|Publication number||US6999559 B2|
|Application number||US 10/367,567|
|Publication date||Feb 14, 2006|
|Filing date||Feb 14, 2003|
|Priority date||Nov 10, 2000|
|Also published as||US6546080, US20030147501|
|Publication number||10367567, 367567, US 6999559 B2, US 6999559B2, US-B2-6999559, US6999559 B2, US6999559B2|
|Inventors||Kurt Alfred Edward Geitz|
|Original Assignee||Scimed Life Systems, Inc.|
|Export Citation||BiBTeX, EndNote, RefMan|
|Patent Citations (97), Referenced by (1), Classifications (6), Legal Events (2) |
|External Links: USPTO, USPTO Assignment, Espacenet|
Heat sink for miniature x-ray unit
US 6999559 B2
A heat exchanger removes heat generated by a miniaturized x-ray source to help remove heat at the site of x-ray generation.
1. An x-ray device comprising:
an x-ray source comprising an x-ray tube;
a metal collector for collecting heat energy released by the x-ray source; and
a heat exchanger operable inside a catheter, wherein said heat exchanger is from 1 to 15 millimeters thick, wherein said heat exchanger comprises a metal collector having a top face and a bottom face; a first metal layer adjacent the top face of said metal collector; and a second metal layer adjacent said first metal layer, the first and second metal layers having a channel formed therethrough for circulating a heat exchange fluid, the channel having an infeed end an exit end through which cooling fluid may enter and exit the channel;
wherein said heat exchanger is formed on said metal collector for absorbing and removing heat from said metal collector and is operable inside a catheter.
2. The x-ray device of claim 1, wherein said first metal layer comprises copper.
3. The x-ray device of claim 2, wherein said second metal layer comprises gold.
4. The x-ray device of claim 1, further comprising a pump connected to said channel for pumping said fluid through said channel.
5. The x-ray device of claim 1, wherein said metal collector comprises gold.
6. The x-ray device of claim 1, wherein at least one of said first layer and second layers comprises copper.
7. The x-ray device of claim 1, wherein at least one of said first layer and said second layer comprises gold.
This application is a divisional application of U.S. Ser. No. 09/709,668 filed Nov. 10, 2000, U.S. Pat. No. 6,546,080, incorporated herein by reference.
FIELD OF THE INVENTION
The invention relates to a heat sink for a miniaturized x-ray unit which channels away heat from the X-ray source during operation.
BACKGROUND AND SUMMARY OF THE INVENTION
Traditionally, x-rays have been used in the medical industry to view bone, tissue and teeth. X-rays have also been used to treat cancerous and precancerous conditions by exposing a patient to x-rays using an external x-ray source. Treatment of cancer with x-rays presents many well documented side effects, many of which are due to the broad exposure of the patient to the therapeutic x-rays.
Minimally invasive endoscopic techniques have been developed and are used to treat a variety of conditions. Endoluminal procedures are procedures performed with an endoscope, a tubular device into the lumen of which may be inserted a variety of rigid or flexible tools to treat or diagnose a patient's condition.
The desire for improved minimally invasive medical devices and techniques have led to the development of miniaturized x-ray devices that may be used in the treatment or prevention of a variety of medical conditions. International Publication No. WO 98/48899 discloses a miniature x-ray unit having an anode and cathode separated by a vacuum gap positioned inside a metal housing. The anode includes a base portion and a projecting portion. The x-ray unit is insulated and connected to a coaxial cable which, in turn, is connected to the power source. An x-ray window surrounds the projecting portion of the anode and the cathode so that the x-rays can exit the unit. The x-ray unit is sized for intra-vascular insertion, and may be used, inter alia, in vascular brachytherapy of coronary arteries, particularly after balloon angioplasty.
International Publication No. WO 97/07740 discloses an x-ray catheter having a catheter shaft with an x-ray unit attached to the distal end of the catheter shaft. The x-ray unit comprises an anode and a cathode coupled to an insulator to define a vacuum chamber. The x-ray unit is coupled to a voltage source via a coaxial cable. The x-ray unit can have a diameter of less than 4 mm and a length of less than about 15 mm, and can be used in conjunction with coronary angioplasty to prevent restenosis.
U.S. Pat. No. 5,151,100 describes a catheter device and method for heating tissue, the device having a catheter shaft constructed for insertion into a patient's body, and at least one chamber mounted on the catheter shaft. The catheter shaft has at least one lumen for fluid flow through the shaft. Walls that are at least in part expandable define the chambers. Fluid flows, through the lumens, between e chambers and a fluid source outside the body. The chambers can be filled with the fluid after they have been placed within the body. A heating device heats liquid within at least one of the chambers, so that heat is transmitted from the liquid to surrounding tissue by thermal conduction through the wall of the chamber. Means are provided for selectively directing heat transmission toward a selected portion of surrounding tissue. The chambers are fillable with fluid separately from each other, so that the chambers can occupy any of a plurality of possible total volumes. By selecting the total volume of chambers, compression of the tissue can be controlled, and hence the effectiveness of transfer of heat to the tissue can be controlled. According to the method, the catheter device is used to heat tissue from within a duct in a patient's body. The chambers are inserted into the duct and filled with fluid. Liquid is heated within at least one of the chambers, and heat is selectively directed toward a selected portion of surrounding tissue.
U.S. Pat. No. 5,542,928 describes a thermal ablation catheter includes an elongate body member having a heating element disposed over a predetermined length of its distal end or within an axial lumen. The heating element is suspended away from an exterior surface of the elongate member to form a circulation region thereunder. Alternatively, the heating element is distributed over some or all of the axial lumen. Thermally conductive fluid can be introduced through the lumen in the elongate member and ifito the circulation region to effect heat transfer. The catheter is used to introduce the thermally conductive medium to a hollow body organ where the heating element raises the temperature of the medium sufficiently to induce injury to the lining of the organ. Optionally, an expandable cage in the catheter or on an associated introducer sheath may be used in combination with a thermal ablation catheter. The expandable cage helps center the heating element on the catheter within the body organ and prevents direct contact between the heating element and the wall of the organ. When disposed on the catheter, the cage can be useful to position a flow directing element attached to the flow delivery lumen of the catheter. Heat transfer and temperature uniformity can be enhanced by inducing an oscillatory flow of the heat transfer medium through the catheter while heat is being applied.
U.S. Pat. No. 5,230,349 discloses a catheter having the active electrode is partially covered by a heat conducting and electrically insulating heat-sink layer for localizing and controlling an electrical heating of tissue and cooling of the active electrode by convective blood flow. The '349 patent also describes a current equalizing coating for gradual transition of electrical properties at a boundary of a metallic active electrode and an insulating catheter tube. The current equalizing coating controls current density and the distribution of tissue heating.
U.S. Pat. No. 4,860,744 discloses a system and method are disclosed for providing precisely controlled heating (and cooling) of a small region of body tissue to effectuate the removal of tumors and deposits, such as atheromatous plaque, without causing damage to healthy surrounding tissue, e.g. arterial walls. Such precisely controlled heating is produced through thermoelectric and resistive heating, and thermoelectric control of a heated probe tip. The system includes a probe tip with N-doped and P-doped legs of semiconductor material, a catheter to which the probe tip is attached for insertion into a patient's body, and a system control mechanism. The probe may be used for reduction and/or removal of atheromatous obstruction in arteries or veins. It may also be used for destruction of diseased tissue and/or tumors in various parts of the body, such as the brain or the bladder. The probe may be configured for either tip heating or for side heating.
U.S. Pat. No. 5,591,162 describes a catheter that provides precise temperature control for treating diseased tissue. The catheter may use a variety of passive heat pipe structures alone or in combination with feedback devices. The catheter is particularly useful for treating diseased tissue that cannot be removed by surgery, such as a brain tumor.
Miniaturized x-rays are not foolproof, however, and still present difficulties, because the x-ray unit generates heat which can damage adjacent tissue.
The present invention is a heat sink to be used with, e.g., an endoscopic x-ray device, to remove heat generated at the site of treatment, minimizing damage to surrounding tissues.
The device is sized to fit within the design constraints of miniaturized systems.
Other features of the present inventions will become readily apparent from the detailed description and drawings.
BRIEF DESCRIPTION OF THE DRAWINGS
The following detailed description, given by way of example, and not intended to limit the present invention solely thereto, will be best be understood in conjunction with the accompanying drawings:
FIG. 1 is an isometric view of a preferred heat exchanger according to the invention;
FIG. 2 is a miniaturized x-ray device according to the invention, showing the position of the heat exchanger;
FIGS. 3–8 shows the stepwise production of a heat exchanger from a multilayer substrate;
FIG. 9 is a detail of the flow channel within a heat exchanger of the invention, showing direction of flow; and
FIG. 10 is a top view of the heat exchanger through the center of the device, showing the path of the flow channel.
DETAILED DESCRIPTION OF THE INVENTION
The present invention relates to a heat exchanger preferably prepared using Very Large Scale Integration (VLSI) silicon processing. A heat exchanger substrate that is able to absorb the heat has thermal characteristics allowing the device to quickly absorb and transfer heat away from the site of heat generation, e.g., at an x-ray source. Copper is well suited for this function. The heat exchanger has a flow channel defined therein.
Construction and manufacture of the heat exchanger is shown in FIGS. 3–8. Referring to FIG. 3, copper layer 10 is plated adjacent a defined region of metal substrate, preferably gold, that is optionally coated or plated (9 a) with a metal such as gold or silver which is used as collector plate 9. The technique of plating or electroplating involves the immersion of the material to be added (e.g., copper) and the substrate in an electrolyte solution. Sputtering can also be used to coat collector 9 with a layer of metal which may be the same or different as the metal of collector 9. Current is forced to flow in the direction that causes ions to be attracted to the substrate. Plating is particularly useful in the formation of thick metal layers, such as copper.
Insulator 11 is deposited on the surface of the copper layer 10. Preferably, the insulator 11 is silicon dioxide. A photoresist 12 is then deposited on the insulator 11. Typically, the photoresist is an organic polymer that is sensitive to light or electron beams.
Photoresist 12 is selectively exposed to define a channel pattern using conventional optical (or imaging) techniques or electron beam machine to form imaged and non-imaged areas. Either of the imaged or non-imaged areas may define a series of interconnected channels 13 that form the fluid conduits as shown in FIG. 4.
Imaged or non-imaged regions of photoresist 12 are then removed and the portion that remains is used to mask insulator 11 from etching such as plasma, sputtering, and reactive ion etching (RIE) (FIG. 5). Plasma, sputtering, and RIE are variations on a general process in which gas is excited by RF or dc means and the excited ions remove the insulator 11 at the exposed regions, i.e, those not covered by photoresist 12. With sputter etching, the gas is inert and removes material mechanically. In plasma etching the gas is chemically active and removes material more or less isotropically as in chemical or wet etching. RIE is a sputtering which uses chemically active ions. The advantage of RIE is that electric fields cause the ions to impinge the surface vertically. This causes anisotropic etching with steep vertical walls needed for very fine linewidths.
The remaining photoresist 12 is then stripped or removed, e.g. by laser ablation or with a suitable solvent, as shown in FIG. 6, leaving insulating layer 11 with a series of interconnecting channels 13 therein.
A copper or other suitable metal layer 14 is then electroplated up and around the remaining insulator 11 as shown in FIG. 7, forming in essence, a continuous metal layer with layer 10 but having insulating portions 11 running therethrough. Special access holes (not shown), are used to etch away insulator selective to copper as shown in FIG. 8. Typically chemical or (wet) etching is used because of excellent selectivity. Selectivity refers to the propensity for the etching to etch the material one wants to remove rather than the material one does not want to remove. For example, if the insulator is silicon dioxide (SiO2), dilute hydrofluoric acid is the preferred etching agent. Removal of the insulator defines the conduit 15.
FIG. 9 (isometric view) and FIG. 10 (top down view) show the resultant channel in detail. The channels are defined in the substrate, and fluids circulate therein. The substrate is attached directly to the collector, which preferably formed as part of the x-ray tube.
As shown in FIG. 1 collector 1 with its fluid channels is manufactured as part of the x-ray tube that also contains the x-ray source 20. Conduits 21 for the fluids are made simultaneously with the channels of the heat exchanger. These conduits are an extension of the channels, and are made of copper and therefore can have the x-ray tube glass formed around them. The collector is shown as transparent in FIG. 1 so that the fluid channels can be seen. The collector 1 is located between x-ray source 20 and the substrate channels, as seen in FIG. 2.
The x-ray tube is inside a section of the catheter as seen in FIG. 2.
The heat itself will actively pump the fluid through the channel. However, for faster removal active pumps (not shown) can be used and are connected to the channels. The cooling fluid is preferably water or other high heat capacity fluid. Vacuum is great insulator in and of itself, so the lowest resistance path, i.e., the active heat exchange system will be followed. This heat exchanger system will carry most of the heat generated by the x-ray away from the site of x-ray generation.
The heat collectors of the invention preferably range from 1 to 15 mm in length and/or width. Preferably the heat sink is from 1 to 15 mm thick. The collector can be made of other material provided the materials have high heat transference capable of providing the desired result.
In the spirit of this invention, there could be “other means” for connecting a heat transfer system right on the collector inside the x-ray vacuum tube. For instance a Peltier Cooling System, or a radiation (heat fins) or convection system. These and other related ideas are considered within scope and spirit of this invention.
The heat exchanger of the invention can be used in any application where a miniaturized heat exchanger is required.
While the present invention has been particularly described with respect to the illustrated embodiment, it will be appreciated that various alterations, modifications and adaptations may be made on the present disclosure, and are intended to be within the scope of the present invention. It is intended that the appended claims be interpreted as including the embodiment discussed above, those various alternatives, which have been described, and all equivalents thereto.
All cited references are incorporated herein by reference.
|Cited Patent||Filing date||Publication date||Applicant||Title|
|US2740095||Dec 1, 1952||Mar 27, 1956||Ladish Co||Electrical conductor|
|US3248473||Sep 6, 1963||Apr 26, 1966||Int Standard Electric Corp||Low-capacitance type of high-frequency cable|
|US3541221||Dec 10, 1968||Nov 17, 1970||Comp Generale Electricite||Electric cable whose length does not vary as a function of temperature|
|US3811426||May 21, 1973||May 21, 1974||Atomic Energy Commission||Method and apparatus for the in-vessel radiation treatment of blood|
|US3906333||Sep 30, 1974||Sep 16, 1975||United Aircraft Corp||Low cost switching high voltage supply|
|US3992633 *||Dec 9, 1974||Nov 16, 1976||The Machlett Laboratories, Incorporated||Broad aperture X-ray generator|
|US4143275||Sep 28, 1977||Mar 6, 1979||Battelle Memorial Institute||Applying radiation|
|US4323736||Aug 11, 1980||Apr 6, 1982||Strickland James C||Step-up circuit for driving full-range-element electrostatic loudspeakers|
|US4459990||Jan 26, 1982||Jul 17, 1984||Elscint, Incorporated||Radiographic method and apparatus for the visualization of the interior of a body particularly useful for the visualization of a subject's circulatory system|
|US4500832||Feb 28, 1983||Feb 19, 1985||Codman & Shurtleff, Inc.||Electrical transformer|
|US4595843||May 7, 1984||Jun 17, 1986||Westinghouse Electric Corp.||Low core loss rotating flux transformer|
|US4599483||Oct 12, 1984||Jul 8, 1986||Audioplan Renate Kuhn||Signal cable|
|US4634126||Mar 26, 1985||Jan 6, 1987||Kabushiki Kaisha Universal||Device for converting the amount of a mechanical displacement into electrical signal|
|US4641649||Oct 30, 1985||Feb 10, 1987||Rca Corporation||Method and apparatus for high frequency catheter ablation|
|US4652846||Feb 19, 1986||Mar 24, 1987||Siemens Aktiengesellschaft||Small transformer with shield|
|US4810834||Nov 19, 1987||Mar 7, 1989||Alcatel N.V.||Tensionproof cable|
|US4858095||Oct 19, 1988||Aug 15, 1989||Kabushiki Kaisha Toshiba||Magnetron drive apparatus|
|US4860744||Nov 2, 1987||Aug 29, 1989||Raj K. Anand||Thermoelectrically controlled heat medical catheter|
|US4993404||Jun 26, 1989||Feb 19, 1991||Lane Timothy G||Fluoroscopy switching device|
|US5006119||May 25, 1989||Apr 9, 1991||Engineering & Research Associates, Inc.||Hollow core coaxial catheter|
|US5026367||Mar 18, 1988||Jun 25, 1991||Cardiovascular Laser Systems, Inc.||Laser angioplasty catheter and a method for use thereof|
|US5041107||Oct 6, 1989||Aug 20, 1991||Cardiac Pacemakers, Inc.||Electrically controllable, non-occluding, body implantable drug delivery system|
|US5043530||Jul 31, 1989||Aug 27, 1991||Champlain Cable Corporation||Electrical cable|
|US5084061||Aug 16, 1989||Jan 28, 1992||Gau Fred C||Intragastric balloon with improved valve locating means|
|US5090043 *||Nov 21, 1990||Feb 18, 1992||Parker Micro-Tubes, Inc.||X-ray micro-tube and method of use in radiation oncology|
|US5127394||Jun 22, 1990||Jul 7, 1992||Tilane Corporation||Fluoroscopy switching device|
|US5151100||Jul 3, 1990||Sep 29, 1992||Boston Scientific Corporation||Heating catheters|
|US5153900||Sep 5, 1990||Oct 6, 1992||Photoelectron Corporation||Miniaturized low power x-ray source|
|US5165093||Mar 23, 1992||Nov 17, 1992||The Titan Corporation||Interstitial X-ray needle|
|US5199939||Feb 23, 1990||Apr 6, 1993||Dake Michael D||Radioactive catheter|
|US5230349||Jun 4, 1992||Jul 27, 1993||Sensor Electronics, Inc.||Electrical heating catheter|
|US5246437||Apr 10, 1992||Sep 21, 1993||Abela George S||Cell treatment apparatus and method|
|US5253653||Oct 31, 1991||Oct 19, 1993||Boston Scientific Corp.||Fluoroscopically viewable guidewire for catheters|
|US5298682||Aug 20, 1992||Mar 29, 1994||Wireworld By David Salz, Inc.||Optimized symmetrical coaxial cable|
|US5341281||May 14, 1993||Aug 23, 1994||Allen-Bradley Company, Inc.||Harmonic compensator using low leakage reactance transformer|
|US5347255||Feb 17, 1993||Sep 13, 1994||Tdk Corporation||Variable inductance coil device|
|US5354220||Sep 30, 1993||Oct 11, 1994||Diagnostic Devices Group, Limited||Electrical coupler for coupling an ultrasonic transducer to a catheter|
|US5369679||Oct 2, 1992||Nov 29, 1994||Photoelectron Corporation||Low power x-ray source with implantable probe for treatment of brain tumors|
|US5372603||Mar 28, 1991||Dec 13, 1994||Engineering And Research Associates, Inc.||Hollow core coaxial catheter|
|US5379779||Aug 16, 1993||Jan 10, 1995||Boston Scientific Corporation||Zebra exchange guidewire|
|US5392020||Dec 14, 1992||Feb 21, 1995||Chang; Kern K. N.||Flexible transformer apparatus particularly adapted for high voltage operation|
|US5395362||Jan 14, 1992||Mar 7, 1995||Summit Technology||Methods and apparatus for distributing laser radiation|
|US5422926||Jan 21, 1994||Jun 6, 1995||Photoelectron Corporation||X-ray source with shaped radiation pattern|
|US5427115||Sep 13, 1993||Jun 27, 1995||Boston Scientific Corporation||Apparatus for stricture diagnosis and treatment|
|US5442678||Jan 21, 1994||Aug 15, 1995||Photoelectron Corporation||X-ray source with improved beam steering|
|US5503613||Jan 21, 1994||Apr 2, 1996||The Trustees Of Columbia University In The City Of New York||Apparatus and method to reduce restenosis after arterial intervention|
|US5528652||Aug 5, 1994||Jun 18, 1996||Photoelectron Corporation||Method for treating brain tumors|
|US5542928||Jun 27, 1994||Aug 6, 1996||Innerdyne, Inc.||Method and device for thermal ablation having improved heat transfer|
|US5562633||Sep 22, 1992||Oct 8, 1996||Sterimatic Holdings Limited||Catheter placement units|
|US5566221||Jul 12, 1994||Oct 15, 1996||Photoelectron Corporation||Apparatus for applying a predetermined x-radiation flux to an interior surface of a body cavity|
|US5578008||Oct 14, 1993||Nov 26, 1996||Japan Crescent, Inc.||Heated balloon catheter|
|US5578018||May 24, 1995||Nov 26, 1996||Boston Scientific Corporation||Apparatus for in situ measurement of stricture length for stent|
|US5591162||Mar 21, 1994||Jan 7, 1997||The Texas A&M University System||Treatment method using a micro heat pipe catheter|
|US5593524||Nov 14, 1994||Jan 14, 1997||Philips; Peter A.||Electrical cable reinforced with a longitudinally applied tape|
|US5599346||Aug 24, 1994||Feb 4, 1997||Zomed International, Inc.||RF treatment system|
|US5621780||Jul 27, 1995||Apr 15, 1997||Photoelectron Corporation||X-ray apparatus for applying a predetermined flux to an interior surface of a body cavity|
|US5651047||Feb 10, 1995||Jul 22, 1997||Cardiac Mariners, Incorporated||Maneuverable and locateable catheters|
|US5697428 *||Dec 2, 1994||Dec 16, 1997||Actronics Kabushiki Kaisha||Tunnel-plate type heat pipe|
|US5704914||Feb 23, 1996||Jan 6, 1998||Stocking; John E.||Catheter placement assembly|
|US5718688||Aug 18, 1995||Feb 17, 1998||Sterimatic Holdings Limited||Catheter placement units|
|US5720720||Mar 15, 1996||Feb 24, 1998||The United States Of America As Represented By The Department Of Health And Human Services||Convection-enhanced drug delivery|
|US5782740||Aug 29, 1996||Jul 21, 1998||Advanced Cardiovascular Systems, Inc.||Radiation dose delivery catheter with reinforcing mandrel|
|US5793272||Aug 23, 1996||Aug 11, 1998||International Business Machines Corporation||Integrated circuit toroidal inductor|
|US5795339||Oct 24, 1996||Aug 18, 1998||Becton Dickinson And Company||Catheter-advancement actuated needle retraction system|
|US5816999||Jul 24, 1997||Oct 6, 1998||Bischoff; Jeffrey||Flexible catheter for the delivery of ionizing radiation to the interior of a living body|
|US5865806||Apr 4, 1996||Feb 2, 1999||Becton Dickinson And Company||One step catheter advancement automatic needle retraction system|
|US5919172||Jul 17, 1996||Jul 6, 1999||Becton, Dickinson And Company||Hypodermic needle having a differential surface finish|
|US5997462||Jan 8, 1998||Dec 7, 1999||Delft Instruments Intellectual Property B.V.||Method and apparatus for treating a blood vessel lesion|
|US6061587||May 15, 1997||May 9, 2000||Regents Of The University Of Minnesota||Method and apparatus for use with MR imaging|
|US6066130||Oct 24, 1988||May 23, 2000||The General Hospital Corporation||Delivering laser energy|
|US6095966||Feb 20, 1998||Aug 1, 2000||Robert A. Ganz||X-ray device having a dilation structure for delivering localized radiation to an interior of a body|
|US6108402||Jan 16, 1998||Aug 22, 2000||Medtronic Ave, Inc.||Diamond vacuum housing for miniature x-ray device|
|US6111933||Jan 21, 1998||Aug 29, 2000||U.S. Philips Corporation||X-ray device including a piezoelectric transformer|
|US6135997||Nov 16, 1998||Oct 24, 2000||Vnus Medical Technologies, Inc.||Method for treating hemorrhoids|
|US6143018||May 11, 1994||Nov 7, 2000||Ceramoptec Gmbh||Method and device for thermally obliterating biological tissue|
|US6148061||Apr 28, 1998||Nov 14, 2000||Newton Scientific, Inc.||Miniature x-ray unit|
|US6171249||Oct 13, 1998||Jan 9, 2001||Circon Corporation||Ultrasound guided therapeutic and diagnostic device|
|US6183410||May 6, 1999||Feb 6, 2001||Precision Vascular Systems, Inc.||Radiation exposure device for blood vessels, body cavities and the like|
|US6190359||Oct 11, 1999||Feb 20, 2001||Medtronic, Inc.||Method and apparatus for drug infusion|
|US6217503||Sep 26, 1996||Apr 17, 2001||The Trustees Of Columbia University In The City Of New York||Apparatus and method to treat a disease process in a luminal structure|
|US6251060||Aug 17, 1999||Jun 26, 2001||Nucletron B.V.||Apparatus and method for temporarily inserting a radioactive source in an animal body|
|US6296603||May 26, 1998||Oct 2, 2001||Isostent, Inc.||Radioactive intraluminal endovascular prosthesis and method for the treatment of aneurysms|
|US6301328||Feb 11, 2000||Oct 9, 2001||Photoelectron Corporation||Apparatus for local radiation therapy|
|US6319188||Apr 26, 1999||Nov 20, 2001||Xoft Microtube, Inc.||Vascular X-ray probe|
|US6330481||Oct 4, 1999||Dec 11, 2001||Medtronic Inc.||Temporary medical electrical lead having biodegradable electrode mounting pad|
|US6364840||Sep 27, 2000||Apr 2, 2002||Boston Scientific Corporation||Acoustic imaging catheter and the like|
|US6375651||Feb 18, 2000||Apr 23, 2002||Scimed Life Systems, Inc.||Laser lithotripsy device with suction|
|US6551278||Nov 10, 2000||Apr 22, 2003||Scimed Life Systems, Inc.||Miniature x-ray catheter with retractable needles or suction means for positioning at a desired site|
|US6554757||Nov 10, 2000||Apr 29, 2003||Scimed Life Systems, Inc.||Multi-source x-ray catheter|
|US20010009970||Feb 12, 2001||Jul 26, 2001||Medtronic Ave, Inc.||X-ray catheter|
|US20010045387||May 16, 2001||Nov 29, 2001||Fuji Photo Film Co., Ltd.;||Plasma-or serum-collecting device|
|US20020003856||Feb 2, 2001||Jan 10, 2002||George Gutman||X-ray system with implantable needle for treatment of cancer|
|DE1904161A1||Jan 28, 1969||Oct 16, 1969||Iwatsu Electric Co Ltd||Elektrische Sonde|
|JPS63291309A|| ||Title not available|
|WO1997007740A1||Aug 22, 1996||Mar 6, 1997||Interventional Innovations Cor||X-ray catheter|
|WO1998048899A2||Apr 28, 1998||Nov 5, 1998||Newton Scient Inc||Miniature x-ray unit|
|WO2000009212A2||Aug 13, 1999||Feb 24, 2000||Dollimore Lucinda A||Apparatus and methods for radiotherapy|
|Citing Patent||Filing date||Publication date||Applicant||Title|
|US20090101308 *||Oct 22, 2007||Apr 23, 2009||The Peregrine Falcon Corporation||Micro-channel pulsating heat pump|
|Sep 27, 2013||REMI||Maintenance fee reminder mailed|
|Jun 22, 2009||FPAY||Fee payment|
Year of fee payment: 4