|Publication number||US7922695 B2|
|Application number||US 11/874,417|
|Publication date||Apr 12, 2011|
|Filing date||Oct 18, 2007|
|Priority date||Oct 18, 2007|
|Also published as||EP2198164A1, US8377004, US8936574, US20090105650, US20110152827, US20130123749, WO2009049894A1|
|Publication number||11874417, 874417, US 7922695 B2, US 7922695B2, US-B2-7922695, US7922695 B2, US7922695B2|
|Inventors||Christopher Wiegel, Marco De Polo, Steven Roe|
|Original Assignee||Roche Diagnostics Operations, Inc.|
|Export Citation||BiBTeX, EndNote, RefMan|
|Patent Citations (32), Non-Patent Citations (4), Referenced by (3), Classifications (26), Legal Events (6)|
|External Links: USPTO, USPTO Assignment, Espacenet|
The present invention is generally related to drug delivery pumps, and in particular to a drug delivery pump drive using a linear piezoelectric motor to advance a syringe piston to deliver a liquid drug.
Typically miniature drug delivery pumps use an electric motor and a system of many gears to reduce the high speed motors down to a slower speed. The slower speed provides the precision needed to control the very small doses of a liquid drug being delivered by means of an advancing lead screw and nut moving the syringe piston. Due to the above performance requirements, such miniature drug delivery pump use an expensive high quality electric motor and the associated high quality gears, therefore making such pumps expensive and generally not disposable in nature. In addition, concealment under clothing is problematic due to the relative size of the motor and the noise generated during operation.
It is against the above background that the present invention provides a drug delivery pump drive which uses a linear piezoelectric motor to advance a syringe piston to deliver a liquid drug. The pump drive, provided in a drug delivery pump, provides silent operation and very low energy consumption compared to electric motor-based drives. The small size of the motor helps also to reduce overall size of the pump drive and the resulting drug deliver pump.
In one embodiment, a drive system used to dispense a liquid drug from a drug container having a piston is disclosed. The drive system comprises a lead screw having a rotational axis and operably connected to the piston; a ratchet wheel provided along the rotational axis and operably connected to the lead screw to rotate the lead screw about the rotational axis; a piezoelectric motor having a shaft, a nut engaging the shaft, and piezoelectric elements configured to produce reciprocating linear and rotational motion of the shaft relative to the nut adjacent the rotational axis; and a pawl operably connected to the shaft and engaging the ratchet wheel such that the reciprocating linear motion of the shaft is converted into unidirectional rotary motion of the ratcheted wheel about the rotational axis which moves the lead screw and advances the piston to dispense the liquid drug from the drug container. Completion of the cycle may be confirmed either by sensing the motor shaft has reached the limits of its travel or by the successful advancement of the ratchet by one tooth.
In another embodiment, a method for dispensing a liquid drug from a drug container having a piston is disclosed. The method comprises providing a lead screw having a rotational axis and operably connected to the piston; providing a ratchet wheel along the rotational axis and operably connected to the lead screw to rotate the lead screw about the rotational axis; providing a piezoelectric motor having a shaft, a nut engaging the shaft, and piezoelectric elements configured to produce reciprocating linear motion of the shaft relative to the nut adjacent the rotational axis; and providing a pawl operably connected to the shaft and engaging the ratchet wheel such that the reciprocating linear motion of the shaft is converted into unidirectional rotary motion of the ratcheted wheel about the rotational axis which moves the lead screw, wherein moving the lead screw advances the piston dispensing the liquid drug from the drug container.
Another embodiment discloses a drive system in which the motor shaft is held to rotate but not translate while the motor body is allowed to translate but not rotate. The drive system comprises a lead screw having a rotational axis and operably connected to the piston; a piezoelectric motor having a threaded shaft, a threaded motor body engaging the shaft, and piezoelectric elements configured to produce reciprocating linear and rotational motion of the shaft relative to the nut; a housing to constrain the shaft to rotate while constraining the motor body to translate; a connection between the motor shaft and lead screw to transmit the rotational movement of the shaft to the lead screw; a nut engaging the lead screw and operably connected to the piston; whereby as the motor is activated, the shaft outputs only rotary motion which causes the nut to advance along the lead screw, advancing the piston and dispensing liquid drug from the drug container.
These and other features and advantages of the invention will be more fully understood from the following description of various embodiments of the invention taken together with the accompanying drawings.
The following detailed description of the various embodiments of the present invention can be best understood when read in conjunction with the following drawings, where like structure is indicated with like reference numerals and in which:
In the following description of the embodiments of the invention, skilled artisans appreciate that elements in the figures are illustrated for simplicity and clarity and have not necessarily been drawn to scale. For example, the dimensions of some of the elements in the figures may be exaggerated relative to other elements to help to improve understanding of embodiment(s) of the present invention. Accordingly, the drawings are merely schematic representations, intending to depict only typical embodiments of the invention, and therefore should not be considered as limiting the scope of the invention. The invention will be described with additional specificity and detail through the accompanying drawings. The description of the invention may contain, for example, such descriptive terms as up, down top, bottom, right or left. These terms are meant to provide a general orientation of the parts of the invention and are not meant to be limiting as to the scope of the invention.
With reference to
In use, the application of a drive signal 14 from a controller 16 via wires 18 causes piezoelectric elements 20 in the motor 12 to vibrate or be driven through a range of motion which includes friction between contacting and constrained motor members, such as a threaded rod or shaft 22 and a motor body 24 which acts like a nut 25. In particular, the friction generated between the shaft 22 and the motor body 24, which houses the piezoelectric elements 20, causes the shaft 22 to rotate about the motor body 24, thereby producing the linear movement of the shaft 22 relative to the motor body 24. As the motor body 24 in the illustrated embodiment is fixed to a base 26 within a drug delivery or infusion pump 28, the shaft 22 will advance and apply a force axially (i.e. pushing) in either direction (e.g., up and down) depending on the drive signal 14. In one embodiment, the push force applied by the shaft is about 2 Newtons using a 100 VAC RMS sinusoidal drive signal.
In the illustrated embodiment of
A ratchet wheel 42 is located coaxially and fixed at an end of the lead screw 30. The ratchet wheel 42 and/or the lead screw 30 is mounted rotatably and coaxially to the cam 38. A pair of pawls 44, 46 allows the ratchet wheel 42 to be rotated in only one direction designated by symbol Z about the rotational axis X. The first pawl 44 is mounted at a first end 48 to the cam 38 and is located adjacent the ratchet wheel 42 such that a free end 50 of the first pawl 44 cooperates with the saw-like teeth 52 of the ratchet wheel 42. The second pawl 46 is fixed at first end 54, such as for example, to the base 26, and located also adjacent the ratchet wheel 42 such that a free end 56 cooperated with the teeth 52 of the ratchet wheel 42 and prevents the ratchet wheel from freely rotating in the opposite direction to the direction Z.
In the provided drive arrangement of the first illustrated embodiment, it is apparent that the oscillating (e.g., up and down) movement of the shaft 22 of the motor 12 about the motor body 24 causes the incrementing of the ratchet wheel 42 one tooth at a time. The tooth-by-tooth rotation of the ratchet wheel 42 causes the lead screw 30 to also rotate about the rotational axis X. As shown, the lead screw 30 is only free to rotate and is prevented from translating axially. A threaded nut 58 engages the lead screw 30.
The threaded nut 58 is provided with a projection or key portion 60 which is situated in a slot or keyway 62 that is mounted, for example, to the base 26. In this manner, the nut is prevented by the keyway 62 from rotating about the rotational axis X with the ratchet wheel 42 and lead screw 30 but is free to translate incrementally along axis X. The incremental advancement of the threaded nut 58 along the keyway 62 causes a plunger or piston 64 to be pushed into a syringe-like drug cartridge or container 66. The pushing of the piston 64, via incremental advancement of the nut 58, causes a liquid drug to be expelled from the container 66 in a controlled manner.
The rocker 80 mounts the first pawl 44 such that as the motor 12 oscillates the rocker 80 back and forth around the rotational axis X, the first pawl 44 rotates the ratchet wheel 42 in the advancing direction Z. The second pawl 46 is mounted or otherwise fixed to the base 26 such that the ratchet wheel 42 cannot rotate in the direction opposite to the advancing direction Z. In this embodiment, the lead screw 30 is fixed to rotate with the ratchet wheel 42. It is to be appreciated that in another embodiment, the lead screw 30 and ratchet wheel 42 may be a unitary piece. For brevity, as the pump drive 300 advances the piston 64 in the same manner as described above with reference to the pump drive 100 shown by
Another embodiment of a pump drive 400 is shown by
Still another embodiment of a pump drive 500 is shown by
In the illustrated embodiment shown by
In all the illustrative pump drive embodiments shown by
As shown by
In the illustrated embodiment shown by
Although not limited to, some of the noted advantages of the present invention are as follows: the inherent precision of the motion from the piezoelectric motor which can be used to accurately deliver very small doses (i.e., about 100 mL), nearly silent operation, fewer moving parts, and smaller parts. Such advantages result in an overall compact and low cost drug delivery pump for the consumer.
The foregoing description of the invention has been presented for purposes of illustration and description. It is not intended to be exhaustive or to limit the invention to the precise form disclosed, and other modifications and variations may be possible in light of the above teachings. The above embodiments disclosed were chosen and described to explain the principles of the invention and its practical application to thereby enable others skilled in the art to best utilize the invention. It is intended that the appended claims be construed to include other alternative embodiments of the invention except insofar as limited by the prior art.
|Cited Patent||Filing date||Publication date||Applicant||Title|
|US3745843 *||Apr 14, 1972||Jul 17, 1973||Omega Brandt & Freres Sa Louis||Motion transformer|
|US3868861 *||Jan 14, 1974||Mar 4, 1975||Scholin Ind Inc||Stepping motor|
|US3903436 *||Feb 20, 1974||Sep 2, 1975||Mansei Kogyo Kk||Piezoelectric generating device|
|US3970420 *||Oct 16, 1974||Jul 20, 1976||Mansei Kogyo Kabushiki Kaisha||Actuating arrangements for a cigarette lighter|
|US4169984 *||Nov 30, 1976||Oct 2, 1979||Contract Systems Associates, Inc.||Ultrasonic probe|
|US4685903 *||Jan 6, 1984||Aug 11, 1987||Pacesetter Infusion, Ltd.||External infusion pump apparatus|
|US4760939 *||Apr 24, 1986||Aug 2, 1988||Jencons (Scientific) Limited||Liquid dosing device with digital display|
|US4871939 *||Dec 21, 1987||Oct 3, 1989||Emhart Industries, Inc.||Piezoelectric motor|
|US5237236||Nov 16, 1992||Aug 17, 1993||Rockwell International Corporation||Walking toothed actuator|
|US5562015 *||Jun 14, 1995||Oct 8, 1996||Zinck; Frederick L.||Automatic ratchet reversal device|
|US6147435||Mar 15, 1999||Nov 14, 2000||Central Gikenkogyo Corporation||Mechanism for driving a screw rod by supersonic vibration|
|US6203528||Mar 30, 1999||Mar 20, 2001||Baxter International Inc.||Unitary molded elastomer conduit for use with a medical infusion pump|
|US6249717||Jun 2, 1997||Jun 19, 2001||Sangstat Medical Corporation||Liquid medication dispenser apparatus|
|US6375638||Feb 12, 1999||Apr 23, 2002||Medtronic Minimed, Inc.||Incremental motion pump mechanisms powered by shape memory alloy wire or the like|
|US6656158||Apr 23, 2002||Dec 2, 2003||Insulet Corporation||Dispenser for patient infusion device|
|US6723072||Jun 6, 2002||Apr 20, 2004||Insulet Corporation||Plunger assembly for patient infusion device|
|US6726678||Feb 22, 2001||Apr 27, 2004||Isurgical, Llc||Implantable reservoir and system for delivery of a therapeutic agent|
|US6811548||Apr 1, 1997||Nov 2, 2004||Peter Jeffrey||Materials delivery device|
|US6940209||Sep 8, 2003||Sep 6, 2005||New Scale Technologies||Ultrasonic lead screw motor|
|US7119478 *||Feb 11, 2004||Oct 10, 2006||Honeywell Federal Manufacturing & Technologies, Llc||Piezoelectric step-motion actuator|
|US7170214||Jun 14, 2005||Jan 30, 2007||New Scale Technologies, Inc.||Mechanism comprised of ultrasonic lead screw motor|
|US7193521||Oct 22, 2003||Mar 20, 2007||Medtronic Minimed, Inc.||Method and apparatus for detecting errors, fluid pressure, and occlusions in an ambulatory infusion pump|
|US7456550 *||Aug 1, 2007||Nov 25, 2008||Roche Diagnostics Operations, Inc.||Drive unit for medical devices|
|US20040220551||Apr 30, 2003||Nov 4, 2004||Flaherty J. Christopher||Low profile components for patient infusion device|
|US20050177111||Feb 6, 2004||Aug 11, 2005||Shaul Ozeri||Miniature infusion pump|
|US20080051711 *||Nov 22, 2006||Feb 28, 2008||Medtronic Minimed, Inc.||Infusion medium delivery device and method with drive device for driving plunger in reservoir|
|US20080097326 *||Oct 27, 2006||Apr 24, 2008||Medtronic Minimed, Inc.||Infusion medium delivery device and method with drive device for driving plunger in reservoir|
|US20080269570 *||Apr 25, 2007||Oct 30, 2008||The Hong Kong Polytechnic University||Medical device for delivering drug and/or performing physical therapy|
|US20090124994 *||Nov 8, 2007||May 14, 2009||Roe Steven N||Miniature drug delivery pump with a piezoelectric drive system|
|DE102005004498A1||Feb 1, 2005||Aug 10, 2006||Roche Diagnostics Gmbh||Antrieb für medizinische Geräte|
|WO2002071592A2||Mar 1, 2002||Sep 12, 2002||Stanford Res Inst Int||Electroactive polymer rotary motors|
|WO2008024808A2||Aug 22, 2007||Feb 28, 2008||Medtronic Minimed Inc||Portable infusion pumps of the skin-patch type|
|1||Internet Archive Wayback Machine record of New Scale Technologies Webpage, http://www.web.archive.org/web/*/http://www.newscaletech.com/nonmagnetic.html, Mar. 28, 2007.|
|2||Lopez, Jose F., "Modeling and Optimizationof Ultrasonic Linear Motors", Ecole Polytechnique Federale De Lausane, These No. 3665 (2006)|
|3||Newscale Technologies Webpage, htttp://www.newscaletech.com/nonmagnetic.html, 2006.|
|4||Preliminary Report on Patentability, Application PCT/EP2008/008791, Date of Issuance of this report Apr. 20, 2010, 10 pages.|
|Citing Patent||Filing date||Publication date||Applicant||Title|
|US8177749||May 20, 2008||May 15, 2012||Avant Medical Corp.||Cassette for a hidden injection needle|
|US8535268 *||Dec 22, 2010||Sep 17, 2013||Alcon Research, Ltd.||Device for at least one of injection or aspiration|
|US20120165783 *||Apr 28, 2011||Jun 28, 2012||Barry Lynn Wheatley||Device for at least one of injection or aspiration|
|U.S. Classification||604/155, 310/311, 604/31, 310/328, 604/165.04, 604/107, 604/211, 604/209, 604/156, 604/134, 604/108, 604/151, 604/256|
|Cooperative Classification||F04B43/095, A61M5/14244, A61M5/14566, F04B17/003, F04B43/046, A61M2205/8212, A61M5/14216|
|European Classification||A61M5/142P, F04B43/04M2, F04B17/00P, A61M5/145B12, F04B43/09P|
|Jan 4, 2008||AS||Assignment|
Owner name: ROCHE DIAGNOSTICS OPERATIONS, INC., INDIANA
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:WIEGEL, CHRISTOPHER;DE POLO, MARCO;ROE, STEVEN;REEL/FRAME:020316/0486
Effective date: 20071022
|Mar 25, 2008||AS||Assignment|
Owner name: DISETRONIC LICENSING AG, SWITZERLAND
Free format text: ASSIGNMENT OF AN UNDIVIDED ONE-HALF INTEREST;ASSIGNOR:ROCHE DIAGNOSTICS OPERATIONS, INC.;REEL/FRAME:020694/0648
Effective date: 20080319
|Apr 8, 2011||AS||Assignment|
Owner name: ROCHE DIAGNOSTICS INTERNATIONAL AG, SWITZERLAND
Free format text: MERGER;ASSIGNOR:DISETRONIC LICENSING AG;REEL/FRAME:026094/0743
Effective date: 20090508
|Sep 13, 2011||CC||Certificate of correction|
|Sep 24, 2014||FPAY||Fee payment|
Year of fee payment: 4
|Jun 23, 2015||AS||Assignment|
Owner name: ROCHE DIABETES CARE, INC., INDIANA
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:ROCHE DIAGNOSTICS OPERATIONS, INC.;REEL/FRAME:036008/0670
Effective date: 20150302