|Publication number||US8101204 B2|
|Application number||US 12/687,295|
|Publication date||Jan 24, 2012|
|Filing date||Jan 14, 2010|
|Priority date||Jan 14, 2010|
|Also published as||US20110171293|
|Publication number||12687295, 687295, US 8101204 B2, US 8101204B2, US-B2-8101204, US8101204 B2, US8101204B2|
|Inventors||Karl Wei Cao|
|Original Assignee||Karl Wei Cao|
|Export Citation||BiBTeX, EndNote, RefMan|
|Patent Citations (13), Non-Patent Citations (1), Referenced by (3), Classifications (7), Legal Events (1)|
|External Links: USPTO, USPTO Assignment, Espacenet|
The present embodiments generally relate to hard capsules produced in two pieces as empty capsules manufactured solely by using vegetable derivatives.
A need exists for a capsule that does not include gelatin or other substances elicited from animals due to the dangerous associate with gelatin and other substances elicited from animals. For example, the dangers associated with gelatin or other substances elicited from animals can include BSE (bovine spongiform encephalitis).
A further need exists for a capsule that is made from seven completely natural ingredients including water in a biphasic solution system that is maintained at a temperature of no more than 80 degrees Fahrenheit.
A need further exists for a capsule that is made from a moisture locking procedure that gives the vegetarian hard capsule a novel mechanical and dimensional stability, allowing the hard capsules the ability to be filled with extremely hygroscopic material, without crosslinking
The present embodiments meet these needs.
Before explaining the present invention in detail, it is to be understood that the invention is not limited to the particular embodiments and that it can be practiced or carried out in various ways.
The present embodiments relate to a biphasic system for manufacturing clear hard vegetarian gelatin free two piece capsules, using a conventional dipping method.
The disclosed compositions do not employ mammalian gelatin and, therefore, overcome the disadvantages associated with animal-derived material. Compositions of the invention do not contain any gelatin but, instead, require at least seven agents: 1) a cellulose and 2) a gum derivative and 3) a metallic element and 4) a maltol extract and 5) a seaweed extract and 6) a galactomannan extract and 7) a water.
One or more embodiments of the method can be used to make a clear hard vegetarian gelatin free two piece capsule.
The method can include making a first phase of the biphasic network system. Making the first phase can include using a seaweed extract, a maltol extract, a metallic element, a gum derivative and a water.
A second phase or filler can also be created by blending water, a galactomannan extract, and a cellulose ether at a temperature less than 80 Fahrenheit.
The filler can be mixed into the first phase network system forming a biphasic system or blend while maintaining a temperature of not more than 80 degrees Fahrenheit.
One or more first moulding pins or large diameter moulding pins can be dipped into the biphasic system or blend while maintaining the biphasic system or blend at a temperature of not more than 80 degrees Fahrenheit.
One or more second moulding pin or small diameter moulding pins can also be dipped into the blend or biphasic system while maintaining the blend or biphasic system at a temperature of not more then 80 degrees Fahrenheit.
The second moulding pin can have a diameter that is from about 1.0 percent to about 10.0 percent less than the diameter of the first moulding pin.
The dipped moulding pins can be put into a chamber with a humidity that is no more than about 25 percent and the water can be blown away from an outer surface of dipped moulding pins. The water can be blown away using blown hot air. The blown hot air can be at a temperature from about 70 degrees Celsius to about 77 degrees Celsius, thereby bonding or locking the water to the cellulose, rendering each capsule piece to have an outer surface resistant to humidity and moisture, while maintaining a brilliantly clear, mechanically and dimensionally stable hard capsule resistant to crosslinking and hygroscopic material. The clear hard vegetarian gelatin free two piece capsule surprisingly inhibits microbial activity by bonding or locking of the water to the cellulose of the clear hard vegetarian gelatin free two piece capsule upon drying.
The biphasic system produces a clear hard vegetarian gelatin free two piece capsule wherein a dosage amount can be inserted between the first and second capsule pieces. The first and second capsule pieces can be joined together with an interference fit forming a dosage capsule that resists cracking, brittleness, and some storage conditions, caused by the hot air blown onto the wet capsule, and bonding the moisture to the cellulose until a water activity measures from about 0.10 to about 0.60.
The cellulose of the biphasic system for the clear hard vegetarian gelatin free two piece capsule can be a methyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose hydroxyethylmethyl cellulose, hydroxyethylethyl cellulose, hydroxypropylmethyl cellulose, cotton cellulose, or combinations thereof.
The seaweed extract for making a clear hard vegetarian gelatin free two piece capsule can be carrageenan, red seaweed, brown seaweed, funoran algae, red algae, brown algae, green algae, kelp, other marine plants, or combinations thereof.
The maltol extract can be crystalline and can be used for making a clear hard vegetarian gelatin free two piece capsule can be larch bark, pine needles, chicory and roasted malt, or combinations thereof.
The metallic element for making a clear hard vegetarian gelatin free two piece capsule can be potassium, magnesium, calcium, iron, or combinations thereof.
The gellan gum can be polysaccharides.
The galactomannan extract can be mannan, locust bean gum, carob, carob gum, carob bean gum, carboin, guar gum, tragacanth gum, or combinations thereof.
In one or more embodiments a crystalline alcohol can be added to the filler. The crystalline alcohol can be dextrose, glucose, sorbitol, manitol, fructose, fruit sugar derivative alcohols, or combinations thereof.
The clear hard vegetarian gelatin free two piece capsule can have gellan gum at a weight percent from about 0.5 to about 5.0, the seaweed exact at a weight percent from about 0.01 to about 5.0;, a metallic element at weight percent from about 0.01 to about 5.0, a maltol extract at weight percent from about 0.05 to about 12.0, the galatomannan extract at a weight percent from about 0.05 to about 5.0, the cellulose derivative at a weight percent from about 15.0 to about 45.0, and from about 60.0 to about 90.0 weight percent of water.
The clear hard vegetarian gelatin free two piece capsule can be a suppository or an oral dosage capsule.
The clear hard vegetarian gelatin free two piece capsule can have a dosage amount. The dosage amount can be a liquid or an oil, such as marine oil, a lipid, a vitamin, synthetic, a vegetable, or combinations thereof.
In one or more embodiments, the dosage amount can be a dry botanical ingredient, botanical, marine extract, a vitamin supplement, or combinations thereof.
The dosage amount can be a dry or liquid pharmaceutical dosage amount that can be aspirin, antihistamine, acetaminophen, an anti-inflammatory, or an antibiotic, or combinations thereof.
The dosage amount can be a nutritional dosage amount.
The clear hard vegetarian gelatin free two piece capsule can also contain a flavoring additive added to the filler, the first phase network, or combinations thereof. The flavorings can include citrus flavoring, mint flavoring, rum flavoring, fruit flavoring, bubblegum flavoring, vanilla flavoring, chocolate flavoring, licorice flavoring, coffee flavoring, or combinations thereof.
The clear hard vegetarian gelatin free two piece capsule can also have an edible coloring added to the first phase network, the filler or combinations thereof. The edible coloring can be azoquinophthalone triphenylmethane, xanthene, indigoid dyes, iron oxides, iron hydroxides, titanium dioxides, carbon black, riboflavin, carotenes, anthocyanines, tumeric, cochineal extracts, chlorophyllin, canthaxanthin, caramel, betannin, or combinations thereof.
The clear hard vegetarian gelatin free two piece capsule can also have a coating or banding. The coating or banding can be a polysaccharide or a second cellulose.
While these embodiments have been described with emphasis on the embodiments, it should be understood that within the scope of the appended claims, the embodiments might be practiced other than as specifically described herein.
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|US9408858||Apr 17, 2015||Aug 9, 2016||Opko Renal, Llc||Method for treating secondary hyperparathyroidism in CKD|
|US9498486||Aug 8, 2016||Nov 22, 2016||Opko Renal, Llc||Method for controlled release oral dosage of a vitamin D compound|
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|U.S. Classification||424/451, 424/453|
|Cooperative Classification||A61K9/4883, A61K9/4816|
|European Classification||A61K9/48B, A61K9/48P|