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Publication numberUSH811 H
Publication typeGrant
Application numberUS 07/322,460
Publication dateAug 7, 1990
Filing dateMar 13, 1989
Priority dateMar 11, 1988
Also published asCN1036879A, DE337103T1, DE68904792D1, DE68904792T2, EP0337103A2, EP0337103A3, EP0337103B1
Publication number07322460, 322460, US H811 H, US H811H, US-H-H811, USH811 H, USH811H
InventorsRikuo Nasu, Terumasa Komyoji, Toshio Nakajima, Kazumi Suzuki, Keiichiro Ito, Tekeshi Ohshima, Hideshi Yoshimura
Original AssigneeIshihara Sangyo Kaisha Ltd.
Export CitationBiBTeX, EndNote, RefMan
External Links: USPTO, USPTO Assignment, Espacenet
Biocidal composition
US H811 H
Abstract
A biocidal composition containing, as active ingredients, at least one imidazole compound represented by formula (I): ##STR1## wherein R1 represents a phenyl group, a halogen-substituted phenyl group, an alkyl group, or a halogen-substituted alkyl group; and R2 represents a halogen atom, and at least one other specific compound. The combination of the compound represented by formula (I) and other specific compound can produce an unexpected effect in amount required and biocidal spectrum.
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Claims(3)
What is claimed is:
1. A biocidal composition containing, as active ingredients, at least one imidazole compound represented by formula (I): ##STR10## wherein R1 represents a phenyl group, a halogen-substituted phenyl group, an alkyl group, or a halogen-substituted alkyl group; and R2 represents a halogen atom, and at least one compound selected from the group consisting of azole compounds, quinoxaline compounds, dithiocarbamate compounds, organic chlorine compounds, benzimidazole compounds, pyridinamine compounds, cyanoacetamide compounds, phenylamide compounds, sulfenic acid compounds, copper compounds, isoxazole compounds, organophosphorus compounds, N-halogenothioalkyl compounds, dicarboximide compounds, benzanilide compounds, benzamide compounds, piperazine compounds, pyridine compounds, pyrimidine compounds, piperidine compounds, morpholine compounds, organotin compounds, urea compounds, cinnamic acid compounds, carbamate compounds, pyrethroid compounds, benzoylurea compounds, thiazolidine compounds, thiadiazine compounds, nereistoxin derivatives, pyridazinone compounds, and spores of Bacillus thuringiensis and crystalline toxin produced thereby.
2. A biocidal composition as claimed in claim 1, wherein the imidazole compound is represented by formula (I'): ##STR11## wherein R1 ' represents a phenyl group or a halogen-substituted alkyl group; and R2 ' represents a chlorine atom.
3. A biocidal composition as claimed in claim 1, wherein the compound which is used in admixture with the imidazole compounds represented by formula (I) is at least one compound selected from the group consisting of azole compounds, quinoxaline compounds, dithiocarbamate compounds, organic chlorine compounds, benzimidazole compounds, pyridinamine compounds, cyanoacetamide compounds, phenylamide compounds, sulfenic acid compounds, copper compounds, isoxazole compounds, organophosphorus compounds, dicarboximide compounds, benzanilide compounds, and benzamide compounds.
Description
FIELD OF THE INVENTION

This invention relates to a biocidal composition containing as active ingredients at least one imidazole compound of formula (I) shown below and at least one other specific compound.

BACKGROUND OF THE INVENTION

The imidazole compounds of formula (I) shown below are useful as a biocide for controlling harmful organisms, which were found by the inventors of the present invention as described in European Patent 298,196A.

On the other hand, most of the compounds which are to be combined with the imidazole compounds of formula (I) have already been known to be effective as a fungicide, an insecticide, etc.

The imidazole compounds of formula (I) and many other biocides so far proposed each produces the respective characteristic biocidal effects on the respective objects. Some of them exert insufficient biocidal effects on specific harmful organisms, or some of them produce slightly inferior curative effects as compared with their preventive effects, or some of them are relatively short in their residual effect. Hence, the biocidal effects exhibited by these biocides on harmful organisms are sometimes unsatisfactory for practical utility depending on the occasion of application.

SUMMARY OF THE INVENTION

In the light of the above-described problem, the inventors of the present invention have conducted extensive investigations and, as a result, it has now been found that a combination of the imidazole compound represented by formula (I) shown below and other specific biocidal compound brings about unexpected results such as reduced amount of each compound to be used and enlarged biocidal spectrum of each compound as compared with the use of each compound alone.

The present invention relates to a biocidal composition for controlling harmful organisms containing, as active ingredients, at least one imidazole compound represented by formula (I): ##STR2## wherein R1 represents a phenyl group, a halogen-substituted phenyl group, an alkyl group, or a halogen-substituted alkyl group; and Rz represents a halogen atom, and at least one compound selected from the group consisting of azole compounds, quinoxaline compounds, dithiocarbamate compounds, organic chlorine compounds, benzimidazole compounds, pyridinamine compounds, cyanoacetamide compounds, phenylamide compounds, sulfenic acid compounds, copper compounds, isoxazole compounds, organophosphorus compounds, N-halogenothioalkyl compounds, dicarboximide compounds, benzanilide compounds, benzamide compounds, piperazine compounds, pyridine compounds, pyrimidine compounds, piperidine compounds, morpholine compounds, organotin compounds, urea compounds, cinnamic acid compounds, carbamate compounds, pyrethroid compounds, benzoylurea compounds, thiazolidine compounds, thiadiazine compounds, nereistoxin derivatives, pyridazinone compounds, and spores of Bacillus thurinqiensis and crystalline toxin produced thereby.

DETAILED DESCRIPTION OF THE INVENTION

In formula (I), the halogen atom includes fluorine, chlorine, bromine, and iodine atoms.

Further, in formula (I), the alkyl group contains from 1 to 4 carbon atoms and mention may be made of, for example, methyl group, ethyl group, n-propyl group, isopropyl group, n-butyl group, sec-butyl group, isobutyl group, tert-butyl group, etc.

As to the present invention, preferred embodiments are illustrated below.

(1) A biocidal composition wherein the compound which is used in admixture with the imidazole compounds represented by formula (I) is at least one compound selected from the group consisting of azole compounds, quinoxaline compounds, dithiocarbamate compounds, organic chlorine compounds, benzimidazole compounds, pyridinamine compounds, cyanoacetamide compounds, phenylamide compounds, sulfenic acid compounds, copper compounds, isoxazole compounds, organophosphorus compounds, dicarboximide compounds, benzanilide compounds, and benzamide compounds.

(2) A biocidal composition wherein the compound which is used in admixture with the imidazole compounds represented by formula (I) is at least one compound selected from the group consisting of 1-[N-(4-chloro-2-trifluoromethylphenyl)-2-propoxyacetimidoyl]imidazale [triflumizole], 6-methyl-1,3-dithiolo[4,5-b]quinoxalin-2-one [chinomethionate], a complex of zinc and manganese ethylenebis(dithiocarbamate) [mancozeb], tetrachloroisophthalonitrile [chlorothalonil], methyl 1-(butyl-carbamoyl)benzimidazol-2-yl carbamate [benomyl], 3-chloro-N-(3-chloro-2,6-dinitro-4-α,α,α-trifluorotolyl)-5-trifluoromethyl-2-pyridinamine [fluazinam], 1-(2- cyano-2-methoxyiminoacetyl)-3-ethylurea [cymoxanil], methyl N-(2-methoxyacetyl)-N-(2,6-xylyl)-DL-alaninate [metalaxyl], 2-methoxy-N-(2-oxo-1,3-oxazolidin-3-yl)- acet-2',6'-xylidide [oxadixyl], N-dichlorofluoro- methylthio-N',N'-dimethyl-N-phenylsulphamide [dichlofluanid], copper hydroxide [copper hydroxide], 5-methyl- isoxazol-3-ol [hydroxyisoxazole], aluminum tris(ethyl phosphonate) [fosetyl-Al], N-(3,5-dichlorophenyl)-1,2-dimethylcyclopropane-1,2-dicarboximide [procymidone], α,α,α-trifluoro-3'-isopropoxy-o-toluanilide [flutolanil], and (RS)-4-chloro-N-[cyano(ethoxy)methyl]benzamide.

(3) A biocidal composition wherein the imidazole compound is represented by formula (I'): ##STR3## wherein R1 ' represents a phenyl group or a halogen-substituted alkyl group; and R2 ' represents a chlorine atom.

(4) A biocidal composition whose main use is for a fungicide.

The imidazole compounds represented by formula (I) include compounds represented by formula (I-a) and/or compounds represented by formula (I-b): ##STR4##

Typical examples of the imidazole compounds of formula (I) are shown in Table 1 below.

              TABLE 1______________________________________ ##STR5##                      (I)Compound                      PhysicalNo.*      R1      R2                         Property______________________________________A-lb      phenyl       C1     m.p. 109-112 C.A-2b      2-chlorophenyl                  Cl     m.p. 113-117 C.A-3       2-fluorophenyl                  Cl     m.p. 96-101 C.A-4       4-chlorophenyl                  Cl     m.p. 108 C.A-5b      ethyl        Cl     m.p. 95-97 C.A-6b      n-propyl     Cl     m.p. 64-66 C.A-7b      n-butyl      Cl     m.p. 48-49 C.A-8b      n-propyl     Br     m.p. 93-94 C.A-9b      3-fluroropropyl                  Cl     m.p. 75-79 C.A-10b     3-brompropyl Cl     m.p. 79-84 C.A-11b     4-chlorobutyl                  Cl     nD 22.1 1.5382A-12b     3-chloropropyl                  Cl     m.p. 102-105 C.A-13b     2-chloroethyl                  Cl     m.p. 92-94 C.______________________________________ Note: *The compounds having compound numbers with a mark "b" are included under the formula (Ib) and those with no mark are mixtures of compounds under the formulae (Ia) and (Ib).

Examples of the compounds which can be used in combination with the imidazole compounds of formula (I) are tabulated below.

______________________________________Compound                     CommonNo.     Compound Name        Name______________________________________Azole Compounds:B-1     1-(4-Chlorophenoxy)-3,3-di-                        Triadimefon   methyl-1-(1H-1,2,4-triazol-1-   yl)butanoneB-2     1-(Biphenyl-4-yloxy)-3,3-di-                        Bitertanol   methyl-1-(1H-1,2,4-triazol-1-yl)-   butan-2-olB-3     1-[N-(4-Chloro-2-trifluoromethyl-                        Triflumizole   phenyl)-2-propoxyacetimidoyl]-   imidazoleB-4     1-[2-(2,4-Dichlorophenyl)-4-                        Etaconazole   ethyl-1,3-dioxolan-2-ylmethyl]-   1H-1,2,4-triazoleB-5     1-[2-(2,4-Dichlorophenyl)-4-                        Propiconazole   propyl-1,3-dioxolan-2-ylmethyl]-   1H-1,2,4-triazoleB-6     1-[2-(2,4-Dichlorophenyl)pentyl]-                        Penconazole   1H-1,2,4-triazoleB-7     Bis(4-fluorophenyl)(methyl)(1H-                        Flusilazole   1,2,4-triazol-1-ylmethyl)silaneB-8     2-(4-Chlorophenyl)-2-(1H-1,2,4-                        Myclobutanil   triazol-1-ylmethyl)hexanenitrileB-9     (2RS, 3RS)-2-(4-Chlorophenyl)-3-                        Cyproconazole   cyclopropyl-1-(1H-1,2,4-triazol-   1-yl)butan-2-ol B-10   (RS)-1-(4-Chlorophenyl)-4,4-                        Terbuconazole   dimethyl-3-(1H-1,2,4-triazol-   1-ylmethyl)pentan-3-ol B-11   (RS)-2-(2,4-Dichlorophenyl)-1-                        Hexaconazole   (1H-1,2,4-triazol-1-yl)hexan-   2-ol B-12   (2RS, 5RS)-5-(2,4-Dichloro-                        Furconazole-   phenyl)tetrahydro-5-(1H-1,2,4-                        cis   triazol-1-ylmethyl)-2-furyl   2,2,2-trifluoroethyl ether B-13   N-Propyl-N-[2-(2,4,6-trichloro-                        Prochloraz   phenoxy)ethyl]imidazole-1-   carboxamideQuinoxaline Compounds:C-1     6-Methyl-1,3-dithiolo[4,5-b]-                        Chinomethio-   quinoxalin-2-one     nateDithiocarbamate Compounds:D-1     Manganese ethylenebis(dithio-                        Maneb   carbamate) polymerD-2     Zinc ethylenebis(dithiocarbamate)                        Zineb   polymerD-3     Complex of zinc and manganese                        Mancozeb   ethylenebis(dithiocarbamate)   (Maneb)D-4     Dizinc bis(dimethyldithio)-                        Polycarbamate   carbamate) ethylenebis-   (dithiocarbamate)D-5     Zinc propylenebis(dithio-                        Propineb   carbamate) polymerOrganic Chlorine Compounds:E-1     4,5,6,7-Tetrachlorophthalide                        FthalideE-2     Tetrachloroisophthalonitrile                        Chlorothalo-                        nilE-3     Pentachloronitrobenzene                        QuintozeneE-4     2,2,2-Trichloro-1,1-bis(4-                        Dicofol   chlorophenyl)ethanolBenzimidazole Compounds:F-1     Methyl 1-(butylcarbamoyl)benz-                        Benomyl   imidazol-2-yl carbamateF-2     Dimethyl 4,4'-(o-phenylene)-bis-                        Thiophanate-   (3-thioallophanate)  methylF-3     Methyl benzimidazol-2-                        Carbendazim   ylcarbamatePyridinamine Compounds:G-1     3-Chloro-N-(3-chloro-2,6-dinitro-                        Fluazinam   4-α,α,α-trifluorotolyl)-5-tri-   fluoromethyl-2-pyridinamineCyanoacetamide Compounds:H-1     1-(2-Cyano-2-methoxyiminoacetyl)-                        Cymoxanil   3-ethylureaPhenylamide Compounds:I-1     Methyl N-(2-methoxyacetyl)-N-                        Metalaxyl   (2,6-xylyl)-DL-alaninateI-2     2-Methoxy-N-(2-oxo-1,3-oxa-                        Oxadixyl   zolidin-3-yl)acet-2',6'-xylidideI-3     ()-α-2-Chloro-N-(2,6-xylylacet-                        Ofurace   amide)-γ-butyrolactoneI-4     Methyl N-phenylacetyl-N-(2,6-                        Benalaxyl   xylyl)-DL-alaninateI-5     Methyl N-(2-furoyl)-N-(2,6-                        Furalaxyl   xylyl)-DL-alaninateI-6     ()-α-[N-(3-Chlorophenyl)cyclo-                        Cyprofuram   propane-carboxamide]-γ-butyro-   lactoneSulfenic Acid Compounds:J-1     N-Dichlorofluoromethylthio-N',N'-                        Dichlo-   dimethyl-N-phenylsulphamide                        fluanidCopper Compounds:K-1     Copper hydroxide     Copper                        HydroxideK-2     Copper-8-quinolinolate                        Oxine-copperIsoxazole Compounds:L-1     5-Methylisoxazol-3-ol                        Hydroxy-                        isoxazoleOrganophosphorus Compounds:M-1     Aluminum tris(ethyl phosphonate)                        Fosetyl-AlM-2     O-2,6-Dichloro-p-tolyl-                        Tolclofos-   O,O-dimethyl phosphorothioate                        methylM-3     (RS)-S-(RS)-Sec-butyl-O-ethyl-                        disclosed in   2-oxo-2-thiazolidinyl-                        U.S. Pat. No.   phosphonothioate     4,590,182M-4     O,S-Dimethyl acetylphosphor-                        Acephate   amidothioateM-5     2,2-Dichlorovinyl dimethyl                        Dichlorvos   phosphateM-6     O-2,4-Dichlorophenyl O-ethyl                        Prothiofos   S-propyl phosphorodithioateN-Halogenothioalkyl Compounds:N-1     N-(Trichloromethylthio)cyclohex-                        Captan   4-ene-1,2-dicarboximideN-2     N-(1,1,2,2-Tetrachloroethyl-                        Captafol   thio)cyclohex-4-ene-1,2-di-   carboximideN-3     N-(Trichloromethylthio)phthal-                        Folpet   imideDicarboximide Compounds:O-1     N-(3,5-Dichlorophenyl)-1,2-di-                        Procymidone   methylcyclopropane-1,2-di-   carboximideO-2     3-(3,5-Dichlorophenyl)-N-iso-                        Iprodione   propyl-2,4-dioxoimidazolidine-1-   carboxamideO-3     (RS)-3-(3,5-Dichlorophenyl)-5-                        Vinclozolin   methyl-5-vinyl-1,3-oxazolidine-   2,4-dioneBenzanilide Compounds:P-1     α,α,α-Trifluoro-3'-isopropoxy-                        Flutolanil   o-toluanilideP-2     3'-Isopropoxy-o-toluanilide                        MepronilBenzamide Compounds:Q-1     (RS)-4-Chloro-N-[cyano(ethoxy)-                        disclosed in   methyl]benzamide     U.S. Pat. No.                        4,447,446Q-2     2-(1,3-Dimethylpyrazol-4-yl-                        disclosed in   carbonylamino)-4-methyl-3-                        British   pentenenitrile       Patent                        2,190,375Q-3     α-(Nicotinylamino)-(3-fluoro-                        disclosed in   phenyl)acetonitrile  JP-A-63-                        135364______________________________________

(The term "JP-A" as used herein means a "published unexamined patent application".)

______________________________________Compound                     CommonNo.     Compound Name        Name______________________________________Piperazine Compounds:R-1     N,N'-[Piperazine-1,4-diylbis-                        Triforine   [(trichloromethyl)methylene]]-   diformamidePyridine Compounds:S-1     2',4'-Dichloro-2-(3-pyridyl)-                        Pyrifenox   acetophenone O-methyloximePyrimidine Compounds:T-1     ()-2,4'-Dichloro-α-(pyrimidin-                        Fenarimol   5-yl)benzhydryl alcoholPiperidine Compounds:U-1     (RS)-1-[3-(4-Tert-butylphenyl)-                        Fenpropidin   2-methylpropyl]piperidineMorpholine Compounds:V-1     ()-Cis-4-[3-(4-tert-butyl-                        Fenpropimorph   phenyl)-2-methylpropyl]-2,6-   dimethylmorpholineOrganotin Compounds:W-1     Triphenyltin hydroxide  Fentin                           hydroxideW-2     Triphenyltin acetate    Fentin                           acetateUrea Compounds:X-1     1-(4-Chlorobenzyl)-1-cyclo-                        Pencycuron   pentyl-3-phenylureCinnamic Acid Compounds:Y-1     (E,Z)4-[3-(4-Chlorophenyl)-3-                        Dimethomorph   (3,4-dimethoxyphenyl)acryloyl]   morpholineCarbamate Compounds:Za-1    1-Naphthyl methylcarbamate                        CarbarylZa-2    S-Methyl N-(methylcarbamoyloxy)-                        Methomyl   thioacetimidateZa-3    2-Ethylthiomethylphenyl                        Ethiofencarb   methylcarbamateZa-4    Ethyl N-benzyl-N-[[methyl-                        ORION    [[(Z)-1-methylthioethylidene]-                        (trade name)   aminooxycarbonyl]amino]thio]-   β-alaninatePyrethroid Compounds:Zb-1    (RS)-α-Cyano-3-phenoxybenzyl                        Cyhalothrin   (Z)-(1RS, 3RS)-(2-chloro-3,3,3-   trifluoropropenyl)-2,2-dimethyl-   cyclopropanecarboxylateZb-2    2,3,5,6-Tetrafluoro-4-methyl-                        Tefluthrin   benzyl (Z)-(1RS, 3RS)-3-(2-   chloro-3,3,3-trifluoroprop-1-   enyl)-2,2-dimethylcyclopropane-   carboxylateZb-3    2-(4-Ethoxyphenyl)-2-methyl-                        Ethofenprox   propyl-3-phenoxybenzyl etherZb-4    (RS)-α-Cyano-3-phenoxybenzyl                        Cypermethrin   (1RS, 3RS; 1RS, 3SR)-3-(2,2-   dichlorovinyl)-2,2-dimethylcyclo-   propanecarboxylateBenzoylurea Compounds:Zc-1    1-(4-Chlorophenyl)-3-(2,6-                        Diflubenzuron   difluorobenzoyl)ureaZc-2    1-(3,5-Dichloro-2,4-difluoro-                        Teflubenzuron   phenyl)-3-(2,6-difluorobenzoyl)-   ureaZc-3    1-[3,5-Dichloro-4-(3-chloro-5-                        Chlorfluaz-   trifluoromethyl-2-pyridyloxy)-                        uron   phenyl]-3-(2,6-difluorobenzoyl)-   ureaThiazolidine Compounds:Zd-1    (4RS, 5RS)-5-(4-Chlorophenyl)-                        Hexythiazox   N-cyclohexyl-4-methyl-2-oxo-   1,3-thiazolidine-3 carboxamideThiadiazine Compounds:Ze-1    2-Tert-butylimino-3-isopropyl-                        Buprofezin   5-phenyl-1,3,5-thiadiazinan-4-oneNereistoxin DerivativesZf-1    N,N-Dimethyl-1,2,3-trithian-                        Thiocyclam   5-ylamineZf-2    S,S'-2-Dimethylaminotri-                        Cartap   methylene bis(thiocarbamate)Pyridazinone Compounds:Zg-1    2-Tert-butyl-5-(4-tert-butyl-                        disclosed in   benzylthio)-4-chloropyridazin-                        European   3(2H)-one            Patent                        134,439Spores of Bacillus thuringiensis and crystalline toxinproduced thereby:    Name of PathogenZh-1    Bacillus thuringiensis                        THURI-   subsp, Kurstaki, HD-1                        CIDE  (trade                        name)______________________________________

The imidazole compounds represented by formula (I) can be prepared, for example, by the following reaction schemes. ##STR6## wherein Z represents a hydrogen atom, a chlorine atom, or a bromine atom; Y represents a chlorine atom, a fluorine atom, a bromine atom, or an iodine atom; Y' represents a chlorine atom, a bromine atom, or an iodine atom; and R1 is as defined above. ##STR7## wherein Y, R1, and R2 are as defined above.

Step 1 of process A and Process B are carried out, if desired, in the presence of a solvent and an acid acceptor.

The solvent which can be used includes aromatic hydrocarbons, e.g., benzene, toluene, xylene, chlorobenzene, etc.; cyclic or acyclic aliphatic hydrocarbons, e.g., chloroform, carbon tetrachloride, methylene chloride, dichloroethane, trichloroethane, n-hexane, cyclohexane, etc.; ethers, e.g., diethyl ether, dioxane, tetrahydrofuran, etc.; ketones, e.g., acetone, methyl ethyl ketone, methyl isobutyl ketone, etc.; nitriles, e.g., acetonitrile, propionitrile, etc.; and aprotic polar solvents, e.g., dimethylformamide, N-methylpyrrolidone, dimethyl sulfoxide, sulfolane, etc.

The acid acceptor which can be used includes inorganic bases such as alkali metal hydroxides, e.g., sodium hydroxide and potassium hydroxide, alkali metal or alkaline earth metal carbonates, e.g., anhydrous potassium carbonate and anhydrous calcium carbonate, alkali metal hydrides, e.g., sodium hydride, and alkali metals, e.g., metallic sodium; and organic basis, e.g., triethylamine.

The reactions of Step 1 of Process A and Process B can be effected in the presence of an appropriate catalyst, such as a phase transfer catalyst (e.g., quaternary ammonium salt derivatives).

The compound represented by formula (II), the starting compounds of Process B, can be prepared according to the following process or processes similar thereto. ##STR8## wherein R3 represents a hydrogen atom or a halogen atom; and R1 is as defined above.

The compound of formula (II) includes tautomers represented by the following formulae: ##STR9## wherein R1 and R2 are as defined above.

Accordingly, in cases where the compound of formula (I) is prepared by starting with the compound of formula (II), the compounds having formulae (I-a) and/or (I-b) can be obtained.

Thus, the reaction of introducing --SO2 N(CH3)2 group to the starting compound including tautomers yields either one of the two isomers or a mixture thereof. Whether a mixture of tautomers or either one of the tautomers is obtained depends on the starting compound, the reaction process of from the starting compound through the product, the reaction conditions, and the like. In the case where a mixture is obtained, the mixing ratio is also determined by these factors.

Synthesis Examples of the imidazole compounds of formula (I) are exemplified below.

SYNTHESIS EXAMPLE 1 Synthesis of 4-chloro-2-cyano-1-dimethyl-sulfamoyl-5-n-propylimidazole (Compound No. A-6b)

(1) 2-Formyl-1-diethoxymethylimidazole was obtained as an oily substance from 1-diethoxymethylimidazole in accordance with the method described in J. Org. Chem., Vol. 45, 4038-4040 (1980). The resulting compound was reacted with hydroxylamine hydrochloride-sodium acetate in water to obtain imidazole-2-aldoxime, which was then dehydrated with acetic anhydride to obtain 2-cyanoimidazole having a melting point of 176 C.

(2) Thirty grams of 2-cyanoimidazole as obtained in (1) above, 53.4 g of anhydrous potassium carbonate, and 600 ml of acetonitrile were mixed at room temperature, and the mixture was allowed to react at reflux for 2 hours. After cooling, 55.6 g of dimethylsulfamoyl chloride was added thereto, and the reaction at reflux was continued for an additional period of 2 hours.

After completion of the reaction, the reaction mixture was poured into water and extracted with methylene chloride. The extract was washed with water and dried over anhydrous sodium sulfate. The solvent was removed by distillation, and the residue was purified by silica gel column chromatography using methylene chloride as a developing solvent to obtain 28.0 g of 2-cyano-1-dimethylsulfamoylimidazole having a melting point of from 74 to 76 C.

(3) In a four-necked flask were charged in a nitrogen atmosphere 12.0 g of 2-cyano-1-dimethylsulfamoylimidazole as obtained in (2) above and 240 ml of anhydrous tetrahydrofuran, and 41.3 ml of a 1.6M n-butyl lithium-hexane solution (produced by Aldrich) was gradually added dropwise to the mixture while maintaining at a temperature of -75 C. or lower with dry ice-acetone. After the dropwise addition, the mixture was kept at that temperature for 15 minutes, and 30 ml of a tetrahydrofuran solution of 15.3 g of n-propyl iodide was added dropwise thereto at -70 C. or lower. After the dropwise addition, the reaction mixture was stirred overnight to gradually elevate the temperature to room temperature.

After completion of the reaction, the reaction mixture was poured into water and extracted with 500 ml of ethyl acetate. The ethyl acetate layer was washed with water and dried over anhydrous sodium sulfate. The ethyl acetate was removed by distillation, and the residue was purified by silica gel column chromatography using methylene chloride as a developing solvent and separated to give 4.8 g of 2-cyano-1-dimethylsulfamoyl-5-n-propylimidazole having a melting point of from 51 to 52 C.

(4) 4.8 g of 2-cyano-1-dimethylsulfamoyl-5-n-propylimidazole as obtained in (3) above, 40 ml of pyridine, and 11.4 g of pyridinium chloride were mixed, and the mixture was stirred at 90 C. for 4 hours.

After completion of the reaction, the pyridine was removed by distillation from the reaction mixture, and the residue was extracted with ethyl acetate. The extract was washed with water and then dried over anhydrous sodium sulfate. Thereafter, the ethyl acetate was removed by distillation, and the residue was purified by silica gel column chromatography (developing solvent: a mixture of ethyl acetate and n-hexane) and separated to give 2.46 g of 2-cyano-4(5)-n-propylimidazole having a melting point of from 52 to 54 C.

(5) 2.35 g of 2-cyano-4(5)-n-propylimidazole as obtained in (4) above, 80 ml of chloroform, and 2.6 g of N-chlorosuccinimide were mixed, and the mixture was reacted at the reflux temperature for 4 hours.

After completion of the reaction, 200 ml of water was added to the reaction mixture. The resulting organic layer was washed with water and then dried over anhydrous sodium sulfate. The chloroform was removed by distillation, and the residue was purified by silica gel column chromatography (developing solvent: a 1:1 mixture of ethyl acetate and n-hexane) and separated to give 2.2 g of 4(5)-chloro-2-cyano-5(4) n-propylimidazole having a melting point of from 107 to 109 C.

(6) 2.0 g of 4(5)-chloro-2-cyano-5(4)-n-propylimidazole as obtained in (5) above, 30 ml of acetonitrile, 1.95 g of anhydrous potassium carbonate, and 1.86 g of dimethylsulfamoyl chloride were mixed, and after gradually elevating the temperature, the mixture was reacted at the reflux temperature for 1 hour.

After completion of the reaction, the acetonitrile was removed by distillation from the reaction mixture. After pouring 100 ml of water into the residue, the resulting mixture was extracted with 50 ml of methylene chloride. The extract was washed with water and dried over anhydrous sodium sulfate. The methylene chloride was removed by distillation, and the residue was allowed to stand overnight at room temperature. The analysis of the residue revealed that one of the two isomers in the mixture decomposed and returned to the starting 4(5)-chloro-2-cyano-5(4)-n-propylimidazole. The residue containing the other isomer was purified by silica gel column chromatography (developing solvent: methylene chloride) and separated to give 1.1 g of 4-chloro-2-cyano-1-dimethylsulfamoyl-5-n-propylimidazole (Compound No. A-6b) having a melting point of from 64 to 66 C.

SYNTHESIS EXAMPLE 2 Synthesis of 4-chloro-2-cyano-1-dimethylsulfamoyl-5-phenylimidazole (Compound No. A-1b)

(1) In 100 ml of chloroform was dissolved 1.352 g of 2-cyano-4(5)-phenylimidazole, and 1.175 g of N-chlorosuccinimide was added to the solution. The mixture was reacted upon heating at the reflux temperature for 4 hours.

After completion of the reaction, the reaction mixture was poured into water and extracted with chloroform. After washing with water, the extracted layer was dried over anhydrous sodium sulfate. The solvent was distilled off under reduced pressure, and the residue was purified by silica gel column chromatography (developing solvent: methylene chloride) to give 1.28 g of 4(5)-chloro-2-cyano-5(4)-phenylimidazole having a melting point of from 149 to 151 C.

(2) In 6 ml of acetone was dissolved 0.43 g of 4(5)- chloro-2-cyano-5(4)-phenylimidazole as obtained in (1) above, and 0.29 g of anhydrous potassium carbonate and 0.36 g of dimethylsulfamoyl chloride were added to the solution. The mixture was reacted upon heating at the reflux temperature for 30 minutes.

After completion of the reaction, the reaction mixture was poured into water and extracted with ethyl acetate. After washing with water, the extracted layer was dried over anhydrous sodium sulfate. The solvent was distilled off under reduced pressure, and the residue was then purified by silica gel column chromatography (developing solvent: methylene chloride) to give 0.5 g of 4(5)-chloro-2-cyano-1-dimethylsulfamoyl-5(4)phenylimidazole having a melting point of from 106 to 109 C.

As a result of analysis by means of NMR spectra, the compound described above was found to be an isomeric mixture of 4-chloro-2-cyano-1-dimethylsulfamoyl-5-phenylimidazole and 5-chloro-2-cyano-1-dimethylsulfa- moyl-4-phenylimidazole in almost equal ratios.

(3) After allowing to stand for 24 hours at room temperature, 2.9 g of the mixture of these isomers as obtained in a manner similar to (2) above was purified by silica gel column chromatography (developing solvent: methylene chloride) to give 1.15 g of 4-chloro-2-cyano-1-dimethylsulfamoyl-5-phenylimidazole (Compound No. A-1b) having a melting point of from 109 to 112 C. Further, by purification of and isolation from this compound, 0.7 g of 4(5)-chloro-2-cyano-5(4)-phenylimidazole was also obtained.

SYNTHESIS EXAMPLE 3 Synthesis of 4-chloro-5-(3-chloropropyl)-2-cyano-1-dimethylsulfamoylimidazole (Compound No. A-12b)

(1) In a four-necked flask were charged in a nitrogen atmosphere 9.4 g of 2-cyano-4,5-dichloro-1-dimethylsulfamoylimidazole and 152 ml of anhydrous tetrahydrofuran, and 28.6 ml of a 1.6 M n-butyl lithiumhexane solution was slowly added thereto while maintaining at a temperature of -75 C. or lower by cooling with dry ice-acetone. After the dropwise addition, the mixture was kept at that temperature for 15 minutes. Then, 31 ml of a tetrahydrofuran solution of 14.3 g of 1-chloro-3-iodopropane was added dropwise to the mixture at -70 C. or lower, followed by stirring at room temperature overnight to gradually elevate the temperature to room temperature.

After completion of the reaction, the reaction mixture was poured into water and extracted with methylene chloride. The extract was washed with water and dried over anhydrous sodium sulfate. The methylene chloride was removed by distillation, and the residue was purified by silica gel column chromatography once using methylene chloride and then using a mixture of n-hexane and ethyl acetate as developing solvents to obtain 4.1 g of 4-chloro-5-(3-chloropropyl)-2-cyano-1-dimethylsulfamoylimidazole (Compound No. A-12b) having a melting point of from 102 to 105 C.

The biocidal compositions according to the present invention, comprising the imidazole compound of formula (I) in combination with other specific compound, are particularly useful as agricultural fungicides. Specifically, they exhibit excellent effects of controlling diseases of crop plants such as rice blast caused by Pyricularia oryzae, rice sheath blight caused by Rhizoctonia solani, cucumber anthracnose caused by Colletotrichum lagenarium, cucumber powdery mildew caused by Sphaerotheca fuliginea, cucumber downy mildew caused by Pseudoperonospora cubensis, tomato late blight caused by Phytophthora infestans, tomato early blight caused by Alternaria solani, citrus melanose caused by Diaporthe citri, citrus common green mold caused by Penicillium digitatum, pear scab caused by Venturia nashicola, apple alternaria blotch caused by Alternaria mali, grape downy mildew caused by Plasmopara viticola, gray mold caused by Botrytis cinerea, sclerotinia rot caused by Sclerotinia sclerotiorum, rust, etc.; and soil diseases caused by phytopathogenic fungi such as Fusarium, Pythium, Rhizoctonia, Verticillium, Plasmodiophora, etc. In particular, the biocidal compositions of the present invention exhibit excellent effects of controlling diseases such as potato or tomato late blight caused by Phytophthora infestans, cucumber downy mildew caused by Pseudoperonospora cubensis, grape downy mildew caused by Plasmopara viticola, tobacco blue mold caused by Peronospora tabacina; and various soil diseases caused by phycomycetes such as Plasmodiophora, Aphanomyces, Pythium, etc.

The biocidal compositions of the present invention have a prolonged residual effect so that they exhibit an excellent preventive effect, and also exhibit an excellent curative effect as well. It is therefore possible to control diseases by treatment after infection. In addition, since they possess a systemic activity, it is also possible to control diseases of the stem and leaf by soil treatment.

Further, the biocidal compositions of the present invention show an excellent controlling effect against agriculturally and horticulturally harmful insects such as planthoppers, diamondback moth (Plutella xylostella), green rice leafhopper (Nephotettix cincticeps), adzuki bean weevil (Callosobruchus chinensis), common cutworm (Spodoptera litura), green peach aphid (Myzus persicae), etc.; mites such as twospotted spider mite (Tetranychus urticae), carmine spider mite (Tetranychus cinnabarinus), citrus red mite (Panonychus citri), etc.; and nematodes such as southern root-knot nematode (Meloidogyne incognita), etc.

The compounds constituting the biocidal composition of the present invention can be formulated into a variety of forms, such as emulsifiable concentrates, dusts, wettable powders, aqueous solutions, granules, suspension concentrates, etc., together with various adjuvants, as in conventional agricultural preparations. The imidazole compound of formula (I) and the other specific compound may be mixed and formulated, or each of the compounds may be separately formulated and then mixed together. Upon use, the preparation may be used as such or as diluted with an appropriate diluent, e.g., water, to a predetermined concentration.

Examples of the adjuvants which can be used include carriers, emulsifying agents, suspending agents, dispersing agents, spreaders, penetrating agents, wetting agents, thickeners, stabilizers, etc. These adjuvants can be added appropriately according to necessity.

The carriers are classified into solid carriers and liquid carriers. The solid carriers include animal and vegetable powders, e.g., starch, sugar, cellulose powders, cyclodextrin, activated charcoal, soybean powders, wheat powders, chaff powders, wood powders, fish powders, powdery milk, etc., and mineral powders, e.g., talc, kaolin, bentonite, bentonite-alkylamine complexes, calcium carbonate, calcium sulfate, sodium bicarbonate, zeolite, diatomaceous earth, white carbon, clay, alumina, silica, sulfur powders, etc. The liquid carriers include water, animal and vegetable oils, e.g., soybean oil, cotton seed oil, etc., alcohols, e.g., ethyl alcohol, ethylene glycol, etc., ketones, e.g., acetone, methyl ethyl ketone, etc., ethers, e.g., dioxane, tetrahydrofuran, etc., aliphatic hydrocarbons, e.g., kerosene, lamp oil, liquid paraffin, etc., aromatic hydrocarbons, e.g., xylene, trimethylbenzene, tetramethylbenzene, cyclohexane, solvent naphtha, etc., halogenated hydrocarbons, e.g., chloroform, chlorobenzene, etc., acid amides, e.g., dimethylformamide, etc., esters, e.g., ethyl acetate, fatty acid glycerine esters, etc., nitriles,, e.g., acetonitrile, etc., sulfur-containing compounds, e.g., dimethyl sulfoxide, etc., N-methylpyrrolidone, and so on.

A suitable mixing ratio of the imidazole compound of formula (I) and other specific compound usually ranges from 1:300 to 300:1, preferably from 1:100 to 100:1, and more preferably from 1:50 to 5:1, by weight.

The concentration of the biocidal composition of the present invention is hard to specify as it varies depending on the crop to which the composition is applied, the method of application, the preparation form, the dose to be applied, and the like. Generally speaking, the concentrations of the imidazole compound of formula (I) and the specific compound to be combined are from 1 to 1,000 ppm and from 1 to 5,000 ppm, respectively, in the case of foliar treatment, and those in the case of soil treatment are from 10 to 10,000 g/ha and from 10 to 50,000 g/ha, respectively.

Examples of testing of the biocidal compositions according to the present invention as agricultural and horticultural fungicides are hereinafter given for illustrative purposes only but not for limitation.

TEST EXAMPLE 1 Test on preventive effect against tomato late blight

Tomato (cultivars: Ponderosa) was cultivated in a polyethylene pot having a diameter of 7.5 cm. When - tomato reached the four-leaf stage, 10 ml of a solution obtained from each of test compounds adjusted to a predetermined concentration was sprayed over tomato using a spray gun. After keeping the pots in a constant temperature chamber of 22 to 24 C. over one day and one night, a zoosporangium suspension of fungi of late blight (Phytophthora infestans) was inoculated by spraying. Five days after the inoculation, an area of lesion on the leaves was investigated, and an index of control was determined according to the following standard. The results obtained are shown in Tables 2-1 through 2-6.

The controlling effect was determined by visually observing a degree of disease of a test plant and expressed by the following 5 grades of the index of control.

______________________________________[Index of Control]         [Degree of Disease]______________________________________5             No lesion is noted at all.4             Area of lesions is less than 10% as         compared to the non-treated plot.3             Area of lesions is less than 40% as         compared to the non-treated plot.2             Area of lesions is less than 70% as         compared to the non-treated plot.1             Area of lesions is 70% or more as         compared to the non-treated plot.______________________________________

              TABLE 2-1______________________________________         ConcentrationCompound No.  (ppm)       Index of Control______________________________________A-6b          0.5         3         0.125       1B-3           31          2         8           2A-6b + B-3    0.5 + 31    4         0.5 + 8     4         0.125 + 31  3         0.125 + 8   4C-1           31          1         8           1A-6b + C-1    0.5 + 31    5         0.5 + 8     5         0.125 + 31  2         0.125 + 8   2______________________________________

              TABLE 2-2______________________________________         ConcentrationCompound No.  (ppm)       Index of Control______________________________________A-6b          0.5         5         0.125       3D-3           31          3         8           1A-6b + D-3    0.5 + 31    5         0.5 + 8     4         0.125 + 31  5         0.125 + 8   3E-2           31          2         8           1A-6b + E-2    0.5 + 31    5         0.5 + 8     5         0.125 + 31  5         0.125 + 8   3______________________________________

              TABLE 2-3______________________________________         ConcentrationCompound No.  (ppm)       Index of Control______________________________________A-1b          8           5         2           1         0.5         1F-1           31          2         8           1A-1b + F-1    8 + 31      5         8 + 8       5         2 + 31      5         2 + 8       3         0.5 + 31    1         0.5 + 8     1______________________________________

              TABLE 2-4______________________________________         ConcentrationCompound No.  (ppm)       Index of Control______________________________________A-1b          8           5         2           3         0.5         2G-1           8           3         2           1A-1b + G-1    8 + 8       5         8 + 2       5         2 + 8       5         2 + 2       4         0.5 + 8     5         0.5 + 2     3______________________________________

              TABLE 2-5______________________________________         ConcentrationCompound No.  (ppm)       Index of Control______________________________________A-1b          0.5         4         0.125       1D-3           31          1         8           1A-1b + D-3    0.5 + 31    5         0.5 + 8     5         0.125 + 31  4         0.125 + 8   4______________________________________

              TABLE 2-6______________________________________         ConcentrationCompound No.  (ppm)       Index of Control______________________________________A-1b          0.5         4         0.125       3H-1           8           3         2           3A-1b + H-1    0.5 + 8     5         0.5 + 2     5         0.125 + 8   3         0.125 + 2   4______________________________________
TEST EXAMPLE 2 Test on preventive effect against tomato late blight

A test similar to Test Example 1 was carried out. The degree of disease has visually observed to determine the index of control according to the following standard for evaluation. The results obtained are shown in Tables 3-1 through 3-3.

______________________________________Standard for Evaluation:[Index of Control]         [Degree of Disease]______________________________________7             No lesion is observed at all.6             Area or length of lesions is less         than 5% of that of the non-treated         plot.5             Area or length of lesions is from 5         to less than 10% of that of the non-         treated plot.4             Area or length of lesions is from 10         to less than 25% of that of the non-         treated plot.3             Area or length of lesions is from 25         to less than 40% of that of the non-         treated plot.2             Area or length of lesions is from 40         to less than 70% of that of the non-         treated plot.1             Area or length of lesions is 70% or         more of that of the non-treated         plot.______________________________________

              TABLE 3-1______________________________________         ConcentrationCompound No.  (ppm)       Index of Control______________________________________A-1b          0.125       4A-12b         0.125       2I-1           2           2         0.5         1A-1b + I-1    0.125 + 2   5         0.125 + 0.5 7A-12b + I-1   0.125 + 2   7         0.125 + 0.5 6______________________________________

              TABLE 3-2______________________________________        ConcentrationCompound No. (ppm)       Index of Control______________________________________A-1b         0.5         4I-2          31          5H-1          31          4Q-1           8          1A-1b + I-2   0.5 + 31    7A-1b + H-1   0.5 + 31    7A-1b + Q-1   0.5 + 8     7______________________________________

              TABLE 3-3______________________________________        ConcentrationCompound No. (ppm)       Index of Control______________________________________A-12b        0.5         4K-1          500         2I-2          8           3        2           1A-12b + K-1   0.5 + 500  7A-12b + I-2  0.5 + 8     7        0.5 + 2     7______________________________________
TEST EXAMPLE 3 Test of curative effect on tomato late blight

Tomato (cultivars: Ponderosa) was cultivated in a polyethylene pot having a diameter of 7.5 cm. When tomato reached the four-leaf stage, a zoosporangium suspension of fungi of late blight (Phytophthora infestans) was inoculated by spraying. Six hours later, 10 ml of a solution of each of test compounds at a predetermined concentration has sprayed onto the tomato plant using a spray gun. After keeping the pots in a constant temperature chamber of 22 to 24 C. for 5 days, an area of lesions was examined to obtain the index of control according to the standard of Test Example 2. The results obtained are shown in Tables 4-1 through 4-3.

              TABLE 4-1______________________________________        ConcentrationCompound No. (ppm)       Index of Control______________________________________A-1b         500         4        125         4I-1           8          3         2          1A-1b + I-1   500 + 8     7        500 + 2     7        125 + 8     7        125 + 2     5______________________________________

              TABLE 4-2______________________________________        ConcentrationCompound No. (ppm)       Index of Control______________________________________A-1b         500         3        125         1I-2           31         4H-1           8          3Q-1           8          4A-1b + I-2    500 + 31   6         125 + 31   6A-1b + H-1   500 + 8     5        125 + 8     6A-1b + Q-1   500 + 8     6______________________________________

              TABLE 4-3______________________________________        ConcentrationCompound No. (ppm)       Index of Control______________________________________A-12b         8          2         2          1I-2          31          2H-1          31          5         8          1Q-1          31          2A-12b + I-2  8 + 31      6        2 + 31      5A-12b + H-1  8 + 31      7        8 + 8       4A-12b + Q-1  8 + 31      6        2 + 31      6______________________________________
TEST EXAMPLE 4 Test of curative effect on cucumber downy mildew

Cucumber (cultivars: Suyo) was cultivated in a polyethylene pot having a diameter of 7.5 cm. When cucumber reached the two-leaf stage, a spore suspension of fungi of downy mildew (Pseudoperonospora cubensis) was inoculated by spraying. Twenty-four hours after the inoculation, 10 ml of a solution of each of test compounds adjusted to a predetermined concentration was sprayed over cucumber using a spray gun. After keeping the pots in a constant temperature chamber of 22 to 24 C. for 6 days, an area of lesion on the first leaf was visually observed to determine the index of control according to the standard of Test Example 2. The results obtained are shown in Tables 5-1 through 5-3.

              TABLE 5-1______________________________________        ConcentrationCompound No. (ppm)       Index of Control______________________________________A-1b         0.5         3        0.125       1A-12b        0.5         3        0.125       1I-1          8           3        2           1A-1b + I-1    0.5 + 8    6         0.5 + 2    4        0.125 + 8   4        0.125 + 2   1A-12b + I-1   0.5 + 8    5         0.5 + 2    4        0.125 + 8   4        0.125 + 2   1______________________________________

              TABLE 5-2______________________________________        ConcentrationCompound No. (ppm)       Index of Control______________________________________A-1b         0.5         1        0.125       1M-1          125         1Q-1          31          5        8           2A-1b + M-1    0.5 + 125  5        0.125 + 125 3A-1b + Q-1    0.5 + 31   7        0.5 + 8     4______________________________________

              TABLE 5-3______________________________________        ConcentrationCompound No. (ppm)       Index of Control______________________________________A-12b          0.5       3M-1          500         1        125         1I-2          8           2        2           1H-1          8           3        2           1Q-1          31          3        8           2A-12b + M-1   0.5 + 500  6         0.5 + 125  6A-12b + I-2  0.5 + 8     5        0.5 + 2     5A-12b + H-1  0.5 + 8     6        0.5 + 2     6A-12b + Q-1   0.5 + 31   6        0.5 + 8     6______________________________________
TEST EXAMPLE 5 Test on preventive effect against cucumber gray mold

Cucumber (cultivars: Suyo) was cultivated in a polyethylene pot having a diameter of 7.5 cm. When cucumber reached the two-leaf stage, 10 ml of a solution obtained from each of test compounds adjusted to a predetermined concentration has sprayed over cucumber using a spray gun. After keeping the pots in a constant temperature chamber of 22 to 24 C. over one day and one night, a mycelial disc having a diameter of 5 mm of fungi of gray mold (Botrytis cinerea) was inoculated on the first leaf. Three days after the inoculation, a length of lesion was investigated, and an index of control was determined according to the standard of Test Example 2. The results shown in Table 6 were obtained.

              TABLE 6______________________________________        ConcentrationCompound No. (ppm)       Index of Control______________________________________A-1b         500         1        125         1J-1           8          2         2          1O-1           31         3A-1b + J-1   500 + 8     6        500 + 2     4A-1b + O-1   500 + 31    5        125 + 31    5______________________________________
TEST EXAMPLE 6 Test on preventive effect against rice sheath blight

Rice plant (cultivars: Chukyo Asahi) was cultivated in a polyethylene pot having a diameter of 7.5 cm. When rice plant reached the five-leaf stage, 20 ml of a solution obtained from each of test compounds adjusted to a predetermined concentration was sprayed over rice plant using a spray gun. After keeping the pots in a constant temperature chamber of 22 to 24 C. over one day and one night, rice straw in which fungi of sheath blight (Rhizoctonia solani) had been previously incubated was set between leaf sheath portions to inoculate. After keeping the pots in an inoculation room having a temperature of 28 C. and humidity of 100% for 5 days, a length of lesion was investigated, and an index of control was determined according to the standard of Test Example 2. The results shown in Table 7 were obtained.

              TABLE 7______________________________________        ConcentrationCompound No. (ppm)       Index of Control______________________________________A-1b         500         1        125         1A-12b        500         1        125         1P-1           31         4A-1b + P-1   500 + 31    7        125 + 31    7A-12b + P-1  500 + 31    7        125 + 31    7______________________________________
TEST EXAMPLE 7 Antimicrobial test (phytopathogenic fungi)

Mycelial disc (agar punching) of preincubated Pythium aphanidermatum was transplanted on potato-dextrose agar medium (PDA medium) containing 100 ppm of streptomycin and a predetermined concentration of each of test compounds. After incubation at 22 C. for 48 hours, a diameter of mycellium was measured. Inhibition of hyphal growth (%) was determined by the following equation. The results shown in Table 8 were obtained. ##EQU1##

              TABLE 8______________________________________                     Inhibition of         Concentration                     Hyphal GrowthCompound No.  (ppm)       (%)______________________________________A-1b          1           91         0.1         85A-12b         1           85         0.1         88L-1           100         54A-1b + L-1    1 + 100     100         0.1 + 100   100A-12b + L-1   1 + 100     100         0.1 + 100   100______________________________________

Formulation Examples of the biocidal composition according to the present invention are described below, but the present invention is not deemed to be limited thereto.

FORMULATION EXAMPLE 1

______________________________________Compound No. A-1b     5 parts by weightCompound No. D-3     45 parts by weightKaolin               40 parts by weightCalcium lignin sulfonate                 7 parts by weightDialkylsulfosuccinate                 3 parts by weight______________________________________

The above components are uniformly mixed to prepare a wettable powder.

FORMULATION EXAMPLE 2

A wettable powder can be prepared in the same manner as in Formulation Example 1, except for replacing Compound No. A-1b with 25 parts by weight of Compound No. A-12b and replacing Compound No. D-3 with 25 parts by weight of Compound No. I-1.

FORMULATION EXAMPLE 3

A wettable powder can be prepared in the same manner as in Formulation Example 1, except for replacing Compound No. D-3 with Compound No. K-1.

FORMULATION EXAMPLE 4

______________________________________Compound No. A-1b      5 parts by weightCompound No. G-1      15 parts by weightCalcium carbonate     20 parts by weightKaolin                52 parts by weightCalcium lignin sulfonate                  4 parts by weightPolyoxyethylene alkylaryl ether                  4 parts by weight______________________________________

The above components are uniformly mixed to prepare a wettable powder.

FORMULATION EXAMPLE 5

A wettable powder can be prepared in the same manner as in Formulation Example 4, except for replacing Compound No. G-1 with Compound No. F-1.

FORMULATION EXAMPLE 6

A wettable powder can be prepared in the same manner as in Formulation Example 4, except for replacing Compound No. G-1 with Compound No. O1.

FORMULATION EXAMPLE 7

______________________________________Compound No. A-6b     5 parts by weightCompound No. B-3      5 parts by weightDiatomaceous earth   84 parts by weightDialkylsulfosuccinate                 2 parts by weightPolyoxyethylene alkylphenyl                 4 parts by weightether sulfate______________________________________

The above components are uniformly mixed to prepare a wettable powder.

FORMULATION EXAMPLE 8

A wettable powder can be prepared in the same manner as in Formulation Example 7, except for replacing Compound No. B-3 with Compound No. M-1.

FORMULATION EXAMPLE 9

______________________________________Kaolin                78 parts by weightSodium β-naphthalenesulfonate-                  2 parts by weightformaldehyde condensatePolyoxyethylene alkylaryl                  5 parts by weightsulfateHydrated amorphous silicon                 15 parts by weightdioxide______________________________________

A mixture consisting of the above components is mixed with Compound No. A-1b and Compound No. I-1 at a weight mixing ratio of 8:1:1 to prepare a wettable powder.

FORMULATION EXAMPLE 10

A wettable powder can be prepared in the same manner as in Formulation Example 9, except for replacing Compound No. I-1 with Compound No. I-7.

FORMULATION EXAMPLE 11

______________________________________Compound No. A-12b  0.25   parts by weightCompound No. I-1    0.25   parts by weightCalcium carbonate   99.0   parts by weightLower alcohol phosphate               0.5    parts by weight______________________________________

The above components are uniformly mixed to prepare a dust.

FORMULATION EXAMPLE 12

______________________________________Compound No. A-6b    2.5   parts by weightCompound No. H-1     2.5   parts by weightXylene               75    parts by weightPolyoxyethylene alkylaryl ether                20    parts by weight______________________________________

The above components are mixed and dissolved to prepare an emulsifiable concentrate.

FORMULATION EXAMPLE 13

______________________________________Compound No. A-1b   0.5   parts by weightCompound No. I-1    0.5   parts by weightBentonite           20    parts by weightKaolin              74    parts by weightSodium lignin sulfonate               5     parts by weight______________________________________

To the above components is added an adequate amount of water for granulation, and the mixture is mixed and granulated to prepare granules.

FORMULATION EXAMPLE 14

______________________________________Compound No. A-1b   2.5    parts by weightCompound No. D-3    22.5   parts by weightKerosene            63     parts by weightA mixture of polyoxyethylene               12     parts by weightphenylphenol derivative andpolyoxyethylene sorbitanalkylate______________________________________

The above components are mixed and finely pulverized to prepare a suspension concentrate.

FORMULATION EXAMPLE 15

A suspension concentrate can be prepared in the same manner as in Formulation Example 14, except for replacing Compound No. D-3 with Compound No. E-2.

While the invention has been described in detail and with reference to specific embodiments thereof, it will be apparent to one skilled in the art that various changes and modifications can be made therein without departing from the spirit and scope thereof.

Referenced by
Citing PatentFiling datePublication dateApplicantTitle
US5248675 *Jun 30, 1992Sep 28, 1993Tanabe Seiyaku Co., Ltd.Viricides for HIV
US5250520 *Mar 13, 1991Oct 5, 1993Tanabe Seiyaku Co., Ltd.Antiretrovirus activity
US5506216 *Apr 22, 1994Apr 9, 1996Boehringer Mannheim GmbhCyclodextrin-biocide complex
US5656281 *Jan 18, 1995Aug 12, 1997Rhone-Poulenc AgrochimieWater-dispersible granules of phosphite fungicidal products
US5891918 *Jun 18, 1997Apr 6, 1999Rohm And Haas CompanyMethod for controlling resistant fungi
Classifications
U.S. Classification514/92, 514/493, 514/476, 514/519, 514/531
International ClassificationA01N57/12, A01N53/00, A01N43/50, A01N47/14, A01N55/00, A01N59/20, A01N47/38, A01N47/34, C07D233/90
Cooperative ClassificationA01N43/50, C07D233/90
European ClassificationA01N43/50, C07D233/90
Legal Events
DateCodeEventDescription
Mar 13, 1989ASAssignment
Owner name: ISHIHARA SANGYO KAISHA, LTD.,, JAPAN
Effective date: 19890223
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST.;ASSIGNORS:NASU, RIKUO;KOMYOJI, TERUMASA;NAKAJIMA, TOSHIO;AND OTHERS;REEL/FRAME:005054/0133