|Publication number||US7326236 B2|
|Application number||US 10/746,466|
|Publication date||Feb 5, 2008|
|Filing date||Dec 23, 2003|
|Priority date||Dec 23, 2003|
|Also published as||CA2548188A1, EP1696827A2, EP1696827A4, EP1696827B1, US8585747, US20050149159, US20080091257, US20140188205, WO2005065200A2, WO2005065200A3, WO2005065200A8|
|Publication number||10746466, 746466, US 7326236 B2, US 7326236B2, US-B2-7326236, US7326236 B2, US7326236B2|
|Inventors||Bernard Andreas, Joseph Karratt, James R. Flom, Bradley Blackwood|
|Original Assignee||Xtent, Inc.|
|Export Citation||BiBTeX, EndNote, RefMan|
|Patent Citations (105), Non-Patent Citations (5), Referenced by (134), Classifications (15), Legal Events (6)|
|External Links: USPTO, USPTO Assignment, Espacenet|
The present invention relates generally to interventional catheters and prostheses, and more specifically to catheters and prostheses for treatment of vascular diseases, including coronary artery disease and peripheral vascular disease, as well as diseases of other body lumens such as the biliary tract, fallopian tubes, urinary and digestive tracts, and other structures.
Balloon angioplasty and stenting are widely used in the treatment of coronary artery disease and peripheral vascular disease. In coronary artery disease, one or more coronary blood vessels become narrowed or closed due to the buildup of stenotic plaques on the arterial wall. This blocks blood flow to the heart muscle, potentially causing myocardial infarction. Such narrowing can also occur in peripheral blood vessels such as the carotids, femorals, iliacs and other arteries, blocking the blood supply to other vital tissues and organs.
Balloon angioplasty involves the use of a long flexible catheter having a balloon at its distal tip. The catheter is inserted into a peripheral artery such as the femoral and advanced transluminally into the diseased artery. The balloon is inflated within the narrowed portion of the vessel, thereby expanding the vascular lumen and restoring normal blood flow.
In some cases, however, balloon angioplasty alone is inadequate to treat vascular disease due to restenosis, the renarrowing of the artery following angioplasty. Stents have been developed to provide an intravascular frame or scaffold to maintain patency of the vascular lumen after it has been expanded. Stents are small tubular prostheses designed to be advanced to the treatment site in a collapsed configuration using an elongated delivery catheter. The stents are then expanded at the treatment site into engagement with the vessel wall to maintain vascular patency.
Stents may be either self-expanding or balloon expandable. Self-expanding stents are made of a shape memory material such as Nitinol and can be delivered in a compressed state within the tip of the delivery catheter and allowed to resiliently expand upon release from the delivery catheter. Balloon expandable stents are made of a malleable metal and are mounted to a balloon on the delivery catheter. When positioned at the treatment site, the balloon is inflated to expand the stent into engagement with the vessel.
Stents, however, have also suffered from the problem of restenosis. Restenosis rates with conventional coronary stents have ranged from 30-40%. The causes of such restenosis are not fully understood. However, it is believed that restenosis may be caused in some cases by the excessive stiffness of current stents and their inability to conform to vascular curves, shapes, dimensional changes, and movements. This problem is particularly acute with longer lesions, which may extend over curved and tapered sections of a vessel and may be subject to non-uniform movements along their lengths.
The need has thus been demonstrated for highly flexible stents that may be used to treat long, curved, and tapered vascular regions. In co-pending U.S. patent application Ser. No. 10/637,713, filed Aug. 8, 2003, entitled “Apparatus and Methods for Delivery of Vascular Prostheses, the full disclosure of which is incorporated herein by reference, highly flexible multi-segmented stents and associated delivery devices are disclosed that enable the treatment of long, curved or tapered vascular lesions. The disclosed delivery devices enable the selective deployment of one or more stent segments at a treatment site to allow the user to customize stent length in situ. Moreover, the device can be repositioned at multiple vascular sites to deploy a plurality of stents of various lengths.
Other custom-length stents and delivery devices are described in co-pending U.S. patent application Ser. No. 10/624,451, filed Jul. 21, 2003, entitled “Apparatus and Methods for Delivery of Multiple Distributed Stents,” which is also incorporated herein by reference. This application describes separable stent segments as well as continuous prosthesis structures configured as braids or coils that allow the user to pay out a selected length of the prosthesis structure and deploy it into the vessel at one or more treatment sites.
Variable length angioplasty devices have also been proposed. For example, U.S. Pat. No. 5,246,421 to Saab discloses angioplasty catheters having an elongated balloon and an external sheath that is axially slidable relative to the balloon. The sheath can be retracted to expose a selected length of the balloon for expansion at a treatment site. The catheter can then be repositioned and another length of balloon exposed to treat one or more additional sites.
While such custom-length stents and angioplasty catheters have shown great promise, there remains a need for improved ways of controlling and providing indication of balloon and stent length in such devices. Conventional angioplasty and stenting procedures rely upon the use of fluoroscopy to visualize the location and operation of catheters and prostheses. However, fluoroscopy often fails to provide the clarity, resolution, and precision that are required for the accurate control of stent or balloon length, which in many cases must be controlled within a few millimeters. Moreover, even if visualization were adequate, the user is left to control stent or balloon length by manually manipulating the associated catheters, an operation not well-suited to highly precise control.
The invention provides devices and methods for controlling and indicating the length of an interventional element on a medical device such as a catheter. The devices and methods facilitate accurate control of the working or deployed length of an interventional element by providing highly precise and ergonomic mechanisms for adjusting the length, and by providing indication devices to give the user accurate indications of the length in real time. The types of interventional elements to which the invention may be applied are many, but in preferred embodiments include stents and balloons for the treatment of vascular disease.
In a first aspect of the invention, an interventional catheter comprises an elongated flexible shaft having a distal end and a proximal end, and an interventional element at the distal end, the interventional element having an adjustable length. An actuator is disposed near the proximal end for adjusting the length of the interventional element; and an indication device is disposed near the proximal end for indicating the length to a user. In an exemplary embodiment, the interventional element comprises a balloon. A sheath is movably disposed over the balloon and the actuator is coupled to the sheath to axially reposition the sheath relative to the balloon. In this way the sheath may be used to selectively cover part of the balloon while exposing part of the balloon having a desired length, the sheath constraining the covered part from expansion.
In a further embodiment, the interventional element comprises a stent releasably carried by the shaft. The actuator controls the length of a deployable portion of the stent, the deployable portion being released from the shaft while an undeployed portion of the stent remains associated with the shaft. In one embodiment, the actuator is coupled to a sheath which may be axially positioned to cover a first portion of the stent while a second portion of the stent having a desired length is left uncovered for deployment. The stent may be either balloon expandable or self-expanding. In a preferred embodiment, the stent is comprised of a plurality of separable stent segments and stent length is controlled by exposing a desired number of stent segments outside of the sheath.
In one embodiment, the actuator is movable through a distance correlated with the length. For example, the actuator may be movable through a stroke, each stroke of the actuator adjusting the length a predetermined amount. The actuator may also be configured to allow the length to be adjusted in a first direction and prevent or limit the adjustment of length in a second direction. For example, the actuator may comprise a ratchet mechanism that allows the actuator to move in a first direction to increase the length of the interventional element, but prevents the actuator from moving in the reverse direction to decrease the length.
In some embodiments the indication device is coupled to the actuator. For example, the indication device may comprise a stop that limits the movement of the actuator, thus providing the user a tactile indication of the length. Alternatively, the indication device may comprise a sensor that senses movement of the actuator. Further, the indication device may comprise a visual indicator coupled to the actuator (or to a sensor associated with the actuator) to provide a visual indication of the length of the interventional element based on the actuator position.
The indication device may alternatively comprise a sensor that detects the length of the interventional element. In one embodiment, the sensor may be disposed near the distal end of the shaft and is coupled to an indicator at the proximal end, the indicator being a display or other output device. The sensor may be mechanical, optical, magnetic, inductive, or other suitable type for detecting the length of the interventional element. The output device may provide a visual, audible, tactile, or other signal to the user.
In a further aspect, the indication device comprises a plurality of holes and a movable detent associated with the shaft, each hole being configured to receive the detent, whereby adjusting the length moves the detent from one hole to another hole. As the detent moves from one hole to the next, the reception of the detent in one of the holes provides a tactile indication of the length of the interventional element. In embodiments where a sheath is movably disposed over the shaft to adjust the length of a balloon, stent or other interventional element, the detent or the holes may be disposed on the sheath such that axial movement of the sheath moves the detent from hole to hole.
In a further aspect, the invention provides a stent delivery catheter comprising an elongated flexible shaft having distal and proximal ends and a stent releasably mounted at the distal end, a deployable portion of the stent being releasable from the catheter to assume an expanded configuration, the deployable portion having a length. An actuator is disposed near the proximal end for controlling the length of the deployable portion, and an indication device is disposed on the catheter for indicating the length of the deployable portion to the user.
In some embodiments the actuator is movable through a distance correlated with the length of the portion of the stent to be deployed. For example, the actuator may be movable through a stroke corresponding to a preselected length. This allows the actuator to be actuated repeatedly to adjust the length of the stent to a desired multiple of the preselected length. In exemplary embodiments the stent comprises a plurality of stent segments, and the stroke corresponds to a segment length of one of the stent segments.
The invention contemplates various types of indication devices associated with the catheter. In one embodiment, the indication device comprises a stop that limits the movement of the actuator, thus providing a tactile indication of the length. The actuator or ratchet mechanism may also be configured to emit an audible sound such as a click that indicates the number of strokes or the distance through which the actuator has moved. The indication device may also comprise a plurality of holes or slots and a movable detent, each hole or slot being configured to receive the detent in a manner that can be felt by the user. The indication device may also comprise a sensor for detecting the length of the interventional element. The sensor may be disposed in various locations along the shaft of the interventional device and is usually coupled to an indicator at the proximal end. The sensor may be mechanical, optical, magnetic, inductive, or other suitable type. A display or other output means may be associated with the sensor for providing a visual, audible, tactile, or other indication of the length. The indication device may be configured to indicate a length of the deployable portion of the stent, the number of stent segments in the deployable portion, the number of stent segments (or length of stent) remaining undeployed in the catheter, and other information.
In embodiments in which the stent comprises a plurality of separable stent segments, the actuator may be adapted to axially separate a first stent segment from a second stent segment prior to expansion thereof. This allows the second segment to be expanded and deployed without deploying or interfering with the first segment. In an exemplary embodiment, the actuator has a first position in which it is movable for controlling the number of stent segments in the deployable portion, and a second position in which it is movable for controlling the separation between the first and second stent segments.
The invention further provides methods of using an interventional catheter at a target site in a patient's body. In a first aspect, the method comprises positioning an interventional element of the interventional catheter near the target site with a proximal portion of the interventional catheter being disposed outside the patient's body. A working length of the interventional element is then adjusted with the interventional element remaining positioned in the patient's body. An indication of the working length of the interventional element is received from the proximal portion of the interventional catheter; and, after receiving the indication, the interventional element is deployed.
In exemplary embodiments, the interventional element comprises a balloon, and adjusting the working length comprises constraining a first portion of the balloon from expansion while leaving a second portion of the balloon unconstrained from expansion. Preferably, constraining a first portion of the balloon comprises covering the first portion of the balloon by a sheath movably disposed on the interventional catheter. The indication of the working length then comprises an indication of the length of the second portion.
In some embodiments, the sheath is coupled to an indicator, and the indication of working length being received from the indicator, wherein moving the sheath changes the indication received from the indicator. Receiving the indication of working length may comprise observing a visual indication, hearing an audible indication, feeling a tangible indication, or otherwise receiving a signal from the catheter indicative of the working length. A visual indication may comprise one or more indicia displayed electronically, mechanically, or otherwise on the proximal portion of the interventional catheter. A tactile indication of working length may be received from a detent engaging a hole or other structure associated with the interventional catheter. An audible indication of working length may be received from a clicker or other noise emitter associated with the actuator.
The method may further include, after deploying the interventional element, positioning the interventional element near a second target site; adjusting the working length of the interventional element to a second working length; receiving from the interventional catheter a second indication of the second working length; and after receiving the second indication, re-deploying the interventional element.
In a further aspect of the invention, a method of deploying a stent at a target site in a patient's body comprises positioning a distal end of a delivery catheter near the target site, the stent being releasably coupled to the distal end, a proximal portion of the delivery catheter being disposed outside the patient's body; adjusting the length of a deployable portion of the stent with the delivery catheter positioned in the patient's body; receiving an indication of the length from the proximal portion of the delivery catheter; and after receiving the indication, deploying the deployable portion of the stent at the target site. The indication of working length may be received visually, audibly, tactilely, or in another humanly detectable manner.
Adjusting the length of the deployable portion may comprise moving an actuator associated with the proximal portion of the delivery catheter through a distance correlated with the length. For example the actuator may be movable through a stroke, each stroke of the actuator adjusting the length a predetermined amount. The stent may comprise a plurality of stent segments, and the stroke may then correspond to a segment length of one of the stent segments. The indication device may comprise a stop that limits the movement of the actuator, thus providing tactile indication of length.
The indication of the length may be received from an output device associated with the proximal end of the catheter. The output device may be coupled to a sensor, and the method further comprises detecting the length with the sensor. The sensor may be disposed in any suitable location in the catheter, but in an exemplary embodiment is disposed near the distal end of the delivery catheter in proximity to the stent. The sensor may detect the length mechanically, optically, magnetically, inductively, or in other ways. In other embodiments, the tactile indication is received from a detent engaging a hole associated with the delivery catheter.
In some embodiments, the stent comprises separable stent segments, and adjusting the length comprises constraining at least a first stent segment from expansion while leaving at least a second stent segment unconstrained from expansion. Adjusting the length may comprise moving a sheath relative to the stent segments for selectively covering the first stent segment and exposing the second stent segment. In such embodiments, the indication of length may be correlated with the number of stent segments. Alternatively, the indication of length may be correlated with movement of the sheath relative to the stent.
The method of the invention may further include axially separating the first stent segment from the second stent segment prior to expansion thereof. Such separation may be accomplished using an actuator associated with the proximal portion of the delivery catheter. The actuator may be movable to a first position for controlling the number of stent segments in the deployable portion and further movable to a second position for controlling the separation between the first and second stent segments.
Further aspects of the nature and advantages of the invention will be appreciated from the following detailed description taken in conjunction with the drawings.
The invention provides devices and methods for manipulation of interventional catheters with greater control, precision, and visibility. In one aspect, the devices and methods of the invention facilitate controlling the working length of an interventional element on a catheter and indicating the working length to the user. In an exemplary embodiment, the interventional element is an expandable member such as a balloon for dilatation of vascular lesions. The interventional element also may comprise a stent or series of stent segments. However, the principles of the invention will have applicability to various types of interventional elements for use in various parts of the body, wherever highly precise catheter manipulation and control and visibility of working length may be desirable.
A plurality of stent segments 46 are slidably positioned over expandable member 30. Pusher 36 is axially slidable relative to inflation shaft 34 and engages stent segments 46 at its distal end 48. Pusher 36 may be pushed distally to advance stent segments 46 over expandable member 30, or pusher 36 may be held in a stationary position while expandable member 30 is drawn proximally relative to stent segments 46. Sheath 38 is axially movable relative to expandable member 30, pusher 36, and stent segments 46. Sheath 38 may be repositioned proximally or distally to selectively expose a desired length of the expandable member and stent segments thereon according to the length of the lesion to be treated. Sheath 38 and pusher 36 may be drawn proximally in tandem relative to expandable member 30 to separate stent segments 46 exposed distally of sheath 38 from stent segments 46 held within sheath 38. Various other aspects of the construction of delivery catheter 20 and stent segments 46 are described in copending application Ser. No. 10/637,713, filed Aug. 8, 2003, which has been incorporated herein by reference.
A stent valve 50 is mounted to the interior of sheath 38 and is preferably spaced proximally from the distal end 52 of sheath 38 a distance equal to the length of about ½-1 stent segment. Stent valve 50 comprises an annular ridge configured to frictionally engage stent segments 46 to facilitate control of the spacing between those segments to be deployed distally of sheath 38 and those to be retained within sheath 38. Stent valve 50 may also comprise any of the structures described in copending application Ser. No. 10/412,714, filed Apr. 10, 2003, which is incorporated herein by reference.
Handle 28 includes an actuator knob 54 rotatably coupled thereto. A post 56 is mounted to handle 28 so as to be extendable distally out of the handle and retractable proximally into the handle. Sheath 39 is attached to post 56. Rotation of actuator knob 54 extends or retracts post 56, thereby moving sheath 38 relative to expandable member 30. A lever 58 is pivotably coupled to handle 28 and is movable between a first position in which rotation of actuator knob 54 moves only sheath 38, and a second position in which rotation of actuator knob 54 moves both sheath 38 and pusher 36 relative to expandable member 30, as described more fully below.
A plurality of indicia 60 are disposed on post 56. Indicia 60 comprise alphanumeric symbols or other appropriate indicators of the length of expandable member exposed distally of sheath 38 and/or the number or length of stent segments 46 exposed for deployment. As described more fully below, a pointer or other reference object may be used that points to the appropriate location among indicia 60 corresponding to the number or length of stent segments 46 that have been exposed; preferably such pointer is adapted to compensate for retraction of sheath 38 in tandem with pusher 36, during which additional stent segments are not exposed distally of sheath 38, as described more fully below.
A luer fitting 62 is mounted to a proximal end of handle 28 and is in fluid communication with an inflation lumen (not shown in
In a further embodiment, illustrated in
In the embodiment of
Pusher 36 extends slidably through post 56 as described above and is fixed at its proximal end to a puck 98. Puck 98 is pivotably coupled to a brake 100, which is slidably mounted to a rail 102. Rail 102 is coupled to lever 58 at its proximal end and to a hinge 104 at its distal end such that movement of lever 58 from the down position of
Brake 100 has a plurality of teeth 108, 110 along opposing lateral edges thereof, as seen in
Referring now to
In an alternative embodiment, illustrated in
In a further embodiment, stent delivery catheter 20 includes a ratchet mechanism serving to provide an audible and/or tangible indication of sheath retraction, as well as to limit travel of the sheath to a single direction (e.g. proximal). Preferably the ratchet may be selectively enabled, so that the ratchet is engaged when sheath 38 is retracted relative to pusher 36, but is disengaged when sheath 38 and pusher 36 are retracted together relative to expandable member 30. In an exemplary embodiment, illustrated in
The interventional catheters of the invention may further include sensory devices for detecting the relative positions of catheter components, the length of balloon or stent exposed for deployment, the number of stent segments exposed, and other parameters. In a first embodiment illustrated in
It should be noted that sensor 140 may be placed in virtually any location along the extremity of delivery catheter 20 from handle 28 to expandable member 30. Preferably, however, sensor 140 is located near the distal end of delivery catheter 20. This has the advantage of providing a precise indication of the actual displacement of sheath 38 near the distal end, without distortion as a result of the stretching or compression of sheath 38, pusher 36, or inflation shaft 34. In another configuration, illustrated in
In a further embodiment, illustrated in
In another embodiment, illustrated in
In a preferred embodiment, switch 164 is adapted to enable the user to select the desired amount of sheath retraction, whereupon motor 160 will automatically retract sheath 38 the appropriate amount. For example, switch 164 could be pressed once to retract the sheath the length of one stent segment, twice for two stent segments, etc. Alternatively, a dial or sliding switch could be used so that various switch positions or the degree of switch displacement corresponded to the desired amount of retraction. In these embodiments, motor 160 could include a feedback loop from its encoder so that motor 160 automatically rotated drive shaft 162 the amount needed to achieve the desired degree of sheath retraction.
It will be understood that detents and similar features to provide tactile feedback to the user as the length of the interventional element (stent, balloon, etc.) is adjusted may be positioned in various places in the handle or shafts of the interventional catheters of the invention. In still another embodiment, not illustrated, a series of detent holes may be positioned in a circular pattern on the underside of knob 54, and a spring-loaded ball plunger may be mounted to handle 28 in alignment with the detent holes so as to be received therein as knob 54 is rotated. In this way, the user will feel a “bump” or “click” each time the ball plunger engages one of the detent holes. Again, the spacing of the detent holes may be selected to correspond with a known distance such as the length of one of stent segments 46 to provide an indication of the length of the interventional element as it is exposed for deployment.
In operation, trigger 182 is pulled proximally by the user, thereby rotating ratchet wheel 184. Pawls 188 engage inner one-way teeth 198, turning lower gear 196 in a counter-clockwise direction. Outer teeth 200 engage teeth 202, turning upper gear 201 in a clockwise direction, thereby moving post 56 in a proximal direction relative to handle housing 90. This retracts sheath 38 relative to inflation shaft 34, exposing stent segments 46. The location of stop 194 can be selected so that each stroke of trigger 182 exposes a desired length of balloon or stent. For example, each trigger stroke may correspond to the length of one stent segment 46, allowing the user to actuate the trigger once for each stent segment s/he wishes to deploy. When trigger 182 is released, spring 190 pulls it back in the distal direction and pawls 188 are deflected and slide over inner one-way teeth 198 so that post 56 and sheath 38 remain in the retracted position.
A further embodiment of a ratchet mechanism for one-way deployment of an interventional element according to the invention is illustrated in
It will be understood that various types of mechanisms may be used to provide one-way actuation in the interventional catheter of the invention. In another exemplary embodiment, not illustrated, a unidirectional roller clutch may be used to couple knob 54 to pinion gear 96 (or to a shaft fixed thereto). Such a roller clutch transmits torque in a first direction while overrunning freely in the opposite direction. In this way, when rotated in a first direction knob 54 turns pinion gear 96 thereby retracting sheath 38, but when rotated in the opposite direction knob 54 turns freely without turning pinion gear 96. Suitable unidirectional roller clutches are available from, e.g., Stock Drive Products, www.sdp-si.com.
While the above is a complete description of the preferred embodiments of the invention, it will be appreciated that various alternatives, modifications, additions and substitutions are possible without departing from the scope of the invention, which is defined by the claims.
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|International Classification||A61M25/01, A61F2/06, A61F2/00, A61F2/84|
|Cooperative Classification||A61M2025/0008, A61F2/95, A61M25/0136, A61F2250/0097, A61M2025/1068, A61F2002/9517, A61F2/966|
|European Classification||A61F2/95, A61F2/966, A61M25/01C10A|
|Dec 9, 2004||AS||Assignment|
Owner name: XTENT, INC., CALIFORNIA
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:ANDREAS, BERNARD;KARRATT, JOSEPH;FLOM, JAMES R.;AND OTHERS;REEL/FRAME:015444/0482;SIGNING DATES FROM 20040608 TO 20040615
|Sep 12, 2011||REMI||Maintenance fee reminder mailed|
|Oct 26, 2011||FPAY||Fee payment|
Year of fee payment: 4
|Oct 26, 2011||SULP||Surcharge for late payment|
|Feb 7, 2012||AS||Assignment|
Owner name: J.W. MEDICAL SYSTEMS LTD., CHINA
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:XTENT, INC.;REEL/FRAME:027668/0093
Effective date: 20111227
|Jul 31, 2015||FPAY||Fee payment|
Year of fee payment: 8