|Publication number||US6080416 A|
|Application number||US 09/376,142|
|Publication date||Jun 27, 2000|
|Filing date||Aug 17, 1999|
|Priority date||Jan 20, 1998|
|Also published as||CA2259781A1, CA2259781C, DE69910454D1, DE69910454T2, EP0930066A2, EP0930066A3, EP0930066B1, US5972358|
|Publication number||09376142, 376142, US 6080416 A, US 6080416A, US-A-6080416, US6080416 A, US6080416A|
|Inventors||Hanuman B. Jampani, Anthony W. Newman|
|Original Assignee||Ethicon, Inc.|
|Export Citation||BiBTeX, EndNote, RefMan|
|Patent Citations (47), Non-Patent Citations (3), Referenced by (8), Classifications (40), Legal Events (5)|
|External Links: USPTO, USPTO Assignment, Espacenet|
This is a Divsional of prior application Ser. No. 09/009,489, filed Jan. 20, 1998, U.S. Pat. No. 5,972,358.
This application is related to my U.S. patent applications, Ser. No. 09/009,596, entitled ANTI-MICROBIAL COMPOSITION; and Ser. No. 09/009,491, entitled ALCOHOL BASED ANTI-MICROBIAL COMPOSITIONS WITH COSMETIC APPEARANCE, all concurrently filed herewith and which are assigned to assignee of the present invention and incorporated by reference as if fully set forth herein.
The present invention relates to lotions, gels and creams which are less sticky, more particularly to lotions and creams that contain lactate and silicone waxes.
Topical skin care formulations or products are being developed to provide moisturization without any greasiness or tackiness to maintain the skin integrity. In recent years alcohol based formulations are gaining importance in not only professional sector but also within the consumer sector, as consumer seek to find compositions with antibacterial and moisturization properties. It is well known that alcohols, such as ethyl alcohol, iso-propyl alcohol and n-propyl alcohol are dehydrating in nature when applied on skin. To reduce the dehydrating properties of alcohols certain moisturizers, emollients agents are being added. Unfortunately such product development efforts, typically many components are considered to formulate which could cause or contribute to undesirable features in the end product like tackiness, greasiness and unpleasant feel. In order to overcome these undesired attributes some detackifying compounds are employed in the formulation.
One such class of compounds disclosed in the prior art are silicones. Similarly, long chain lactate molecules are also in use as tack reducing components in a multi component matrix systems such as emulsions, cleansing lotions, creams, aqueous and non-aqueous based gels and other topical formulations that are used by hospital professionals and consumers.
For example, U.S. Pat. No. 4,423,041 discloses a detackifying composition for use in emulsion-type personal care compositions comprising a mixture of a silicone fluid and silicone wax in a ratio of 9:1 to 1:3. Despite this and other disclosures there is an ongoing need for a effective detackifying system for creams and lotions.
The particular invention is a composition comprising polymeric silicones in combination with lactate molecules. The polymeric silicones employed in the present invention are stearoxy trimethyl silane and cyclomethicone. The lactates used in the present invention are cetyl lactate and long chain alkyl lactate. The weight ranges between the stearoxy trimethyl silane and cyclomethicone is from about 1:75 to about 1:40; and the weight ratio between the cetyl lactate and the C12 -C15, alkyl lactates is from about 1:2 to about 1:5. When the combination of two silicones are used in presence of moisturizers such as glycerin, water, lipids, waxes, essential oils, acrylic polymers, a reduction of tack in the end was noted. A method for reducing the tackiness of creams, gels lotions and the like are also provided.
The present invention contains from about 0.01 to about 0.50 of stearoxy trimethyl silane, preferably from about 0.02 to about 0.10 and most preferably about 0.025 weight percent. The level of cyclomethicone is from about 0.5 to about 2.5, preferably from about 0.75 to about 2.0 and most preferably from about 1.0 to about 1.5 weight percent. The level of cetyl lactate is from about 0.25 to about 2.5 weight percent, preferably from about 0.4 to about 2.0 and most preferably from about 0.5 to about 1.5 weight percent. The level of alkyl (C12 -C15) lactates employed in the present invention ranges from about 0.25 to about 2.5 weight percent, preferably from about 0.3 to about 2.0 and most preferably from about 0.4 to about 1.5 weight percent. The weight ratio of the stearoxy trimethyl silane to the cyclomethicone is preferably from 1:50 to about 1:60. The weight ratio of the cetyl lactate to the alkyl lactate is preferably from about 1:2 to about 1:4.
This present invention has wide applications in developing tack reducing compositions or product formulations which are dermatologically acceptable. These detackifying combinations allow the formulation of products which are topically applicable to provide good feel with protection from environment. Particularly these tack reducing compositions are important in complex formulations like water/oil and oil/water emulsions, mineral oil or petrolatum based creams, alcoholic gels, high glycerin containing topical skin care products.
The tack reducing composition of the present invention are in addition to other ingredients typically found in hand creams, gels and lotions. Such materials include but are not limited to thickeners, antimicrobial agents, solvents, fragrances, emollients, pH adjusters, viscosity modifiers, transdermal enhancers, surfactants, dyes, colors and the like.
In a particularly preferred embodiment the tack reducing compounds of the present invention are used in a substantially waterless antiseptic gel wherein alcohol such as ethyl alcohol, iso-propyl and n-propyl alcohols are used.
The alcohol level in these waterless antiseptic/antibacterial gels are typically from about 20 to about 55 weight percent. In these systems a preferred embodiment of the invention employs stearoxy trimethyl silane at about 0.025 weight percent; cyclomethicone at about 1.25 weight percent; cetyl lactate at about 0.5 weight percent; and C12 -C15, alkyl lactates at about 1.5 weight percent.
Stearoxy trimethyl silane is not completely soluble in high content alcohol systems or alcoholic mixtures, and in such instances the Silsoft® PEDM (phenylethyl dimethicone) an organosilicone liquid is a good media to disperse the softened wax, and make it compatible with the system. In the absence of such a solvent, the wax may appear on hands as flakes due to recrystallization of the wax on the hands or due to rapid evaporation of alcohol.
A preferred cyclomethicone is commercially available as Dow Corning® 245 fluid. Cyclomethicone is a silicone oil which consists of decamethyl cyclopenta siloxane. Also commercially available and useful in the present invention is Dow Corning® 580 wax, a mixture of stearoxy trimethyl silane and stearyl alcohol, a semicrystalline silicone wax. The ratio between these two silicones along with the lactates is critical in presence of synergistic alcohols such as ethyl alcohol, isopropyl alcohol and n- propyl alcohol and other ingredients like glycerin, water, acrylic acid based carbomers as well as other thickeners, volatile oils, terpenes and other fragrances, and lipids. The combination of alkyl lactates such as cetyl lactate (CERAPHYL®-28) and C12 -C15 alkyl lactate (CERAPHYL®-41) in presence of silicone fluid and silicone wax has shown an improved tack reduction. When the ratio of the composition are not employed in the desired ratios results in undesirable flaking and balling on the hands after application of the product. Balling is the process of forming small balls believed to be formed from the thickening agents and other ingredients of the formulation. Balling is believed to be the result of a lack of sufficient moisture in the formulation, causing the formulation to become unstable and the ingredients to be deposited in small balls in the hand.
Conversely, when the lactate molecules are employed in formulations containing above said tack inducing agents, tack was noted with the end products. It has been surprisingly discovered that the addition of lactates to the mixture of silicones in the specified ratios reduced the level of tackiness in the product. The addition of the lactates in the prescribed levels reduced the evaporation rate of the product, thereby also moisturizing the hands and imparting a smooth and supple feeling. This supple feeling imparted by the product is important to consumers, doctors and nurses, who will be using the product.
Without wishing to be bound by any theory the present invention is believed to be due to formation of a mixture that evaporates rapidly leaving a protective layer of silicones and lactate molecules as an effective barrier.
This barrier is believe to prevent rapid loss of skin moisture. This feature of any product has an added advantage in particular with hydroalcoholic gels which have inherent dehydrating properties. The tack reducing compositions will also allow the consumer of the product containing the invention to put on latex gloves much faster than otherwise and provides extra protection for hands in terms of maintaining skin temperature and antimicrobial protection obtained by alcohol or antimicrobial compositions.
The following compositions were used in the present invention:
CERAPHYL-28 is primarily cetyl lactate, a waxy solid available from ISP Van Dyk Inc.
CERAPHYL-41 is a mixture of C12 -C15 alcohol lactates, available from ISP Van Dyk Inc.
ULTREZ 10 a carbomer polymer useful as a thickener available from BF Goodrich.
The following examples are presented for the purpose of illustrating the present invention and is not intended to limit the invention to those examples presented below. Unless otherwise noted all weights are understood to be weight percent. In the following examples the short chain alcohols are listed by volume.
Several hydroalcoholic formulations were prepared using this combination as shown in the below examples (Table 1). It is also applicable to most of the topical formulations which would need tack free attribute in compositions such described in this invention.
Formulation 1 ethyl alcohol 60.5; ULTREZ 10 0.45; glycerin 0.5; cylomethicone (245) 1.25; Dow Corning 580 wax 0.025; SILSOFT PEDM 0.2; CERAPHYL-41 1.0; CERAPHYL-28 0.5; AMP -95; fragrance 0.12 and deionized water.
Formulation 2 same as Formulation 1 above plus Australian tree oil 2.0 and Phospholipid CDM 0.05.
Formulation 3 same as Formualtion 2 except that the ethyl alcohol was removed and replaced with ethyl alchol 40.5; iso-propyl alcohol 15; and n-propyl alcohol 5.
Formulation 4 same as Formulation 1 except that the ethyl alcohol was removed and replaced with ethyl alchol 40.5; iso-propyl alcohol 15; and n-propyl alcohol 5.
Formulation 1 was used as a control. This formulation was not tacky but did not contain other ingredients commonly used in creams, lotions and gels for moisturizing and providing soft supple hands.
Formulations 2, 3 and 4 were found to be non-tacky when used with alcohol mixtures, essential oils such as Austraian tea tree oil, and phospholipid. This example demonstrates that the tack reducing composition is effective in the presence of emollients, moisturizers and high-boiling solvents, such as iso-propyl alcohol and n-propyl alcohol, and when used at various concentrations.
|Cited Patent||Filing date||Publication date||Applicant||Title|
|US2798053 *||Sep 3, 1952||Jul 2, 1957||Goodrich Co B F||Carboxylic polymers|
|US3133865 *||May 22, 1961||May 19, 1964||American Home Prod||Waveset composition comprising an aqueous lotion of polyvinyl alcohol and a carboxy vinyl polymer|
|US3886277 *||May 10, 1973||May 27, 1975||Schwarzkopf Gmbh Hans||Methods of controlling dandruff using 5,7-dichloro-8-hydroxy quinoline|
|US4134412 *||Nov 18, 1976||Jan 16, 1979||Wella Aktiengesellschaft||Hair setting lotion containing a chitosan derivative|
|US4257907 *||May 21, 1979||Mar 24, 1981||Monsanto Company||Disinfectant cleaning compositions|
|US4268424 *||Oct 30, 1979||May 19, 1981||Lever Brothers Company||Detergent bars containing di-, hydroxy and/or amino-carboxylic acid moisturizers|
|US4303543 *||Jul 23, 1979||Dec 1, 1981||The Procter & Gamble Company||Method for cleansing and conditioning the skin|
|US4326997 *||Oct 8, 1980||Apr 27, 1982||Fritzsche Dodge & Olcott Inc.||Fragrance compositions of alicyclic ketone and alcohol derivatives|
|US4402881 *||Nov 12, 1980||Sep 6, 1983||International Minerals & Chem. Corp.||Method of making organophilic clays|
|US4426310 *||Mar 19, 1982||Jan 17, 1984||Colgate-Palmolive Company||Low-irritation shampoo|
|US4464293 *||Apr 12, 1982||Aug 7, 1984||Dobrin Robert J||Liquid cleaner-disinfectant composition for use in wiping down dental operatories|
|US4474807 *||Sep 29, 1982||Oct 2, 1984||Henkel Kommandigesellschaft Auf Aktien||2-(3-Iodo-2-propynyloxy)-ethyl carbamates, the preparation thereof, and their use as antimicrobial agents|
|US4690821 *||Mar 28, 1986||Sep 1, 1987||Creative Products Resource Associates, Ltd.||Towel for skin moisturizing and drying|
|US4804750 *||Dec 11, 1986||Feb 14, 1989||Ihara Chemical Industry Co., Ltd.||Production of water-soluble chitin-oligomers by partial hydrolysis of chitin|
|US4816451 *||Jun 29, 1987||Mar 28, 1989||Bayer Aktiengesellschaft||Antibacterial 1,8-bridged 4-quinolonecarboxylic acids|
|US4849455 *||Oct 21, 1986||Jul 18, 1989||Kruger Gmbh & Co. Kg||Glycerol containing virucidal compositions|
|US4923862 *||Dec 17, 1987||May 8, 1990||Daiichi Seiyaku Co., Ltd.||Topical preparation containing ofloxacin|
|US4956170 *||Jun 28, 1989||Sep 11, 1990||S. C. Johnson & Son, Inc.||Skin moisturizing/conditioning antimicrobial alcoholic gels|
|US4957908 *||Jan 8, 1990||Sep 18, 1990||Olin Corporation||Chitosan pyrithione as antimicrobial agent useful in personal care products|
|US4966754 *||Aug 8, 1988||Oct 30, 1990||Aveda Corporation||Preservation of cosmetic compositions|
|US5004598 *||May 31, 1989||Apr 2, 1991||The B. F. Goodrich Company||Stable and quick-breaking topical skin compositions|
|US5053407 *||Jun 20, 1986||Oct 1, 1991||Daiichi Pharmaceutical Co., Ltd.||Optically active pyridobenzoxazine derivatives and anti-microbial use|
|US5098717 *||Feb 19, 1991||Mar 24, 1992||Thames Pharmacal Co., Inc.||Method of treatment for pruritus|
|US5109019 *||Jul 6, 1989||Apr 28, 1992||Henkel Kommanditgesellschaft Auf Aktien||Fungicidal mixtures|
|US5164107 *||Apr 25, 1991||Nov 17, 1992||Becton, Dickinson And Company||Chlorhexidine composition useful in a surgical scrub|
|US5180061 *||Sep 9, 1991||Jan 19, 1993||Becton, Dickinson And Company||Stable iodophor in polyurethane foam|
|US5180749 *||Aug 22, 1989||Jan 19, 1993||Sterling Winthrop, Inc.||Antimicrobial composition|
|US5288486 *||Mar 29, 1991||Feb 22, 1994||Calgon Corporation||Alcohol-based antimicrobial compositions|
|US5298242 *||Jun 23, 1992||Mar 29, 1994||L'oreal||Polyfluoroalkylthiopoly(ethylimidazolium) compounds, preparation process and their use as biocidal agents|
|US5308890 *||Feb 26, 1993||May 3, 1994||Rohm And Haas Company||Emulsion polymer blend of a multi-stage latex and a non-film forming latex|
|US5326492 *||Nov 18, 1991||Jul 5, 1994||Medical Polymers, Inc.||Disinfectant mixture containing water soluble lubricating and cleaning agents and method|
|US5335373 *||Nov 29, 1991||Aug 9, 1994||Dresdner Jr Karl P||Protective medical gloves and methods for their use|
|US5336305 *||Jul 6, 1993||Aug 9, 1994||International Laboratory Technology Corp.||Flexible material having barrier properties|
|US5401741 *||Apr 12, 1993||Mar 28, 1995||Daiichi Pharmaceutical Co., Ltd.||Topical preparation for treating otopathy|
|US5403587 *||Apr 22, 1993||Apr 4, 1995||Eastman Kodak Company||Disinfectant and sanitizing compositions based on essential oils|
|US5403864 *||Apr 1, 1993||Apr 4, 1995||John A. Manfuso, Jr.||Rapidly-acting topical antimicrobial composition|
|US5416109 *||Jan 19, 1994||May 16, 1995||Betz Laboratories, Inc.||Method and composition for controlling the growth of microorganisms|
|US5420104 *||Jun 16, 1993||May 30, 1995||Firmenich S.A.||Perfumed composition|
|US5512199 *||Nov 2, 1993||Apr 30, 1996||Becton Dickinson And Company||Hand wipe solution|
|US5540853 *||Oct 20, 1994||Jul 30, 1996||The Procter & Gamble Company||Personal treatment compositions and/or cosmetic compositions containing enduring perfume|
|US5607681 *||Jan 30, 1991||Mar 4, 1997||The Boots Company Plc||Anti-microbial compositions|
|US5626837 *||Feb 15, 1996||May 6, 1997||Lion Corporation||Oral composition|
|US5661170 *||Jun 12, 1996||Aug 26, 1997||Woodward Laboratories, Inc.||Antimicrobial compositions and methods for using the same|
|US5665742 *||May 24, 1995||Sep 9, 1997||Kao Corporation||Bath medicine composition and its use in inhibiting the generation of body odor|
|AU600269A *||Title not available|
|GB2326167A *||Title not available|
|WO1994027436A1 *||May 20, 1994||Dec 8, 1994||Benedict T Decicco||Preservative systems with enhanced antimicrobial activity|
|1||Chemical Abstracts, Jones, M.N. et al., "The Use of Phospholipid Liposomes for Targeting to Oral and Skin-Associated Bacteria", vol. 122, No. 8, pp. 381-389, 1994.|
|2||*||Chemical Abstracts, Jones, M.N. et al., The Use of Phospholipid Liposomes for Targeting to Oral and Skin Associated Bacteria , vol. 122, No. 8, pp. 381 389, 1994.|
|3||*||Lee W. Bush, Leslee M. Benson, and John H. White, Pig Skin Test Subtrate for Evaluating Topical Antimicrobial Activity, Sep. 1986, Journal of Clinical Microbiology.|
|Citing Patent||Filing date||Publication date||Applicant||Title|
|US6593283||Feb 27, 2001||Jul 15, 2003||Ecolab Inc.||Antimicrobial composition|
|US6998369||Apr 14, 2003||Feb 14, 2006||Ecolab Inc.||Antimicrobial composition|
|US7576045||Jun 15, 2005||Aug 18, 2009||Botica Comercial Farmaceutica Ltda||Use of vinic alcohol in personal care products, cosmetics and perfumes|
|US8246906||Feb 9, 2009||Aug 21, 2012||Ecolab Usa Inc.||Antimicrobial composition|
|US20030228996 *||Apr 14, 2003||Dec 11, 2003||Hei Robert D.P.||Antimicrobial composition|
|US20050276775 *||Jun 15, 2005||Dec 15, 2005||Botica Comercial Farmaceutica Ltda.||Use of vinic alcohol in personal care products, cosmetics and perfumes|
|US20060160712 *||Dec 22, 2005||Jul 20, 2006||Hei Robert D||Antimicrobial composition|
|US20100166886 *||Mar 12, 2010||Jul 1, 2010||Wu Jeffrey M||Methods of treating the skin|
|U.S. Classification||424/401, 424/78.03, 424/70.12, 514/844, 514/937, 514/944, 424/484, 514/943|
|International Classification||C08L83/04, A61K8/891, A61P17/00, A61K8/37, A61K47/14, A61K8/30, A61K47/34, A61K8/55, A61K9/06, A61Q19/00, A61K31/00, A61K8/897, A61K8/89, A61K8/893, A61K8/58, A61Q17/00|
|Cooperative Classification||Y10S514/944, Y10S514/844, Y10S514/943, Y10S514/937, A61K8/37, A61Q17/005, A61K8/891, A61Q19/00, A61Q17/00, A61K8/893, A61K8/585|
|European Classification||A61Q19/00, A61K8/893, A61K8/37, A61K8/58C, A61K8/891|
|Aug 17, 1999||AS||Assignment|
Owner name: ETHICON, INC., NEW JERSEY
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:JAMPANI, HANUMAN B.;NEWMAN, ANTHONY W.;REEL/FRAME:010183/0886
Effective date: 19990413
|Apr 10, 2001||CC||Certificate of correction|
|Nov 24, 2003||FPAY||Fee payment|
Year of fee payment: 4
|Nov 26, 2007||FPAY||Fee payment|
Year of fee payment: 8
|Sep 21, 2011||FPAY||Fee payment|
Year of fee payment: 12