|Publication number||US7306420 B2|
|Application number||US 10/389,383|
|Publication date||Dec 11, 2007|
|Filing date||Mar 14, 2003|
|Priority date||Mar 26, 2002|
|Also published as||CA2422664A1, CA2422664C, DE60300334D1, DE60300334T2, EP1348631A1, EP1348631B1, US20030185732|
|Publication number||10389383, 389383, US 7306420 B2, US 7306420B2, US-B2-7306420, US7306420 B2, US7306420B2|
|Inventors||Sergi Roura Adell, Jose Ramon Sanchez Sabate, Victor Grifols Lucas|
|Original Assignee||Probitas Pharma S.A.|
|Export Citation||BiBTeX, EndNote, RefMan|
|Patent Citations (4), Referenced by (3), Classifications (12), Legal Events (8)|
|External Links: USPTO, USPTO Assignment, Espacenet|
The present invention is intended to disclose a method and its apparatus for emptying blood plasma containers, which is applicable to the handling of containers of plasma in pharmaceutical laboratories, contributing significant characteristics of novelty and of inventive activity to its operation.
As is known, the handling of human plasma in laboratories specializing in pharmaceutical products related to blood plasma is based on using bottles which contain the plasma collected from donors, and which arrive at the laboratory frozen in order to preserve them, and carrying out the operations necessary for the utilisation of the product for pharmaceutical applications.
At present, the handling of the containers is carried out by semi-manual methods, with which it is not possible to guarantee optimum utilisation of the plasma from each of the bottles. It constitutes an important problem, especially from the point of view of costs, since in view of the high price of human plasma, imperfect emptying of the bottles, wasting a certain percentage of the product, represents a significant cost factor. Moreover, the procedure of defrosting and emptying the plasma affects the yield of the proteins which will subsequently be obtained in the fractionating process.
The present invention is intended to disclose a method and apparatus for achieving the automatic emptying of the bottles of plasma with a high yield, permitting substantially complete emptying thereof, that is to say, full utilisation of their contents.
According to the present invention, the bottles are subjected to a continuous process, part of which is performed outside the partition dividing the clean or aseptic room, in which the emptying of the bottles takes place, from the adjacent room for loading same, passing to a step of washing by means of hot, de-ionised water, afterwards passing to a rinsing step, likewise with de-ionised water, sprayed by means of nozzles, the water being recovered in the washing tank, after which follows a stage of drying by spraying with clean air drawn from the same room via a high-pressure fan and spray nozzles, after which there is a gripping and cutting step in which the top of the bottle is removed automatically, being collected in a suitable hopper, and finally emptying takes place by gravity with the assistance of compressed air to facilitate the discharge and internal drying of the bottles.
In order to carry out the method, the present invention provides for the production of a single installation in the form of a tunnel with a conveyor belt which starts in the entry section outside the clean or aseptic enclosure in which is located the remainder of the apparatus, which has a first washing zone equipped with spray nozzles for spraying hot, de-ionised water recirculated from a suction tank by means of a pump, and with the aid of a heat exchanger, in order to reach the bottle washing temperature. After the washing section, the conveyor belt transports the bottles in batches of the same number as a unitary group to the rinsing zone in which there are nozzles for spraying de-ionised water, the installation then comprising a drying zone to which the bottles are transported by the same belt and in which clean air drawn from the room through the high-pressure fan is blown by means of suitable nozzles. The installation continues with a pressing device by means of a counter-mould form which grips the unitary group of bottles, for example three bottles, by means of compressed air, having individual blade devices, preferably actuated by pneumatic cylinder and piston assemblies, for transverse cutting of the top of the bottle, after which the same installation has fibreoptic sensors for detecting the presence of the bottles, the zone including a robot which has a special part for simultaneously picking up the bottles which make up the unitary group which was previously subjected to washing, rinsing and de-frosting, effecting the emptying of the bottles and their subsequent discharge to a hopper for collecting the empty bottles.
For the sake of greater understanding, some drawings showing a complete installation for the implementation of the present invention are appended by way of non-limiting explanatory example.
The machine is made up in the form of a single assembly consisting principally of a tunnel in which is arranged a bottle-washing section 1, which continues in a rinsing section 2, and a drying section 3, following which there is the cutting press 4 for the bottles. The machine has an entry zone 5 for the introduction of the bottles into the process and a discharge zone 6 in which the discharge of the partially defrosted plasma and the discharge of the bottles take place.
The entry section 5 is located outside the enclosure termed clean or aseptic, which is separated off by the partition shown diagrammatically by the number 7.
In the entry zone 5, a conveyor belt 8 receives the bottles 9 in the planned number, for example, in groups of three bottles, by manual placement, passing then to the bottle washing zone 1, in which the bottles are washed by means of de-ionised hot water which is recirculated from a tank from which it is drawn by means of a pump, these not having been shown. Heating may be carried out by means of any type of heat exchanger, for example a steam heat exchanger, until the desired specified temperature is reached.
From the washing zone 1 the bottles pass, in unitary groups of the same number as put in place at the start, to the rinsing zone, in which they are subjected to the action of hot, de-ionised water in a similar manner to the washing water, by means of spray jets, the water being recovered in the washing tank and the surplus being eliminated by an overflow. Into the drying zone 3 is blown clean air, drawn from the same room through a high-pressure fan connected to nozzles, for example two nozzles, passing after drying to the cutting zone 4, in which the bottles are gripped and the transverse cutting of the rearward part is carried out by means of blades actuated by pneumatic cylinders or the like, the cut portions being collected in a hopper. The conveyor belt transports the cut units to the discharge zone, in which a robot 10 picks up the unitary group of bottles by means of a multiple gripping means 11 which moves them to the emptying point, indicated at the front of the machine in
As will be observed, the purpose of the machine of the present invention is that of handling the bottles of plasma until the masses of half-frozen plasma are emptied into a collecting hopper, from which it will pass to the melting zone, which does not form part of the machine.
One of the essential advantages derived from the present invention is that there is no human handling of the blood plasma, so that the risk of contamination conventionally involved in said handling is avoided.
|Cited Patent||Filing date||Publication date||Applicant||Title|
|US3420392 *||Feb 1, 1966||Jan 7, 1969||Fmc Corp||Tray filling and handling system|
|US4340152 *||Aug 8, 1980||Jul 20, 1982||Baxter Travenol Laboratories, Inc.||Method and apparatus for removing the contents of flexible or collapsible containers|
|US4994021 *||Nov 15, 1988||Feb 19, 1991||Baxter International Inc.||Apparatus and method for collecting and freezing blood plasma|
|US5829634 *||Apr 14, 1997||Nov 3, 1998||Immuno Aktiengesellschaft||Method of discharging a frozen blood product|
|Citing Patent||Filing date||Publication date||Applicant||Title|
|US7594790 *||May 5, 2006||Sep 29, 2009||Alcon, Inc.||System and method for pooling small volumes of liquid|
|US8690011 *||Jul 18, 2012||Apr 8, 2014||Grifols, S.A.||Device for emptying a blood product bag|
|US20130019993 *||Jul 18, 2012||Jan 24, 2013||Grifols, S.A.||Device for emptying a blood product bag|
|International Classification||A61G12/00, B65G65/23, B65B55/24, A61J1/14, B65B69/00, B08B3/08, B08B3/02|
|Cooperative Classification||B65B69/00, B65B55/24|
|European Classification||B65B55/24, B65B69/00|
|Mar 14, 2003||AS||Assignment|
Owner name: PROBITAS PHARMA S.A., SPAIN
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:ADELL, SERGI R.;SABATE, JOSE R.;LUCAS, VICTOR GRIFOLS;REEL/FRAME:013886/0887
Effective date: 20030109
|Dec 6, 2005||AS||Assignment|
Owner name: GRIFOLS, S.A., SPAIN
Free format text: CHANGE OF NAME;ASSIGNOR:PROBITAS PHARMA, S.A.;REEL/FRAME:017089/0345
Effective date: 20050722
|May 27, 2008||CC||Certificate of correction|
|Jan 4, 2010||AS||Assignment|
Owner name: GRIFOLS, S.A., SPAIN
Free format text: CHANGE OF ADDRESS;ASSIGNOR:GRIFOLS, S.A.;REEL/FRAME:023720/0951
Effective date: 20091218
|Feb 9, 2011||FPAY||Fee payment|
Year of fee payment: 4
|Jun 3, 2011||AS||Assignment|
Owner name: DEUTSCHE BANK AG NEW YORK BRANCH, NEW YORK
Free format text: SECURITY AGREEMENT;ASSIGNORS:GRIFOLS, S.A.;GRIFOLS INC.;TALECRIS BIOTHERAPEUTICS, INC.;REEL/FRAME:026390/0193
Effective date: 20110601
|Feb 27, 2014||AS||Assignment|
Owner name: DEUTSCHE BANK AG NEW YORK BRANCH, AS COLLATERAL AG
Free format text: SECURITY AGREEMENT;ASSIGNORS:GRIFOLS INC.;GRIFOLS THERAPEUTICS INC.;GRIFOLS-CHIRON DIAGNOSTICS CORP.;REEL/FRAME:032367/0001
Effective date: 20140227
|Mar 3, 2015||FPAY||Fee payment|
Year of fee payment: 8