected together by resilient flexible connectors 40, each of which consists of a series of rows of generally "X"-shaped members fixed together as shown. As should be understood, the device shown in FIG. 10 may be assembled into a triple stent by forming the entire assembly into a roll as understood with reference to FIGS. 1 and 2.
FIG. 11 shows an assembly 50 that consists of regions 51, 53 and 59, each one of which corresponds to the flat piece of material 1 as seen in FIG. 1. The members 51 and 53 are interconnected together by the connecting portion 57 while the members 53 and 59 are interconnected together by the connecting portion 55. The device 50 illustrated in FIG. 11 may be assembled into a triple stent, again, in the manner that should be understood from FIGS. 1 and 2. The connecting portions 57 and 55 allow longitudinal expansion of the length of the device 50 in the directions of the double headed arrow 61.
In the embodiments illustrated in FIGS. 10 and 11, the free edges 2', 3' and 2", 3", respectively, may be interconnected in the manner described with reference to FIG. 2.
The flat piece of material 1, 1a, 1b or 1c is manufactured by using a laser cutting tool to prepare the slots in rows 6 and 7 in either a sheet of metal or plastic. The laser tool cuts out each of the slots for rows 6 and 7 from a preprogrammed pattern. The metal can be stainless steel, titanium, nickel, a thermal alloy such as NITNOL or other metal compatible with a patient's vascular tissue. The coating 30 is a biocompatible material such as polyurethane, polyethylene, polytetrafluroethylene, silicone, block co-polymers of polyurethane, polyethylene and silicone, a biodegradable polymer such as polylactic acid, polyglycollic acid, and or hydroxy butyrate or valerate co-polymer. Biocompatible material will not interfere with blood or blood vessel interior wall tissue. The polymers can include anticoagulant agents, growth factor and like agents for reducing the reaction of blood to foreign surfaces.
Plastics employed to make the flat piece of material 1, 1a, 1b or 1c can be polyethylene, polyurethane, polytetrafluroethylene, silicone or copolymer of polyurethane and polyethylene compatible with the vascular tissue of a patient.
With reference to FIG. 12, as explained hereinabove, the mandrel 20 has been employed to create a single coated stent 10. FIG. 13 shows the use of the mandrel 20 to provide coatings 30a and 30b on two stents 10a and 10b. Alternatively, FIG. 14 shows the use of the mandrel 20 to create three coatings 30a, 30b and 30c on respective stents 10a, 10b and 10c.
With reference, now, to FIGS. 17-20, a further process in accordance with the teachings of the present invention is depicted. In FIGS. 17 and 18, a stent 70 is shown that is of the type that is known as "self-expandable". Such a stent is programmed to self-expand at a particular temperature either by using the shape memory properties of the metal or by using the inherent flexibility and elasticity thereof. The stent 70 as depicted in FIGS. 17 and 18 is shown prior to the programming step. A mandrel 71 is inserted within the stent 70. Thereafter, with reference to FIG. 19, one or more stents 70 are dipped in a container 73 containing a liquid coating with the mandrels 71 being supported on a support 75 in a manner that should be well understood. For example, the container 73 may contain a polymeric coating material. After sufficient time has elapsed with the stent 70 immersed within the bath in the container 73, the stents 70 are removed from the bath, still attached to their respective mandrels 71, and are subsequently immersed within a rinse bath to remove excess coating. Thereafter, with reference to FIG. 20, the stents 70, still attached to their respective mandrels 71 which are attached to the support 75, are placed within an oven 80 having an internal chamber 81 with a heating element 83 connectable to a source of power (not shown). The stents 70 are heated to a desired temperature for a desired period of time and excess solvents are removed during the heating process. The suitably coated stent 70 with the coating 72 thereon is seen in FIG. 21.
With reference to FIGS. 22, 23 and 24, a preferred method of use of the stent 70 is seen. After the process depicted in FIGS. 17-20, the stent 70 is suitably programmed. For example, the stent 70 may be dipped into a cold bath at a desired temperature and retained under cool temperature for a period of time so that when it is exposed to body temperature it expands to a desired degree of expansion. In the case of stents that are of the type that expand due to the inherent elasticity thereof, the stent is physically compressed. In either case, in the compressed state, the stent is covered with a non-expansible sheath 85 that prevents expansion until expansion is desired.
FIG. 22 shows the stent 70 encased within the sheath 85 and inserted using an appropriate mechanism 87 into a blood vessel at an appropriate location. With reference to FIG. 23, the sheath 85 is then removed and, with reference to FIG. 24, the stent 70 expands either due to its inherent elasticity or due to exposure to body temperature within the blood vessel and performs its function.
As should be understood from the above description, the process illustrated in FIGS. 17-20 may also be employed in coating the stent employing the mandrels as illustrated in FIGS. 1-9. In either case, for solvent-based polymeric coatings where the solvent can be eluted out of the material by a chemical or mechanical treatment procedure, the polymeric coating solution contains a solvent. The solvent may suitably be removed by heat (as explained with reference to FIG. 20), by vacuum or through the use of a non-solvent. If desired, several dips into the tank 73 may be carried out to provide the desired final wall thickness of the coating.
Concerning the process described with reference to FIGS. 1-9, the portion 31 of the coating where it attaches about the stent 10 may be reinforced with a line of sutures.
With further reference to the process illustrated in FIGS. 1-9, where thin wall coatings are employed that are not solvent based and which can be extruded into a very thin conduit, the conduit may be slipped onto the eccentric mandrel 20 and may be attached to the stent by welding, adhesive or by a line of sutures. Conduits that may be employed in this regard include those made of polyurethane, expanded polytetraflorol ethylene (TEFLON), extruded TEFLON, polyester which may be knit or woven, velour or non-velour, extruded, PET, PE, hydrogels that can impart a desirable elastic nature to the walls of the coating. These choices are merely given by way of example.
Additionally, biological materials such as collagen, gelatin and the like may be suitably employed. In the case of "self-expanding" stents such as the stent 70, the coating material may be solvent based, extruded or biological and may be assembled to the mandrel and attached to the "self-expanding" stent either by a continuous suture or intermittently placed sutures along one axis of the stent or by an adhesive or any other mechanical, thermal or chemical treatment that ensures attachment. The stent and the coating material are together programmed to expand at body temperature. For example, the stent and coating may be dipped in a cold bath with the coating attached to reduce them both to a much smaller size which may then be inserted into a sheath which may be removed within the body to allow expansion to the expanded size when the coating was originally applied.
Hereinabove, the use of a hydrogel material for the coating was suggested. Such a material is especially effective since it is very pliable and elastic and has an extremely slippery surface allowing easy removal from the overlying sheath.
As such, an invention has been disclosed in terms of preferred embodiments thereof which fulfill each and every one of the objects of the invention as set forth hereinabove and provide a new and useful polymer coated microporous stent and method of coating of great novelty and utility.
Of course, various changes, modifications and alterations in the teachings of the present invention may be contemplated by those skilled in the art without departing from the intended spirit and scope thereof.
As such, it is intended that the present invention only be limited by the terms of the appended claims.
|Cited Patent||Filing date||Publication date||Applicant||Title|
|US5234457 *||Oct 9, 1991||Aug 10, 1993||Boston Scientific Corporation||Impregnated stent|
|US5330500 *||Oct 17, 1991||Jul 19, 1994||Song Ho Y||Self-expanding endovascular stent with silicone coating|
|US5344426 *||Apr 15, 1993||Sep 6, 1994||Advanced Cardiovascular Systems, Inc.||Method and system for stent delivery|
|US5443499 *||Mar 8, 1994||Aug 22, 1995||Meadox Medicals, Inc.||Radially expandable tubular prosthesis|
|US5449382 *||Mar 2, 1994||Sep 12, 1995||Dayton; Michael P.||Minimally invasive bioactivated endoprosthesis for vessel repair|
|US5534287 *||Nov 29, 1994||Jul 9, 1996||Schneider (Europe) A.G.||Methods for applying an elastic coating layer on stents|
|US5537729 *||Mar 2, 1993||Jul 23, 1996||The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services||Method of making ultra thin walled wire reinforced endotracheal tubing|
|US5578075 *||Jun 1, 1995||Nov 26, 1996||Michael Peck Dayton||Minimally invasive bioactivated endoprosthesis for vessel repair|
|US5713949 *||Aug 6, 1996||Feb 3, 1998||Jayaraman; Swaminathan||Microporous covered stents and method of coating|
|US5837313 *||Jun 13, 1996||Nov 17, 1998||Schneider (Usa) Inc||Drug release stent coating process|
|Citing Patent||Filing date||Publication date||Applicant||Title|
|US6153252 *||Apr 19, 1999||Nov 28, 2000||Ethicon, Inc.||Process for coating stents|
|US6364903||Mar 19, 1999||Apr 2, 2002||Meadox Medicals, Inc.||Polymer coated stent|
|US6395212||Dec 15, 1999||May 28, 2002||Jan Otto Solem||Covered stent and method of making it|
|US6475234||Oct 26, 1998||Nov 5, 2002||Medinol, Ltd.||Balloon expandable covered stents|
|US6572644 *||Jun 27, 2001||Jun 3, 2003||Advanced Cardiovascular Systems, Inc.||Stent mounting device and a method of using the same to coat a stent|
|US6645547||May 2, 2002||Nov 11, 2003||Labcoat Ltd.||Stent coating device|
|US6733524||Feb 5, 2002||May 11, 2004||Scimed Life Systems, Inc.||Polymer coated stent|
|US6746773||Sep 25, 2001||Jun 8, 2004||Ethicon, Inc.||Coatings for medical devices|
|US6818063||Sep 24, 2002||Nov 16, 2004||Advanced Cardiovascular Systems, Inc.||Stent mandrel fixture and method for minimizing coating defects|
|US6887265||Sep 3, 2002||May 3, 2005||Medinol Ltd.||Balloon expandable covered stents|
|US6887510||Apr 22, 2003||May 3, 2005||Advanced Cardiovascular Systems, Inc.||Method of using a stent mounting device to coat a stent|
|US6916379||Sep 15, 2003||Jul 12, 2005||Labcoat, Ltd.||Stent coating device|
|US6955723||Oct 2, 2003||Oct 18, 2005||Advanced Cardiovascular Systems, Inc.||Mandrel for supporting a stent and method of using the mandrel to coat a stent|
|US6972054 *||Apr 2, 2004||Dec 6, 2005||Advanced Cardiovascular Systems, Inc.||Coupling device for a stent support fixture|
|US7048962||Jul 30, 2002||May 23, 2006||Labcoat, Ltd.||Stent coating device|
|US7074276||Dec 12, 2002||Jul 11, 2006||Advanced Cardiovascular Systems, Inc.||Clamp mandrel fixture and a method of using the same to minimize coating defects|
|US7285132||Mar 24, 2004||Oct 23, 2007||Scimed Life Systems, Inc.||Polymer coated stent|
|US7318836||Mar 11, 2003||Jan 15, 2008||Boston Scientific Scimed, Inc.||Covered stent|
|US7323209||May 15, 2003||Jan 29, 2008||Advanced Cardiovascular Systems, Inc.||Apparatus and method for coating stents|
|US7335265||Oct 8, 2002||Feb 26, 2008||Advanced Cardiovascular Systems Inc.||Apparatus and method for coating stents|
|US7354480||Feb 26, 2003||Apr 8, 2008||Advanced Cardiovascular Systems, Inc.||Stent mandrel fixture and system for reducing coating defects|
|US7402329||Nov 18, 2002||Jul 22, 2008||Advanced Cardiovascular Systems, Inc.||Method of using support device to coat a stent|
|US7416609||Nov 25, 2002||Aug 26, 2008||Advanced Cardiovascular Systems, Inc.||Support assembly for a stent|
|US7485333||Sep 12, 2003||Feb 3, 2009||Advanced Cardiovascular Systems, Inc.||Method of using a stent mounting device to coat a stent|
|US7485334||Apr 2, 2004||Feb 3, 2009||Advanced Cardiovascular Systems, Inc.||Stent mandrel fixture and method for minimizing coating defects|
|US7485335||Nov 24, 2004||Feb 3, 2009||Advanced Cardiovascular Systems, Inc.||Stent mounting device and a method of using the same to coat a stent|
|US7527644||Nov 5, 2002||May 5, 2009||Alveolus Inc.||Stent with geometry determinated functionality and method of making the same|
|US7547321||Jul 5, 2002||Jun 16, 2009||Alveolus Inc.||Removable stent and method of using the same|
|US7556837||Jan 14, 2008||Jul 7, 2009||Advanced Cardiovascular Systems, Inc.||Method for coating stents|
|US7569110||Mar 21, 2006||Aug 4, 2009||Labcoat Ltd.||Stent coating device|
|US7604663||Dec 30, 1999||Oct 20, 2009||St. Jude Medical, Inc.||Medical devices with polymer/inorganic substrate composites|
|US7608099||Feb 17, 2006||Oct 27, 2009||Merit Medical Systems Inc.||Medical appliance delivery apparatus and method of use|
|US7628859||Dec 27, 2002||Dec 8, 2009||Advanced Cardiovascular Systems, Inc.||Mounting assembly for a stent and a method of using the same to coat a stent|
|US7637934||Mar 31, 2003||Dec 29, 2009||Merit Medical Systems, Inc.||Medical appliance optical delivery and deployment apparatus and method|
|US7637942||Sep 24, 2003||Dec 29, 2009||Merit Medical Systems, Inc.||Coated stent with geometry determinated functionality and method of making the same|
|US7648725||May 19, 2006||Jan 19, 2010||Advanced Cardiovascular Systems, Inc.||Clamp mandrel fixture and a method of using the same to minimize coating defects|
|US7709048||Nov 5, 2004||May 4, 2010||Labcoat, Ltd.||Method and apparatus for coating a medical device|
|US7735449||Jul 28, 2005||Jun 15, 2010||Advanced Cardiovascular Systems, Inc.||Stent fixture having rounded support structures and method for use thereof|
|US7743727||Feb 3, 2006||Jun 29, 2010||Boston Scientific Scimed, Inc.||Stent coating apparatus and method|
|US7749554 *||Jan 4, 2008||Jul 6, 2010||Advanced Cardiovascular Systems, Inc.||Method for coating stents|
|US7766884||May 25, 2007||Aug 3, 2010||Advanced Cardiovascular Systems, Inc.||Polymers of fluorinated monomers and hydrophilic monomers|
|US7770537||Aug 12, 2008||Aug 10, 2010||Boston Scientific Scimed, Inc.||Stent coating device|
|US7776381||Sep 26, 2002||Aug 17, 2010||Advanced Cardiovascular Systems, Inc.||Stent mandrel fixture and method for reducing coating defects|
|US7794777||Feb 1, 2008||Sep 14, 2010||Advanced Cardiovascular Systems, Inc.||Method for reducing stent coating defects|
|US7803394||Nov 17, 2006||Sep 28, 2010||Advanced Cardiovascular Systems, Inc.||Polycationic peptide hydrogel coatings for cardiovascular therapy|
|US7823533||Jun 30, 2005||Nov 2, 2010||Advanced Cardiovascular Systems, Inc.||Stent fixture and method for reducing coating defects|
|US7833566||Oct 6, 2008||Nov 16, 2010||Advanced Cardiovascular Systems, Inc.||Stent mandrel fixture and method for reducing coating defects|
|US7867547||Dec 19, 2005||Jan 11, 2011||Advanced Cardiovascular Systems, Inc.||Selectively coating luminal surfaces of stents|
|US7875068||Sep 30, 2003||Jan 25, 2011||Merit Medical Systems, Inc.||Removable biliary stent|
|US7879386||Mar 7, 2008||Feb 1, 2011||Advanced Cardiovascular Systems, Inc.||Support device for a stent and a method of using the same to coat a stent|
|US7892280||Nov 7, 2008||Feb 22, 2011||C. R. Bard, Inc.||Implantable medical devices with fluorinated polymer coatings, and methods of coating thereof|
|US7892592||Nov 30, 2004||Feb 22, 2011||Advanced Cardiovascular Systems, Inc.||Coating abluminal surfaces of stents and other implantable medical devices|
|US7901451||Sep 22, 2005||Mar 8, 2011||Biosensors International Group, Ltd.||Drug-delivery endovascular stent and method for treating restenosis|
|US7901703||Mar 23, 2007||Mar 8, 2011||Advanced Cardiovascular Systems, Inc.||Polycationic peptides for cardiovascular therapy|
|US7918011||Oct 10, 2007||Apr 5, 2011||Abbott Cardiovascular Systems, Inc.||Method for providing radiopaque nitinol alloys for medical devices|
|US7918181||Oct 6, 2008||Apr 5, 2011||Advanced Cardiovascular Systems, Inc.||Stent mandrel fixture and method for reducing coating defects|
|US7938843||Jun 9, 2003||May 10, 2011||Abbott Cardiovascular Systems Inc.||Devices configured from heat shaped, strain hardened nickel-titanium|
|US7942892||May 1, 2003||May 17, 2011||Abbott Cardiovascular Systems Inc.||Radiopaque nitinol embolic protection frame|
|US7959664 *||Mar 15, 2006||Jun 14, 2011||Medinol, Ltd.||Flat process of drug coating for stents|
|US7959671||Nov 20, 2003||Jun 14, 2011||Merit Medical Systems, Inc.||Differential covering and coating methods|
|US7976648||Nov 2, 2000||Jul 12, 2011||Abbott Cardiovascular Systems Inc.||Heat treatment for cold worked nitinol to impart a shape setting capability without eventually developing stress-induced martensite|
|US7985440||Sep 7, 2005||Jul 26, 2011||Advanced Cardiovascular Systems, Inc.||Method of using a mandrel to coat a stent|
|US7985441||May 4, 2006||Jul 26, 2011||Yiwen Tang||Purification of polymers for coating applications|
|US8003156||May 4, 2006||Aug 23, 2011||Advanced Cardiovascular Systems, Inc.||Rotatable support elements for stents|
|US8007856||Oct 26, 2009||Aug 30, 2011||Advanced Cardiovascular Systems, Inc.||Mounting assembly for a stent and a method of using the same to coat a stent|
|US8017237||Jun 23, 2006||Sep 13, 2011||Abbott Cardiovascular Systems, Inc.||Nanoshells on polymers|
|US8020275||Nov 16, 2006||Sep 20, 2011||The Cleveland Clinic Foundation||Method for compressing intraluminal prostheses|
|US8042485||Dec 30, 2003||Oct 25, 2011||Advanced Cardiovascular Systems, Inc.||Stent mandrel fixture and method for coating stents|
|US8042487||Jan 14, 2008||Oct 25, 2011||Advanced Cardiovascular Systems, Inc.||System for coating stents|
|US8048441||Jun 25, 2007||Nov 1, 2011||Abbott Cardiovascular Systems, Inc.||Nanobead releasing medical devices|
|US8048448||Jun 15, 2006||Nov 1, 2011||Abbott Cardiovascular Systems Inc.||Nanoshells for drug delivery|
|US8051798||Jan 27, 2010||Nov 8, 2011||Advanced Cardiovascular Systems, Inc.||Mounting assembly for a stent and a method of using the same to coat a stent|
|US8067055||Mar 23, 2007||Nov 29, 2011||Biosensors International Group, Ltd.||Drug-delivery endovascular stent and method of use|
|US8069814||May 4, 2006||Dec 6, 2011||Advanced Cardiovascular Systems, Inc.||Stent support devices|
|US8104427||Aug 3, 2009||Jan 31, 2012||Boston Scientific Scimed, Inc.||Stent coating device|
|US8147538||Jan 15, 2008||Apr 3, 2012||Boston Scientific Scimed, Inc.||Covered stent|
|US8182522||Nov 16, 2006||May 22, 2012||The Cleveland Clinic Foundation||Apparatus and method for delivering lined intraluminal prostheses|
|US8187661||Aug 18, 2008||May 29, 2012||Advanced Cardiovascular Systems, Inc.||Stent support assembly and coating method|
|US8197879||Jan 16, 2007||Jun 12, 2012||Advanced Cardiovascular Systems, Inc.||Method for selectively coating surfaces of a stent|
|US8206436||Nov 11, 2009||Jun 26, 2012||Merit Medical Systems, Inc.||Coated stent with geometry determinated functionality and method of making the same|
|US8231929||Oct 23, 2007||Jul 31, 2012||Cook Medical Technologies Llc||Medical device coating process|
|US8236048||Apr 27, 2004||Aug 7, 2012||Cordis Corporation||Drug/drug delivery systems for the prevention and treatment of vascular disease|
|US8252047||Feb 8, 2011||Aug 28, 2012||Biosensors International Group, Ltd.||Drug-delivery endovascular stent and method for treating restenosis|
|US8263169||Oct 6, 2008||Sep 11, 2012||Advanced Cardiovascular Systems, Inc.||Stent mandrel fixture and method for reducing coating defects|
|US8267987||Sep 17, 2009||Sep 18, 2012||Merit Medical Systems, Inc.||Medical appliance delivery apparatus and method of use|
|US8293367||Jul 15, 2011||Oct 23, 2012||Advanced Cardiovascular Systems, Inc.||Nanoshells on polymers|
|US8298277||Nov 12, 2009||Oct 30, 2012||Merit Medical Systems, Inc.||Medical appliance optical delivery and deployment apparatus and method|
|US8303609||Sep 28, 2001||Nov 6, 2012||Cordis Corporation||Coated medical devices|
|US8312837||Jul 28, 2008||Nov 20, 2012||Advanced Cardiovascular Systems, Inc.||Support assembly for stent coating|
|US8349388||Mar 18, 2004||Jan 8, 2013||Advanced Cardiovascular Systems, Inc.||Method of coating a stent|
|US8359998||Jun 14, 2010||Jan 29, 2013||Boston Scientific Scimed Inc.||Stent coating apparatus and method|
|US8465789||Jul 18, 2011||Jun 18, 2013||Advanced Cardiovascular Systems, Inc.||Rotatable support elements for stents|
|US8592036||Sep 20, 2012||Nov 26, 2013||Abbott Cardiovascular Systems Inc.||Nanoshells on polymers|
|US8596215||Jul 18, 2011||Dec 3, 2013||Advanced Cardiovascular Systems, Inc.||Rotatable support elements for stents|
|US8603530||Jun 14, 2006||Dec 10, 2013||Abbott Cardiovascular Systems Inc.||Nanoshell therapy|
|US8637110||Jul 18, 2011||Jan 28, 2014||Advanced Cardiovascular Systems, Inc.||Rotatable support elements for stents|
|US8689729||Jan 4, 2008||Apr 8, 2014||Abbott Cardiovascular Systems Inc.||Apparatus for coating stents|
|US8695530 *||Jun 28, 2012||Apr 15, 2014||Cook Medical Technologies Llc||Medical device coating process|
|US8741379||Jul 18, 2011||Jun 3, 2014||Advanced Cardiovascular Systems, Inc.||Rotatable support elements for stents|
|US8791171||Jan 31, 2008||Jul 29, 2014||Abbott Cardiovascular Systems Inc.||Biodegradable coatings for implantable medical devices|
|US8808342||Apr 23, 2013||Aug 19, 2014||Abbott Cardiovascular Systems Inc.||Nanoshell therapy|
|US8828077||May 6, 2011||Sep 9, 2014||Medinol Ltd.||Flat process of preparing drug eluting stents|
|US8871292||Jul 24, 2012||Oct 28, 2014||Biosensors International Group, Ltd.||Drug-delivery endovascular stent and method for treating restenosis|
|US9028859||Jul 7, 2006||May 12, 2015||Advanced Cardiovascular Systems, Inc.||Phase-separated block copolymer coatings for implantable medical devices|
|US20030073961 *||Sep 28, 2001||Apr 17, 2003||Happ Dorrie M.||Medical device containing light-protected therapeutic agent and a method for fabricating thereof|
|US20030153971 *||Feb 14, 2002||Aug 14, 2003||Chandru Chandrasekaran||Metal reinforced biodegradable intraluminal stents|
|US20030153972 *||Feb 14, 2002||Aug 14, 2003||Michael Helmus||Biodegradable implantable or insertable medical devices with controlled change of physical properties leading to biomechanical compatibility|
|US20030207019 *||Jul 30, 2002||Nov 6, 2003||Avraham Shekalim||Stent coating device|
|US20030207020 *||Apr 22, 2003||Nov 6, 2003||Villareal Plaridel K.||Stent mounting device and a method of using the same to coat a stent|
|US20040058084 *||Sep 15, 2003||Mar 25, 2004||Labcoat Ltd.||Stent coating device|
|US20040060508 *||Sep 12, 2003||Apr 1, 2004||Pacetti Stephen D.||Stent mounting device|
|US20040062853 *||Oct 2, 2003||Apr 1, 2004||Pacetti Stephen D.||Mandrel for supporting a stent and a method of using the mandrel to coat a stent|
|US20040181278 *||Mar 24, 2004||Sep 16, 2004||Scimed Life Systems, Inc.||Polymer coated stent|
|US20040187775 *||Apr 2, 2004||Sep 30, 2004||Cameron Kerrigan||Coupling device for a stent support fixture|
|US20040191405 *||Apr 2, 2004||Sep 30, 2004||Cameron Kerrigan||Stent mandrel fixture and method for minimizing coating defects|
|US20040243214 *||Apr 20, 2004||Dec 2, 2004||Medtronic Vascular, Inc.||Coated stent with protective packaging and method of using same|
|US20050048194 *||Sep 2, 2003||Mar 3, 2005||Labcoat Ltd.||Prosthesis coating decision support system|
|US20050058768 *||Sep 16, 2003||Mar 17, 2005||Eyal Teichman||Method for coating prosthetic stents|
|US20050096730 *||Nov 24, 2004||May 5, 2005||Villareal Plaridel K.||Stent mounting device and a method of using the same to coat a stent|
|US20050131527 *||Dec 7, 2004||Jun 16, 2005||Pathak Chandrashekhar P.||Implantable medical devices with fluorinated polymer coatings, and methods of coating thereof|
|US20050241577 *||Jul 11, 2005||Nov 3, 2005||Labcoat, Ltd.||Stent coating device|
|US20050261764 *||Sep 12, 2003||Nov 24, 2005||Pacetti Stephen D||Method of using a stent mounting device to coat a stent|
|US20060069427 *||Sep 22, 2005||Mar 30, 2006||Savage Douglas R||Drug-delivery endovascular stent and method for treating restenosis|
|US20060073265 *||Nov 5, 2004||Apr 6, 2006||Eyal Teichman||Method and apparatus for coating a medical device|
|US20060156976 *||Mar 21, 2006||Jul 20, 2006||Labcoat, Ltd.||Stent coating device|
|US20070199360 *||Nov 16, 2006||Aug 30, 2007||The Cleveland Clinic Foundation||Method and apparatus for compressing intraluminal prostheses|
|US20080097568 *||Mar 23, 2007||Apr 24, 2008||Savage Douglas R||Drug-delivery endovascular stent and method of use|
|US20080097591 *||May 21, 2007||Apr 24, 2008||Biosensors International Group||Drug-delivery endovascular stent and method of use|
|US20080103584 *||Mar 29, 2007||May 1, 2008||Biosensors International Group||Temporal Intraluminal Stent, Methods of Making and Using|
|US20080103588 *||Jan 4, 2008||May 1, 2008||Advanced Cardiovascular Systems, Inc.||Method for coating stents|
|US20080107795 *||Jan 14, 2008||May 8, 2008||Hossainy Syed F||Method for Coating Stents|
|US20080110396 *||Jan 14, 2008||May 15, 2008||Hossainy Syed F||System for Coating Stents|
|US20080114447 *||Jan 15, 2008||May 15, 2008||Boston Scientific Scimed, Inc.||Covered stent|
|US20080124452 *||Feb 1, 2008||May 29, 2008||Arkady Kokish||Method for reducing stent coating defects|
|US20080175980 *||Oct 23, 2007||Jul 24, 2008||Jichao Sun||Medical Device Coating Process|
|US20080276866 *||Jul 28, 2008||Nov 13, 2008||Madriaga Domingo S||Support Assembly for Stent Coating|
|US20080305242 *||Aug 18, 2008||Dec 11, 2008||Madriaga Domingo S||Stent Support Assembly and Coating Method|
|US20090030508 *||Oct 6, 2008||Jan 29, 2009||Advanced Cardiovascular Systems Inc.||Stent Mandrel Fixture And Method For Reducing Coating Defects|
|US20090030509 *||Oct 6, 2008||Jan 29, 2009||Advanced Cardiovascular Systems Inc.||Stent Mandrel Fixture And Method For Reducing Coating Defects|
|US20090053393 *||Oct 6, 2008||Feb 26, 2009||Advanced Cardiovascular Systems Inc.||Stent Mandrel Fixture And Method For Reducing Coating Defects|
|US20090062903 *||Nov 7, 2008||Mar 5, 2009||C. R. Bard, Inc.||Implantable medical devices with fluorinated polymer coatings, and methods of coating thereof|
|US20090064930 *||Aug 12, 2008||Mar 12, 2009||Labcoat, Ltd.||Stent coating device|
|US20090149568 *||Jan 31, 2008||Jun 11, 2009||Abbott Cardiovascular Systems Inc.||Biodegradable Coatings For Implantable Medical Devices|
|US20090288597 *||Aug 3, 2009||Nov 26, 2009||Labcoat, Ltd.||Stent Coating Device|
|US20100098834 *||Oct 26, 2009||Apr 22, 2010||Advanced Cardiovascular Systems, Inc.||Mounting assembly for a stent and a method of using the same to coat a stent|
|US20100101295 *||Oct 28, 2008||Apr 29, 2010||Warsaw Orthopedic, Inc.||Isulated sheath for bending polymer-based rod|
|US20100125329 *||Dec 19, 2002||May 20, 2010||Zhi Cheng Lin||Pseudoelastic stents having a drug coating and a method of producing the same|
|US20100126414 *||Jan 27, 2010||May 27, 2010||Abbott Cardiovascular Systems, Inc.||Mounting Assembly For A Stent And A Method Of Using The Same To Coat A Stent|
|US20100154705 *||Mar 3, 2010||Jun 24, 2010||Pacetti Stephen D||System for Coating a Tubular Implantable Medical Device|
|US20100242840 *||Jun 14, 2010||Sep 30, 2010||Boston Scientific Scimed, Inc.||Stent Coating Apparatus and Method|
|US20100323092 *||Aug 10, 2010||Dec 23, 2010||Boston Scientific Scimed, Inc.||Stent Coating Device|
|US20110112629 *||Jan 20, 2011||May 12, 2011||C. R. Bard, Inc.||Implantable medical devices with fluorinated polymer coatings, and methods of coating thereof|
|US20110271904 *||Jul 18, 2011||Nov 10, 2011||Jason Van Sciver||Rotatable support elements for stents|
|US20110287403 *||May 21, 2010||Nov 24, 2011||Ciccone Ii William||Graft Tensioning Device|
|US20120282392 *||Jun 28, 2012||Nov 8, 2012||Cook Medical Technologies Llc||Medical device coating process|
|EP0997116A2 *||Oct 25, 1999||May 3, 2000||Medinol Ltd.||Balloon expandable covered stents|
|EP1470831A1 *||Apr 23, 2004||Oct 27, 2004||Medtronic Vascular, Inc.||Coated stent with protective packaging and method of using same|
|EP1723938A2 *||Jul 18, 2003||Nov 22, 2006||Boston Scientific Limited||Stent coating holders|
|EP2020265A1||May 1, 2003||Feb 4, 2009||Labcoat, Ltd.||Stent coating device|
|EP2045019A2||Nov 2, 2005||Apr 8, 2009||Labcoat, Ltd.||Method and apparatus for coating a stent|
|WO2001026582A1||Oct 5, 2000||Apr 19, 2001||Jan Otto Solem||Covered stent and method of making it|
|WO2001052772A1 *||Jan 18, 2001||Jul 26, 2001||The Government Of The United States Of America, As Represented By The Secretary, Department Of Health_Human Servicesthe National Institutes Of Health||Method and apparatus for coating an endoprosthesis|
|WO2003092909A1||May 1, 2003||Nov 13, 2003||Labcoat Ltd.||Stent coating device|
|WO2006012060A3 *||Jun 17, 2005||Jun 18, 2009||Conor Medsystems Inc||Methods and systems for loading an implantable medical device with beneficial agent|
|WO2007061801A2 *||Nov 16, 2006||May 31, 2007||The Cleveland Clinic Foundation||Method and apparatus for compressing intraluminal prostheses|
|WO2007061801A3 *||Nov 16, 2006||Nov 8, 2007||Cleveland Clinic Foundation||Method and apparatus for compressing intraluminal prostheses|
|WO2008130387A2 *||Nov 7, 2007||Oct 30, 2008||Med Institute, Inc.||Medical device coating process|
|WO2008130387A3 *||Nov 7, 2007||Feb 12, 2009||Med Inst Inc||Medical device coating process|
|U.S. Classification||427/2.3, 427/2.28, 427/2.25|
|International Classification||A61F2/82, B29C41/20, B29C31/00, B29C41/14, A61F2/00|
|Cooperative Classification||B29C41/20, B29C31/002, A61F2002/91525, A61F2220/005, A61F2002/91533, A61F2220/0075, A61F2002/9155, A61F2/0077, A61F2/07, A61F2/91, A61F2002/91558, A61F2/95, A61F2/958, A61F2002/828, A61F2002/072, B29C41/14, A61F2/915|
|European Classification||A61F2/91, A61F2/915, B29C31/00B, B29C41/14, B29C41/20|
|Aug 30, 1999||AS||Assignment|
Owner name: IOWA-INDIA INVESTMENTS COMPANY LIMITED, ISLE OF MA
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:JAYARAMAN, SWAMINATHAN;REEL/FRAME:010197/0501
Effective date: 19990823
|Mar 4, 2002||AS||Assignment|
Owner name: VASCULAR CONCEPTS HOLDINGS LIMITED, ISLE OF MAN
Free format text: CHANGE OF NAME;ASSIGNOR:IOWA-INDIA INVESTMENTS COMPANY LIMITED;REEL/FRAME:013029/0900
Effective date: 20020219
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