|Publication number||US7508967 B2|
|Application number||US 11/110,461|
|Publication date||Mar 24, 2009|
|Filing date||Apr 20, 2005|
|Priority date||Oct 14, 2004|
|Also published as||US20060083349|
|Publication number||110461, 11110461, US 7508967 B2, US 7508967B2, US-B2-7508967, US7508967 B2, US7508967B2|
|Inventors||Paul M. Harari, Wolfgang A. Tome, Shiyu Song|
|Original Assignee||Wisconsin Alumni Research Foundation|
|Export Citation||BiBTeX, EndNote, RefMan|
|Patent Citations (15), Non-Patent Citations (4), Referenced by (7), Classifications (7), Legal Events (3)|
|External Links: USPTO, USPTO Assignment, Espacenet|
This application is based on provisional application Ser. No. 60/618,846 filed Oct. 14, 2004 and entitled Radiation Treatment Planning Using Conformal Avoidance.
This invention was made with United States government support awarded by the following agencies; NIH CA88960. The United States has certain rights in this invention.
The present invention relates generally to radiation therapy planning for the treatment of tumors, and in particular, radiation treatment planning for radiation therapy machines that provide independent intensity modulation of many narrow beams of radiation.
External beam radiation therapy involves the treatment of tumorous tissue with high-energy radiation according to a treatment plan. The treatment plan controls the radiation's placement and intensity, and thus the dose level to volume elements of tissue within a treatment volume so that the tumorous tissue within the treatment volume receives a sufficient dose of radiation while radiation to the surrounding and adjacent non-tumorous tissue is minimized.
Intensity modulated radiation therapy (IMRT) treats a patient with multiple smaller rays of radiation, each substantially smaller than the treatment volume and independently controllable in intensity and/or energy. The rays are directed at different angles at the patient and combined to produce the desired dose pattern. Typically, the radiation source consists of either high energy x-rays, electrons from certain linear accelerators, or gamma rays from highly focused radioisotopes such as Co60.
Radiation plays a central role in the treatment of head and neck (H&N) cancer patients. Conventional H&N radiation treatment is associated with substantial toxicity to normal tissue, and IMRT provides the opportunity to deliver radiation in H&N with enhanced conformance to tumor targets while diminishing the radiation dose to the surrounding normal tissue structures. Unfortunately, tumor target definition in H&N cancer is complex and the delivery of IMRT requires accurate and thorough target definition. Experienced H&N cancer specialists commonly consume several hours to fully contour and refine desired targets for a single H&N IMRT case. A substantial part of the complexity arises from the need to define not only the gross tumor volume (GTV) containing the tumor, but also to describe a contour containing surrounding lymph nodes. The lymph nodes can be very difficult to image and thus to distinguish from other tissue.
The complexity of the planning process associated with IMRT, a particularly in H&N IMRT may discourage the use of highly effect IMRT techniques.
The present invention provides a radiation treatment planning method which reverses the process normally used for treatment planning from that of describing the tumor volume and in some cases the surrounding lymph node areas, to one of describing areas of normal tissue and subtracting those areas from an encompassing field covering both normal and tumorous tissue types. Normal tissue structure in H&N treatment such as salivary glands and the spinal cord are more clearly defined in image studies and therefore easier to contour reproducibly than less well defined elective nodal or “at risk regions”. Physician planning time, using this method, can be reduced by as much as three times, and preliminary analysis in H&N planning shows that salivary gland and spinal cord protection is equivalent to that achieved with a conventional “target definition” approach. The method of the present invention may also have application outside of the head and neck area.
Specifically then, the present invention provides a method of radiation planning comprising steps of obtaining an image of the patient encompassing tumorous and non-tumorous tissue and applying an encompassing field to the image having an area covering the tumorous and non-tumorous tissue. A graphical user interface is used by a physician to define a subset field of normal tissue for subtraction from the encompassing field. The resulting treatment area may then be input to a computer program (being separate or the same as that providing for the graphical user interface) to generate a radiation treatment plan using at least one prescribed dose to the treatment area.
It is thus one object of at least one embodiment of the invention to improve the acceptance of IMRT in head and neck cancer treatment or any treatment where complex treatment areas must be created by simplifying treatment planning.
It is another object of at least one embodiment of the invention to allow treatment area definition based on the more easily identified structure of normal tissue rather than the often more difficult to identify tumor tissues and surrounding elective areas.
The method may include the step of using the graphical user interface to subdivide the treatment area into at least two zones and applying different prescribed doses to the zones.
Thus it is another object of at least one embodiment of the invention to allow rapid treatment planning while allowing a set of different doses within the treatment area.
The encompassing field may be a slice through the head and neck region defined by the exposure area of two counterdirected beams from the particular radiation therapy equipment, the beams extending along a lateral access through the head and neck region.
Thus it is one object of at least one embodiment of the invention to provide an extremely simple definition of the encompassing field for H&N treatment using a beam configuration familiar to H&N.
The image may be a medial slice through the head and neck region and the subset fields may be selected from the group covering a spinal cord, parotid gland, mandible, and area outside the mandible.
Thus it is another object of at least one embodiment of the invention to use subset fields matched to readily identifiable anatomical structures.
The encompassing field may be applied to the image by tracing a periphery of the desired encompassing field. This tracing may be done manually or by automatic techniques following, for example, an isodose line of the unmodulated beams.
Thus it is another object of at least one embodiment of the invention to provide a simple method of rapidly defining an encompassing field.
Alternatively, the encompassing field may be a predefined pattern from a library of encompassing fields for different procedures and the step of applying the encompassing field may be the step of fitting one encompassing field from the library to the patient image based on anatomical landmarks. For example, the fitting may be a translation and rotation of the selected encompassing field or a warping of the selected encompassing field. A similar procedure may be adopted for defining the subset fields.
Thus it is another object of at least one embodiment of the invention to provide a rapid method of creating treatment plans by reusing general encompassing fields and/or subset fields that will fit a wide variety of patients with simple modification.
These particular objects and advantages may apply to only some embodiments falling within the claims and thus do not define the scope of the invention.
Referring now to
For head and neck radiation therapy, the radiation source 10 may be positioned alternately on left and right lateral sides of a patient's head and neck 16 at lateral positions 18 a and 18 b opposed about the head and neck 16 to irradiate a tumor volume 20 and the region 22 surrounding the tumor.
Referring also to
Referring now to
The memory 32 may also hold a series of CT slice images 46 taken of the patient along each of the slices 26 per
Referring now to
Generally, the tumor volume may be identified by tracing on each CT slice image 46 a boundary surrounding the tumor. The tracings for each slice are then joined into the tumor volume 20 by interpolation between slices.
The lateral field 28 describes for each of the slices 26, a collimated anterior-posterior width of the beam 12. The beam width is set to amply cover the tumor volume 20 and a margin of tissue around the tumor volume 20 sufficient to cover any elective treatment area. So long as the lateral field 28 is reasonably generous, it need not be precisely set because actual dose within the lateral field 28 will be further controlled by the modulation of the radiation beams.
The lateral field 28 is most easily defined by creating a lateral image 48 (shown in
Referring now to
As will be seen from
Other methods of defining the encompassing field 65 may be used including a simple tracing or painting process well known to those in the graphical imaging art or application of a library of pre-defined fields from a library as will be described below.
Referring now to
Alternatively, a standard library subset field may be used and library subset fields fit to the anatomical structures of the CT slice images 46 as will be described below.
Referring now to
At this time, the encompassing field 65 may be partitioned by the drawing of a partition line 73 to create two distinct dose regions 80 a near the tumor volume 20 and 80 b further removed from the tumor volume 20. Each of these regions may be assigned a different dose. The tumor volume 20 may be individually contoured and given a separate dose definition.
Referring again to
A preliminary analysis of the use of this technique as shown in the following Table 1 indicates that the “subtractive” approach of the present invention is a substantial improvement over conventional non-IMRT treatment and is comparable to “target definition” IMRT which is substantially more time consuming than the present invention.
Referring now to
It is specifically intended that the present invention not be limited to the embodiments and illustrations contained herein, but include modified forms of those embodiments including portions of the embodiments and combinations of elements of different embodiments as come within the scope of the following claims.
|Cited Patent||Filing date||Publication date||Applicant||Title|
|US5724400 *||Jan 25, 1996||Mar 3, 1998||Wisconsin Alumni Research Foundation||Radiation therapy system with constrained rotational freedom|
|US6152599 *||Oct 21, 1998||Nov 28, 2000||The University Of Texas Systems||Tomotherapy treatment table positioning device|
|US6504899 *||Sep 25, 2001||Jan 7, 2003||The Board Of Trustees Of The Leland Stanford Junior University||Method for selecting beam orientations in intensity modulated radiation therapy|
|US6546073 *||Nov 6, 2000||Apr 8, 2003||Georgia Tech Research Corporation||Systems and methods for global optimization of treatment planning for external beam radiation therapy|
|US6697452 *||Feb 15, 2002||Feb 24, 2004||The Board Of Trustees Of The Leland Stanford Junior University||Verification method of monitor units and fluence map in intensity modulated radiation therapy|
|US6704440 *||Jun 24, 1999||Mar 9, 2004||General Electric Company||Method and apparatus for processing a medical image containing clinical and non-clinical regions|
|US20020080912 *||Jan 4, 2002||Jun 27, 2002||Mackie Thomas R.||Method and apparatus for calibration of radiation therapy equipment and verification of radiation treatment|
|US20020080915 *||Oct 1, 2001||Jun 27, 2002||Stephan Frohlich||Radiotherapy treatment planning with multiple inverse planning results|
|US20020193685 *||Jun 8, 2001||Dec 19, 2002||Calypso Medical, Inc.||Guided Radiation Therapy System|
|US20030191384 *||Jul 20, 2001||Oct 9, 2003||Svatos Michelle Marie||Automated delivery of treatment fields|
|US20030212325 *||Mar 12, 2003||Nov 13, 2003||Cristian Cotrutz||Method for determining a dose distribution in radiation therapy|
|US20040073107 *||Oct 29, 2002||Apr 15, 2004||Ion Beam Applications S.A.||Elongated markers for soft tissue volume identification|
|US20040254773 *||Nov 6, 2003||Dec 16, 2004||Tiezhi Zhang||Apparatus and method using synchronized breathing to treat tissue subject to respiratory motion|
|WO1998017349A1 *||Oct 24, 1997||Apr 30, 1998||Nomos Corporation||Planning method and apparatus for radiation dosimetry|
|WO2005057463A1 *||Dec 10, 2004||Jun 23, 2005||The University Of Western Ontario||Method and system for optimizing dose delivery of radiation|
|1||Aldridge, Jennifer Stacy, Tomographic Patient Registration & Conformal Avoidance Tomotherapy, UMI Microform 9956235, 1999, Bell & Howell Information and Learning Company, Ann Arbor Michigan.|
|2||*||Mackie, Rock, "IMRT", International Workshop In IMRT 2002, pp. 1-16, slides 1-95.|
|3||*||Mackie, Thomas Rockwell et al., "Image Guidance For Precise Conformal Radiotherapy." Elsevier Inc., Int. J. Radiation Oncology Biol. Phys., Apr. 8, 2003, vol. 56, No. 1, pp. 89-105.|
|4||*||Tome, Wolfgang et al., "Optically guided intensity modulated radiotherapy" Elsevier Inc., Radiotherapy and Oncology, vol. 61, Issue 1, Oct. 2001, pp. 33-44.|
|Citing Patent||Filing date||Publication date||Applicant||Title|
|US8285012 *||Apr 25, 2006||Oct 9, 2012||Hitachi Medical Corporation||Image display apparatus and program|
|US8401148||Oct 29, 2010||Mar 19, 2013||Tomotherapy Incorporated||Non-voxel-based broad-beam (NVBB) algorithm for intensity modulated radiation therapy dose calculation and plan optimization|
|US8442287||Aug 10, 2010||May 14, 2013||Tomotherapy Incorporated||Method and system for evaluating quality assurance criteria in delivery of a treatment plan|
|US9443633||Feb 19, 2014||Sep 13, 2016||Accuray Incorporated||Electromagnetically actuated multi-leaf collimator|
|US9811902 *||Oct 10, 2014||Nov 7, 2017||Siemens Aktiengesellschaft||Determining a value of a recording parameter by use of an anatomic landmark|
|US20100215225 *||Apr 25, 2006||Aug 26, 2010||Takayuki Kadomura||Image display apparatus and program|
|US20150104092 *||Oct 10, 2014||Apr 16, 2015||Siemens Aktiengesellschaft||Determining a value of a recording parameter by use of an anatomic landmark|
|U.S. Classification||382/128, 378/65|
|International Classification||G06K9/00, A61N5/10|
|Cooperative Classification||A61N5/103, A61N5/1042|
|Jul 19, 2005||AS||Assignment|
Owner name: WISCONSIN ALUMNI RESEARCH FOUNDATION, WISCONSIN
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:HARARI, PAUL M.;TOME, WOLFGANG A.;SONG, SHIYU;REEL/FRAME:016282/0312;SIGNING DATES FROM 20050131 TO 20050308
|Aug 24, 2012||FPAY||Fee payment|
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|Aug 26, 2016||FPAY||Fee payment|
Year of fee payment: 8