|Publication number||US7628954 B2|
|Application number||US 11/122,280|
|Publication date||Dec 8, 2009|
|Filing date||May 4, 2005|
|Priority date||May 4, 2005|
|Also published as||CA2606050A1, CA2606050C, CA2947790A1, DE602006006175D1, EP1883822A2, EP1883822B1, EP2053410A2, EP2053410A3, US9057714, US20060263248, US20100111765, US20150268259, WO2006119361A2, WO2006119361A3|
|Publication number||11122280, 122280, US 7628954 B2, US 7628954B2, US-B2-7628954, US7628954 B2, US7628954B2|
|Inventors||Cordell Kay Gomm, Paul Luoma II Robert, David Charles Arnquist, Ryan Patrick Johnson|
|Original Assignee||Abbott Laboratories, Inc.|
|Export Citation||BiBTeX, EndNote, RefMan|
|Patent Citations (101), Referenced by (20), Classifications (13), Legal Events (3)|
|External Links: USPTO, USPTO Assignment, Espacenet|
The present invention is directed toward testing of specimens, and particularly toward an apparatus for automatically handling fluids such as reagents which are to be used for such testing.
Testing sample biological specimens is commonly done to, for example, check for the presence of an item of interest, which item may be or include all or portions of a specific region of DNA, RNA, fragments, complements, peptides, polypeptides, enzymes, prions, proteins, messenger RNA, transfer RNA, mitochondrial RNA or DNA, antibodies, antigens, allergens, parts of biological entities such as cells, virons or the like, surface proteins, functional equivalents of the above, etc. Specimens such as a patient's body fluids (e.g., serum, whole blood, urine, swabs, plasma, cerebra-spinal fluid, lymph fluids, tissue solids) can be analyzed using a number of different tests to provide information about a patient's health.
In such testing, it is imperative that the specimens be handled in a manner which prevents contaminants from being introduced to the specimens, whether from the outside environment or between specimens. Obviously, where the HIV virus from one specimen is inadvertently allowed to contaminate the specimen of a different patient, the resulting false positive test result could potentially have catastrophic psychological effect on the patent, even should subsequent testing later discover the error. Moreover, since such testing is highly sensitive, even the smallest amounts of contamination can cause erroneous test results. In such sophisticated testing, it is also imperative that the various reagents which may be used in the testing be properly handled as well, not only to avoid contaminants but also to ensure that the proper reagent in proper quantities is used at appropriate times.
Commonly, such testing is accomplished using automated devices which handle multiple specimens and fluids (typically, reagents). For example, U.S. Pat. No. 6,588,625 B2 and U.S. Application Publication No. 2004/0005714 A1 (the disclosures of which are hereby incorporated by reference) variously disclose systems for handling fluids and specimens of this type.
Such automated devices often use sets of pipettes to move various fluids between their original containers (usually receptacles such as open topped tubes) and containers in which the specimens are to be processed. For example, a specimen may be contained in a tube loaded in a rack on the device, and a head carrying a pipette will through programmed motion move the pipettes into that tube, where a vacuum will be applied to extract a selected amount of the specimen from the tube into the pipette. The head will then retract the pipette from the tube and move over to another tube or reaction vessel located at a processing station, depositing the extracted amount of the specimen from the pipette into the reaction vessel. A similar process may be followed to acquire an appropriate reagent (depending upon the desired test) from a reagent supply.
At the processing station of such automated devices, the specimens are variously handled according to the purpose of the testing (e.g., incubated, prepared, lysed, eluted, analyzed, read, etc.). For example, the specimens may be prepared for analyzing, as for example by separating DNA or RNA from the specimen. The specimens may also or alternatively be analyzed. Commonly, such processes involve the addition of various fluids (typically reagents) to the specimen in each tube. For example, in a first step, a reagent may be added to each of the tubes to wash the specimens, and second and third (and more) reagents may be added to the specimens in the course of carrying out other processes to, for example, unbind and/or separate the DNA or RNA of interest allow so that it may be extracted from the specimen in each tube for subsequent testing. Similar processes, in which the same or different reagents are added to the tubes, may also occur after the specimen has been prepared as a part of the analyzing of the prepared specimens.
The handling of the reagents and other fluids can, with such automated devices, be problematic. Though the reagents can be automatically moved from receptacles to the specimen containing tubes in the processing station by use of the head and pipettes such as noted, it is in the first instance necessary to load the appropriate reagent into the appropriate receptacle on the device in order to ensure that the head and pipettes are adding the appropriate reagent to the appropriate specimen containing tube at the appropriate time in the process.
Heretofore, loading the appropriate reagent into the appropriate receptacle has been accomplished in several different ways. In one such procedure, the individual who is controlling the device manually measures and adds the reagents to receptacles, and then places those receptacles on the device. In another such procedure, the loading of reagents is automatically accomplished by the device itself, which uses some transfer apparatus (such as a head and pipette(s) as previously described) to move the reagents from bulk supplies of the reagents provided with the device. However, either of the above procedures can be problematic. For example, manually adding the reagents can introduce human error, such as mounting the reagent receptacle incorrectly on the device. Moreover, even if the reagents are correctly loaded in the correct amounts, they may be loaded at the wrong location on the device so that when the head and pipettes automatically draw a reagent for use at a certain step of the processing, it may well be the wrong reagent, or there could be no reagent of any kind where the head and pipettes go to extract it.
The Architect® i2000 systems of Abbott Laboratories of Abbott Park, Ill. is a high throughput analyzer providing automated operation in which the operator may be freed from interacting with the analyzer for long periods of time. With that device, bulk supplies of reagents can be manually loaded onto a refrigerated carousel, with the analyzer then automatically obtaining the desired samples and reagents for the processing station at which testing procedures are accomplished. The containers for the reagents and samples are barcoded for automatic tracking on the system. Each reagent container can contain sufficient reagents for many tests so that, depending upon usage and the types of tests most commonly performed, some reagent containers can be maintained on the carousel for long periods of time. Particularly for reagents which are made with suspended microparticles, consistent use and dosages may be negatively impacted due to settling of the microparticles over time.
The present invention is directed to improving upon the reagent and sample handling devices of the prior art testing systems such as described above.
In one aspect of the present invention, a handling device for samples and reagents to be used in testing in a system is provided, including at least one carrier for reagent containers, at least one carrier for sample containers, and a platform defining a plurality of locations on which the containers may be placed from a loading side for loading into the testing system. A position indicator at each location is biased upwardly toward a first position and cooperates with the platform whereby the position indicator is engaged by a carrier on the associated position of the platform wherein (a) the position indicator is in a second position when any carrier is only partially loaded at the associated location, (b) the position indicator is in a third position when a sample carrier is properly loaded at the associated location, and (c) the position indicator is in a fourth position when a reagent carrier is properly loaded at the associated location. A sensor detects the position of the position indicator.
In one form of this aspect of the invention, the sensor consists of first and second proximity sensors and the position indicator includes first and second ears aligned with the first and second proximity sensors, respectively. In the first position, the ears are spaced from the proximity sensors; in the second position, the first ear is proximate the first proximity sensor and the second ear is spaced from the second proximity sensor; in the third position, the first ear is proximate the first proximity sensor and the second ear is proximate the second proximity sensor; and in the fourth position, the first ear is spaced from the first proximity sensor and the second ear is proximate the second proximity sensor. In one further form, the position indicator is pivotally secured beneath the platform on one end and the ears are disposed on the other end of the position indicator. In another further form, the proximity sensors are electric eyes, and the ears are detected as proximate thereto when the electric eyes are blocked.
In another form of this aspect of the invention, the platform includes openings therethrough at each carrier location of the platform, and the position indicator includes projections extending through the openings and adapted to be selectively engaged by a sample carrier or reagent carrier in either a partially loaded position or a properly loaded position.
In a further form, the platform at each location includes a flat portion and a raised end at the loading side, and the projections include first and second knuckles. The first knuckle projects above the platform raised end a first distance when the position indicator is in the first position, and the second knuckle projects above the platform flat portion a second distance when the position indicator is in the first position. A partially loaded carrier rests on the raised end and engages the first knuckle to force the position indicator down the first distance to the second position, and one of the sample and reagent carriers when properly loaded on the platform engages the second knuckle to force the position indicator down the second distance to one of the third and fourth positions.
In a still further form, the platform locations include raised ledges along opposite sides of the platform flat portion, the raised ledges being adapted to support the other of the sample and reagent carriers above the flat portion when properly loaded. A third knuckle projects above the ledges a third distance when the position indicator is in the first position, whereby the other of the sample and reagent carriers when properly loaded on the platform engages the third knuckle to force the position indicator down the third distance to the other of the third and fourth positions.
In yet a further form, the third distance is greater than the second distance and the second distance is greater than the first distance.
In yet another further form, the sensor comprises first and second proximity sensors and the position indicator (a) is spaced from the proximity sensors in the first position, (b) is proximate the first proximity sensor and is spaced from the second proximity sensor in the second position, (c) is proximate both the first and second proximity sensors in the third position, and (d) is spaced from the first proximity sensor and proximate the second proximity sensor in the fourth position. In a further form, the proximity sensors are electric eyes, and the ears are detected as proximate thereto when the electric eyes are blocked.
In another aspect of the present invention, a carrier is provided which is usable in a biological testing system having a transporter adapted to move the carrier between a loading platform and an active storage carousel. The carrier includes a base member adapted to be received on the loading platform for loading the carrier into the testing system, at least one bottle seat rotatably mountable on one end of a pivot shaft through the base member, where the bottle seat is adapted to securely seat a container for a reagent usable in biological testing, and a drive member secured beneath the base member to the other end of the pivot shaft, wherein the drive member and bottle seat rotate together.
In one form of this aspect of the invention, the drive member is a gear.
In still another aspect of the present invention, a supply mechanism for a biological testing system is provided, including a loading platform, a carrier, a bar code reader, and a transporter. The carrier has a base member adapted to be received on the loading platform for loading the carrier into the testing system, at least one bottle seat rotatably mountable on one end of a pivot shaft through the base member, where the bottle seat is adapted to securely seat a container for a reagent usable in biological testing, and a drive member secured beneath the base member to the other end of the pivot shaft, wherein the drive member and bottle seat rotate together. The transporter is adapted to pick up the carrier at the loading platform and move the carrier to the bar code reader for reading a bar code identifying the reagent bottle seated on the one bottle seat. A drive adjacent the bar code reader is adapted to engage the carrier drive member when the reagent bottle seated on the one bottle seat is in position for its identifying bar code to be read by the bar code reader.
In yet another aspect of the present invention, a supply mechanism for a biological testing system is provided, including a storage carousel rotatably drivable about an axis, the carousel having storage locations therearound generally radially oriented relative to the axis, a plurality of carriers releasably securable on selected carousel storage locations, and a ring gear substantially centered on the axis. Each of the carriers has a base member adapted to be received on the loading platform for loading the carrier into the testing system, at least one bottle seat rotatably mountable on one end of a pivot shaft through the base member, the at least one bottle seat adapted to securely seat a container for a reagent usable in biological testing, and a drive member secured beneath the base member to the other end of the pivot shaft, wherein the drive member and at least one bottle seat rotate together. The ring gear engages the drive members of carriers secured to the carousel whereby rotation of the carousel about the axis rotates the bottle seat seats about the pivot shafts of the carriers to agitate reagent in seated containers.
In still another aspect of the present invention, a supply mechanism for a biological testing system is provided, including a storage carousel rotatably drivable about an axis, the carousel having storage locations therearound generally radially oriented relative to the axis, a plurality of carriers releasably securable on carousel storage locations, a transporter adapted to transport carriers to and from the carousel storage location located at a transfer station, a connector at each of the carousel storage locations for connecting the carriers to the carousel, and a release control adjacent the transfer station adapted to release the connection when the transporter is adjacent the transfer station.
In one form of this aspect of the present invention, the connector includes at least one pocket at each carousel storage location adapted to receive a tab on a loaded carrier to secure the carrier to the storage location, and a connecting member at each carousel storage location. The connecting member is biased in a first direction toward moving a carrier located in the carousel storage location to a position in which its tab is received in the pocket. The release control is engaged by the transporter to move the connecting member in a direction opposite the first direction to free the tab from the pocket when the transporter is adjacent the transfer station. In a further form, the release control is a lever actuated by the transporter to engage and move the connecting member of the storage location at the transfer station in the opposite direction. In another further form, a spring biases the connecting members in the first direction.
In another form of this aspect of the present invention, a bar code reader and a loading platform are provided. In this form, each of the carriers have a base member adapted to be received on the loading platform for loading the carrier into the testing system, at least one bottle seat rotatably mountable on one end of a pivot shaft through the base member, the bottle seat adapted to securely seat a container for a reagent usable in biological testing, and a drive member secured beneath the base member to the other end of the pivot shaft, wherein the drive member and bottle seat rotate together. Further, the transporter is adapted to pick up the carrier at the loading platform and move the carrier to the bar code reader for reading a bar code identifying the reagent bottle seated on the at least one bottle seat. This form further includes a ring gear substantially centered on the carousel axis, and a drive adjacent the bar code reader. The ring gear engages the drive members of carriers secured to the carousel whereby rotation of the carousel about the axis rotates the bottle seats about the pivot shafts of the carriers to agitate reagent in seated containers. Further, the drive adjacent the bar code reader is adapted to engage the carrier drive member when the reagent bottle seated on the one bottle seat is in position for its identifying bar code to be read by the bar code reader.
A testing system 20 such as may be used in biological testing of samples is shown in part in
The various features of the handling device 22 of the present invention are variously provided in a load platform 30, a reagent carousel 34, a transporter or transport carrier 38, reagent carriers 40, and sample carriers 42.
As a brief overview, an operator loads samples into suitable bottles or containers secured to the sample carriers 42 and/or loads reagents into suitable bottles or containers secured to the reagent carriers 40, and then places the loaded carrier (40 and/or 42) onto the load platform 30. (It should be appreciated that while the description herein illustrates containers which are separate from, and carried by, carriers 40, 42, single components which are integral carrier and containers could be advantageously used within the scope of many aspects of the present invention. That is, it could be within the scope of the present invention to provide containers which themselves are configured to be suitably handled as described herein, and it is not required that the function of the containers and carriers be provided by separate components.)
As described in detail below, the handling device 22 recognizes what type of carrier 40, 42 is loaded, and whether it has been properly loaded. When a properly loaded carrier 40, 42 is detected, it is automatically picked up by the transporter 38 and moved to a suitable bar code reader 46 which reads the bar codes on the containers and/or carriers 40, 42 to input such data into a control for the system 20 (e.g., a computer terminal allowing for operator input to control the system 20 for performing desired actions, such as is known in the art).
When the carrier is a sample carrier 42, the transporter 38 may then return the carrier to the load platform 30, or place it in a ready position for accessing by the testing system 20.
When the carrier is a reagent carrier 40, a motor drive 48 adjacent the bar code reader 46 is engaged to cause a selected one of the reagent containers to rotate to facilitate reading of its bar code by the bar code reader 46. The reagent carrier 40 (with its contents thus identified for the system 20) is then carried by the transporter 38 to a ready storage location and mounting on the carousel 34 located therein. As illustrated in
Testing by the testing system 20 may be accomplished by any suitable means which picks up the particular required samples and reagents (e.g., by a pipettor or other aspiration system which draws the samples and reagents from their containers) and then moves the samples and reagents to the testing area, where they are, for example, added to suitable reaction vessels which are processed as appropriate for the particular test desired. Any such testing system 20 may be advantageously used with the present invention, and details of such system 20 do not form a part of the present invention.
Reference will now be had to particular components of the present invention.
The load platform 30 is seen in
The load platform 30 may advantageously cooperate with the carriers 40, 42 to automatically detect the presence or absence of a carrier 40, 42 at a particular location 54, the type of carrier 40, 42 and whether the operator has manually loaded the carrier 40, 42 properly in the location. Specifically, a position indicator 60 is provided at each location 54 for detecting the position of anything placed in the associated location 54. A structure which may be advantageously used for this purpose in connection with the present invention is best illustrated in
The position indicator 60 is pivotally secured to the underside of the load platform 30 near the rear of each location 54, and a suitable spring 62 biases the position indicator 60 up against the bottom of the load platform 30. Openings are provided in the platform 30 through which projecting portions or knuckles 64, 66, 68 of the position indicator 60 project as best seen in
Raised ledges 70 are provided on opposite sides of each platform location 54, and the bottom of the reagent and sample carriers 40, 42 are differently configured whereby the bottom of the sample carriers 42 are narrower than the spacing between the ledges 70 so that they will rest on the bottom 72 of the platform location when properly loaded therein (see
Moreover, one set of knuckles 64 is located forwardmost of the platform 30, projecting above a raised front portion 76 of the platform a selected amount. It should be appreciated that a carrier 40, 42 which is not pushed into the location 54 sufficiently so as to be past the raised front portion 76 will rest on the knuckles 64 and push the position indicator 60 down that selected amount.
The second set of knuckles 66 is positioned rearwardly of the platform raised front portion 76 and extends above the platform location bottom 72 by a different selected amount. These knuckles 66 are spaced from the rear of the platform location 54 a distance substantially equal to the depth of a sample carrier 42. Accordingly, when a sample carrier 42 is properly loaded in the position 54 (resting on the platform location bottom 72), it will be past the raised front portion 76 and rest on the second set of knuckles 66 (between the side walls 66 a), thereby pushing the position indicator 60 down against the bias of the spring 62 that different selected amount.
The third set of knuckles 68 extend upwardly through openings in the raised ledges 70. The third set of knuckles 68 are spaced still further back from the platform front and, when a reagent carrier 40 is properly loaded in the platform location 54, it will rest on these knuckles 68 to push the position indicator 60 down against the bias of the spring 62 yet another selected amount. Still further, it should be appreciated that if the reagent carrier 40 is not sufficiently pushed into the platform location 54, it may rest either on the first set of knuckles 66, or on the side walls 66 a of the second set of knuckles 66, or (as illustrated in
It should be appreciated that the selected distances which the position indicator 60 may be pushed down in different conditions may be different from the particular described embodiment herein. Further, it should be understood that where the position indicator 60 is pivoted at one end as in the illustrated embodiment, the distance which a particular set of knuckles projects up to provide a particular displacement at the opposite end of the position indicator 60 will be dependent upon the distance of the knuckles from the pivot axis. In short, it should be understood that the relative positions and distances as illustrated for the knuckles 64, 66, 66 a, 68 of the illustrated embodiment could readily be varied in accordance with the present invention.
Depending upon the type of carrier 40, 42 and its position in a location 54 of the platform 30, the position indicator 60 will be variously pushed down to different positions against the biasing force of the spring 62, and the particular position of the position indicator 60 can be automatically detected to determine that information, as best illustrated in
In the upper position of the position indicator 60, with no carrier 40, 42 present at the platform location as illustrated in
If a carrier 40, 42 is loaded but not fully inserted into the location 54, it will either rest on the first set of knuckles 64 or (with a further but not fully inserted reagent carrier 40) partially push down on the third set of knuckles 68 as illustrated in
If a sample carrier 42 is properly inserted into the location 54, it will rest on the second set of knuckles 66 (see
Finally, if a reagent carrier 40 is properly inserted into the location 54, it will rest on the third set of knuckles 68 (see
Status indicator lights 82, 84 (see
Once a carrier 40, 42 has been properly loaded and detected at a platform location 54, it may then be automatically handled by the handling device 22.
Specifically, the transporter 38 with a gripper device 86 such as illustrated particularly in FIG. 6 of U.S. Pat. No. 6,588,625 B2 is positioned for movement behind the load platform 30. (The full disclosure of U.S. Pat. No. 6,588,625 B2 is hereby incorporated by reference.) The transporter 38 may, for example, be moved from a base position by a suitable drive such as a stepper motor to align its gripper device 86 with a support tab 88 (see, e.g.,
More particularly, in
The reagent containers 94 a-94 c may be advantageously secured to the carrier 40 by bottle seats 95 or other suitable retention structures (e.g., retention tabs) to securely hold the containers 94 a-94 c thereon by, for example, friction or a snap-fit, depending upon the container 94 a-94 c. In accordance with one feature of the present invention, however, it should be appreciated that the container 94 a should be secured relative to its bottle seat 95 so that it will rotate therewith.
As described in further detail hereinafter, at least one of the reagent containers 94 a may be suitably secured to the carrier 40 so as to pivot with a drive gear 98 which is positioned on the bottom side of the reagent carrier 40. When that container 94 a is positioned adjacent the bar code reader 46 for reading of its bar code (see
This provides for particularly reliable bar code reading for containers (i.e., containers 94 a containing reagents with microparticles) which may otherwise be difficult to read, as it ensures that the bar code 96 will at some point be properly oriented relative to the bar code reader 46 for proper reading. For example, shorter containers, which may require that the bar code 96 be wrapped around a cylindrical container rather than extending the height of the container 94, can advantageously be read in this manner. In fact, it should be appreciated that while the figures illustrate container 94 a as being generally the same height at the other reagent containers 94 b-94 c, the container 94 a, which is subject to being rotated, can advantageously be of a lesser height than those other containers 94 b-94 c, allowing not only for compact size where reagent containers 94 a-94 c advantageously store different reagent quantities (based, e.g., on testing requirements), but also allowing for a uniform top of all carried containers 94 a-94 c.
While the drive gear 98 may be a pinion type gear as discussed further hereinafter, the motor drive 48 adjacent the bar code reader 46 need not mesh with the gear teeth, but instead may advantageously consist of a resilient tapered disk, such as a conical rubber disk, which may be brought into frictional engagement with the bottom outer edge of the gear 98 (e.g., by lowering the carrier 40 a onto the conical rubber disk when the carrier 40 is present for reading the bar code 96 of that container 94 a). Such a drive 48 may thereby suitably engage the gear 98 to cause the desired rotation while the container 94 a is being read.
At this point, the computer control for the handling device 22 will have the identity of each reagent container 94 a-94 c, and the reagent carrier 40 a may then move clear of the bar code reader 46 and pivot as indicated by arrows 90 e and 90 e′ in
Movement of the sample carriers 42 from the platform 30 to the bar code reader 46 can be accomplished similar to the movement illustrated in
As illustrated in
Reference will now be had to
The carousel 34 is illustrated in
An annular gear 124 (see
Various reagent carriers 40 are secured to the carousel 34 at selected or known support locations. Loading of such carriers 40 may be accomplished first in accordance with the sequence illustrated in
The housing port 140 is aligned with the carousel carrier support location, which is located at a specific position within the housing 50. Specifically, a magnetic proximity detector 142 is fixed inside the housing 50 at that position as described in greater detail hereinafter.
A ring gear 146 is fixedly mounted concentric with the axis of rotation of the carousel 34 to pivot the reagent containers 94 a as further detailed herein.
As illustrated in
As best illustrated in
Reference will now be had specifically to
Specifically, the transporter 38 moves the carrier 40 after reading by the bar code reader 46 from the position shown in
When the transporter 38 leaves the area of the housing port 140, the release control 180 is no longer forced to pull on the slide member bottom ear 164, and therefore the slide member 160 is biased by its spring 162 to slide radially inwardly (toward the axis of the carousel 34). When this occurs, the slide member 160 through the engagement of its top ear 166 with the carrier recess 190 pulls the carrier 40 with it, and tabs 192 on the bottom of the carrier 40 are received in the pockets defined by the connector raised portions 154 to secure the carrier 40 to the carousel 34.
It should be appreciated that removal of a reagent carrier 40 may be conveniently and advantageously accomplished in a reverse order. Specifically, the transporter 38 can approach the housing port 140, engaging the release control 180 to pull the slide member 160 radially outwardly, and thereby also pull the carrier 40 (via the engagement of the top ear 166 with the carrier recess 190) outwardly, whereby the tabs 192 are out of the pockets defined by the connector 150. In that position, the carrier 40 essentially rests freely on the carousel 34 and may be picked up and removed therefrom by the transporter gripper device 186. The transporter 38 may then return the carrier 40 to the load platform 30, from which an operator may manually remove the carrier and either refill or replace the containers 94 a-94 c if appropriate.
Moreover, as illustrated in
When loaded, it should be appreciated that the carousel 34 will carry containers 94 a-94 c in three concentric rings about its central axis. The refrigerated compartment housing 50 may advantageously include three openings 220 (see
It should be appreciated from the above description that the present invention may be used to provide particularly advantageous handling of reagents and samples in automatic testing systems.
Still other aspects, objects, and advantages of the present invention can be obtained from a study of the specification, the drawings, and the appended claims. It should be understood, however, that the present invention could be used in alternate forms where less than all of the objects and advantages of the present invention and preferred embodiment as described above would be obtained.
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|U.S. Classification||422/63, 422/561|
|Cooperative Classification||Y10T436/11, Y10S901/01, G01N2035/00891, G01N35/025, G01N35/0099, G01N35/00722, G01N35/00712, G01N2035/0443, G01N2035/00752|
|Mar 31, 2006||AS||Assignment|
Owner name: ABBOTT LABORATORIES, ILLINOIS
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:GOMM, CORDELL K.;LUOMA II, ROBERT P.;ARNQUIST, DAVID CHARLES;AND OTHERS;REEL/FRAME:017419/0712
Effective date: 20050825
|Mar 18, 2013||FPAY||Fee payment|
Year of fee payment: 4
|May 25, 2017||FPAY||Fee payment|
Year of fee payment: 8