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Publication numberUS671804 A
Publication typeGrant
Publication dateApr 9, 1901
Filing dateMay 28, 1900
Priority dateDec 2, 1899
Publication numberUS 671804 A, US 671804A, US-A-671804, US671804 A, US671804A
InventorsFrederick H Metcalf
Original AssigneeFrederick H Metcalf
Export CitationBiBTeX, EndNote, RefMan
External Links: USPTO, USPTO Assignment, Espacenet
Coated pill, &c.
US 671804 A
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Description  (OCR text may contain errors)

Patented Apr. 9, I90L n vantoz f regge f 4 0019/7 MQW N RIS PETERS CO.. PNDTGLITHD.. WAIMINGTON, D. L

(No Model) Wihwooe /l Vfg/f UNITED STATES FREDERICK H. METCALF,

PATENT OFFICE.

OF FRANKLIN, ILLINOIS.

COATED PILL, Sac.

SPECIFICATION formingpart of Letters Patent No. 671,804, dated April 9, 1901. Original application filed December 2, 1899, Serial No. 738,993. Divided and this application filed May 28, 1900. Serial fication.

This invention relates to improvements in coated pills, tablets, lozenges, and the like, and forms part of a divisional application filed December 2, 1899, Serial No. 738,993, allowed May 2, 1900, and patented under No. 650,760.

One object of this improvement is to mix with the coating used in the manufacture of coated pills a sulcient quantity of pepsin to quickly dissolve said coating and make the medicine which is incased more susceptible to the digestive organs when taken into the stomach.

A further object of the improvement is to mix a sufficient quantity of pepsin with the coating for pills when said coating consists primarily of gelatin so as to assist the stornach to quickly and readily digest the coating to permit the exposure of the incased medical compound to the digestive organs.

Many other objects and advantages will be apparent upon further description.

In the drawiri gs forming a part of this specification, Figure l is a sectional view of a pill, showing my improvement applied thereto. Fig. 2 is a similar view showing a modified form of my invention.

Referring to the drawings, the numeral 1 represents a pill as a whole, composed of any suitable medical compound 2 and provided with a coating 3. Mixed with the coating is a sufficient quantity of pepsin or other digestive agent 4.

In the manufacture of pills, tablets, or lozenges for certain reasons it is necessary to provide a coating. In some cases this coating is composed of a mixture which is not readily susceptible to the digestive organs of the stomach; and it is the purpose and objectY of this invention to introduce in its composition a sucient quantity of pepsin so asto enable the stomach to readily 'and quickly reduce the coating and expose the incased medical compound. The coatings for pills, as

(No model.)

before stated, are largely made up of a gelatinous substance, and it is well known this substance is exceedingly difficult to digest, and it not infrequently occurs that a gelatincoated pill absolutely refuses to be subjected to the digestive organs and juices of the stomach, and as a result the pill is taken without any curative result.

While I am aware that the coating of pills is largely gelatin, I am also aware of other substances being used equally as hard to digest and propose to mix pepsin with my coating solution used for pills.

The pepsin is applied to the pill, tablet, or lozenge preferably when the coating is ina liquid state. However, a separate compartment may be made, as disclosed in Fig. 2. In this modification the pepsin is contained between two layers of coating, the outer one of which is thinner than the inner, so much so as to not be a barrier to the juices.

In many cases I may apply enough pepsin to not only reduce the coating around the pill, but to coact with the compound incased within the coating and assist in its digestion.

Having thus described my invention, what I claim isl l. As a new article of manufacture, a pill, tablet or lozenge provided with a gelatinous coating, said coating having pepsin distributed throughout its composition to assist the digestion of said'coating and the rapid liberation of the compound forming the pill, whereby the juices of the stomach, may have immediate action on said compound, substantially as described.

2. As a new article of manufacture, a pill, tablet or lozenge, provided with a gelatinous coating having pepsin uniformly distributed throughout its composition to assist the digestion of said coating and the rapid liberation of the compound forming the pill, whereby the juices of the stomach may have immediate action on said compound, substantially as described.

In testimony whereof I have hereunto set my hand in the presence of two subscribing witnesses.

FREDERICK H. METOALF. Witnesses:

CHARLES A. BARNES, LENA C. ENGEL.

Referenced by
Citing PatentFiling datePublication dateApplicantTitle
US3181998 *Aug 12, 1960May 4, 1965Kanig Joseph LTablet disintegration
US3493652 *Sep 14, 1962Feb 3, 1970Hartman Charles WControlled release medicament
US3943238 *Oct 29, 1973Mar 9, 1976Meija Seika Co., Ltd.Gelatin, mideamycin
US4261969 *May 3, 1979Apr 14, 1981World Health OrganizationControlled drug release composition
US4820524 *Feb 20, 1987Apr 11, 1989Mcneilab, Inc.Gelatin coated caplets and process for making same
US4966771 *May 5, 1988Oct 30, 1990Mcneilab, Inc.Dipping and drying first one end and then the other to provide a smooth coating easy to swallow; tamper-proof
US5314537 *May 5, 1988May 24, 1994Mcneilab, Inc.Gelatin coated caplets and process for making same
US5314696 *Jun 27, 1991May 24, 1994Paulos Manley AMethods for making and administering a blinded oral dosage form and blinded oral dosage form therefor
US5558878 *Apr 15, 1994Sep 24, 1996Captab, L.L.C.Encapsulation
US5576019 *Jun 7, 1995Nov 19, 1996Captab 11CForming tablets and capsules for drugs from cylinders and caps
US5750145 *Jul 28, 1995May 12, 1998Bristol-Myers Squibb CompanyStable gelatin coated aspirin tablets
Classifications
Cooperative ClassificationA61K9/2873