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Publication numberUS7854734 B2
Publication typeGrant
Application numberUS 11/458,074
Publication dateDec 21, 2010
Filing dateJul 17, 2006
Priority dateOct 17, 2000
Fee statusPaid
Also published asUS7104987, US7837679, US8888769, US20040010289, US20060247726, US20060247727, US20110172655, US20150038959
Publication number11458074, 458074, US 7854734 B2, US 7854734B2, US-B2-7854734, US7854734 B2, US7854734B2
InventorsMichael Biggs, Roger A. Stern, Christopher J. Danek
Original AssigneeAsthmatx, Inc.
Export CitationBiBTeX, EndNote, RefMan
External Links: USPTO, USPTO Assignment, Espacenet
Control system and process for application of energy to airway walls and other mediums
US 7854734 B2
Abstract
The present invention includes a system for delivering energy to an airway wall of a lung comprising an energy delivering apparatus and a PID controller having one or more variable gain factors which are rest after energy deliver has begun. The energy delivering apparatus may include a flexible elongated member and a distal expandable basket having at least one electrode for transferring energy to the airway wall and at least one temperature sensor for measuring temperature. The PID controller determines a new power set point base on an error between a preset temperature and the measured temperature. The algorithm can be Pi+1=Pi+G(αei+βei−1+γei−2) where α, β and γ are preset values and α is from 1 to 2; β is from −1 to −2; and γ is from −0.5 to 0-5. In another variation, the controller is configured to shut down if various measured parameters are exceeded such as, for example, energy, impedance, temperature, temperature differences, activation time and combinations thereof. Methods for treating a target medium using a PID algorithm are also provided.
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Claims(50)
1. A system for delivering energy to an airway wall of a lung comprising:
an energy delivering apparatus comprising a flexible elongated member and a distal expandable basket, said expandable basket having at least one electrode for transferring energy to said airway wall and at least one temperature sensor for measuring temperature (TM) of said airway wall when energy is delivered to said airway wall; and
a PID controller for determining a new power set point (Pi+1) based on an error (e) between a preset temperature (TS) and said measured temperature (TM) wherein said PID controller applies an algorithm having a variable gain factor (G), wherein the controller includes instructions that cause the controller to terminate the power when the measured temperature TM decreases by about more then 10 C. in a sample period.
2. The system of claim 1 wherein said controller is configured such that G is reset 0.1 to 2 seconds after energy delivery has begun.
3. The system of claim 2 wherein said controller is configured such that G is reset 0.5 seconds after energy delivery has begun.
4. The system of claim 3 wherein said controller is configured such that G is reset to 0.9 to 1.0 if a temperature rise in C. per Joule is less than or equal to 2.5.
5. The system of claim 3 wherein said controller is configured such that G is reset to 0.4 to 0.5 if a temperature rise in C. per Joule is between 2.5 to 5.0.
6. The system of claim 3 wherein said controller is configured such that G is reset to 0.2 to 0.3 if a temperature rise in C. per Joule is equal to 5.0 to 7.5.
7. The system of claim 3 wherein said controller is configured such that G is reset to 0.1 to 0.2 if a temperature rise in C. per Joule is greater than 7.5.
8. The system of claim 1 wherein said algorithm further includes a PID algorithm:
Pi+1=Pi+G(αei+βei−1+γei−2) where α, β and γ are preset values.
9. The system of claim 8 wherein α is from 1 to 2.
10. The system of claim 9 wherein β is from −1 to −2.
11. The system of claim 10 wherein γ is from −0.5 to 0.5.
12. The system of claim 11 wherein α, β, γ are 1.6, −1.6, and 0.0 respectively.
13. The system of claim 1 wherein said controller is configured such that said energy delivery is tetininated if said energy delivered exceeds a maximum energy.
14. The system of claim 13 wherein said maximum energy is 120 joules.
15. The system of claim 1 wherein said controller is configured to deliver energy for an activation time period.
16. The system of claim 15 wherein said controller is configured such that the activation time period is up to 15 seconds.
17. The system of claim 16 wherein said controller is configured such that the activation time period is 8 to 12 seconds.
18. The system of claim 17 wherein said controller is configured such that the activation time period is 10 seconds.
19. The system of claim 1 wherein said controller is configured such that TS is set at a value between 60 to 80 C.
20. The system of claim 19 wherein TS is set at 65 C.
21. The system of claim 1 wherein said controller is configured to measure impedance and said energy delivery is terminated when said impedance drops below a preset impedance value.
22. The system of claim 21 wherein said preset impedance value is 40 to 60 ohms.
23. The system of claim 1 wherein said controller is configured to terminate said energy delivery if said TM exceeds TS by a pre-selected value.
24. The system of claim 23 wherein said pre-selected value is 10 C.
25. The system of claim 23 wherein said pre-selected value is 15 C.
26. The system of claim 23 wherein said pre-selected value is 20 C.
27. The system of claim 1 wherein a nominal output power of the energy delivered is set at a value of at least 17 watts.
28. The system of claim 27 wherein said sampling period is set at a value of at least 0.5 seconds.
29. The system of claim 28 wherein said critical temperature difference is 2 C.
30. The system of claim 1 further comprising terminating the energy delivery if the TM averaged over a time window exceeds TS by a fixed temperature difference.
31. The system of claim 30 wherein said fixed temperature difference is 5 C.
32. The system of claim 31 wherein said time window is between 1 and 5 seconds.
33. The system of claim 32 wherein said time window is 2 seconds.
34. The system of claim 1 wherein the sample period is 1.0 seconds.
35. The system of claim 1 wherein the sample period is 0.2 seconds.
36. The system of claim 1 wherein the gain factor is initially equal to a value between 0.4 and 0.5.
37. The system of claim 1 wherein said PID controller applies an algorithm having a plurality of variable gain factors.
38. The system of claim 37 wherein said algorithm is Pi+1=+(G1ei+G2ei−1+G3ei−2) where G1, G2 and G3 are variable gain factors.
39. The system of claim 38 wherein said controller is configured such that said variable gain factors are reset 0.1 to 2 seconds after energy delivery has begun.
40. The system of claim 39 wherein said controller is configured such that said variable gain factors are reset 0.5 seconds after energy delivery has begun.
41. The system of claim 40 wherein said controller is configured such that G1, G2 and G3 are reset to 0.90 to 2.00, −0.90 to −2.00 and 0.5 to −0.5 respectively if a temperature rise in C. per Joule is less than or equal to 2.5.
42. The system of claim 40 wherein said controller is configured such that G1, G2 and G3 are reset to 0.40 to 1.00, −0.40 to −1.00 and 0.25 to −0.25 respectively if a temperature rise in C. per Joule is between 2.5 to 5.0.
43. The system of claim 40 wherein said controller is configured such that G1, G2 and G3 are reset to 0.20 to 0.60, −0.20 to −0.60 and 0.15 to −0.15 respectively if a temperature rise in C. per Joule is equal to 5.0 to 7.5.
44. The system of claim 40 wherein said controller is configured such that G1, G2 and G3 are reset to 0.10 to 0.40, −0.10 to −0.40 and 0.10 to −0.10 respectively if a temperature rise in C. per Joule is greater than 7.5.
45. The system of claim 38 wherein each of said variable gain factors is equal to a product of at least one preset value and at least one variable value.
46. The system of claim 1 wherein the energy delivery apparatus is configured to deliver an amount of power up to a maximum power.
47. The system of claim 46 wherein the maximum power is 10 to 40 watts.
48. The system of claim 47 wherein the maximum power is 15 to 20 watts.
49. A system for delivering energy to an airway wall of a lung comprising:
an energy delivering apparatus comprising a flexible elongated member and a distal expandable basket, said expandable basket having at least one electrode for transferring energy to said airway wall and at least one temperature sensor for measuring temperature (TM) of said airway wall when energy is delivered to said airway wall; and
a PID controller for determining a new power set point (Pi+1) based on an error (e) between a preset temperature (TS) and said measured temperature (TM) wherein said PID controller applies an algorithm having a variable gain factor (G), wherein the controller includes instructions that cause the controller to terminate the power when the power exceeds 15-20 W and the temperature decreases by about more the 2 C. over a sampling period of about 0.1 to 1.0 second.
50. The system of claim 49 wherein the controller includes instructions that cause the controller to terminate power when the power exceeds about 17 W.
Description
CROSS REFERENCE TO RELATED APPLICATIONS

This application is a continuation of U.S. patent application Ser. No. 10/414,411 filed Apr. 14, 2003, now U.S. Pat. No. 7,104,987, which is a continuation of International Patent Application No. PCT/US01/32321 filed Oct. 17, 2001 and is a continuation-in-part of International Patent Application No. PCT/US00/28745 filed Oct. 17, 2000, the contents of which are hereby incorporated in their entirety.

FIELD OF THE INVENTION

This invention is related to systems for applying energy to lung airways and in particular, to a system and method for controlling the energy delivered to the airways using a PID algorithm to minimize error between a preset temperature and a measured temperature.

BACKGROUND

Various obstructive airway diseases have some reversible component. Examples include COPD and asthma. There are an estimated 10 million Americans afflicted with Asthma. Asthma is a disease in which bronchoconstriction, excessive mucus production, and inflammation and swelling of airways occur, causing widespread but variable airflow obstruction thereby making it difficult for the asthma sufferer to breathe. Asthma is a chronic disorder, primarily characterized by persistent airway inflammation. Asthma is further characterized by acute episodes of additional airway narrowing via contraction of hyper-responsive airway smooth muscle.

Reversible aspects of obstructive pulmonary disease generally include excessive mucus production in the bronchial tree. Usually, there is a general increase in bulk (hypertrophy) of the large bronchi and chronic inflammatory changes in the small airways. Excessive amounts of mucus are found in the airways and semisolid plugs of mucus may occlude some small bronchi. Also, the small airways are narrowed and show inflammatory changes. Reversible aspects include partial airway occlusion by excess secretions and airway narrowing secondary to smooth muscle contraction, bronchial wall edema and inflammation of the airways.

In asthma, chronic inflammatory processes in the airway play a central role in increasing the resistance to airflow within the lungs. Many cells and cellular elements are involved in the inflammatory process, particularly mast cells, eosinophils T lymphocytes, neutrophils, epithelial cells, and even airway smooth muscle itself. The reactions of these cells result in an associated increase in the existing sensitivity and hyper-responsiveness of the airway smooth muscle cells that line the airways to the particular stimuli involved.

The chronic nature of asthma can also lead to remodeling of the airway wall (i.e., structural changes such as thickening or edema) which can further affect the function of the airway wall and influence airway hyper-responsiveness. Other physiologic changes associated with asthma include excess mucus production, and if the asthma is severe, mucus plugging, as well as ongoing epithelial denudation and repair. Epithelial denudation exposes the underlying tissue to substances that would not normally come in contact with them, further reinforcing the cycle of cellular damage and inflammatory response.

In susceptible individuals, asthma symptoms include recurrent episodes of shortness of breath (dyspnea), wheezing, chest tightness, and cough. Currently, asthma is managed by a combination of stimulus avoidance and pharmacology.

Stimulus avoidance is accomplished via systematic identification and minimization of contact with each type of stimuli. It may, however, be impractical and not always helpful to avoid all potential stimuli.

Pharmacological management of asthma includes: (1) long term control through use of anti-inflammatories and long-acting bronchodilators and (2) short term management of acute exacerbations through use of short-acting bronchodilators. Both of these approaches require repeated and regular use of the prescribed drugs. High doses of corticosteroid anti-inflammatory drugs can have serious side effects that require careful management. In addition, some patients are resistant to steroid treatment. The difficulty involved in patient compliance with pharmacologic management and the difficulty of avoiding stimulus that triggers asthma are common barriers to successful asthma management. Current management techniques are thus neither completely successful nor free from side effects. Accordingly, it would be desirable to provide a system and method which improves airflow without the need for patient compliance.

Various energy delivering systems have been developed to intraluminally treat anatomical structures and lumen other than the lung airways. Unfortunately, the systems which are useful in treating such structures are generally not helpful in developing techniques to treat the lung airways because the lung airways are markedly different than other tissue structures. For example, lung airways are particularly heterogeneous. Variations in lung tissue structure occur for a number of reasons such as: the branching pattern of the tracheobronchial tree leads to local variation in the size and presence of airways; the vasculature of the lungs is a similar distributed network causing variation in size and presence of blood vessels; within the airways are variable amounts of differing structures such as cartilage, airway smooth muscle, and mucus glands and ducts; and energy delivery may also be influenced differently at the periphery, near the outer surface of a lung lobe, than in the central portion.

Lung airways also include a number of protruding folds. Other tissue structures such as blood vessels typically do not have the folds found in airways. Airways contain mucous and air whereas other structures contain different substances. The tissue chemistry between various lumens and airways is also different. In view of these differences, it is not surprising that conventional energy delivering systems cannot be universally applied to treat all tissue structures. Moreover, power shut-offs and other safety mechanisms must be precisely tailored to specific tissue so that the tissue is not harmed by application of excess energy.

Accordingly, an intraluminal RF energy delivering system that is capable of safely delivering RF energy to lung airways is desired. In particular, a system which is capable of controlling the temperature when treating an airway of an asthma or COPD patient is desired. It is also desirable to provide a system having built-in safeguards that shut the power off thereby preventing damage to the subject tissue or collateral tissue.

SUMMARY OF THE INVENTION

The present invention includes a system for delivering energy to an airway wall of a lung comprising an energy delivering apparatus and a PID controller. The energy delivering apparatus may include a flexible elongated member and a distal expandable basket having at least one electrode for transferring energy to the airway wall and at least one temperature sensor for measuring temperature (TM) of the airway wall when energy is delivered to the airway wall. The system further comprises a PID controller for determining a new power set point (Pi+1) based on an error (e) between a preset temperature (TS) and the measured temperature wherein the PID controller applies an algorithm having a variable gain factor (G).

In one variation of the present invention, the algorithm is Pi+1=Pi+G(αei+βei−1+γei−2) where α, β and γ are preset values. For instance, in one variation of the present invention, α is from 1 to 2; β is from −1 to −2; and γ is from −0.5 to 0.5. In another variation of the present invention, α, β, γ are 1.6, −1.6, and 0.0 respectively.

In another variation of the present invention, the gain factor used in the PID algorithm is reset 0.1 to 2 seconds after energy delivery has begun. The gain factor can also be reset 0.5 seconds after energy delivery has begun. The invention includes resetting G to 0.9 to 1.0 if a temperature rise in C. per Joule is less than or equal to 2.5; 0.4 to 0.5 if a temperature rise in C. per Joule is between 2.5 to 5.0; to 0.2 to 0.3 if a temperature rise in C. per Joule is equal to 5.0 to 7.5; and to 0.1 to 0.2 if a temperature rise in C. per Joule is greater than 7.5. Initially, the gain factor is equal to 0.4 to 0.5 and preferably 0.45 to 0.47.

In another variation of the present invention, the PID algorithm is Pi+1=Pi+(G1ei+G2ei−1+G3ei−2) and G1, G2 and G3 are variable gain factors. The invention includes configuring the controller such that G1, G2 and G3 are reset to 0.9 to 2.00, −0.9 to −2.00 and 0.5 to −0.5 respectively if a temperature rise in C. per Joule is less than or equal to 2.5; to 0.40 to 1.00, −0.40 to −1.00 and 0.25 to −0.25 respectively if a temperature rise in C. per Joule is between 2.5 to 5.0; to 0.20 to 0.60, −0.20 to −0.60 and 0.15 to −0.15 respectively if a temperature rise in C. per Joule is equal to 5.0 to 7.5; and to 0.10 to 0.40, −0.10 to −0.40 and 0.10 to −0.10 respectively if a temperature rise in C. per Joule is greater than 7.5. Each of the variable gain factors may be equal to a product of at least one preset value and at least one variable value.

In another variation of the present invention, the controller is configured such that the energy delivery is terminated if the energy delivered exceeds a maximum energy such as 120 joules.

In another variation of the present invention, the controller is configured to deliver energy for an activation time period such as up to 15 seconds, 8 to 12 seconds, or 10 seconds.

In another variation of the present invention, the controller is configured such that TS is set at a value between 60 to 80 C., or 65 C.

In another variation of the present invention, the controller is configured to measure impedance and said energy delivery is terminated when said impedance drops below a preset impedance value such as 40 to 60 ohms.

In another variation of the present invention, the controller is configured to terminate the energy delivery if TM exceeds TS by a pre-selected value such as 10, 15 or 20 C.

In another variation of the present invention, the controller is configured to terminate the energy delivery if the output power is greater or equal to a nominal output power and TM drops by a critical temperature difference within a sampling period. The invention includes a nominal output power set at a value of at least 17 watts; the sampling period is set at a value of at least 0.5 seconds; and the critical temperature difference is 2 C.

In another variation of the present invention, the controller is configured to terminate the energy delivery if said TM averaged over a time window exceeds TS by a fixed temperature difference. The fixed temperature difference may be a value between 1 and 10 C. or 5 C. The time window is between 1 and 5 seconds or 2 seconds.

In another variation of the present invention, the controller is configured to terminate if the measured temperature drops by 10 or more C. in a sample period such as 1.0 seconds or 0.2 seconds.

Another variation of the present invention is a method for treating a lung by transferring energy from an active region of an energy delivery apparatus to an airway wall of the lung. The energy delivery apparatus includes a flexible elongate body and a distal section and the active region is located in the distal section. The energy delivery apparatus further has a temperature sensor located in the distal section for measuring a temperature (TM) of said airway wall and the method comprises the following steps: setting a preset temperature (TS); determining a power set point (Pi) to deliver energy from the active region to the target medium; measuring the TM using the temperature sensor; and determining a new power set point (Pi+1) based on an error (e) between the preset temperature (TS) and the measured temperature (TM) using a PID algorithm.

In yet another variation of the present invention, a process for transferring energy to a target medium using an energy delivery apparatus is provided. The energy delivery apparatus includes a flexible elongate body and a distal section wherein the distal section includes an expandable basket with at least one active region for transferring energy to the target medium. The energy delivery apparatus further has a temperature sensor located in the distal section for measuring a temperature (TM) of the target medium. The process comprises the following steps: setting a preset temperature (TS); determining a power set point (Pi) to deliver energy from the active region to the target medium; measuring TM using the temperature sensor; and determining a new power set point (Pi+1) based on an error (e) between the preset temperature (TS) and the measured temperature (TM) using an algorithm having a variable gain factor. The energy may be delivered to an airway wall of a lung in vivo, in vitro or to another target such as a sponge or towel which may be moistened with saline solution. Saline solution increases the conductivity of the target.

In one variation of the present invention, the algorithm is Pi+1=Pi+G(αei+βei−1+γei−2) where α, β and γ are preset values: α is from 1 to 2; β is from −1 to −2; and γ is from −0.5 to 0.5. In another variation of the present invention, α, β, γ are 1.6, −1.6, and 0.0 respectively.

In another variation of the present invention, the gain factor is reset 0.1 to 2 seconds after energy delivery has begun. The gain factor can also be reset 0.5 seconds after energy delivery has begun. The invention includes resetting G to 0.9 to 1.0 if a temperature rise in C. per Joule is less than or equal to 2.5; 0.4 to 0.5 if a temperature rise in C. per Joule is between 2.5 to 5.0; to 0.2 to 0.3 if a temperature rise in C. per Joule is equal to 5.0 to 7.5; and to 0.1 to 0.2 if a temperature rise in C. per Joule is greater than 7.5. Initially, the gain factor is equal to 0.4 to 0.5 and preferably 0.45 to 0.47.

In another variation of the present invention, the energy delivery is terminated if the energy delivered exceeds a maximum energy such as 120 joules.

In another variation of the present invention, energy is delivered for an activation time period such as 0 to 15 seconds, 8 to 12 seconds, or 10 seconds.

In another variation of the present invention, TS is set at a value between 60 to 80, or 65 C.

In another variation of the present invention, impedance is measured and energy delivery is terminated when the impedance drops below a preset impedance value such as 40 to 60 ohms.

In another variation of the present invention, the energy is terminated if TM exceeds TS by a pre-selected value such as 10, 15 or 20 C.

In another variation of the present invention, energy is terminated if the output power is greater or equal to a nominal output power and TM drops by a critical temperature difference within a sampling period. In variations of the present invention, the nominal output power is set at a value of at least 17 watts; the sampling period is set at a value of at least 0.5 seconds; and the critical temperature difference is 2 C.

In another variation, the energy delivery apparatus is configured to deliver an amount of power up to a maximum power. The maximum power can be from 10 to 40 watts and preferably from 15 to 20 watts.

In another variation of the present invention, energy delivery is terminated if TM averaged over a time window exceeds TS by a fixed temperature difference. The fixed temperature difference may be a value between 1 and 10 C. or 5 C. The time window is between 1 and 5 seconds or 2 seconds.

In another variation of the present invention, the energy delivery is terminated if the measured temperature drops by 10 or more C. in a sample period such as 1.0 seconds or 0.2 seconds.

BRIEF DESCRIPTION OF THE DRAWINGS

The invention will now be described in greater detail with reference to the various embodiments illustrated in the accompanying drawings:

FIG. 1 is a block diagram of a feedback loop of the present invention.

FIG. 2A is a cross sectional view of a medium sized bronchus in a healthy patient.

FIG. 2B is a cross sectional view of a bronchiole in a healthy patient.

FIG. 3 is a cross sectional view of the bronchus of FIG. 2A showing the remodeling and constriction occurring in an asthma patient.

FIG. 4 is an illustration of the lungs being treated with a device and controller according to the present invention.

FIG. 5A is an illustration of an energy delivery device in accordance with the present invention.

FIGS. 5B-5D show a partial view of a thermocouple attached to a basket leg in accordance with the present invention.

DETAILED DESCRIPTION

The present invention includes a controller and an energy deliver apparatus to deliver energy to the airway walls of the lungs. Amongst other features, the controller includes a feedback loop having a variable gain factor as diagramed in FIG. 1. The system is useful in treating asthma and various symptoms of reversible obstructive pulmonary disease. Examples of suitable applications and methods are disclosed in International Application No. PCT/IUS00/28745 filed Oct. 17, 2000.

The present invention is particularly useful in treating lung tissue. This is surprising in view of the unique and complicated structure of lung tissue. Referring first to FIG. 2A and 2B, a cross section of two different airways in a healthy patient is shown. The airway of FIG. 2A is a medium sized bronchus having an airway diameter D1 of about 3 mm. FIG. 2B shows a section through a bronchiole having an airway diameter D2 of about 1.5 mm. Each airway includes a folded inner surface or epithelium 10 surrounded by stroma 12 and smooth muscle tissue 14. The larger airways including the bronchus shown in FIG. 2A also have mucous glands 16 and cartilage 18 surrounding the smooth muscle tissue 14. Nerve fibers 20 and blood vessels 24 surround the airway. The airway is thus quite different from other tissues such as blood vessel tissue which does not include such folds, cartilage or mucous glands. In contrast, FIG. 3 illustrates the bronchus of FIG. 2A in which the smooth muscle 14 has hypertrophied and increased in thickness causing the airway diameter to be reduced from the diameter D1 to a diameter D3. Accordingly, the airways to be treated with the device of the present invention may be 1 mm in diameter or greater, more preferably 3 mm in diameter or greater.

FIG. 4 is an illustration of the lungs being treated with a system 36 according to the present invention. The system 36 includes a controller 32 and an energy treatment device 30 which may be an elongated member as described further below. The device 30 also includes an expandable distal section which can be positioned at a treatment site 34 within a lung or another target medium. In operation, the device is manipulated to the treatment site 34. RF energy, for example, is delivered through the energy delivering device and penetrates the surface of the lung tissue such that tissue is affected below the epithelial layer as well as on the surface of the lung tissue.

Energy Delivering Device

As indicated above, the present invention includes a controller 32 and a device 30 through which it delivers energy to the target medium 34. A device 30 of the present invention should be of a size to access the bronchus or bronchioles of the human lung. The device may be sized to fit within bronchoscopes, preferably, with bronchoscopes having a working channel of 2 mm or less. The device may also include a steering member configured to guide the device to a desired target location. For example, this steering member may deflect a distal tip of the device in a desired direction to navigate to a desired bronchi or bronchiole.

The energy delivering apparatus 30 typically includes an elongate body having a proximal section and a distal section. The distal section features a radially expandable basket having a plurality of legs. The legs may be electrodes or have an active region defined by an insulated covering which contacts the medium to be treated. The basket is expanded with an actuator mechanism which may be provided in a handle attached to proximal end of the elongate body. Examples of energy delivering devices in accordance with the present invention are described in co-pending U.S. application Ser. No. 09/436,455 filed Nov. 8, 1999 which is hereby incorporated by reference in its entirety.

Temperature Sensor

The invention also includes a temperature detecting element. Examples of temperature detecting elements include thermocouples, infrared sensors, thermistors, resistance temperature detectors (RTDs), or any other apparatus capable of detecting temperatures or changes in temperature. The temperature detecting element is preferably placed in proximity to the expandable member.

FIG. 5A is a partial view of a variation of the invention having thermocouple 137 positioned about midway along basket leg 106. FIG. 5B is an enlarged partial view of the thermocouple 137 of FIG. 5A showing the leads 139 separately coupled on an inwardly-facing surface of the leg 106. Consequently, the basket leg itself is used as part of the thermocouple junction upon which the temperature measurement is based. In other words, the thermocouple junction is intrinsic to the basket leg. This configuration is preferred because it provides an accurate temperature measurement of tissue contacting the leg 106 in the vicinity of the thermocouple leads. In contrast, typical thermocouple configurations consist of a thermocouple junction offset or extrinsic to the basket leg. We believe that thermocouple junctions having an offset from or extrinsic to the basket leg do not measure temperature as accurately in certain applications as thermocouple junctions which are intrinsic to the basket leg.

The leads 139 may be placed at other locations along the leg 106 including an edge 405. Joining the leads 139 to the edge 405, however, is undesirable because of its relatively small bonding surface.

FIG. 5B also shows basket leg 106 having an outer insulating material or coating 410. The boundaries 415 of the insulating material 410 define an uninsulated, active section of electrode leg 106 which delivers energy to the tissue walls. Preferably, the insulating coating 410 is heat shrink tubing or a polymeric coating. However, other insulating materials may be used.

FIGS. 5C and 5D show another variation of the present invention having thin foil or laminated thermocouple leads 139. The thermocouple leads 139 are configured as foils or layers which can be, for example, prefabricated foils or sputtered films. Suitable materials for the thermocouple leads (listed in pairs) include, but are not limited to: Constantan and Copper; Constantan and Nickel-Chromium; Constantan and Iron; and Nickel-Aluminum and Nickel-Chromium. The thermocouple pair, CHROMEL and ALUMEL (both of which are registered trademarks of Hoskins Manufacturing) is preferred. CHROMEL and ALUMEL is a standard thermocouple pair and has been shown to be biocompatible and corrosion resistant in our applications. The thermocouple leads 139 may be placed such that each lead approaches the center of the basket leg from an opposite end of the basket leg. The leads 139 then terminate in bond joints 440 and 450. Alternatively, as shown in the configuration of FIG. 5D, both thermocouple leads 139 may run from the same end of the basket leg 106.

Preferably, insulating layers 430 and 440 are disposed between the thin film leads 139 and the basket leg 106. The insulating layers 430 and 440 electrically separate the leads 139 as well as electrically separate the leads from the leg 106. The insulating layers 430 and 440 limit the thermocouple junction to bond joints 450 and 460, which are optimally positioned on active region 420 of basket leg 106.

Controller

The present invention includes a controller which controls the energy to be delivered to the airways via an energy transfer device. The controller includes at least one of the novel features disclosed hereinafter and may also incorporate features in known RF energy controllers. An example of a RF generator which may be modified in accordance with the present invention is the FORCET™ 2 Generator manufactured by Valleylab, Boulder, Colo., U.S.A. Another suitable technique to generate and control RF energy is to modulate RF output of a RF power amplifier by feeding it a suitable control signal.

The controller and power supply is configured to deliver enough energy to produce a desired effect in the lung. The power supply should also be configured to deliver the energy for a sufficient duration such that the effect persists. This is accomplished by a time setting which may be entered into the power supply memory by a user.

The power supply or generator of the present invention can also employ a number of algorithms to adjust energy delivery, to compensate for device failures (such as thermocouple detachment), to compensate for improper use (such as poor contact of the electrodes), and to compensate for tissue inhomogeneities which can affect energy delivery such as, for example, subsurface vessels, adjacent airways, or variations in connective tissue.

The power supply can also include circuitry for monitoring parameters of energy transfer: (for example, voltage, current, power, impedance, as well as temperature from the temperature sensing element), and use this information to control the amount of energy delivered. In the case of delivering RF energy, typical frequencies of the RF energy or RF power waveform are from 300 to 1750 kHz with 300 to 500 kHz or 450 to 475 being preferred. The RF power-level generally ranges from about 0-30 W but depends upon a number of factors such as, size of the electrodes. The controller may also be configured to independently and selectively apply energy to one or more of the basket leg electrodes.

A power supply may also include control modes for delivering energy safely and effectively. Energy may be delivered in open loop (power held constant) mode for a specific time duration. Energy may also be delivered in temperature control mode, with output power varied to maintain a certain temperature for a specific time duration. In the case of RF energy delivery via RF electrodes, the power supply may also operate in impedance control mode.

Temperature Control Mode

In a temperature control mode, the power supply may operate up to a 75 C. setting. That is, the temperature measured by the thermocouple can reach up to 75 C. before the power supply is shut off. The duration must be long enough to produce the desired effect, but as short as possible to allow treatment of all of the desired target airways within a lung. For example, up to 15 seconds is suitable, and more preferably 8 to 12 seconds with about 10 seconds per activation (while the device is stationary) being preferred. Shorter duration with higher temperature will also produce an acceptable acute effect.

It should be noted that different device constructions utilize different parameter settings to achieve the desired effect. For example, while direct RF electrodes typically utilize temperatures up to 75 C. in temperature control mode, resistively heated electrodes may utilize temperatures up to 90 C.

Energy Pulses and Energy Modulation

Short bursts or pulses of RF energy may also be delivered to the target tissue. Short pulses of RF energy heat the proximal tissue while the deeper tissue, which is primarily heated by conduction through the proximal tissue, cools between the bursts of energy. Short pulses of energy therefore tend to isolate treatment to the proximal tissue.

The application of short pulses of RF energy may be accomplished by modulating the RF power waveform with a modulation waveform. Modulating the RF power waveform may be performed while employing any of the other control algorithms discussed herein so long as they are not exclusive of one another. For example, the RF energy may be modulated while in a temperature control mode.

Examples of modulation waveforms include but are not limited to a pulse train of square waves, sinusoidal, or any other waveform types. In the case of square wave modulation, the modulated RF energy can be characterized in terms of a pulse width (the time of an individual pulse of RF energy) and a duty cycle (the percent of time the RF output is applied). A suitable duty cycle can be up to 100% which is essentially applying RF energy without modulation. Duty cycles up to 80% or up to 50% may also be suitable for limiting collateral damage or to localize the affect of the applied energy.

Feedback Algorithm

As indicated above, the present invention includes controllers having various algorithms. The algorithms may be either analog and digital based. A preferred embodiment is a three parameter controller, or Proportional-Integral-Derivative (PID) controller which employs the following algorithm: Pi+1=Pi+G(αei+βei−1+γei−2) where Pi+1 is a new power set point, Pi is a previous power set point, α, β and γ are preset values, G is a variable gain factor and ei, ei−1, ei−2 correspond to error at the present time step, error one step previous and error two steps previous where the error is the difference between the preset temperature and a measured temperature.

We have found that by using a variable gain factor (G) to adaptively control RF energy delivery, the system of the present invention can treat a wide range of tissue types including lung tissue bronchus, bronchioles and other airway passages. The variable gain factor scales the coefficients (alpha, beta, and gamma; each a function of the three PID parameters) based on, for example, the temperature response to energy input during the initial temperature ramp up.

Exemplary PID parameters are presented herein, expressed in alpha-beta-gamma space, for an energy delivering device and controller of the present invention. These settings and timings are based on testing in various animal lung tissues using an energy delivering apparatus as described above. First, the gain factor preferably varies and is reset 0.1 to 2 and more preferably at 0.5 seconds after energy delivery has begun. Preferably, the gain factor is reset as follows: G is reset to 0.9 to 1.0 and preferably 0.9 if a temperature rise in C. per Joule is less than or equal to 2.5; G is reset to 0.4 to 0.5 and preferably 0.5 if a temperature rise in C. per Joule is between 2.5 to 5.0; G is reset to 0.2 to 0.3 and preferably 0.2 if a temperature rise in C. per Joule is equal to 5.0 to 7.5; and G is reset to 0.1 to 0.2 and preferably 0.1 if a temperature rise in C. per Joule is greater than 7.5. We have also found that a suitable value for a is from 1 to 2; for β is from −1 to −2; and for γ is from −0.5 to 0.5. More preferably α, β, γ are 1.6, −1.6, and 0.0 respectively.

It is also possible to change the relative weights of alpha, beta, and gamma depending upon monitored temperature response working in either PID or Alpha-Beta-Gamma coordinate space beyond just scaling the alpha-beta-gamma coefficients with a variable gain factor. This can be done by individually adjusting any or all of alpha, beta, or gamma.

In another variation of the present invention, the PID algorithm is Pi+1=Pi+(G1ei+G2ei−1+G3ei−2) and G1, G2 and G3 are each variable gain factors. The invention includes configuring the controller such that G1, G2 and G3 are reset to 0.90 to 2.00, −0.90 to −2.00 and 0.50 to −0.50 respectively if a temperature rise in C. per Joule is less than or equal to 2.5; to 0.40 to 1.00, −0.40 to −1.00 and 0.25 to −0.25 respectively if a temperature rise in C. per Joule is between 2.5 to 5.0; to 0.20 to 0.60, −0.20 to −0.60 and 0.15 to −0.15 respectively if a temperature rise in C. per Joule is equal to 5.0 to 7.5; and to 0.10 to 0.40, −0.10 to −0.40 and 0.10 to −0.10 respectively if a temperature rise in C. per Joule is greater than 7.5. Each of the variable gain factors may be equal to a product of at least one preset value and at least one variable value.

It is also possible to employ an algorithm that continuously adapts to signals rather than at discrete sample steps, intervals or periods. The algorithm takes into account several variables upon which observed temperature response depends including, for example: initial temperature, time history of energy delivery, and the amount of energy required to maintain set point temperature. An exemplary analog PID algorithm is: u=Kpe+KI∫ edt+KD(de/dt) where u is a signal to be adjusted such as, for example, a current, a voltage difference, or an output power which results in energy delivery from the electrode to the airway wall. KP, KI and KD are preset or variable values which are multiplied with the proper error term where e(t) is the difference between a preset variable and a measured process variable such as temperature at time (t). The above equation is suitable for continuous and/or analog type controllers.

Power Shut Down Safety Algorithms

In addition to the control modes specified above, the power supply may include control algorithms to limit excessive thermal damage to the airway tissue. Damage may be limited by terminating or shutting down the energy being delivered to the target medium. The algorithms can be based on the expectation that the sensed temperature of the tissue will respond upon the application of energy. The temperature response, for example, may be a change in temperature in a specified time or the rate of change of temperature. The expected temperature response can be predicted as a function of the initially sensed temperature, the temperature data for a specified power level as a function of time, or any other variables found to affect tissue properties. The expected temperature response may thus be used as a parameter in a power supply safety algorithm. For example, if the measured temperature response is not within a predefined range of the expected temperature response, the power supply will automatically shut down.

Other control algorithms may also be employed. For example, an algorithm may be employed to shut down energy delivery if the sensed temperature does not rise by a certain number of degrees in a pre-specified amount of time after energy delivery begins. Preferably, if the sensed temperature does not increase more than about 10 C. in about 3 seconds, the power supply is shut off. More preferably, if the sensed temperature does not increase more than about 10 C. in about 1 second, the power supply is shut off.

Another way to stop energy delivery includes shutting down a power supply if the temperature ramp is not within a predefined range at any time during energy delivery. For example, if the measured rate of temperature change does not reach a predefined value, the power supply will stop delivery of the RF energy. The predefined values are predetermined and based on empirical data. Generally, the predefined values are based on the duration of time RF energy is delivered and the power-level applied. A suitable predefined rate of temperature change to stop energy delivery is from 8 C./second to 15 C./second in the first 5 seconds (preferably in the first 2 seconds) of commencing energy delivery.

Other algorithms include shutting down a power supply if a maximum temperature setting is exceeded or shutting down a power supply if the sensed temperature suddenly changes, such a change includes either a drop or rise, this change may indicate failure of the temperature sensing element. For example, the generator or power supply may be programmed to shut off if the sensed temperature drops more than about 10 C. in about 0.1 to 1 seconds and more preferably in about 0.2 seconds.

In another configuration, the power is terminated when the measured temperature exceeds a pre-selected temperature or exceeds the set point temperature by a pre-selected amount. For example, when the set point is exceeded by 5 to 20 C., more preferably 15 C. the power will terminate.

In another configuration, power is terminated when the measured temperature (averaged over a time window) exceeds a pre-selected temperature. For example, power may be terminated when the measured temperature (averaged over 1 to 5 seconds and preferably averaged over 2 seconds) exceeds the preset temperature by a predetermined amount. The predetermined amount is generally from 1 to 10 C. and preferably about 5 C. Suitable preset temperatures are from 60 to 80 C. and most preferably about 65 C. Accordingly, in one exemplary configuration, the power is stopped when the measured temperature (averaged over 2 seconds) exceeds 70 C.

In another configuration, the power is terminated when the amount of energy delivered exceeds a maximum amount. A suitable maximum amount is 120 Joules for an energy delivery apparatus delivering energy to the airways of lungs.

In another configuration, the power is shut down depending on an impedance measurement. The impedance is monitored across a treated area of tissue within the lung. Impedance may also be monitored at more than one site within the lungs. The measuring of impedance may be but is not necessarily performed by the same electrodes used to deliver the energy treatment to the tissue. The impedance may be measured as is known in the art and as taught in U.S. application Ser. No. 09/436,455 which is incorporated by reference in its entirety. Accordingly, in one variation of the present invention, the power is adjusted or shut off when a measured impedance drops below a preset impedance value. When using the energy delivering device of the present invention to treat airways, a suitable range for the preset impedance value is from 40 to 60 ohms and preferably about 50 ohms.

In another variation, the energy delivery apparatus is configured to deliver an amount of power up to a maximum power. The maximum power can be from 10 to 40 watts and preferably from 15 to 20 watts.

In yet another configuration, the power supply is configured to shut down if the power delivered exceeds a maximum power and the measured temperature drops by a critical temperature difference within a sampling period of time. A suitable maximum power is from 15 to 20 Watts and preferably about 17 watts. The sampling period of time generally ranges from 0.1 to 1.0 seconds and preferably is about 0.5 seconds. A suitable range for the critical temperature difference is about 2 C.

It is to be understood that any of the above algorithms and shut-down configurations may be combined in a single controller. However, algorithms having mutually exclusive functions may not be combined.

While the power supply or generator preferably includes or employs a microprocessor, the invention is not so limited. Other means known in the art may be employed. For example, the generator may be hardwired to run one or more of the above discussed algorithms.

The controller is preferably programmable and configured to receive and manipulate other signals than the examples provided above. For example, other useful sensors may provide input signals to the processor to be used in determining the power output for the next step. The treatment of an airway may also involve placing a visualization system such as an endoscope or bronchoscope into the airways. The treatment device is then inserted through or next to the bronchoscope or endoscope while visualizing the airways. Alternatively, the visualization system may be built directly into the treatment device using fiber optic imaging and lenses or a CCD and lens arranged at the distal portion of the treatment device. The treatment device may also be positioned using radiographic visualization such as fluoroscopy or other external visualization means.

EXAMPLES

A system to treat airways in accordance with the present invention was built and tested in vivo on two canines. The system included an energy delivering apparatus having a distal basket. The basket included electrode legs and a temperature sensor mounted to one of the legs. The system also included a generator programmed to measure the temperature change per energy unit during the first half-second of treatment. A PID gain factor was adjusted depending on the measured tissue response. That is, the gain factor was adjusted based on the temperature change per joule output during the first half second. In general, this corresponds to a higher gain for less responsive tissue and lower gain for more responsive tissue.

After treating the test subjects with a general anesthetic, RF energy was delivered to target regions using an energy delivery device and generator as described above. In particular, energy activations were performed on all available intraparenchymal airways three millimeters or larger in diameter in both lungs. Three hundred sixty-three activations using a 65 C. temperature setting were performed in the two animals (i.e., 180 activations per animal). Additionally, in twenty of the activations in each animal, the energy delivery device was deliberately deployed improperly to provide a “Stress” condition.

In each activation, the measured temperature reached and stabilized at 65 C. or, in the case of the twenty activations under “stress” conditions, the power properly shut off. Thus, the present invention can successfully treat lung tissue with a variable gain setting and various safety algorithms to safely maintain a preset temperature at the electrode or lung tissue surface. This temperature control is particularly advantageous when treating the airways of lungs to reduce asthma symptoms.

This invention has been described and specific embodiments or examples of the invention have been portrayed to convey a proper understanding of the invention. The use of such examples is not intended to limit the invention in any way. Additionally, to the extent that there are variations of the invention which are within the spirit of the disclosure and are equivalent to features found in the claims, it is the intent that the claims cover those variations as well. All equivalents are considered to be within the scope of the claimed invention, even those which may not have been set forth herein merely for the sake of brevity. Also, the various aspects of the invention described herein may be modified and/or used in combination with such other aspects also described to be part of the invention either explicitly or inherently to form other advantageous variations considered to be part of the invention covered by the claims which follow.

The invention described herein expressly incorporates the following co-pending applications by reference in their entirety: U.S. application Ser. No. 09/095,323; U.S. application Ser. No. 09/095,323; U.S. application Ser. No. 09/349,715; U.S. application Ser. No. 09/296,040; U.S. application Ser. No. 09/436,455; and U.S. application Ser. No. 09/535,856.

Patent Citations
Cited PatentFiling datePublication dateApplicantTitle
US612724Jun 4, 1897Oct 18, 1898 Bert j
US1155169Nov 28, 1914Sep 28, 1915John StarkweatherSurgical instrument.
US1207479Mar 5, 1915Dec 5, 1916Holger BisgaardSelf-retaining gatheter.
US1216183Sep 18, 1916Feb 13, 1917Charles M SwingleElectrotherapeutic rejuvenator.
US2072346Oct 4, 1934Mar 2, 1937Ward R SmithDrainage tube
US3320957May 21, 1964May 23, 1967Sokolik EdwardSurgical instrument
US3568659Sep 24, 1968Mar 9, 1971Karnegis James NDisposable percutaneous intracardiac pump and method of pumping blood
US3667476Apr 27, 1970Jun 6, 1972Bio Data CorpApparatus for monitoring body temperature and controlling a heating device to maintain a selected temperature
US3692029May 3, 1971Sep 19, 1972Adair Edwin LloydRetention catheter and suprapubic shunt
US3995617May 31, 1972Dec 7, 1976Watkins David HHeart assist method and catheter
US4095602Sep 27, 1976Jun 20, 1978Leveen Harry HMulti-portal radiofrequency generator
US4116589Apr 15, 1977Sep 26, 1978Avco CorporationExtracorporeal pulsatile blood pump comprised of side by side bladders
US4129129Mar 18, 1977Dec 12, 1978Sarns, Inc.Venous return catheter and a method of using the same
US4154246Jul 25, 1977May 15, 1979Leveen Harry HField intensification in radio frequency thermotherapy
US4461283Apr 2, 1982Jul 24, 1984Kabushiki Kaisha Medos KenkyushoEndoscopic laser coagulator
US4502490Oct 23, 1981Mar 5, 1985Antec Systems LimitedPatient monitoring equipment, probe for use therewith, and method of measuring anesthesia based on oesophagal contractions
US4503855Dec 30, 1982Mar 12, 1985Harald MaslankaHigh frequency surgical snare electrode
US4512762Nov 23, 1982Apr 23, 1985The Beth Israel Hospital AssociationMethod of treatment of atherosclerosis and a balloon catheter for same
US4522212Nov 14, 1983Jun 11, 1985Mansfield Scientific, Inc.Endocardial electrode
US4557272Feb 9, 1981Dec 10, 1985Microwave Associates, Inc.Microwave endoscope detection and treatment system
US4565200May 4, 1982Jan 21, 1986Cosman Eric RUniversal lesion and recording electrode system
US4567882Dec 10, 1984Feb 4, 1986Vanderbilt UniversityMethod for locating the illuminated tip of an endotracheal tube
US4584998Sep 11, 1981Apr 29, 1986Mallinckrodt, Inc.Multi-purpose tracheal tube
US4612934Jul 16, 1984Sep 23, 1986Borkan William NNon-invasive multiprogrammable tissue stimulator
US4621642Mar 14, 1985Nov 11, 1986North China Research Institute Of Electro-OpticsMicrowave apparatus for physiotherapeutic treatment of human and animal bodies
US4621882Nov 26, 1985Nov 11, 1986Beta Phase, Inc.Thermally responsive electrical connector
US4625712Sep 28, 1983Dec 2, 1986Nimbus, Inc.High-capacity intravascular blood pump utilizing percutaneous access
US4643186Oct 30, 1985Feb 17, 1987Rca CorporationPercutaneous transluminal microwave catheter angioplasty
US4646737Jun 13, 1983Mar 3, 1987Laserscope, Inc.Localized heat applying medical device
US4674497Jul 22, 1985Jun 23, 1987Olympus Optical Co., Ltd.Medical laser device
US4683890Oct 2, 1986Aug 4, 1987Brunswick Manufacturing Co., Inc.Method and apparatus for controlled breathing employing internal and external electrodes
US4704121Sep 28, 1983Nov 3, 1987Nimbus, Inc.Anti-thrombogenic blood pump
US4706688Oct 26, 1983Nov 17, 1987Don Michael T AnthonyNon-invasive cardiac device
US4709698May 14, 1986Dec 1, 1987Thomas J. FogartyHeatable dilation catheter
US4739759Feb 26, 1985Apr 26, 1988Concept, Inc.Microprocessor controlled electrosurgical generator
US4754065Jul 13, 1987Jun 28, 1988Cetus CorporationPrecursor to nucleic acid probe
US4754752Jul 27, 1987Jul 5, 1988Robert GinsburgVascular catheter
US4765959Nov 12, 1985Aug 23, 1988Terumo Kabushiki KaishaBlood circulating circuit for membrane-type artificial lung, and reservoir for use in blood circulating circuit
US4772112Jun 19, 1986Sep 20, 1988Cvi/Beta Ventures, Inc.Eyeglass frame including shape-memory elements
US4773899Jan 14, 1988Sep 27, 1988The Beth Israel Hospital AssociationMethod of treatment of artherosclerosis and balloon catheter the same
US4779614Apr 9, 1987Oct 25, 1988Nimbus Medical, Inc.Magnetically suspended rotor axial flow blood pump
US4784135Aug 11, 1986Nov 15, 1988International Business Machines CorporationFar ultraviolet surgical and dental procedures
US4790305Jun 23, 1986Dec 13, 1988The Johns Hopkins UniversityMedication delivery system
US4799479Jan 8, 1987Jan 24, 1989The Beth Israel Hospital AssociationMethod and apparatus for angioplasty
US4802492Mar 11, 1987Feb 7, 1989National Jewish Center For Immunology And Respiratory MedicineMethod for determining respiratory function
US4817586Nov 24, 1987Apr 4, 1989Nimbus Medical, Inc.Percutaneous bloom pump with mixed-flow output
US4825871May 18, 1987May 2, 1989Societe Anonyme Dite: AtesysDefibrillating or cardioverting electric shock system including electrodes
US4827935Apr 24, 1986May 9, 1989Purdue Research FoundationDemand electroventilator
US4846152Nov 24, 1987Jul 11, 1989Nimbus Medical, Inc.Single-stage axial flow blood pump
US4862886May 8, 1985Sep 5, 1989Summit Technology Inc.Laser angioplasty
US4895557Dec 7, 1987Jan 23, 1990Nimbus Medical, Inc.Drive mechanism for powering intravascular blood pumps
US4906229May 3, 1988Mar 6, 1990Nimbus Medical, Inc.High-frequency transvalvular axisymmetric blood pump
US4907589Apr 29, 1988Mar 13, 1990Cosman Eric RAutomatic over-temperature control apparatus for a therapeutic heating device
US4908012Aug 8, 1988Mar 13, 1990Nimbus Medical, Inc.Chronic ventricular assist system
US4920978Aug 31, 1988May 1, 1990Triangle Research And Development CorporationMethod and apparatus for the endoscopic treatment of deep tumors using RF hyperthermia
US4944722Feb 23, 1989Jul 31, 1990Nimbus Medical, Inc.Percutaneous axial flow blood pump
US4955377Oct 28, 1988Sep 11, 1990Lennox Charles DDevice and method for heating tissue in a patient's body
US4967765Jul 28, 1988Nov 6, 1990Bsd Medical CorporationUrethral inserted applicator for prostate hyperthermia
US4969865Jan 9, 1989Nov 13, 1990American Biomed, Inc.Helifoil pump
US4976709Jun 30, 1989Dec 11, 1990Sand Bruce JMethod for collagen treatment
US4985014Jul 11, 1989Jan 15, 1991Orejola Wilmo CVentricular venting loop
US4991603Oct 30, 1989Feb 12, 1991Siemens-Pacesetter, Inc.Transvenously placed defibrillation leads via an inferior vena cava access site and method of use
US5009636Dec 6, 1989Apr 23, 1991The Kendall CompanyDual-lumen catheter apparatus and method
US5009936Sep 5, 1989Apr 23, 1991Nissan Motor Co., Ltd.Method for forming tranparent multilayers
US5010892May 4, 1988Apr 30, 1991Triangle Research And Development Corp.Body lumen measuring instrument
US5019075Jul 31, 1990May 28, 1991The Beth Israel HospitalMethod and apparatus for angioplasty
US5027829Jun 21, 1989Jul 2, 1991Larsen Lawrence EApparatus for diathermy treatment and control
US5030645Oct 15, 1990Jul 9, 1991Merck & Co., Inc.Method of treating asthma using (S)-α-fluoromethyl-histidine and esters thereof
US5036848Oct 16, 1989Aug 6, 1991Brunswick Biomedical Technologies, Inc.Method and apparatus for controlling breathing employing internal and external electrodes
US5053033Oct 10, 1990Oct 1, 1991Boston Advanced Technologies, Inc.Inhibition of restenosis by ultraviolet radiation
US5056519May 14, 1990Oct 15, 1991Vince Dennis JUnilateral diaphragmatic pacer
US5074860Jun 9, 1989Dec 24, 1991Heraeus Lasersonics, Inc.Apparatus for directing 10.6 micron laser radiation to a tissue site
US5078716May 11, 1990Jan 7, 1992Doll Larry FElectrosurgical apparatus for resecting abnormal protruding growth
US5084044Jul 14, 1989Jan 28, 1992Ciron CorporationApparatus for endometrial ablation and method of using same
US5096916May 7, 1990Mar 17, 1992Aegis Technology, Inc.Treatment of chronic obstructive pulmonary disease (copd) by inhalation of an imidazoline
US5100388May 25, 1990Mar 31, 1992Interventional Thermodynamics, Inc.Method and device for thermal ablation of hollow body organs
US5100423Aug 21, 1990Mar 31, 1992Medical Engineering & Development Institute, Inc.Ablation catheter
US5103804Jul 3, 1990Apr 14, 1992Boston Scientific CorporationExpandable tip hemostatic probes and the like
US5105826Oct 26, 1990Apr 21, 1992Medtronic, Inc.Implantable defibrillation electrode and method of manufacture
US5106360Feb 11, 1991Apr 21, 1992Olympus Optical Co., Ltd.Thermotherapeutic apparatus
US5107830Mar 30, 1990Apr 28, 1992University Of ManitobaLung ventilator device
US5114423May 9, 1990May 19, 1992Advanced Cardiovascular Systems, Inc.Dilatation catheter assembly with heated balloon
US5116864Apr 9, 1991May 26, 1992Indiana University FoundationMethod for preventing restenosis following reconfiguration of body vessels
US5117828Sep 25, 1989Jun 2, 1992Arzco Medical Electronics, Inc.Expandable esophageal catheter
US5135517Jul 19, 1990Aug 4, 1992Catheter Research, Inc.Expandable tube-positioning apparatus
US5152286Sep 19, 1991Oct 6, 1992Mezhotraslevoi Nauchnoinzhenerny Tsentr "Vidguk"Method of microwave resonance therapy and device therefor
US5165420Dec 21, 1990Nov 24, 1992Ballard Medical ProductsBronchoalveolar lavage catheter
US5167223Sep 8, 1989Dec 1, 1992Tibor KorosHeart valve retractor and sternum spreader surgical instrument
US5170803Sep 28, 1990Dec 15, 1992Brunswick Biomedical Technologies, Inc.Esophageal displacement electrode
US5174288Nov 30, 1990Dec 29, 1992Medtronic, Inc.Method and apparatus for cardiac defibrillation
US5188602Jun 8, 1992Feb 23, 1993Interventional Thermodynamics, Inc.Method and device for delivering heat to hollow body organs
US5191883May 22, 1990Mar 9, 1993Prutech Research And Development Partnership IiDevice for heating tissue in a patient's body
US5213576Jun 11, 1991May 25, 1993Cordis CorporationTherapeutic porous balloon catheter
US5215103Sep 13, 1989Jun 1, 1993Desai Jawahar MCatheter for mapping and ablation and method therefor
US5231996Jan 28, 1992Aug 3, 1993Medtronic, Inc.Removable endocardial lead
US5232444Jun 21, 1989Aug 3, 1993Just HansjoergDilatation catheter
US5234456May 7, 1992Aug 10, 1993Pfizer Hospital Products Group, Inc.Hydrophilic stent
US5254088Dec 16, 1992Oct 19, 1993Ep Technologies, Inc.Catheter steering mechanism
US5255678Jun 21, 1991Oct 26, 1993Ecole PolytechniqueMapping electrode balloon
US5255679Jun 2, 1992Oct 26, 1993Cardiac Pathways CorporationEndocardial catheter for mapping and/or ablation with an expandable basket structure having means for providing selective reinforcement and pressure sensing mechanism for use therewith, and method
US5265604Apr 30, 1993Nov 30, 1993Vince Dennis JDemand - diaphragmatic pacing (skeletal muscle pressure modified)
US5269758Apr 29, 1992Dec 14, 1993Taheri Syde AIntravascular catheter and method for treatment of hypothermia
US5281218Jun 5, 1992Jan 25, 1994Cardiac Pathways CorporationCatheter having needle electrode for radiofrequency ablation
US5292331Aug 24, 1989Mar 8, 1994Applied Vascular Engineering, Inc.Endovascular support device
US5293869Sep 25, 1992Mar 15, 1994Ep Technologies, Inc.Cardiac probe with dynamic support for maintaining constant surface contact during heart systole and diastole
US5309910Sep 25, 1992May 10, 1994Ep Technologies, Inc.Cardiac mapping and ablation systems
US5313943Sep 25, 1992May 24, 1994Ep Technologies, Inc.Catheters and methods for performing cardiac diagnosis and treatment
US5324284Jun 5, 1992Jun 28, 1994Cardiac Pathways, Inc.Endocardial mapping and ablation system utilizing a separately controlled ablation catheter and method
US5343936Nov 24, 1992Sep 6, 1994Long Manufacturing Ltd.Spiral ripple circumferential flow heat exchanger
US5345936Jun 25, 1993Sep 13, 1994Cardiac Pathways CorporationApparatus with basket assembly for endocardial mapping
US5366443Oct 9, 1992Nov 22, 1994Thapliyal And Eggers PartnersMethod and apparatus for advancing catheters through occluded body lumens
US5368591Nov 23, 1992Nov 29, 1994Prutech Research And Development Partnership IiHeated balloon catheters
US5370644Jul 16, 1993Dec 6, 1994Sensor Electronics, Inc.Radiofrequency ablation catheter
US5370679Mar 21, 1994Dec 6, 1994Atlee, Iii; John L.Esophageal probe for transesophageal cardiac stimulation
US5374287Mar 24, 1993Dec 20, 1994British Technology Group Usa Inc.Defibrillator and demand pacer catheters and methods for using same
US5383917Jul 5, 1991Jan 24, 1995Jawahar M. DesaiDevice and method for multi-phase radio-frequency ablation
US5393207Jan 21, 1993Feb 28, 1995Nimbus, Inc.Blood pump with disposable rotor assembly
US5394880Mar 17, 1994Mar 7, 1995Atlee, Iii; John L.Esophageal stethoscope
US5396887Sep 23, 1993Mar 14, 1995Cardiac Pathways CorporationApparatus and method for detecting contact pressure
US5400778Jun 18, 1991Mar 28, 1995Siemens-Elema AbMethod and device for reduction of rebreathing of gas from dead space
US5400783Oct 12, 1993Mar 28, 1995Cardiac Pathways CorporationEndocardial mapping apparatus with rotatable arm and method
US5411025Jun 30, 1992May 2, 1995Cordis Webster, Inc.Cardiovascular catheter with laterally stable basket-shaped electrode array
US5415166Sep 28, 1993May 16, 1995Cardiac Pathways CorporationEndocardial mapping apparatus and cylindrical semiconductor device mounting structure for use therewith and method
US5415656Sep 28, 1993May 16, 1995American Medical Systems, Inc.Electrosurgical apparatus
US5417687Apr 30, 1993May 23, 1995Medical Scientific, Inc.Bipolar electrosurgical trocar
US5422362Jul 29, 1993Jun 6, 1995Quadra Logic Technologies, Inc.Method to inhibit restenosis
US5423744Oct 25, 1993Jun 13, 1995Gencheff; NelsonCatheter system for the deployment of biological material
US5423811Mar 16, 1994Jun 13, 1995Cardiac Pathways CorporationMethod for RF ablation using cooled electrode
US5425023Jul 13, 1992Jun 13, 1995Hitachi, Ltd.Network system and method of managing a maximum transfer unit in the network system
US5425703Jan 14, 1994Jun 20, 1995Feiring; Andrew J.Method and apparatus for inducing the permeation of medication into internal tissue
US5425811Oct 30, 1992Jun 20, 1995Kabushiki Kaisha ToshibaApparatus for manufacturing a nitrogen containing compound thin film
US5431696Oct 13, 1992Jul 11, 1995Atlee, Iii; John L.Esophageal probe for transeophageal cardiac stimulation
US5433730Oct 7, 1993Jul 18, 1995Intermedics, Inc.Conductive pouch electrode for defibrillation
US5437665Oct 12, 1993Aug 1, 1995Munro; Malcolm G.Electrosurgical loop electrode instrument for laparoscopic surgery
US5443470Apr 14, 1993Aug 22, 1995Vesta Medical, Inc.Method and apparatus for endometrial ablation
US5454782Aug 11, 1994Oct 3, 1995Perkins; Rodney C.Translumenal circumferential energy delivery device
US5456667May 20, 1993Oct 10, 1995Advanced Cardiovascular Systems, Inc.Temporary stenting catheter with one-piece expandable segment
US5458596May 6, 1994Oct 17, 1995Dorsal Orthopedic CorporationMethod and apparatus for controlled contraction of soft tissue
US5465717Aug 15, 1994Nov 14, 1995Cardiac Pathways CorporationApparatus and Method for ventricular mapping and ablation
US5471982Sep 29, 1992Dec 5, 1995Ep Technologies, Inc.Cardiac mapping and ablation systems
US5474530Jun 8, 1994Dec 12, 1995Baxter International Inc.Angioplasty and ablative devices having onboard ultrasound components and devices and methods for utilizing ultrasound to treat or prevent vasospasm
US5478309May 27, 1994Dec 26, 1995William P. Sweezer, Jr.Catheter system and method for providing cardiopulmonary bypass pump support during heart surgery
US5496271Jun 16, 1993Mar 5, 1996American Medical Systems, Inc.Combined hyperthermia and dilation catheter
US5496311May 2, 1994Mar 5, 1996Boston Scientific CorporationPhysiologic low stress angioplasty
US5496312Oct 7, 1993Mar 5, 1996Valleylab Inc.Impedance and temperature generator control
US5500011Nov 4, 1994Mar 19, 1996Desai; Jawahar M.Catheter for mapping and ablation and method therefor
US5505728Jan 9, 1995Apr 9, 1996Ellman; Alan G.Electrosurgical stripping electrode for palatopharynx tissue
US5505730Jun 24, 1994Apr 9, 1996Stuart D. EdwardsThin layer ablation apparatus
US5507791Aug 30, 1994Apr 16, 1996Sit'ko; Sergei P.Microwave resonance therapy
US5509419Dec 16, 1993Apr 23, 1996Ep Technologies, Inc.Cardiac mapping and ablation systems
US5522862Sep 21, 1994Jun 4, 1996Medtronic, Inc.Method and apparatus for treating obstructive sleep apnea
US5531779Jan 24, 1995Jul 2, 1996Cardiac Pacemakers, Inc.Stent-type defibrillation electrode structures
US5540681Jan 10, 1994Jul 30, 1996Medtronic CardiorhythmMethod and system for radiofrequency ablation of tissue
US5545161Oct 7, 1994Aug 13, 1996Cardiac Pathways CorporationCatheter for RF ablation having cooled electrode with electrically insulated sleeve
US5545193Aug 22, 1995Aug 13, 1996Ep Technologies, Inc.Helically wound radio-frequency emitting electrodes for creating lesions in body tissue
US5547469May 13, 1994Aug 20, 1996Boston Scientific CorporationApparatus for performing diagnostic and therapeutic modalities in the biliary tree
US5549559Mar 11, 1994Aug 27, 1996Argomed Ltd.Thermal treatment apparatus
US5549655Sep 21, 1994Aug 27, 1996Medtronic, Inc.Method and apparatus for synchronized treatment of obstructive sleep apnea
US5549661Dec 1, 1995Aug 27, 1996Ep Technologies, Inc.Systems and methods for creating complex lesion patterns in body tissue
US5558073Mar 27, 1995Sep 24, 1996Cardiac Pathways CorporationEndocardial mapping apparatus with rotatable arm and method
US5562608Apr 13, 1995Oct 8, 1996Biopulmonics, Inc.Apparatus for pulmonary delivery of drugs with simultaneous liquid lavage and ventilation
US5571074May 27, 1994Nov 5, 1996Temple University-Of The Commonwealth System Of Higher EducationInflatable and expandable direct manual cardiac compression device
US5571088Jun 6, 1995Nov 5, 1996Boston Scientific CorporationAblation catheters
US5574059Oct 27, 1995Nov 12, 1996Cornell Research Foundation, Inc.Treating disorders mediated by vascular smooth muscle cell proliferation
US5578072Aug 1, 1994Nov 26, 1996Barone; Hector D.Aortic graft and apparatus for repairing an abdominal aortic aneurysm
US5582609Aug 8, 1994Dec 10, 1996Ep Technologies, Inc.Systems and methods for forming large lesions in body tissue using curvilinear electrode elements
US5588432Jul 10, 1995Dec 31, 1996Boston Scientific CorporationCatheters for imaging, sensing electrical potentials, and ablating tissue
US5588812Apr 19, 1995Dec 31, 1996Nimbus, Inc.Implantable electric axial-flow blood pump
US5595183Feb 17, 1995Jan 21, 1997Ep Technologies, Inc.Systems and methods for examining heart tissue employing multiple electrode structures and roving electrodes
US5598848Mar 31, 1994Feb 4, 1997Ep Technologies, Inc.Systems and methods for positioning multiple electrode structures in electrical contact with the myocardium
US5599345Aug 24, 1994Feb 4, 1997Zomed International, Inc.RF treatment apparatus
US5601088Feb 17, 1995Feb 11, 1997Ep Technologies, Inc.Systems and methods for filtering artifacts from composite signals
US5605157Feb 17, 1995Feb 25, 1997Ep Technologies, Inc.Systems and methods for filtering signals derived from biological events
US5607419Apr 24, 1995Mar 4, 1997Angiomedics Ii Inc.Method and apparatus for treating vessel wall with UV radiation following angioplasty
US5607462Jul 7, 1994Mar 4, 1997Cardiac Pathways CorporationCatheter assembly, catheter and multi-catheter introducer for use therewith
US5620438Apr 20, 1995Apr 15, 1997Angiomedics Ii IncorporatedMethod and apparatus for treating vascular tissue following angioplasty to minimize restenosis
US5623940Aug 2, 1994Apr 29, 1997S.L.T. Japan Co., Ltd.Catheter apparatus with a sensor
US5624439Aug 18, 1995Apr 29, 1997Somnus Medical Technologies, Inc.Method and apparatus for treatment of air way obstructions
US5626618Sep 24, 1993May 6, 1997The Ohio State UniversityMechanical adjunct to cardiopulmonary resuscitation (CPR), and an electrical adjunct to defibrillation countershock, cardiac pacing, and cardiac monitoring
US5630425Feb 17, 1995May 20, 1997Ep Technologies, Inc.Systems and methods for adaptive filtering artifacts from composite signals
US5630794Sep 23, 1994May 20, 1997Vidamed, Inc.Catheter tip and method of manufacturing
US5634471Sep 8, 1993Jun 3, 1997British Technology Group LimitedFlowmeters
US5641326Dec 13, 1993Jun 24, 1997Angeion CorporationMethod and apparatus for independent atrial and ventricular defibrillation
US5647870Jan 16, 1996Jul 15, 1997Ep Technologies, Inc.Multiple electrode support structures
US5660175Aug 21, 1995Aug 26, 1997Dayal; BimalEndotracheal device
US5678535Apr 21, 1995Oct 21, 1997Dimarco; Anthony FortunatoMethod and apparatus for electrical stimulation of the respiratory muscles to achieve artificial ventilation in a patient
US5680860Oct 31, 1995Oct 28, 1997Cardiac Pathways CorporationMapping and/or ablation catheter with coilable distal extremity and method for using same
US5681280May 2, 1995Oct 28, 1997Heart Rhythm Technologies, Inc.Catheter control system
US5681308Nov 28, 1994Oct 28, 1997Stuart D. EdwardsAblation apparatus for cardiac chambers
US5687723Jun 8, 1995Nov 18, 1997Avitall; BoazMapping and ablation catheter system
US5688267 *May 1, 1995Nov 18, 1997Ep Technologies, Inc.Systems and methods for sensing multiple temperature conditions during tissue ablation
US5693078Oct 5, 1994Dec 2, 1997Jawahar M. DesaiDevice and method for multi-phase radio-frequency ablation
US5694934Apr 17, 1996Dec 9, 1997Beth Israel HospitalMR studies in which a paramagnetic gas is administered to a living patient
US5695471Feb 20, 1996Dec 9, 1997Kriton Medical, Inc.Sealless rotary blood pump with passive magnetic radial bearings and blood immersed axial bearings
US5699799Mar 26, 1996Dec 23, 1997Siemens Corporate Research, Inc.Automatic determination of the curved axis of a 3-D tube-shaped object in image volume
US5702386Jun 28, 1996Dec 30, 1997Ep Technologies, Inc.Non-linear control systems and methods for heating and ablating body tissue
US5707218Sep 13, 1996Jan 13, 1998Nimbus, Inc.Implantable electric axial-flow blood pump with blood cooled bearing
US5707336Jan 9, 1995Jan 13, 1998Cardassist IncorporatedVentricular assist device
US5707352Jun 7, 1995Jan 13, 1998Alliance Pharmaceutical Corp.Pulmonary delivery of therapeutic agent
US5722401Nov 13, 1995Mar 3, 1998Cardiac Pathways CorporationEndocardial mapping and/or ablation catheter probe
US5722403Oct 28, 1996Mar 3, 1998Ep Technologies, Inc.Systems and methods using a porous electrode for ablating and visualizing interior tissue regions
US5722416Feb 17, 1995Mar 3, 1998Ep Technologies, Inc.Systems and methods for analyzing biopotential morphologies in heart tissue to locate potential ablation sites
US5725525Jan 16, 1996Mar 10, 1998Ep Technologies, Inc.Multiple electrode support structures with integral hub and spline elements
US5727569Feb 20, 1996Mar 17, 1998Cardiothoracic Systems, Inc.Surgical devices for imposing a negative pressure to fix the position of cardiac tissue during surgery
US5728094May 3, 1996Mar 17, 1998Somnus Medical Technologies, Inc.Method and apparatus for treatment of air way obstructions
US5730128Sep 24, 1996Mar 24, 1998Cardiac Pathways CorporationEndocardial mapping apparatus
US5730704May 6, 1996Mar 24, 1998Avitall; BoazLoop electrode array mapping and ablation catheter for cardiac chambers
US5730726Mar 4, 1996Mar 24, 1998Klingenstein; Ralph JamesApparatus and method for removing fecal impaction
US5730741Feb 7, 1997Mar 24, 1998Eclipse Surgical Technologies, Inc.Guided spiral catheter
US5735846May 1, 1995Apr 7, 1998Ep Technologies, Inc.Systems and methods for ablating body tissue using predicted maximum tissue temperature
US5740808Oct 28, 1996Apr 21, 1998Ep Technologies, IncSystems and methods for guilding diagnostic or therapeutic devices in interior tissue regions
US5741248Jun 7, 1995Apr 21, 1998Temple University-Of The Commonwealth System Of Higher EducationFluorochemical liquid augmented cryosurgery
US5752518Oct 28, 1996May 19, 1998Ep Technologies, Inc.Systems and methods for visualizing interior regions of the body
US5755714Sep 17, 1996May 26, 1998Eclipse Surgical Technologies, Inc.Shaped catheter for transmyocardial revascularization
US5755753May 5, 1995May 26, 1998Thermage, Inc.Method for controlled contraction of collagen tissue
US5759158Aug 19, 1997Jun 2, 1998E.P. Technologies, Inc.Systems and methods for conducting electrophysiological testing using high-voltage energy pulses to stun heart tissue
US5765568Dec 1, 1995Jun 16, 1998Heartport, Inc.Catheter system and method for venting the left ventricle
US5769846Apr 21, 1995Jun 23, 1998Stuart D. EdwardsAblation apparatus for cardiac chambers
US5772590Jun 7, 1995Jun 30, 1998Cordis Webster, Inc.Cardiovascular catheter with laterally stable basket-shaped electrode array with puller wire
US5779669Oct 28, 1996Jul 14, 1998C. R. Bard, Inc.Steerable catheter with fixed curve
US5779698May 11, 1994Jul 14, 1998Applied Medical Resources CorporationAngioplasty catheter system and method for making same
US5782239Jun 7, 1995Jul 21, 1998Cordis Webster, Inc.Unique electrode configurations for cardiovascular electrode catheter with built-in deflection method and central puller wire
US5782797Jun 6, 1996Jul 21, 1998Scimed Life Systems, Inc.Therapeutic infusion device
US5782827Dec 19, 1995Jul 21, 1998Rita Medical Systems, Inc.Multiple antenna ablation apparatus and method with multiple sensor feedback
US5782848Sep 3, 1996Jul 21, 1998Boston Scientific CorporationResecting coagulated tissue
US5782899Aug 28, 1996Jul 21, 1998Cardiac Pathways CorporationEndocardial mapping and ablation system utilizing a separately controlled ablation catheter and method
US5792064Oct 21, 1997Aug 11, 1998Panescu; DorinSystems and methods for analyzing cardiac biopotential morphologies by cross-correlation
US5795303Sep 2, 1997Aug 18, 1998Ep Technologies, Inc.Systems and methods for making time-sequential measurements of biopotentials sensed in myocardial tissue
US5800375Dec 20, 1995Sep 1, 1998Heartport, Inc.Catheter system and method for providing cardiopulmonary bypass pump support during heart surgery
US5807306Aug 16, 1994Sep 15, 1998Cortrak Medical, Inc.Polymer matrix drug delivery apparatus
US5810757Dec 1, 1995Sep 22, 1998Heartport, Inc.Catheter system and method for total isolation of the heart
US5810807Oct 15, 1996Sep 22, 1998Ganz; Robert A.Sphincterotome with deflectable cutting plane and method of using the same
US5817028Feb 23, 1995Oct 6, 1998Central Sydney Area Health ServiceMethod and device for the provocation of air passage narrowing and/or the induction of sputum
US5817073Jun 2, 1995Oct 6, 1998Krespi; Yosef P.Apparatus for administering local anesthetics and therapeutic medications during endoscopic surgery
US5820554Mar 24, 1997Oct 13, 1998Medtronic, Inc.Ultrasound biopsy needle
US5823189Nov 8, 1995Oct 20, 1998Ep Technologies, Inc.Multiple electrode support structures with spline elements and over-molded hub
US5827277Jan 29, 1997Oct 27, 1998Somnus Medical Technologies, Inc.Minimally invasive apparatus for internal ablation of turbinates
US5833651Nov 8, 1996Nov 10, 1998Medtronic, Inc.Therapeutic intraluminal stents
US5836905Dec 27, 1996Nov 17, 1998Lemelson; Jerome H.Apparatus and methods for gene therapy
US5836947Oct 11, 1994Nov 17, 1998Ep Technologies, Inc.Flexible structures having movable splines for supporting electrode elements
US5837001Dec 8, 1995Nov 17, 1998C. R. BardRadio frequency energy delivery system for multipolar electrode catheters
US5843075Feb 6, 1997Dec 1, 1998Engineering & Research Associates, Inc.Probe for thermal ablation
US5843077Jan 29, 1997Dec 1, 1998Somnus Medical Technologies, Inc.Minimally invasive apparatus for internal ablation of turbinates with surface cooling
US5846238Apr 8, 1996Dec 8, 1998Ep Technologies, Inc.Expandable-collapsible electrode structures with distal end steering or manipulation
US5848969Oct 28, 1996Dec 15, 1998Ep Technologies, Inc.Systems and methods for visualizing interior tissue regions using expandable imaging structures
US5848972Sep 13, 1996Dec 15, 1998Children's Medical Center CorporationMethod for endocardial activation mapping using a multi-electrode catheter
US5849026Aug 29, 1997Dec 15, 1998Zhou; LinPhysiotherapy method
US5855577Feb 7, 1997Jan 5, 1999Eclipse Surgical Technologies, Inc.Bow shaped catheter
US5860974Feb 11, 1997Jan 19, 1999Boston Scientific CorporationHeart ablation catheter with expandable electrode and method of coupling energy to an electrode on a catheter shaft
US5863291Apr 8, 1996Jan 26, 1999Cardima, Inc.Linear ablation assembly
US5865791Jun 23, 1997Feb 2, 1999E.P. Technologies Inc.Atrial appendage stasis reduction procedure and devices
US5868740Mar 24, 1995Feb 9, 1999Board Of Regents-Univ Of NebraskaMethod for volumetric tissue ablation
US5871443Nov 14, 1996Feb 16, 1999Ep Technologies, Inc.Cardiac mapping and ablation systems
US5871523Aug 12, 1996Feb 16, 1999Ep Technologies, Inc.Helically wound radio-frequency emitting electrodes for creating lesions in body tissue
US5873852Jan 10, 1997Feb 23, 1999Interventional TechnologiesDevice for injecting fluid into a wall of a blood vessel
US5873865Feb 7, 1997Feb 23, 1999Eclipse Surgical Technologies, Inc.Spiral catheter with multiple guide holes
US5876340Apr 17, 1997Mar 2, 1999Irvine Biomedical, Inc.Ablation apparatus with ultrasonic imaging capabilities
US5876399May 28, 1997Mar 2, 1999Irvine Biomedical, Inc.Catheter system and methods thereof
US5881727Jan 4, 1996Mar 16, 1999Ep Technologies, Inc.Integrated cardiac mapping and ablation probe
US5882346Jul 15, 1996Mar 16, 1999Cardiac Pathways CorporationShapable catheter using exchangeable core and method of use
US5891135Apr 8, 1996Apr 6, 1999Ep Technologies, Inc.Stem elements for securing tubing and electrical wires to expandable-collapsible electrode structures
US5891136Apr 8, 1996Apr 6, 1999Ep Technologies, Inc.Expandable-collapsible mesh electrode structures
US5891138Aug 11, 1997Apr 6, 1999Irvine Biomedical, Inc.Catheter system having parallel electrodes
US5893847May 15, 1996Apr 13, 1999Ep Technologies, Inc.Multiple electrode support structures with slotted hub and hoop spline elements
US5897554Mar 1, 1997Apr 27, 1999Irvine Biomedical, Inc.Steerable catheter having a loop electrode
US5899882Apr 4, 1996May 4, 1999Novoste CorporationCatheter apparatus for radiation treatment of a desired area in the vascular system of a patient
US5904651Oct 28, 1996May 18, 1999Ep Technologies, Inc.Systems and methods for visualizing tissue during diagnostic or therapeutic procedures
US5904711Feb 8, 1996May 18, 1999Heartport, Inc.Expandable thoracoscopic defibrillation catheter system and method
US5906636Sep 19, 1997May 25, 1999Texas Heart InstituteHeat treatment of inflamed tissue
US5908445Oct 28, 1996Jun 1, 1999Ep Technologies, Inc.Systems for visualizing interior tissue regions including an actuator to move imaging element
US5908446Mar 4, 1997Jun 1, 1999Cardiac Pathways CorporationCatheter assembly, catheter and multi-port introducer for use therewith
US5908839Aug 23, 1996Jun 1, 1999Magainin Pharmaceuticals, Inc.Asthma associated factors as targets for treating atopic allergies including asthma and related disorders
US5911218Mar 18, 1997Jun 15, 1999Dimarco; Anthony FortunatoMethod and apparatus for electrical stimulation of the respiratory muscles to achieve artificial ventilation in a patient
US5916235Aug 13, 1997Jun 29, 1999The Regents Of The University Of CaliforniaApparatus and method for the use of detachable coils in vascular aneurysms and body cavities
US5919147Nov 1, 1996Jul 6, 1999Jain; Krishna M.Method and apparatus for measuring the vascular diameter of a vessel
US5919172Jul 17, 1996Jul 6, 1999Becton, Dickinson And CompanyHypodermic needle having a differential surface finish
US5924424Oct 14, 1997Jul 20, 1999Heartport, Inc.Method and apparatus for thoracoscopic intracardiac procedures
US5928228Feb 18, 1997Jul 27, 1999Ep Technologies, Inc.Flexible high density multiple electrode circuit assemblies employing ribbon cable
US5931835Jun 13, 1997Aug 3, 1999C. R. BardRadio frequency energy delivery system for multipolar electrode catheters
US5935079Sep 8, 1997Aug 10, 1999Ep Technologies, Inc.Systems and methods for positioning multiple electrode structures in electrical contact with the myocardium
US5941869May 16, 1997Aug 24, 1999Prolifix Medical, Inc.Apparatus and method for controlled removal of stenotic material from stents
US5951494Jan 16, 1997Sep 14, 1999Boston Scientific CorporationPolymeric implements for torque transmission
US5951546Nov 24, 1995Sep 14, 1999Lorentzen; TorbenElectrosurgical instrument for tissue ablation, an apparatus, and a method for providing a lesion in damaged and diseased tissue from a mammal
US5954661Mar 31, 1997Sep 21, 1999Thomas Jefferson UniversityTissue characterization and treatment using pacing
US5954662Oct 21, 1997Sep 21, 1999Ep Technologies, Inc.Systems and methods for acquiring endocardially or epicardially paced electrocardiograms
US5954717Sep 25, 1997Sep 21, 1999Radiotherapeutics CorporationMethod and system for heating solid tissue
US5957961Jan 9, 1998Sep 28, 1999Medtronic, Inc.Multiple sensor, temperature controlled R-F ablation system
US5964753Jan 5, 1998Oct 12, 1999Ep Technologies, Inc.Integrated cardiac mapping and ablation probe
US5964796Aug 25, 1998Oct 12, 1999Cardiac Pathways CorporationCatheter assembly, catheter and multi-port introducer for use therewith
US5971983May 9, 1997Oct 26, 1999The Regents Of The University Of CaliforniaTissue ablation device and method of use
US5972026Jan 7, 1998Oct 26, 1999Broncus Technologies, Inc.Bronchial stenter having diametrically adjustable electrodes
US5976175Jun 18, 1996Nov 2, 1999Lederle (Japan), Ltd.Fiber optic laser conducting probe for photodynamic therapy
US5976709May 23, 1997Nov 2, 1999Hitachi Kinzoku Kabushiki KaishaAluminum alloy member, with insert provided therein, possessing improved damping capacity and process for producing the same
US5979456Apr 22, 1996Nov 9, 1999Magovern; George J.Apparatus and method for reversibly reshaping a body part
US5980563Aug 31, 1998Nov 9, 1999Tu; Lily ChenAblation apparatus and methods for treating atherosclerosis
US5984917Oct 1, 1997Nov 16, 1999Ep Technologies, Inc.Device and method for remote insertion of a closed loop
US5984971Feb 15, 1996Nov 16, 1999Tecres S.P.A.Prosthesis for metacarpal-phalangeal and interphalangeal joints in hands or feet
US5991650Jun 20, 1997Nov 23, 1999Ep Technologies, Inc.Surface coatings for catheters, direct contacting diagnostic and therapeutic devices
US5992419Aug 20, 1998Nov 30, 1999Mmtc, Inc.Method employing a tissue-heating balloon catheter to produce a "biological stent" in an orifice or vessel of a patient's body
US5993462Mar 27, 1998Nov 30, 1999Cardiac Pathways CorporationShapable catheter using exchangeable core and method of use
US5997534Jun 8, 1998Dec 7, 1999Tu; HoshengMedical ablation device and methods thereof
US5999855Dec 30, 1998Dec 7, 1999Dimarco; Anthony F.Method and apparatus for electrical activation of the expiratory muscles to restore cough
US6001054May 19, 1998Dec 14, 1999Regulla; D. F.Method and apparatus for differential energy application for local dose enhancement of ionizing radiation
US6003517Apr 30, 1998Dec 21, 1999Ethicon Endo-Surgery, Inc.Method for using an electrosurgical device on lung tissue
US6004269Jun 7, 1995Dec 21, 1999Boston Scientific CorporationCatheters for imaging, sensing electrical potentials, and ablating tissue
US6006755Feb 19, 1998Dec 28, 1999Edwards; Stuart D.Method to detect and treat aberrant myoelectric activity
US6008211Jul 27, 1995Dec 28, 1999Pdt Pharmaceuticals, Inc.Photoactivatable compounds comprising benzochlorin and furocoumarin
US6009877Feb 19, 1998Jan 4, 2000Edwards; Stuart D.Method for treating a sphincter
US6010500Jul 21, 1997Jan 4, 2000Cardiac Pathways CorporationTelescoping apparatus and method for linear lesion ablation
US6014579Jul 21, 1997Jan 11, 2000Cardiac Pathways Corp.Endocardial mapping catheter with movable electrode
US6016437Aug 21, 1998Jan 18, 2000Irvine Biomedical, Inc.Catheter probe system with inflatable soft shafts
US6023638May 22, 1998Feb 8, 2000Scimed Life Systems, Inc.System and method for conducting electrophysiological testing using high-voltage energy pulses to stun tissue
US6024740Jul 8, 1997Feb 15, 2000The Regents Of The University Of CaliforniaCircumferential ablation device assembly
US6029091Jul 9, 1998Feb 22, 2000Irvine Biomedical, Inc.Catheter system having lattice electrodes
US6033397Sep 26, 1996Mar 7, 2000Vnus Medical Technologies, Inc.Method and apparatus for treating esophageal varices
US6036687Mar 5, 1996Mar 14, 2000Vnus Medical Technologies, Inc.Method and apparatus for treating venous insufficiency
US6036689Sep 24, 1998Mar 14, 2000Tu; Lily ChenAblation device for treating atherosclerotic tissues
US6039731Oct 29, 1998Mar 21, 2000Engineering & Research Associates, Inc.Apparatus and method for determining the extent of ablation
US6045549Sep 30, 1997Apr 4, 2000Somnus Medical Technologies, Inc.Tissue ablation apparatus and device for use therein and method
US6045550May 5, 1998Apr 4, 2000Cardiac Peacemakers, Inc.Electrode having non-joined thermocouple for providing multiple temperature-sensitive junctions
US6050992May 19, 1997Apr 18, 2000Radiotherapeutics CorporationApparatus and method for treating tissue with multiple electrodes
US6053172May 22, 1998Apr 25, 2000Arthrocare CorporationSystems and methods for electrosurgical sinus surgery
US6053909Mar 27, 1998Apr 25, 2000Shadduck; John H.Ionothermal delivery system and technique for medical procedures
US6056744Feb 19, 1998May 2, 2000Conway Stuart Medical, Inc.Sphincter treatment apparatus
US6056769Jul 31, 1998May 2, 2000Biointerventional CorporationExpansile device for use in blood vessels and tracts in the body and tension application device for use therewith and method
US6063078Mar 12, 1997May 16, 2000Medtronic, Inc.Method and apparatus for tissue ablation
US6071280Feb 14, 1997Jun 6, 2000Rita Medical Systems, Inc.Multiple electrode ablation apparatus
US6071281 *May 5, 1998Jun 6, 2000Ep Technologies, Inc.Surgical method and apparatus for positioning a diagnostic or therapeutic element within the body and remote power control unit for use with same
US6071282Dec 3, 1998Jun 6, 2000Ep Technologies, Inc.Structures for deploying electrode elements
US6083255Dec 19, 1997Jul 4, 2000Broncus Technologies, Inc.Bronchial stenter
US6090104Jun 7, 1995Jul 18, 2000Cordis Webster, Inc.Catheter with a spirally wound flat ribbon electrode
US6092528Mar 6, 1998Jul 25, 2000Edwards; Stuart D.Method to treat esophageal sphincters
US6102886May 27, 1998Aug 15, 2000Vidamed, Inc.Steerable medical probe with stylets
US6106524Jul 3, 1997Aug 22, 2000Neothermia CorporationMethods and apparatus for therapeutic cauterization of predetermined volumes of biological tissue
US6123702Sep 10, 1998Sep 26, 2000Scimed Life Systems, Inc.Systems and methods for controlling power in an electrosurgical probe
US6123703Sep 19, 1998Sep 26, 2000Tu; Lily ChenAblation catheter and methods for treating tissues
US6139527Sep 26, 1996Oct 31, 2000Vnus Medical Technologies, Inc.Method and apparatus for treating hemorrhoids
US6139571Jul 9, 1997Oct 31, 2000Fuller Research CorporationHeated fluid surgical instrument
US6142993Feb 27, 1998Nov 7, 2000Ep Technologies, Inc.Collapsible spline structure using a balloon as an expanding actuator
US6143013Apr 30, 1996Nov 7, 2000Target Therapeutics, Inc.High performance braided catheter
US6149647Apr 19, 1999Nov 21, 2000Tu; Lily ChenApparatus and methods for tissue treatment
US6152143Apr 3, 1998Nov 28, 2000Somnus Medical Technologies, Inc.Method for treatment of air way obstructions
US6152899Jul 17, 1997Nov 28, 2000Vnus Medical Technologies, Inc.Expandable catheter having improved electrode design, and method for applying energy
US6159194Oct 2, 1997Dec 12, 2000Arthrocare CorporationSystem and method for electrosurgical tissue contraction
US6179833Aug 24, 1999Jan 30, 2001Engineering & Research Associates, Inc.Apparatus for thermal ablation
US6183468Sep 10, 1998Feb 6, 2001Scimed Life Systems, Inc.Systems and methods for controlling power in an electrosurgical probe
US6198970Jan 25, 1999Mar 6, 2001Esd Limited Liability CompanyMethod and apparatus for treating oropharyngeal respiratory and oral motor neuromuscular disorders with electrical stimulation
US6200311Jan 20, 1998Mar 13, 2001Eclipse Surgical Technologies, Inc.Minimally invasive TMR device
US6200332Jul 9, 1999Mar 13, 2001Ceramoptec Industries, Inc.Device and method for underskin laser treatments
US6200333Dec 31, 1998Mar 13, 2001Broncus Technologies, Inc.Bronchial stenter
US6210367Aug 4, 1999Apr 3, 2001Microwave Medical Systems, Inc.Intracorporeal microwave warming method and apparatus
US6212433Jul 28, 1998Apr 3, 2001Radiotherapeutics CorporationMethod for treating tumors near the surface of an organ
US6214002Mar 13, 2000Apr 10, 2001Ep Technologies, Inc.Structures and methods for deploying electrode elements
US6216043Oct 28, 1996Apr 10, 2001Ep Technologies, Inc.Asymmetric multiple electrode support structures
US6216044Jul 9, 1998Apr 10, 2001Ep Technologies, Inc.Medical device with three dimensional collapsible basket structure
US6217576Apr 1, 1999Apr 17, 2001Irvine Biomedical Inc.Catheter probe for treating focal atrial fibrillation in pulmonary veins
US6235024Jun 21, 1999May 22, 2001Hosheng TuCatheters system having dual ablation capability
US6241727Jul 9, 1999Jun 5, 2001Irvine Biomedical, Inc.Ablation catheter system having circular lesion capabilities
US6245065Sep 10, 1998Jun 12, 2001Scimed Life Systems, Inc.Systems and methods for controlling power in an electrosurgical probe
US6254598Jan 20, 1999Jul 3, 2001Curon Medical, Inc.Sphincter treatment apparatus
US6258087May 4, 1999Jul 10, 2001Curon Medical, Inc.Expandable electrode assemblies for forming lesions to treat dysfunction in sphincters and adjoining tissue regions
US6264653Sep 24, 1999Jul 24, 2001C. R. Band, Inc.System and method for gauging the amount of electrode-tissue contact using pulsed radio frequency energy
US6269813Jan 15, 1999Aug 7, 2001Respironics, Inc.Tracheal gas insufflation bypass and phasic delivery system and method
US6270476Apr 23, 1999Aug 7, 2001Cryocath Technologies, Inc.Catheter
US6273907Apr 7, 1997Aug 14, 2001Broncus Technologies, Inc.Bronchial stenter
US6283988Mar 1, 1999Sep 4, 2001Broncus Technologies, Inc.Bronchial stenter having expandable electrodes
US6283989Mar 29, 1999Sep 4, 2001Broncus Technolgies, Inc.Method of treating a bronchial tube with a bronchial stenter having diametrically adjustable electrodes
US6287304Oct 15, 1999Sep 11, 2001Neothermia CorporationInterstitial cauterization of tissue volumes with electrosurgically deployed electrodes
US6296639Feb 12, 1999Oct 2, 2001NovaceptApparatuses and methods for interstitial tissue removal
US6299633Oct 22, 1998Oct 9, 2001Broncus Technologies, Inc.Bronchial stenter
US6322559Jul 6, 1998Nov 27, 2001Vnus Medical Technologies, Inc.Electrode catheter having coil structure
US6322584Oct 13, 1998Nov 27, 2001Surx, Inc.Temperature sensing devices and methods to shrink tissues
US6338727Aug 13, 1998Jan 15, 2002Alsius CorporationIndwelling heat exchange catheter and method of using same
US6338836Sep 28, 1999Jan 15, 2002Siemens AktiengesellschaftAsthma analysis method employing hyperpolarized gas and magnetic resonance imaging
US6346104Apr 30, 1997Feb 12, 2002Western Sydney Area Health ServiceSystem for simultaneous unipolar multi-electrode ablation
US6355031May 4, 1999Mar 12, 2002Curon Medical, Inc.Control systems for multiple electrode arrays to create lesions in tissue regions at or near a sphincter
US6379352Mar 22, 2000Apr 30, 2002Ep Technologies, Inc.Large surface cardiac ablation catherter that assumes a low profile during introduction into the heart
US6409723Apr 2, 1999Jun 25, 2002Stuart D. EdwardsTreating body tissue by applying energy and substances
US6411852Apr 21, 1999Jun 25, 2002Broncus Technologies, Inc.Modification of airways by application of energy
US6416511Aug 17, 2000Jul 9, 2002The Regents Of The University Of CaliforniaCircumferential ablation device assembly
US6416740May 11, 1998Jul 9, 2002Bristol-Myers Squibb Medical Imaging, Inc.Acoustically active drug delivery systems
US6423105Apr 23, 1999Jul 23, 2002Tdk CorporationProcess for producing an electrode for a battery
US6425895Aug 22, 2000Jul 30, 2002Ep Technologies, Inc.Surgical apparatus for positioning a diagnostic or therapeutic element within the body
US6440129Feb 10, 2000Aug 27, 2002Cardiac Pacemakers, Inc.Electrode having non-joined thermocouple for providing multiple temperature-sensitive junctions
US6442435May 21, 2001Aug 27, 2002Medtronic, Inc.Apparatus and method for expanding a stimulation lead body in situ
US6458121 *Mar 19, 1996Oct 1, 2002Diapulse Corporation Of AmericaApparatus for athermapeutic medical treatments
US6460545Mar 1, 2001Oct 8, 2002Ep Technologies, Inc.Medical device with three dimensional collapsible basket structure
US6488673Jul 8, 1999Dec 3, 2002Broncus Technologies, Inc.Method of increasing gas exchange of a lung
US6488679Jul 26, 2000Dec 3, 2002Scimed Life Systems, Inc.Systems and methods for controlling power in an electrosurgical probe
US6493589Aug 10, 2000Dec 10, 2002Medtronic, Inc.Methods and apparatus for treatment of pulmonary conditions
US6494880Jul 26, 2000Dec 17, 2002Scimed Life Systems, Inc.Systems and methods for controlling power in an electrosurgical probe
US6496738Feb 6, 2001Dec 17, 2002Kenneth L. CarrDual frequency microwave heating apparatus
US6514246Jul 7, 1998Feb 4, 2003Ep Technologies, Inc.Systems and methods for forming large lesions in body tissue using curvilinear electrode elements
US6526320May 16, 2001Feb 25, 2003United States Surgical CorporationApparatus for thermal treatment of tissue
US6529756Nov 22, 1999Mar 4, 2003Scimed Life Systems, Inc.Apparatus for mapping and coagulating soft tissue in or around body orifices
US6544226Mar 13, 2000Apr 8, 2003Curon Medical, Inc.Operative devices that can be removably fitted on catheter bodies to treat tissue regions in the body
US6544262Feb 28, 2001Apr 8, 2003Ep Technologies, Inc.Structures and methods for deploying electrode elements
US6547788Mar 2, 2000Apr 15, 2003Atrionx, Inc.Medical device with sensor cooperating with expandable member
US6558378Dec 13, 2000May 6, 2003Cardiac Pacemakers, Inc.RF ablation system and method having automatic temperature control
US6572612Oct 11, 2001Jun 3, 2003Medtronic, Inc.Ablation catheter and method for isolating a pulmonary vein
US6575623Oct 1, 2001Jun 10, 2003Cardiostream, Inc.Guide wire having extendable contact sensors for measuring temperature of vessel walls
US6575969Aug 21, 2000Jun 10, 2003Sherwood Services AgCool-tip radiofrequency thermosurgery electrode system for tumor ablation
US6582427Mar 3, 2000Jun 24, 2003Gyrus Medical LimitedElectrosurgery system
US6582430Dec 6, 2001Jun 24, 2003Cardiac Pacemakers, Inc.Ablation catheter manipulation tool and method therefor
US6589235Jan 19, 2001Jul 8, 2003The Regents Of The University Of CaliforniaMethod and apparatus for cartilage reshaping by radiofrequency heating
US6610054Nov 27, 1996Aug 26, 2003Vidamed, Inc.Medical probe device and method
US6620159Jun 6, 2001Sep 16, 2003Scimed Life Systems, Inc.Conductive expandable electrode body and method of manufacturing the same
US6626903Apr 27, 2001Sep 30, 2003Rex Medical, L.P.Surgical biopsy device
US6634363Mar 27, 2000Oct 21, 2003Broncus Technologies, Inc.Methods of treating lungs having reversible obstructive pulmonary disease
US6635056Oct 9, 2001Oct 21, 2003Cardiac Pacemakers, Inc.RF ablation apparatus and method using amplitude control
US6638273Nov 27, 2000Oct 28, 2003Vnus Medical Technologies, Inc.Expandable catheter having improved electrode design, and method for applying energy
US6640120Oct 5, 2000Oct 28, 2003Scimed Life Systems, Inc.Probe assembly for mapping and ablating pulmonary vein tissue and method of using same
US6645200Mar 24, 2000Nov 11, 2003Scimed Life Systems, Inc.Method and apparatus for positioning a diagnostic or therapeutic element within the body and tip electrode for use with same
US6652548Mar 30, 2001Nov 25, 2003Bacchus Vascular Inc.Expansible shearing catheters for thrombus removal
US6669693Nov 13, 2001Dec 30, 2003Mayo Foundation For Medical Education And ResearchTissue ablation device and methods of using
US6673068Apr 12, 2000Jan 6, 2004Afx, Inc.Electrode arrangement for use in a medical instrument
US6692492Nov 28, 2001Feb 17, 2004Cardiac Pacemaker, Inc.Dielectric-coated ablation electrode having a non-coated window with thermal sensors
US6699243Sep 19, 2001Mar 2, 2004Curon Medical, Inc.Devices, systems and methods for treating tissue regions of the body
US6714822May 30, 2002Mar 30, 2004Medtronic, Inc.Apparatus and method for expanding a stimulation lead body in situ
US6723091Feb 22, 2001Apr 20, 2004Gyrus Medical LimitedTissue resurfacing
US6743197Jul 2, 1999Jun 1, 2004Novasys Medical, Inc.Treatment of discrete tissues in respiratory, urinary, circulatory, reproductive and digestive systems
US6749604Mar 30, 2000Jun 15, 2004Arthrocare CorporationElectrosurgical instrument with axially-spaced electrodes
US6749606Sep 4, 2001Jun 15, 2004Thomas KeastDevices for creating collateral channels
US6767347Feb 1, 2001Jul 27, 2004Oratec Interventions, Inc.Catheter for delivery of energy to a surgical site
US6770070Mar 17, 2000Aug 3, 2004Rita Medical Systems, Inc.Lung treatment apparatus and method
US6802843Sep 12, 2002Oct 12, 2004Csaba TruckaiElectrosurgical working end with resistive gradient electrodes
US6805131Aug 29, 2002Oct 19, 2004Ep Technologies, Inc.Medical device with three dimensional collapsible basket structure
US6837888Feb 25, 2002Jan 4, 2005Arthrocare CorporationElectrosurgical probe with movable return electrode and methods related thereto
US6840243Apr 18, 2003Jan 11, 2005Emphasys Medical, Inc.Methods and devices for use in performing pulmonary procedures
US6849073Apr 24, 2002Feb 1, 2005Medtronic, Inc.Apparatus and method for creating, maintaining, and controlling a virtual electrode used for the ablation of tissue
US6852091Apr 15, 2002Feb 8, 2005Medtronic Vidamed, Inc.Medical probe device and method
US6852110Aug 1, 2002Feb 8, 2005Solarant Medical, Inc.Needle deployment for temperature sensing from an electrode
US6866662Jul 23, 2002Mar 15, 2005Biosense Webster, Inc.Ablation catheter having stabilizing array
US6881213Oct 23, 2002Apr 19, 2005Ethicon, Inc.Device and method to expand treatment array
US6893436Jan 3, 2002May 17, 2005Afx, Inc.Ablation instrument having a flexible distal portion
US6893439Feb 18, 2003May 17, 2005Ep Technologies, Inc.Structures and methods for deploying electrode elements
US6895267Oct 24, 2001May 17, 2005Scimed Life Systems, Inc.Systems and methods for guiding and locating functional elements on medical devices positioned in a body
US6904303Dec 11, 2002Jun 7, 2005Boston Scientific Scimed, Inc.Apparatus for mapping and coagulating soft tissue in or around body orifices
US6917834Oct 10, 2001Jul 12, 2005Boston Scientific Scimed, Inc.Devices and methods for creating lesions in endocardial and surrounding tissue to isolate focal arrhythmia substrates
US6939346Jun 28, 2002Sep 6, 2005Oratec Interventions, Inc.Method and apparatus for controlling a temperature-controlled probe
US6954977Sep 23, 2002Oct 18, 2005Maguire Mark ACircumferential ablation device assembly and methods of use and manufacture providing an ablative circumferential band along an expandable member
US7027869Oct 25, 2001Apr 11, 2006Asthmatx, Inc.Method for treating an asthma attack
US7043307Aug 4, 2003May 9, 2006Boston Scientific Scimed, Inc.Device and method for treatment of gastroesophageal reflux disease
US7104987 *Apr 14, 2003Sep 12, 2006Asthmatx, Inc.Control system and process for application of energy to airway walls and other mediums
US7104990Nov 24, 2003Sep 12, 2006Boston Scientific Scimed, Inc.Loop structure including inflatable therapeutic device
US7118568Mar 31, 2003Oct 10, 2006St. Jude Medical, Atrial Fibrillation Division, Inc.Process and device for the treatment of atrial arrhythmia
US7122033Dec 10, 2003Oct 17, 2006The United States Of America As Represented By The Department Of Health And Human ServicesEndoluminal radiofrequency cauterization system
US7131445Dec 5, 2003Nov 7, 2006Gyrus Medical LimitedElectrosurgical method and apparatus
US7186251Feb 25, 2004Mar 6, 2007Cierra, Inc.Energy based devices and methods for treatment of patent foramen ovale
US7198635Apr 14, 2003Apr 3, 2007Asthmatx, Inc.Modification of airways by application of energy
US7200445Oct 21, 2005Apr 3, 2007Asthmatx, Inc.Energy delivery devices and methods
US7241295May 10, 2004Jul 10, 2007AstrionixCircumferential ablation device assembly and methods of use and manufacture providing an ablative circumferential band along an expandable member
US7255693Jan 27, 2003Aug 14, 2007Csa Medical, Inc.Heated catheter used in cryotherapy
US7264002Mar 26, 2004Sep 4, 2007Asthmatx, Inc.Methods of treating reversible obstructive pulmonary disease
US7266414Oct 22, 2004Sep 4, 2007Syntach, AgMethods and devices for creating electrical block at specific sites in cardiac tissue with targeted tissue ablation
US7273055Aug 13, 2003Sep 25, 2007Asthmatx, Inc.Methods of treating asthma
US7425212Nov 8, 1999Sep 16, 2008Asthmatx, Inc.Devices for modification of airways by transfer of energy
US7542802May 31, 2006Jun 2, 2009Asthmatx, Inc.Methods of regenerating tissue in airways
US7556624Aug 30, 2002Jul 7, 2009Asthmatx, Inc.Method of increasing gas exchange of a lung
US7740017Apr 29, 2005Jun 22, 2010Asthmatx, Inc.Method for treating an asthma attack
US20030050631Aug 2, 2002Mar 13, 2003Afx, Inc.Tissue ablation apparatus with a sliding ablation instrument and method
US20030065371Jun 18, 2002Apr 3, 2003Shutaro SatakeRadiofrequency thermal balloon catheter
US20030069570Nov 12, 2002Apr 10, 2003Witzel Thomas H.Methods for repairing mitral valve annulus percutaneously
US20030187430Mar 15, 2002Oct 2, 2003Vorisek James C.System and method for measuring power at tissue during RF ablation
US20030236455May 19, 2003Dec 25, 2003Scimed Life Systems, Inc.Probe assembly for mapping and ablating pulmonary vein tissue and method of using same
US20040010289Apr 14, 2003Jan 15, 2004Broncus Technologies, Inc.Control system and process for application of energy to airway walls and other mediums
US20040153056Nov 10, 2003Aug 5, 2004Berchtold Holding Gmbh, A German CorporationProbe
US20040249401May 14, 2004Dec 9, 2004Omnisonics Medical Technologies, Inc.Apparatus and method for an ultrasonic medical device with a non-compliant balloon
US20050010270Mar 26, 2004Jan 13, 2005Asthmatx, Inc.Method of treating airways in the lung
US20050096644Oct 30, 2003May 5, 2005Hall Jeffrey A.Energy delivery optimization for RF duty cycle for lesion creation
US20050171396Oct 19, 2004Aug 4, 2005Cyberheart, Inc.Method for non-invasive lung treatment
US20050193279Oct 22, 2004Sep 1, 2005Felix DanersDevice for monitoring medical equipment
US20050203503Jan 12, 2005Sep 15, 2005Rita Medical Systems, Inc.Infusion array ablation apparatus
US20050240176Jun 22, 2005Oct 27, 2005Regents Of The University Of MichiganAblation catheters
US20050251128Apr 20, 2005Nov 10, 2005Gyrus Medical LimitedElectrosurgical method and apparatus
US20060062808Sep 30, 2004Mar 23, 2006Asthmatx, Inc.Inactivation of smooth muscle tissue
US20060079887Oct 3, 2005Apr 13, 2006Buysse Steven PElectrosurgical system employing multiple electrodes and method thereof
US20060089637Jul 12, 2005Apr 27, 2006Werneth Randell LAblation catheter
US20060135953Dec 22, 2004Jun 22, 2006Wlodzimierz KaniaTissue ablation system including guidewire with sensing element
US20060137698Feb 23, 2006Jun 29, 2006Asthmatx, Inc.Methods for treating airways
US20060247617May 25, 2006Nov 2, 2006Asthmatx, Inc.Energy delivery devices and methods
US20060247618May 25, 2006Nov 2, 2006Asthmatx, Inc.Medical device with procedure improvement features
US20060247619May 25, 2006Nov 2, 2006Asthmatx, Inc.Medical device with procedure improvement features
US20060247727Jul 17, 2006Nov 2, 2006Asthmatx, Inc.Control system and process for application of energy to airway walls and other mediums
US20060247746Apr 21, 2006Nov 2, 2006Asthmatx, Inc.Control methods and devices for energy delivery
US20060254600Apr 4, 2006Nov 16, 2006Asthmatx, Inc.Methods for treating airways
US20060278243May 31, 2006Dec 14, 2006Asthmatx, Inc.Methods of treating inflammation in airways
US20060278244Jun 20, 2006Dec 14, 2006Asthmatx, Inc.Methods of reducing mucus in airways
US20060282071May 26, 2006Dec 14, 2006Utley David SMethod for Tissue Ablation
US20070074719Dec 8, 2006Apr 5, 2007Asthmatx, Inc.Control methods and devices for energy delivery
US20070083194Jun 20, 2006Apr 12, 2007Kunis Christopher GAblation catheter
US20070083197Dec 11, 2006Apr 12, 2007Asthmatx, Inc.Method for treating an asthma attack
US20070100390Sep 22, 2006May 3, 2007Asthmatx, Inc.Modification of airways by application of energy
US20070102011Nov 7, 2006May 10, 2007Asthmatx, Inc.Methods of evaluating individuals having reversible obstructive pulmonary disease
US20070106292Dec 29, 2006May 10, 2007Asthmatx, Inc.Energy delivery devices and methods
US20070106296Dec 19, 2006May 10, 2007Asthmatx, Inc.Expandable electode devices and methods of treating bronchial tubes
US20070106348Nov 22, 2006May 10, 2007Asthmatx, Inc.Method for treating airways in the lung
US20070118184Dec 21, 2006May 24, 2007Asthmatx, Inc.Devices for modification of airways by transfer of energy
US20070118190Dec 21, 2006May 24, 2007Asthmatx, Inc.Methods of treating asthma
US20070123958Nov 22, 2006May 31, 2007Asthmatx, Inc.Apparatus for treating airways in the lung
US20070123961Dec 28, 2006May 31, 2007Asthmax, Inc.Energy delivery and illumination devices and methods
US20070129720Nov 14, 2006Jun 7, 2007Ardian, Inc.Methods and apparatus for performing a non-continuous circumferential treatment of a body lumen
US20080004596May 25, 2007Jan 3, 2008Palo Alto InstituteDelivery of agents by microneedle catheter
US20080097424Oct 20, 2006Apr 24, 2008Asthmatx, Inc.Electrode markers and methods of use
US20080255642Jun 26, 2008Oct 16, 2008Ardian, Inc.Methods and systems for thermally-induced renal neuromodulation
US20090018538Jul 12, 2007Jan 15, 2009Asthmatx, Inc.Systems and methods for delivering energy to passageways in a patient
US20090030477Jul 24, 2008Jan 29, 2009Asthmatx, Inc.System and method for controlling power based on impedance detection, such as controlling power to tissue treatment devices
US20090043301Aug 8, 2008Feb 12, 2009Asthmatx, Inc.Monopolar energy delivery devices and methods for controlling current density in tissue
US20090069797Sep 8, 2008Mar 12, 2009Asthmatx, Inc.Bipolar devices for modification of airways by transfer of energy
US20090112203Dec 4, 2008Apr 30, 2009Asthmatx, Inc.Modification of airways by application of microwave energy
US20090143705Dec 4, 2008Jun 4, 2009Asthmatx, Inc.Modification of airways by application of ultrasound energy
US20090143776Dec 1, 2008Jun 4, 2009Asthmatx, Inc.Modification of airways by application of cryo energy
US20090192505Jul 30, 2009Reset Medical, Inc.Method for cryospray ablation
US20090192508Jul 30, 2009Asthmatx, Inc.Modification of airways by application of mechanical energy
US20090306644May 8, 2009Dec 10, 2009Innovative Pulmonary Solutions, Inc.Systems, assemblies, and methods for treating a bronchial tree
USRE35330Oct 13, 1993Sep 17, 1996University Of Kansas Medical CenterHot tip catheter assembly
DE19529634A1Aug 11, 1995Feb 13, 1997Otto Werner WoelkyInfrared heat irradiation in carcinoma treatment
EP189329A3 Title not available
EP280225A3 Title not available
EP282225B1 Title not available
EP286145A2 Title not available
EP286145A3 Title not available
EP768091B1 Title not available
EP908150A1 Title not available
EP0908713A1Oct 6, 1997Apr 14, 1999Claud S. Gordon CompanyTemperature instrumented semiconductor wafer
EP1297795B1Jun 18, 2002Aug 17, 2005Shutaro SatakeRadiofrequency thermal balloon catheter
FR2659240B1 Title not available
GB2233293A Title not available
GB2233293B Title not available
JP7289557A Title not available
JP9047518A Title not available
JP9243837A Title not available
JP10026709A Title not available
JP59167707A Title not available
RU2053814C1 Title not available
RU2091054C1 Title not available
SU545358A1 Title not available
WO1999003413A1Jul 17, 1998Jan 28, 1999Vnus Med Tech IncExpandable catheter having improved electrode design, and method for applying energy
WO2009082433A2Dec 5, 2008Jul 2, 2009Timothy AskewMethod for cryospray ablation
WO2009137819A1May 8, 2009Nov 12, 2009Innovative Pulmonary Solutions, Inc.Systems, assemblies, and methods for treating a bronchial tree
Non-Patent Citations
Reference
1An S. S., et al., "Airway smooth muscle dynamics: a common pathway of airway obstruction in asthma," European Respiratory Journal, 2007, 29 (5), 834-860.
2Bel, et al., ""Hot stuff": bronchial thermoplasty for asthma," American Journal of Respiratory and Critical Care Medicine, 2006, 173, 941-943.
3Brown R. H., et al., "Effect of bronchial thermoplasty on airway distensibility," European Respiratory Journal, 2005, 26 (2), 277-282.
4Brown R. H., et al., "In vivo evaluation of the effectiveness of bronchial thermoplasty with computed tomography," Journal of Applied Physiology, 2005, 98, 1603-1606.
5Chhajed P., et al., "Will there be a role for bronchoscopic radiofrequency ablation?," J Bronchol, 2005, 12 (3), 184-186.
6Co-pending U.S. Appl. No. 09/095,323, filed Jun. 10, 1998, Inventor Laufer et al.
7Co-pending U.S. Appl. No. 09/244,173, filed Feb. 4, 1999, Inventor Laufer et al.
8Co-pending U.S. Appl. No. 12/640,644, filed Dec. 17, 2009, Inventor Jerry Jarrard.
9Co-pending U.S. Appl. No. 12/727,156, filed Mar. 18, 2010, Inventor Danek et al.
10Co-pending U.S. Appl. No. 12/765,704, filed Apr. 22, 2010 Inventor Danek et al.
11Cox G., et al., "Asthma Control during the Year after Bronchial Thermoplasty," The New England journal of medicine, 2007, 356 (13), 1327-1337.
12Cox G., et al., "Bronchial Thermoplasty for Asthma," American Journal of Respiratory and Critical Care Medicine, 2006, 173, 965-969.
13Cox G., et al., "Bronchial Thermoplasty: Long-Term Follow-Up and Patient Satisfaction," Chest, 2004, 126 (4), 822s.
14Cox G., et al., "Bronchial Thermoplasty: One-Year Update, American Thoracic Society Annual Meeting," Am J Respir Crit Care Med, 2004, 169, A313.
15Cox G., et al., "Clinical Experience With Bronchial Thermoplasty for the Treatment of Asthma," Chest, 2003, 124, 106S.
16Cox G., et al., "Development of a Novel Bronchoscopic Therapy for Asthma," Journal of Allergy and Clinical Immunology, 2003, 113 (2), S33.
17Cox G., et al., "Early Clinical Experience with Bronchial Thermoplasty for the Treatment of Asthma, American Thoracic Society Annual Meeting," 2002, 1068.
18Cox G., et al., "Impact of bronchial thermoplasty on asthma status: interim results from the AIR trial.European Respiratory Society Annual Meeting. Munich, Germany," 2006, 1 page.
19Cox G., et al., "Radiofrequency ablation of airway smooth muscle for sustained treatment of asthma: preliminary investigations," European Respiratory Journal, 2004, 24, 659-663.
20Danek C. J., et al., "Asthma Intervention Research (AIR) Trial Evaluating Bronchial Thermoplasty(TM): Early Results, American Thoracic Society Annual Meeting," 2002, 1 page.
21Danek C. J., et al., "Asthma Intervention Research (AIR) Trial Evaluating Bronchial Thermoplasty™: Early Results, American Thoracic Society Annual Meeting," 2002, 1 page.
22Danek C. J., et al., "Bronchial thermoplasty reduces canine airway responsiveness to local methacholine challenge, American Thoracic Society Annual Meeting," 2002, 1 page.
23Danek C. J., et al., "Reduction in airway hyperresponsiveness to methacholine by the application of RF energy in dogs," J Appl Physiol, 2004, 97, 1946-1953.
24Dierkesmann, et al., "Indication and Results of Endobronchial Laser Therapy," Lung, 1990, 168, 1095-1102.
25Erle C. H., et al., "Botulinum toxin: a novel therapeutic option for bronchial asthma?," Medical Hypotheses, 2006, 66, 915-919.
26Hogg J. C., "The Pathology of Asthma," APMIS, 1997, 105 (10), 735-745.
27Ivanyuta O. M., et al., "Effect of Low-Power Laser Irradiation of Bronchial Mucosa on the State of Systemic and Local Immunity in Patients with Chronic Bronchitis," Problemy Tuberkuleza, 1991, 6, 26-29.
28James, et al., "The Mechanics of Airway Narrowing in Asthma," Am. Rev. Respir. Dis., 1989, 139, 242-246.
29Johnson S. R., et al., "Synthetic Functions of Airway Smooth Muscle in Asthma," Trends Pharmacol. Sci., 1997, 18 (8), 288-292.
30Julian Solway M. D., et al., "Airway Smooth Muscle as a Target for Asthma Therapy," The New England journal of medicine, 2007, 356 (13), 1367-1369.
31Kitamura S., "Color Atlas of Clinical Application of Fiberoptic Bronchoscopy," 1990, Year Book Medical Publishers, 17.
32Laviolette, et al., "Asthma Intervention Research (Air) Trial: Early Safety Assessment of Bronchial Thermoplasty," Am J Respir Crit Care Med, 2004, 169, A314.
33Leff, et al., "Bronchial Thermoplasty Alters Airway Smooth Muscle and Reduces Responsiveness in Dogs: A Possible Procedure for the Treatment of Asthma, American Thoracic Society Annual Meeting," 2002, 1 page.
34Lombard, et al., "Histologic Effects of Bronchial Thermoplasty of Canine and Human Airways, American Thoracic Society Annual Meeting," 2002, 1 page.
35Macklem P. T., "Mechanical Factors Determining Maximum Bronchoconstriction," European Respiratory Journal, 1989, 6, 516s-519s.
36Mayse M. L., et al., "Clinical Pearls for Bronchial Thermoplasty," J Bronchol, 2007, 14 (2), 115-123.
37Miller J. D., et al., "A Prospective Feasibility Study of Bronchial Thermoplasty in the Human Airway," 2005, 127, 1999-2006.
38Miller J. D., et al., "Bronchial Thermoplasty Is Well Tolerated By Non-Asthmatic Patients Requiring Lobectomy, American Thoracic Society Annual Meeting," 2002, 1 page.
39Netter F. H., "Respiratory System: A Compilation of Paintings Depicting Anatomy and Embryology, Physiology, Pathology, Pathophysiology, and Clinical Features and Treatment of Diseases,In The CIBA Collection of Medical Illustrations M.B. Divertie, ed., Summit: New Jerse," 1979, 7, 119-135.
40Notice of final Rejection, Japanese Patent Application No. 2000-553172, dated Sep. 2, 2008, 5 pages.
41PCT International search report for application No. PCT/US00/05412 mailed on Jun. 20, 2000, 2 pages.
42PCT International search report for application No. PCT/US00/18197 mailed on Oct. 3, 2000, 1 page.
43PCT International search report for application No. PCT/US00/28745 mailed on Mar. 28, 2001, 6 pages.
44PCT International search report for application No. PCT/US01/32321 mailed on Jan. 18, 2002, 2 pages.
45PCT International search report for application No. PCT/US98/03759 mailed on Jul. 30, 1998, 1 page.
46PCT International search report for application No. PCT/US98/26227 mailed on Mar. 25, 1999, 1 page.
47PCT International search report for application No. PCT/US99/00232 mailed on Mar. 4, 1999, 1 page.
48PCT International search report for application No. PCT/US99/12986 mailed on Sep. 29, 1999, 1 page.
49Provotorov, et al., "The Clinical Efficacy of Treating Patients with Nonspecific Lung Disease by Using Low-energy Laser Irradiation and Intrapulmonary Drug Administration, ISSN: 0040-3660," Terapevticheskii Arkhiv (USSR), 1991, 62 (12), 18-23.
50Rubin, et al., "Bronchial thermoplasty improves asthma status of moderate to severe perisstent asthmatics over and above current standard-of-care, American College of Chest Physicians," 2006, 2 pages.
51Shesterina M. V., et al., "Effect of laser therapy on immunity in patients with bronchial asthma and pulmonary tuberculosis," 1993, 23-26.
52Sterk P. J., et al., "Heterogeneity of airway hyperresponsiveness: time for unconventional, but traditional, studies," J Appl Physiol, 2004, 96, 2017-2018.
53Toma, et al., "Brave new world for interventional bronchoscopy," Thorax, 2005, 60, 180-181.
54Trow T., "Clinical Year in Review I Diagnostic Imaging, Asthma, Lung Transplantation, and Interventional Pulmonology," Proceedings of the American Thoracic Society, 2006, 3, 553-556.
55Vorotnev, et al., "Low energy laser treatment of chronic obstructive bronchitis in a general rehabilitation center,ISSN: 0040-3660," Terapevticheskii Arkhiv, 1997, 69 (3), 17-19.
56Wayne Mitzner, "Airway Smooth Muscle The appendix of the Lung," American Journal of Respiratory and Critical Care Medicine, 2004, 169, 787-790.
57Wiggs B. R., et al., "On the Mechanism of Mucosal Folding in Normal and Asthmatic Airways," J. Appl. Physiol., 1997, 83 (6), 1814-1821.
58Wilson S. R., et al., "Global assessment after bronchial thermoplasty: the patients perspective," Journal of Outcomes Research, 2006, 10, 37-46.
59Wizeman, et al., "A Computer Model of Thermal Treatment of Airways by Radiofrequency (RF) Energy Delivery, American Thoracic Society Annual Meeting," 2007, 1 page.
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US8740895Jun 28, 2013Jun 3, 2014Holaira, Inc.Delivery devices with coolable energy emitting assemblies
US8777943Jun 28, 2013Jul 15, 2014Holaira, Inc.Delivery devices with coolable energy emitting assemblies
US8911439Nov 11, 2010Dec 16, 2014Holaira, Inc.Non-invasive and minimally invasive denervation methods and systems for performing the same
US8932289Sep 26, 2011Jan 13, 2015Holaira, Inc.Delivery devices with coolable energy emitting assemblies
US8951251Nov 7, 2012Feb 10, 2015Boston Scientific Scimed, Inc.Ostial renal nerve ablation
US9005195Sep 26, 2011Apr 14, 2015Holaira, Inc.Delivery devices with coolable energy emitting assemblies
US9017324Jun 28, 2013Apr 28, 2015Holaira, Inc.Delivery devices with coolable energy emitting assemblies
US9037259Dec 21, 2012May 19, 2015Vessix Vascular, Inc.Methods and apparatuses for remodeling tissue of or adjacent to a body passage
US9050106Dec 21, 2012Jun 9, 2015Boston Scientific Scimed, Inc.Off-wall electrode device and methods for nerve modulation
US9060761Nov 9, 2011Jun 23, 2015Boston Scientific Scime, Inc.Catheter-focused magnetic field induced renal nerve ablation
US9072902Dec 21, 2012Jul 7, 2015Vessix Vascular, Inc.Methods and apparatuses for remodeling tissue of or adjacent to a body passage
US9079000Oct 16, 2012Jul 14, 2015Boston Scientific Scimed, Inc.Integrated crossing balloon catheter
US9084609Jul 18, 2011Jul 21, 2015Boston Scientific Scime, Inc.Spiral balloon catheter for renal nerve ablation
US9089350Nov 9, 2011Jul 28, 2015Boston Scientific Scimed, Inc.Renal denervation catheter with RF electrode and integral contrast dye injection arrangement
Classifications
U.S. Classification606/34, 606/41, 607/102
International ClassificationA61N1/40, A61B18/10, A61N1/06, A61B18/14
Cooperative ClassificationA61B18/14, A61N1/40, A61B2018/00541, A61N1/06
European ClassificationA61N1/40, A61N1/06
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