Search Images Maps Play YouTube News Gmail Drive More »
Sign in
Screen reader users: click this link for accessible mode. Accessible mode has the same essential features but works better with your reader.

Patents

  1. Advanced Patent Search
Publication numberUS6824704 B2
Publication typeGrant
Application numberUS 10/684,472
Publication dateNov 30, 2004
Filing dateOct 15, 2003
Priority dateOct 29, 1998
Fee statusPaid
Also published asUS6555020, US20030170592, US20040079920
Publication number10684472, 684472, US 6824704 B2, US 6824704B2, US-B2-6824704, US6824704 B2, US6824704B2
InventorsThomas C. Chadwick, Heather L. Hunt
Original AssigneeThe Gillette Company
Export CitationBiBTeX, EndNote, RefMan
External Links: USPTO, USPTO Assignment, Espacenet
Stable tooth whitening gels containing high percentages of hydrogen peroxide
US 6824704 B2
Abstract
An aqueous gel useful for bleaching teeth comprising: (i) water; (ii) polyacrylic acid thickening agent; (iii) hydrogen peroxide bleaching agent; and (iv) aminocarboxylic acid/salt stabilizing agent. Preferably the polyacrylic acid is an easy to disperse carbomer and the gels contain high concentrations (20 to 40% by weight) of hydrogen peroxide. The gels exhibit room temperature stability, both with respect to gel stability and hydrogen peroxide decomposition, sufficient to eliminate the need for constant refrigeration. A method for using the gels to bleach teeth is also disclosed.
Images(6)
Previous page
Next page
Claims(3)
What is claimed is:
1. A method for bleaching teeth comprising the following steps:
(a) protecting the soft tissue surrounding the teeth with a covering;
(b) applying an aqueous dental bleaching gel to the teeth that comprises:
(i) water;
(ii) a polyacrylic acid thickening agent;
(iii) at least one bleaching agent selected from the group consisting of hydrogen peroxide and compounds that release hydrogen peroxide in water; and
(iv) a stabilizing agent selected from the group consisting of EDTA, CDTA, and a salt thereof,
wherein said bleaching agent is present in an amount ranging from about 20% to about 50% by weight, and wherein said polyacrylic acid thickening agent and said stabilizing agent are added in a weight ratio within the range of about 3.3:1 to about 3.5:1 that maintains said aqueous gel in a suitable gel form for 4 to 12 weeks at room temperature in a syringe plunger without self-expelling; and
(c) removing the dental bleaching gel.
2. The method of claim 1 wherein the dental bleaching gel remains in contact with the teeth for a period of 5 to 60 minutes.
3. The method of claim 2 wherein the dental bleaching gel is applied to the teeth and then treated with a laser light or heat lamp prior to removal.
Description
RELATED APPLICATIONS

This application is a continuation of and claims priority to U.S. patent application Ser. No. 10/386,656 filed Mar. 13, 2003, which is a divisional of and claims priority to U.S. patent application Ser. No. 09/428,910 filed Oct. 28, 1999, now U.S. Pat. No. 6,555,020, which claims priority to U.S. Provisional Application Ser. No. 60/106,076 filed Oct. 29, 1998.

TECHNICAL FIELD

This invention pertains to bleaching gels for use in bleaching teeth. More specifically this invention relates to the production of stable aqueous bleaching gels that contain a very high percentage of hydrogen peroxide and methods for their use in bleaching teeth.

BACKGROUND ART

A gel is a colloid produced by combining a dispersed phase with a continuous phase (i.e. a dispersion medium or matrix) to produce a viscous, jelly-like, semisolid material. In the dental industry, gels are utilized as vehicles for applying a variety of dentifrices, bleaching aids, and fluoride compounds to teeth. A “dental bleaching gel” is a gel that carries a bleaching agent that can be safely applied to teeth.

Hydrogen peroxide has become the bleaching agent of choice for use in dental bleaching gels. Hydrogen peroxide is a powerful oxidizer which serves to bleach the colored materials in the teeth, thereby, producing a whiter appearance.

Unfortunately, at room temperature, hydrogen peroxide will attack the gelling agents used to make the dental bleaching gels. As a result of this attack, the gelling agents break down over time. Eventually, the gelling agents break down to such a degree that the gel's viscosity becomes too low to be suitable.

Viscosity is very important to the effectiveness of dental bleaching gels. If the viscosity is too low, the gel will flow uncontrollably from the dispensing tube and become difficult to manipulate for the purposes of varying or equalizing the bleaching treatment applied to the teeth. More importantly, if the viscosity is too low, the gel is more likely to flow away from the teeth, resulting in a reduced residence time. Residence time is the time the dental bleaching gel actually contacts the tooth enamel. The effectiveness of a dental bleaching gel is directly proportional to its residence time.

In addition, hydrogen peroxide tends to decompose at room temperature. The rate of this decomposition is dependent upon many factors. The presence of various metallic impurities, such as iron, manganese, copper and chromium, catalyze the decomposition. Furthermore, the stability of hydrogen peroxide decreases with increasing alkalinity and temperature. Because the whitening ability of a dental bleaching gel depends on the hydrogen peroxide concentration, premature decomposition diminishes the ability of the gel to whiten.

To combat these problems, dental bleaching gels containing high concentrations of hydrogen peroxide are generally refrigerated until immediately prior to use. Refrigeration slows down the hydrogen peroxide attack on the gelling agent and also slows down hydrogen peroxide decomposition. However, refrigeration is both expensive and inconvenient.

Various stabilizing agents have been investigated in an attempt to develop hydrogen peroxide containing dental bleaching gels that are stable at room temperature. Unfortunately, to date, these stabilizing agents have either proven ineffective.

The instant invention solves these stability problems by providing, for the first time, an effective bleaching gel that is stable at room temperature and that contains a large concentration of hydrogen peroxide. There appears to be very little prior art that is relevant to this invention. The most relevant prior art known to the inventors includes the following:

U.S. Pat. Nos. 5,422,073, 5,500,186, 5,593,637 and 5,756,045 teach a method for disinfecting a contact lens which includes contacting the lens with an isotonic aqueous solution comprising 0.6 to 2 weight percent tromethamine. Other aspects include adding to the solution a chelating agent (preferably disodium EDTA) and/or additional microbicide. The microbicide may be a very low concentration of hydrogen peroxide, e.g., 50 to 200 ppm. The disodium EDTA is not used as a stabilizer for the hydrogen peroxide.

U.S. Pat. No. 5,759,440 teaches an aqueous solution (as opposed to a gel) of hydrogen peroxide stabilized by incorporation of a composition containing a mixture of an alkali metal pyrophosphate or alkaline earth metal pyrophosphate with a stabilizer belonging to the category of aminopolycarboxylic acids. The solution finds application for bleaching textiles and paper pulps.

U.S. Pat. No. 5,641,386 teaches a process for the bleaching of pulp comprising the step of bleaching the pulp with hydrogen peroxide and an effective amount of at least one biodegradable 1-amino-alkane-1,1-diphosphate chelating agent to enhance the bleaching of the pulp.

U.S. Pat. No. 4,812,173 teaches stabilized hydrogen peroxide disinfecting solutions containing diphosphoric acids (such as hydroxyethylidene diphosphoric acid), and glycerin.

U.S. Pat. No. 5,248,389 teaches a process for peroxygen bleaching of high yield pulp in which sodium carbonate replaces sodium hydroxide and sodium silicate.

U.S. Pat. Nos. 5,098,303, 5,376,006 and 5,725,843 teach high viscosity sustained release dental compositions, such as tooth bleaching or fluoride compositions, for treating tooth surfaces. The sustained release dental compositions include a high carboxypolymethylene concentration (typically greater than 3.5%) which results in very high viscosity. The bleaching gels can contain from about 3 to about 20% carbamide peroxide, preferably about 4% to about 15% carbamide peroxide. Alternatively, the bleaching gels can contain hydrogen peroxide in a preferred range of from about 2% to about 10%.

U.S. Pat. No. 4,226,851 teaches a stable dental hygiene composition comprising a mixture of hydrogen peroxide and zinc chloride. The mixture is stabilized by the addition of water soluble vitamin E.

Ultradent, produced by Ultradent Products of South Jordan, Utah, offers a 35% hydrogen peroxide bleaching gel product called Opalescence Xtra. The package contains a prominent warning which states “REFRIGERATION REQUIRED!” Similar warnings appear in two places on the package insert. Opalescence Xtra is a gel that is red in color due to the presence of β-carotene. Opalescence Xtra turns into a colorless, runny liquid in less than two weeks when stored at room temperature.

None of the aforementioned references describes the stabilization of gels with respect to both gel stability and hydrogen peroxide stability.

SUMMARY OF THE INVENTION

This invention is directed to aqueous gels useful for bleaching teeth comprising: (i) water; (ii) polyacrylic acid thickening agent; (iii) at least one bleaching agent selected from the group consisting of hydrogen peroxide and compounds that release hydrogen peroxide in water; and (iv) aminocarboxylic acid/salt stabilizing agent. Preferably the gel also comprises (v) a neutralizing agent that serves to neutralize the polyacrylic acid. Ideally, these gels are fast acting bleaching gels that contain 20 to 50% by weight bleaching agent.

The combination of polyacrylic acid thickener and the aminocarboxylic acid/salt stabilizer provides a gel that can be loaded with hydrogen peroxide and remain sufficiently stable to provide a suitable gel (from a viscosity standpoint) after 4 to 12 weeks storage at room temperature. In addition, the gels exhibit little hydrogen peroxide decomposition.

These gels may be applied by a method comprising the following steps: (a) protecting the soft tissue surrounding the teeth with a covering; (b) applying the aforementioned aqueous gel to the teeth; and (c) removing the gel. Preferably, prior to removal, the gel is treated with a laser or heat lamp to accelerate bleaching.

DISCLOSURE OF THE INVENTION

As stated, the instant invention is directed to aqueous gels that contain hydrogen peroxide and that are stable at room temperature for up to twelve weeks. These gels comprise: (i) water; (ii) thickening agent; (iii) bleaching agent; (iv) stabilizing agent; and, optionally, (v) neutralizing agent.

Water is the principle component of the aqueous gels. Preferably, water is present in an amount over 50% by weight. More preferably, water makes up the remainder of the gel after removal of the thickening agent, bleaching agent, stabilizing agent and neutralizing agent.

The thickening agent (a.k.a. gelling agent) is present in an amount ranging from 0.25% to 3% by weight of the aqueous gel. The thickening agent is a “polyacrylic acid” which means that it is selected from acrylic acid homopolymers and copolymers comprising 90% or more, by weight, polymerized acrylic acid units. The preferred acrylic acid monomer used to make these thickeners is the actual compound “acrylic acid.” However, other acrylic acids can also be employed, e.g. methacrylic acid and C1-4 alkyl substituted acrylic acid. Other comonomers that may be present in the polymer chain include 10% by weight or less long chain alkyl esters of acrylic acid.

Suitable thickeners include the crosslinked polyacrylic resins sold by B.F. Goodrich under the tradename CarbopolŽ. The USP-NF, British Pharmacopoeia, United States Adopted Names Council (USAN), and Cosmetic, Toiletries and Fragrance Association (CTFA) have adopted the generic (i.e. non-proprietary) name “carbomer” for the CarbopolŽ homopolymers. The Japanese Pharmaceutical Exipients list CarbopolŽ homopolymers as “carboxyvinyl polymer” and “carboxy polymethylene.” All of these polymers have the same acrylic acid backbone. The main differences are related to the presence of comonomer and crosslink density. These polymers are either homopolymers of acrylic acid crosslinked with allyl sucrose, polyalkyl ethers of divinyl glycol, or allyl pentaerythritol or similarly crosslinked copolymers of acrylic acid with minor levels of long chain alkyl acrylate comonomers. These polymers swell in water up to 1000 times their original volume (and ten times their original diameter) to form a gel when exposed to a pH environment above 4.0-6.0. CarbopolŽ thickeners are highly resistant to hydrolysis and oxidation under normal conditions.

Preferred thickeners include CarbopolŽ ETD™ 2001, CarbopolŽETD™2020, and CarbopolŽ ETD™ 2050. These “easy-to-disperse (ETD™)” thickeners are homopolymers or copolymers of acrylic acid, produced using a polymerization aid, and crosslinked with a polyalkenyl polyether. CarbopolŽ ETD™ 2001, CarbopolŽ ETD™ 2020, and CarbopolŽ ETD™ 2050 are easier to disperse and mix than other CarbopolŽ products. The thickeners wet quickly and thereby minimize lumping. By “wet” it is meant that the white particles of polymer fully disappear (disperse) into the mixture. The thickeners also hydrate slowly and have a lower viscosity prior to neutralization than other CarbopolŽ products. Because of the fast wetting nature and low viscosity of the thickeners, vigorous agitation is not necessary to disperse them. This is important to the instant invention since vigorous agitation is undesirable because it induces hydrogen peroxide decomposition. The fast wetting nature of the thickeners also aids handling. Once the ETD™ resins are neutralized, they provide the type of highly efficient thickening for which Carbopol resins are known.

The most preferred thickener is CarbopolŽ Ultrez™ 10. This thickener is an exceptionally easy-to-disperse polymer that wets even more quickly than the Carbopol ETD™ resins. In fact, CarbopolŽ Ultrez™ 10 wets without any stirring. For example, a 500 gram dispersion at 0.5% resin (2.5 grams) will take only about 5 minutes to completely wet without mixing. This decreases the time and effort necessary to achieve a lump-free dispersion.

The bleaching agent utilized in the aqueous gel is present in an amount ranging from 3 to 50%, preferably 20 to 50%, more preferably 30-40%, and most preferably 35% by weight of the aqueous gel. Higher amounts of bleaching agent are preferred so that the gel may serve as a “fast acting bleaching gel” capable of bleaching teeth with only one or two applications.

The bleaching agent may be selected from hydrogen peroxide (H2O2) or any compound that yields hydrogen peroxide when placed in an aqueous medium. In example, carbamide peroxide (CO(NH2)2H2O2) generates hydrogen peroxide when placed in water. Other names for carbamide peroxide include urea peroxide, urea hydrogen peroxide, hydrogen peroxide carbamide, and perhydrol urea.

The stabilizing agent utilized in the aqueous gel is present in an amount ranging from 0.05 to 0.5% by weight of the aqueous gel. An amount of approximately 0.15% stabilizer is preferred. The stabilizing agent is selected from aminocarboxylic acids and salts thereof. Preferred stabilizers are selected from aminocarboxylic acids and alkali and/or alkali earth metal salts thereof. Suitable aminocarboxylic acids include trans-1,2-cyclohexylene dinitrilotetraacetic acid (CDTA), ethylenediamine tetraacetic acid (EDTA), N-(2-hydroxyethyl) ethylenediamine triacetic acid (HEDTA), Nitrilotriacetic acid (NTA), diethylene triamine pentaacetic acid (DTPA), triethylene tetraamine hexaacetic acid (TTHA), and ethyleneglycol bis (2-aminoethylether) tetraacetic acid (GEDTA). The most preferred stabilizers include CDTA, CaNa2EDTA, Na2EDTA, Na4EDTA, HEDTA, and Na3HEDTA.

The combination of polyacrylic acid thickener and aminocarboxylic acid/salt stabilizer provides a gel that can be loaded with hydrogen peroxide and that is stable in the sense that it maintains a suitable gel for 4 to 12 weeks at room temperature. For example, a 3.4/1 ratio of polyacrylic acid/CaNa2EDTA yields an aqueous gel that is stable for 12 weeks, a 3.5/1 ratio of polyacrylic acid/CDTA yields an aqueous gel that is stable for 7 weeks, and a 0.3/1 ratio of polyacrylic acid/Na2EDTA yields a gel that is stable for 41/2 weeks. By “suitable gel” it is meant that when a drop of the gel is placed on the surface of a flat glass plate and the surface is turned vertically, the gel droplet remains in place on the plate surface. It is not certain why the results obtained using different aminocarboxylic acid/salt stabilizers vary. What is certain is that the polyacrylic acid thickener is more resistant to attack than many other thickeners and that the presence of an aminocarboxylic acid/salt stabilizer can enhance this stability many fold.

In addition, the stabilizer prevents substantial hydrogen peroxide decomposition at room temperature. Hydrogen peroxide loss in gels utilizing polyacrylic acid thickeners and aminocarboxylic acid/salt stabilizers is less than 0.05% by weight per day.

The end result is that the aqueous gels can now be produced that have commercially viable shelf-lives at room temperature. Thus, constant refrigeration, which is both expensive and inconvenient, is no longer necessary.

In addition to the aforementioned components, a neutralizing agent may be added to the aqueous gel. The presence of a neutralizing agent is preferred since it serves to further thicken the system. The neutralization agent ionizes the polyacrylic acid and generates negative charges along the backbone of the polymer. Repulsions of like charges then cause uncoiling of the polymer into an extended structure. This reaction is rapid and gives instantaneous thickening.

The inorganic and organic neutralizing agents which may be employed are bases. Suitable bases include alkali metal hydroxides and ammonium hydroxide, carbonates, alkoxides, oxides, peroxides, superoxides, and water soluble organic amines. Amino acids such as β-alanine and lysine can also be used for neutralization and viscosity modification. Preferred bases include sodium hydroxide, potassium hydroxide, ammonium hydroxide, triethanolamine (TEA), aminomethyl propanol (AMP), 2-amino-2-hydroxymethyl-1,3-propanediol (Tromethamine), tetrahydroxypropyl ethylenediamine, and tris(hydroxymethyl)aminomethane (TRIS). The amount of base utilized is the amount of base necessary to fully neutralize the polyacrylic acid thickener in the aqueous gel. This amount will vary considerably depending on the nature of the base and the amount of polyacrylic acid. In example, the following Table 1 sets forth the amount of different bases required to neutralize polyacrylic acid to an appropriate pH of 6.0-7.0:

TABLE 1
Relative
ratio of base to one part
Base polyacrylic acid by weight
Sodium hydroxide (18% solution) 0.5
Potassium hydroxide (18% solution) 0.5
Ammonium hydroxide (28% solution) 0.3
Triethanolamine (TEA) 2.0
Tromethamine (2-Amino-2-Hydroxymethyl- 2.0
1,3-propandiol)
Aminomethyl propanol (AMP) 1.5
Tetrahydroxypropyl ethylene diamine 2.0

The dental bleaching gel of the instant invention can be applied to the teeth in a number of ways. In example, the gel can be applied to the teeth using a brush, syringe, tray, or any other application means.

In a typical treatment process, the soft tissues surrounding the teeth are first covered with a protecting device, e.g. a ligated rubber dam. This is important because the more hydrogen peroxide a dental bleaching gel contains, the more likely it is to bum the soft tissue upon contact. Dental bleaching gels containing at least 30% by weight hydrogen peroxide will immediately bum any soft tissue they contact, quickly turning the tissue white.

Next a brush, needle, or some other delivery system is utilized to place the dental bleaching gel described above in contact with the teeth one wishes to bleach. Most patients only request treatment on the labial surfaces of the 6 to 8 front teeth which show most prominently when one smiles.

The dental bleaching gel is then allowed to remain in contact with the teeth for a period of time ranging anywhere from 5 minutes to one hour. Preferably, however, this contact period ranges from 20 to 30 minutes. As stated earlier, the bleaching effect of any dental bleaching gel is directly proportional to this residence time.

The bleaching effect of the hydrogen peroxide in a given period of time can be amplified by applying a heat lamp or laser light to the dental bleaching gel once it is in place on the teeth. The heat and light serve to increase the rate of bleaching of the hydrogen peroxide, providing a shorter period of time for whitening the teeth.

Once the treatment is done, the gel is removed with a gauze or some other means. The patient's mouth is then thoroughly cleaned with water and suction. When the dental bleaching gel comprises at least 20% by weight hydrogen peroxide, only one or two such treatments are necessary.

The following examples are illustrative of the invention:

EXAMPLES 1-19

Various blends of powdered stabilizer (or aqueous solution in the case of Versenol 120) and powdered thickening agent were weighed in a plastic or glass beaker. Aqueous hydrogen peroxide was then added to the blends in the amount of 35% (w/w). The mixtures were gently stirred until the powdered ingredients fully dissolved. This completed the procedure in the blends wherein carboxymethylcellulose, xanthan gum, and carrageenan were used as the thickeners. In the blends containing polyacrylic acid as the thickener, triethanolamine was also added. All of the gels were then packaged in 10 mL polyethylene syringes. The composition of each blend formulation is set forth in the following Table 2:

TABLE 2
Tri-
ethanol-
Gelling agent Stabilizer 35% H2O2 amine
Example (grams) (grams) (grams) (grams)
 1 0.102 20.00 0.050
Polyacrylic acid*1
 2 0.102 0.030 20.00 0.050
Polyacrylic acid CaNa2EDTA*5
 3 0.412 0.030 20.00
Xanthum Gum*2 CaNa2EDTA
 4 0.514 0.031 20.00
Xanthum Gum CaNa2EDTA
 5 0.612 0.030 20.00
Carboxymethyl CaNa2EDTA
cellulose*3
 6 1.262 0.030 20.00
Sodium CaNa2EDTA
carrageenan*4
 7 0.102 0.0294 20.00 0.150
Polyacrylic acid CDTA*6
 8 0.102 0.0310 20.00 0.100
Polyacrylic acid Na2EDTA
 9 0.102  .0309 20.00 0.100
Polyacrylic acid Na4EDTA
10 0.102 0.0972 20.00 0.100
Polyacrylic acid Na3HEDTA*7
11 0.102 0.10 20.00 0.100
Polyacrylic acid Vitamin E*8
and
0.030
CaNa2EDTA
12 0.1025 0.0312 20.0189 0.250
Polyacrylic acid Na3NTA*9
13 0.1021 0.0318 20.0366 0.200
Polyacrylic acid Na2NTA
14 0.1032 0.0309 20.0029 0.050
Polyacrylic acid NaCaHEDTA
15 0.1022 0.0370 20.0305 0.200
Polyacrylic acid NaCa2DTPA*10
16 0.1020 0.0300 20.0000 0.300
Polyacrylic acid NaCaNTA
17 0.1026 0.0311 20.0126 0.200
Polyacrylic acid Ca3TTHA*11
18 0.1019 0.0311 20.0339 0.100
Polyacrylic acid Na2Ca2TTHA
19 0.1024 0.0313 20.0032 0.100
Polyacrylic acid Na2CaGEDTA*12
*1Available from B.F. Goodrich and called Ultrez 10
*2Available from Aldrich
*3Available from Van Waters & Rogers, Inc.
*4Available from FMC Corporation
*5EDTA = Ethylenediamine tetraacetic acid
*6CDTA = trans-1,2-cyclohexylene dinitrilo tetraacetic acid
*7HEDTA = N-(2-hydroxyethyl)ethylenediamine triacetic acid which is available as Versenol 120 from Dow Chemical Corp.
*8Vitamin E = (DL-α-Tocopherol) and is available from Fluka Chemie
*9Nitrilotriacetic acid
*10DTPA = Diethylene triamine pentaacetic acid
*11TTHA = Triethylene tetramine hexaacetic acid
*12GEDTA = Ethyleneglycol bis (2-aminoethylether) tetraacetic acid

Gel stability was evaluated by placing a drop of each gel onto the surface of a flat glass plate. The plate was then tilted so that the flat surface was vertical. Gels were considered unsatisfactory when the gel droplet would not remain in place on the plate surface.

Hydrogen peroxide stability was evaluated by iodometric titration. For more information concerning this test see page 854 of “Quantitative Chemical Analysis,” 4th edition, 1969, written by I. M. Kolthoff, E. B. Sandell, E. J. Meehan and Stanley Bruckstein, and published by The Macmillan Company/Collier-Macmillan Limited in London, which is herein incorporated by reference. Peroxide concentrations as a function of time were fitted to a zero order kinetic model, and the zero order rate constant (% peroxide loss per day) was used to measure peroxide stability. The tendency of the gels to produce oxygen during storage was also observed. This was done in two ways. First, any displacement of the syringe plunger was noted during each sampling interval. Second, any gel that expelled from the syringe tip was also noted.

The results of these stability studies are set forth in the following Table 3, wherein each example corresponds to a like numbered example in Table 2:

TABLE 3
Days as a satisfactory k
Example gel (% H202 per day) Self-expelling
1 7 0.04 Yes
2 84 −0.004 No
3 28 0.0002 No
4 28 −0.01 No
5 7 −0.01 Yes
6 7 −0.05 No
7 48 −0.004 No
8 33 −0.05 Yes
9 57 −0.01 No
10 44 0.01 Yes
11 18 0.01 No
12 8 −0.001 ?
13 8 −0.01 ?
14 <5 −0.03 No
15 3 No
16 <3 Yes
17 <7 −0.01 No
18 <7 −0.02 No
19 <3 No

Examples 2-6 demonstrate the variations in stability that result from using different gelling agents with identical amounts of stabilizer (CaNa2EDTA) and identical amounts of hydrogen peroxide. As can be seen, the polyacrylic acid thickening agent Ultrez 10 is by far the best gelling agent from the standpoint of gel stability, although xanthan gum provides a gel with reasonably good stability. Carboxymethylcellulose and carageenan were not satisfactory. A comparison of Examples 1 and 2 demonstrates that the presence of the CaNa2EDTA stabilizer greatly enhances the gel stability provided by polyacrylic acid thickening agents.

Examples 7-19 demonstrate how the stability of gels utilizing polyacrylic acid gelling agents varies depending on the quantity and type of aminocarboxylic acid stabilizer employed. As can be seen, the best stabilizers are ETDA and its salts, CDTA, and HEDTA. These stabilizers form gels which have good gel stability, good hydrogen peroxide stability and a low tendency to produce oxygen gas. Note that some of the gels have positive zero order constants for hydrogen peroxide decomposition. This is thought to be due to a very low rate of hydrogen peroxide decomposition in combination with a much higher rate of water evaporation.

While the invention has been described in conjunction with the specific embodiments outlined above, it is evident that many alternatives, modifications, and variations will be apparent to those skilled in the art. Accordingly, the preferred embodiments of the invention are intended to be illustrative and not limiting. Various changes may be made without departing from the spirit and scope of the invention as defined in the claims.

Patent Citations
Cited PatentFiling datePublication dateApplicantTitle
US4226851Jul 11, 1979Oct 7, 1980Sompayrac Hewitt AStable dental composition containing hydrogen peroxide
US4812173May 1, 1987Mar 14, 1989Ciba-Geigy CorporationStabilized hydrogen peroxide contact lens disinfecting solution
US5084268Jun 17, 1991Jan 28, 1992Dental Concepts, Inc.Tooth whitening dentifrice
US5098303Jul 13, 1990Mar 24, 1992Ultradent Products, Inc.Method for bleaching teeth
US5165424Aug 9, 1990Nov 24, 1992Silverman Harvey NMethod and system for whitening teeth
US5248389Jul 13, 1992Sep 28, 1993Fmc CorporationProcess for peroxide bleaching of mechanical pulp using sodium carbonate and non-silicate chelating agents
US5290566Dec 18, 1990Mar 1, 1994Schow Robert STooth whitening formulation and method
US5326685Sep 14, 1992Jul 5, 1994Gaglio Thomas JViscous fluid dispensing apparatus
US5376006Sep 24, 1992Dec 27, 1994Ultradent Products, Inc.Dental bleaching compositions and methods for bleaching teeth surfaces
US5422073Dec 18, 1991Jun 6, 1995Allergan, Inc.Method and composition for disinfecting contact lenses
US5500186Mar 10, 1995Mar 19, 1996Allergan, Inc.Method and composition for disinfecting contact lenses
US5593637Jan 26, 1996Jan 14, 1997AllerganMethod and composition for disinfecting contact lenses
US5631000Mar 11, 1996May 20, 1997Laclede Professional Products, Inc.Anhydrous tooth whitening gel
US5641386Oct 26, 1994Jun 24, 1997Akzo Nobel NvAminoalkane diphosphonic acids in pulp bleaching
US5718886Dec 23, 1996Feb 17, 1998Laclede Professional Products, Inc.Stabilized anhydrous tooth whitening gel
US5725843Sep 27, 1996Mar 10, 1998Ultradent Products, Inc.Methods for bleaching teeth surfaces
US5756045Nov 22, 1996May 26, 1998AllerganMethod and composition for disinfecting contact lenses
US5759440Jun 7, 1995Jun 2, 1998Interox (Societe Anonyme)Stabilized aqueuous solution of hydrogen peroxide and process for stabilizing an aqueous solution of hydrogen peroxide
US5785527Jan 10, 1997Jul 28, 1998Ultradent Products, Inc.Stable light or heat activated dental bleaching compositions
US5851512May 30, 1997Dec 22, 1998Ultradent Products, Inc.Dental compositions having a sticky matrix material for treating sensitive teeth
US5858332Jan 10, 1997Jan 12, 1999Ultradent Products, Inc.Dental bleaching compositions with high concentrations of hydrogen peroxide
US5879691Jun 6, 1997Mar 9, 1999The Procter & Gamble CompanyDelivery system for a tooth whitener using a strip of material having low flexural stiffness
US5891453Mar 17, 1998Apr 6, 1999The Procter & Gamble CompanyDelivery system for a tooth whitener using a strip of material having low flexural stiffness
US5894017Jun 6, 1997Apr 13, 1999The Procter & Gamble CompanyDelivery system for an oral care substance using a strip of material having low flexural stiffness
US5922307Sep 25, 1996Jul 13, 1999R. Eric MontgomeryTooth bleaching compositions
US5985249Oct 14, 1997Nov 16, 1999Ultradent Products, Inc.Sticky dental compositions for adhering a passive-type dental tray over a person's teeth
US5989569Jun 6, 1997Nov 23, 1999The Procter & Gamble CompanyDelivery system for a tooth whitener using a permanently deformable strip of material
US6458340Nov 12, 1999Oct 1, 2002Den-Mat CorporationDesensitizing bleaching gel
Referenced by
Citing PatentFiling datePublication dateApplicantTitle
US7750106Jul 6, 2010Avon Products, Inc.Cosmetic compositions having in-situ hydrosilylation cross-linking
US8034323Oct 11, 2011Avon Products, Inc.Cosmetic compositions having in-situ silicone condensation cross-linking
US8574555Feb 1, 2007Nov 5, 2013Premier Dental Products CompanyStable one-part aqueous tooth whitening composition
US20070122361 *Nov 29, 2005May 31, 2007Weitao JiaTooth colorant and whitener, method of manufacture, and method of use thereof
US20070142575 *Dec 21, 2005Jun 21, 2007Tao ZhengCosmetic compositions having in-situ hydrosilylation cross-linking
US20070142599 *Dec 21, 2005Jun 21, 2007Tao ZhengCosmetic compositions having in-situ silicone condensation cross-linking
US20070202059 *Feb 1, 2007Aug 30, 2007Premier Dental Products CompanyStable one-part aqueous tooth whitening composition
US20080044796 *Aug 18, 2006Feb 21, 2008Beyond Technology Corp.A teeth whitening system and a method for whitening teeth
Classifications
U.S. Classification252/186.26, 433/215, 433/216, 124/53, 252/186.29
International ClassificationA61K8/22, A61K8/44, A61Q11/00, A61K8/81
Cooperative ClassificationA61Q11/00, A61K8/44, A61K8/8147, A61K8/22
European ClassificationA61K8/44, A61Q11/00, A61K8/22, A61K8/81K2
Legal Events
DateCodeEventDescription
May 5, 2004ASAssignment
Owner name: GILLETTE COMPANY, THE, MASSACHUSETTS
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:DEN-MAT CORPORATION;REEL/FRAME:014600/0615
Effective date: 20040429
Feb 27, 2006ASAssignment
Owner name: MCNEIL-PPC, INC., NEW JERSEY
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:THE GILLETTE COMPANY;REEL/FRAME:017215/0868
Effective date: 20051221
Apr 4, 2008FPAYFee payment
Year of fee payment: 4
May 2, 2012FPAYFee payment
Year of fee payment: 8
Jul 1, 2015ASAssignment
Owner name: JOHNSON & JOHNSON CONSUMER INC., NEW JERSEY
Free format text: MERGER AND CHANGE OF NAME;ASSIGNORS:MCNEIL-PPC, INC.;JOHNSON & JOHNSON CONSUMER INC.;REEL/FRAME:036042/0443
Effective date: 20150623