|Publication number||US6601581 B1|
|Application number||US 09/704,099|
|Publication date||Aug 5, 2003|
|Filing date||Nov 1, 2000|
|Priority date||Nov 1, 2000|
|Also published as||WO2002055131A2, WO2002055131A3|
|Publication number||09704099, 704099, US 6601581 B1, US 6601581B1, US-B1-6601581, US6601581 B1, US6601581B1|
|Original Assignee||Advanced Medical Applications, Inc.|
|Export Citation||BiBTeX, EndNote, RefMan|
|Patent Citations (136), Non-Patent Citations (3), Referenced by (105), Classifications (11), Legal Events (10)|
|External Links: USPTO, USPTO Assignment, Espacenet|
The present invention relates to a drug delivery system. In particular the present invention relates to a pocket size or hand held ultrasonic-pulmonary drug delivery system.
In many medical applications it is necessary to make aerosols from liquids and powders. One of the therapeutic medical uses of ultrasound waves is in liquid aerosol mist production. Aerosol mist production makes use of a nebulizer or inhaler to produce an aerosol mist for creating a humid environment and delivering a drug to the lung.
Particularly for oral-pulmonary applications it is necessary to atomize medications, such as antibiotics, insulin, asthma drugs, and other drugs to make an aerosol that reaches the mouth, boucle, intestine and consequently the lungs.
Ultrasonic nebulizers operate by passing ultrasound waves of sufficient intensity through a liquid, the waves being directed at an air-liquid interface of the liquid from a point underneath or within the liquid. Liquid particles are ejected from the surface of the liquid into the surrounding air following the disintegration of capillary waves produced by the ultrasound. This technique can produce a very fine dense fog or mist. Aerosol mists produced by ultrasound are preferred because a smaller particle size of the aerosol can be obtained with the ultrasonic waves.
One of the major shortcomings of known ultrasonic inhalers and nebulizers is that there is no directed aerosol to the target. Therefore, an air stream is required to direct the aerosol to the target; however, this decreases the efficiency of ultrasound mist.
The device of the present invention comprises a means for creating a directed spray of liquid or powder particles produced by contact of the liquid or powder with a radiation surface of any ultrasound transducer such as, for example, a piezofilm or ultrasound tip. The ultrasonic waves cause the spray to project outwardly from the radiation surface of the transducer, and a particle spray is directed to the mouth.
Accordingly, the device of the present invention generates a directed particle spray, created by ultrasound waves, into a mouth and delivers a sharp dosage of a uniform up to 90% particle size drug.
Furthermore, the ultrasound waves used in the device energize the drug and cause penetration of the drug below the surface of the tissue.
Finally, the device of the present invention for drug delivery is particularly advantageous when sharp dosage drug delivery is desirable, such as, for example, with insulin for diabetic care. Piezoelectric oscillatory and liquid atomization system, is known with a bending oscillator or working plate for atomization of liquid. A disadvantage of these piezoelectric atomizers is that the particle sizes are not uniform and particle sizes of about 0.1 micron to several millimeters are obtained. The particles of larger diameter must be retained by means of a mechanical droplet separator.
A number of prior art references are available in the art, each of which references are directed to some specific discreet elements of the system which is described and claimed in the present invention, however, none of which is directed to the totality of the combination, or its use and function in the manner described and claimed herein:
Ultrasonic sprayers from Sonic and Materials, Inc., Misonix, Inc., Sono-Tek, Inc., Zevex International, Inc. U.S. Pat. Nos. 3,765,606, 4,659,014, 5,104,042, 4,930,700, 4,153,201, 4,655,393, 5,516,043, 5,835,678, 5,879,364 and 5,843,139, etc., operate by passing liquid through a central orifice of an ultrasound instrument tip which creates problems with dosage control, heating of the drug, non-uniform particles, and other related difficulties.
Ultrasonic inhalers and drug delivery systems from Medisonic USA, Inc., 3M, Siemens Gmb, The Procter Gamble Company, Sheffield Pharmaceuticals, Aradigm, Inc., U.S. Pat. Nos. 4,294,407, 5,347,998, 5,520,166, 5,960,792, 6,095,141, 6,102,298, 6,098,620, 6,026,808, and 6,106,547, operate by atomizing liquid using piezoceramic film and air/propellant.
U.S. Pat. No. 4,912,357 describes a MHz oscillator with a concave surface adapted to the defined (limited V≦) liquid quantity to be atomized.
In U.S. Pat. No. 5,950,619 a propellant is used along with ultrasound. Another disadvantage of this device is that the atomization surface is button shaped, which creates uniform particles, and the distance between valve and atomization surface is hardly achievable in industrial assemble process (0.1 to 0.5 mm).
U.S. Pat. Nos. 5,586,550, 5,758,637, 5,938,117, 6,014,970, and 6,085,740 are based in driving liquid through the hole made on a piezofilm's working area. Bending waves are used, which spray non-uniform liquid particles.
U.S. Pat. No. 5,261,601 describes an atomizer having a membrane covering a liquid chamber. U.S. Pat. No. 4,533,082 describes a liquid sprayer with multiple orifices on the vibrating element.
It is an object of the present invention to provide an improved device for oral pulmonary drug delivery.
It is also an object of the present invention to provide an improved device for oral pulmonary drug delivery using ultrasonic waves.
It is another object of the present invention to provide a device for the delivery of drugs ultrasonically with high efficiency.
It is yet another object of the present invention to provide a device for the delivery of drugs without the use of air or other propellants.
It is therefore an object of the present invention to provide a device for delivering drugs which affords highly precise dosage control.
It is a further object of the present invention to provide a method for the delivery of uniformed particles of a drug using ultrasonic waves.
These and other objects of the invention will become apparent from the following discussion below.
The present invention provides for a drug delivery system. More particularly the present invention provides for a pocket size or hand held ultrasonic oral—pulmonary liquid and powder drug delivery device.
In one embodiment the device of present invention is characterized in that it is able to produce a spray and deliver it to the oral/pulmonary tract, without use of air or other propellants and with such spray having greater than about 90% uniform particle size, with a high degree of dosage control.
The device of the invention comprises means for creating a directed spray of liquid or powder particles produced by contact of the liquid or powder with a radiation surface of ultrasound transducer such as, for example, a piezofilm/disk or ultrasound tip. The ultrasonic waves produced cause the spray to project outwardly from the radiation surface of the transducer. The particle spray is directed into the mouth for oral/pulmonary delivery.
According to the device of the present invention directed particle spray, created by ultrasound waves into a mouth delivers sharp dosage and uniform up to 90% particle size drug.
Furthermore, the ultrasonic waves used in the device, energize the drug and cause penetration of the drug below the surface of the tissue.
Finally, the device of the invention for drug delivery is particularly advantageous when sharp dosage drug delivery is desirable, such as in insulin therapy for diabetic care, and similar applications.
The construction and obvious advantages of the system provided for by the present invention will be more clearly understood from the following description of the various specific embodiments when read in conjunction with the accompanying drawings.
FIG. 1 is perspective view of the concept of an ultrasonic aerosol drug delivery device according to the present invention showing the principal elements as they relate to one another;
FIG. 2 is a lateral cross-sectional elevational view of one embodiment of the ultrasonic aerosol drug delivery device according to the invention with a piezofilm or piezodisc working element;
FIG. 3 is a lateral cross-sectional elevational view of another embodiment of the ultrasonic aerosol drug delivery device according to the invention, using an ultrasound tip with an enlarged distal end/radiation surface placed at an angle;
FIG. 4 is a lateral cross-sectional elevational view of another embodiment of the ultrasonic aerosol drug delivery device according to the invention, using an ultrasound tip with an enlarged distal end/radiation surface placed horizontally;
FIG. 5 is a lateral cross-sectional elevational view of another embodiment of the ultrasonic aerosol drug delivery device according to the invention, using an ultrasound tip with a cylindrical distal end/radiation surface placed at an angle;
FIG. 6 is a lateral cross-sectional elevational view of another embodiment of ultrasonic aerosol drug delivery device according to the invention, using an ultrasound tip with the cylindrical end/radiation surface, placed horizontally;
FIG. 7 is a lateral cross-sectional elevational view of another embodiment of the ultrasonic aerosol drug delivery device according to the invention, using an ultrasound tip with a truncated angled distal end/radiation surface, placed horizontally; and
FIG. 8 is a lateral cross-sectional elevational view of another embodiment of the ultrasonic aerosol drug delivery device according to the invention, using an alternative power supply as an AC adaptor.
The present invention is directed to a method and device for ultrasonic aerosol drug delivery, characterized by a means for first delivering a liquid or powder drug to a radiation surface of a piezofilm/disk or ultrasonic transducer tip such that the liquid is dropped to the radiation surface under gravity. For this purpose, and to easily produce a spray, the radiation surface of the piezofilm/disk or ultrasonic transducer must be placed at some angle with relation the horizontal. The actual radiation surface or geometric form of the ultrasound transducer tip may be one of many different shapes, such as, for example, cylindrical, oval, elliptical, square, rectangular, multi-angular, or another shape. Furthermore, the placement of the radiation surface at some angle allows one to get aerosol spray emanating from one point that is the touch point of the liquid with the radiation surface, which is a very important consideration and critical to obtaining uniform aerosol particle size. With the method and device of the present invention one is able to achieve substantial uniformity of particle size, to a degree of about 90% or greater.
The step of producing the aerosol spray preferentially includes operating the transducer in such a manner as to produce ultrasonic waves having a frequency of from about 18 kHz to about 10,000 MHz. It is within the scope of the invention that the frequency could be less than about 18 kHZ or greater than 10,000 MHz.
The frequency may be constant, modulated or pulsed. The wave form produced may be sinusoidal, rectangular, trapezoid or triangular.
Frequencies below 18 kHz can be used as well; however, lower frequencies are less desirable due the fact that this range of sonic, or sound, waves can be uncomfortable to the patient. A most preferred range of frequencies is from about 20 to 200 kHz. Frequencies of about 100 kHz are most preferred.
The device and method of the present invention can also include means for directing the spray into the mouth or at a target for from about 1 second to about 30 minutes, dependant upon the required dosage. The liquid or powder to be sprayed can include any drug, such as, for example, an antibiotic or antiseptic, and/or liquid which can be, for example, saline, water (distilled or regular), or oil.
The distance between the radiation surface of the transducer or piezofilm/disk and the liquid tube will. preferably be about the size of liquid drop diameter ≈0.5 mm and above. Distances of less than 0.5 mm (up to 50 micron) can be used as well; however, this may cause some assembly difficulties.
In one preferred embodiment the method and device of present invention provides aerosol drug delivery with no air stream, no propellant and no pressure.
FIG. 1 depicts a basic concept of the ultrasonic aerosol drug delivery method and device according to the invention. A liquid (drug) drop or flow 10 falls under gravity to a radiation surface 13 of piezofilm/disk 15 via dispenser tube 12. Drop 10 contacts surface 13 at point 14 and creates directed aerosol 16. Radiation surface 13 of piezofilm/disk 15 is placed at an angle θ with respect to the horizontal.
In FIG. 2, which depicts a cross-sectional view of one preferred embodiment of the aerosol drug delivery device according to the invention, housing 24 includes piezofilm/disk 15 and liquid reservoir 19, which is may or may not be disposable. Housing 24 is also provided with a liquid dispenser 17, an electronic circuit board 20, a battery or capacitor 22, and an on/off button 21. Button 21 activates electronic circuit board 20, which is electrically connected to piezofilm/disk and causes piezofilm/disk 15 to oscillate. Liquid 18 from reservoir 19 is dispensed and delivered to radiation surface 13 (with an amplitude of ultrasound waves greater than 5 microns) at contact point 14, creating aerosol 16 which is directed to a mouth/target (not shown). Nozzle 25, which directs aerosol 16 into a patient's mouth/target, may or may not be disposable.
FIG. 3 depicts a cross-sectional view of another embodiment of the aerosol drug delivery device according to the invention having an ultrasound transducer tip. The convenient location of surface 13 of a transducer tip 26 at an angle with the horizontal allows liquid or powder drop 10 delivered to the contact point 14 with gravity. The distance between distal end of tube 12 and contact point 14 or radiation surface 13 is less than or equal to the diameter of the liquid drop, and the aerosol drug delivery device will work in any position. If this distance between the distal end of tube 12 and contact point 14 on surface 13 is greater then a drop's diameter, then the device will only work vertically, which should not create a problem for the user.
FIG. 4 is a cross-sectional view of another preferred embodiment of the ultrasonic aerosol drug delivery device according to the invention with a transducer tip 26. As illustrated, in this case liquid drop 10 must be directed exactly to the corner of the radiation surface of ultrasound tip 26. After touching the corner, liquid drop 10 pulls to the radiation surface 13, spreads and is aerosolized and directed to the mouth/target.
With reference to FIGS. 5 and 6, which illustrate cross-sectional views of another preferred embodiment of the present invention, shown are a regular and cylindrical ultrasound transducer tip placed at an angle and horizontally, respectively.
With reference to FIG. 7, which illustrates a cross-sectional view of another embodiment according to the invention, shown is truncated ultrasound tip 26, which allows one to create a liquid or powder aerosol spray more easily.
With reference to FIG. 8, which illustrates a cross-sectional view of another preferred embodiment according to the invention, shown are an ultrasonic aerosol drug delivery device with an alternative power supply 23.
It will be further apparent to one skilled in this art that the improvements provided for in the present invention, while described with relation to certain specific physical embodiments also lend themselves to being applied in another physical arrangements not specifically provided for herein, which are nonetheless within the spirit and scope of the invention taught here.
|Cited Patent||Filing date||Publication date||Applicant||Title|
|US3275059||May 10, 1965||Sep 27, 1966||Little Inc A||Nozzle system and fuel oil burner incorporating it|
|US3392916||Nov 22, 1966||Jul 16, 1968||Carl Gunnar Daniel Engstrom||Ultrasonic atomizer|
|US3561444 *||May 22, 1968||Feb 9, 1971||Bio Logics Inc||Ultrasonic drug nebulizer|
|US3860173||Mar 27, 1974||Jan 14, 1975||Sata Naoyasu||Non-polluting combustion engine having ultrasonic fuel atomizer in place of carburetor|
|US4052004||Feb 18, 1976||Oct 4, 1977||Plessey Handel Und Investments A.G.||Vibratory atomizer|
|US4085893||Sep 3, 1976||Apr 25, 1978||Durley Iii Benton A||Ultrasonic humidifiers, atomizers and the like|
|US4153201||Nov 8, 1976||May 8, 1979||Sono-Tek Corporation||Transducer assembly, ultrasonic atomizer and fuel burner|
|US4251031||Jun 22, 1979||Feb 17, 1981||Plessey Handel Und Investments Ag||Vibratory atomizer|
|US4271705 *||Nov 26, 1979||Jun 9, 1981||Karl Deutsch Pruf-und Messgerate||Method and device for generating acoustic pulses|
|US4294407||Dec 17, 1979||Oct 13, 1981||Bosch-Siemens Hausgerate Gmbh||Atomizer for fluids, preferably an inhalation device|
|US4301093 *||Jul 25, 1980||Nov 17, 1981||Bosch Siemens Hausgerate Gmbh||Atomizer for liquid|
|US4301968||Apr 3, 1979||Nov 24, 1981||Sono-Tek Corporation||Transducer assembly, ultrasonic atomizer and fuel burner|
|US4309989||Aug 14, 1978||Jan 12, 1982||The Curators Of The University Of Missouri||Topical application of medication by ultrasound with coupling agent|
|US4319155 *||Dec 11, 1979||Mar 9, 1982||Omron Tateisi Electronics Co.||Nebulization control system for a piezoelectric ultrasonic nebulizer|
|US4334531 *||Jun 18, 1980||Jun 15, 1982||Bosch-Siemens Hausgerate Gmbh||Inhalator|
|US4352459||Dec 3, 1979||Oct 5, 1982||Sono-Tek Corporation||Ultrasonic liquid atomizer having an axially-extending liquid feed passage|
|US4428531||Aug 19, 1980||Jan 31, 1984||Eaton Corporation||Method of producing a fuel injector|
|US4466571||Jun 22, 1982||Aug 21, 1984||Muehlbauer Reinhard||High-pressure liquid injection system|
|US4530360||Nov 12, 1982||Jul 23, 1985||Duarte Luiz R||Method for healing bone fractures with ultrasound|
|US4541564||Jan 5, 1983||Sep 17, 1985||Sono-Tek Corporation||Ultrasonic liquid atomizer, particularly for high volume flow rates|
|US4582654 *||Sep 12, 1984||Apr 15, 1986||Varian Associates, Inc.||Nebulizer particularly adapted for analytical purposes|
|US4619400||Jun 13, 1984||Oct 28, 1986||Shell Oil Company||Self cleaning variable width annular slit atomizer|
|US4642581||Jun 21, 1985||Feb 10, 1987||Sono-Tek Corporation||Ultrasonic transducer drive circuit|
|US4655393||Feb 27, 1986||Apr 7, 1987||Sonotek Corporation||High volume ultrasonic liquid atomizer|
|US4659014||Sep 5, 1985||Apr 21, 1987||Delavan Corporation||Ultrasonic spray nozzle and method|
|US4679551||Feb 22, 1985||Jul 14, 1987||Tomtec, N.V.||Device for performing therapeutic treatments|
|US4726523||Dec 6, 1985||Feb 23, 1988||Toa Nenryo Kogyo Kabushiki Kaisha||Ultrasonic injection nozzle|
|US4726525||May 9, 1986||Feb 23, 1988||Toa Nenryo Kogyo Kabushiki Kaisha||Vibrating element for ultrasonic injection|
|US4733820||Dec 6, 1985||Mar 29, 1988||Toa Nenryo Kogyo Kabushiki Kaisha||Vibrating element for use on an ultrasonic injection nozzle|
|US4756478||Dec 6, 1985||Jul 12, 1988||Toa Nenryo Kogyo Kabushiki Kaisha||Vibrating element for use on an ultrasonic injection nozzle|
|US4783003||Mar 3, 1987||Nov 8, 1988||Toa Nenryo Kogyo Kabushiki Kaisha||Ultrasonic injecting method and injection nozzle|
|US4790479||Feb 8, 1988||Dec 13, 1988||Omron Tateisi Electronics Co.||Oscillating construction for an ultrasonic atomizer inhaler|
|US4793339 *||Feb 4, 1988||Dec 27, 1988||Omron Tateisi Electronics Co.||Ultrasonic atomizer and storage bottle and nozzle therefor|
|US4850534||Apr 19, 1988||Jul 25, 1989||Tdk Corporation||Ultrasonic wave nebulizer|
|US4877989 *||Jan 12, 1989||Oct 31, 1989||Siemens Aktiengesellschaft||Ultrasonic pocket atomizer|
|US4905671||Jan 11, 1988||Mar 6, 1990||Dornier Medizintechnik Gmbh||Inducement of bone growth by acoustic shock waves|
|US4930700||Oct 19, 1988||Jun 5, 1990||Atochem North America||Ultrasonic dispersion nozzle having internal shut-off mechanism with barrier fluid separation|
|US4941618||Jul 7, 1986||Jul 17, 1990||Leeman Labs Inc.||Nebulizer employing a fine mesh screen|
|US4961885||Nov 24, 1989||Oct 9, 1990||Elecsys Ltd.||Ultrasonic nebulizer|
|US5002059||Jul 26, 1989||Mar 26, 1991||Boston Scientific Corporation||Tip filled ultrasound catheter|
|US5040537||Nov 21, 1988||Aug 20, 1991||Hitachi, Ltd.||Method and apparatus for the measurement and medical treatment using an ultrasonic wave|
|US5063922||Oct 27, 1988||Nov 12, 1991||Etala-Hameen Keuhkovammayhdistys R.Y.||Ultrasonic atomizer|
|US5076266||Apr 19, 1989||Dec 31, 1991||Azerbaidzhansky Politekhnichesky Institut Imeni Ch. Ildryma||Device for ultrasonic atomizing of liquid medium|
|US5104042||Mar 29, 1990||Apr 14, 1992||Atochem North America, Inc.||Ultrasonic dispersion nozzle with internal shut-off mechanism having barrier-fluid separation means incorporated therewith|
|US5115805||Feb 23, 1990||May 26, 1992||Cygnus Therapeutic Systems||Ultrasound-enhanced delivery of materials into and through the skin|
|US5134993 *||Dec 11, 1989||Aug 4, 1992||Siemens Aktiengesellschaft||Inhalator device, in particular a pocket inhalator|
|US5163433||Oct 21, 1991||Nov 17, 1992||Olympus Optical Co., Ltd.||Ultrasound type treatment apparatus|
|US5172692||Dec 5, 1990||Dec 22, 1992||Kulow Howard H||Method for inflammatory response management|
|US5186162||Dec 17, 1990||Feb 16, 1993||Interpore Orthopaedics, Inc.||Ultrasonic transducer device for treatment of living tissue and/or cells|
|US5197946||Jul 10, 1991||Mar 30, 1993||Shunro Tachibana||Injection instrument with ultrasonic oscillating element|
|US5211160||Mar 19, 1991||May 18, 1993||Interpore Orthopaedics, Inc.||Ultrasonic orthopedic treatment head and body-mounting means therefor|
|US5231975||Mar 2, 1992||Aug 3, 1993||Cygnus Therapeutic Systems||Ultrasound-enhanced delivery of materials into and through the skin|
|US5269291||Dec 10, 1990||Dec 14, 1993||Coraje, Inc.||Miniature ultrasonic transducer for plaque ablation|
|US5315998||Mar 20, 1992||May 31, 1994||Katsuro Tachibana||Booster for therapy of diseases with ultrasound and pharmaceutical liquid composition containing the same|
|US5316000||Jan 21, 1992||May 31, 1994||Technomed International (Societe Anonyme)||Use of at least one composite piezoelectric transducer in the manufacture of an ultrasonic therapy apparatus for applying therapy, in a body zone, in particular to concretions, to tissue, or to bones, of a living being and method of ultrasonic therapy|
|US5318014||Sep 14, 1992||Jun 7, 1994||Coraje, Inc.||Ultrasonic ablation/dissolution transducer|
|US5323769||Aug 2, 1993||Jun 28, 1994||Cygnus Therapeutic Systems||Ultrasound-enhanced delivery of materials into and through the skin|
|US5324255||Jul 10, 1992||Jun 28, 1994||Baxter International Inc.||Angioplasty and ablative devices having onboard ultrasound components and devices and methods for utilizing ultrasound to treat or prevent vasopasm|
|US5345940||Nov 6, 1992||Sep 13, 1994||Mayo Foundation For Medical Education And Research||Transvascular ultrasound hemodynamic and interventional catheter and method|
|US5347998||Jul 8, 1991||Sep 20, 1994||Minnesota Mining And Manufacturing Company||Breath actuated inhaler having an electromechanical priming mechanism|
|US5362309||May 10, 1993||Nov 8, 1994||Coraje, Inc.||Apparatus and method for enhanced intravascular phonophoresis including dissolution of intravascular blockage and concomitant inhibition of restenosis|
|US5374266||Nov 25, 1992||Dec 20, 1994||Kabushiki Kaisha Morita Seisakusho||Medical laser treatment device|
|US5380411||Dec 2, 1988||Jan 10, 1995||Schering Aktiengesellschaft||Ultrasound or shock wave work process and preparation for carrying out same|
|US5393296||Dec 9, 1992||Feb 28, 1995||Siemens Aktiengesellschaft||Method for the medical treatment of pathologic bone|
|US5437606||Mar 28, 1994||Aug 1, 1995||Tsukamoto; Kenichi||Ultrasonic system to alleviate toothaches|
|US5515841 *||Nov 21, 1994||May 14, 1996||Minnesota Mining And Manufacturing Company||Inhaler|
|US5515842 *||Aug 8, 1994||May 14, 1996||Disetronic Ag||Inhalation device|
|US5516043||Jun 30, 1994||May 14, 1996||Misonix Inc.||Ultrasonic atomizing device|
|US5520166||Apr 28, 1995||May 28, 1996||Aradigm Corporation||Medication cassette for an automatic aerosol medication delivery system|
|US5520612||Dec 30, 1994||May 28, 1996||Exogen, Inc.||Acoustic system for bone-fracture therapy|
|US5527350||Feb 24, 1993||Jun 18, 1996||Star Medical Technologies, Inc.||Pulsed infrared laser treatment of psoriasis|
|US5529572||Jan 21, 1993||Jun 25, 1996||Medispec Ltd.||Method and apparatus particularly useful for treating osteoporosis|
|US5545124||May 5, 1994||Aug 13, 1996||Siemens Aktiengesellschaft||Method for alleviating the sensation of pain|
|US5551416||Nov 12, 1992||Sep 3, 1996||Medix Limited||Nebuliser and nebuliser control system|
|US5554172||May 9, 1995||Sep 10, 1996||The Larren Corporation||Directed energy surgical method and assembly|
|US5556372||Feb 15, 1995||Sep 17, 1996||Exogen, Inc.||Apparatus for ultrasonic bone treatment|
|US5573497||Feb 28, 1995||Nov 12, 1996||Technomed Medical Systems And Institut National||High-intensity ultrasound therapy method and apparatus with controlled cavitation effect and reduced side lobes|
|US5616140||Mar 21, 1994||Apr 1, 1997||Prescott; Marvin||Method and apparatus for therapeutic laser treatment|
|US5626554||Feb 21, 1995||May 6, 1997||Exogen, Inc.||Gel containment structure|
|US5643179||Dec 28, 1994||Jul 1, 1997||Kabushiki Kaisha Toshiba||Method and apparatus for ultrasonic medical treatment with optimum ultrasonic irradiation control|
|US5656016||Mar 18, 1996||Aug 12, 1997||Abbott Laboratories||Sonophoretic drug delivery system|
|US5658323||Oct 23, 1995||Aug 19, 1997||Miller; Iain D.||Method and apparatus for dermatology treatment|
|US5699805||Jun 20, 1996||Dec 23, 1997||Mayo Foundation For Medical Education And Research||Longitudinal multiplane ultrasound transducer underfluid catheter system|
|US5707402||Sep 6, 1996||Jan 13, 1998||Team Medical, L.L.C.||Directed energy surgical method and assembly|
|US5707403||Apr 23, 1996||Jan 13, 1998||Star Medical Technologies, Inc.||Method for the laser treatment of subsurface blood vessels|
|US5730705||Jun 12, 1996||Mar 24, 1998||Talish; Roger J.||Ultrasonic treatment for bony ingrowth|
|US5735811||Nov 30, 1995||Apr 7, 1998||Pharmasonics, Inc.||Apparatus and methods for ultrasonically enhanced fluid delivery|
|US5743863||Oct 2, 1996||Apr 28, 1998||Technomed Medical Systems And Institut National||High-intensity ultrasound therapy method and apparatus with controlled cavitation effect and reduced side lobes|
|US5752924||Aug 2, 1996||May 19, 1998||Orthologic Corporation||Ultrasonic bone-therapy apparatus and method|
|US5762616||Mar 15, 1996||Jun 9, 1998||Exogen, Inc.||Apparatus for ultrasonic treatment of sites corresponding to the torso|
|US5785972||Jan 10, 1997||Jul 28, 1998||Tyler; Kathleen A.||Colloidal silver, honey, and helichrysum oil antiseptic composition and method of application|
|US5835678||Jul 9, 1997||Nov 10, 1998||Emcore Corporation||Liquid vaporizer system and method|
|US5843139||Mar 12, 1997||Dec 1, 1998||Medtronic, Inc.||Adaptive, performance-optimizing communication system for communicating with an implanted medical device|
|US5879314||Sep 2, 1997||Mar 9, 1999||Cybersonics, Inc.||Transducer assembly and method for coupling ultrasonic energy to a body for thrombolysis of vascular thrombi|
|US5879364||Sep 30, 1997||Mar 9, 1999||Ethicon Endo-Surgery, Inc.||Internal ultrasonic tip amplifier|
|US5882302||Jun 24, 1996||Mar 16, 1999||Ths International, Inc.||Methods and devices for providing acoustic hemostasis|
|US5894841||Jun 28, 1994||Apr 20, 1999||Ponwell Enterprises Limited||Dispenser|
|US5947921||Dec 18, 1995||Sep 7, 1999||Massachusetts Institute Of Technology||Chemical and physical enhancers and ultrasound for transdermal drug delivery|
|US5960792||Oct 27, 1995||Oct 5, 1999||Aradigm Corporation||Device for aerosolized delivery of peptide drugs|
|US5989245||Mar 31, 1997||Nov 23, 1999||Prescott; Marvin A.||Method and apparatus for therapeutic laser treatment|
|US6001069||May 1, 1998||Dec 14, 1999||Ekos Corporation||Ultrasound catheter for providing a therapeutic effect to a vessel of a body|
|US6014970||Jun 11, 1998||Jan 18, 2000||Aerogen, Inc.||Methods and apparatus for storing chemical compounds in a portable inhaler|
|US6024718||Sep 4, 1997||Feb 15, 2000||The Regents Of The University Of California||Intraluminal directed ultrasound delivery device|
|US6026808||Jun 7, 1999||Feb 22, 2000||Sheffield Pharmaceuticals, Inc.||Methods and apparatus for delivering aerosolized medication|
|US6027495||Mar 20, 1997||Feb 22, 2000||Esc Medical Systems Ltd.||Method and apparatus for dermatology treatment|
|US6041253||Apr 1, 1996||Mar 21, 2000||Massachusetts Institute Of Technology||Effect of electric field and ultrasound for transdermal drug delivery|
|US6061597||Dec 18, 1998||May 9, 2000||Robert D. Rieman||Method and device for healing bone fractures|
|US6076519||Nov 4, 1996||Jun 20, 2000||Ethex International, Inc.||Passive inspiratory nebulizer system|
|US6083159||Jun 4, 1999||Jul 4, 2000||Ths International, Inc.||Methods and devices for providing acoustic hemostasis|
|US6095141||Jun 7, 1999||Aug 1, 2000||Sheffield Pharmaceuticals, Inc.||Methods and apparatus for delivering aerosolized medication|
|US6098620||Oct 27, 1995||Aug 8, 2000||Aradigm Corporation||Device for aerosolizing narcotics|
|US6102298||Feb 23, 1998||Aug 15, 2000||The Procter & Gamble Company||Ultrasonic spray coating application system|
|US6104952||Mar 20, 1999||Aug 15, 2000||Tu; Lily Chen||Devices for treating canker sores, tissues and methods thereof|
|US6106547||Sep 22, 1998||Aug 22, 2000||Huei-Jung; Lien||Hot/cold dual-mold skin treatment apparatus|
|US6113558||Sep 29, 1997||Sep 5, 2000||Angiosonics Inc.||Pulsed mode lysis method|
|US6113570||May 13, 1997||Sep 5, 2000||Coraje, Inc.||Method of removing thrombosis in fistulae|
|US6176839||Jul 22, 1998||Jan 23, 2001||Hmt High Medical Technologies Ag||Method and system for treatment with acoustic shock waves|
|US6186963||Apr 30, 1998||Feb 13, 2001||Hmt Holding Ag||Device for generating acoustic shock waves, especially for medical applications|
|US6190315||Jan 8, 1999||Feb 20, 2001||Sontra Medical, Inc.||Sonophoretic enhanced transdermal transport|
|US6190336||Mar 19, 1999||Feb 20, 2001||Exogen, Inc.||Ultrasonic treatment for wounds|
|US6206842||Aug 3, 1998||Mar 27, 2001||Lily Chen Tu||Ultrasonic operation device|
|US6206843||Jan 28, 1999||Mar 27, 2001||Ultra Cure Ltd.||Ultrasound system and methods utilizing same|
|US6231528||Jan 15, 1999||May 15, 2001||Jonathan J. Kaufman||Ultrasonic and growth factor bone-therapy: apparatus and method|
|US6234990||Jun 30, 1997||May 22, 2001||Sontra Medical, Inc.||Ultrasound enhancement of transdermal transport|
|US6251099||Nov 26, 1997||Jun 26, 2001||The General Hospital Corporation||Compound delivery using impulse transients|
|US6273864||Mar 19, 1999||Aug 14, 2001||Exogen, Inc.||Ultrasonic treatment for wounds|
|US6296630||Feb 25, 1999||Oct 2, 2001||Biocardia, Inc.||Device and method to slow or stop the heart temporarily|
|US6321109||Feb 14, 1997||Nov 20, 2001||Biosense, Inc.||Catheter based surgery|
|US6322527||Oct 18, 1999||Nov 27, 2001||Exogen, Inc.||Apparatus for ultrasonic bone treatment|
|US6325769||Jun 28, 1999||Dec 4, 2001||Collapeutics, Llc||Method and apparatus for therapeutic treatment of skin|
|USRE36939||May 30, 1996||Oct 31, 2000||Ekos Corporation||Composition for therapy of diseases with ultrasonic and pharmaceutical liquid composition containing the same|
|EP0437155B1||Feb 20, 1990||Feb 15, 1995||LABORATOIRES ANIOS, Société Anonyme||Method for spraying a liquid solution by ultrasound, and droplet diffuser for this method|
|EP0657226B1||Nov 28, 1994||Feb 4, 1998||Siemens Aktiengesellschaft||Ultrasonic sprayer|
|GB2099710A *||Title not available|
|GB2101500A *||Title not available|
|JP2000237275A||Title not available|
|1||Design and Application of Low-Frequency Ultrasound and Its Combination With Laser Radiation in Surgery and Therapy-Critical Reviews in Biomedical Engineering; 2001; pp. 502-519.|
|2||Design and Application of Low-Frequency Ultrasound and Its Combination With Laser Radiation in Surgery and Therapy—Critical Reviews in Biomedical Engineering; 2001; pp. 502-519.|
|3||Journal of Burn Care & Rehabilitation; vol. 21, No. 4; Jul./Aug. 2000 pp. 333-338.|
|Citing Patent||Filing date||Publication date||Applicant||Title|
|US6805301 *||Feb 4, 2002||Oct 19, 2004||Valois S.A.||Fluid product dispenser|
|US6964647 *||Oct 6, 2000||Nov 15, 2005||Ellaz Babaev||Nozzle for ultrasound wound treatment|
|US7600511 *||Oct 13, 2009||Novartis Pharma Ag||Apparatus and methods for delivery of medicament to a respiratory system|
|US7608275||Oct 27, 2009||The Foundry, Llc||Systems and methods for delivery of a therapeutic agent|
|US7655243||May 18, 2007||Feb 2, 2010||The Foundry, Llc||Methods and systems for toxin delivery to the nasal cavity|
|US7662177||Apr 12, 2006||Feb 16, 2010||Bacoustics, Llc||Apparatus and methods for pain relief using ultrasound waves in combination with cryogenic energy|
|US7713218||Jun 27, 2005||May 11, 2010||Celleration, Inc.||Removable applicator nozzle for ultrasound wound therapy device|
|US7753285||Jul 13, 2007||Jul 13, 2010||Bacoustics, Llc||Echoing ultrasound atomization and/or mixing system|
|US7780095||Aug 24, 2010||Bacoustics, Llc||Ultrasound pumping apparatus|
|US7785277||Jun 23, 2006||Aug 31, 2010||Celleration, Inc.||Removable applicator nozzle for ultrasound wound therapy device|
|US7785278||Sep 18, 2007||Aug 31, 2010||Bacoustics, Llc||Apparatus and methods for debridement with ultrasound energy|
|US7830070||Nov 9, 2010||Bacoustics, Llc||Ultrasound atomization system|
|US7842249||Nov 30, 2010||Bacoustics, Llc||Apparatus for vaccine development using ultrasound technology|
|US7846341||Dec 7, 2010||Bacoustics, Llc||Method of ultrasonically treating a continuous flow of fluid|
|US7878991||Feb 1, 2011||Bacoustics, Llc||Portable ultrasound device for the treatment of wounds|
|US7883031||May 20, 2004||Feb 8, 2011||James F. Collins, Jr.||Ophthalmic drug delivery system|
|US7896539||Mar 1, 2011||Bacoustics, Llc||Ultrasound apparatus and methods for mixing liquids and coating stents|
|US7896854||Mar 1, 2011||Bacoustics, Llc||Method of treating wounds by creating a therapeutic solution with ultrasonic waves|
|US7896855||Dec 19, 2007||Mar 1, 2011||Bacoustics, Llc||Method of treating wounds by creating a therapeutic combination with ultrasonic waves|
|US7901388||Mar 8, 2011||Bacoustics, Llc||Method of treating wounds by creating a therapeutic solution with ultrasonic waves|
|US7914470||Mar 29, 2011||Celleration, Inc.||Ultrasonic method and device for wound treatment|
|US7943352||Mar 29, 2006||May 17, 2011||Bacoustics, Llc||Apparatus and methods for vaccine development using ultrasound technology|
|US7950594||May 31, 2011||Bacoustics, Llc||Mechanical and ultrasound atomization and mixing system|
|US7971588||Jul 5, 2011||Novartis Ag||Methods and systems for operating an aerosol generator|
|US8002736||Dec 19, 2008||Aug 23, 2011||Carticept Medical, Inc.||Injection systems for delivery of fluids to joints|
|US8007487||Aug 30, 2011||Carticept Medical, Inc.||Method of treating a joint using an articular injection system|
|US8012136||Sep 6, 2011||Optimyst Systems, Inc.||Ophthalmic fluid delivery device and method of operation|
|US8016208||Sep 13, 2011||Bacoustics, Llc||Echoing ultrasound atomization and mixing system|
|US8050752||Nov 1, 2011||Bacoustics, Llc||Method of treating lumens, cavities, and tissues of the body with an ultrasound delivered liquid|
|US8079976||Dec 22, 2008||Dec 20, 2011||Carticept Medical, Inc.||Articular injection system|
|US8088127||May 8, 2009||Jan 3, 2012||Innovative Pulmonary Solutions, Inc.||Systems, assemblies, and methods for treating a bronchial tree|
|US8105817||Jan 31, 2012||The Foundry Llc||Methods and systems for toxin delivery to the nasal cavity|
|US8122880 *||Dec 18, 2000||Feb 28, 2012||Palo Alto Research Center Incorporated||Inhaler that uses focused acoustic waves to deliver a pharmaceutical product|
|US8133497||Sep 14, 2009||Mar 13, 2012||The Foundry, Llc||Systems and methods for delivery of a therapeutic agent|
|US8142414||Mar 27, 2012||Carticept Medical, Inc.||Methods of injecting fluids into joints using a handpiece assembly|
|US8172827||May 8, 2012||Innovative Pulmonary Solutions, Inc.||Apparatus for treating asthma using neurotoxin|
|US8196573||Jun 12, 2012||Novartis Ag||Methods and systems for operating an aerosol generator|
|US8226638||Jul 24, 2012||Innovative Pulmonary Solutions, Inc.||Systems, assemblies, and methods for treating a bronchial tree|
|US8235919||Apr 7, 2003||Aug 7, 2012||Celleration, Inc.||Ultrasonic method and device for wound treatment|
|US8336545||Jan 16, 2007||Dec 25, 2012||Novartis Pharma Ag||Methods and systems for operating an aerosol generator|
|US8338164||Dec 25, 2012||The Foundry, Llc||Systems and methods for delivery of a therapeutic agent|
|US8357696||Jan 28, 2010||Jan 22, 2013||Mpex Pharmaceuticals, Inc.||Aerosolized fluoroquinolones and uses thereof|
|US8425463||Jun 11, 2012||Apr 23, 2013||Carticept Medical, Inc.||Anesthetic injection system|
|US8425464||Jun 11, 2012||Apr 23, 2013||Carticept Medical, Inc.||Imaging-guided anesthetic injection method|
|US8483831||Feb 17, 2009||Jul 9, 2013||Holaira, Inc.||System and method for bronchial dilation|
|US8489192||Jun 14, 2012||Jul 16, 2013||Holaira, Inc.||System and method for bronchial dilation|
|US8491521||Jul 17, 2008||Jul 23, 2013||Celleration, Inc.||Removable multi-channel applicator nozzle|
|US8524734||Oct 22, 2009||Sep 3, 2013||Mpex Pharmaceuticals, Inc.||Aerosolized fluoroquinolones and uses thereof|
|US8524735||Oct 22, 2009||Sep 3, 2013||Mpex Pharmaceuticals, Inc.||Aerosolized fluoroquinolones and uses thereof|
|US8545440||Jun 24, 2010||Oct 1, 2013||Carticept Medical, Inc.||Injection system for delivering multiple fluids within the anatomy|
|US8545463||Jan 26, 2007||Oct 1, 2013||Optimyst Systems Inc.||Ophthalmic fluid reservoir assembly for use with an ophthalmic fluid delivery device|
|US8546423||Oct 22, 2009||Oct 1, 2013||Mpex Pharmaceuticals, Inc.||Aerosolized fluoroquinolones and uses thereof|
|US8562547||Apr 1, 2008||Oct 22, 2013||Eliaz Babaev||Method for debriding wounds|
|US8629139||Oct 6, 2009||Jan 14, 2014||Mpex Pharmaceuticals, Inc.||Topical use of Levofloxacin for reducing lung inflammation|
|US8636684||Dec 16, 2011||Jan 28, 2014||The Foundry Llc||Methods and systems for toxin delivery to the nasal cavity|
|US8684980||Jul 15, 2011||Apr 1, 2014||Corinthian Ophthalmic, Inc.||Drop generating device|
|US8731672||Jun 18, 2013||May 20, 2014||Holaira, Inc.||System and method for bronchial dilation|
|US8733935||Jul 15, 2011||May 27, 2014||Corinthian Ophthalmic, Inc.||Method and system for performing remote treatment and monitoring|
|US8740895||Jun 28, 2013||Jun 3, 2014||Holaira, Inc.||Delivery devices with coolable energy emitting assemblies|
|US8777943||Jun 28, 2013||Jul 15, 2014||Holaira, Inc.||Delivery devices with coolable energy emitting assemblies|
|US8808280||Apr 20, 2012||Aug 19, 2014||Holaira, Inc.||Systems, assemblies, and methods for treating a bronchial tree|
|US8815838||Oct 6, 2009||Aug 26, 2014||David C. Griffith||Aerosol fluoroquinolone formulations for improved pharmacokinetics|
|US8821489||Apr 20, 2012||Sep 2, 2014||Holaira, Inc.||Systems, assemblies, and methods for treating a bronchial tree|
|US8875702 *||Aug 30, 2010||Nov 4, 2014||The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services, Centers For Disease Control And Prevention||Aerosol generator|
|US8911439||Nov 11, 2010||Dec 16, 2014||Holaira, Inc.||Non-invasive and minimally invasive denervation methods and systems for performing the same|
|US8932289||Sep 26, 2011||Jan 13, 2015||Holaira, Inc.||Delivery devices with coolable energy emitting assemblies|
|US8936021||Oct 6, 2008||Jan 20, 2015||Optimyst Systems, Inc.||Ophthalmic fluid delivery system|
|US8961391||Oct 25, 2012||Feb 24, 2015||The Foundry, Llc||Systems and methods for delivery of a therapeutic agent|
|US8961507||Apr 20, 2012||Feb 24, 2015||Holaira, Inc.||Systems, assemblies, and methods for treating a bronchial tree|
|US8961508||Apr 20, 2012||Feb 24, 2015||Holaira, Inc.||Systems, assemblies, and methods for treating a bronchial tree|
|US9005195||Sep 26, 2011||Apr 14, 2015||Holaira, Inc.||Delivery devices with coolable energy emitting assemblies|
|US9017324||Jun 28, 2013||Apr 28, 2015||Holaira, Inc.||Delivery devices with coolable energy emitting assemblies|
|US9044542||Jun 11, 2012||Jun 2, 2015||Carticept Medical, Inc.||Imaging-guided anesthesia injection systems and methods|
|US9067015||Sep 27, 2013||Jun 30, 2015||Carticept Medical, Inc.||System for injecting fluids in a subject|
|US9087145||Jul 15, 2011||Jul 21, 2015||Eyenovia, Inc.||Ophthalmic drug delivery|
|US9101949||Dec 13, 2006||Aug 11, 2015||Eilaz Babaev||Ultrasonic atomization and/or seperation system|
|US9125643||Apr 30, 2014||Sep 8, 2015||Holaira, Inc.||System and method for bronchial dilation|
|US9149328||Nov 11, 2010||Oct 6, 2015||Holaira, Inc.||Systems, apparatuses, and methods for treating tissue and controlling stenosis|
|US20020073990 *||Dec 18, 2000||Jun 20, 2002||Xerox Corporation||Inhaler that uses focused acoustic waves to deliver a pharmaceutical product|
|US20020104895 *||Feb 4, 2002||Aug 8, 2002||Firmin Garcia||Fluid product dispenser|
|US20050075620 *||Jan 22, 2002||Apr 7, 2005||Yoni Iger||Method and apparatus for the delivery of substances to biological components|
|US20060225742 *||Jun 1, 2006||Oct 12, 2006||The Foundry, Inc.||Apparatus for treating asthma using neurotoxin|
|US20070025919 *||Jul 21, 2006||Feb 1, 2007||The Foundry Inc.||Systems and methods for delivery of a therapeutic agent|
|US20070167824 *||Jan 11, 2006||Jul 19, 2007||Warren Lee||Method of manufacture of catheter tips, including mechanically scanning ultrasound probe catheter tip, and apparatus made by the method|
|US20070167825 *||Jan 11, 2006||Jul 19, 2007||Warren Lee||Apparatus for catheter tips, including mechanically scanning ultrasound probe catheter tip|
|US20070219481 *||Mar 16, 2006||Sep 20, 2007||Eilaz Babaev||Apparatus and methods for the treatment of avian influenza with ultrasound|
|US20070267011 *||May 18, 2007||Nov 22, 2007||The Foundry Inc.||Apparatus for toxin delivery to the nasal cavity|
|US20080004649 *||Sep 18, 2007||Jan 3, 2008||Bacoustics Llc||Apparatus and methods for debridement with ultrasound energy|
|US20080051693 *||Aug 31, 2007||Feb 28, 2008||Bacoustics Llc||Portable Ultrasound Device for the Treatment of Wounds|
|US20080082039 *||Sep 29, 2006||Apr 3, 2008||Eilaz Babaev||Ultrasound Liquid Delivery Device|
|US20080095920 *||Dec 18, 2007||Apr 24, 2008||Eilaz Babaev||Ultrasound medical device coating method|
|US20080119779 *||Sep 29, 2006||May 22, 2008||Eilaz Babaev||Method of Treating Lumens, Cavities, and Tissues of the Body with an Ultrasound Delivered Liquid.|
|US20080128362 *||Dec 4, 2006||Jun 5, 2008||Bacoustics Llc||Method of ultrasonically treating a continuous flow of fluid|
|US20080139943 *||Dec 7, 2006||Jun 12, 2008||Industrial Technology Research Institute||Ultrasonic wave device|
|US20080177220 *||Jan 8, 2007||Jul 24, 2008||The Curators Of The University Of Missouri||Ultrasound-Mediated Transcleral Drug Delivery|
|US20080243047 *||Mar 27, 2007||Oct 2, 2008||Babaev Eilaz P||Ultrasound wound care device|
|US20090200390 *||Feb 12, 2008||Aug 13, 2009||Eilaz Babaev||Ultrasound atomization system|
|US20090200396 *||Feb 11, 2008||Aug 13, 2009||Eilaz Babaev||Mechanical and ultrasound atomization and mixing system|
|US20100087775 *||Apr 8, 2010||The Foundy, Llc||Methods and systems for toxin delivery to the nasal cavity|
|US20110108023 *||May 12, 2011||The Government Of The United States Of America, As Represented By The Secretary, Department Of Hea||Aerosol generator|
|US20110226235 *||Nov 21, 2009||Sep 22, 2011||Koninklijke Philips Electronics, N.V.||System and method for monitoring nebulization of a medicament|
|EP2594272A2||May 18, 2006||May 22, 2013||Mpex Pharmaceuticals, Inc.||Aerosolized fluoroquinolones and uses thereof|
|WO2007014003A2||Jul 21, 2006||Feb 1, 2007||The Foundry Inc.||Systems and methods for delivery of a therapeutic agent|
|WO2007021427A2||Jul 18, 2006||Feb 22, 2007||Babaev Eilaz P||Ultrasound apparatus and methods for mixing liquids and coating stents|
|WO2007070957A1 *||Dec 20, 2006||Jun 28, 2007||Monash University||Process and apparatus for generating particles|
|U.S. Classification||128/200.16, 239/102.2, 604/58|
|International Classification||A61M15/00, A61M11/00|
|Cooperative Classification||A61M11/005, A61M15/0085, A61M11/001, A61M2205/8206, A61M2205/8262|
|Jun 11, 2002||AS||Assignment|
Owner name: ADVANCED MEDICAL APPLICATIONS, INC., MINNESOTA
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:BABAEV, EILAZ;REEL/FRAME:012986/0035
Effective date: 20020521
|Apr 7, 2003||AS||Assignment|
Owner name: TRANSAMERICA TECHNOLOGY FINANCE CORPORATION, CONNE
Free format text: SECURITY INTEREST;ASSIGNOR:CELLERATION, INC.;REEL/FRAME:013907/0846
Effective date: 20030327
|Feb 5, 2007||FPAY||Fee payment|
Year of fee payment: 4
|Mar 30, 2007||AS||Assignment|
Owner name: CELLERATION, INC., MINNESOTA
Free format text: CHANGE OF NAME;ASSIGNOR:ADVANCED MEDICAL APPLICATIONS, INC.;REEL/FRAME:019102/0655
Effective date: 20020730
Owner name: CELLERATION, INC., MINNESOTA
Free format text: MERGER;ASSIGNOR:CELLERATION, INC.;REEL/FRAME:019094/0591
Effective date: 20030506
|Sep 23, 2008||AS||Assignment|
Owner name: CELLERATION, INC., MINNESOTA
Free format text: RELEASE BY SECURED PARTY;ASSIGNOR:GE TECHNOLOGY FINANCE CORPORATION;REEL/FRAME:021561/0802
Effective date: 20080905
|Feb 7, 2011||FPAY||Fee payment|
Year of fee payment: 8
|Feb 5, 2015||FPAY||Fee payment|
Year of fee payment: 12
|May 29, 2015||AS||Assignment|
Owner name: PERCEPTIVE CREDIT OPPORTUNITIES FUND, LP C/O PERCE
Free format text: SECURITY INTEREST;ASSIGNOR:ALQA CEDAR, INC.;REEL/FRAME:035745/0313
Effective date: 20150529
|Jul 21, 2015||AS||Assignment|
Owner name: ALLIQUA BIOMEDICAL, INC., PENNSYLVANIA
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:CELLERATION, INC.;REEL/FRAME:036140/0913
Effective date: 20150721
|Mar 28, 2016||AS||Assignment|
Owner name: ALLIQUA BIOMEDICAL, INC., PENNSYLVANIA
Free format text: CHANGE OF ASSIGNEE ADDRESS;ASSIGNOR:CELLERATION, INC.;REEL/FRAME:038274/0778
Effective date: 20150721