|Publication number||US6033362 A|
|Application number||US 08/845,333|
|Publication date||Mar 7, 2000|
|Filing date||Apr 25, 1997|
|Priority date||Apr 25, 1997|
|Also published as||CA2286272A1, CA2286272C, DE69830650D1, DE69830650T2, EP0964646A1, EP0964646B1, WO1998048704A1|
|Publication number||08845333, 845333, US 6033362 A, US 6033362A, US-A-6033362, US6033362 A, US6033362A|
|Original Assignee||Beth Israel Deaconess Medical Center|
|Export Citation||BiBTeX, EndNote, RefMan|
|Patent Citations (51), Non-Patent Citations (74), Referenced by (100), Classifications (14), Legal Events (5)|
|External Links: USPTO, USPTO Assignment, Espacenet|
Numerous devices have been used to position tissue at a surgical site to aid in the performing of surgical procedures. Retractors, for example, have been used to hold an artery in position during operations adjacent to the heart to prevent movement of the artery. This serves to minimize the risk of injury to the artery and adjacent tissue and can facilitate the desired anastomosis.
A recently developed procedure, referred to as the minimally invasive direct coronary artery bypass procedure, has been used to graft onto a coronary artery without cardiopulmonary bypass. This procedure involves the grafting of the left internal mammary artery (LIMA) onto the left anterior descending (LAD) or other artery. As this procedure does not require the use of a heart lung machine to oxygenate and pump blood, the morbidity and mortality associated with this procedure is substantially lower than previous bypass techniques. A problem associated with the minimally invasive procedure, however, is that while the heart continues to pump during the procedure, the motion of the heart can interfere with the surgeon's task of attaching the LIMA to the LAD. There is also a need to stop blood flow in the area of the graft to maintain a clear field of view and provide precise suture placement.
Two basic strategies have been employed to address the problem of operating on a moving site, one being the use of pharmacological agents to limit heart motion, and the other being mechanical, such as a two prong retractor that is pushed down against the heart on both sides of the artery, or alternatively, upward traction away from the moving heart by traction tape or suture thread. Both of these options, however, have problems associated with them. Both options are susceptible to some movement of the vessel grafting site. The use of pharmacological agents is undesirable and impairs circulatory function. Traction by compression of the heart against the spine does serve to immobilize the site but can compromise the ability of the heart to maintain circulation and result in hypotension. Upward traction can involve circumferential compression of the artery to occlude the artery and prevent blood flow, however upward traction that is sufficient to immobilize the site can cause injury, stenosis or occlusion of the vessel.
There is a continuing need however for improvement in devices and methods for retaining tissue at surgical sites to further reduce the risks associated with surgical procedures where the devices and methods are inexpensive, safe and reliable.
The present invention relates to a surgical retractor for immobilizing tissue at a surgical site and to a method of using the retractor during a surgical procedure. A preferred embodiment of the retractor includes a retaining element having an aperture that exposes the surgical site and a holder that is used to position tissue at the surgical site relative to the retaining element. A handle can be attached to or fabricated with the retaining element or platform so that the user can manipulate the position of the retractor as needed.
In a preferred embodiment of the invention a connector such as elastic tape or thread is used to position tissue at the surgical site within the retractor aperture and to prevent movement of the tissue during the procedure. The connecting cord, thread or tape also aids in the compression of the artery in a grafting procedure to occlude flow on one or both sides of the surgical site. The cord is attached to the holder on the retaining element. A preferred embodiment of the holder can be a plurality of slits or openings positioned on both sides of the retractor that receive and frictionally secure the cord on both sides of the aperture. In another preferred embodiment a mechanical fastener is used to grip both sides of the cord. The fastener can be a spring mounted valve, for example, that allows the user to adjust the tension in the cord.
A preferred embodiment of the invention comprises a retaining element or base having two sections that can be separated after the procedure is complete to permit removal of the retractor from under the grafted artery. Another preferred embodiment uses a side opening in the platform of the retractor that extends to the aperture so that the grafted artery slips through the side opening during removal. During minimally invasive direct coronary artery bypass operations, one or more surface sections of the retractor platform can be positioned against the inner surface or posterior aspect of one or both ribs adjacent to the surgical site. Thus, the size and geometry of the platform are selected to utilize the adjoining ribs where the upper surface of the platform frictionally engages the inner surface one or more ribs to hold the retractor in a fixed position. The retractor can be beneficial in any procedure where it is necessary to stabilize a surgical site. For example, the retractor can also be used for grafting onto the diagonal, right or other coronary arteries without altering the heart's pumping function.
The coronary arteries are about 1-2 mm in diameter, and the pumping heart can move these arteries over distances of several millimeters during each heartbeat. As the movement of even 1 or 2 millimeters can result in a displacement of the grafting site that can substantially interfere with effective anastomosis, it is desirable to restrain movement of the artery at the surgical site in any direction to less than 1 mm. The retractor of the present invention restrains movement in the plane of the base to less than 0.5 mm, and preferably less than 0.2 mm.
In a preferred embodiment of the invention, the handle or articulating arm that is secured to the platform can be held in position by the user, attached to a frame that is fixed around the operative site or simply clipped to a drape around the site.
When used in a minimally invasive coronary bypass procedure, the retractor is positioned to expose the left anterior descending (LAD) artery grafting site after incision, removal of the rib section and dissection of the left internal mammary artery (LIMA) from the chest wall. A pair of cords, for example, sialastic tape (i.e. a silicon elastomer) or suture thread, are passed through the myocardium at two locations flanking the artery grafting site with blunt needles. The four ends of the two cords are connected to the platform holder with sufficient tension to occlude blood flow on both sides of the operative site. The tapes compress the artery against the bottom surface of the platform while they hold the artery grafting site in a fixed position relative to the aperture. The coronary artery is opened longitudinally and the end of the mammary artery is sewn to the graft opening with multiple fine sutures. The cords are released, blood flow is restored and the anastomosis is inspected for hemostatis and other defects and the wound is closed.
FIG. 1 is a perspective view of a surgical retractor in accordance with a preferred embodiment of the invention.
FIG. 2 is a perspective view of a surgical site illustrating a surgical procedure.
FIG. 3 is a perspective view of a surgical retractor for a grafting procedure in accordance with the invention.
FIG. 4 is a bottom perspective view of a surgical retractor in accordance with the invention.
FIG. 5 is a cross-sectional view of a surgical retractor during a surgical procedure.
FIGS. 6A and 6B are partial cross-sectional views of a holder in accordance with the invention.
FIG. 7 is a top view of a two piece retainer in accordance with the invention.
FIG. 8 is a top perspective view of another preferred embodiment of a surgical retractor in accordance with the invention.
FIG. 9 is a top perspective view of another preferred embodiment of a surgical retractor in accordance with the invention.
FIG. 10 is a schematic diagram illustrating a surgical procedure in accordance with the invention.
A preferred embodiment of the invention is illustrated in connection with FIG. 1. A retractor 10 includes a retaining element or base 12 having an aperture 16 that is positioned to expose tissue at a surgical site. The base 12 can be made with a metal or a molded plastic material. The retractor 10 can be sterilized after each use, or alternatively, can be disposable after one procedure. A handle 30 or articulating arm can be permanently attached to the base 12, or as described below in connection with other preferred embodiments, can be detachable.
A suction tube 32 can be attached to the handle 30 or integrated therein and is used to remove material such as blood from the operative site. In this particular embodiment the tube 32 is connected at one end to a tube 34 from a suction pump and connected at a second end to a port 36 in fluid communication with a channel within tube 28 that extends around the periphery of base 12. The peripheral tube can have small openings 38 positioned on the sides or top thereof through which fluid such as blood or other debris can be suctioned from the surgical site to maintain a clear field.
A preferred embodiment of the invention can be used at a surgical site 50 such as the example illustrated in FIG. 2. In this particular procedure for a coronary graft without cardiopulmonary bypass, a section of the 4th costal cartilage or rib 56 is removed at 66 to expose a section of the LAD artery 61.
A proximal portion of the LIMA 62 is dissected from the chest wall to expose an end 65 to be grafted onto a grafting site 60 on artery 61. Blood flow in vessel 62 can be occluded with a clamp 64.
In this example, a connector such as a pair of cords or sialastic tapes 70, 72 are threaded through myocardium surface 78 under the artery 61 at two locations 74, 76 on opposite sides of the grafting site 60. Note that the exposed surface 78 of heart 52 is undergoing substantial movement during the procedure.
As seen in the reverse perspective view of FIG. 3 in which the retractor 10 has been inserted and positioned during the procedure, the retractor 10 serves to immobilize the grafting site 60 using connecting tapes 70, 72 which are stretched and attached to a holder mechanism including slots 20a-20d in the peripheral edge of base 12. As described in greater detail below, the slots 20A-20d can be manually opened or closed using actuators 22a-22d, respectively, to allow the user to adjust the tension in the tapes or threads.
The aperture 16 extends longitudinally along the axis of artery 61. The site 60 is preferably located in the plane of the upper surface of base 12. The tapes 70, 72 exert a compressive force on the artery 61 which is pressed against a bottom surface 40 as seen in FIG. 4. More particularly, the tapes 70, 72 extend in a direction that is substantially perpendicular to the artery 61 axis exposed in the aperture 16. The aperture can have a first pair of lateral sections 18a and 18b which are aligned to accommodate the positioning of tape 70 and the aperture can also have a second pair of lateral sections 18c and 18d to accommodate the positioning of tape 72. Alternatively, holes extending through the base 12 that are separated from the aperture can be used. The holes are large enough to provide easy feed through and can be angled towards the bottom center to provide compression of the artery at lower tension of the cord.
The size of the aperture can be in the range of 1-3 cm in length and 5-15 mm in width. The aperture can be narrower in the center and wider at the opposite ends to accommodate the openings or sections 18a-18d.
Between each pair of sections 18a-18b and 18c-18d, a sidewall section of the aperture, namely tabs 24, 26 extend on opposite ends of aperture 16. The tapes 70, 72 compress respective portions of artery 61 on opposite sides of site 60 against tabs 26, 24. As seen in FIG. 4, those portions 42, 44 of the bottom surface 40 are in contact with artery 61 and compress it. The bottom surface that surrounds the artery and is in contact with the heart wall can be roughened or abraded to frictionally engage the heart wall around the artery and thereby locally restrict heart motion around the surgical site.
In a preferred embodiment of the invention opposite ends 82 and 84 can be positioned under adjacent ribs 54 and 58, respectively. This eliminates any substantial movement of the base 12 while the heart is pumping so that anastomosis 80 of the end 65 onto site 60 can be quickly completed. The opposite ends 82, 84 can be slightly raised relative to the plane of the remainder of the base 12 to provide a concave structure to enhance the frictional engagement of sections 82, 84 to ribs 54, 58, respectively. The platform has a substantially rectangular shape with each side having a length in the range between 3.5 cm and 6 cm. Thus the surface area of the platform is between 12 cm2 and 25 cm2, preferably between 14 cm2 and 20 cm2. This size fits readily in the incision between the ribs and can be positioned with both ends extending under the 3rd and 5th ribs. This structure exerts little downward force on the heart or upward force on the artery while immobilizing the artery at the surgical site. Also the anterior-posterior compression of the artery avoids trauma to the artery due to circumferential compression. By engaging the ribs, the retractor is self retaining providing for easier use and manipulation.
As seen in FIG. 5, the tape 76 under the bottom surface 94 of the tab 24 lifts the artery 60 to form an occlusion 86. This view also shows the optional channel 92 extending around the periphery of base 12 that is used to irrigate or suction around the site.
The fastening mechanism is illustrated in the partial cross-sectional views of FIGS. 6A and 6B. The closed position 110 is illustrated in FIG. 6A where spring 112 has expanded to move slot 116 in element 115 out of alignment with slot 114 in the outer tube. The cord 72 is displace and frictionally grasped by the sliding movement of element 115. The user can manually displace 118 to align slot 114 with slot 116 while compressing spring 112. In the "open" position 120, the cord 72 can be easily removed or pulled through to increase tension.
After the procedure is complete the retractor 10 needs to be removed from the site. In the embodiment of FIG. 1, the base 12 can be formed with two sections or plates 14a, 14b. As seen in FIG. 7, these components can be separated at joint 25 to allow removal of the retractor 10. The two halves 14a, 14b can be connected with a frictional tube section 96.
In the preferred embodiment illustrated in FIG. 8, the retractor 100 can have a plurality of handle attachment sites 102, 104, 106, 108 so that the user can attach the handle 105 at any site to provide the most convenient access to the aperture and facilitate immobilization of other arteries. The handle can alternatively be positioned between the two cords at an orthogonal angle relative to the aperture axis and extending above the top surface of the base.
In another preferred embodiment of the invention illustrated in the perspective view of FIG. 9, a retractor 140 has a handle 142, slots 144 located in the plane of the aperture 160 to secure the cords extending through lateral sections of the aperture (for example, sections 152, 154), end sections 162, 164 that engage the ribs 54, 58, tabs 148, 150 for compression of both sides of the artery at the site 60 and a side opening 146 so that the retractor can be removed.
In this embodiment, the LIMA slides out through opening 146 during removal of the retractor after completion of the procedure. This unitary retractor structure 140 can also include various features described previously in connection with the embodiment of FIG. 1 including the attached or integrated suction tube, the detachable handle, the irrigation or suction channel with ports or the mechanically actuated fasteners.
A preferred method of stabilizing tissue during a coronary bypass procedure 200 is illustrated in the process flow sequence of FIG. 10. A 5-8 cm sized incision is made over the 4th rib and a section of the 4th costal cartilage is removed 202. The LIMA is dissected from the chest wall 204 and divided distally. After blood flow assessment the LIMA can be temporarily closed with a spring loaded clip.
A self-retaining wound retractor is used to distract the edges of the incision and a "trap door" incision is made in the pericardium and the cut edge sewn to the skin to pull the pericardial sack and heart anteriorly. The LAD is exposed and a site suitable for anastomosis is selected for grafting 206. Tapes are inserted in the myocardium with blunt needles approximately 1-2 cm apart 208 and the retractor is inserted 210 with the tapes being pulled through the aperture and positioned in the lateral sections thereof. The tapes are connected to the holder 212 to compress the artery 214 and occlude blood flow on both sides of the grafting site. The tension in the tapes can optionally be adjusted during the procedure to minimize blood loss at the site.
The retractor is secured 216 at the site by positioning one or both ends under adjoining ribs, or alternatively, attaching the handle or arm to the wound retractor or other implement. The grafting site undergoes less than 0.1 mm of movement in any direction during this example procedure.
The site is suctioned or irrigated 218 during anastomosis, the grafting site is inspected, the tapes are released from the holders, and the retractor is removed either by sliding the LIMA through a side opening in the retractor or detaching a section of the retractor to accommodate removal of the LIMA from the aperture. After blood flow is restored, the site is inspected and closed 220.
Although the use of the retractor has been described in connection with a particular bypass procedure, it can also be used in other procedures such as bypass operations involving the diagonal, right or other coronary artery where movement at the site can interfere with the procedure.
Alternative embodiments involve opening of the chest and positioning the retractor at any exposed site on the heart wall or surrounding areas to immobilize the operative site. The retractor serves to isolate the site and limits or stops motion at the site due to respiratory movement of the lungs or the pumping motion of the heart.
While the invention has been described in connection with specific methods and apparatus, it is to be understood by those skilled in the art that the description is by way of example and not as a limitation on the scope of the invention as set forth in the appended claims.
|Cited Patent||Filing date||Publication date||Applicant||Title|
|US3983863 *||Jun 2, 1975||Oct 5, 1976||American Hospital Supply Corporation||Heart support for coronary artery surgery|
|US4151838 *||Jun 17, 1977||May 1, 1979||Crew John R||Internal mammary artery sternal retractor|
|US4366819 *||Nov 17, 1980||Jan 4, 1983||Kaster Robert L||Anastomotic fitting|
|US4368736 *||Nov 17, 1980||Jan 18, 1983||Kaster Robert L||Anastomotic fitting|
|US4461284 *||Sep 30, 1982||Jul 24, 1984||Fackler Martin L||Surgical retaining device|
|US4622955 *||Sep 5, 1985||Nov 18, 1986||Mehdi Fakhrai||Surgical retractor for dissection of internal mammary artery|
|US4637377 *||Sep 20, 1985||Jan 20, 1987||Loop Floyd D||Pillow or support member for surgical use|
|US4726356 *||Nov 12, 1985||Feb 23, 1988||Kapp Surgical Instrument, Inc.||Cardiovascular and thoracic retractor|
|US4973300 *||Sep 22, 1989||Nov 27, 1990||Pioneering Technologies, Inc.||Cardiac sling for circumflex coronary artery surgery|
|US4989587 *||Apr 26, 1989||Feb 5, 1991||Farley Daniel K||Sternal retractor|
|US5088472 *||Apr 4, 1990||Feb 18, 1992||Mehdi Fakhrai||Retractor|
|US5150706 *||Aug 15, 1991||Sep 29, 1992||Cox James L||Cooling net for cardiac or transplant surgery|
|US5167223 *||Sep 8, 1989||Dec 1, 1992||Tibor Koros||Heart valve retractor and sternum spreader surgical instrument|
|US5365921 *||Jan 22, 1993||Nov 22, 1994||Bookwalter John R||Flip-up sternal retractor|
|US5447515 *||Feb 8, 1994||Sep 5, 1995||Pilling Co.||Coronary bypass clamp|
|US5452733 *||Feb 22, 1993||Sep 26, 1995||Stanford Surgical Technologies, Inc.||Methods for performing thoracoscopic coronary artery bypass|
|US5501698 *||Feb 14, 1994||Mar 26, 1996||Heartport, Inc.||Endoscopic microsurgical instruments and methods|
|US5509890 *||Nov 14, 1994||Apr 23, 1996||Kazama; Shigeru||Heart retractor|
|US5569274 *||Jun 24, 1994||Oct 29, 1996||Heartport, Inc.||Endoscopic vascular clamping system and method|
|US5697891 *||Jan 6, 1997||Dec 16, 1997||Vista Medical Technologies, Inc.||Surgical retractor with accessory support|
|US5727569 *||Feb 20, 1996||Mar 17, 1998||Cardiothoracic Systems, Inc.||Surgical devices for imposing a negative pressure to fix the position of cardiac tissue during surgery|
|US5728151 *||Jun 5, 1995||Mar 17, 1998||Heartport, Inc.||Intercostal access devices for less-invasive cardiovascular surgery|
|US5730757 *||Feb 20, 1996||Mar 24, 1998||Cardiothoracic Systems, Inc.||Access platform for internal mammary dissection|
|US5749892 *||Jul 24, 1996||May 12, 1998||Heartport, Inc.||Device for isolating a surgical site|
|US5769870 *||Feb 20, 1996||Jun 23, 1998||Cardiothoracic Systems, Inc.||Perfusion device for maintaining blood flow in a vessel while isolating an anastomosis|
|US5776154 *||Feb 20, 1996||Jul 7, 1998||Cardiothoracic Systems, Inc.||Surgical instruments for making precise incisions in a cardiac vessel|
|US5782746 *||Feb 15, 1996||Jul 21, 1998||Wright; John T. M.||Local cardiac immobilization surgical device|
|US5871496 *||Apr 10, 1997||Feb 16, 1999||Cardiothoracic Systems, Inc.||Surgical instrument for facilitating the detachment of an artery and the like|
|US5875782 *||Nov 14, 1996||Mar 2, 1999||Cardiothoracic Systems, Inc.||Methods and devices for minimally invasive coronary artery revascularization on a beating heart without cardiopulmonary bypass|
|US5876332 *||Jul 24, 1997||Mar 2, 1999||Genzyme Corporation||Surgical support member|
|US5888247 *||Apr 10, 1995||Mar 30, 1999||Cardiothoracic Systems, Inc||Method for coronary artery bypass|
|US5891140 *||Dec 23, 1996||Apr 6, 1999||Cardiothoracic Systems, Inc.||Electrosurgical device for harvesting a vessel especially the internal mammary artery for coronary artery bypass grafting|
|US5894843 *||Feb 20, 1996||Apr 20, 1999||Cardiothoracic Systems, Inc.||Surgical method for stabilizing the beating heart during coronary artery bypass graft surgery|
|CA2216893A1 *||Sep 30, 1997||Feb 27, 1999||Raymond Cartier||Sternum retractor for performing bypass surgery on a beating heart|
|DE29707567U1 *||Apr 29, 1997||Jul 3, 1997||Riess Andreas G||Anordnung zum lokalen Ruhigstellen eines schlagenden Herzens|
|EP0336526A1 *||Jan 16, 1989||Oct 11, 1989||Steven J. Phillips||Retractor apparatus for use in harvesting mammary arteries during heart by-pass surgery|
|EP0356410A1 *||Aug 15, 1989||Feb 28, 1990||Mogens Bugge||A device intended to be used for opening the chest during surgery|
|EP0630629A1 *||May 17, 1994||Dec 28, 1994||Paul Hartmann Aktiengesellschaft||Hydrogel wound dressing product|
|EP0791330A2 *||Feb 20, 1997||Aug 27, 1997||Cardiothoracic Systems, Inc.||Surgical instruments and procedures for stabilizing the beating heart during coronary artery bypass graft surgery|
|EP0820721A1 *||Jul 25, 1997||Jan 28, 1998||Guidant Corporation||Epicardial immobilization device|
|FR1019217A *||Title not available|
|WO1987004081A1 *||Jan 8, 1987||Jul 16, 1987||Licencia Talalmanyokat||Electrode catheter for the ablation of the his bundle|
|WO1994014383A1 *||Dec 22, 1992||Jul 7, 1994||Laser Eng Inc||Handpiece for transmyocardial vascularization heart-synchronized pulsed laser system|
|WO1995015715A1 *||Nov 18, 1994||Jun 15, 1995||Stanford Surgical Technologies||Devices and methods for intracardiac procedures|
|WO1995017127A1 *||Apr 12, 1994||Jun 29, 1995||Oticon As||Method and instrument for establishing the receiving site of a coronary artery bypass graft|
|WO1996004854A1 *||Aug 4, 1995||Feb 22, 1996||Heartport Inc||Surgical knot pusher and method of use|
|WO1997010753A1 *||Sep 19, 1996||Mar 27, 1997||Cornelius Borst||Method and apparatus for temporarily immobilizing a local area of tissue|
|WO1997020524A1 *||Nov 18, 1996||Jun 12, 1997||Medtronic Inc||Physiologic mitral valve bioprosthesis|
|WO1997027807A1 *||Jan 24, 1997||Aug 7, 1997||Heartport Inc||Endoscopic suturing devices and methods|
|WO1998025549A1 *||Dec 10, 1997||Jun 18, 1998||Purdue Research Foundation||Artificial vascular valves|
|WO1999011201A2 *||Sep 4, 1998||Mar 11, 1999||Endocore Inc||Artificial chordae replacement|
|1||A Eguchi. "Heart Retractor for Use in Anastomosis in Coronary Artery By-Pass Surgery", Jap. J. Thorac. Surg. 40(1):1-2 (1987) English Summary.|
|2||*||A Eguchi. Heart Retractor for Use in Anastomosis in Coronary Artery By Pass Surgery , Jap. J. Thorac. Surg. 40 (1):1 2 (1987) English Summary.|
|3||Ancalmo et al., "A Modified Sternal Retractor", Dept. Surgery, Alton Ochsner Medical Foundation and Ochsner Clinic p. 174 (1975).|
|4||*||Ancalmo et al., A Modified Sternal Retractor , Dept. Surgery, Alton Ochsner Medical Foundation and Ochsner Clinic p. 174 (1975).|
|5||Angelini et al., "A Simple, Inexpensive Method of Heart Retraction During Coronary Artery Bypass Surgery", Ann Thorac Surg 46:246-247 (Aug. 1988).|
|6||*||Angelini et al., A Simple, Inexpensive Method of Heart Retraction During Coronary Artery Bypass Surgery , Ann Thorac Surg 46 :246 247 (Aug. 1988).|
|7||Arom et al., "Mini-Sternotomy for Coronary Artery Bypass Grafting", Ann Thorac Sur 61:1271-1272 (1996).|
|8||*||Arom et al., Mini Sternotomy for Coronary Artery Bypass Grafting , Ann Thorac Sur 61:1271 1272 (1996).|
|9||Badellino et al., "The Cardiac Rag", Simple Exposure to the Heart 15(2):114-135 (1988).|
|10||*||Badellino et al., The Cardiac Rag , Simple Exposure to the Heart 15 (2):114 135 (1988).|
|11||Bonatti et al., "Single Coronary Artery Bypass grafting--A Comparison Between Minimally Invasive `Off Pump` Techniques and Conventional Procedures", Euro J Cardo-thorac Sur 14(Suppl 1):S7-S12 (1998).|
|12||*||Bonatti et al., Single Coronary Artery Bypass grafting A Comparison Between Minimally Invasive Off Pump Techniques and Conventional Procedures , Euro J Cardo thorac Sur 14 (Suppl 1):S7 S12 (1998).|
|13||Borst, C. et al., "Coronary Artery Bypass Grafting Without Cardiopulmonary Bypass and Without Interruption of Native Coronary Flow Using a Novel Anastomosis Site Restraining Device ("Octopus")," JACC, 27(6):1356-1364 (1996).|
|14||*||Borst, C. et al., Coronary Artery Bypass Grafting Without Cardiopulmonary Bypass and Without Interruption of Native Coronary Flow Using a Novel Anastomosis Site Restraining Device ( Octopus ), JACC , 27(6):1356 1364 (1996).|
|15||Calafiore et al., "Minimally Invasive Coronary Artery Bypass Grafting", Ann Thorac Surg 62:1545-1548 (1996).|
|16||*||Calafiore et al., Minimally Invasive Coronary Artery Bypass Grafting , Ann Thorac Surg 62 :1545 1548 (1996).|
|17||Cartier et al., "Triple Coronary Artery Revascularization on the Stabilized Beating Heart: Initial Experience", CJS, 41(4):283-288 (Aug. 1998).|
|18||*||Cartier et al., Triple Coronary Artery Revascularization on the Stabilized Beating Heart: Initial Experience , CJS , 41(4):283 288 (Aug. 1998).|
|19||Chaux et al., "A New Concept in Sternal Retraction: Applications for Internal Mammary Artery Dissection and Valve Replacement Surgery", Ann Thorac Surg 42:473-474 (Oct. 1986).|
|20||*||Chaux et al., A New Concept in Sternal Retraction: Applications for Internal Mammary Artery Dissection and Valve Replacement Surgery , Ann Thorac Surg 42 :473 474 (Oct. 1986).|
|21||Cremer et al., "Off-Bypass Coronary Bypass Grafting via Minithoraceotomy Using Mechanical Epicardial Stabilization", Ann Thorac Surg, 63:S79-83 (1997).|
|22||*||Cremer et al., Off Bypass Coronary Bypass Grafting via Minithoraceotomy Using Mechanical Epicardial Stabilization , Ann Thorac Surg , 63:S79 83 (1997).|
|23||Cutler et al., "New Use for an Old Clamp", Arch Surg. 115:1136-1137, (Sep. 1980).|
|24||*||Cutler et al., New Use for an Old Clamp , Arch Surg. 115 :1136 1137, (Sep. 1980).|
|25||D. Cooley, "Limited Access Myocardial Revascularization", Texas Heart Ins. J. 23(2):81-84 (1996).|
|26||*||D. Cooley, Limited Access Myocardial Revascularization , Texas Heart Ins. J. 23 (2):81 84 (1996).|
|27||DelRossi, "A New Retractor to Aid in Coronary Artery Surgery", Ann Thorac Surg 36(1):101-102 (Jul. 1983).|
|28||*||DelRossi, A New Retractor to Aid in Coronary Artery Surgery , Ann Thorac Surg 36 (1):101 102 (Jul. 1983).|
|29||*||Editorial, Ann Thorac Surg 62 :1883 1892 (1996).|
|30||Editorial, Ann Thorac Surg 62:1883-1892 (1996).|
|31||F. Robicsek, "Aortic Sppon-Jaw Clamp for Aorto-Saphenous Vein Anastomosis", J. Card Surg 10:583-585 (1995).|
|32||*||F. Robicsek, Aortic Sppon Jaw Clamp for Aorto Saphenous Vein Anastomosis , J. Card Surg 10 :583 585 (1995).|
|33||Favaloro et al., "Direct Myocardial Revascularization by Saphenous Vein Graft", Ann Thorac Surg, 10(2):97-111 (Aug. 1970).|
|34||*||Favaloro et al., Direct Myocardial Revascularization by Saphenous Vein Graft , Ann Thorac Surg , 10(2):97 111 (Aug. 1970).|
|35||G. Green, "Technique of Internal Mammary--Coronary Artery Anastomosis", J. Thorac Cardiovasc Surg. 78:455-459 (1979).|
|36||*||G. Green, Technique of Internal Mammary Coronary Artery Anastomosis , J. Thorac Cardiovasc Surg. 78 :455 459 (1979).|
|37||Hasan et al., "Technique of Dissecting the Internal Mammary After Using the Moussalli Bar", Eur J. Cardo-thorac Surg 4:571-572 (1990).|
|38||*||Hasan et al., Technique of Dissecting the Internal Mammary After Using the Moussalli Bar , Eur J. Cardo thorac Surg 4 :571 572 (1990).|
|39||Kazama, et al., "Fabric Heart Retractor for Coronary Artery Bypass Operations", Ann Thorac Surg 55:1582-1583 (1993).|
|40||*||Kazama, et al., Fabric Heart Retractor for Coronary Artery Bypass Operations , Ann Thorac Surg 55 :1582 1583 (1993).|
|41||M. Bugge, "A New Internal Mammary Artery Retractor", Thorac. Cardio. Surg. 38:316-317 (1990).|
|42||*||M. Bugge, A New Internal Mammary Artery Retractor , Thorac. Cardio. Surg. 38 :316 317 (1990).|
|43||M. Vigano et al., "Applicazione dell'archetto di divaricamento vasale in corso di chirurgia coronarica", Min Cardioang 23(6-7):369-371 (1975) English Summary.|
|44||*||M. Vigano et al., Applicazione dell archetto di divaricamento vasale in corso di chirurgia coronarica , Min Cardioang 23 (6 7):369 371 (1975) English Summary.|
|45||Matsuura et al., "A New Device for Exposing the Circumflex Coronary Artery", Ann Thorac Surg 59:1249-1250 (1995).|
|46||*||Matsuura et al., A New Device for Exposing the Circumflex Coronary Artery , Ann Thorac Surg 59 :1249 1250 (1995).|
|47||McKeown et al., "A Modified Sternal Retractor for Exposure of the Internal Mammary Artery", Soc Thorac Sur (1980).|
|48||*||McKeown et al., A Modified Sternal Retractor for Exposure of the Internal Mammary Artery , Soc Thorac Sur (1980).|
|49||Murata et al., "Revascularization of the Circumflex Coronary Artery--A New Instrument and A Technical Method", Jap. J. Thorac. Surg. 42(2)115-119 (1989) English Summary.|
|50||*||Murata et al., Revascularization of the Circumflex Coronary Artery A New Instrument and A Technical Method , Jap. J. Thorac. Surg. 42 (2)115 119 (1989) English Summary.|
|51||Oschner et al., "Surgical Management of Diseased Intracavitary Coronary Arteries", Ann Thorac Surg 38(4):356-362 (Oct. 1984).|
|52||*||Oschner et al., Surgical Management of Diseased Intracavitary Coronary Arteries , Ann Thorac Surg 38 (4):356 362 (Oct. 1984).|
|53||Parsonnet et al., "Graduated Probes for Coronary Bypass Surgery", 68(3):424-427 (Sep. 1974).|
|54||Parsonnet et al., "Self-retraining Epicardial Retractor for Aortocoronary Bypass Surgery", J. Thorac Cardio Surg pp. 629-630 (1979).|
|55||*||Parsonnet et al., Graduated Probes for Coronary Bypass Surgery , 68(3):424 427 (Sep. 1974).|
|56||*||Parsonnet et al., Self retraining Epicardial Retractor for Aortocoronary Bypass Surgery , J. Thorac Cardio Surg pp. 629 630 (1979).|
|57||Perrault, et al., "Snaring of the Target Vessel in Less Invasive Bypass Operations Does Not Cause Endothelial Dysfunction", Ann Thorac Surg, 63:751-755 (1997).|
|58||*||Perrault, et al., Snaring of the Target Vessel in Less Invasive Bypass Operations Does Not Cause Endothelial Dysfunction , Ann Thorac Surg , 63:751 755 (1997).|
|59||Phillips et al., "A Versatile Retractor for use in Harvesting the Internal Mammary Artery and Performing Standard Cardiac Operations", J. Thorac Cardiovasc Surg 97:633-635 (1989).|
|60||*||Phillips et al., A Versatile Retractor for use in Harvesting the Internal Mammary Artery and Performing Standard Cardiac Operations , J. Thorac Cardiovasc Surg 97 :633 635 (1989).|
|61||Pittman, et al., "Improved Visualization of the Internal Mammary Artery With a New Retractor System", Ann Thorac Surg 48:869-870 (1989).|
|62||*||Pittman, et al., Improved Visualization of the Internal Mammary Artery With a New Retractor System , Ann Thorac Surg 48 :869 870 (1989).|
|63||Rousou et al., "Cardiac Retractor for Coronary Bypass Operations", Ann Thorac Surg 52:877-878 (1991).|
|64||*||Rousou et al., Cardiac Retractor for Coronary Bypass Operations , Ann Thorac Surg 52 :877 878 (1991).|
|65||Roux et al., "Internal Mammary Artery Dissection: A Three Dimensional Sternal Retractor", J. Cardiovasc. Surg., 30:996-997 (1989).|
|66||Roux et al., "New Helper Instrument in Cardiac Surgery", Ann Thorac Surg 48:595-596 (1989).|
|67||*||Roux et al., Internal Mammary Artery Dissection: A Three Dimensional Sternal Retractor , J. Cardiovasc. Surg. , 30:996 997 (1989).|
|68||*||Roux et al., New Helper Instrument in Cardiac Surgery , Ann Thorac Surg 48 :595 596 (1989).|
|69||S. Eguchi, "A special Retractor for Stabilizing the Heart During Circumflex Coronary Grafting", Dept. Surg Niiagata Univ. Sch. Med. pp. 39-40 (1987) English Summary.|
|70||*||S. Eguchi, A special Retractor for Stabilizing the Heart During Circumflex Coronary Grafting , Dept. Surg Niiagata Univ. Sch. Med. pp. 39 40 (1987) English Summary.|
|71||Stephen Westaby, Editorial, "Coronary Surgery Without Cardiopulmonary Bypass", Br. Heart J., 73:203-205 (1995).|
|72||*||Stephen Westaby, Editorial, Coronary Surgery Without Cardiopulmonary Bypass , Br. Heart J. , 73:203 205 (1995).|
|73||Westaby et al., "Less Invasive Coronary Surgery: Consensus From the Oxford Meeting", Ann Thorac Surg 62:924-931 (1996).|
|74||*||Westaby et al., Less Invasive Coronary Surgery: Consensus From the Oxford Meeting , Ann Thorac Surg 62 :924 931 (1996).|
|Citing Patent||Filing date||Publication date||Applicant||Title|
|US6231506||May 4, 1999||May 15, 2001||Cardiothoracic Systems, Inc.||Method and apparatus for creating a working opening through an incision|
|US6241655 *||Oct 15, 1999||Jun 5, 2001||Andreas G. Riess||Device for locally immobilizing a beating heart|
|US6283912||May 4, 1999||Sep 4, 2001||Cardiothoracic Systems, Inc.||Surgical retractor platform blade apparatus|
|US6290644 *||May 4, 1999||Sep 18, 2001||Cardiothoracic Systems, Inc.||Surgical instruments and procedures for stabilizing a localized portion of a beating heart|
|US6315717||Apr 17, 2000||Nov 13, 2001||Cardiothoracic Systems, Inc.||Surgical instruments for stabilizing the beating heart during coronary artery bypass graft surgery|
|US6331158||May 4, 1999||Dec 18, 2001||Cardiothoracic Systems, Inc.||Surgical retractor apparatus for operating on the heart through an incision|
|US6361493 *||Nov 16, 1999||Mar 26, 2002||Origin Medsystems, Inc.||Device to permit offpump beating heart coronary bypass surgery|
|US6364833 *||Jan 12, 2000||Apr 2, 2002||Genzyme Corpforation||Irrigator for use with surgical retractor and tissue stabilization device and methods related thereto|
|US6394951||Mar 13, 2000||May 28, 2002||Cardiothoracic Systems, Inc.||Surgical instruments and procedures for stabilizing the beating heart during coronary artery bypass graft surgery|
|US6406424||Sep 16, 1999||Jun 18, 2002||Williamson, Iv Warren P.||Tissue stabilizer having an articulating lift element|
|US6458079 *||Oct 1, 1999||Oct 1, 2002||Beth Israel Deaconess Medical Center||Surgical retractor and method of use|
|US6464629||Sep 15, 1999||Oct 15, 2002||Medtronic, Inc.||Method and apparatus for temporarily immobilizing a local area of tissue|
|US6464690||Oct 11, 2000||Oct 15, 2002||Popcab, Llc||Port off-pump beating heart coronary artery bypass heart stabilization system|
|US6478733 *||Apr 28, 2000||Nov 12, 2002||Genzyme Corporation||Stabilizing device having a removable portion|
|US6503245||Dec 8, 2000||Jan 7, 2003||Medcanica, Inc.||Method of performing port off-pump beating heart coronary artery bypass surgery|
|US6511416||Aug 3, 1999||Jan 28, 2003||Cardiothoracic Systems, Inc.||Tissue stabilizer and methods of use|
|US6592573||Jun 27, 2001||Jul 15, 2003||Popcab, Llc||Through-port heart stabilization system|
|US6610008||Sep 24, 2001||Aug 26, 2003||Origin Medsystems, Inc.||Device and method to permit offpump beating heart coronary bypass surgery|
|US6626830||Dec 1, 1999||Sep 30, 2003||Cardiothoracic Systems, Inc.||Methods and devices for improved tissue stabilization|
|US6652454||Jan 10, 2001||Nov 25, 2003||Lawrence W. Hu||Method and apparatus for creating a working opening through an incision|
|US6656113||May 25, 2001||Dec 2, 2003||Cardiothoracic System, Inc.||Surgical instruments and procedures for stabilizing a localized portion of a beating heart|
|US6673013||Apr 9, 2001||Jan 6, 2004||Cardiothoracic Systems, Inc.||Surgical instruments and procedures for stabilizing the beating heart during coronary artery bypass graft surgery|
|US6676597||Jun 12, 2001||Jan 13, 2004||Medtronic, Inc.||Method and device for organ positioning|
|US6685632||May 4, 2000||Feb 3, 2004||Cardiothoracic Systems, Inc.||Surgical instruments for accessing and stabilizing a localized portion of a beating heart|
|US6701930||Nov 6, 2001||Mar 9, 2004||Cardiothoracic Systems, Inc.|
|US6705988||Dec 28, 2001||Mar 16, 2004||Origin Medsystems, Inc.||Device to permit offpump beating heart coronary bypass surgery|
|US6726622||Dec 20, 2001||Apr 27, 2004||Origin Medsystems, Inc.||Device to permit offpump beating heart coronary bypass surgery|
|US6733443||May 18, 2001||May 11, 2004||Synthes (Usa)||Retraction plate for soft-tissue parts|
|US6740028||Mar 13, 2002||May 25, 2004||Medtronic, Inc.||Method and apparatus for temporarily immobilizing a local area of tissue|
|US6740029||Sep 5, 2002||May 25, 2004||Chase Medical, L.P.||Device and method for isolating a surface of a beating heart during surgery|
|US6743169||Oct 10, 2001||Jun 1, 2004||Cardiothoracic Systems, Inc.|
|US6743170||Sep 18, 2001||Jun 1, 2004||Cardiothoracic Systems, Inc.||Device to permit offpump beating heart coronary bypass surgery|
|US6752759||Apr 1, 2002||Jun 22, 2004||Thomas E. Martin||Cooled stabilizer for surgical procedures|
|US6758808||Jan 24, 2001||Jul 6, 2004||Cardiothoracic System, Inc.||Surgical instruments for stabilizing a localized portion of a beating heart|
|US7201716||Feb 18, 2004||Apr 10, 2007||Medtronic, Inc.||Method and apparatus for temporarily immobilizing a local area of tissue|
|US7235049 *||May 7, 1999||Jun 26, 2007||Beth Israel Deaconess Medical Center||Surgical retractor and method of positioning an artery during surgery|
|US7468030||Mar 6, 2000||Dec 23, 2008||Beth Israel Deaconess Medical Center||Surgical retractor|
|US7736307||Dec 12, 2003||Jun 15, 2010||Maquet Cardiovascular Llc||Surgical instruments for accessing and stabilizing a localized portion of a beating heart|
|US7736308||Sep 16, 2002||Jun 15, 2010||Teleflex-Ct Devices Incorporated||Surgical retractor|
|US7931590||Oct 29, 2002||Apr 26, 2011||Maquet Cardiovascular Llc||Tissue stabilizer and methods of using the same|
|US8083664||May 25, 2005||Dec 27, 2011||Maquet Cardiovascular Llc||Surgical stabilizers and methods for use in reduced-access surgical sites|
|US8105235 *||Jun 8, 2004||Jan 31, 2012||Intuitive Surgical Operations, Inc.||Stabilizer for robotic beating-heart surgery|
|US8162817||Dec 10, 2008||Apr 24, 2012||Maquet Cardiovascular Llc||Device to permit offpump beating heart coronary bypass surgery|
|US8277476||Oct 14, 2003||Oct 2, 2012||Maguet Cardiovascular LLC||Surgical instruments and procedures for stabilizing the beating heart during coronary artery bypass graft|
|US8317695||Dec 16, 2008||Nov 27, 2012||Maquet Cardiovascular Llc||Device to permit offpump beating heart coronary bypass surgery|
|US8449449||Dec 8, 2008||May 28, 2013||Medtronic, Inc.||Methods and apparatus providing suction-assisted tissue engagement through a minimally invasive incision|
|US8540628||Jan 13, 2011||Sep 24, 2013||Covidien Lp||Expandable thoracic access port|
|US8574155||Jan 13, 2011||Nov 5, 2013||Covidien Lp||Expandable surgical access port|
|US8579810||Jan 13, 2011||Nov 12, 2013||Covidien Lp||Expandable thoracic access port|
|US8597180||Jun 23, 2011||Dec 3, 2013||Covidien Lp||Expandable thoracic access port|
|US8641598||Dec 18, 2008||Feb 4, 2014||Maquet Cardiovascular Llc||Organ manipulator apparatus|
|US8734320||Mar 28, 2013||May 27, 2014||Medtronic, Inc.||Methods and apparatus providing suction-assisted tissue engagement through a minimally invasive incision|
|US8753266||Feb 7, 2007||Jun 17, 2014||Maquet Cardiovascular Llc||Device to permit offpump beating heart coronary bypass surgery|
|US8777849||Jan 13, 2011||Jul 15, 2014||Covidien Lp||Expandable thoracic access port|
|US8864658||Nov 16, 2011||Oct 21, 2014||Covidien Lp||Expandable surgical access port|
|US8870900||Mar 21, 2007||Oct 28, 2014||Intuitive Surgical Operations, Inc.||Endoscopic beating-heart stabilizer and vessel occlusion fastener|
|US8914150||Jan 24, 2014||Dec 16, 2014||Intuitive Surgical Operations, Inc.||Cooperative minimally invasive telesurgical system|
|US8961408 *||Nov 16, 2011||Feb 24, 2015||Covidien Lp||Expandable surgical access port|
|US8961409||Dec 6, 2012||Feb 24, 2015||Covidien Lp||Thoracic access assembly|
|US9022998||Feb 26, 2010||May 5, 2015||Maquet Cardiovascular Llc||Blower instrument, apparatus and methods of using|
|US9039610||Apr 12, 2012||May 26, 2015||Covidien Lp||Thoracic access port|
|US9039681||Jul 16, 2008||May 26, 2015||Intuitive Surgical Operations, Inc.||Minimally invasive surgical training using robotics and telecollaboration|
|US9119654||Jan 13, 2012||Sep 1, 2015||Intuitive Surgical Operations, Inc.||Stabilizer for robotic beating-heart surgery|
|US9119665||Feb 16, 2012||Sep 1, 2015||Covidien Lp||Thoracic access port including foldable anchor|
|US9168031||Oct 30, 2013||Oct 27, 2015||Covidien Lp||Expandable thoracic access port|
|US20020004628 *||Jul 6, 2001||Jan 10, 2002||Hu Lawrence W.||Surgical retractor platform blade apparatus|
|US20020111537 *||Mar 14, 2002||Aug 15, 2002||Taylor Charles S.|
|US20020165434 *||Apr 30, 2002||Nov 7, 2002||Williamson Warren P.||Tissue stabilizer having an articulating lift element|
|US20030013941 *||Sep 16, 2002||Jan 16, 2003||Beth Israel Deaconess Medical Center||Surgical Retractor|
|US20030094180 *||Jan 7, 2003||May 22, 2003||Benetti Frederico J.||Method for coronary artery bypass|
|US20040030223 *||Aug 7, 2003||Feb 12, 2004||Calafiore Antonio M.||Method and devices for improved tissue stabilization|
|US20040082830 *||Nov 19, 2003||Apr 29, 2004||Guenst Gary W.||Device for organ positioning|
|US20040087834 *||Oct 29, 2003||May 6, 2004||Benetti Federico J.|
|US20040092798 *||Oct 31, 2003||May 13, 2004||Spence Paul A.||Device to permit offpump beating heart coronary bypass surgery|
|US20040092799 *||Sep 23, 2003||May 13, 2004||Hu Lawrence W.||Method and apparatus for creating a working opening through an incision|
|US20040138522 *||Sep 30, 2003||Jul 15, 2004||Haarstad Philip J.||Methods and apparatus providing suction-assisted tissue engagement through a minimally invasive incision|
|US20040138533 *||Dec 24, 2003||Jul 15, 2004||Spence Paul A.||Device to permit offpump beating heart coronary bypass surgery|
|US20040167549 *||Feb 18, 2004||Aug 26, 2004||Eric Boone||Method and apparatus for temporarily immobilizing a local area of tissue|
|US20040186356 *||Aug 5, 2002||Sep 23, 2004||O'malley Michael T.||Surgical retractor and tissue stabilization device|
|US20040225195 *||Jun 8, 2004||Nov 11, 2004||Spence Paul A.||Device to permit offpump beating heart coronary bypass surgery|
|US20040230099 *||Oct 14, 2003||Nov 18, 2004||Taylor Charles S.|
|US20050010197 *||Jul 8, 2003||Jan 13, 2005||Liming Lau||Organ manipulator apparatus|
|US20050033270 *||Jun 8, 2004||Feb 10, 2005||Intuitive Surgical, Inc.||Stabilizer for robotic beating-heart surgery|
|US20050148822 *||Dec 30, 2003||Jul 7, 2005||Willis Geoffrey H.||Organ manipulator and positioner and methods of using the same|
|US20050148824 *||Dec 30, 2003||Jul 7, 2005||Morejohn Dwight P.||Transabdominal surgery system|
|US20050148825 *||Feb 23, 2005||Jul 7, 2005||Spence Paul A.||Device to permit offpump beating heart coronary bypass surgery|
|US20050171404 *||Jan 7, 2005||Aug 4, 2005||Mische Hans A.||Surgical retractor having suture control features|
|US20070055108 *||Feb 1, 2006||Mar 8, 2007||Taylor Charles S|
|US20070123747 *||Jan 26, 2007||May 31, 2007||Eric Boone||Method and apparatus for temporarily immobilizing a local area of tissue|
|US20070156027 *||Dec 22, 2006||Jul 5, 2007||Hu Lawrence W||Surgical retractor platform blade apparatus|
|US20090082620 *||Dec 8, 2008||Mar 26, 2009||Medtronic, Inc.||Methods and Apparatus Providing Suction-Assisted Tissue Engagement Through a Minimally Invasive Incision|
|US20090099411 *||Dec 10, 2008||Apr 16, 2009||Spence Paul A||Device to permit offpump beating heart coronary bypass surgery|
|US20090099412 *||Dec 16, 2008||Apr 16, 2009||Spence Paul A||Device to Permit Offpump Beating Heart Coronary Bypass Surgery|
|US20090099576 *||Jul 16, 2008||Apr 16, 2009||Intuitive Surgical, Inc.||Minimally invasive surgical training using robotics and telecollaboration|
|US20090137865 *||Feb 5, 2009||May 28, 2009||Green Ii Harry Leonard||Tissue Stabilizer and Methods of Use|
|US20120143008 *||Jun 7, 2012||Rebecca Ann Wilkins||Expandable Surgical Access Port|
|US20150126816 *||Jan 14, 2015||May 7, 2015||Covidien Lp||Thoracic access assembly|
|WO2002056773A2 *||Jan 17, 2002||Jul 25, 2002||Genzyme Corp||Stabilizing device for performing surgical procedures on cardiac tissue|
|WO2003037190A1||Oct 9, 2002||May 8, 2003||Genzyme Corp||Segmented arm for holding a stabilizing tissue device|
|WO2003084408A1||Mar 5, 2003||Oct 16, 2003||Genzyme Corp||Cooled stabilizer for surgical procedures|
|U.S. Classification||600/213, 600/210, 600/235|
|International Classification||A61B17/12, A61B17/02, A61B17/11, A61B17/00|
|Cooperative Classification||A61B2017/00243, A61B2017/1107, A61B17/02, A61B17/11, A61B17/12, A61B2017/0243|
|Sep 16, 1997||AS||Assignment|
Owner name: BETH ISRAEL DEACONESS MEDICAL CENTER, MASSACHUSETT
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:COHN, WILLIAM;REEL/FRAME:008712/0359
Effective date: 19970730
|Sep 5, 2003||FPAY||Fee payment|
Year of fee payment: 4
|Sep 24, 2003||REMI||Maintenance fee reminder mailed|
|Aug 16, 2007||FPAY||Fee payment|
Year of fee payment: 8
|Sep 7, 2011||FPAY||Fee payment|
Year of fee payment: 12