US 7975703 B2
Methods and apparatus for delivering precise amounts of fluid under pressure into cardiac tissue for the purpose of facilitating ablation of the tissue along a desired lesion line. One method injects fluid under pressure through a discharge orifice in a needle-less injection device. The injected fluid can be a cytotoxic fluid and/or a highly conductive fluid injected in conjunction with radio frequency ablation to create an ablative virtual electrode. The injected fluid can provide deeper and narrower conduction paths and resulting lesions. Radio frequency ablation can be performed at the same time as the fluid injection, using the injection device as an electrode, or subsequent to the fluid injection, using a separate device. In some methods, the injected fluid is a protective fluid, injected to protect tissue adjacent to the desired lesion line. Fluid delivery can be endocardial, epicardial, and epicardial on a beating heart. The present methods find one use in performing maze procedures to treat atrial fibrillation.
1. A method for ablation of myocardial tissue comprising:
providing a needle-less hand-held instrument having a first discharge orifice open through a tissue contacting surface for injecting fluid under pressure into myocardial tissue, the needle-less hand-held instrument also comprising a first electrode and a second electrode having opposite polarities to form a bi-polar electrode pair located on the tissue contacting surface and relative to the first discharge orifice with the first discharge orifice in between the electrode pair;
selecting a desired line of ablation on a surface of the tissue;
applying the first discharge orifice to the tissue at a portion of the desired line of ablation; and
delivering a predetermined amount of pressurized fluid into the myocardial tissue to facilitate ablation of the tissue along the desired ablation line
after delivering the pressurized fluid, applying ablative electrical energy across the electrode pair to the myocardial tissue along the desired ablation line.
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The present application is a divisional of U.S. patent application Ser. No. 10/356,909, filed on Feb. 3, 2003, now U.S. Pat. No. 7,118,566 which claims the benefit of U.S. provisional patent application Ser. No. 60/381,217, filed on May 16, 2002, titled DEVICE AND METHOD FOR ABLATION OF CARDIAC TISSUE, herein incorporated by reference in its entirety. The present application is related to commonly assigned U.S. patent application Ser. No. 10/356,868, filed on Feb. 3, 2003, titled DEVICE AND METHOD FOR ABLATION OF CARDIAC TISSUE.
The present invention relates generally to the field of devices for cardiac surgery, and more specifically to devices for ablation of cardiac tissue.
The present invention is directed toward treatment of tachyarrhythmias, which are heart rhythms in which one or more chambers of the heart exhibit an excessively fast rhythm. In particular, the present invention is directed toward treatment of tachycardias, which are due to the presence of ectopic foci within the cardiac tissue or due to the presence of aberrant condition pathways within the cardiac tissue.
There are many medical treatments that involve instances of cutting, ablating, coagulating, destroying, or otherwise changing the physiological properties of tissue. These techniques can be used beneficially to change the electrophysiological properties of tissue. For example, ablation of cardiac tissue can be used to cure various cardiac conditions. Normal sinus rhythm of the heart begins with the sinoatrial node (or “SA node”) generating a depolarization wave front. The impulse causes adjacent myocardial tissue cells in the atria to depolarize, which in turn causes adjacent myocardial tissue cells to depolarize. The depolarization propagates across the atria, causing the atria to contract and empty blood from the atria into the ventricles. The impulse is next delivered via the atrioventricular node (or “AV node”) and the bundle of HIS (or “HIS bundle”) to myocardial tissue cells of the ventricles. The depolarization of these cells propagates across the ventricles, causing the ventricles to contract. This conduction system results in the described, organized sequence of myocardial contraction leading to a normal heartbeat.
Sometimes aberrant conductive pathways develop in heart tissue, which disrupt the normal path of depolarization events. For example, anatomical obstacles in the atria or ventricles can disrupt the normal propagation of electrical impulses. These anatomical obstacles (called “conduction blocks”) can cause the electrical impulse to degenerate into several circular wavelets that circulate about the obstacles. These wavelets, called “reentry circuits,” disrupt the normal activation of the atria or ventricles.
The aberrant conductive pathways create abnormal, irregular, and sometimes life-threatening heart rhythms, called arrhythmias. An arrhythmia can take place in the atria, for example, as in atrial tachycardia, atrial fibrillation or atrial flutter. The arrhythmia can also take place in the ventricle, for example, as in ventricular tachycardia.
The lesions used to treat atrial fibrillation, are typically long and thin and are carefully placed to interrupt the conduction routes of the most common reentry circuits. More specifically, the long thin lesions are used to create a maze pattern that creates a convoluted path for electrical propagation within the left and right atria. The lesions direct the electrical impulse from the SA node along a specified route through all regions of both atria, causing uniform contraction required for normal atrial transport function. The lesions finally direct the impulse to the AV node to activate the ventricles, restoring normal atrioventricular synchrony. Several surgical approaches have been developed with the intention of treating atrial fibrillation. One particular example is known as the “maze procedure,” as is disclosed by Cox, J L et al. in “The surgical treatment of atrial fibrillation. I. Summary” Thoracic and Cardiovascular Surgery 101(3), pp. 402-405 (1991); and also by Cox, J L in “The surgical treatment of atrial fibrillation. IV. Surgical Technique”, Thoracic and Cardiovascular Surgery 101(4), pp. 584-592 (1991), both of which are incorporated by reference herein in their entireties. In general, the “maze” procedure is designed to relieve atrial arrhythmia by restoring effective atrial systole and sinus node control through a prescribed pattern of incisions about the tissue wall. In the early clinical experiences reported, the “maze” procedure included surgical incisions in both the right and the left atrial chambers. However, more recent reports predict that the surgical “maze” procedure may be substantially efficacious when performed only in the left atrium, such as is disclosed in Sueda et al., “Simple Left Atrial Procedure for Chronic Atrial Fibrillation Associated With Mitral Valve Disease” (1996), which is incorporated herein by reference in its entirety.
When modifying the electrophysiological properties of cardiac tissue by ablation, or by other means of destroying tissue to create lesions, physicians must carefully place the lesions. Otherwise, tissue will be unnecessarily destroyed. In addition, the heart is in close proximity to nerves and other nervous tissue and the destruction of this tissue will result in severe harm to the patient. Anatomical methods are used to locate the areas to be ablated or otherwise modified. In other words, the physician locates key structures such as the mitral valve annulus and the pulmonary veins. Lesions are typically formed that block propagations near these structures. Additional lesions are then formed which connect these lesions and complete the so-called “maze pattern.” However, the exact lesion pattern, and number of lesions created, can vary from patient to patient.
The surgical “maze procedure” as performed in the left atrium generally includes forming vertical incisions from the two superior pulmonary veins and terminating in the region of the mitral valve annulus, traversing the inferior pulmonary veins en route. An additional horizontal line also connects the superior ends of the two vertical incisions. Thus, the atrial wall region bordered by the pulmonary vein ostia is isolated from the other atrial tissue. In this process, the mechanical sectioning of atrial tissue eliminates the precipitating conduction to the atrial arrhythmia by creating conduction blocks within the aberrant electrical conduction pathways.
Injection of alcohol into heart tissue has also been employed to ablate cardiac tissue. Alcohol may be delivered to blood vessels supplying the tissue to be ablated, as described in “Transcoronary Chemical Ablation of Arrhythmias”, by Nellens et al, Pace Vol. 15, pages 1368-1373, September 1992. Alternatively, alcohol can be delivered directly to the tissue to be ablated by means of a needle inserted through a catheter, as described in “Chemical Ablation by Subendocardial Injection of Ethanol via Catheter—Preliminary Results in the Pig Heart”, by Weismuller et al, European Heart Journal, Volume 12, pages 1234-1239, 1991.
Although successful at treating AF, the surgical maze procedure is quite complex and is currently performed by only a few skilled cardiac surgeons in conjunction with other open-heart procedures. Tools that could reliably duplicate the Maze incisions by other means (e.g. radio frequency, laser, microwave, ultrasound energy) will reduce the time and invasiveness required for the maze procedure and make it more accessible to more surgeons. Problems faced by these methods, however, include (a) the creation of continuous, linear lesions in the atria for the prevention of atrial fibrillation, (b) minimization of clotting and thromboembolism, (c) the effect of heat loss due to circulating blood, (d) minimization of lesion width and minimization of atrial debulking, (e) conforming to an irregular myocardial thickness, (f) adaptability to a variety of lesion geometries and (g) usefulness from either the endocardial surface of an open heart, or the epicardial surface of a beating heart.
The present invention includes devices and methods for ablation of cardiac tissue in which a hand-held, needle-less injector is used to deliver precise amounts of liquid under pressure into cardiac tissue for purposes of ablation of the tissue along a desired lesion line. The liquids can be cytotoxic, protective, and/or conductive and can optionally be used in conjunction with RF current ablation and/or photochemically activated. The injection under pressure can deeply and narrowly ablate cardiac tissue, and can transmurally ablate cardiac tissue entirely through the myocardium when delivered from either the epicardial or the endocardial surface. The needle-less injector device can be a modification of those used for mass vaccinations.
In one embodiment of the invention, the fluid that is injected into the tissue is photo-chemically activated. Light energy can be applied slightly before, during, or after injection of the fluid into the tissue. The distal head of the injection device can incorporate fiber optic electrodes capable of transmitting the appropriate wavelength of energy to the tissue to activate the cytotoxic property of the fluid. Photo-chemically activated fluids are well known, having been used in chemotherapy.
One needle-less, tissue ablative, injector device includes a cylindrical housing having a lumen within for containing a fluid, an electrically conductive distal surface operably coupled to the housing for contacting tissue, and at least one discharge orifice near the electrically conductive surface and in fluid communication with the fluid lumen. The device can also include a pressure applicator in communication with the fluid lumen for imparting sufficient pressure to the fluid lumen to inject the fluid into the myocardium from the epicardial or endocardial surface. A pressure applicator switch operably coupled to the pressure applicator can impart pressure to eject fluid through the discharge orifice when the pressure applicator switch is activated. An electrical connector in electrical continuity with the tissue contacting surface can provide ablative electrical energy to the tissue contacting surface.
Some needle-less tissue ablative injector devices also include a radio-frequency current source electrically coupled to the device electrical connector. Other needle-less injector devices include a fluid supply connector coupled to the fluid lumen. The pressure applicator can include a reciprocating piston slidably disposed within at least part of the fluid lumen. In some devices, a spring urges the piston distally. In other devices, a gas pressure source acts on the piston to move the piston distally. The distal motion of the piston within the fluid lumen can impart high pressure to the fluid in the lumen, forcing the fluid out the discharge orifice and into the tissue.
Needle-less injector devices can also include a distal tip coupled to the device distal region and can have at least one discharge orifice disposed in the tip. The tip can include a fluid lumen coupling the device fluid lumen and the tip discharge orifices, with the tissue contacting surface located on the tip, such that fluid can be injected through at least two discharge orifices simultaneously. In some devices the tip is removable.
Other needle-less injector devices also include an electrical switch electrically coupled to the electrical connector for controllably providing radio frequency energy to the tissue, with the electrical switch being coupled to the pressure applicator switch. Devices can have a two-position trigger configured to first change the state of the pressure applicator switch, and subsequently change the state of the electrical switch. The two-position trigger can cause conductive fluid to be injected into the tissue, followed by application of ablative electrical energy deeply into the tissue, conducted in part by the injected conductive solution.
In one aspect of the invention, a needle-less injector is used to repeatedly penetrate cardiac tissue with fluid under pressure and to deliver a cytotoxic agent into the cardiac tissue. The cytotoxic agent is used to “draw” a lesion on the myocardium by the repeated injection of cytotoxic fluid while moving the tip of the device along the desired lesion pattern. Because of the repeated and rapid injection, the surgeon can complete the lesion pattern rapidly. In some devices, a manually operated switch on the housing of the device activates the pressure applicator as desired by the operator and repeatedly injects fluid under pressure from the device. The fluid pressure can be adjusted to control the depth at which the cytotoxic fluid is delivered to the tissue. The imparted fluid pressure can enable the cytotoxic fluid to be injected into the tissue so that it extends transmurally, through the entire thickness of the tissue. The fluid can be bulk loaded into a fluid reservoir in the device for multiple injections or can be loaded into a “single shot” lumen and repeatedly replenished from an external fluid source. The fluid delivery can be performed endocardially, and/or epicardially on a stopped heart, and/or epicardially on a beating heart.
In yet another aspect of the invention, a device as described above is utilized in combination with radio frequency ablation. The device tissue contacting surface can be connected to one pole of a radio frequency generator while the other pole of the generator is connected to a large indifferent electrode.
In still another aspect of the present invention, the injection head includes two electrodes to create a bipolar ablation device. The electrodes can reside on the surface or penetrate the tissue, using needles for example. The distal ablation head is small in some embodiments, having discrete point or short linear electrodes and only one or a small number of injection orifices. In other embodiments, the ablation head includes longer linear electrodes and a larger number of injection orifices.
Rather than a cytotoxic agent, the high-pressure device can deliver a conductive liquid such as a saline solution that creates an ablative virtual electrode when delivered into the tissue through high pressure. The device is advanced along a desired lesion line on the tissue as the fluid is injected into the tissue. Delivery of the conductive liquid and the ablative radio frequency energy can be synchronized to form the virtual electrode and ablate the tissue along the desired lesion line.
In another aspect of the invention, a device as described above is utilized in combination with a conventional radio frequency ablation device such as the Cardioblate® pen sold by Medtronic, Inc. Rather than a cytotoxic agent, pressure injection delivers a conductive liquid such as a hypertonic saline solution to the tissue. The device is advanced along a desired lesion line on the tissue as the fluid is injected into the tissue. Delivery of the conductive liquid is made into the tissue along the desired lesion line. The conductive tip of the Cardioblate pen is subsequently drawn along the desired lesion line while applying radio frequency energy to the tissue. The hypertonic saline solution that creates a low impedance electrical pathway to ground such that the resultant lesion is deeper and narrower than would normally result from the use of the conventional radio frequency ablation device.
In yet another aspect of the invention, a device as described above is utilized in order to deliver a protective fluid in order to protect certain areas of cardiac tissue, such as tissue near vessels and valves. For example, a hypotonic fluid can be used as a protective fluid in order to increase the electrical impedance of the tissue to be protected relative to the surrounding tissues, essentially insulating the protected tissue from the electrical current of the radio frequency ablation device. This aspect of the invention can be combined with one or more of the other aspects of the invention in which a conductive liquid is delivered to a first portion of cardiac tissue along a desired lesion line and a protective fluid is delivered to a second portion of cardiac tissue spaced apart from the desired lesion line. This can be readily accomplished by a device having a plurality of spaced-apart discharge orifices with centrally located orifices delivering the conductive liquid and other orifices on one or both sides of the centrally located orifices delivering the protective fluid. As the radio frequency ablation device, such as the Cardioblate pen, is advanced along the desired lesion line, a narrower and deeper lesion will result with this technique.
In still another aspect of the invention, a device as described above is utilized in order to deliver an ink or dye to the cardiac tissue in order to identify the position of the lesion line on the cardiac tissue and to identify portions of tissue along the lesion line where the lesion has been completed. For example, the ink or dye can be added to the cytotoxic fluid in order to identify portions of tissue that have received the cytotoxic fluid, and to insure that those portions create a complete lesion along the desired lesion line. Alternatively, the ink or dye can be added to the conductive liquid in order to identify the portions of tissue that have been ablated by the radio frequency energy of a virtual electrode. The completeness of the lesion line is again indicated by the presence of the ink or dye. Alternatively, the ink or dye can be added to the conductive liquid in order to identify the position of the desired lesion line so that the Cardioblate pen or other radio frequency ablation device can be guided along the line that has been established by the delivery of the conductive fluid. In yet another aspect, the ink or dye can be thermochromic such that it changes color when heated to a temperature, which indicates that a lesion has been formed by the application of radio frequency energy. Typically, temperatures above about 50 to 55 degrees C. are required to cause cell death in an ablative lesion made by radio frequency ablation and the thermochromic material would preferably change color in that temperature range.
Other means to drive fluid into tissue can also be used with the present invention. One method includes the use of ultrasound, for example high intensity focused ultra sound (HIFU), to drive a fluid, for example saline, into the tissue. With the addition of a secondary energy source to the device, photophoresis or iontophoresis can be used to help drive fluid into the tissue. If desired, photophoresis and/or iontophoresis may be used alone to drive fluid into the tissue, since photophoresis and/or iontophoresis do not themselves require high-pressure injection.
The following detailed description should be read with reference to the drawings, in which like elements in different drawings are numbered identically. The drawings, which are not necessarily to scale, depict selected embodiments and are not intended to limit the scope of the invention. Several forms of the invention have been shown and described, and other forms will now be apparent to those skilled in art. It will be understood that embodiments shown in drawings and described below are merely for illustrative purposes, and are not intended to limit the scope of the invention as defined in the claims, which follow.
Needle-less fluid injector 20 can also include an optional electrical connector 40. Electrical connector 40 can be any suitable electrical connector, including banana plug connectors, screw terminals, spade lugs, jacks, or jack receptacles, as well as other electrical connectors well-known to those skilled in the art. Electrical connector 40 is preferably electrically coupled to tissue contacting surface 29.
Fluid can be injected into tissue through discharge orifice 28 while the tissue is contacted by tissue contacting surface 29. Tissue contacting surface 29 can be electrically conductive and in electrical continuity with electrical connector 40. Tissue contacting surface 29 can be part of a distal nozzle region disposed about discharge orifice 28 in some embodiments, and be electrically coupled to electrical connector 40. In another set of embodiments, discharge orifice 28 is coupled to a tip. In this embodiment, the tip itself bears the tissue contacting surface and contains a fluid discharge orifice for injecting fluid under pressure into the tissue.
Tissue contacting surface 77 of nozzle 72 also includes a first polarity electrode 78 and a second polarity electrode 79. Electrodes 78 and 79 can be either relatively short linear electrodes as illustrated in
A shaft 134 is shown in
The operation of needle-less injector device 120 can be visualized with respect to
Shaft 134 can be proximally retracted in various ways in various embodiments. In the embodiment illustrated in
Trigger manually operable portion 135 can be pulled, thereby urging trigger actuator end 133 against split-nut actuator end 141, to urge split-nut actuator 142 against biasing spring 143. Split-nut actuator 142 thus opens split nut 144 to disengage shaft threaded portion 138, leaving retention rack teeth 155 engaged by pawl 170. As trigger 132 is further depressed, trigger actuator end 133 can engage piston retainer cam region 172 to pivot piston retainer 146 about pivot 174 and thereby disengage pawl 170 from teeth 155. Spring 152 can now drive piston 150 against the fluid contained within fluid lumen 140 to force the fluid through discharge orifice 164. In other embodiments, knob 128 can be replaced by a lever-cam device, for rapidly retracting shaft 134 in a single motion.
In embodiments utilizing only a cytotoxic fluid, and not utilizing radio frequency (RF) ablation, a device performing the functions of needle-less injector device 120 may be sufficient to form a lesion along the desired lesion line. In embodiments utilizing RF ablation, an external RF ablation source can be connected to electrical connector 168 to supply tissue-contacting surface 162 with radio frequency ablation energy. In some devices, an external trigger or switch is used to control the application of radio frequency ablation energy to the tissue. In other embodiments, an electrical switch can be operably coupled to trigger 132, such that the action of trigger 132 triggers both the fluid injection and the application of radio frequency ablating energy to the tissue. The application of radio frequency energy to the tissue can be slightly delayed to allow the injection of fluid into the tissue prior to the application of the radio frequency energy.
A high-pressure gas source or cylinder 280 may be seen within handle 236. High pressure gas source 280 is coupled to a valve body 282 having a valve channel 286 therethrough reversibly blocked by a valve stem or plug 288. Valve plug 288 is coupled to a tension biasing spring 290 to maintain the valve plug in the closed position. A trigger 232 may be seen including a lever arm 235 pivotally mounted about pivot point 233. Lever arm 235 is coupled to valve plug 288 through a rod 292. Valve body 282 is a coupled to a piston 262 through a gas channel 270. Piston 262 can be slidably and sealingly disposed within fluid lumen 234.
Needle-less injection device 220 can also include an electrical line 296 coupled to distal tip 208 at 297 and to tissue contacting surface 206. Electrical line 296 is also connected to a lumen contacting electrode 295. Devices can have the electrical source in contact with the tissue contacting surface, a conductive fluid within the fluid lumen, or both. Electrical line 296 is coupled through an electrical switch 237 to a second electrical line 241 which is in turn electrically coupled to an electrical connector 240. Electrical connector 240, as previously discussed with respect to connector 40 of
In use, fluid can be supplied by fluid source 272, through fluid coupling 273, and through check valve 270 into fluid lumen 234, thereby forcing piston 262 proximally away from distal tip 208, and filling fluid lumen 234 with fluid. Distal tip 208 can be disposed against tissue 221 and trigger 232 depressed to a first position, moving valve plug 288 out of valve channel 286 to allow high pressure gas to flow from high pressure gas source 280 through gas channel 270 to drive piston 262 against fluid contained in fluid lumen 234. The driving piston 262 thus forces fluid out of fluid lumen 234, through fluid discharge orifice 228, and into tissue 221. Trigger 232 can then be depressed to a second, more depressed position to close electrical switch 237, providing radio frequency ablative energy to tissue contacting surface 206. Ablative electrical energy can thus be provided to the tissue region recently injected with fluid. As previously discussed, the fluid can be a conductive fluid, thus forming a virtual electrode in the tissue.
Many presently available vaccination guns can be used to practice one aspect of the present invention. Specifically, applicants believe that presently available vaccination guns can be used to inject cytotoxic fluids into the myocardial tissue as well as other tissues to be injected with cytotoxic fluids. Presently available vaccination guns may also be used by modifying the guns to provide ablative, radio frequency energy at or near the distal, tissue contacting surface or tip. Some vaccination guns can be modified by adding an electrical connector electrically coupled to the conductive, distal tip. An external radio frequency energy source can then be connected to the gun electrical connector to practice the ablative, radio frequency energy aspect of the present invention to form tissue legions in the target tissue.
The depth of penetration of the fluid injected can be adjusted to match the target tissue thickness and the desired degree of penetration. In myocardial applications, it may be desirable to have the fluid penetrate at least about halfway through the tissue thickness without penetrating entirely through the tissue thickness. In some methods, the fluid pressure can be set to effect transmural penetration. The penetration depth can be controlled by adjusting the pressure applied by the pressure applicator. In mechanical embodiments of the present invention, the pressure may be adjusted by varying the degree of compression supplied to a spring within the needle-less injector device. In gas-operated embodiments, the pressure may be varied by regulating the gas pressure supplied at the piston. In one embodiment of the invention, an ultrasonic transducer can be mounted near the device distal end to provide an indication of tissue thickness near the tip, and the fluid penetration depth set as a function of the indication of tissue thickness.
The cytotoxic agents referred to in the present application are agents that have cytotoxic properties and can be delivered as injectable liquids or as liquid suspensions. Preferably, a cytotoxic substance has potent cytotoxic properties that destroy cell function without affecting protein structure and scaffolding. The cytotoxic agent also preferably has limited and controllable diffusion properties through extracellular spaces. Also, the cytotoxic agent preferably has a fleeting effect such that the compound washes out of the systemic circulation quickly. Alkylating agents such as cytotoxin or melphalan or their active metabolites are preferred.
A protective fluid can also be used when making the linear lesions 110 in order to protect certain areas of cardiac tissue, such as tissue near vessels and valves like the pulmonary veins 116. For example, a hypotonic fluid can be used as a protective fluid in order to increase the electrical impedance of the tissue to be protected relative to the surrounding tissues, essentially insulating the protected tissue from the electrical current of the radio frequency ablation device. Alternatively, the protective fluid can be a thermally protective fluid such as a chilled fluid, which protects tissue adjacent to the intended lesion from being overheated. This aspect of the invention can be combined with one or more of the other aspects of the invention in which a conductive liquid is delivered to a first portion of cardiac tissue along a desired lesion line and a protective fluid is delivered to a second portion of cardiac tissue spaced apart from the desired lesion line. This can be readily accomplished by a device having a plurality of spaced-apart discharge orifices with centrally located orifices delivering the conductive liquid and other orifices on one or both sides of the centrally located orifices. As the radio frequency ablation device, such as the Cardioblate pen, is advanced along the desired lesion line a narrower and deeper lesion would result with this technique.
Also, the device as described above can be utilized in order to deliver an ink or dye to the cardiac tissue in order to identify the position of the lesion line 110 on the cardiac tissue and to identify portions of tissue along the lesion line 110 where the lesion has been completed. For example, the ink or dye can be added to the cytotoxic fluid in order to identify portions of tissue which have received the cytotoxic fluid and that those portions create a complete lesion along the desired lesion line. Alternatively, the ink or dye can be added to the conductive liquid in order to identify the portions of tissue, which has been ablated by the radio frequency energy of a virtual electrode. Again the completeness of the lesion line is indicated by the presence of the ink or dye. Alternatively, the ink or dye can be added to the conductive liquid in order to identify the position of the desired lesion line so that the Cardioblate pen or other radio frequency ablation device can be guided along the line that has been established by the delivery of the conductive fluid. Dyes such as those used for tattoos are believed suitable, as are some tissue dyes. Toluene blue and methylene blue are examples of dyes believed suitable for use in the present invention.
In yet another aspect, the ink or dye can be thermochromic such that it changes color when heated to a temperature, which indicates that a lesion has been formed by the application of radio frequency energy. Typically, temperatures above about 50 to 55 degrees C. are required to cause cell death in an ablative lesion made by radio frequency ablation and the photochromic material would preferably change color in that temperature range.
In still another aspect, the injected fluid can include a viscosity enhancing agent or fluid added to reduce or retard fluid diffusion after delivery. Reducing the diffusion of a cytotoxic and/or conductive fluid can reduce the width of the resulting lesion. Reducing the diffusion of a protective fluid can maintain the protective fluid in a desired position adjacent the cytotoxic and/or conductive fluid, to serve its protective function. Viscous fluids such as dextrose or glycerol may be added to increase the viscosity of a delivered fluid. The viscous fluids or agents can provide a fluid viscosity of at least about twice that of water.
In still another aspect, the delivery of ionized fluids may be enhanced via a small current applied across two electrodes, i.e., iontophoresis. For example, a small current applied between the conductive distal tip 208 of needle-less injection device 220 and the ground electrode can enhance the movement within tissue of ionized fluid delivered from the fluid discharge orifice 228. As an alternative to a mono-polar configuration, a bi-polar configuration could be used. For example, a small current may be applied between electrode 78 of nozzle 72 and electrode 79 of nozzle 72. As described above, electrodes 78 and 79 can be either relatively short linear electrodes as illustrated in
It will be appreciated by those skilled in the art that while the invention has been described above in connection with particular embodiments and examples, the invention is not necessarily so limited, and that numerous other embodiments, examples, uses, modifications and departures from the embodiments, examples and uses are intended to be encompassed by the claims attached hereto. The entire disclosure of each patent and publication cited herein is incorporated by reference, as if each such patent or publication were individually incorporated by reference herein.