|Publication number||US7283862 B1|
|Application number||US 10/063,832|
|Publication date||Oct 16, 2007|
|Filing date||May 16, 2002|
|Priority date||May 16, 2002|
|Publication number||063832, 10063832, US 7283862 B1, US 7283862B1, US-B1-7283862, US7283862 B1, US7283862B1|
|Inventors||Glenn S. Slavin, Thomas K. F. Foo|
|Original Assignee||General Electric Company|
|Export Citation||BiBTeX, EndNote, RefMan|
|Patent Citations (10), Non-Patent Citations (2), Referenced by (11), Classifications (19), Legal Events (4)|
|External Links: USPTO, USPTO Assignment, Espacenet|
The present invention relates generally to magnetic resonance imaging (MRI), and more particularly to a method and apparatus to rapidly acquire multi-slice MR perfusion images having a large dynamic range particularly useful in capturing both renal functionality and angiographic data simultaneously.
When a substance such as human tissue is subjected to a uniform magnetic field (polarizing field B0), the individual magnetic moments of the spins in the tissue attempt to align with this polarizing field, but precess about it in random order at their characteristic Larmor frequency. If the substance, or tissue, is subjected to a magnetic field (excitation field B1) which is in the x-y plane and which is near the Larmor frequency, the net aligned moment, or “longitudinal magnetization”, MZ, may be rotated, or “tipped”, into the x-y plane to produce a net transverse magnetic moment Mt. A signal is emitted by the excited spins after the excitation signal B1 is terminated and this signal may be received and processed to form an image.
When utilizing these signals to produce images, magnetic field gradients (Gx Gy and Gz) are employed. Typically, the region to be imaged is scanned by a sequence of measurement cycles in which these gradients vary according to the particular localization method being used. The resulting set of received NMR signals are digitized and processed to reconstruct the image using one of many well known reconstruction techniques.
Visualization of blood flow into and out of the kidneys is indicative of renal function and perfusion. Having the capability to visualize the blood flow can be used to diagnose a broad range of diseases. In cases where compromised blood flow to the kidneys is suspected, perfusion imaging can be an important adjunct to magnetic resonance angiography (MRA) due to the uncertainties in the degree of stenosis as measured by MRA and its functional significance. Currently, most renal perfusion techniques are single slice acquisitions with relatively low temporal resolution. Such techniques require multiple breath-holds by the patient and therefore are time consuming and susceptible to blurring if the breath-holds are not held adequately. Further, although complete coverage of both kidneys is critical in ensuring visualization of local lesions, it is nearly impossible to do so with single slice techniques. That is, many single slice acquisitions may be reconstructed to form images of both kidneys, but such techniques are very time consuming and require multiple, exact-positioned patient breath-holds.
Contrast-enhanced MRI permits visualization of blood flow. However, rapid imaging is necessary to avoid motion artifacts. Further, the acquisition of multiple slices is required to visualize both kidneys, which often lie in different anatomical planes in their entirety. Therefore, a large dynamic range is necessary to see small changes in contrast uptake and to compensate for the relatively low signal-to-noise ratio caused by the preparatory saturation pulse and the rapid imaging acquisition.
Since MRI is the one modality that can provide morphologic, angiographic, and functional information in one session, it would be advantageous to acquire this information in a single scan. That is, since the degree of renal artery stenosis may not adequately reflect blood flow to certain organs, such as the kidneys, functional imaging is essential for renal evaluation.
It would therefore be desirable to have a method and apparatus that included a renal perfusion technique to allow rapid, high temporal resolution, multi-slice imaging of the kidneys that was not dependent upon ECG gating or periodic breath-holds. It would be additionally advantageous to have sufficiently large dynamic range to simultaneously include angiographic information of the renal arteries.
The present invention solves the aforementioned problems with the use of an interleaved acquisition in a non-ECG triggered scan resulting in multiple high-resolution images of the kidneys. The image data is acquired in rapid succession and can be performed with or without breath-holding. That is, the present technique allows renal perfusion analysis by rapidly acquiring high temporal resolution multi-slice images of the kidneys with sufficient spatial resolution to provide simultaneous angiographic information. The rapid acquisition of contiguous slices eliminates the need for breath-holding and minimizes slice misregistration. Furthermore, in accordance with the present invention, complete imaging coverage of the kidneys can be accomplished in approximately three seconds. Accordingly, the present invention provides an MR technique that allows evaluation of renal function by rapidly acquiring quantitative, high temporal resolution, multi-slice profusion images of the kidneys, while additionally providing sufficient spatial resolution to provide simultaneous angiographic information of the renal arteries.
A method of acquiring MR images is disclosed that includes applying an ungated pulse sequence and acquiring MR data in rapid succession of a selected anatomy. The method includes providing an intentional delay interval and then repeating the pulse sequence to acquire the ungated, multi-slice images with large dynamic range.
A pulse sequence is disclosed for profusion imaging that includes an interleaved preparation/acquisition sequence. This interleaved sequence has a number of preparation pulses and acquisition slices wherein each preparation pulse corresponds to a given acquisition slice and is timed to occur such that at least one other preparation pulse and one other acquisition slice occur between the corresponding pulse and slice. The interleaved sequence is then followed by a dead space to provide delay time sufficient to allow patient free-breathing. The repetition time is defined as the time of the interleaved preparation/acquisition sequence followed by the dead space. Each scanning session is defined by a prescribed number of times the pulse sequence of the repetition time is played out.
In accordance with another aspect of the invention, an MRI apparatus is disclosed to acquire multiple MR images having high resolution and increased spatial resolution that includes an MRI system having a plurality of gradient coils positioned about a bore of a magnet to impress a polarizing magnetic field. An RF transceiver system and an RF switch are controlled by a pulse module to transmit and receive RF signals to and from an RF coil assembly to acquire MR images. The MRI apparatus also includes a computer programmed to apply a pulse sequence that interleaves a given preparation pulse and acquisition slice combination with a preparation pulse and acquisition slice for another preparation pulse and acquisition slice combination. The pulse sequence is played out in rapid succession and is followed by a user prescribed delay time before it is repeated a prescribed number of times. A series of multiple high-resolution images is then reconstructed to provide the high temporal resolution and increase spatial resolution images sufficient to evaluate renal function and profusion.
In accordance with another aspect of the invention, the invention is embodied in a computer program stored on a computer readable storage medium and having instructions which, when executed by a computer, cause the computer to receive a user prescription defining selection of an interleaved pulse sequence, and in response thereto, receive at least a user prescribed delay time defining a period of time between application of the interleaved pulse sequence, an imaging plane, and a desired number of slices to be acquired with each pulse sequence application. The computer is also caused to apply the interleaved pulse sequence such that each preparation pulse is immediately followed by an acquisition slice with no delay time therebetween. A series of high resolution images is then acquired in rapid succession.
In accordance with another aspect of the invention, a method of analyzing renal function with functional MRA imaging includes injecting a contrast agent in a patient, defining an area of interest to include both kidneys of the patient, and applying an interleaved acquisition pulse sequence to the area of interest. The method also includes acquiring a series of high resolution images of the area of interest in rapid succession and then allowing a delayed relaxation time. The application of the interleaved acquisition pulse sequence is repeated along with the step of acquiring a series of high resolution images followed by a delayed relaxation time, a prescribed number of times. The method lastly includes evaluating the series of images that depict temporal phases of the contrast-enhanced blood uptake of both kidneys.
Various other features, objects and advantages of the present invention will be made apparent from the following detailed description and the drawings.
The drawings illustrate one preferred embodiment presently contemplated for carrying out the invention.
In the drawings:
The system control 32 includes a set of modules connected together by a backplane 32 a. These include a CPU module 36 and a pulse generator module 38 which connects to the operator console 12 through a serial link 40. It is through link 40 that the system control 32 receives commands from the operator to indicate the scan sequence that is to be performed. The pulse generator module 38 operates the system components to carry out the desired scan sequence and produces data which indicates the timing, strength and shape of the RF pulses produced, and the timing and length of the data acquisition window. The pulse generator module 38 connects to a set of gradient amplifiers 42, to indicate the timing and shape of the gradient pulses that are produced during the scan. The pulse generator module 38 can also receive patient data from a physiological acquisition controller 44 that receives signals from a number of different sensors connected to the patient, such as ECG signals from electrodes attached to the patient. And finally, the pulse generator module 38 connects to a scan room interface circuit 46 which receives signals from various sensors associated with the condition of the patient and the magnet system. It is also through the scan room interface circuit 46 that a patient positioning system 48 receives commands to move the patient to the desired position for the scan.
The gradient waveforms produced by the pulse generator module 38 are applied to the gradient amplifier system 42 having Gx, Gy, and Gz amplifiers. Each gradient amplifier excites a corresponding physical gradient coil in a gradient coil assembly generally designated 50 to produce the magnetic field gradients used for spatially encoding acquired signals. The gradient coil assembly 50 forms part of a magnet assembly 52 which includes a polarizing magnet 54 and a whole-body RF coil 56. A transceiver module 58 in the system control 32 produces pulses which are amplified by an RF amplifier 60 and coupled to the RF coil 56 by a transmit/receive switch 62. The resulting signals emitted by the excited nuclei in the patient may be sensed by the same RF coil 56 and coupled through the transmit/receive switch 62 to a preamplifier 64. The amplified MR signals are demodulated, filtered, and digitized in the receiver section of the transceiver 58. The transmit/receive switch 62 is controlled by a signal from the pulse generator module 38 to electrically connect the RF amplifier 60 to the coil 56 during the transmit mode and to connect the preamplifier 64 to the coil 56 during the receive mode. The transmit/receive switch 62 can also enable a separate RF coil (for example, a surface coil) to be used in either the transmit or receive mode.
The MR signals picked up by the RF coil 56 are digitized by the transceiver module 58 and transferred to a memory module 66 in the system control 32. A scan is complete when an array of raw k-space data has been acquired in the memory module 66. This raw k-space data is rearranged into separate k-space data arrays for each image to be reconstructed, and each of these is input to an array processor 68 which operates to Fourier transform the data into an array of image data. This image data is conveyed through the serial link 34 to the computer system 20 where it is stored in memory, such as disk storage 28. In response to commands received from the operator console 12, this image data may be archived in long term storage, such as on the tape drive 30, or it may be further processed by the image processor 22 and conveyed to the operator console 12 and presented on the display 16.
The present invention includes a method and system suitable for use with the above-referenced NMR system, or any similar equivalent system for obtaining MR images. The invention is directed toward obtaining contrast-enhanced MR renal perfusion imaging using an ungated, multi-slice, rapid acquisition with a large enough dynamic range to include multiple anatomic organs and a clinical application/process thereof. In a preferred embodiment, this technique offers a new application for renal perfusion with MR imaging. Because the invention includes repeated magnetization-preparation-acquisition of numerous sections of the kidneys in a very short time, the acquisition portions of the scan can be performed regardless of any required breath-holding. That is, while this technique can be performed with breath-holding, it is not necessary and therefore has a broader range of application. This technique provides image contrast and flexibility of prescription not previously available.
The present invention employs a technique in which an interleaved acquisition pulse sequence is played out to acquire images during a scanning session without the need of an ECG trigger. Referring to
The interleaved preparation/acquisition sequence 102, 104 is played out in rapid succession a given number of times to acquire multiple slices in different planes of the anatomy of interest. A delay time 110 is provided between each interleaved preparation/acquisition sequence 102, 104, etc. and includes dead space that can be used to allow patient free breathing before the occurrence of a next interleaved preparation/acquisition sequence. Preferably, the dead space 110 has a predefined delay time set by the operator that can be timed according to each patient's breathing cycle. In this manner, a series of high resolution images can be acquired in rapid succession of the area of interest. A steady state preparation sequence 112 is preferably played out before the next interleaved preparation/acquisition sequence 104. The steady state preparation sequence is used to ensure the appropriate state of magnetization for the next preparation/acquisition sequence. TIn represents the recovery time between the preparation and acquisition of slice n. The repeat time 114 is the time for one complete cycle and is repeated a prescribed number of times, as desired by the physician or clinician.
The present invention can employ either a conventional slice-selective RF pulse or a specially-selective RF pulse for the preparation sequence. An example of such a specially-selective RF pulse is shown with reference to
The present invention contemplates interleaving of the pre-saturation RF pulses, while providing saturation of blood over a large volume outside of a slice thickness defined by the size of the stop-band 124. Since each given slice is prepared before the acquisition of the preceding slice, the first slice in the sequence represents a special case. The first slice of the first phase has no preparation. In the example
In the preparation scheme shown in
In one preferred embodiment, the width of notch 124 is a user selectable parameter, which may be input through input device 13,
Accordingly, the present invention includes a clinical process of analyzing renal function with functional MR imaging that includes injecting a contrast agent in a patient, defining an area of interest to include a plane having both kidneys therein, applying an interleaved acquisition pulse sequence to the area of interest, and acquiring a series of high resolution images of the area of interest in rapid succession. This technique also includes providing a delayed relaxation time and then repeating the aforementioned steps a prescribed number of times. The method accordingly includes evaluating the series of images depicting temporal phases of contrast-enhanced blood uptake of both kidneys.
Contrast-enhanced perfusion imaging can be performed using ungated multi-shot echo-planar imaging during free breathing. Magnetization preparation is achieved using interleaved saturation recovery, as previously described. In a preferred embodiment, there is no dead space between slices, as the magnetization recovery time TI for a given slice is simultaneous with the acquisition of the previous slice. The maximum temporal resolution, defined as the time between consecutive acquisitions at the same slice location, equals NS×TI, where NS is the number of imaged slices acquired. Lower temporal resolution can also be achieved, allowing even shorter repeated breath-holds.
Actual perfusion MR imaging was conducted using a 1.5 T Signa CV/i scanner from GE Medical Systems, Milwaukee, Wis. Parameters included forty mT/m peak gradients and 150 T/m/s maximum slue rate. Other imaging parameters were: echotrain length (ETL 4); TI 272 msec; TR 8.8 Msec; TE 1.4 msec; 224×160 matrix; 25° flip angle; 40×30 cm field-of-view; contiguous 7 mm slices; 250 kHz bandwidth; 0.025 mmol/kg gadodiamide. Temporal resolution, which depended on the number of acquired slices, was 2-3 sec for coverage of both kidneys. Total scan time, which depended on the number of desired phases, was typically 2 to 4 minutes.
Quantitative image analysis can be performed that include operations for independent motion registration of both kidneys, surface coil intensity correction, and generation of enhancement curves.
As will now be apparent, the present invention demonstrates a free breathing, multi-slice renal perfusion technique that offers complete coverage of both kidneys with high temporal resolution and improved contrast enhancement using a very low contrast dose. With this technique, a single scan can provide a comprehensive evaluation of renal function.
Accordingly, the present invention includes a method of acquiring MR images that includes applying an ungated pulse sequence and acquiring MR data in rapid succession of a selected anatomy, providing a delay interval, and then repeating the application of the pulse sequence and delay interval a prescribed number of times. The method has enough dynamic range to thereby acquire MR image data of a second selected anatomy simultaneously with the first selected anatomy. In the aforementioned example, the first selected anatomy are kidneys of the patient and the invention further includes further reconstructing MR data images acquired in a series that depict temporal phases of contrast-enhanced blood uptake for renal function and perfusion evaluation. The second selected anatomy can therefore be a cardiac region of the patient to acquire angiographic information as well. Preferably, an interleaved saturation recovery sequence for magnetization preparation is applied before each pulse sequence is played out.
The invention also includes a pulse sequence for perfusion imaging of an anatomy of interest that includes an interleaved preparation acquisition sequence having a number of preparation pulses and a number of acquisition slices. Each preparation pulse corresponds to a given acquisition slice and is timed to occur such that at least one other preparation pulse and one other acquisition slice occur therebetween. A dead space is provided to allow a delay time sufficient to allow patient free breathing and magnetization equalization. A repetition time defines a time of the interleaved preparation/acquisition sequence followed by the dead space. A scanning session defines a prescribed number of times the pulse sequence and the repetition time is repeated. Additionally, a steady state preparation sequence can occur after each interleaved preparation acquisition sequence and preferably, immediately before a next interleave preparation/acquisition sequence. The pulse sequence is played out without any ECG trigger and acquires a series of multiple high resolution images in rapid succession. The dead space is preferably a user prescribed delay interval to allow magnetization equilibrium and free-breathing.
The invention also includes an MRI apparatus to acquire MR images having high temporal resolution and increased spatial resolution that includes a magnetic resonance imaging system having a plurality of gradient coils positioned about a bore of a magnet to impress a polarizing magnetic field and an RF transceiver system and an RF switch controlled by a pulse module to transmit RF signals to an RF coil assembly to acquire MR images. The MRI apparatus also includes a computer program to apply a pulse sequence that interleaves a given preparation pulse and acquisition slice combination with a preparation pulse and acquisition slice for different preparation pulse and acquisition slice combinations. The preparation pulses and acquisition slices are played out in rapid succession a given number of times, followed by a user prescribed delay time before repeating the entire pulse sequence a prescribed number of times. A series of multiple high resolution images can therefore be reconstructed.
The invention additionally includes a computer readable storage medium having stored thereon a computer program comprising instructions which, when executed by a computer, causes the computer receive a user prescription that defines selection of an interleaved pulse sequence. In response thereto, the computer receives at least a user prescribed delay time defining a time period between application of the interleaved pulse sequence, an imaging plane, and a desired number of slices to be acquired with each pulse sequence application. The interleaved pulse sequence is applied such that each preparation pulse is immediately followed by an acquisition slice with no delay time therebetween. A series of high resolution images is then acquired in rapid succession.
A method of analyzing renal function with functional MR imaging is incorporated herein that includes injecting a contrast agent in the patient, defining an area of interest to include both kidneys of the patient, and applying an interleaved acquisition pulse sequence to the area of interest. The method also includes acquiring a series of high resolution images of the area of interest in rapid succession, allowing a delayed relaxation time, and repeating the aforementioned steps a prescribed number of times. This method concludes with evaluating the series of images depicting temporal phases of contrast-enhanced blood uptake of both kidneys.
The present invention has been described in terms of the preferred embodiment, and it is recognized that equivalents, alternatives, and modifications, aside from those expressly stated, are possible and within the scope of the appending claims.
|Cited Patent||Filing date||Publication date||Applicant||Title|
|US5245282 *||Jun 28, 1991||Sep 14, 1993||University Of Virginia Alumni Patents Foundation||Three-dimensional magnetic resonance imaging|
|US5311132 *||Jul 28, 1992||May 10, 1994||The Board Of Trustees Of The Leland Stanford Junior University||Method of enhancing the focus of magnetic resonance images|
|US5320099 *||Aug 7, 1992||Jun 14, 1994||Trustees Of The University Of Penna.||MR angiography using steady-state transport-induced adiabatic fast passage|
|US5406203 *||Aug 10, 1992||Apr 11, 1995||The Trustees Of Columbia University In The City Of New York||Methods of multislice acquisition for magnetic resonance imaging|
|US5590654 *||Dec 28, 1995||Jan 7, 1997||Prince; Martin R.||Method and apparatus for magnetic resonance imaging of arteries using a magnetic resonance contrast agent|
|US6078175||Oct 26, 1998||Jun 20, 2000||General Electric Company||Acquistion of segmented cardiac gated MRI perfusion images|
|US6370415 *||Apr 10, 1998||Apr 9, 2002||Medi-Physics Inc.||Magnetic resonance imaging method|
|US6618605 *||Sep 8, 1999||Sep 9, 2003||General Electric Company||Method and apparatus for MR perfusion image acquisition using a notched RF saturation pulse|
|US20020077538 *||Dec 19, 2000||Jun 20, 2002||Manojkumar Saranathan||Acquisition of high-temporal free-breathing MR images|
|US20030199750 *||Apr 17, 2002||Oct 23, 2003||The Board Of Trustees Of The Leland Stanford Junior University||Rapid measurement of time-averaged blood flow using ungated spiral phase-contrast MRI|
|1||Slavin, Glenn S., et al., First-Pass Myocardial Perfusion MR Imaging with Interleaved Notched Saturation; Feasibility Study, Radiology 2001, 219:258-263.|
|2||Slavin, Glenn S., et al., Rapid Multi-Slice Renal Perfusion MR Imaging with Simultaneous Angiographic Screening, date unavailable.|
|Citing Patent||Filing date||Publication date||Applicant||Title|
|US7642776 *||Sep 27, 2007||Jan 5, 2010||Siemens Aktiengesellschaft||Method to determine an acquisition sequence in an imaging method for generation of 2D slice images|
|US8744551 *||Jul 12, 2012||Jun 3, 2014||Northshore University Healthsystem||Method for non-contrast enhanced magnetic resonance angiography|
|US9009016||Oct 15, 2012||Apr 14, 2015||Universitaetsklinikum Freiburg||NMR measurement of contrast medium concentrations|
|US9013184 *||Jan 26, 2012||Apr 21, 2015||Siemens Medical Solutions Usa, Inc.||MR imaging system for automatically providing incidental findings|
|US20130021030 *||Jan 26, 2012||Jan 24, 2013||Siemens Medical Solutions Usa, Inc.||MR Imaging System for Automatically Providing Incidental Findings|
|US20140294734 *||Nov 20, 2013||Oct 2, 2014||Case Western Reserve University||Magnetic Resonance Imaging (MRI) Based Quantitative Kidney Perfusion Analysis|
|CN102028466A *||Mar 31, 2010||Apr 27, 2011||东芝医疗系统株式会社||Magnetic resonance imaging apparatus|
|CN102028466B||Mar 31, 2010||Jun 19, 2013||株式会社东芝||Magnetic resonance imaging apparatus|
|CN102156270A *||Mar 7, 2011||Aug 17, 2011||上海卡勒幅磁共振技术有限公司||Method for correcting magnetic field gradient delay of magnetic resonance imaging system|
|DE102011084867A1 *||Oct 20, 2011||Apr 25, 2013||Universitätsklinikum Freiburg||NMR-Messung von Kontrastmittel-Konzentrationen|
|DE102011084867B4 *||Oct 20, 2011||Jul 24, 2014||Universitätsklinikum Freiburg||MRI-Verfahren und Tomographieeinrichtung zur quantitativen Messung der cerebralen Perfusion|
|U.S. Classification||600/420, 600/410, 324/309, 324/308, 600/407, 324/307, 324/306|
|Cooperative Classification||G01R33/5635, G01R33/563, G01R33/56366, G01R33/4838, G01R33/5601, G01R33/4835|
|European Classification||G01R33/483C, G01R33/483B1, G01R33/563K, G01R33/563P, G01R33/563|
|Jul 31, 2002||AS||Assignment|
Owner name: GE MEDICAL SYSTEMS GLOBAL TECHNOLOGY CO. LLC, WISC
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:SLAVIN, GLENN S.;FOO, THOMAS K.F.;REEL/FRAME:012941/0866
Effective date: 20020726
|Apr 20, 2004||AS||Assignment|
Owner name: GENERAL ELECTRIC COMPANY, NEW YORK
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:GE MEDICAL SYSTEMS GLOBAL TECHNOLOGY COMPANY, LLC;REEL/FRAME:016212/0534
Effective date: 20030331
|Apr 18, 2011||FPAY||Fee payment|
Year of fee payment: 4
|Apr 16, 2015||FPAY||Fee payment|
Year of fee payment: 8