Search Images Maps Play YouTube News Gmail Drive More »
Sign in
Screen reader users: click this link for accessible mode. Accessible mode has the same essential features but works better with your reader.

Patents

  1. Advanced Patent Search
Publication numberUS6125846 A
Publication typeGrant
Application numberUS 08/857,925
Publication dateOct 3, 2000
Filing dateMay 16, 1997
Priority dateMay 16, 1997
Fee statusPaid
Also published asDE69830021D1, DE69830021T2, EP0879612A2, EP0879612A3, EP0879612B1, US6581592
Publication number08857925, 857925, US 6125846 A, US 6125846A, US-A-6125846, US6125846 A, US6125846A
InventorsDuncan P. L. Bathe, Frederick J. Montgomery
Original AssigneeDatex-Ohmeda, Inc.
Export CitationBiBTeX, EndNote, RefMan
External Links: USPTO, USPTO Assignment, Espacenet
Purge system for nitric oxide administration apparatus
US 6125846 A
Abstract
A nitric oxide delivery system is disclosed that delivers a pulsed volume of NO containing therapeutic gas to a patient upon each inhalation of the patient. The NO delivery system includes certain functions to provide protection against the inadvertent inclusion of NO2 in the therapeutic gas administered to the patient. One of the functions is to provide a purge upon start up of the delivery system apparatus that clears the regulator and conduits of any NO2 that may have formed during the prior idle period of the system. A detector determines the start-up and may automatically carry out the purge cycle or may cause a prompt that is visual or audible to remind the user to carry out the purge cycle manually. As a further function, when the NO apparatus is terminated with respect to a patient, the system can, again, sense the termination or cessation of the therapy and automatically shut off the supply of NO containing gas at the source or provide an audible or visual prompt to remind the user to shut off the supply of the NO containing gas manually.
Images(3)
Previous page
Next page
Claims(15)
We claim:
1. A method for purging a nitric oxide delivery system of an oxygen containing gas to avoid the production of nitrogen dioxide in the system, said method comprising the steps of:
placing the system in an active state in which the system is capable of delivering nitric oxide containing gas to a patient;
sensing the commencement of the active state to initiate a purging of a conduit through which the nitric oxide containing gas is delivered from a source to a patient, the purging being carried out by passing nitric oxide containing gas along the conduit for a predetermined period of time to remove oxygen containing gas from the delivery system;
sensing a physical parameter of purging gas passage in the conduit to verify occurrence of the purge; and
delivering nitric oxide containing gas to a patient when the purge has been completed.
2. A method of purging a nitric oxide delivery system as defined in claim 1 wherein said step of purging includes the step of opening a location on the conduit and passing the nitric oxide containing gas into and through the conduit to vent through the opening.
3. A method of purging a nitric oxide delivery system as defined in claim 1 wherein said step of sensing a parameter comprises sensing the pressure of gas in the conduit.
4. A method of purging a nitric oxide delivery system as defined in claim 1 wherein said step of sensing a parameter comprises sensing the flow of gas in the conduit.
5. A method for purging a nitric oxide delivery system of an oxygen containing gas to avoid the production of nitrogen dioxide in the system, said method comprising the steps of:
placing the system in an inactive state in which delivery of nitric oxide containing gas to a patient is not carried out;
sensing the inactive state of the system and thereafter sealing a source of nitric oxide containing gas to avoid production of nitrogen dioxide in the source from oxygen containing gases in the system; and
purging a conduit by which the nitric oxide containing gas is delivered from the source to a patient, the purging being carried out by passing nitric oxide containing gas along the conduit for a predetermined period of time to remove oxygen containing gas from the delivery system.
6. A method of purging a nitric oxide delivery system as defined in claim 5 further including the step of sensing a physical parameter of the purging gas passage in the conduit to verify occurrence of the purging and sealing of the source of nitric oxide containing gas.
7. A method for purging a nitric oxide delivery system of an oxygen containing gas to avoid the production of nitrogen dioxide in the system, said method comprising the steps of:
placing the system in an active state in which the system is capable of delivering nitric oxide containing gas to a patient;
sensing the commencement of the active state to initiate a purging of a conduit through which the nitric oxide containing gas is delivered from a source to a patient, the purging being carried out by passing nitric oxide containing gas along the conduit for a predetermined period of time to remove oxygen containing gas from the delivery system; and
delivering nitric oxide containing gas to a patient when the purge has been completed.
8. A method of purging a nitric oxide delivery system as defined in claim 7 wherein said step of purging includes the step of opening a location on the conduit and passing the nitric oxide containing gas into and through the conduit to vent through the opening.
9. A method for purging a nitric oxide delivery system of oxygen containing gas to avoid the production of nitrogen dioxide in the system, said method comprising the steps of:
placing the system in an active state in which the system is capable of delivering nitric oxide containing gas to a user;
sensing the commencement of the active state to provide a prompt to a user of the system calling for the initiating of a purging of the system;
sensing a physical parameter of gas passing in the conduit as a result of a user initiated purge to verify occurrence of the purge; and
delivering nitric oxide containing gas to a user when the purge has been completed.
10. A method of purging a nitric oxide delivery system as defined in claim 9 further defined as providing a further prompt to a user indicating that a purge has taken place.
11. A method of purging a nitric oxide delivery system as defined in claim 9 wherein said step of sensing a parameter comprises sensing the pressure of the nitric oxide containing gas in the conduit.
12. A method of purging a nitric oxide delivery system as defined in claim 9 wherein said step of sensing a parameter comprises sensing the flow of the nitric oxide containing gas in the conduit.
13. A method for purging a nitric oxide delivery system of an oxygen containing gas to avoid the production of nitrogen dioxide in the system, said method comprising the steps of:
placing the system in an inactive state in which delivery of nitric oxide containing gas to a user is not carried out;
sensing the inactive state of the system to provide a prompt to a user of the system calling for a user initiated sealing of a source of nitric oxide containing gas and a user initiated purging of a conduit by which the nitric oxide containing gas is delivered from the source to a user, the purging being carried out by passing nitric oxide containing gas along the conduit for a predetermined period of time to remove oxygen containing gas from the delivery system to avoid production of nitrogen dioxide in the source from oxygen containing gases in the system; and
sensing a physical parameter of the purging gas passage in the conduit to verify occurrence of the purging and sealing of the source of nitric oxide containing gas.
14. A method for purging a nitric oxide delivery system of oxygen containing gases to avoid the production of nitrogen dioxide in the system, said method comprising the steps of:
placing the system in an active state in which the system is capable of delivering nitric oxide containing gas to a user;
sensing the commencement of the active state to provide a prompt to a user calling for the initiation of a purging of the system; and
delivering nitric oxide containing gas to a user when the purge has been completed.
15. A method for purging a nitric oxide delivery system of an oxygen containing gas to avoid the production of nitrogen dioxide in the system, said method comprising the steps of:
placing the system in an inactive state in which delivery of nitric oxide containing gas to a user is not carried out; and
sensing the inactive state of the system to provide a prompt to a user calling for a user initiated sealing of a source of nitric oxide containing gas and a user initiated purging of a conduit by which the nitric oxide containing gas is delivered from the source to a patient, the purging being carried out by passing nitric oxide containing gas along the conduit for a predetermined period of time to remove oxygen containing gas from the delivery system to avoid production of nitrogen dioxide in the source from oxygen containing gases in the system; and
delivering nitric oxide containing gas to a user when the purge has been completed.
Description
BACKGROUND

This invention relates to the administration of a therapeutic gas such as nitric oxide (NO) to patients for therapeutic effect. In particular, it relates to a system wherein a controlled, predetermined dose of NO is provided to the patient with each inhalation by the patient and to the use of various functions utilized by that system to control and/or eliminate nitrogen dioxide (NO2) from the system for safety reasons.

The function of the administration of NO has been fairly widely published and typical articles appeared in The Lancet, Vol. 340, October 1992 at pages 818-820 entitled "Inhaled Nitric Oxide in Persistent Pulmonary Hypertension of the Newborn" and "Low-dose Inhalational Nitric Oxide in Persistent Pulmonary Hypertension of the Newborn" and in Anesthesiology, Vol. 78, pgs. 413-416 (1993), entitled "Inhaled NO-the past, the present and the future".

The actual administration of NO is generally carried out by its introduction into the patient as a gas and commercially available supplies are provided in cylinders under pressure and may be at pressures of about 2000 psi and consist of a predetermined mixture of NO in a carrier gas such as nitrogen. A pressure regulator is therefore used to reduce the pressure of the supply cylinder to working levels for introduction to a patient.

The concentration administered to a patient will vary according to the patient and the need for the therapy but will generally include concentrations at or lower than 150 ppm. There is, of course, a need for that concentration to be precisely metered to the patient since an excess of NO can be harmful to the patient.

One current known method and apparatus for the administration of NO to patients is described in U.S. Pat. No. 5,558,083 where a system is provided that can be added to any ventilator and which will meter in the desired concentration of NO into the gas supplied from that ventilator.

Various other delivery devices have also been used that respond to the patient attempting to inhale to deliver a pulsed dose of NO to the patient and such pulsing devices have also been shown to have therapeutic effect on the patient, for example, as described in Higenbottam PCT patent application WO 95/10315 and the publication of Channick et al "Pulsed delivery of inhaled nitric oxide to patients with primary pulmonary hypertension", Chest/109/June 1996. In such pulsatile dosing devices, a pulse of NO is administered to the patient as the patient inhales spontaneously.

The inhalation pulsing type devices are typically shown and described in Durkan, U.S. Pat. No. 4,462,398. Another such apparatus is described in pending U.S. Patent application entitled "Constant Volume NO Pulse Delivery Device", filed on May 16, 1997, U.S. patent application Ser. No. 08//57,924, which was abandoned in favor of U.S. patent application Ser. No. 09/084,710, filed May 26, 1998, and owned by the same assignee.

One difficulty with such devices that provide a supplemental therapeutic gas to the patient concerns the formation of NO2 from NO. NO2 is a toxic compound and its presence is, therefore, undesirable in any appreciable concentration in the gas administered to the patient. Such toxic effects are present at concentrations of about 5 ppm and therefore even minute quantities of NO2 cannot be tolerated.

In the pulse dose devices that administer NO as a supplemental therapeutic gas to the patient, there is likely to be no monitor to sense the presence of NO2 and therefore it is important to take preventative measures in the system itself to assure that the formation of NO2 does not occur, or when it does occur, to remove the NO2 from the system before the NO containing therapy gas is delivered to the patient.

The formation of NO2 results from the reaction of NO with O2 and therefore there is ample opportunity in the administration of NO to a patient for NO2 to be formed. One possibility is when the administration device is connected to the NO therapy gas source, air can be trapped in the cylinder valve and regulator fittings when the connection is made and because the NO in the cylinder is typically only a few hundred parts per million even small volumes of air can provide enough oxygen to cause significant proportions of the NO to react and form NO2. Another possibility is that air can be trapped in passages of the regulator and regulator pressure gauge and which are not in the main flow passages. The main passages are cleared of air during use by the flow of NO therapy gas from the cylinder, however, when the device is turned off for any length of time the O2 in the air can diffuse out of these passages and can react with NO in the regulator and, if the cylinder valve is left open, the O2 can diffuse into the cylinder and react with the NO in the cylinder. The reaction of NO and O2 to form NO2 is a time related reaction, that is, the more time that the NO is in association with the O2, the more NO2 is formed, therefore it is important to provide prevention measures wherever there is any time period where the NO and O2 can be in contact with each other and provide means for removing the NO2 from the system.

Two of the rather critical periods where sufficient time can elapse and where NO and O2 may intermix and where the formation of NO2 may therefore occur are during start-up where NO may have been left in the system in contact with O2 from the prior use of the delivery system and also after a new cylinder has been attached to the delivery device and introduced new quantities of O2 (in air) into the delivery device. Another critical period is the termination of the administration of NO to a patient and the delivery system shut off. At that latter time, unless the cylinder valve controlling the supply of NO containing therapy gas is turned to the off position to isolate the NO supply from the NO delivery system, there is the possibility that any O2 remaining in the conduits of the regulator during the shut down period may migrate back into the cylinder of NO containing therapeutic gas and contaminate that cylinder of gas.

SUMMARY OF THE INVENTION

In accordance with the present invention, there is provided a nitric oxide delivery system where a volume of NO is administered to the patient and where certain safety steps are carried out to eliminate NO2 from the system to prevent the inadvertent administration of a toxic concentration of NO2 to the patient.

Therefore, as an aspect of the present invention, at the start up of the system, as indicated, there may be NO2 that formed in the various conduits during the time period when the delivery system was idle. At this point, therefore, the system may, upon the initiation of start-up, provide a visual or audible prompt to the user to carry out the purge manually or, in the alternative, there may be an automatic purge at the initiation of that start-up. In either case, the purge rids the system of any NO2 that may have formed during the time period the system was not in use.

As a further aspect of the present invention, the delivery system detects when the delivery of NO to the patient has been discontinued by the user and the system then either senses the discontinuance of the NO administration and provides a visual and/or audible prompt to the user so that the user can manually shut off the cylinder valve or, alternatively, automatically shuts off the cylinder valve to prevent O2 from migrating back into the cylinder thereby isolating the NO supply from the various conduits and regulator of the NO delivery system. Completion of this step can be confirmed by the system by checking that the flow or pressure in the system goes to zero when a purge is performed after the cylinder valve is turned off. If the valve has not been turned off the pressure or flow during a purge will remain at previous levels and the system can continue the prompt to the user that the cylinder valve needs to be shut off.

BRIEF DESCRIPTION OF THE DRAWINGS

FIG. 1 is a schematic view of a NO delivery system constructed in accordance with the present invention where the user is prompted to perform the purge task;

FIG. 2 is a logic diagram for a purge scheme using the NO delivery system shown in FIG. 1; and

FIG. 3 is a schematic view of an alternative scheme where a purge valve is automatically actuated.

DETAILED DESCRIPTION OF THE INVENTION

Turning now to FIG. 1, there is shown a schematic view of a pulsed dosing nitric oxide (NO) delivery system constructed in accordance with the present invention. A gas cylinder 10 is provided containing the therapeutic amount of nitric oxide. Preferable that NO gas is mixed with a balance or carrier gas such as nitrogen and the concentration may be in the order of 100 ppm. The NO in nitrogen gas is available commercially in cylinders at pressures of approximately 2000 psig.

Atop the gas cylinder 10 is a cylinder valve 12 and which controls the supply of NO containing therapy gas to the overall NO delivery system. As will be explained, the cylinder valve 12 may be of the manually operated type or may be controlled by a remote signal, such as by an electrical signal operating a solenoid valve. A pressure regulator 14 is located just downstream of the cylinder valve 12 and reduces the cylinder pressure down to a working pressure for use with the present system and that pressure may be in the order of about 50 psig. The pressure regulator 14 is connected to the cylinder 10 by a connector 13. A pressure gauge 16 is generally provided on the pressure regulator 12 in order to keep track of the pressure within the gas cylinder 10.

A conduit 18 carries the NO containing therapy gas from the pressure regulator 14 through to a patient 20 where the NO containing therapy gas is administered to the patient by means such as a patient utilization device 22, an example of which is a nasal cannula (not shown). It is sufficient to note that the patient utilization device 22 has an opening that communicates the NO containing therapy gas to the patient for inhalation thereof.

A control valve 30 controls the flow of NO containing therapy gas from the gas cylinder 10 to the patient 20 and is a solenoid controlled valve operated by a signal from a controller 28 which may be a central processing unit (CPU), logic circuit or analog circuit. Again, for safety, the control valve 30 is preferably normally closed and is moved to its open position when a signal energizes the valve by the controller 28. The control valve 30 is operated by the controller 28 in accordance with timed or other means of sending pulses of NO containing therapy gas to the patient and the particular algorithm of control is not a part of the present invention.

A user input device 32 allows the user to turn the NO delivery system to the on or the off condition. The user input device 32, at the same time, signals the appropriate condition to the controller 28. Also as a part of the system, there may be an audio alarm 34 and/or a visual display 36 to alert the user to certain conditions of the NO delivery system.

A user purge input device 38 allows the user to initiate the purge cycle. The user purge input device 38, at the same time, signals the appropriate condition to the controller 28.

Sensor 40 is provided to act as a monitor of certain parameters in the NO delivery system and the sensor 40, as will become apparent, may be a flow sensor, a pressure sensor or the like and which may be connected to the conduit 18 to sense that parameter at a location 42 between the gas cylinder 10 and the pressure regulator 14, at a location 44 between the pressure regulator 14 and the control valve 30, or at a location 46 between the control valve 30 and the patient utilization device 22. As shown, the preferred location is at the location 46 and that sensor communication is shown as a solid line, the other locations 42 and 44 are indicated as dashed lines.

Turning now to FIG. 2, there is shown a flow chart, taken along with FIG. 1, and which describes the overall operation of the NO delivery system. As noted, upon start-up of the system, the gas cylinder 10 containing the NO therapy gas in a predetermined concentration is opened and the NO containing therapy gas enters the pressure regulator 14 and the conduit 18. The user initiates the NO delivery system by the user input device 32 being set to the on position, and which "on" signal is communicated to the controller 28.

At this point, since the NO delivery system is being initiated, there is a likelihood that some NO2 may have formed in the conduit 18 or other parts of the delivery system since there may have been a considerable passage of time from the last use of the NO delivery system to allow the reacting of any remaining NO and O2 to have occurred or a new therapy gas cylinder 10 could have been connected to the delivery system allowing air to enter the system at the connector 13. According, the system must be initially purged to assure that no NO2 is present in any of the various components.

Upon the turning "on" of the device at 60, the controller 28 activates a purge prompt at 62 to inform the user to purge the system by audio alarm 34 and/or the visual display 36.

Activation of the purge at 64 by the user purge input device 38 opens the control valve 30 for a predetermined time at 66. During that time period the controller 28 determines if sufficient pressure, or flow, or the like, was present at 68 from the signal from sensor 40. As noted, the sensor 40 may be detecting various parameters of the gas in conduit 18, preferably flow or pressure.

If not, at 70 the controller 28 alerts the user that a purge was not successful by audible alarm 34 and/or the visual display 36.

If the sensor 40 detected sufficient pressure, or flow, or the like, at function 68 the controller 28 informs the user that a purge was performed successfully at 72 by the audible alarm 34 and/or the visual display 36.

Taking, now, the "shut down" cycle, upon the turning "off" of the device at 80, the controller 28 activates a purge prompt at 82 to inform the user to purge the NO delivery system by the audio alarm 34 and/or the visual display 36.

Activation of the purge at 84 by the user purge input device 38 opens the control valve 30 for a predetermined time at 86. During that time period the controller 28 determines if the pressure, or flow, or the like, from the signal from sensor 40, has decayed at 88 indicating that the cylinder valve 12 has been closed. The controller 28 then informs the user that a purge was performed successfully at 90 by the audible alarm 34 and/or the visual display 36.

If the sensor 40 detects that the pressure, or flow, or the like, has not decayed and therefore indicating that the cylinder valve 12 has not been closed, then the controller 28 alerts the user that a purge was not successful at 92, by the audible alarm 34 and/or the visual display 36.

Turning now to FIG. 3, again taken in connection with FIG. 2, there is shown a schematic view of an alternate to the manual purge of FIG. 1. Teed off from the conduit 18 at location 102 is a purge line 110 and a purge valve 100. As can be seen, the purge valve 100 is normally in the non-energized position blocking the flow of gas therethrough and is activated by controller 28 to open the purge valve 100 to clear certain portions of the conduit 18 as well as pressure regulator 14 of gas. The location of the purge valve 100 could also be at locations 104 and 106. As shown, the preferred location is at the location 102 and that is shown as a solid line, the other locations 104 and 106 are indicated as dashed lines.

Again the logic as shown in FIG. 2 can apply except that the turning on of the purge prompt at 62 and the manual activation of the purge at 64 are made automatic by appropriate signals from the controller 28.

Similarly, during shut down, the logic steps at 82 and 84 are automated by the controller 28 by providing the appropriate signals.

In either event, upon the completion of the turn "on" purge cycle, the controller 28 will assume the control of the control valve 30 to carry out its normal function of opening and closing the control valve 30 to provide NO containing therapy gas to the patient 20.

Accordingly, by a mandatory purge carried out automatically or by prompt to the user, at the initiation of the use of the NO delivery system and a mandatory or user prompted bleed purge at the cessation of the NO delivery system along with a verification that the NO supply has been isolated from the delivery system, the NO2 is effectively controlled and the possibility of NO2 being inadvertently introduced to the patient during the NO therapy is greatly minimized.

Numerous further variations and combinations of the features discussed above can be utilized without departing from the spirit of the invention as defined by the claims below. Accordingly, the foregoing description of the preferred embodiment should be taken by way of illustration rather than by way of limitation of the invention as claimed.

Patent Citations
Cited PatentFiling datePublication dateApplicantTitle
US4345612 *Jun 9, 1980Aug 24, 1982Citizen Watch Company LimitedAnesthetic gas control apparatus
US4461293 *Dec 3, 1982Jul 24, 1984Kircaldie, Randall, And McnabRespirating gas supply method and apparatus therefor
US4462398 *Dec 3, 1982Jul 31, 1984Kircaldie, Randal and McNab, TrusteeRespirating gas supply method and apparatus therefor
US4506666 *Dec 3, 1982Mar 26, 1985Kircaldie, Randall And McnabMethod and apparatus for rectifying obstructive apnea
US4519387 *Jun 22, 1984May 28, 1985Kircaldie, Randall And Mcnab, TrusteeRespirating gas supply method and apparatus therefor
US4570631 *Mar 25, 1985Feb 18, 1986Kircaldie, Randall And Mcnab (As Trustee)Respirating gas supply method and apparatus therefor
US4611590 *Nov 28, 1984Sep 16, 1986Dragerwerk AktiengesellschaftArrangement for adding liquid anesthetic to the respiratory gas supplied to a patient
US4612928 *Aug 28, 1984Sep 23, 1986Tiep Brian LMethod and apparatus for supplying a gas to a body
US4677975 *Oct 16, 1985Jul 7, 1987The University Of AucklandMethod of dispensing and/or a dispenser
US4685456 *Dec 2, 1985Aug 11, 1987Mary SmartSelf-retracting oxygen tubing
US4686975 *May 3, 1985Aug 18, 1987Applied Membrane Technology, Inc.Electronic respirable gas delivery device
US4705034 *Oct 2, 1985Nov 10, 1987Perkins Warren EMethod and means for dispensing respirating gases by effecting a known displacement
US4706664 *Apr 11, 1986Nov 17, 1987Puritan-Bennett CorporationInspiration oxygen saver
US4873971 *Oct 26, 1987Oct 17, 1989Perkins Warren EMethod and means for dispensing respirating gases by effecting a known displacement
US4932402 *Oct 16, 1987Jun 12, 1990Puritan-Bennett CorporationPulse translation apparatus
US4991576 *Oct 11, 1988Feb 12, 1991Henkin Melvyn LaneAnesthesia rebreathing system
US5005570 *Oct 3, 1989Apr 9, 1991Perkins Warren EMethod and means for dispensing respirating gases by effecting a known displacement
US5038771 *Jan 25, 1990Aug 13, 1991Dietz Henry GMethod and apparatus for respiratory therapy using intermittent flow having automatic adjustment of a dose of therapeutic gas to the rate of breathing
US5099836 *Jan 17, 1990Mar 31, 1992Hudson Respiratory Care Inc.Intermittent oxygen delivery system and cannula
US5099837 *Sep 28, 1990Mar 31, 1992Russel Sr Larry LInhalation-based control of medical gas
US5134886 *Apr 16, 1991Aug 4, 1992Ball Kenneth HCapacitive pressure transducer for use in respirator apparatus
US5165398 *Sep 24, 1991Nov 24, 1992Bird F MVentilator and oscillator for use therewith and method
US5241955 *Jan 7, 1991Sep 7, 1993Neotronics Medical LimitedBreathing apparatus
US5370112 *Jul 1, 1993Dec 6, 1994Devilbiss Health Care, Inc.Method and means for powering portable oxygen supply systems
US5558083 *Nov 22, 1993Sep 24, 1996Ohmeda Inc.Nitric oxide delivery system
US5560353 *Nov 29, 1994Oct 1, 1996TaemaEquipment and process for supplying doses of at least one gas to the respiratory tracts of a user
US5678537 *Mar 21, 1996Oct 21, 1997Ohmeda Inc.Oxygen flush for anesthesia systems
EP0589751A1 *Sep 13, 1993Mar 30, 1994L'air Liquide, Societe Anonyme Pour L'etude Et L'exploitation Des Procedes Georges ClaudeInstallation and procedure to deliver a gas mixture into the airways of a customer
WO1992010228A1 *Dec 5, 1991Jun 6, 1992Gen Hospital CorpDevices for treating pulmonary vasoconstriction and asthma
WO1994027664A1 *Jun 2, 1994Dec 8, 1994Niall KeaneyInhalation therapy
WO1995010315A1 *Oct 11, 1994Apr 20, 1995Timothy William HigenbottamNitric oxide treatment
Non-Patent Citations
Reference
1 *Channick et al. Chest, 109 Jun. 1996, pp. 1545 1549.
2Channick et al. Chest, 109 Jun. 1996, pp. 1545-1549.
3 *Pearl, Anesthesiology , V. 78, No. 3, Mar. 1993, pp. 413 416.
4Pearl, Anesthesiology, V. 78, No. 3, Mar. 1993, pp. 413-416.
5 *Roberts, et al The Lancet , vol. 340, Oct. 1992, pp. 818 820.
6Roberts, et al The Lancet, vol. 340, Oct. 1992, pp. 818-820.
Referenced by
Citing PatentFiling datePublication dateApplicantTitle
US6474333 *Jun 14, 2000Nov 5, 2002Instrumentarium Corp.Method for purging a medical fluid administration system
US6581592 *Jun 21, 2000Jun 24, 2003Datex-Ohmeda, Inc.Purge system for nitric oxide administration apparatus
US6581599 *Nov 24, 1999Jun 24, 2003Sensormedics CorporationMethod and apparatus for delivery of inhaled nitric oxide to spontaneous-breathing and mechanically-ventilated patients
US6786217 *Jan 21, 2003Sep 7, 2004Sensormedics CorporationMethod and apparatus of delivery of inhaled nitric oxide to spontaneous-breathing and mechanically-ventilated patients
US6831564 *Jun 11, 2002Dec 14, 2004Kendro Laboratory Products, Inc.Low supply tank pressure warning
US6837243 *Sep 30, 2003Jan 4, 2005Scott Technologies, Inc.Automatic transfer regulator for hose-line respirator
US6880556 *Jun 20, 2001Apr 19, 2005Teijin LimitedApparatus for supplying a therapeutic oxygen gas
US6901962 *Jan 3, 2002Jun 7, 2005Allied Healthcare Products, Inc.Surge prevention device
US6910504 *Jul 3, 2002Jun 28, 2005Allied Healthcare Products, Inc.Surge prevention device
US6920876 *Dec 10, 2002Jul 26, 2005Pulmonox Technologies CorporationDevice for administration of nitric oxide to horses spontaneously breathing
US6957661Mar 19, 2003Oct 25, 2005Harsco Technologies CorporationValve with pressurization rate reduction device
US7128080Aug 14, 2002Oct 31, 2006Allied Healthcare Products, Inc.Surge prevention device
US7174909May 3, 2005Feb 13, 2007Allied Healthcare Products, Inc.Surge prevention device
US7201166Aug 6, 2004Apr 10, 2007Gilbert BlaiseInjection system for delivery of a gaseous substance
US7455062Aug 10, 2005Nov 25, 2008The General Electric CompanyModular nitric oxide delivery device
US7516742Sep 23, 2005Apr 14, 2009Cardinal Health 207, Inc.Method and apparatus for delivery of inhaled nitric oxide to spontaneous-breathing and mechanically-ventilated patients with intermittent dosing
US7520866Jul 13, 2006Apr 21, 2009Sensormedics CorporationDevice and method for treatment of wounds with nitric oxide
US7530365Jan 11, 2007May 12, 2009Allied Healthcare Products, Inc.Surge prevention device
US7531133Jun 1, 2006May 12, 2009Pulmonox Technologies CorporationUse of nitric oxide gas in an extracorporeal circuitry to treat blood plasma
US7861717 *Dec 16, 2003Jan 4, 2011Ino Therapeutics GmbhControlled gas-supply system
US7892198Sep 17, 2004Feb 22, 2011Sensormedics CorporationDevice and method for treatment of surface infections with nitric oxide
US7955294Nov 10, 2006Jun 7, 2011Sensormedics CorporationIntermittent dosing of nitric oxide gas
US8079998Mar 2, 2007Dec 20, 2011Pulmonox Technologies CorporationMethods and devices for the delivery of therapeutic gases including nitric oxide
US8291904Jun 11, 2012Oct 23, 2012Ino Therapeutics LlcGas delivery device and system
US8397721Oct 28, 2011Mar 19, 2013Ino Therapeutics LlcSystem and method of administering a pharmaceutical gas to a patient
US8408206Jun 28, 2012Apr 2, 2013Ino Therapeutics LlcSystem and method of administering a pharmaceutical gas to a patient
US8517015Nov 2, 2011Aug 27, 2013Ino Therapeutics LlcSystem and method of administering a pharmaceutical gas to a patient
US8518457Nov 10, 2006Aug 27, 2013Pulmonox Technologies CorporationUse of inhaled gaseous nitric oxide as a mucolytic agent or expectorant
US8573209Jan 6, 2011Nov 5, 2013Ino Therapeutics LlcGas delivery device and system
US8573210Nov 15, 2012Nov 5, 2013Ino Therapeutics LlcNitric oxide delivery device
US8607792Jul 15, 2013Dec 17, 2013Ino Therapeutics LlcSystem and method of administering a pharmaceutical gas to a patient
US8616204Jul 15, 2013Dec 31, 2013Ino Therapeutics LlcSystem and method of administering a pharmaceutical gas to a patient
US8652064Sep 30, 2008Feb 18, 2014Covidien LpSampling circuit for measuring analytes
US8720440Jul 15, 2013May 13, 2014Ino Therapeutics LlcSystem and method of administering a pharmaceutical gas to a patient
US8757148May 27, 2009Jun 24, 2014Ino Therapeutics LlcDevices and methods for engaging indexed valve and pressurized canister assembly with collar and for linear actuation by plunger assembly into fluid communication with device for regulating drug delivery
US8776794Oct 29, 2013Jul 15, 2014Ino Therapeutics LlcNitric oxide delivery device
US8776795Oct 29, 2013Jul 15, 2014Ino Therapeutics LlcGas delivery device and system
EP2269614A1Aug 6, 2009Jan 5, 2011Ikaria Holdings, Inc.Methods of identifying a patient population eligible for treatment with nitric oxide via inhalation
EP2540304A1Aug 6, 2009Jan 2, 2013INO Therapeutics LLCMethods for reducing the risk or preventing the occurrence of an adverse event or serious adverse event associated with the inhalation of nitric oxide treatment
WO2011002606A1Jun 15, 2010Jan 6, 2011Ikaria Holdings, Inc.Methods of identifying a patient population eligible for treatment with nitric oxide via inhalation
Classifications
U.S. Classification128/202.22, 128/203.25, 128/203.14
International ClassificationA61M16/12, A61M16/10, A61M16/20
Cooperative ClassificationA61M2202/0275, A61M16/12, A61M16/202, A61M16/10
European ClassificationA61M16/10
Legal Events
DateCodeEventDescription
Mar 11, 2014ASAssignment
Owner name: CREDIT SUISSE AG, CAYMAN ISLANDS BRANCH, AS ADMINI
Free format text: PATENT SECURITY AGREEMENT (SECOND LIEN);ASSIGNOR:INO THERAPEUTICS LLC;REEL/FRAME:032426/0848
Effective date: 20140212
Free format text: PATENT SECURITY AGREEMENT (FIRST LIEN);ASSIGNOR:INO THERAPEUTICS LLC;REEL/FRAME:032426/0747
Feb 18, 2014ASAssignment
Free format text: RELEASE OF SECURITY INTEREST;ASSIGNOR:CREDIT SUISSE AG, CAYMAN ISLANDS BRANCH, AS COLLATERAL AGENT;REEL/FRAME:032274/0768
Owner name: INO THERAPEUTICS LLC, NEW JERSEY
Effective date: 20140212
Feb 14, 2014ASAssignment
Owner name: IKARIA INC., NEW JERSEY
Effective date: 20140212
Free format text: RELEASE OF SECURITY INTEREST;ASSIGNOR:CREDIT SUISSE AG, CAYMAN ISLANDS BRANCH, AS COLLATERAL AGENT;REEL/FRAME:032264/0517
Owner name: INO THERAPEUTICS LLC, NEW JERSEY
Jul 10, 2013ASAssignment
Effective date: 20130703
Owner name: CREDIT SUISSE AG, AS COLLATERAL AGENT, NEW YORK
Free format text: SECURITY AGREEMENT;ASSIGNORS:IKARIA, INC.;IKARIA ACQUISITION INC.;INO THERAPEUTICS LLC;REEL/FRAME:030764/0549
Mar 7, 2012FPAYFee payment
Year of fee payment: 12
Jul 31, 2011ASAssignment
Owner name: CREDIT SUISSE AG, CAYMAN ISLANDS BRANCH, AS COLLAT
Effective date: 20110622
Free format text: SECURITY AGREEMENT;ASSIGNORS:IKARIA, INC.;INO THERAPEUTICS LLC;REEL/FRAME:026676/0954
Jun 24, 2010ASAssignment
Effective date: 20100514
Free format text: RELEASE OF SECURITY INTERESTS;ASSIGNOR:CREDIT SUISSE AG, CAYMAN ISLANDS BRANCH, AS COLLATERAL AGENT;REEL/FRAME:24576/868
Owner name: INO THERAPEUTICS, LLC,NEW JERSEY
Owner name: IKARIA RESEARCH, INC. (F/K/A IKARIA, INC.),WASHING
Free format text: RELEASE OF SECURITY INTERESTS;ASSIGNOR:CREDIT SUISSE AG, CAYMAN ISLANDS BRANCH, AS COLLATERAL AGENT;REEL/FRAME:024576/0868
May 28, 2008FPAYFee payment
Year of fee payment: 8
May 28, 2008SULPSurcharge for late payment
Year of fee payment: 7
Apr 14, 2008REMIMaintenance fee reminder mailed
Apr 2, 2007ASAssignment
Owner name: CREDIT SUISSE, AS COLLATERAL AGENT, NEW YORK
Free format text: SECURITY AGREEMENT;ASSIGNORS:INO THERAPEUTICS LLC;IKARIA, INC.;REEL/FRAME:019094/0784
Effective date: 20070328
Feb 9, 2005ASAssignment
Owner name: INO THERAPEUTICS LLC, NEW JERSEY
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:DATEX-OHMEDA, INC.;REEL/FRAME:015687/0540
Effective date: 20041105
Owner name: INO THERAPEUTICS LLC 6 STATE ROUTE 173CLINTON, NEW
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:DATEX-OHMEDA, INC. /AR;REEL/FRAME:015687/0540
Apr 2, 2004FPAYFee payment
Year of fee payment: 4
May 30, 2000ASAssignment
Owner name: DATEX-OHMEDA, INC., WISCONSIN
Free format text: CHANGE OF NAME;ASSIGNOR:OHMEDA, INC.;REEL/FRAME:010841/0450
Effective date: 19981231
Owner name: DATEX-OHMEDA, INC. P.O. BOX 7550 MADISON WISCONSIN
Nov 3, 1997ASAssignment
Owner name: OHMEDA INC., NEW JERSEY
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:BATHE, DUNCAN P. L.;MONTGOMERY, FREDERICK J.;REEL/FRAME:008772/0098
Effective date: 19970707